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ADAM10 Gene

protein-coding   GIFtS: 69

GC15M056676
ADAM metallopeptidase domain 10
(Previous name: a disintegrin and metalloproteinase domain 10 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
AD10 2
CD156c 1, 2
CDw156 3
EC 3.4.24.81 3
HsT18717 1, 2
KUZ 3
MADM 1, 2, 3, 5
kuz 1, 2
kuzbanian 2
Descriptions
ADAM 10 3
ADAM metallopeptidase domain 10 2
CD156c antigen 3
Kuzbanian protein homolog 3
Mammalian disintegrin-metalloprotease 3
a disintegrin and metalloprotease domain 10 2
a disintegrin and metalloproteinase domain 10 1, 2
External Ids
HGNC: 1881
Entrez Gene: 1022
UniProtKB: O146723
Ensembl: ENSG000001378457
Search outside databases for aliases for ADAM10 gene

Previous GC identifers: GC15M054446 GC15M051936 GC15M056466 GC15M056605 GC15M056566

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ADAM10:
Members of the ADAM family are cell surface proteins with a unique structure possessing both
potential adhesion and protease domains. This gene encodes and ADAM family member that cleaves
many proteins including TNF-alpha and E-cadherin. [provided by RefSeq]

UniProtKB/Swiss-Prot: ADA10_HUMAN, O14672
Function: Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala- -Val-77' to its mature
soluble form. Responsible for the proteolytic release of several other cell-surface proteins,
including heparin-binding epidermal growth-like factor, ephrin-A2 and for constitutive and
regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal
cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at
the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity.
Controls also the proteolytic processing of Notch and mediates lateral inhibition during
neurogenesis (By similarity)

Gene Wiki entry for ADAM10

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the ADAM10 gene  

Entrez Gene cytogenetic band: 15q2|15q22   Ensembl cytogenetic band:  15q22.1   HGNC cytogenetic band: 15q2

ADAM10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M056676:     (about GC identifiers)

Start:
56,675,802 bp from pter
End:
56,829,469 bp from pter
Size:
153,668 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000015.8  NT_010194.16  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ADA10_HUMAN, O14672 (See protein sequence)
Recommended Name: Disintegrin and metalloproteinase domain-containing protein 10 precursor  
Size: 748 amino acids; 84142 Da
Cofactor: Binds 1 zinc ion (By similarity)
Subunit: Interacts with ephrin-A2 (By similarity)
Subcellular location: Cell membrane; Single-pass type I membrane protein. Endomembrane system;
Single-pass type I membrane protein. Note=Is localized in the plasma membrane but is predominantly
expressed in the Golgi apparatus and in released membrane vesicles derived likely from the Golgi
PDB structures from and Proteopedia :
1M1I (3D)    
Secondary accessions: Q10742 Q92650

Post-translational modifications:

  • The precursor is cleaved by a furin endopeptidase (By similarity)1


  • REFSEQ proteins: NP_001101.1  

    ENSEMBL proteins: 
    ENSP00000379444 ENSP00000379440 ENSP00000386056 ENSP00000260408 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Millipore Purified and/or Recombinant ADAM10 Protein
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    R&D Systems Recombinant & Natural Proteins for ADAM10
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (ADAM10)
    Human Recombinant Proteins from Abnova (ADAM10)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    5/9 Gene Ontology (GO) cellular component terms (links to tree view) (see all 9 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus ISS--
    GO:0005737 cytoplasm ISS--
    GO:0005794 Golgi apparatus IDA12475894
    GO:0005798 Golgi-associated vesicle IDA12475894
    GO:0005886 plasma membrane IEA--
    About this table

    Antibodies for ADAM10: 
    Browse Antibodies Central at Invitrogen
    Millipore Mono- and Polyclonal Antibodies for the study of ADAM10
    Sigma-Aldrich Antibodies for ADAM10
    R&D Systems Antibodies for ADAM10
    Antibodies from Abcam (ADAM10), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (ADAM10)
    Novus Biologicals Antibodies for ADAM10

    Assays for ADAM10: 
    Browse Invitrogen for biochemical assays
    Millipore Kits and Assays for the Analysis of ADAM10
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    5/6 InterPro domains/families (see all 6 ):
     IPR018358 Disintegrin_CS
     IPR001818 Pept_M10A_M12B
     IPR001762 Blood-coag_inhib_Disintegrin
     IPR001590 Peptidase_M12B
     IPR006025 Pept_M_Zn_BS


       GeneDecks  ADAM10 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry O14672

    ProtoNet protein and cluster: O14672

    1 Blocks protein family: IPB001762 Disintegrin

    UniProtKB/Swiss-Prot: ADA10_HUMAN, O14672
    Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion,
    thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the
    activation-peptide release activates the enzyme
    Similarity: Contains 1 disintegrin domain
    Similarity: Contains 1 peptidase M12B domain

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (ADAM10)
    Millipore RNAi Products for the Analysis of ADAM10 Gene knock-down
    Abnova Chimera RNAi Products for Gene knock-down (ADAM10)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001110

                  Applied Biosystems Silencer® siRNAs for ADAM10

                  Sigma-Aldrich siRNA and siRNA Panels for ADAM10  
                         Sigma-Aldrich shRNA Panels and shRNA for ADAM10  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_001110
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_001110
                                     untagged cDNA clone in CMV expression vector: NM_001110 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_001110

    UniProtKB/Swiss-Prot: ADA10_HUMAN, O14672
    Function: Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala- -Val-77' to its mature
    soluble form. Responsible for the proteolytic release of several other cell-surface proteins,
    including heparin-binding epidermal growth-like factor, ephrin-A2 and for constitutive and
    regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal
    cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at
    the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity.
    Controls also the proteolytic processing of Notch and mediates lateral inhibition during
    neurogenesis (By similarity)
    Catalytic activity: Endopeptidase of broad specificity
    Induction: In osteoarthritis affected-cartilage
    Enzyme Number (IUBMB): EC 3.4.24.81 

    Genatlas biochemistry entry for ADAM10:
    a disintegrin and metalloprotease (active) domain 10,membrane anchored,cell surface adhesion
    protein with a shorter alternatively spliced form,homolog to Drosophila Kuzbanian gene,expressed
    in articular cartilage and metaphyseal bone,involved in cell-cell and cell-matrix
    interactions,regulating sympathoadrenal cell fate in development and neoplasia,maybe presenting
    alpha secretase activity,involved in the proteolytic processing of APP

    8 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Adam10):

    craniofacialembryogenesisgrowth/sizehematopoietic system
    immune systemlethality-prenatal/perinatalnervous system

    5/8 Gene Ontology (GO) molecular function terms (links to tree view) (see all 8 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222 metalloendopeptidase activity NAS8694785
    GO:0005178 integrin binding NAS8694785
    GO:0008233 peptidase activity IEA--
    GO:0008270 zinc ion binding IEA--
    GO:0017124 SH3 domain binding IEA--
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    2 Invitrogen iPath™ Online BioAtlas - Pathways for ADAM10 (Maps provided by GeneGo):
     IL6 activation and signaling pathway
     The role of amyloid proteins in cell adhesion

       GeneDecks  ADAM10 for the pathways selected above  
    About GeneDecksing

    2 Millipore Pathways for ADAM10
     Immune response IL-6 signaling pathway
     Cell adhesion Ephrins signaling

       GeneDecks  ADAM10 for the pathways selected above  
    About GeneDecksing

    2 Sigma-Aldrich "Your Favorite Gene" Pathways for  ADAM10  (Your Favorite Gene powered by Ingenuity) 
     Ephrin Receptor Signaling
     Axonal Guidance Signaling

       GeneDecks  ADAM10 for the pathways selected above  
    About GeneDecksing

    2 Kegg Pathways  (Kegg details for ADAM10):
     hsa05010 Alzheimer's disease
     hsa05120 Epithelial cell signaling in Helicobacter pylori infection

       GeneDecks  ADAM10 for the pathways selected above  
    About GeneDecksing
     Gene Network CentralTM Interacting Genes and Proteins Network for  ADAM10 


    5/42 Interacting proteins for ADAM10 (ENSP000002604083 O146721, 2) via UniProtKB, MINT, and/or STRING (see all 42 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARP102751EBI-1536151, EBI-608057
    PDIA3P301012MINT-4301297
    DLL1ENSP000003557183STRING (score=.987)
    EGFRENSP000002754933STRING (score=.98)
    EFNA2ENSP000002153683STRING (score=.974)
    About this table

    5/15 Gene Ontology (GO) biological process terms (links to tree view) (see all 15 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001701 in utero embryonic development ISS--
    GO:0006468 protein amino acid phosphorylation ISS--
    GO:0006508 proteolysis IEA--
    GO:0007162 negative regulation of cell adhesion NAS8694785
    GO:0007219 Notch signaling pathway ISS--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Enzo Life Sciences drugs & compounds for ADAM10
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for ADAM10
    5 Novoseek chemical compound relationships for ADAM10 gene
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    hydroxamate 49.07 5 15777180 (2), 15128827 (1), 10818225 (1)
    zinc 8.03 1 15787600 (1)
    oligonucleotide 0.00 3 16309826 (1), 15182369 (1)
    cholesterol 0.00 2 12832423 (2)
    calcium 0.00 1 16687212 (1)
    About this table


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (ADAM10)
    Millipore RNAi Products for the Analysis of ADAM10 Gene knock-down
    Abnova Chimera RNAi Products for Gene knock-down (ADAM10)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001110

                  Sigma-Aldrich siRNA and siRNA Panels for ADAM10  
                         Sigma-Aldrich shRNA Panels and shRNA for ADAM10  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_001110  

    REFSEQ mRNAs for ADAM10 gene: 

    NM_001110.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_001110  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_001110
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_001110
                                     untagged cDNA clone in CMV expression vector: NM_001110 

    Additional cDNA sequence: 

    AF009615.1 AK023460.1 AK300472.1 BC055087.1 BC104659.1 BC126253.1 BC143935.1 CR621666.1 
    Z48579.1 

    16 DOTS entries:

    DT.100864836  DT.92448214  DT.86850947  DT.100764133  DT.100796140  DT.91899409  DT.95242484  DT.86849431 
    DT.100796137  DT.95242343  DT.121064546  DT.121064539  DT.406085  DT.121064534  DT.95242499  DT.121064521 

    24/279 AceView cDNA sequences (see all 279 ):

    BF001231 AA812209 AL521861 BM787941 AL708732 AU135168 AA872057 BQ425786 
    AI338976 AU136432 BE551171 AK023460 BX957073 AA737533 BE673819 BM785695 
    BF590426 CR621666 AI422442 BM832725 AW500347 AW117725 AW197000 AA234375 

    highest scoring ESTs for ADAM10:

    BX489857 BX498019 BX502202 AA062671 AA307604 AI161066 AI273896 AI669576 AI680390 AI915503 

    Unigene Cluster for ADAM10:

    ADAM metallopeptidase domain 10
    Hs.578508  [show with all ESTs]
    Unigene Representative Sequence: NM_001110


    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for ADAM10 (see all 7 )

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^
    SP1:                          -           -     -     -                 -                                                                                       
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                          -     -     -     -     -     -     -     -     -     -     -     -                 -     -     -     -     -     -     -     -   
    SP5:                                                                                                                                                            

    ExUns: 21a · 21b · 21c · 21d · 21e
    SP1:                              
    SP2:                              
    SP3:                              
    SP4:  -                           
    SP5:                              

    About this scheme

    ECgene alternative splicing isoforms for ADAM10

    4 Ensembl transcripts including schematic representations:
    ENST00000396140  ENST00000396136  ENST00000402627  ENST00000260408  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    ADAM10 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for ADAM10

    1 / 2 / 3

    9 probe-sets matching ADAM10 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    40798_s_at2, 3 U95-A 1 1.00 1.00 0.76 1.15 Z48579 0.80 0.80 0.80 1

    71826_at2, 3 U95-D 1 0.62 1.00 0.83 0.87 H99008 0.60 1.00 0.82 1

    31934_at*2, 3 U95-A 1 1.00 1.00 0.11 0.26 Z48614 0.40 1.00 0.76 1

    202604_x_at2, 3 U133-A 1 1.00 1.00 -- -- NM_001110 0.60 1.00 0.82 1

    214895_s_at2, 3 U133-A 1 1.00 1.00 -- -- AU135154 0.40 1.00 0.76 1

    202603_at*2, 3 U133-A 1 0.91 1.00 -- -- N51370 0.20 1.00 0.72 1

    202604_x_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    214895_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    202603_at*2 U133Plus2 1 0.91 1.00 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: TATTTCTTAC

    SOURCE GeneReport for Unigene cluster: Hs.578508

    Expression variation in blood from EXPOLDB for ADAM10

    UniProtKB/Swiss-Prot: ADA10_HUMAN, O14672
    Tissue specificity: Expressed in spleen, lymph node, thymus, peripheral blood leukocyte, bone
    marrow, cartilage, chondrocytes and fetal liver

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for ADAM10 gene from 5/13 species (see all 13 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    ADAM101   -- ADAM metallopeptidase domain 10 94.6(n)
    96.92(a)
    478321  XM_535496.2  XP_535496.2 
    chimpanzee
    (Pan troglodytes)
    ADAM101   -- ADAM metallopeptidase domain 10 99.87(n)
    100(a)
    746942  XM_001172405.1  XP_001172405.1 
    cow
    (Bos taurus)
    ADAM101   -- ADAM metallopeptidase domain 10 93.98(n)
    96.66(a)
    282132  NM_174496.2  NP_776921.1 
    rat
    (Rattus norvegicus)
    Adam101   -- ADAM metallopeptidase domain 10 90.63(n)
    96.36(a)
    29650  XM_217197.4  XP_217197.4 
    mouse
    (Mus musculus)
    Adam101, 5 9 (41.00 cM)5
    a disintegrin and metallopeptidase domain 101, 5 91.13(n)1
    95.99(a)1
    114871  NM_007399.21  NP_031425.11 
     AF0113795  AI6613415  (see all 20)
    About this table        Species with no ortholog for ADAM10

    ENSEMBL Gene Tree for ADAM10
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for ADAM10 gene
    ADAM172  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/746 NCBI SNPs in ADAM10 are shown (see all 746 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 241)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 15 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs6537651,2
    C,F,H,O56829304(-) TTCGAG/AGGAGG 1 -- ut51 ese3 trp37Minor allele frequency- A:0.39MN EA EU WA 958
    rs129133831,2
    A,C,F,H56831078(+) ACATCT/GCATAT 1 -- ng3115Minor allele frequency- G:0.35NA EU EA WA 1392
    rs169533891,2
    C,F,H56830920(+) CATTAA/GTAGGC 1 -- ng3111Minor allele frequency- G:0.01NA EU EA WA 980
    rs24146091,2
    A,C,H56829744(+) AAGCAG/ATAATT 1 -- ng313Minor allele frequency- A:0.00EU EA 298
    rs5140491,2
    C,F,H56829655(+) CTTAAA/CGTCAC 1 -- ng31 tfbs39Minor allele frequency- C:0.31MN EU EA WA NA 964
    --
    rs169666111,2
    F56829948(-) CAGAGAGAG/-  
            
    AGAAA
    1 -- ng31 trp32Minor allele frequency- -:0.33MN EA 356
    rs14272811,2
    A,C,F,H,O56746565(+) CCTCAC/TTGAGA 1 -- int113Minor allele frequency- T:0.44MN EU EA WA NA 1236
    rs9728011,2
    A,C,F,H,O56708490(+) ACCAAC/TATTAT 1 -- int111Minor allele frequency- T:0.38EA NA EU WA 698
    rs23054211,2
    A,C,F,H,O56690375(+) AGGACA/GGATTT 1 -- int113Minor allele frequency- N:0.00EA NA EU WA 2496
    rs13657721,2
    A,C,F,H,O56681600(+) ttcaAT/CGTATT 1 -- int17Minor allele frequency- C:0.30EU EA WA NA 558
    About this table

    HapMap Linkage Disequilibrium images for ADAM10 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 602192

    10/16 Novoseek disease relationships for ADAM10 gene (see all 16 )

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    alzheimers disease 67.15 17 19234765 (2), 19221420 (2), 17047365 (1), 12782344 (1) (see all 10)
    cognitive deficit 40.02 2 19221420 (1)
    necrosis 38.97 11 11334139 (2), 12730960 (1), 12736275 (1), 11463349 (1) (see all 10)
    down syndrome 32.43 4 19234765 (2)
    cancer 29.12 14 18289051 (3), 19408347 (2), 15739225 (1), 17355265 (1) (see all 10)
    tumors 28.11 26 18676862 (3), 18289051 (2), 11334139 (2), 14532978 (2) (see all 16)
    carcinoma renal cell 15.48 6 19070478 (2), 19190330 (1)
    colon cancer 11.53 8 17699774 (2)
    metastasis 11.25 8 17699774 (2)
    inflammation 9.74 6 18276079 (2), 15128827 (1)
    About this table

    1 PharmGKB disease relationship for ADAM10 gene
    Disease PharmGKB Relations PubMed IDs for articles supporting these relationships
    Leukemia, Lymphocytic, Acute, L1FA  GN  12086872 12730115
    About this table

    Genetic Association Database: ADAM10
    Human Genome Epidemiology Navigator: ADAM10 (3 documents)

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/178 PubMed articles for ADAM10 gene (see all 178 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 102 HGNC: 188 AceView: ADAM10 Ensembl:ENSG00000137845 euGenes: HUgn102
    ECgene: ADAM10 H-InvDB: ADAM10
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



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