ADAM10 Gene
protein-coding GIFtS : 72 GCID: GC15 M058887
ADAM metallopeptidase domain 10 a disintegrin and metalloproteinase domain 10 )
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Aliasesfor ADAM10 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases ADAM Metallopeptidase Domain 10 1 2 ADAM 102 3 MADM1 2 3 5 EC 3.4.24.813 8 CD156c1 2 AD102 HsT187171 2 A Disintegrin And Metalloprotease Domain 102 A Disintegrin And Metalloproteinase Domain 101 2 Disintegrin And Metalloproteinase Domain-Containing Protein 102 Kuz1 KUZ3 Kuzbanian Protein Homolog2 3 CD156c Antigen3 Mammalian Disintegrin-Metalloprotease2 3 EC 3.4.248 CDw1562 3
Export aliases for ADAM10 gene to outside databases Previous GC identifers: GC15M054446 GC15M051936 GC15M056466 GC15M056605 GC15M056566 GC15M056676 GC15M035711
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Summariesfor ADAM10 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for ADAM10 : Members of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. This gene encodes and ADAM family member that cleaves many proteins including TNF-alpha and E-cadherin. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: ADA10_HUMAN, O14672 Function : Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala- -Val-77' to its mature soluble form.Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis. Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form. Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B. May regulate the EFNA5-EPHA3 signaling Gene Wiki entry for ADAM10
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Genomic Viewsfor ADAM10 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000015.9 NC_018926.1 NT_010194.17 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the ADAM10 gene promoter:AhR Pbx1a AP-1 ATF-2 c-Jun AP-2gamma Other transcription factors Search SABiosciences Chromatin IP Primers for ADAM10 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 15q22 Ensembl cytogenetic band: 15q21.3 HGNC cytogenetic band: 15q2 ADAM10 Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 15 GeneLoc Exon Structure
GeneLoc location for GC15M058887: view genomic region
(about GC identifiers )
Start: 58,887,403 bp from pter End:
59,042,177 bp from pter
Size: 154,775 bases Orientation:
minus strand
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Proteinsfor ADAM10 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: ADA10_HUMAN, O14672 See
protein sequence )Recommended Name: Size : 748 amino acids; 84142 DaCofactor : Binds 1 zinc ion (By similarity)Subunit : Interacts with EPHA2 (By similarity). Forms a ternary EFNA5-EPHA3-ADAM10 complex mediating EFNA5 extracellulardomain shedding by ADAM10 which regulates the EFNA5-EPHA3 complex internalization and function, the cleavage occurs in trans, with ADAM10 and its substrate being on the membranes of opposing cells
Subcellular location : Cell membrane; Single-pass type I membrane protein. Endomembrane system; Single-pass type Imembrane protein. Note=Is localized in the plasma membrane but is predominantly expressed in the Golgi apparatus and in released membrane vesicles derived likely from the Golgi
1 PDB 3D structure from :1M1I (3D) Secondary accessions : Q10742 Q92650Explore the universe of human proteins at neXtProt for ADAM10: NX_O14672 Post-translational modifications:
The precursor is cleaved by a furin endopeptidase (By similarity)1 View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_O14672 4/14 DME Specific Peptides for ADAM10 (O14672 ) (see all 14 )ADAM10 Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins: NP_001101.1 ENSEMBL proteins: ENSP00000260408 ENSP00000386056 ENSP00000452639 ENSP00000456542 ENSP00000453952 ENSP00000391930 ENSP00000452704 ENSP00000379444 Reactome Protein details: O14672 Human Recombinant Protein Products for ADAM10: Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9 ): About this table
About GeneDecksing ADAM10 Antibody Products: Assay Products for ADAM10:
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Protein
Domains /for ADAM10 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section About GeneDecksing 5 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry O14672 ProtoNet protein and cluster: O14672
1 Blocks protein family : IPB001762 UniProtKB/Swiss-Prot: ADA10_HUMAN, O14672 Domain : The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting theenzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme Domain : The Cys-rich region C-terminal to the disintegrin domain functions as a substrate-recognition module, itrecognizes the EFNA5-EPHA3 Complex but not the individual proteins (By similarity) Similarity : Contains 1 disintegrin domainSimilarity : Contains 1 peptidase M12B domain
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Functionfor ADAM10 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Molecular Function: UniProtKB/Swiss-Prot Summary: ADA10_HUMAN, O14672 Function : Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala- -Val-77' to its mature soluble form.Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis. Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form. Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B. May regulate the EFNA5-EPHA3 signaling Catalytic activity : Endopeptidase of broad specificityInduction : In osteoarthritis affected-cartilage
Genatlas biochemistry entry for ADAM10 a disintegrin and metalloprotease (active) domain 10,membrane anchored,cell surface adhesion protein with a shorter alternatively spliced form,homolog to Drosophila Kuzbanian gene,expressed in articular cartilage and metaphyseal bone,involved in cell-cell and cell-matrix interactions,regulating sympathoadrenal cell fate in development and neoplasia,maybe presenting alpha secretase activity,involved in the proteolytic processing of APP Enzyme Numbers (IUBMB): EC 3.4.24.81 1 2 EC 3.4.24 2 Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11 ): About this table
About GeneDecksing Phenotypes: 3 GenomeRNAi human phenotypes for ADAM10 :12 MGI mutant phenotypes (inferred from 7 alleles(MGI details for Adam10) :About GeneDecksing Animal Models: Adam10 tm1Psa Adam10 tm1.1Zhu Clone Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 2 )human mouse rat OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: ADAM10 (NM_001110 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ADAM10 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ADAM10
In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAM10
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Pathways & Interactionsfor ADAM10 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways - 5/18 super-pathways (see all 18 ) About this table See pathways by source Super-pathway contained gene-specific pathways 1 Signaling by NOTCH1 t(7 9)(NOTCH1:M1580_K2555) Translocation Mutant 2 NOTCH2 Activation and Transmission of Signal to the Nucleus 3 Degradation of the extracellular matrix 4 Signaling by NOTCH3 5 Cell adhesion_Ephrins signaling
Pathway sources See GeneCards unified pathways Show all pathways 2 3 2 4 5/25 (see all 25 )2 (Kegg details for ADAM10) :About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ADAM10 STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/67 Interacting proteins for ADAM10 (O14672 2 , 3 ENSP00000260408 4 via UniProtKB, MINT, STRING , and/or I2D (see all 67 )About this table Gene Ontology (GO): 5/18 biological process terms (GO ID links to tree view) (see all 18 ): About this table
About GeneDecksing
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Drugs & Compoundsfor ADAM10 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section About GeneDecksing Browse Tocris compounds for ADAM10 9 Novoseek chemical compound relationships for ADAM10 gene About this table ADAM10 / ADA10
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Transcriptsfor ADAM10 gene (Secondary structures according to
fRNAdb ,Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
Sirion Biotech ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for ADAM10 gene: NM_001110.2 Unigene Cluster for ADAM10:
ADAM metallopeptidase domain 10 Hs.578508 [show with all ESTs ] Unigene Representative Sequence: NM_001110 18 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000260408 (uc002afd.1 uc010bgc.1 uc010ugz.1 uc002afe.1 )ENST00000402627 ENST00000561288 ENST00000482945 ENST00000396136 ENST00000470269 (uc002aff.1 )ENST00000462061 ENST00000481164 ENST00000475898 ENST00000559053 ENST00000558733 ENST00000439637 ENST00000497846 ENST00000558004 ENST00000560608 ENST00000561149 ENST00000461408 ENST00000396140 Clone OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 2 )human mouse rat OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: ADAM10 (NM_001110 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ADAM10 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ADAM10
Additional cDNA sequence: AF009615.1 AK023460.1 AK300472.1 BC055087.1 BC104659.1 BC126253.1 BC143935.1 Z48579.1
17 DOTS entries : DT.100864836 DT.92448214
DT.86850947 DT.100796140 DT.100764133 DT.95242484 DT.91899409 DT.86849431 DT.100796137 DT.121064546 DT.95242343 DT.121064539 DT.121064534 DT.406085 DT.95242499 DT.121064521 DT.121064548 24/279 AceView cDNA sequences (see all 279 ):
AI452387 CD678645 AU135154 AA131556 AA749399 AI624176 BE858060 AW197000 AU136432 AI338976 BM835390 AI332654 BM787941 AA307604 AU135168 BX951309 BE219541 CB243711 AL521862 BG286626 AL047285 BM967128 AW500347 BQ423636 GeneLoc Exon Structure 5/7 Alternative Splicing Database (ASD) splice patterns (SP) for ADAM10 (see all 7 ) About this scheme ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ SP1 : - - - - - SP2 : SP3 : SP4 : - - - - - - - - - - - - - - - - - - - - SP5 :
ExUns: 21a · 21b · 21c · 21d · 21e SP1 : SP2 : SP3 : SP4 : - SP5 :
ECgene alternative splicing isoforms for ADAM10
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Expression for ADAM10 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section ADAM10 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TATTTCTTACAbout this image ADAM10 expression in embryonic tissues and stem cells About this table
3 LifeMap In Vivo Development Anatomical Compartments/CellsTissue Category (developmental path) Ovary Ovigerous Cord Ovarian Somatic Cells Ovary Eye Lens Eye Eye Retina Eye Expression: Experimental details:
In-situ hybridization
See ADAM10 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for ADAM10 SOURCE GeneReport for Unigene cluster: Hs.578508 UniProtKB/Swiss-Prot: ADA10_HUMAN, O14672 Tissue specificity : Expressed in spleen, lymph node, thymus, peripheral blood leukocyte, bone marrow, cartilage,chondrocytes and fetal liver SABiosciences Expression via Pathway-Focused PCR Arrays including ADAM10 : Primer OriGene genome-wide validated SYBR primer pairs in human mouse rat Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAM10
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Orthologsfor ADAM10 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for ADAM10 gene from 6/24 species (see all 24 ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
chicken Aves ADAM101
ADAM metallopeptidase domain 10
83.36(n) 89.83(a)
374113 NM_204261.1 NP_989592.1
lizard Reptilia ADAM106
--
86(a)
1 ↔ 1
GL343573.1(218220-235938)
African clawed frog Amphibia Xl.70652
Xenopus laevis metalloprotease/disintegrin (ADAM10) more
79.21(n)
AF508151.1
zebrafish Actinopterygii zgc642032
hypothetical protein MGC64203
72.16(n)
393392 BC054638.1
fruit fly Insecta CG19643 1
metalloendopeptidase3 1
49(a) 3 50.68(n) 1 47.66(a) 1
99B93 43501 1 NM_143459.2 1 NP_651716.1 1
worm Secernentea sup-173
Zinc-binding metalloprotease domain
38(a)
I(8801158-8804870) --
ENSEMBL Gene Tree for ADAM10 (if available)TreeFam Gene Tree for ADAM10 (if available)
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Paralogsfor ADAM10 gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for ADAM10 gene ADAM17 2 4 SIMAP similar genes for ADAM10 using alignment to 10 protein entries: ADA10_HUMAN (see all proteins ):BCL2L14 VPS18 VPS45 FBXO16 About GeneDecksing
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Genomic Variantsfor ADAM10 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 15 pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for ADAM10 (58887403 - 59042177 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 9 variations for ADAM10 3 CNVs 102111 87694 47963 6 Indels 40102 40103 61450 45352 25535 41882 Human Gene Mutation Database (HGMD) : ADAM10 SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human mouse rat
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Disorders
/ Diseasesfor ADAM10 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section About GeneDecksing OMIM gene information: 602192
OMIM disorders : --20/49 (see all 49 ): About MalaCards pre-eclampsia amyotrophic lateral sclerosis adenoid cystic carcinoma oral squamous cell carcinoma lateral sclerosis mantle cell lymphoma squamous cell carcinoma down syndrome basal cell carcinoma dilated cardiomyopathy amyloidosis adenoiditis eclampsia anoxia alzheimer's disease colon cancer multiple sclerosis melanoma metastasis osteoarthritis myopathy 1 disease from the University of Copenhagen DISEASES database for ADAM10 :Alzheimer's disease 10/16 Novoseek disease relationships for ADAM10 gene (see all 16 ) About this table
Disease
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
alzheimers disease
67.5
21
19234765 (2), 19221420 (2), 17047365 (1), 19608551 (1) (see all 13 )
necrosis
42.1
15
11334139 (2), 20136654 (1), 12730960 (1), 12736275 (1) (see all 14 )
cognitive deficit
36.3
2
19221420 (1)
tumors
32.3
29
18676862 (3), 18289051 (2), 11334139 (2), 14532978 (2) (see all 19 )
down syndrome
29.5
4
19234765 (2)
cancer
28
17
18289051 (3), 19783906 (2), 19408347 (2), 15739225 (1) (see all 12 )
inflammation
16.2
6
18276079 (2), 15128827 (1)
metastasis
13.1
13
19865098 (3), 17699774 (2)
carcinoma renal cell
11.7
6
19070478 (2), 19190330 (1)
colon cancer
7.52
8
17699774 (2)
Genetic Association Database (GAD): ADAM10 Human Genome Epidemiology (HuGE) Navigator: ADAM10 (12 documents) Export disorders for ADAM10 gene to outside databases
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Publicationsfor ADAM10 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for ADAM10 gene, integrated from 9 sources (see all 263 ):(articles sorted by number of sources associating them with ADAM10) Utopia : connect your pdf to the dynamic
ADAM-10 protein is present in human articular cartilage primarily in the membrane-bound form and is upregulated in osteoarthritis and in response to IL-1alpha in bovine nasal cartilage. (PubMed id 11511685) 1 , 2 , 9(2001) Molecular cloning of MADM: a catalytically active mammalian disintegrin-metalloprotease expressed in various cell types. (PubMed id 8694785) 1 , 2 , 9(1996) Variation at the ADAM10 gene locus is not associated with Creutzfeldt-Jakob disease. (PubMed id 12782344) 1 , 4, 9(2003) Adam meets Eph: an ADAM substrate recognition module acts as a molecular switch for ephrin cleavage in trans. (PubMed id 16239146) 1 , 2 , 9(2005) Platelet-activating factor receptor and ADAM10 mediate responses to Staphylococcus aureus in epithelial cells. (PubMed id 11786905) 1 , 2 , 9(2002) Substrate requirements for SPPL2b-dependent regulated intramembrane proteolysis. (PubMed id 19114711) 1 , 2 (2009) The Fas ligand intracellular domain is released by ADAM10 and SPPL2a cleavage in T-cells. (PubMed id 17557115) 1 , 2 (2007) Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach. (PubMed id 16263699) 1 , 2 (2006) ADAM10-mediated cleavage of L1 adhesion molecule at the cell surface and in released membrane vesicles. (PubMed id 12475894) 1 , 2 (2003) The disintegrins ADAM10 and TACE contribute to the constitutive and phorbol ester-regulated normal cleavage of the cellular prion protein. (PubMed id 11477090) 1 , 2 (2001)
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External Searches for ADAM10 gene
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Specialized Databases showing ADAM10 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description PharmGKB entry for ADAM10 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for ADAM10 gene: ADAM10 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor ADAM10 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript , LifeMap BioReagents , and Sirion Biotech , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory )About This Section
OriGene Antibodies for ADAM10 OriGene shRNA RFP for ADAM10 OriGene 29mer shRNA kits in GFP-retroviral vector in human mouse rat OriGene genome-wide validated SYBR primer pairs in human mouse rat Browse OriGene Protein Over-expression Lysates Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for ADAM10 OriGene 3'-UTR Clone for ADAM10 OriGene untagged cDNA clones in CMV expression vector in human mouse rat OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for ADAM10 OriGene Custom Protein Services for ADAM10 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ADAM10 QIAGEN SeqTarget long-range PCR primers in human mouse rat QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ADAM10
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and Proteopedia 
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Kegg Pathways 
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Expression by the Database of Embryonic development, Stem cell research, and
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Anatomical Compartment 
Negative
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