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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ADAM11 Gene

protein-coding   GIFtS: 54
GCID: GC17P042847

ADAM metallopeptidase domain 11

(Previous name: a disintegrin and metalloproteinase domain 11 )
(Previous symbol: MDC)
 Explore 7 diseases affiliated with
ADAM11 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ADAM11    

Aliases
for ADAM11 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
ADAM Metallopeptidase Domain 111 2
MDC1 2 3 5
ADAM 112 3
A Disintegrin And Metalloproteinase Domain 111
Disintegrin And Metalloproteinase Domain-Containing Protein 112
Metalloproteinase-Like, Disintegrin-Like, And Cysteine-Rich Protein3

External Ids:    HGNC: 1891   Entrez Gene: 41852   Ensembl: ENSG000000736707   OMIM: 1551205   UniProtKB: O750783   

Export aliases for ADAM11 gene to outside databases

Previous GC identifers: GC17P042355 GC17P045013 GC17P043313 GC17P043286 GC17P040192 GC17P038601


Summaries
for ADAM11 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ADAM11:
This gene encodes a member of the ADAM (a disintegrin and metalloprotease) protein family. Members of this family are
membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of
biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development,
and neurogenesis. This gene represents a candidate tumor supressor gene for human breast cancer based on its location
within a minimal region of chromosome 17q21 previously defined by tumor deletion mapping. (provided by RefSeq, Jul
2008)

UniProtKB/Swiss-Prot: ADA11_HUMAN, O75078
Function: Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein

Gene Wiki entry for ADAM11


Genomic Views
for ADAM11 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ADAM11 gene promoter:
         Spz1   Pax-2   Pax-2a   AP-2gamma   GATA-1   PPAR-gamma1   AP-2beta   PPAR-gamma2   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ADAM11 promoter sequence
   Search SABiosciences Chromatin IP Primers for ADAM11

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADAM11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.3   Ensembl cytogenetic band:  17q21.31   HGNC cytogenetic band: 17q21.3

ADAM11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADAM11 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P042847:  view genomic region     (about GC identifiers)

Start:
 42,836,399 bp from pter      End:
 42,859,214 bp from pter
Size:
 22,816 bases      Orientation:
 plus strand

Proteins
for ADAM11 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ADA11_HUMAN, O75078 (See protein sequence)
Recommended Name: Disintegrin and metalloproteinase domain-containing protein 11 precursor  
Size: 769 amino acids; 83418 Da
Subunit: Can bind to LGI1 and LGI4 (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: Q14808 Q14809 Q14810
Alternative splicing: 2 isoforms:  O75078-1   O75078-2   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for ADAM11: NX_O75078

Post-translational modifications:

  • The precursor is cleaved by a furin endopeptidase (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O75078

    • ADAM11 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002381.2  
    ENSEMBL proteins: 
     ENSP00000200557   ENSP00000347856   ENSP00000443773   ENSP00000465537  

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    Browse Sino Biological Recombinant Proteins
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    Uscn Proteins for ADAM11

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS9693107
    GO:0016021integral to membrane IEA--
    GO:0031012colocalizes with extracellular matrix ISS--


    ADAM11 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for ADAM11 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ADAM11 for domains           About GeneDecksing

    5/8 InterPro domains/families (see all 8):
     IPR018358 Disintegrin_CS
     IPR024079 MetalloPept_cat_dom
     IPR001762 Blood-coag_inhib_Disintegrin
     IPR006586 ADAM_Cys-rich
     IPR000742 EG-like_dom

    Graphical View of Domain Structure for InterPro Entry O75078

    ProtoNet protein and cluster: O75078

    3 Blocks protein families:
    IPB001762 Disintegrin
    IPB002870 Metalloendopeptidase M12B
    IPB006586 ADAM


    UniProtKB/Swiss-Prot: ADA11_HUMAN, O75078
    Domain: A conserved motif [AVN[ED]CD] within the disintegrin-like domain could be involved in the binding to the
    integrin receptor
    Similarity: Contains 1 disintegrin domain
    Similarity: Contains 1 EGF-like domain
    Similarity: Contains 1 peptidase M12B domain


    Function
    for ADAM11 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ADA11_HUMAN, O75078
    Function: Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein

         Genatlas biochemistry entry for ADAM11:
    a disintegrin and metalloprotease (inactive) domain 11,membrane anchored cell surface adhesion protein with two
    isoforms MDC-769,MDC-524,highly expressed in the brain,also expressed in somatic tissues

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ADAM11
    8/39 QIAGEN miScript miRNA Assays for microRNAs that regulate ADAM11 (see all 39):
    hsa-miR-219-1-3p hsa-miR-132* hsa-miR-3607-3p hsa-miR-1321 hsa-miR-513a-5p hsa-let-7a-2* hsa-miR-30d hsa-miR-488
    SwitchGear 3'UTR luciferase reporter plasmid: ADAM11 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ADAM11 (see all 7)
    OriGene shRNA RFP: ADAM11
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    Gene Editing
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    Clone
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    Search LifeMap BioReagents cell lines for ADAM11

    In Situ Assay
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity IEA--
    GO:0005178integrin binding TAS9693107
    GO:0008237metallopeptidase activity TAS9693107
    GO:0008270zinc ion binding IEA--


    ADAM11 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Adam11tm1Sag for ADAM11
         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Adam11):
     behavior/neurological 

    ADAM11 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for ADAM11 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ADAM11

    2 Interacting proteins for ADAM11 (O750782, 3) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STC2O760612, 3MINT-63200 I2D: score=5 
    YWHABP319463I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IEA--
    GO:0007229integrin-mediated signaling pathway TAS8252040


    ADAM11 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ADAM11 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ADAM11 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ADAM11
    1 Novoseek chemical compound relationship for ADAM11 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mdc-2 91.5 3 10433968 (2)

    Search CenterWatch for drugs/clinical trials and news about ADAM11 / ADA11 

    Transcripts
    for ADAM11 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ADAM11 gene: 
    NM_002390.4  

    Unigene Cluster for ADAM11:

    ADAM metallopeptidase domain 11
    Hs.6088  [show with all ESTs]
    Unigene Representative Sequence: NM_002390
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000200557(uc002ihh.3 uc010wjd.2 uc002ihi.3) ENST00000355638
    ENST00000535346 ENST00000587773 ENST00000588363

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ADAM11
    8/39 QIAGEN miScript miRNA Assays for microRNAs that regulate ADAM11 (see all 39):
    hsa-miR-219-1-3p hsa-miR-132* hsa-miR-3607-3p hsa-miR-1321 hsa-miR-513a-5p hsa-let-7a-2* hsa-miR-30d hsa-miR-488
    SwitchGear 3'UTR luciferase reporter plasmid: ADAM11 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ADAM11 (see all 7)
    OriGene shRNA RFP: ADAM11
    OriGene siRNA: ADAM11
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADAM11
    Clone
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    GenScript: all cDNA clones in your preferred vector: ADAM11 (NM_002390)
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADAM11
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADAM11

    Additional cDNA sequence: 

    AB009675.1 AK296512.1 BC144550.1 D17390.1 

    3 DOTS entries:

    DT.91680801  DT.111546  DT.92326603 

    24/45 AceView cDNA sequences (see all 45):

    BX281439 BM720462 BU739874 BM720056 AA339669 BU740388 AI873177 BM557705 
    BU187486 R85092 BM472328 CD630834 T15471 CD630840 NM_002390 AB009675 
    BM727635 CD630844 CD630831 BM681070 AJ712115 BI755843 CD630835 NM_021612 

    GeneLoc Exon Structure


    Expression
    for ADAM11 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ADAM11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGACTTCCTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ADAM11 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeRetinaEye
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ADAM11 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ADAM11

    SOURCE GeneReport for Unigene cluster: Hs.6088

    UniProtKB/Swiss-Prot: ADA11_HUMAN, O75078
    Tissue specificity: Expressed predominantly in brain. Slightly detected or not at all in other tissues

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    In Situ
    Assay Products:     
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    Orthologs
    for ADAM11 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for ADAM11 gene from 5/21 species (see all 21)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves ADAM111 ADAM metallopeptidase domain 11 75.89(n)
    77.4(a)    		   428282  XM_425842.3  XP_425842.3 
    lizard
    (Anolis carolinensis)    		 Reptilia ADAM116
    		 --
    		 77(a)
    		 1 ↔ 1
    		 6(63594796-63661501)
    African clawed frog
    (Xenopus laevis)    		 Amphibia MDC11a2 metalloprotease/disintegrin xMDC11.1 74.4(n)    AF032384.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii adam111 a disintegrin and metalloproteinase domain 11 62.75(n)
    66.01(a)    		   567145  XM_690437.4  XP_695529.4 
    fruit fly
    (Drosophila melanogaster)    		 Insecta mmd1 , 3 metalloendopeptidase3
    mind-meld1    		 33(a)3
    48.51(n)1
    36.91(a)1    		   325611  NM_078634.51  NP_523358.51 


    ENSEMBL Gene Tree for ADAM11 (if available)
    TreeFam Gene Tree for ADAM11 (if available) 

    Paralogs
    for ADAM11 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ADAM11 gene
    ADAM72  ADAM192  ADAM122  ADAM232  ADAM332  ADAM302  ADAM222  ADAM282  
    ADAM292  ADAM202  ADAM92  ADAM212  ADAM152  ADAM82  
    10 SIMAP similar genes for ADAM11 using alignment to 4 protein entries:     ADA11_HUMAN (see all proteins):
    ADAM22    ADAM23    ADAM32    ADAM28    ADAM12    ADAM9
    ADAM19    ADAM15    ADAM7    ADAM33

    ADAM11 for paralogs           About GeneDecksing



    Genomic Variants
    for ADAM11 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/386 NCBI SNPs in ADAM11 are shown (see all 386)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1176668751,2
    		F,--42834581(+) GGAGGA/GCCCAG 1 -- us2k11Minor allele frequency- G:0.07EA 120
    rs1912747681,2
    		--42834600(+) AGCCCC/TGGGCT 1 -- us2k10--------
    rs765425621,2
    		--42834645(+) TGGGGG/TGCACT 1 -- us2k11Minor allele frequency- T:0.01WA 118
    rs1467990231,2
    		--42834753(+) CAGATA/GTACCA 1 -- us2k10--------
    rs1405182831,2
    		--42835008(+) CCTACA/GTCTTG 1 -- us2k10--------
    rs1823397441,2
    		--42835042(+) AGAGCA/GAAGGA 1 -- us2k10--------
    rs1456122581,2
    		--42835128(+) CCTACA/GTTGAT 1 -- us2k10--------
    rs348393541,2
    		C,F,H,--42835129(+) CTACAT/CTGATG 1 -- us2k115Minor allele frequency- C:0.14NS EA WA NA 2336
    rs1877101131,2
    		--42835188(+) AGAGCA/GGGGGG 1 -- us2k10--------
    rs590102021,2
    		C,F,--42835254(+) CTTGCA/GGAAGC 1 -- us2k110Minor allele frequency- G:0.48NA WA CSA EA 371

    HapMap Linkage Disequilibrium report for ADAM11 (42836399 - 42859214 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for ADAM11
         2 CNVs: 88486 5009

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    DNA2.0 Custom Variant and Variant Library Synthesis for ADAM11

    Disorders / Diseases
    for ADAM11 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ADAM11 for disorders           About GeneDecksing

    OMIM gene information: 155120    OMIM disorders: --

    7 diseases for ADAM11:    About MalaCards
    breast cancer    pancreatic cancer    prostate cancer    pancreatitis
    prostatitis    neuronitis    alcoholism

    2 Novoseek disease relationships for ADAM11 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 0 1 7956356 (1)
    tumors 0 3 7956356 (1), 11102971 (1)

    Genetic Association Database (GAD): ADAM11
    Human Genome Epidemiology (HuGE) Navigator: ADAM11 (1 document)

    Export disorders for ADAM11 gene to outside databases

    Publications
    for ADAM11 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ADAM11 gene, integrated from 9 sources (see all 25):
    (articles sorted by number of sources associating them with ADAM11)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel metalloprotease/disintegrin-like gene at 17q21.3 is somatically rearranged in two primary breast cancers. (PubMed id 8252040)1, 2, 3, 9 Emi M.... Nakamura Y. (1993)
    2. Human metalloprotease/disintegrin-like (MDC) gene: exon-intron organization and alternative splicing. (PubMed id 7956356)1, 2, 9 Katagiri T.... Nakamura Y. (1995)
    3. Metalloproteinase-like, disintegrin-like, cysteine-rich proteins MDC2 and MDC3: novel human cellular disintegrins highly expressed in the brain. (PubMed id 9693107)1, 2, 9 Sagane K.... Tanaka I. (1998)
    4. An unappreciated role for RNA surveillance. (PubMed id 14759258)1, 2 Hillman R.T.... Brenner S.E. (2004)
    5. ADH2 and alcohol-related phenotypes in Ashkenazic Jewish American college students. (PubMed id 11545539)1, 4 Shea S.H....Li T.K. (2001)
    6. Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. (PubMed id 18772397)2 Jones S.... Kinzler K.W. (2008)
    7. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
    8. Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes. (PubMed id 15203218)1 Fu G.K....Stuve L.L. (2004)
    9. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    External Searches for ADAM11 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing ADAM11 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4185 HGNC: 189 AceView: ADAM11 Ensembl:ENSG00000073670 euGenes: HUgn4185
    ECgene: ADAM11 H-InvDB: ADAM11

    Other Databases showing ADAM11 gene

    (According to HUGE)
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    Specialized Databases showing ADAM11 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ADAM11 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ADAM11 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for ADAM11 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ADAM11 gene:
    Search GeneIP for patents involving ADAM11

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