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ADAM10 Gene

protein-coding   GIFtS: 74
GCID: GC15M058887

ADAM Metallopeptidase Domain 10

(Previous name: a disintegrin and metalloproteinase domain 10)
Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ADAM Metallopeptidase Domain 101 2     CD156c2
MADM2 3 5     HsT187172
Kuzbanian Protein Homolog2 3     A Disintegrin And Metalloprotease Domain 102
Mammalian Disintegrin-Metalloprotease2 3     Disintegrin And Metalloproteinase Domain-Containing Protein 102
CDw1562 3     kuz2
EC 3.4.24.813 8     KUZ3
AD182 5     ADAM 103
RAK2 5     CD156c Antigen3
A Disintegrin And Metalloproteinase Domain 101     EC 3.4.248
AD102     

External Ids:    HGNC: 1881   Entrez Gene: 1022   Ensembl: ENSG000001378457   OMIM: 6021925   UniProtKB: O146723   

Export aliases for ADAM10 gene to outside databases

Previous GC identifers: GC15M054446 GC15M051936 GC15M056466 GC15M056605 GC15M056566 GC15M056676 GC15M035711


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ADAM10 Gene:
Members of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion
and protease domains. This gene encodes and ADAM family member that cleaves many proteins including TNF-alpha and
E-cadherin. (provided by RefSeq, Jul 2008)

GeneCards Summary for ADAM10 Gene:
ADAM10 (ADAM metallopeptidase domain 10) is a protein-coding gene. Diseases associated with ADAM10 include alzheimer disease 18, and dowling-degos disease. GO annotations related to this gene include protein homodimerization activity and receptor binding. An important paralog of this gene is ADAM17.

UniProtKB/Swiss-Prot: ADA10_HUMAN, O14672
Function: Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala- -Val-77' to its mature soluble form.
Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the
proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like
factor, ephrin-A2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP).
Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion
molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity.
Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis.
Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL
APL) transmembrane form. Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B. May
regulate the EFNA5-EPHA3 signaling

Gene Wiki entry for ADAM10 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000015.10  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ADAM10 gene promoter:
         AhR   Pbx1a   AP-1   ATF-2   c-Jun   AP-2gamma   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidADAM10 promoter sequence
   Search Chromatin IP Primers for ADAM10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ADAM10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q22   Ensembl cytogenetic band:  15q21.3   HGNC cytogenetic band: 15q2

ADAM10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADAM10 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M058887:  view genomic region     (about GC identifiers)

Start:
58,887,403 bp from pter      End:
59,042,177 bp from pter
Size:
154,775 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ADA10_HUMAN, O14672 (See protein sequence)
Recommended Name: Disintegrin and metalloproteinase domain-containing protein 10 precursor  
Size: 748 amino acids; 84142 Da
Cofactor: Binds 1 zinc ion (By similarity)
Subunit: Interacts with EPHA2 (By similarity). Forms a ternary EFNA5-EPHA3-ADAM10 complex mediating EFNA5
extracellular domain shedding by ADAM10 which regulates the EFNA5-EPHA3 complex internalization and function, the
cleavage occurs in trans, with ADAM10 and its substrate being on the membranes of opposing cells
1 PDB 3D structure from and Proteopedia for ADAM10:
1M1I (3D)    
Secondary accessions: Q10742 Q92650

Explore the universe of human proteins at neXtProt for ADAM10: NX_O14672

Explore proteomics data for ADAM10 at MOPED

Post-translational modifications: 

  • The precursor is cleaved by a furin endopeptidase (By similarity)1
  • Ubiquitination2 at Lys410, Lys601
  • Glycosylation2 at Ser36, Thr130, Asn267, Asn278, Asn439, Asn551
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for ADAM10 (O14672) (see all 14)
     TCASTGS  YQMGHMR  GEECDCG  IQTDHLF 


    See ADAM10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001101.1  
    ENSEMBL proteins: 
     ENSP00000260408   ENSP00000386056   ENSP00000452639   ENSP00000456542   ENSP00000453952  
     ENSP00000391930   ENSP00000452704   ENSP00000379444  
    Reactome Protein details: O14672

    ADAM10 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for ADAM10
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for ADAM10
    GenScript Custom Purified and Recombinant Proteins Services for ADAM10
    Novus Biologicals ADAM10 Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for ADAM10
    Cloud-Clone Corp. Proteins for ADAM10

    ADAM10 Antibody Products:

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    Novus Biologicals ADAM10 Antibodies
    Abcam antibodies for ADAM10
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    ThermoFisher Antibodies for ADAM10
    LSBio Antibodies in human, mouse, rat for ADAM10

    ADAM10 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for ADAM10
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    Cloud-Clone Corp. ELISAs for ADAM10
    Cloud-Clone Corp. CLIAs for ADAM10


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    ADAM: ADAM metallopeptidase domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: ADAM10
    ADAM

    5 InterPro protein domains:
     IPR024079 MetalloPept_cat_dom
     IPR027053 ADAM_10
     IPR001762 Blood-coag_inhib_Disintegrin
     IPR001590 Peptidase_M12B
     IPR002870 Peptidase_M12B_N

    Graphical View of Domain Structure for InterPro Entry O14672

    ProtoNet protein and cluster: O14672

    1 Blocks protein domain: IPB001762 Disintegrin

    UniProtKB/Swiss-Prot: ADA10_HUMAN, O14672
    Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting
    the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the
    enzyme
    Domain: The Cys-rich region C-terminal to the disintegrin domain functions as a substrate-recognition module, it
    recognizes the EFNA5-EPHA3 Complex but not the individual proteins (By similarity)
    Similarity: Contains 1 disintegrin domain
    Similarity: Contains 1 peptidase M12B domain


    ADAM10 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ADA10_HUMAN, O14672
    Function: Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala- -Val-77' to its mature soluble form.
    Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the
    proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like
    factor, ephrin-A2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP).
    Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion
    molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity.
    Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis.
    Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL
    APL) transmembrane form. Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B. May
    regulate the EFNA5-EPHA3 signaling
    Catalytic activity: Endopeptidase of broad specificity
    Induction: In osteoarthritis affected-cartilage

         Genatlas biochemistry entry for ADAM10:
    a disintegrin and metalloprotease (active) domain 10,membrane anchored,cell surface adhesion protein with a
    shorter alternatively spliced form,homolog to Drosophila Kuzbanian gene,expressed in articular cartilage and
    metaphyseal bone,involved in cell-cell and cell-matrix interactions,regulating sympathoadrenal cell fate in
    development and neoplasia,maybe presenting alpha secretase activity,involved in the proteolytic processing of APP

         Enzyme Numbers (IUBMB): EC 3.4.24.811 2 EC 3.4.242

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004175endopeptidase activity ISS--
    GO:0004222metalloendopeptidase activity NAS8694785
    GO:0005102receptor binding NAS12176995
    GO:0005178integrin binding NAS8694785
    GO:0005515protein binding IPI10527948
         
    ADAM10 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for ADAM10:
     Decreased Salmonella enterica   Decreased Tat-dependent transc  Decreased p24 protein expressi 

         13 MGI mutant phenotypes (inferred from 7 alleles(MGI details for Adam10):
     cardiovascular system  cellular  craniofacial  digestive/alimentary  embryogenesis 
     growth/size/body  hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 
     nervous system  normal  skeleton 

    ADAM10 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for ADAM10: Adam10tm1Psa Adam10tm1.1Zhu

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ADAM10
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ADAM10

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ADAM10
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ADAM10

    miRNA
    Products:
        
    miRTarBase miRNAs that target ADAM10:
    hsa-mir-122-5p (MIRT004879), hsa-mir-155-5p (MIRT021045), hsa-mir-484 (MIRT041888)

    Block miRNA regulation of human, mouse, rat ADAM10 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ADAM10 (see all 35):
    hsa-miR-140-5p hsa-miR-25 hsa-miR-374a hsa-miR-374c hsa-miR-9 hsa-miR-3148 hsa-miR-4309 hsa-miR-192*
    SwitchGear 3'UTR luciferase reporter plasmidADAM10 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ADAM10
    Predesigned siRNA for gene silencing in human, mouse, rat ADAM10

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for ADAM10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ADAM10 (NM_001110)
    Sino Biological Human cDNA Clone for ADAM10
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADAM10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADAM10

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAM10


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ADA10_HUMAN, O14672: Cell membrane; Single-pass type I membrane protein. Endomembrane system; Single-pass type I
    membrane protein. Note=Is localized in the plasma membrane but is predominantly expressed in the Golgi apparatus
    and in released membrane vesicles derived likely from the Golgi
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    plasma membrane5
    nucleus4
    cytoskeleton2
    extracellular2
    endoplasmic reticulum1
    endosome1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005737cytoplasm ISS--
    GO:0005794Golgi apparatus IDA12475894
    GO:0005798Golgi-associated vesicle IDA12475894
    GO:0005886plasma membrane TAS--

    ADAM10 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ADAM10 About   (see all 19)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Notch signaling pathway (KEGG)
    Delta-Notch Signaling Pathway0.33
    Signaling by NOTCH40.00
    Signaling by NOTCH30.00
    2Alzheimer's disease
    Alzheimers Disease0.44
    Alzheimer's disease0.44
    3Signaling by NOTCH1 PEST Domain Mutants in Cancer
    Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants0.79
    Signaling by NOTCH1 HD Domain Mutants in Cancer0.79
    Signaling by NOTCH1 PEST Domain Mutants in Cancer0.79
    Constitutive Signaling by NOTCH1 PEST Domain Mutants0.79
    Signaling by NOTCH1 in Cancer0.79
    Signaling by NOTCH1 t(7;9)(NOTCH1-M1580 K2555) Translocation Mutant0.79
    Signaling by NOTCH10.79
    FBXW7 Mutants and NOTCH1 in Cancer0.79
    4Signaling by NOTCH2
    NOTCH2 Activation and Transmission of Signal to the Nucleus0.67
    Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1-M1580_K2555) Translocation Mutant0.00
    Signaling by NOTCH20.67
    Constitutive Signaling by NOTCH1 HD Domain Mutants0.00
    Activated NOTCH1 Transmits Signal to the Nucleus0.61
    5Degradation of the extracellular matrix
    Degradation of the extracellular matrix0.43
    Extracellular matrix organization0.34
    Collagen degradation0.43

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for ADAM10
        A-beta Plaque Formation & APP Metabolism

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ADAM10
        Inhibition of Matrix Metalloproteinases
    Alzheimers Disease Pathway
    EphrinA-EphR Signaling

    2 GeneGo (Thomson Reuters) Pathways for ADAM10
        Immune response IL-6 signaling pathway
    Cell adhesion Ephrins signaling

    5 BioSystems Pathways for ADAM10
        Hypertrophy Model
    Delta-Notch Signaling Pathway
    Alzheimers Disease
    Presenilin action in Notch and Wnt signaling
    Notch signaling pathway

    1 Sino Biological Pathway for ADAM10
        Notch Signaling Pathway

    Selected Reactome Pathways for ADAM10 (see all 11)
        Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
    Collagen degradation
    NOTCH2 Activation and Transmission of Signal to the Nucleus
    Constitutive Signaling by NOTCH1 t(7 9)(NOTCH1:M1580_K2555) Translocation Mutant
    Signaling by NOTCH4


    2 Kegg Pathways  (Kegg details for ADAM10):
        Alzheimer's disease
    Epithelial cell signaling in Helicobacter pylori infection


    ADAM10 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ADAM10: 
              Alzheimer's Disease in human mouse rat
              Notch Signaling Pathway in human mouse rat
              Synaptic Plasticity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ADAM10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ADAM10 (O146722, 3 ENSP000002604084) via UniProtKB, MINT, STRING, and/or I2D (see all 74)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PDIA3P301012, 3MINT-4301297 I2D: score=1 
    EFNA2O439213, ENSP000002153684I2D: score=3 STRING: ENSP00000215368
    ARP102753, ENSP000003638224I2D: score=1 STRING: ENSP00000363822
    EFNA1P208273, ENSP000003573924I2D: score=1 STRING: ENSP00000357392
    LCKP062393, ENSP000003378254I2D: score=1 STRING: ENSP00000337825
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 21):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001701in utero embryonic development ISS--
    GO:0006468protein phosphorylation ISS--
    GO:0006508proteolysis ----
    GO:0006509membrane protein ectodomain proteolysis IMP17965014
    GO:0007162negative regulation of cell adhesion NAS8694785

    ADAM10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
    1 ApexBio Compound for ADAM10     About this table
    CompoundAction CAS #
    GI 254023XSelective ADAM10 metalloprotease inhibitor[260264-93-5]

    Browse Tocris compounds for ADAM10 (ADA10)

    9 Novoseek inferred chemical compound relationships for ADAM10 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hydroxamate 46.5 5 15777180 (2), 15128827 (1), 10818225 (1)
    dihydrotestosterone 32.5 6 14734484 (3), 17727679 (2), 11000516 (1)
    retinoic acid 27.4 6 17047365 (1), 17908044 (1), 17986385 (1), 15972296 (1) (see all 5)
    tyrosine 9.7 1 19823572 (1)
    zinc 4.23 1 15787600 (1)
    cholesterol 0 2 12832423 (2)
    oligonucleotide 0 3 16309826 (1), 15182369 (1)
    calcium 0 1 16687212 (1)
    nmda 0 1 16687212 (1)



    ADAM10 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ADAM10 gene: 
    NM_001110.3  

    Unigene Cluster for ADAM10:

    ADAM metallopeptidase domain 10
    Hs.578508  [show with all ESTs]
    Unigene Representative Sequence: NM_001110
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000260408(uc002afd.1 uc010bgc.1 uc010ugz.1 uc002afe.1)
    ENST00000402627 ENST00000561288 ENST00000482945 ENST00000396136 ENST00000470269(uc002aff.1)
    ENST00000462061 ENST00000481164 ENST00000475898 ENST00000559053 ENST00000558733
    ENST00000439637 ENST00000497846 ENST00000558004 ENST00000560608 ENST00000561149
    ENST00000461408 ENST00000396140
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ADAM10 (see all 35):
    hsa-miR-140-5p hsa-miR-25 hsa-miR-374a hsa-miR-374c hsa-miR-9 hsa-miR-3148 hsa-miR-4309 hsa-miR-192*
    SwitchGear 3'UTR luciferase reporter plasmidADAM10 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ADAM10
    Clone
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    OriGene ORF clones in mouse, rat for ADAM10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ADAM10 (NM_001110)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADAM10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADAM10
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ADAM10
      QuantiTect SYBR Green Assays in human, mouse, rat ADAM10
      QuantiFast Probe-based Assays in human, mouse, rat ADAM10

    Additional mRNA sequence: 

    AF009615.1 AK023460.1 AK300472.1 BC055087.1 BC104659.1 BC126253.1 BC143935.1 Z48579.1 

    17 DOTS entries:

    DT.100864836  DT.92448214  DT.86850947  DT.100796140  DT.100764133  DT.95242484  DT.91899409  DT.86849431 
    DT.100796137  DT.121064546  DT.95242343  DT.121064539  DT.121064534  DT.406085  DT.95242499  DT.121064521 
    DT.121064548 

    Selected AceView cDNA sequences (see all 279):

    AK023460 AW197000 AA812209 AW515569 BQ681504 AA131556 AL047285 AI094258 
    BQ423636 BF590426 AU135168 AW117725 BQ425786 BM967128 BE219541 BM931211 
    BE551171 AL521862 AI452387 AI915503 CD678645 AL701538 BG286626 AA243020 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ADAM10 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^
    SP1:                          -           -     -     -                 -                                                                                       
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                          -     -     -     -     -     -     -     -     -     -     -     -                 -     -     -     -     -     -     -     -   
    SP5:                                                                                                                                                            

    ExUns: 21a · 21b · 21c · 21d · 21e
    SP1:                              
    SP2:                              
    SP3:                              
    SP4:  -                           
    SP5:                              


    ECgene alternative splicing isoforms for ADAM10

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ADAM10 expression in normal human tissues (normalized intensities)      ADAM10 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATTTCTTAC
    ADAM10 Expression
    About this image


    ADAM10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Retina
     
     Ovary (Reproductive System)
             Ovarian Somatic Cells Ovigerous Cord
    ADAM10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ADAM10 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.578508

    UniProtKB/Swiss-Prot: ADA10_HUMAN, O14672
    Tissue specificity: Expressed in spleen, lymph node, thymus, peripheral blood leukocyte, bone marrow, cartilage,
    chondrocytes and fetal liver

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ADAM10: 
              Alzheimer's Disease in human mouse rat
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              Synaptic Plasticity in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ADAM10 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adam101 , 5 a disintegrin and metallopeptidase domain 101, 5 91.14(n)1
    96.34(a)1
      9 (39.53 cM)5
    114871  NM_007399.31  NP_031425.21 
     706789975 
    chicken
    (Gallus gallus)
    Aves ADAM101 ADAM metallopeptidase domain 10 83.61(n)
    90.22(a)
      374113  NM_204261.2  NP_989592.2 
    lizard
    (Anolis carolinensis)
    Reptilia ADAM106
    ADAM metallopeptidase domain 10
    87(a)
    1 ↔ 1
    GL343573.1(210202-239412)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.70652 Xenopus laevis metalloprotease/disintegrin (ADAM10) more 79.21(n)    AF508151.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc642032 hypothetical protein MGC64203 72.16(n)   393392  BC054638.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG19643 metalloendopeptidase 49(a)
    (best of 2)
      99B9   --
    worm
    (Caenorhabditis elegans)
    Secernentea sup-173 Zinc-binding metalloprotease domain 38(a)   I(8801158-8804870)   --


    ENSEMBL Gene Tree for ADAM10 (if available)
    TreeFam Gene Tree for ADAM10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ADAM10 gene
    ADAM172  
    4 SIMAP similar genes for ADAM10 using alignment to 10 protein entries:     ADA10_HUMAN (see all proteins):
    BCL2L14    VPS18    VPS45    FBXO16

    ADAM10 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ADAM10 (see all 3353)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0663094
    A cutaneous metastatic melanoma sample4--see VAR_0663092 H Y mis40--------
    rs1864171111,2
    --58888060(+) AAGCAA/GTTACA 1 -- ds50010--------
    rs1463820351,2
    C--58888069(+) CATACA/CTATCT 1 -- ds50010--------
    rs1925073221,2
    --58888090(+) TTGTTG/TAGAAT 1 -- ds50010--------
    rs1142639141,2
    F--58888218(+) ATTTTC/ATCTAG 1 -- ds50011Minor allele frequency- A:0.02WA 118
    rs740169441,2
    C--58888297(+) AAAAAG/AGAAAA 1 -- ds50011Minor allele frequency- A:0.50WA 2
    rs617086481,2
    C--58888299(+) AAAGG-/AAAAAA 1 -- ds50010--------
    rs740169451,2
    C--58888299(+) AAAGGG/AAAAAA 1 -- ds50011Minor allele frequency- A:0.50WA 2
    rs1825060381,2
    --58888404(+) TGTAGC/TTGGAA 1 -- ds50010--------
    rs1879189891,2
    --58888415(+) AACAGA/GAGCAA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for ADAM10 (58887403 - 59042177 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ADAM10 (see all 14):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2129733CNV Deletion18987734
    esv1010091CNV Deletion20482838
    esv2749743CNV Deletion23290073
    esv4784CNV Deletion18987735
    esv1712574CNV Deletion17803354
    esv2561717CNV Deletion19546169
    esv2675977CNV Deletion23128226
    esv5828CNV Loss19470904
    nsv1551CNV Loss18451855
    nsv518097CNV Loss19592680

    Human Gene Mutation Database (HGMD): ADAM10
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ADAM10
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602192   
    OMIM disorders: 615537  615590  
    Selected diseases for ADAM10 (see all 54):    About MalaCards
    alzheimer disease 18    dowling-degos disease    scrapie    anoxia
    amyloidosis    adenoid cystic carcinoma    adenoiditis    conduct disorder
    down syndrome    mantle cell lymphoma    osteoarthritis    alzheimer's disease
    narcolepsy    prostate adenocarcinoma    diabetic nephropathy    eclampsia
    pre-eclampsia    basal cell carcinoma    pituitary adenoma    dilated cardiomyopathy

    1 disease from the University of Copenhagen DISEASES database for ADAM10:
    Alzheimer's disease

    ADAM10 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for ADAM10 gene (see all 16)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    alzheimers disease 67.5 21 19234765 (2), 19221420 (2), 17047365 (1), 19608551 (1) (see all 13)
    necrosis 42.1 15 11334139 (2), 20136654 (1), 12730960 (1), 12736275 (1) (see all 14)
    cognitive deficit 36.3 2 19221420 (1)
    tumors 32.3 29 18676862 (3), 18289051 (2), 11334139 (2), 14532978 (2) (see all 19)
    down syndrome 29.5 4 19234765 (2)
    cancer 28 17 18289051 (3), 19783906 (2), 19408347 (2), 15739225 (1) (see all 12)
    inflammation 16.2 6 18276079 (2), 15128827 (1)
    metastasis 13.1 13 19865098 (3), 17699774 (2)
    carcinoma renal cell 11.7 6 19070478 (2), 19190330 (1)
    colon cancer 7.52 8 17699774 (2)

    Genetic Association Database (GAD): ADAM10
    Human Genome Epidemiology (HuGE) Navigator: ADAM10 (12 documents)

    Export disorders for ADAM10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ADAM10 gene, integrated from 10 sources (see all 294):
    (articles sorted by number of sources associating them with ADAM10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. ADAM-10 protein is present in human articular cartilage primarily in the membrane-bound form and is upregulated in osteoarthritis and in response to IL-1alpha in bovine nasal cartilage. (PubMed id 11511685)1, 2, 9 Chubinskaya S.... Tindal M.H. (J. Histochem. Cytochem. 2001)
    2. Molecular cloning of MADM: a catalytically active mammalian disintegrin-metalloprotease expressed in various cell types. (PubMed id 8694785)1, 2, 9 Howard L.... Glynn P. (Biochem. J. 1996)
    3. Variation at the ADAM10 gene locus is not associated with Creutzfeldt-Jakob disease. (PubMed id 12782344)1, 4, 9 Plamont M.A....Laplanche J.L. (Neurosci. Lett. 2003)
    4. Adam meets Eph: an ADAM substrate recognition module acts as a molecular switch for ephrin cleavage in trans. (PubMed id 16239146)1, 2, 9 Janes P.W.... Nikolov D.B. (Cell 2005)
    5. Platelet-activating factor receptor and ADAM10 mediate responses to Staphylococcus aureus in epithelial cells. (PubMed id 11786905)1, 2, 9 Lemjabbar H. and Basbaum C. (Nat. Med. 2002)
    6. Lack of evidence to support the association of polymorphisms within the alpha- and beta-secretase genes (ADAM10/BACE1) with Alzheimer's disease. (PubMed id 19344981)1, 4 Laws S.M....Riemenschneider M. (Neurobiol. Aging 2011)
    7. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    8. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PubMed id 20677014)1, 4 Shimada M....Tokunaga K. (Hum. Genet. 2010)
    9. Genome-wide scan of 500,000 single-nucleotide polymorphisms among responders and nonresponders to interferon beta therapy in multiple sclerosis. (PubMed id 19667218)1, 4 Comabella M....Montalban X. (Arch. Neurol. 2009)
    10. Substrate requirements for SPPL2b-dependent regulated intramembrane proteolysis. (PubMed id 19114711)1, 2 Martin L.... Haass C. (J. Biol. Chem. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 102 HGNC: 188 AceView: ADAM10 Ensembl:ENSG00000137845 euGenes: HUgn102
    ECgene: ADAM10 Kegg: 102 H-InvDB: ADAM10

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ADAM10 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ADAM10 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ADAM10 gene:
    Search GeneIP for patents involving ADAM10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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