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ADAM11 Gene

protein-coding   GIFtS: 57
GCID: GC17P042847

ADAM Metallopeptidase Domain 11

(Previous name: a disintegrin and metalloproteinase domain 11)
(Previous symbol: MDC)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ADAM Metallopeptidase Domain 111 2     disintegrin-like1
MDC1 2 3 5     metalloproteinase-like1
ADAM 112 3     Disintegrin And Metalloproteinase Domain-Containing Protein 112
A Disintegrin And Metalloproteinase Domain 111     Metalloproteinase-Like, Disintegrin-Like, And Cysteine-Rich Protein3
Cysteine-Rich Protein1     

External Ids:    HGNC: 1891   Entrez Gene: 41852   Ensembl: ENSG000000736707   OMIM: 1551205   UniProtKB: O750783   

Export aliases for ADAM11 gene to outside databases

Previous GC identifers: GC17P042355 GC17P045013 GC17P043313 GC17P043286 GC17P040192 GC17P038601


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ADAM11 Gene:
This gene encodes a member of the ADAM (a disintegrin and metalloprotease) protein family. Members of this family
are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a
variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle
development, and neurogenesis. This gene represents a candidate tumor supressor gene for human breast cancer
based on its location within a minimal region of chromosome 17q21 previously defined by tumor deletion mapping.
(provided by RefSeq, Jul 2008)

GeneCards Summary for ADAM11 Gene:
ADAM11 (ADAM metallopeptidase domain 11) is a protein-coding gene. Diseases associated with ADAM11 include breast cancer, and pancreatic cancer. GO annotations related to this gene include metallopeptidase activity and metalloendopeptidase activity. An important paralog of this gene is ADAM32.

UniProtKB/Swiss-Prot: ADA11_HUMAN, O75078
Function: Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein

Gene Wiki entry for ADAM11 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ADAM11 gene promoter:
         Spz1   Pax-2   Pax-2a   AP-2gamma   GATA-1   PPAR-gamma1   AP-2beta   PPAR-gamma2   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidADAM11 promoter sequence
   Search Chromatin IP Primers for ADAM11

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ADAM11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.3   Ensembl cytogenetic band:  17q21.31   HGNC cytogenetic band: 17q21.3

ADAM11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADAM11 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P042847:  view genomic region     (about GC identifiers)

Start:
42,836,399 bp from pter      End:
42,859,214 bp from pter
Size:
22,816 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ADA11_HUMAN, O75078 (See protein sequence)
Recommended Name: Disintegrin and metalloproteinase domain-containing protein 11 precursor  
Size: 769 amino acids; 83418 Da
Subunit: Can bind to LGI1 and LGI4 (By similarity)
Secondary accessions: Q14808 Q14809 Q14810
Alternative splicing: 2 isoforms:  O75078-1   O75078-2   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for ADAM11: NX_O75078

Explore proteomics data for ADAM11 at MOPED

Post-translational modifications: 

  • The precursor is cleaved by a furin endopeptidase (By similarity)1
  • Glycosylation2 at Asn96, Asn163, Asn605, Asn673
  • Modification sites at PhosphoSitePlus

  • See ADAM11 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002381.2  
    ENSEMBL proteins: 
     ENSP00000200557   ENSP00000347856   ENSP00000443773   ENSP00000465537  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ADAM: ADAM metallopeptidase domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: ADAM11
    ADAM

    Selected InterPro protein domains (see all 8):
     IPR024079 MetalloPept_cat_dom
     IPR006586 ADAM_Cys-rich
     IPR000742 EG-like_dom
     IPR018358 Disintegrin_CS
     IPR001762 Blood-coag_inhib_Disintegrin

    Graphical View of Domain Structure for InterPro Entry O75078

    ProtoNet protein and cluster: O75078

    3 Blocks protein domains:
    IPB001762 Disintegrin
    IPB002870 Metalloendopeptidase M12B
    IPB006586 ADAM


    UniProtKB/Swiss-Prot: ADA11_HUMAN, O75078
    Domain: A conserved motif [AVN[ED]CD] within the disintegrin-like domain could be involved in the binding to the
    integrin receptor
    Similarity: Contains 1 disintegrin domain
    Similarity: Contains 1 EGF-like domain
    Similarity: Contains 1 peptidase M12B domain


    ADAM11 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ADA11_HUMAN, O75078
    Function: Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein

         Genatlas biochemistry entry for ADAM11:
    a disintegrin and metalloprotease (inactive) domain 11,membrane anchored cell surface adhesion protein with two
    isoforms MDC-769,MDC-524,highly expressed in the brain,also expressed in somatic tissues

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity IEA--
    GO:0005178integrin binding TAS9693107
    GO:0005515protein binding ----
    GO:0008237metallopeptidase activity TAS9693107
    GO:0008270zinc ion binding IEA--
         
    ADAM11 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Adam11):
     behavior/neurological 

    ADAM11 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Adam11tm1Sag for ADAM11

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ADAM11
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    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ADAM11 (see all 39):
    hsa-miR-219-1-3p hsa-miR-132* hsa-miR-3607-3p hsa-miR-1321 hsa-miR-513a-5p hsa-let-7a-2* hsa-miR-30d hsa-miR-488
    SwitchGear 3'UTR luciferase reporter plasmidADAM11 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for ADAM11
    Predesigned siRNA for gene silencing in human, mouse, rat ADAM11

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    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAM11


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ADA11_HUMAN, O75078: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    cytosol1
    extracellular1
    lysosome1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005886plasma membrane TAS9693107
    GO:0016021integral component of membrane IEA--
    GO:0031012colocalizes with extracellular matrix ISS--

    ADAM11 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ADAM11
    Interactions:

        GeneGlobe Interaction Network for ADAM11

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    3 Interacting proteins for ADAM11 (O750782, 3 ENSP000002005574) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STC2O760612, 3MINT-63200 I2D: score=5 
    YWHABP319463I2D: score=1 
    MPP5ENSP000002616814STRING: ENSP00000261681
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----
    GO:0007229integrin-mediated signaling pathway TAS8252040

    ADAM11 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ADAM11 (ADA11)

    1 Novoseek inferred chemical compound relationship for ADAM11 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mdc-2 91.5 3 10433968 (2)



    ADAM11 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ADAM11 gene: 
    NM_002390.4  

    Unigene Cluster for ADAM11:

    ADAM metallopeptidase domain 11
    Hs.6088  [show with all ESTs]
    Unigene Representative Sequence: NM_002390
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000200557(uc002ihh.3 uc010wjd.2 uc002ihi.3) ENST00000355638
    ENST00000535346 ENST00000587773 ENST00000588363
    miRNA
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    Block miRNA regulation of human, mouse, rat ADAM11 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ADAM11 (see all 39):
    hsa-miR-219-1-3p hsa-miR-132* hsa-miR-3607-3p hsa-miR-1321 hsa-miR-513a-5p hsa-let-7a-2* hsa-miR-30d hsa-miR-488
    SwitchGear 3'UTR luciferase reporter plasmidADAM11 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ADAM11
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    GenScript: all cDNA clones in your preferred vector: ADAM11 (NM_002390)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADAM11
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ADAM11
      QuantiTect SYBR Green Assays in human, mouse, rat ADAM11
      QuantiFast Probe-based Assays in human, mouse, rat ADAM11

    Additional mRNA sequence: 

    AB009675.1 AK296512.1 BC144550.1 D17390.1 

    3 DOTS entries:

    DT.91680801  DT.111546  DT.92326603 

    Selected AceView cDNA sequences (see all 45):

    BM720056 AA339669 BM720462 BX281439 BU739874 NM_021612 CD630840 AI873177 
    BM472328 R85092 BU187486 CD630831 BM727635 BM681070 BI755843 T15471 
    NM_002390 AJ712115 BM557705 AB009675 CD630844 BU740388 CD630835 CD630834 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ADAM11 expression in normal human tissues (normalized intensities)      ADAM11 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGACTTCCTG
    ADAM11 Expression
    About this image


    ADAM11 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 8 entries
             Thalamus
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Mononuclear Myocytes Hyoid Arch Muscles
     
     Blood (Cardiovascular System)
             Conventional Dendritic Cells II Spleen
     
     Eye (Sensory Organs)
             Retina
     
     Spleen (Hematopoietic System)
             Conventional Dendritic Cells II Spleen
    ADAM11 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ADAM11 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.6088

    UniProtKB/Swiss-Prot: ADA11_HUMAN, O75078
    Tissue specificity: Expressed predominantly in brain. Slightly detected or not at all in other tissues

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ADAM11 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adam111 , 5 a disintegrin and metallopeptidase domain 111, 5 89.19(n)1
    95.16(a)1
      11 (66.48 cM)5
    114881  NM_001110778.11  NP_001104248.11 
     1027614395 
    chicken
    (Gallus gallus)
    Aves ADAM111 ADAM metallopeptidase domain 11 75.86(n)
    77.5(a)
      428282  XM_425842.4  XP_425842.4 
    lizard
    (Anolis carolinensis)
    Reptilia ADAM116
    ADAM metallopeptidase domain 11
    72(a)
    1 ↔ 1
    6(63586467-63681664)
    African clawed frog
    (Xenopus laevis)
    Amphibia MDC11a2 metalloprotease/disintegrin xMDC11.1 74.4(n)    AF032384.1 
    zebrafish
    (Danio rerio)
    Actinopterygii adam111 a disintegrin and metalloproteinase domain 11 62.65(n)
    66.11(a)
      567145  XM_690437.5  XP_695529.5 
    fruit fly
    (Drosophila melanogaster)
    Insecta mmd1 , 3 metalloendopeptidase3
    mind-meld1
    33(a)3
    47.85(n)1
    35.74(a)1
      325611  NM_078634.61  NP_523358.51 
    worm
    (Caenorhabditis elegans)
    Secernentea adm-13 Disintegrin 28(a)   III(12952834-12963248)   --


    ENSEMBL Gene Tree for ADAM11 (if available)
    TreeFam Gene Tree for ADAM11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ADAM11 gene
    ADAM322  ADAM232  ADAM182  ADAM222  ADAM22  ADAMDEC12  
    9 SIMAP similar genes for ADAM11 using alignment to 4 protein entries:     ADA11_HUMAN (see all proteins):
    ADAM22    ADAM23    ADAM32    ADAM28    ADAM12    ADAM9
    ADAM15    ADAM19    ADAM7

    ADAM11 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ADAM11 (see all 555)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0626694
    A pancreatic ductal adenocarcinoma sample4--see VAR_0626692 S R mis40--------
    rs1176668751,2
    F--42834581(+) GGAGGA/GCCCAG 1 -- us2k11Minor allele frequency- G:0.07EA 120
    rs1912747681,2
    --42834600(+) AGCCCC/TGGGCT 1 -- us2k10--------
    rs765425621,2
    F--42834645(+) TGGGGG/TGCACT 1 -- us2k11Minor allele frequency- T:0.01WA 118
    rs1467990231,2
    C--42834753(+) CAGATA/GTACCA 1 -- us2k10--------
    rs1405182831,2
    --42835008(+) CCTACA/GTCTTG 1 -- us2k10--------
    rs1823397441,2
    --42835042(+) AGAGCA/GAAGGA 1 -- us2k10--------
    rs1456122581,2
    --42835128(+) CCTACA/GTTGAT 1 -- us2k10--------
    rs348393541,2
    C,F,H--42835129(+) CTACAT/CTGATG 1 -- us2k115Minor allele frequency- C:0.14NS EA WA NA 2336
    rs1877101131,2
    --42835188(+) AGAGCA/GGGGGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ADAM11 (42836399 - 42859214 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ADAM11:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv908286CNV Loss21882294
    nsv833456CNV Gain+Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ADAM11
    DNA2.0 Custom Variant and Variant Library Synthesis for ADAM11

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 155120    OMIM disorders: --

    7 diseases for ADAM11:    About MalaCards
    breast cancer    pancreatic cancer    pancreatitis    malaria
    prostate cancer    prostatitis    cerebritis


    ADAM11 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for ADAM11 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 0 1 7956356 (1)
    tumors 0 3 7956356 (1), 11102971 (1)

    Genetic Association Database (GAD): ADAM11
    Human Genome Epidemiology (HuGE) Navigator: ADAM11 (1 document)

    Export disorders for ADAM11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ADAM11 gene, integrated from 10 sources (see all 25):
    (articles sorted by number of sources associating them with ADAM11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel metalloprotease/disintegrin-like gene at 17q21.3 is somatically rearranged in two primary breast cancers. (PubMed id 8252040)1, 2, 3, 9 Emi M.... Nakamura Y. (Nat. Genet. 1993)
    2. Human metalloprotease/disintegrin-like (MDC) gene: exon-intron organization and alternative splicing. (PubMed id 7956356)1, 2, 9 Katagiri T.... Nakamura Y. (Cytogenet. Cell Genet. 1995)
    3. Metalloproteinase-like, disintegrin-like, cysteine-rich proteins MDC2 and MDC3: novel human cellular disintegrins highly expressed in the brain. (PubMed id 9693107)1, 2, 9 Sagane K.... Tanaka I. (Biochem. J. 1998)
    4. An unappreciated role for RNA surveillance. (PubMed id 14759258)1, 2 Hillman R.T.... Brenner S.E. (Genome Biol. 2004)
    5. ADH2 and alcohol-related phenotypes in Ashkenazic Jewish American college students. (PubMed id 11545539)1, 4 Shea S.H....Li T.K. (Behav. Genet. 2001)
    6. Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. (PubMed id 18772397)2 Jones S.... Kinzler K.W. (Science 2008)
    7. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (Cell 2005)
    8. Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes. (PubMed id 15203218)1 Fu G.K....Stuve L.L. (Genomics 2004)
    9. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (Nat. Biotechnol. 2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4185 HGNC: 189 AceView: ADAM11 Ensembl:ENSG00000073670 euGenes: HUgn4185
    ECgene: ADAM11 H-InvDB: ADAM11

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ADAM11 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ADAM11 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ADAM11 gene:
    Search GeneIP for patents involving ADAM11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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