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Aliases for ADAM10 Gene

Aliases for ADAM10 Gene

  • ADAM Metallopeptidase Domain 10 2 3 5
  • Mammalian Disintegrin-Metalloprotease 3 4
  • Kuzbanian Protein Homolog 3 4
  • EC 3.4.24.81 4 63
  • CDw156 3 4
  • MADM 3 4
  • Kuz 3 4
  • A Disintegrin And Metalloproteinase Domain 10 2
  • A Disintegrin And Metalloprotease Domain 10 3
  • CD156c Antigen 4
  • EC 3.4.24 63
  • HsT18717 3
  • ADAM 10 4
  • CD156c 3
  • AD10 3
  • AD18 3
  • RAK 3

External Ids for ADAM10 Gene

Previous GeneCards Identifiers for ADAM10 Gene

  • GC15M054446
  • GC15M051936
  • GC15M056466
  • GC15M056605
  • GC15M056566
  • GC15M056676
  • GC15M058887
  • GC15M035711

Summaries for ADAM10 Gene

Entrez Gene Summary for ADAM10 Gene

  • Members of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. This gene encodes and ADAM family member that cleaves many proteins including TNF-alpha and E-cadherin. Alternate splicing results in multiple transcript variants encoding different proteins that may undergo similar processing. [provided by RefSeq, Feb 2016]

GeneCards Summary for ADAM10 Gene

ADAM10 (ADAM Metallopeptidase Domain 10) is a Protein Coding gene. Diseases associated with ADAM10 include reticulate acropigmentation of kitamura and alzheimer disease 18. Among its related pathways are Degradation of the extracellular matrix and Signaling by GPCR. GO annotations related to this gene include protein homodimerization activity and receptor binding. An important paralog of this gene is ADAM17.

UniProtKB/Swiss-Prot for ADAM10 Gene

  • Cleaves the membrane-bound precursor of TNF-alpha at 76-Ala- -Val-77 to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis. Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form. Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B. May regulate the EFNA5-EPHA3 signaling.

Gene Wiki entry for ADAM10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAM10 Gene

Genomics for ADAM10 Gene

Regulatory Elements for ADAM10 Gene

Promoters for ADAM10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ADAM10 on UCSC Golden Path with GeneCards custom track

Genomic Location for ADAM10 Gene

Chromosome:
15
Start:
58,588,807 bp from pter
End:
58,749,978 bp from pter
Size:
161,172 bases
Orientation:
Minus strand

Genomic View for ADAM10 Gene

Genes around ADAM10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADAM10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADAM10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAM10 Gene

Proteins for ADAM10 Gene

  • Protein details for ADAM10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14672-ADA10_HUMAN
    Recommended name:
    Disintegrin and metalloproteinase domain-containing protein 10
    Protein Accession:
    O14672
    Secondary Accessions:
    • B4DU28
    • Q10742
    • Q92650

    Protein attributes for ADAM10 Gene

    Size:
    748 amino acids
    Molecular mass:
    84142 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Interacts with EPHA2 (By similarity). Forms a ternary EFNA5-EPHA3-ADAM10 complex mediating EFNA5 extracellular domain shedding by ADAM10 which regulates the EFNA5-EPHA3 complex internalization and function, the cleavage occurs in trans, with ADAM10 and its substrate being on the membranes of opposing cells. Interacts with NGF in a divalent cation-dependent manner.

    Three dimensional structures from OCA and Proteopedia for ADAM10 Gene

    Alternative splice isoforms for ADAM10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADAM10 Gene

Proteomics data for ADAM10 Gene at MOPED

Post-translational modifications for ADAM10 Gene

  • The precursor is cleaved by a furin endopeptidase.
  • Ubiquitination at Lys 410 and Lys 601
  • Glycosylation at Ser 36, Thr 130, Asn 267, Asn 278, Asn 439, and Asn 551
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ADAM10 (ADAM10)

Domains & Families for ADAM10 Gene

Gene Families for ADAM10 Gene

Protein Domains for ADAM10 Gene

Graphical View of Domain Structure for InterPro Entry

O14672

UniProtKB/Swiss-Prot:

ADA10_HUMAN :
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
Domain:
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • The Cys-rich region C-terminal to the disintegrin domain functions as a substrate-recognition module, it recognizes the EFNA5-EPHA3 Complex but not the individual proteins.
  • Contains 1 disintegrin domain.
  • Contains 1 peptidase M12B domain.
genes like me logo Genes that share domains with ADAM10: view

Function for ADAM10 Gene

Molecular function for ADAM10 Gene

GENATLAS Biochemistry:
a disintegrin and metalloprotease (active) domain 10,membrane anchored,cell surface adhesion protein with a shorter alternatively spliced form,homolog to Drosophila Kuzbanian gene,expressed in articular cartilage and metaphyseal bone,involved in cell-cell and cell-matrix interactions,regulating sympathoadrenal cell fate in development and neoplasia,maybe presenting alpha secretase activity,involved in the proteolytic processing of APP
UniProtKB/Swiss-Prot CatalyticActivity:
Endopeptidase of broad specificity.
UniProtKB/Swiss-Prot Function:
Cleaves the membrane-bound precursor of TNF-alpha at 76-Ala- -Val-77 to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis. Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form. Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B. May regulate the EFNA5-EPHA3 signaling.
UniProtKB/Swiss-Prot Induction:
In osteoarthritis affected-cartilage.

Enzyme Numbers (IUBMB) for ADAM10 Gene

Gene Ontology (GO) - Molecular Function for ADAM10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding NAS 12176995
GO:0019901 protein kinase binding IEA,ISS --
genes like me logo Genes that share ontologies with ADAM10: view
genes like me logo Genes that share phenotypes with ADAM10: view

Human Phenotype Ontology for ADAM10 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for ADAM10 Gene

MGI Knock Outs for ADAM10:

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for ADAM10 Gene

Localization for ADAM10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADAM10 Gene

Cell membrane; Single-pass type I membrane protein. Endomembrane system; Single-pass type I membrane protein. Note=Is localized in the plasma membrane but is predominantly expressed in the Golgi apparatus and in released membrane vesicles derived likely from the Golgi.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADAM10 Gene COMPARTMENTS Subcellular localization image for ADAM10 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 5
golgi apparatus 5
nucleus 5
plasma membrane 5
cytoskeleton 1
cytosol 1
endosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ADAM10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,ISS --
GO:0005802 trans-Golgi network IEA --
GO:0005886 plasma membrane TAS --
GO:0005925 focal adhesion IDA 21423176
GO:0009986 cell surface IEA,IDA 12475894
genes like me logo Genes that share ontologies with ADAM10: view

Pathways & Interactions for ADAM10 Gene

genes like me logo Genes that share pathways with ADAM10: view

Gene Ontology (GO) - Biological Process for ADAM10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA,ISS --
GO:0006508 proteolysis IEA --
GO:0007173 epidermal growth factor receptor signaling pathway TAS --
GO:0007219 Notch signaling pathway IEA,TAS --
GO:0007220 Notch receptor processing TAS --
genes like me logo Genes that share ontologies with ADAM10: view

No data available for SIGNOR curated interactions for ADAM10 Gene

Drugs & Compounds for ADAM10 Gene

(8) Drugs for ADAM10 Gene - From: Novoseek, DrugBank, and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
XL784 Investigational Pharma Target 0
INCB7839 Investigational Pharma 0

(3) Additional Compounds for ADAM10 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ADAM10: view

Transcripts for ADAM10 Gene

Unigene Clusters for ADAM10 Gene

ADAM metallopeptidase domain 10:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADAM10 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^
SP1: - - - - -
SP2:
SP3:
SP4: - - - - - - - - - - - - - - - - - - - -
SP5:
SP6:
SP7: - - - - - - - - - - - - - - - - - - - - - -

ExUns: 21a · 21b · 21c · 21d · 21e
SP1:
SP2:
SP3:
SP4: -
SP5:
SP6:
SP7: -

Relevant External Links for ADAM10 Gene

GeneLoc Exon Structure for
ADAM10
ECgene alternative splicing isoforms for
ADAM10

Expression for ADAM10 Gene

mRNA expression in normal human tissues for ADAM10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ADAM10 Gene

This gene is overexpressed in Nasal epithelium (18.7), Peripheral blood mononuclear cells (9.8), and Platelet (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for ADAM10 Gene



SOURCE GeneReport for Unigene cluster for ADAM10 Gene Hs.578508

mRNA Expression by UniProt/SwissProt for ADAM10 Gene

O14672-ADA10_HUMAN
Tissue specificity: Expressed in spleen, lymph node, thymus, peripheral blood leukocyte, bone marrow, cartilage, chondrocytes and fetal liver.
genes like me logo Genes that share expression patterns with ADAM10: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for ADAM10 Gene

Orthologs for ADAM10 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADAM10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ADAM10 35
  • 93.89 (n)
  • 96.61 (a)
ADAM10 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADAM10 35
  • 93.8 (n)
  • 95.68 (a)
ADAM10 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adam10 35
  • 91.14 (n)
  • 96.34 (a)
Adam10 16
Adam10 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ADAM10 35
  • 99.87 (n)
  • 100 (a)
ADAM10 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adam10 35
  • 91.27 (n)
  • 96.47 (a)
oppossum
(Monodelphis domestica)
Mammalia ADAM10 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ADAM10 36
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves ADAM10 35
  • 83.61 (n)
  • 90.22 (a)
ADAM10 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADAM10 36
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia adam10 35
  • 75.71 (n)
  • 83.18 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.7065 35
zebrafish
(Danio rerio)
Actinopterygii adam10a 35
  • 70.92 (n)
  • 77.37 (a)
zgc64203 35
adam10a 36
  • 75 (a)
OneToMany
adam10b 36
  • 72 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG1964 37
  • 49 (a)
kuz 37
  • 41 (a)
Kul 36
  • 20 (a)
OneToMany
kuz 36
  • 25 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003070 35
  • 49.08 (n)
  • 46.93 (a)
worm
(Caenorhabditis elegans)
Secernentea sup-17 37
  • 38 (a)
sup-17 36
  • 30 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 48 (a)
OneToOne
Species with no ortholog for ADAM10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADAM10 Gene

ENSEMBL:
Gene Tree for ADAM10 (if available)
TreeFam:
Gene Tree for ADAM10 (if available)

Paralogs for ADAM10 Gene

Paralogs for ADAM10 Gene

genes like me logo Genes that share paralogs with ADAM10: view

Variants for ADAM10 Gene

Sequence variations from dbSNP and Humsavar for ADAM10 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
VAR_066309 A cutaneous metastatic melanoma sample
VAR_070907 Reticulate acropigmentation of Kitamura (RAK)
VAR_070908 Alzheimer disease 18 (AD18)
VAR_070909 Alzheimer disease 18 (AD18)
VAR_070910 Reticulate acropigmentation of Kitamura (RAK)

Structural Variations from Database of Genomic Variants (DGV) for ADAM10 Gene

Variant ID Type Subtype PubMed ID
nsv7266 OTHER Inversion 18451855
nsv904254 CNV Gain 21882294
nsv1551 CNV Loss 18451855
nsv904269 CNV Loss 21882294
esv2561717 CNV Deletion 19546169
esv2129733 CNV Deletion 18987734
esv2749743 CNV Deletion 23290073
esv4784 CNV Deletion 18987735
esv2675977 CNV Deletion 23128226
esv1010091 CNV Deletion 20482838
esv5828 CNV Loss 19470904
esv1712574 CNV Deletion 17803354
esv34110 CNV Loss 18971310
nsv518097 CNV Loss 19592680

Variation tolerance for ADAM10 Gene

Residual Variation Intolerance Score: 19.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.18; 23.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADAM10 Gene

HapMap Linkage Disequilibrium report
ADAM10
Human Gene Mutation Database (HGMD)
ADAM10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADAM10 Gene

Disorders for ADAM10 Gene

MalaCards: The human disease database

(9) MalaCards diseases for ADAM10 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
reticulate acropigmentation of kitamura
  • rapk
alzheimer disease 18
  • alzheimer disease 18 late-onset
dowling-degos disease
  • reticulate acropigmentation of kitamura
alzheimer disease
  • alzheimer disease, late-onset
prion disease
  • prion disease pathway
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

ADA10_HUMAN
  • Alzheimer disease 18 (AD18) [MIM:615590]: A late-onset form of Alzheimer disease, a neurodegenerative disorder characterized by progressive dementia, loss of cognitive abilities, and deposition of fibrillar amyloid proteins as intraneuronal neurofibrillary tangles, extracellular amyloid plaques and vascular amyloid deposits. The major constituent of these plaques is the neurotoxic amyloid-beta-APP 40-42 peptide (s), derived proteolytically from the transmembrane precursor protein APP by sequential secretase processing. The cytotoxic C-terminal fragments (CTFs) and the caspase-cleaved products such as C31 derived from APP, are also implicated in neuronal death. {ECO:0000269 PubMed:19608551}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
  • Reticulate acropigmentation of Kitamura (RAK) [MIM:615537]: A rare cutaneous pigmentation disorder characterized by reticulate, slightly depressed, sharply demarcated brown macules without hypopigmentation, affecting the dorsa of the hands and feet and appearing in the first or second decade of life. The macules gradually darken and extend to the proximal regions of the extremities. The manifestations tend to progress until middle age, after which progression of the eruptions stops. The pigmentary augmentation is found on the flexor aspects of the wrists, neck, patella and olecranon. Other features include breaks in the epidermal ridges on the palms and fingers, palmoplantar pits, occasionally plantar keratoderma, and partial alopecia. {ECO:0000269 PubMed:23666529}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for ADAM10

Genetic Association Database (GAD)
ADAM10
Human Genome Epidemiology (HuGE) Navigator
ADAM10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADAM10
genes like me logo Genes that share disorders with ADAM10: view

No data available for Genatlas for ADAM10 Gene

Publications for ADAM10 Gene

  1. ADAM-10 protein is present in human articular cartilage primarily in the membrane-bound form and is upregulated in osteoarthritis and in response to IL-1alpha in bovine nasal cartilage. (PMID: 11511685) Chubinskaya S. … Tindal M.H. (J. Histochem. Cytochem. 2001) 3 4 23 67
  2. ADAM10 is expressed in human podocytes and found in urinary vesicles of patients with glomerular kidney diseases. (PMID: 20070888) Gutwein P. … Pfeilschifter J. (J. Biomed. Sci. 2010) 3 23
  3. Upregulation of the alpha-secretase ADAM10--risk or reason for hope? (PMID: 20136654) Endres K. … Fahrenholz F. (FEBS J. 2010) 3 23
  4. Expression of the anti-amyloidogenic secretase ADAM10 is suppressed by its 5'-untranslated region. (PMID: 20348102) Lammich S. … Haass C. (J. Biol. Chem. 2010) 3 23
  5. ADAM10 is upregulated in melanoma metastasis compared with primary melanoma. (PMID: 19865098) Lee S.B. … Gutwein P. (J. Invest. Dermatol. 2010) 3 23

Products for ADAM10 Gene

Sources for ADAM10 Gene

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