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ADAM10 Gene

protein-coding GIFtS: 69

GC15M056676

ADAM metallopeptidase domain 10
(Previous name: a disintegrin and metalloproteinase domain 10 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
AD10 ^²
CD156c ^¹, ²
CDw156 ^³
EC 3.4.24.81 ^³
HsT18717 ^¹, ²
KUZ ^³
MADM ^¹, ², ³, ⁵
kuz ^¹, ²
kuzbanian ^²

Descriptions
ADAM 10 ^³
ADAM metallopeptidase domain 10 ^²
CD156c antigen ^³
Kuzbanian protein homolog ^³
Mammalian disintegrin-metalloprotease ^³
a disintegrin and metalloprotease domain 10 ^²
a disintegrin and metalloproteinase domain 10 ^¹, ²

External Ids
HGNC: 188¹
Entrez Gene: 102²
UniProtKB: O14672³
Ensembl: ENSG00000137845⁷

Search outside databases for aliases for ADAM10 gene

Previous GC identifers: GC15M054446 GC15M051936 GC15M056466 GC15M056605 GC15M056566

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ADAM10:

Members of the ADAM family are cell surface proteins with a unique structure possessing both

potential adhesion and protease domains. This gene encodes and ADAM family member that cleaves

many proteins including TNF-alpha and E-cadherin. [provided by RefSeq]

UniProtKB/Swiss-Prot: ADA10_HUMAN, O14672

Function: Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala- -Val-77' to its mature

soluble form. Responsible for the proteolytic release of several other cell-surface proteins,

including heparin-binding epidermal growth-like factor, ephrin-A2 and for constitutive and

regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal

cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at

the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity.

Controls also the proteolytic processing of Notch and mediates lateral inhibition during

neurogenesis (By similarity)

Gene Wiki entry for ADAM10

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ADAM10 gene

Entrez Gene cytogenetic band: 15q2|15q22 Ensembl cytogenetic band: 15q22.1 HGNC cytogenetic band: 15q2

ADAM10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15M056676: (about GC identifiers)

Start:	56,675,802 bp from pter
End:	56,829,469 bp from pter
Size:	153,668 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000015.8 NT_010194.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ADA10_HUMAN, O14672 (See protein sequence)

Recommended Name: Disintegrin and metalloproteinase domain-containing protein 10 precursor

Size: 748 amino acids; 84142 Da

Cofactor: Binds 1 zinc ion (By similarity)

Subunit: Interacts with ephrin-A2 (By similarity)

Subcellular location: Cell membrane; Single-pass type I membrane protein. Endomembrane system;

Single-pass type I membrane protein. Note=Is localized in the plasma membrane but is predominantly

expressed in the Golgi apparatus and in released membrane vesicles derived likely from the Golgi

PDB structures from and Proteopedia :

1M1I (3D)

Secondary accessions: Q10742 Q92650

Post-translational modifications:

The precursor is cleaved by a furin endopeptidase (By similarity)¹

REFSEQ proteins: NP_001101.1

ENSEMBL proteins:

ENSP00000379444 ENSP00000379440 ENSP00000386056 ENSP00000260408

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant ADAM10 Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for ADAM10
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (ADAM10)
	Human Recombinant Proteins from Abnova (ADAM10)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5/9 Gene Ontology (GO) cellular component terms (links to tree view) (see all 9 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	ISS	--
GO:0005737	cytoplasm	ISS	--
GO:0005794	Golgi apparatus	IDA	12475894
GO:0005798	Golgi-associated vesicle	IDA	12475894
GO:0005886	plasma membrane	IEA	--

About this table

Antibodies for ADAM10:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of ADAM10
	Sigma-Aldrich Antibodies for ADAM10
	R&D Systems Antibodies for ADAM10
	Antibodies from Abcam (ADAM10), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ADAM10)
	Novus Biologicals Antibodies for ADAM10

Assays for ADAM10:

	Browse Invitrogen for biochemical assays
	Millipore Kits and Assays for the Analysis of ADAM10
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry O14672

ProtoNet protein and cluster: O14672

1 Blocks protein family: IPB001762 Disintegrin

UniProtKB/Swiss-Prot: ADA10_HUMAN, O14672

Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion,

thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the

activation-peptide release activates the enzyme

Similarity: Contains 1 disintegrin domain

Similarity: Contains 1 peptidase M12B domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ADAM10)
		Millipore RNAi Products for the Analysis of ADAM10 Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (ADAM10)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001110

Applied Biosystems Silencer® siRNAs for ADAM10

Sigma-Aldrich siRNA and siRNA Panels for ADAM10

Sigma-Aldrich shRNA Panels and shRNA for ADAM10

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001110
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001110
untagged cDNA clone in CMV expression vector: NM_001110

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001110

UniProtKB/Swiss-Prot: ADA10_HUMAN, O14672

Function: Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala- -Val-77' to its mature

soluble form. Responsible for the proteolytic release of several other cell-surface proteins,

including heparin-binding epidermal growth-like factor, ephrin-A2 and for constitutive and

regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal

cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at

the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity.

Controls also the proteolytic processing of Notch and mediates lateral inhibition during

neurogenesis (By similarity)

Catalytic activity: Endopeptidase of broad specificity

Induction: In osteoarthritis affected-cartilage

Enzyme Number (IUBMB): EC 3.4.24.81

Genatlas biochemistry entry for ADAM10:

a disintegrin and metalloprotease (active) domain 10,membrane anchored,cell surface adhesion

protein with a shorter alternatively spliced form,homolog to Drosophila Kuzbanian gene,expressed

in articular cartilage and metaphyseal bone,involved in cell-cell and cell-matrix

interactions,regulating sympathoadrenal cell fate in development and neoplasia,maybe presenting

alpha secretase activity,involved in the proteolytic processing of APP

8 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Adam10):

	craniofacial	embryogenesis	growth/size	hematopoietic system
immune system	lethality-prenatal/perinatal	nervous system

5/8 Gene Ontology (GO) molecular function terms (links to tree view) (see all 8 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004222	metalloendopeptidase activity	NAS	8694785
GO:0005178	integrin binding	NAS	8694785
GO:0008233	peptidase activity	IEA	--
GO:0008270	zinc ion binding	IEA	--
GO:0017124	SH3 domain binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

2 Sigma-Aldrich "Your Favorite Gene" Pathways for ADAM10 (Your Favorite Gene powered by Ingenuity)

Ephrin Receptor Signaling
Axonal Guidance Signaling

GeneDecks ADAM10 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for ADAM10

5/42 Interacting proteins for ADAM10 (ENSP00000260408³ O14672^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 42 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
AR	P10275¹	EBI-1536151, EBI-608057
PDIA3	P30101²	MINT-4301297
DLL1	ENSP00000355718³	STRING (score=.987)
EGFR	ENSP00000275493³	STRING (score=.98)
EFNA2	ENSP00000215368³	STRING (score=.974)

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5/15 Gene Ontology (GO) biological process terms (links to tree view) (see all 15 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001701	in utero embryonic development	ISS	--
GO:0006468	protein amino acid phosphorylation	ISS	--
GO:0006508	proteolysis	IEA	--
GO:0007162	negative regulation of cell adhesion	NAS	8694785
GO:0007219	Notch signaling pathway	ISS	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for ADAM10

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ADAM10
5 Novoseek chemical compound relationships for ADAM10 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
hydroxamate	49.07	5	15777180 (2), 15128827 (1), 10818225 (1)
zinc	8.03	1	15787600 (1)
oligonucleotide	0.00	3	16309826 (1), 15182369 (1)
cholesterol	0.00	2	12832423 (2)
calcium	0.00	1	16687212 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ADAM10)
		Millipore RNAi Products for the Analysis of ADAM10 Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (ADAM10)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001110

Sigma-Aldrich siRNA and siRNA Panels for ADAM10

Sigma-Aldrich shRNA Panels and shRNA for ADAM10

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001110

REFSEQ mRNAs for ADAM10 gene:

NM_001110.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001110

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001110
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001110
                                 untagged cDNA clone in CMV expression vector: NM_001110

Additional cDNA sequence:

AF009615.1 AK023460.1 AK300472.1 BC055087.1 BC104659.1 BC126253.1 BC143935.1 CR621666.1

Z48579.1

16 DOTS entries:

DT.100864836 DT.92448214 DT.86850947 DT.100764133 DT.100796140 DT.91899409 DT.95242484 DT.86849431

DT.100796137 DT.95242343 DT.121064546 DT.121064539 DT.406085 DT.121064534 DT.95242499 DT.121064521

24/279 AceView cDNA sequences (see all 279 ):

BF001231 AA812209 AL521861 BM787941 AL708732 AU135168 AA872057 BQ425786

AI338976 AU136432 BE551171 AK023460 BX957073 AA737533 BE673819 BM785695

BF590426 CR621666 AI422442 BM832725 AW500347 AW117725 AW197000 AA234375

highest scoring ESTs for ADAM10:

BX489857 BX498019 BX502202 AA062671 AA307604 AI161066 AI273896 AI669576 AI680390 AI915503

Unigene Cluster for ADAM10:

ADAM metallopeptidase domain 10

Hs.578508 [show with all ESTs]

Unigene Representative Sequence: NM_001110

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for ADAM10 (see all 7 )

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13a	·	13b	^	14a	·	14b	^	15	^	16a	·	16b	^	17	^	18	^	19	^	20	^
SP1:									-				-		-		-						-
SP2:
SP3:
SP4:									-		-		-		-		-		-		-		-		-		-		-		-						-		-		-		-		-		-		-		-
SP5:

ExUns:	21a	·	21b	·	21c	·	21d	·	21e
SP1:
SP2:
SP3:
SP4:	-
SP5:

About this scheme

ECgene alternative splicing isoforms for ADAM10

4 Ensembl transcripts including schematic representations:

ENST00000396140 ENST00000396136 ENST00000402627 ENST00000260408

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ADAM10 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ADAM10

¹ / ² / ³

9 probe-sets matching ADAM10 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
40798_s_at²^{, 3}	U95-A	1	1.00	1.00	0.76	1.15	Z48579	0.80	0.80	0.80	1
71826_at²^{, 3}	U95-D	1	0.62	1.00	0.83	0.87	H99008	0.60	1.00	0.82	1
31934_at*²^{, 3}	U95-A	1	1.00	1.00	0.11	0.26	Z48614	0.40	1.00	0.76	1
202604_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_001110	0.60	1.00	0.82	1
214895_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AU135154	0.40	1.00	0.76	1
202603_at*²^{, 3}	U133-A	1	0.91	1.00	--	--	N51370	0.20	1.00	0.72	1
202604_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
214895_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
202603_at*²	U133Plus2	1	0.91	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TATTTCTTAC

SOURCE GeneReport for Unigene cluster: Hs.578508
Expression variation in blood from EXPOLDB for ADAM10
UniProtKB/Swiss-Prot: ADA10_HUMAN, O14672
Tissue specificity: Expressed in spleen, lymph node, thymus, peripheral blood leukocyte, bone
marrow, cartilage, chondrocytes and fetal liver

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ADAM10 gene from 5/13 species (see all 13 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ADAM10¹	--	ADAM metallopeptidase domain 10	94.6(n) 96.92(a)	478321 XM_535496.2 XP_535496.2
chimpanzee (Pan troglodytes)	ADAM10¹	--	ADAM metallopeptidase domain 10	99.87(n) 100(a)	746942 XM_001172405.1 XP_001172405.1
cow (Bos taurus)	ADAM10¹	--	ADAM metallopeptidase domain 10	93.98(n) 96.66(a)	282132 NM_174496.2 NP_776921.1
rat (Rattus norvegicus)	Adam10¹	--	ADAM metallopeptidase domain 10	90.63(n) 96.36(a)	29650 XM_217197.4 XP_217197.4
mouse (Mus musculus)	Adam10^{1, 5}	9 (41.00 cM)⁵	a disintegrin and metallopeptidase domain 10^{1, 5}	91.13(n)¹ 95.99(a)¹	11487¹ NM_007399.2¹ NP_031425.1¹ AF011379⁵ AI661341⁵ (see all 20)

About this table Species with no ortholog for ADAM10

ENSEMBL Gene Tree for ADAM10

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ADAM10 gene

ADAM17²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/746 NCBI SNPs in ADAM10 are shown (see all 746 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 241)

AB	SNP ID	Valid	Chr 15 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs653765^1,2	C,F,H,O	56829304(-)	`TTCGAG/AGGAGG`	1	--	ut5¹ ese³ trp³		7	MN EA EU WA	958
	rs12913383^1,2	A,C,F,H	56831078(+)	`ACATCT/GCATAT`	1	--	ng3¹		15	NA EU EA WA	1392
	rs16953389^1,2	C,F,H	56830920(+)	`CATTAA/GTAGGC`	1	--	ng3¹		11	NA EU EA WA	980
	rs2414609^1,2	A,C,H	56829744(+)	`AAGCAG/ATAATT`	1	--	ng3¹		3	EU EA	298
	rs514049^1,2	C,F,H	56829655(+)	`CTTAAA/CGTCAC`	1	--	ng3¹ tfbs³		9	MN EU EA WA NA	964
--	rs16966611^1,2	F	56829948(-)	`CAGAGAGAG/- AGAAA`	1	--	ng3¹ trp³		2	MN EA	356
	rs1427281^1,2	A,C,F,H,O	56746565(+)	`CCTCAC/TTGAGA`	1	--	int¹		13	MN EU EA WA NA	1236
	rs972801^1,2	A,C,F,H,O	56708490(+)	`ACCAAC/TATTAT`	1	--	int¹		11	EA NA EU WA	698
	rs2305421^1,2	A,C,F,H,O	56690375(+)	`AGGACA/GGATTT`	1	--	int¹		13	EA NA EU WA	2496
	rs1365772^1,2	A,C,F,H,O	56681600(+)	`ttcaAT/CGTATT`	1	--	int¹		7	EU EA WA NA	558

About this table

HapMap Linkage Disequilibrium images for ADAM10 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 602192

10/16 Novoseek disease relationships for ADAM10 gene (see all 16 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
alzheimers disease	67.15	17	19234765 (2), 19221420 (2), 17047365 (1), 12782344 (1) (see all 10)
cognitive deficit	40.02	2	19221420 (1)
necrosis	38.97	11	11334139 (2), 12730960 (1), 12736275 (1), 11463349 (1) (see all 10)
down syndrome	32.43	4	19234765 (2)
cancer	29.12	14	18289051 (3), 19408347 (2), 15739225 (1), 17355265 (1) (see all 10)
tumors	28.11	26	18676862 (3), 18289051 (2), 11334139 (2), 14532978 (2) (see all 16)
carcinoma renal cell	15.48	6	19070478 (2), 19190330 (1)
colon cancer	11.53	8	17699774 (2)
metastasis	11.25	8	17699774 (2)
inflammation	9.74	6	18276079 (2), 15128827 (1)

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1 PharmGKB disease relationship for ADAM10 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1	FA GN	12086872 12730115

About this table

Genetic Association Database: ADAM10
Human Genome Epidemiology Navigator: ADAM10 (3 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/178 PubMed articles for ADAM10 gene (see all 178 ):

ADAM-10 protein is present in human articular cartilage primarily in the membrane-bound form and is upregulated in osteoarthritis and in response to IL-1alpha in bovine nasal cartilage. (PubMed id 11511685)^{1, 3, 4} Chubinskaya S.... Tindal M.H. (2001)
Molecular cloning of MADM: a catalytically active mammalian disintegrin-metalloprotease expressed in various cell types. (PubMed id 8694785)^{1, 3, 4} Howard L.... Glynn P. (1996)
Variation at the ADAM10 gene locus is not associated with Creutzfeldt-Jakob disease. (PubMed id 12782344)^{1, 3, 6} Plamont M.A....Laplanche J.L. (2003)
Platelet-activating factor receptor and ADAM10 mediate responses to Staphylococcus aureus in epithelial cells. (PubMed id 11786905)^{1, 3, 4} Lemjabbar H. and Basbaum C. (2002)
Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach. (PubMed id 16263699)^{3, 4} Lewandrowski U.... Sickmann A. (2006)
ADAM10-mediated cleavage of L1 adhesion molecule at the cell surface and in released membrane vesicles. (PubMed id 12475894)^{3, 4} Gutwein P.... Altevogt P. (2003)
The disintegrins ADAM10 and TACE contribute to the constitutive and phorbol ester-regulated normal cleavage of the cellular prion protein. (PubMed id 11477090)^{3, 4} Vincent B.... Checler F. (2001)
Expression of members of a novel membrane linked metalloproteinase family (ADAM) in human articular chondrocytes. (PubMed id 9016778)^{3, 4} McKie N.... Croucher P.I. (1997)
Identification and characterization of a pro-tumor necrosis factor- alpha-processing enzyme from the ADAM family of zinc metalloproteases. (PubMed id 9305925)^{3, 4} Rosendahl M.S.... Lichenstein H.S. (1997)
Radiation hybrid mapping of human ADAM10 gene to chromosome 15. (PubMed id 9344679)^{2, 3} Yamazaki K....Tanaka I. (1997)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 102	HGNC: 188	AceView: ADAM10	Ensembl:ENSG00000137845	euGenes: HUgn102
ECgene: ADAM10	H-InvDB: ADAM10

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for ADAM10
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ADAM10:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ADAM10-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ADAM10		Antibodies for ADAM10
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ADAM10		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (ADAM10)
	Antibodies (ADAM10)
	Chimera RNAi (ADAM10)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (ADAM10)
	Antibodies (ADAM10)

Search OriGene for ADAM10

Search Tocris compounds for ADAM10

	Drugs for ADAM10
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for ADAM10

GeneCards Homepage - Last full update: 1 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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ADAM10 Gene at Home site.
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ADAM10 Gene

protein-coding GIFtS: 69

Aliases &
Descriptions
for ADAM10

Summaries
for ADAM10

Genomic Location
for ADAM10

Proteins
for ADAM10

Protein Domains/
Families
for ADAM10

Gene Function
for ADAM10

Pathways & Interactions
for ADAM10

Drugs & Compounds
for ADAM10

Transcripts
for ADAM10

Expression
for ADAM10

Orthologs
for ADAM10

Paralogs
for ADAM10

SNPs/Variants
for ADAM10

Disorders & Mutations
for ADAM10

Medical News
for ADAM10

Publications
for ADAM10

Search for ADAM10

Genome Databases showing ADAM10

Other Databases showing ADAM10

Specialized Databases showing ADAM10

Licensable Technologies
for ADAM10

Services
for ADAM10

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ADAM10 Gene

protein-coding GIFtS: 69

Aliases & Descriptionsfor ADAM10

Summariesfor ADAM10

Genomic Locationfor ADAM10

Proteinsfor ADAM10

Protein Domains/Familiesfor ADAM10

Gene Functionfor ADAM10

Pathways & Interactionsfor ADAM10

Drugs & Compoundsfor ADAM10

Transcriptsfor ADAM10

Expression for ADAM10

Orthologsfor ADAM10

Paralogsfor ADAM10

SNPs/Variantsfor ADAM10

Disorders & Mutationsfor ADAM10

Medical Newsfor ADAM10

Publicationsfor ADAM10

Search for ADAM10

Genome Databases showing ADAM10

Other Databases showing ADAM10

Specialized Databases showing ADAM10

Licensable Technologiesfor ADAM10

Servicesfor ADAM10

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ADAM10

Summaries
for ADAM10

Genomic Location
for ADAM10

Proteins
for ADAM10

Protein Domains/
Families
for ADAM10

Gene Function
for ADAM10

Pathways & Interactions
for ADAM10

Drugs & Compounds
for ADAM10

Transcripts
for ADAM10

Expression
for ADAM10

Orthologs
for ADAM10

Paralogs
for ADAM10

SNPs/Variants
for ADAM10

Disorders & Mutations
for ADAM10

Medical News
for ADAM10

Publications
for ADAM10

Licensable Technologies
for ADAM10

Services
for ADAM10