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Aliases for ADAM11 Gene

Aliases for ADAM11 Gene

  • ADAM Metallopeptidase Domain 11 2 3 5
  • Metalloproteinase-Like, Disintegrin-Like, And Cysteine-Rich Protein 3 4
  • ADAM 11 3 4
  • MDC 3 4
  • Metalloproteinase-Like, Disintegrin-Like, Cysteine-Rich Protein 2
  • Disintegrin And Metalloproteinase Domain-Containing Protein 11 3
  • A Disintegrin And Metalloproteinase Domain 11 2

External Ids for ADAM11 Gene

Previous HGNC Symbols for ADAM11 Gene

  • MDC

Previous GeneCards Identifiers for ADAM11 Gene

  • GC17P042355
  • GC17P045013
  • GC17P042847
  • GC17P043313
  • GC17P043286
  • GC17P040192
  • GC17P038601

Summaries for ADAM11 Gene

Entrez Gene Summary for ADAM11 Gene

  • This gene encodes a member of the ADAM (a disintegrin and metalloprotease) protein family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature protease. This gene represents a candidate tumor suppressor gene for human breast cancer based on its location within a minimal region of chromosome 17q21 previously defined by tumor deletion mapping. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]

GeneCards Summary for ADAM11 Gene

ADAM11 (ADAM Metallopeptidase Domain 11) is a Protein Coding gene. Among its related pathways are LGI-ADAM interactions and Developmental Biology. GO annotations related to this gene include metalloendopeptidase activity and metallopeptidase activity. An important paralog of this gene is ADAM22.

UniProtKB/Swiss-Prot for ADAM11 Gene

  • Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein.

Gene Wiki entry for ADAM11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAM11 Gene

Genomics for ADAM11 Gene

Regulatory Elements for ADAM11 Gene

Enhancers for ADAM11 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F044781 0.8 Ensembl ENCODE 20.4 +23.2 23165 1.7 KLF1 ZNF341 GLIS1 GABPB1 FOXP2 REST ZNF18 ADAM11 DBF4B GJC1 HIGD1B CCDC103 EFTUD2 FAM187A ENSG00000224911 GFAP MEIOC
GH17F044607 1.2 Ensembl ENCODE 10.1 -150.3 -150347 1.8 ELF3 MLX ZFP64 ARID4B DMAP1 RAD21 RARA MIXL1 EGR2 SP5 DBF4B ADAM11 FAM187A ENSG00000271222 GC17P044631
GH17F044541 2 VISTA FANTOM5 Ensembl ENCODE 4.3 -213.8 -213817 8.1 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A SLC30A9 ZNF766 ZNF143 FOS GPATCH8 MEIOC FAM171A2 SLC25A39 TMUB2 FZD2 GRN ADAM11 TMEM101 GJC1
GH17F044603 1 ENCODE 6.3 -154.1 -154145 1.8 HDGF ARID4B DMAP1 YBX1 ZNF2 ZNF48 ZNF121 ZNF143 ZNF207 KLF7 DBF4B ASB16-AS1 GJC1 LINC01180 FAM187A ADAM11 EFTUD2 ENSG00000271222 GC17P044631
GH17F044957 0.8 FANTOM5 5.4 +198.8 198755 0.4 BCOR SAP130 ZMYM3 DMAP1 ZIC2 ZNF644 HBP1 KAT8 GLIS1 PATZ1 GFAP HIGD1B ADAM11 ACBD4 DCAKD GC17P044955 C1QL1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ADAM11 on UCSC Golden Path with GeneCards custom track

Promoters for ADAM11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001807466 -31 801 KLF1 KLF17 HIC1 ZFHX2 GLIS2 POLR2A PATZ1 ZNF547 EZH2 EGR2

Genomic Location for ADAM11 Gene

Chromosome:
17
Start:
44,759,031 bp from pter
End:
44,781,846 bp from pter
Size:
22,816 bases
Orientation:
Plus strand

Genomic View for ADAM11 Gene

Genes around ADAM11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADAM11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADAM11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAM11 Gene

Proteins for ADAM11 Gene

  • Protein details for ADAM11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75078-ADA11_HUMAN
    Recommended name:
    Disintegrin and metalloproteinase domain-containing protein 11
    Protein Accession:
    O75078
    Secondary Accessions:
    • Q14808
    • Q14809
    • Q14810

    Protein attributes for ADAM11 Gene

    Size:
    769 amino acids
    Molecular mass:
    83418 Da
    Quaternary structure:
    • Can bind to LGI1 and LGI4.

    Alternative splice isoforms for ADAM11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADAM11 Gene

Post-translational modifications for ADAM11 Gene

  • The precursor is cleaved by a furin endopeptidase.
  • Glycosylation at Asn 96, Asn 163, Asn 605, and Asn 673
  • Modification sites at PhosphoSitePlus

Other Protein References for ADAM11 Gene

No data available for DME Specific Peptides for ADAM11 Gene

Domains & Families for ADAM11 Gene

Gene Families for ADAM11 Gene

Graphical View of Domain Structure for InterPro Entry

O75078

UniProtKB/Swiss-Prot:

ADA11_HUMAN :
  • A conserved motif [AVN[ED]CD] within the disintegrin-like domain could be involved in the binding to the integrin receptor.
Domain:
  • A conserved motif [AVN[ED]CD] within the disintegrin-like domain could be involved in the binding to the integrin receptor.
  • Contains 1 disintegrin domain.
  • Contains 1 EGF-like domain.
  • Contains 1 peptidase M12B domain.
genes like me logo Genes that share domains with ADAM11: view

Function for ADAM11 Gene

Molecular function for ADAM11 Gene

GENATLAS Biochemistry:
a disintegrin and metalloprotease (inactive) domain 11,membrane anchored cell surface adhesion protein with two isoforms MDC-769,MDC-524,highly expressed in the brain,also expressed in somatic tissues
UniProtKB/Swiss-Prot Function:
Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein.

Gene Ontology (GO) - Molecular Function for ADAM11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA --
GO:0005178 integrin binding TAS 9693107
GO:0008237 metallopeptidase activity IEA,TAS 9693107
genes like me logo Genes that share ontologies with ADAM11: view
genes like me logo Genes that share phenotypes with ADAM11: view

Animal Models for ADAM11 Gene

MGI Knock Outs for ADAM11:

Animal Model Products

  • Taconic Biosciences Mouse Models for ADAM11

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADAM11 Gene

Localization for ADAM11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADAM11 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADAM11 gene
Compartment Confidence
plasma membrane 5
nucleus 3
cytosol 2
extracellular 1
mitochondrion 1
peroxisome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for ADAM11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031012 colocalizes_with extracellular matrix ISS 22261194
genes like me logo Genes that share ontologies with ADAM11: view

Pathways & Interactions for ADAM11 Gene

genes like me logo Genes that share pathways with ADAM11: view

Pathways by source for ADAM11 Gene

2 Reactome pathways for ADAM11 Gene

Interacting Proteins for ADAM11 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000200557%0d%0a9606.ENSP00000293813%0d%0a9606.ENSP00000365272%0d%0a
Selected Interacting proteins: O75078-ADA11_HUMAN ENSP00000200557 for ADAM11 Gene via IID STRING

Gene Ontology (GO) - Biological Process for ADAM11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0007229 integrin-mediated signaling pathway IEA,TAS 8252040
genes like me logo Genes that share ontologies with ADAM11: view

No data available for SIGNOR curated interactions for ADAM11 Gene

Drugs & Compounds for ADAM11 Gene

(1) Additional Compounds for ADAM11 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ADAM11: view

Transcripts for ADAM11 Gene

Unigene Clusters for ADAM11 Gene

ADAM metallopeptidase domain 11:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADAM11 Gene

No ASD Table

Relevant External Links for ADAM11 Gene

GeneLoc Exon Structure for
ADAM11
ECgene alternative splicing isoforms for
ADAM11

Expression for ADAM11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ADAM11 Gene

mRNA differential expression in normal tissues according to GTEx for ADAM11 Gene

This gene is overexpressed in Brain - Cerebellum (x11.2), Brain - Cerebellar Hemisphere (x9.0), Brain - Cortex (x6.6), Brain - Frontal Cortex (BA9) (x4.6), and Brain - Anterior cingulate cortex (BA24) (x4.0).

Protein differential expression in normal tissues from HIPED for ADAM11 Gene

This gene is overexpressed in Frontal cortex (62.6) and Fetal Brain (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADAM11 Gene



Protein tissue co-expression partners for ADAM11 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ADAM11 Gene:

ADAM11

SOURCE GeneReport for Unigene cluster for ADAM11 Gene:

Hs.6088

mRNA Expression by UniProt/SwissProt for ADAM11 Gene:

O75078-ADA11_HUMAN
Tissue specificity: Expressed predominantly in brain. Slightly detected or not at all in other tissues.
genes like me logo Genes that share expression patterns with ADAM11: view

Primer Products

Orthologs for ADAM11 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADAM11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADAM11 34 35
  • 99.33 (n)
dog
(Canis familiaris)
Mammalia ADAM11 34 35
  • 90.34 (n)
cow
(Bos Taurus)
Mammalia ADAM11 34 35
  • 90.28 (n)
rat
(Rattus norvegicus)
Mammalia Adam11 34
  • 89.88 (n)
mouse
(Mus musculus)
Mammalia Adam11 34 16 35
  • 89.19 (n)
oppossum
(Monodelphis domestica)
Mammalia ADAM11 35
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 50 (a)
ManyToMany
chicken
(Gallus gallus)
Aves ADAM11 34 35
  • 75.86 (n)
lizard
(Anolis carolinensis)
Reptilia ADAM11 35
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia adam11 34
  • 66.34 (n)
African clawed frog
(Xenopus laevis)
Amphibia MDC11a 34
zebrafish
(Danio rerio)
Actinopterygii adam11 34 35
  • 62.65 (n)
fruit fly
(Drosophila melanogaster)
Insecta mmd 36 34 35
  • 47.85 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000974 34
  • 46.41 (n)
worm
(Caenorhabditis elegans)
Secernentea adm-1 36
  • 28 (a)
unc-71 35
  • 19 (a)
OneToMany
Species where no ortholog for ADAM11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADAM11 Gene

ENSEMBL:
Gene Tree for ADAM11 (if available)
TreeFam:
Gene Tree for ADAM11 (if available)

Paralogs for ADAM11 Gene

(9) SIMAP similar genes for ADAM11 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ADAM11: view

Variants for ADAM11 Gene

Sequence variations from dbSNP and Humsavar for ADAM11 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
VAR_062669 A pancreatic ductal adenocarcinoma sample
rs11079349 -- 44,778,713(+) AAAAA(A/G)GAAAG intron-variant
rs112200007 -- 44,774,097(+) AAAGA(-/AAAAAG)AAAAA intron-variant
rs112667715 -- 44,769,627(+) CCCCT(-/T)CCCCA intron-variant
rs112676544 -- 44,781,393(+) CTCCG(C/G)CCAGC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ADAM11 Gene

Variant ID Type Subtype PubMed ID
esv3554459 CNV deletion 23714750
esv3893016 CNV loss 25118596
nsv1067206 CNV gain 25217958
nsv1146669 OTHER inversion 26484159
nsv833456 CNV gain+loss 17160897

Variation tolerance for ADAM11 Gene

Residual Variation Intolerance Score: 14.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.06; 37.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADAM11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADAM11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADAM11 Gene

Disorders for ADAM11 Gene

Relevant External Links for ADAM11

Genetic Association Database (GAD)
ADAM11
Human Genome Epidemiology (HuGE) Navigator
ADAM11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADAM11

No disorders were found for ADAM11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADAM11 Gene

Publications for ADAM11 Gene

  1. A novel metalloprotease/disintegrin-like gene at 17q21.3 is somatically rearranged in two primary breast cancers. (PMID: 8252040) Emi M. … Nakamura Y. (Nat. Genet. 1993) 2 3 4 22 64
  2. Metalloproteinase-like, disintegrin-like, cysteine-rich proteins MDC2 and MDC3: novel human cellular disintegrins highly expressed in the brain. (PMID: 9693107) Sagane K. … Tanaka I. (Biochem. J. 1998) 3 4 22 64
  3. Human metalloprotease/disintegrin-like (MDC) gene: exon-intron organization and alternative splicing. (PMID: 7956356) Katagiri T. … Nakamura Y. (Cytogenet. Cell Genet. 1995) 3 4 22 64
  4. An unappreciated role for RNA surveillance. (PMID: 14759258) Hillman R.T. … Brenner S.E. (Genome Biol. 2004) 3 4 64
  5. ADH2 and alcohol-related phenotypes in Ashkenazic Jewish American college students. (PMID: 11545539) Shea S.H. … Li T.K. (Behav. Genet. 2001) 3 46 64

Products for ADAM11 Gene

Sources for ADAM11 Gene

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