Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms of Use
- Terms of Use
- 3rd Party Notice
About Us
- GeneCards Team
- Our Publications
- Citing GeneCards
- Licensing Agreement
- Weizmann Institute
- LifeMap Sciences Inc
User Feedback
GeneCards Plus
- Premium Tools
  
  Learn more

Set Analyses:

VarElect

Advanced Search

ADAL Gene

protein-coding GIFtS: 44
GCID: GC15P043622

Adenosine Deaminase-Like

See related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

TryGeneCards Plus

Aliases
Adenosine Deaminase-Like¹ ²
Adenosine Deaminase-Like Protein²
EC 3.5.4.-³
EC 3.5.4⁸

External Ids:	HGNC: 31853¹	Entrez Gene: 161823²	Ensembl: ENSG00000168803⁷	UniProtKB: Q6DHV7³

Export aliases for ADAL gene to outside databases

Previous GC identifers: GC15P041416 GC15P020471

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for ADAL Gene:

ADAL (adenosine deaminase-like) is a protein-coding gene. Diseases associated with ADAL include hyperopia, and epididymitis. GO annotations related to this gene include adenosine deaminase activity.

UniProtKB/Swiss-Prot: ADAL_HUMAN, Q6DHV7

Function: Putative nucleoside deaminase. May catalyze the hydrolytic deamination of adenosine or some similar

substrate and play a role in purine metabolism (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus

RefSeq DNA sequence:

NC_000015.10 NT_010194.18 NC_018926.2

Regulatory elements:

Regulatory transcription factor binding sites in the ADAL gene promoter:
TBP HTF POU3F2 Evi-1 NF-AT CHOP-10 NF-AT4 NF-AT2 NF-AT3 NF-AT1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ADAL promoter sequence

Search Chromatin IP Primers for ADAL

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ADAL

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q15.3 Ensembl cytogenetic band: 15q15.3 HGNC cytogenetic band: 15q15.3

ADAL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADAL gene location

GeneLoc information about chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15P043622: view genomic region (about GC identifiers)

Start:	43,622,872 bp from pter	End:	43,646,096 bp from pter
Size:	23,225 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: ADAL_HUMAN, Q6DHV7 (See protein sequence)

Recommended Name: Adenosine deaminase-like protein

Size: 355 amino acids; 40264 Da

Cofactor: Binds 1 zinc ion per subunit (By similarity)

Secondary accessions: A6NHZ3 B4DQM8

Alternative splicing: 3 isoforms: Q6DHV7-1 Q6DHV7-2 Q6DHV7-3

Explore the universe of human proteins at neXtProt for ADAL: NX_Q6DHV7

Explore proteomics data for ADAL at MOPED

Selected DME Specific Peptides for ADAL (Q6DHV7) (see all 5)

HHFGFWY

PKVELHAHL

PDRIGHGTFL

VTKDVIKEFA

See ADAL Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts):

NP_001012987.1 NP_001152752.1

ENSEMBL proteins:

ENSP00000413074 ENSP00000374302 ENSP00000455907 ENSP00000456242 ENSP00000457591

ENSP00000398744

Reactome Protein details: Q6DHV7

ADAL Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate for ADAL OriGene Custom MassSpec OriGene Custom Protein Services for ADAL
	GenScript Custom Purified and Recombinant Proteins Services for ADAL
	Novus Biologicals ADAL Protein Novus Biologicals ADAL Lysates
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for ADAL

ADAL Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for ADAL
	Novus Biologicals ADAL Antibodies
	Abcam antibodies for ADAL
	Cloud-Clone Corp. Antibodies for ADAL
	Search ThermoFisher Antibodies for ADAL
	LSBio Antibodies in human, mouse, rat for ADAL

ADAL Assay Products:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for ADAL
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for ADAL
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for ADAL Cloud-Clone Corp. CLIAs for ADAL

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TryGeneCards Plus

1 InterPro protein domain:

IPR001365 A/AMP_deaminase_dom

Graphical View of Domain Structure for InterPro Entry Q6DHV7

ProtoNet protein and cluster: Q6DHV7

UniProtKB/Swiss-Prot: ADAL_HUMAN, Q6DHV7

Similarity: Belongs to the adenosine and AMP deaminases family

ADAL for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Molecular Function:

UniProtKB/Swiss-Prot Summary: ADAL_HUMAN, Q6DHV7

Function: Putative nucleoside deaminase. May catalyze the hydrolytic deamination of adenosine or some similar

substrate and play a role in purine metabolism (By similarity)

Enzyme Numbers (IUBMB): EC 3.5.4² EC 3.5.4.-¹

Gene Ontology (GO): 3 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004000	adenosine deaminase activity	IBA	--
GO:0019239	deaminase activity	--	--
GO:0046872	metal ion binding	IEA	--

ADAL for ontologies About GeneDecksing

Animal Models:

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ADAL

inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ADAL

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ADAL

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ADAL

miRNA Products:		Block miRNA regulation of human, mouse, rat ADAL using miScript Target Protectors
		3 qRT-PCR Assays for microRNAs that regulate ADAL:
		hsa-miR-576-5p hsa-miR-3920 hsa-miR-29a*
		SwitchGear 3'UTR luciferase reporter plasmid: ADAL 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for ADAL
		Predesigned siRNA for gene silencing in human, mouse, rat ADAL

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for ADAL

Clone Products:		OriGene clones in human, mouse for ADAL (see all 13) OriGene ORF clones in mouse, rat for ADAL OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): ADAL (NM_001012969)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADAL
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADAL

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ADAL
		Browse ESI BIO Cell Lines and PureStem Progenitors for ADAL

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAL

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
cytosol	4
nucleus	2
peroxisome	1

About this image

Gene Ontology (GO): 1 cellular component term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005829	cytosol	TAS	--

ADAL for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
About This Section

TryGeneCards Plus

SuperPaths for ADAL About

See pathways by source

SuperPath

Contained pathways About

Purine metabolism (REACTOME)

	Purine metabolism	0.42			Purine salvage	0.00
	Metabolism of nucleotides	0.42

Abacavir transport and metabolism

Abacavir transport and metabolism

Abacavir metabolism

0.00

Metabolism

Metabolism

0.38

Pathways by source See SuperPaths
Show all pathways

2 Reactome Pathways for ADAL

	Purine salvage
	Abacavir metabolism

ADAL for pathways About GeneDecksing

Custom Pathway & Disease-focused RT² Profiler PCR Arrays for ADAL
Interactions:

Search GeneGlobe Interaction Network for ADAL

Gene Ontology (GO): Selected biological process terms (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006144	purine nucleobase metabolic process	TAS	--
GO:0006154	adenosine catabolic process	IBA	--
GO:0009117	nucleotide metabolic process	IEA	--
GO:0009168	purine ribonucleoside monophosphate biosynthetic process	--	--
GO:0017144	drug metabolic process	TAS	--

ADAL for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
About This Section

TryGeneCards Plus

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for ADAL

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
About This Section

TryGeneCards Plus

REFSEQ mRNAs for ADAL gene (2 alternative transcripts):

NM_001012969.3 NM_001159280.2

Unigene Cluster for ADAL:

Adenosine deaminase-like

Hs.533913 [show with all ESTs]

Unigene Representative Sequence: NM_001159280

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000428046(uc010udo.2) ENST00000389651(uc001zrh.3) ENST00000565555

ENST00000563551 ENST00000562188 ENST00000566154 ENST00000422466(uc001zri.2)

miRNA Products:		Block miRNA regulation of human, mouse, rat ADAL using miScript Target Protectors
		3 qRT-PCR Assays for microRNAs that regulate ADAL:
		hsa-miR-576-5p hsa-miR-3920 hsa-miR-29a*
		SwitchGear 3'UTR luciferase reporter plasmid: ADAL 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for ADAL
		Predesigned siRNA for gene silencing in human, mouse, rat ADAL

Clone Products:		OriGene clones in human, mouse for ADAL (see all 13) OriGene ORF clones in mouse, rat for ADAL OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): ADAL (NM_001012969)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADAL
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADAL

Primer Products:		OriGene qPCR primer pairs and template standards for ADAL OriGene qSTAR qPCR primer pairs in human, mouse for ADAL
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat ADAL
		QuantiTect SYBR Green Assays in human, mouse, rat ADAL
		QuantiFast Probe-based Assays in human, mouse, rat ADAL

Additional mRNA sequence:

AK126583.1 AK298870.1 BC075857.1

11 DOTS entries:

DT.412202 DT.99983998 DT.99997537 DT.100683462 DT.121034813 DT.92417578 DT.100693900 DT.432612

DT.121034795 DT.95155463 DT.100705722

Selected AceView cDNA sequences (see all 94):

BX108368 BQ011595 BI789209 AA293034 BU737982 AA044810 CK903308 AI080123

BI962698 BX108001 AA227487 AA284726 BQ188219 CK903307 BQ447767 BQ012134

BC075857 AI123939 AA284902 AA293426 BM700326 AI420327 CF529844 AI654975

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TryGeneCards Plus

ADAL expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GAAAATCCCA

About this image

ADAL Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

ADAL Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.533913

Custom PCR Arrays for ADAL

Primer Products:		OriGene qPCR primer pairs and template standards for ADAL OriGene qSTAR qPCR primer pairs in human, mouse for ADAL
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat ADAL
		QuantiTect SYBR Green Assays in human, mouse, rat ADAL
		QuantiFast Probe-based Assays in human, mouse, rat ADAL

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAL

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

TryGeneCards Plus

This gene was present in the common ancestor of eukaryotes.

Orthologs for ADAL gene from Selected species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Adal^{1 , 5}	adenosine deaminase-like^{1, 5}	84.36(n)¹ 83.44(a)¹		2 (60.37 cM)⁵ 75894¹ NM_029475.1¹ NP_083751.1¹ 121140428⁵
chicken (Gallus gallus)	Aves	ADAL¹	adenosine deaminase-like	74.39(n) 74.13(a)		415391 NM_001030547.1 NP_001025718.1
lizard (Anolis carolinensis)	Reptilia	ADAL⁶	adenosine deaminase-like	59(a)	1 ↔ 1	GL343644.1(421-5565)
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.12484²	Transcribed sequence with weak similarity to protein more	72.72(n)		BX713295.1
zebrafish (Danio rerio)	Actinopterygii	adal¹	adenosine deaminase-like	62.94(n) 63.9(a)		619263 NM_001033744.1 NP_001028916.1
fruit fly (Drosophila melanogaster)	Insecta	Ada¹	Adenosine deaminase	47.4(n) 42.2(a)		41092 NM_141609.3 NP_649866.1
worm (Caenorhabditis elegans)	Secernentea	C44B7.12¹	C44B7.12	46.49(n) 34.54(a)		259441 NM_182155.4 NP_871955.2
thale cress (Arabidopsis thaliana)	eudicotyledons	AT4G04880¹	AT4G04880	50.33(n) 41.67(a)		825826 NM_116726.3 NP_192397.2
rice (Oryza sativa)	Liliopsida	Os07g0661000¹	Os07g0661000	51.54(n) 41.45(a)		4344179 NM_001067069.1 NP_001060534.1

ENSEMBL Gene Tree for ADAL (if available)
TreeFam Gene Tree for ADAL (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

TryGeneCards Plus

Paralogs for ADAL gene

ADAL for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for ADAL
PGOHUM00000242472

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

TryGeneCards Plus

SNP ID	Valid	Clinical significance	Chr 15 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs192090972^1,2		--	43625024(+)	`CTGCTC/TTAATA`	2	--	int¹		0	--	--	--	--
rs139155336^1,2		--	43625068(+)	`AGTGTG/TTGTTG`	2	--	int¹		0	--	--	--	--
rs142446983^1,2		--	43625074(+)	`TGTTGC/GCTTCC`	2	--	int¹		0	--	--	--	--
rs183133580^1,2		--	43625080(+)	`CTTCCA/GTCCCA`	2	--	int¹		0	--	--	--	--
rs78761824^1,2	C	--	43625218(+)	`CCATAG/TGTTAA`	2	--	int¹		0	--	--	--	--
rs187142092^1,2		--	43625342(+)	`TGGCCA/GGGCGC`	2	--	int¹		0	--	--	--	--
rs79099426^1,2	C	--	43625345(+)	`CCGGGC/TGCAGT`	2	--	int¹		0	--	--	--	--
rs113350536^1,2	C	--	43625346(+)	`CGGGCG/TCAGTG`	2	--	int¹		1		WA	2
rs139452344^1,2	C	--	43625356(+)	`GGCTCA/GCTCCT`	2	--	int¹		0	--	--	--	--
rs1123947^1,2	C,F	--	43625433(+)	`TGAGAT/CCCCGT`	2	--	int¹		6		NA WA CSA EA	132

HapMap Linkage Disequilibrium report for ADAL (43622872 - 43646096 bp)

Structural Variations
Database of Genomic Variants (DGV) 1 variation for ADAL: About this table

Variant ID	Type	Subtype	PubMed ID
nsv1512	CNV	Loss	18451855

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing ADAL

DNA2.0 Custom Variant and Variant Library Synthesis for ADAL

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TryGeneCards Plus

4 diseases for ADAL:
About MalaCards

hyperopia epididymitis tuberculosis malaria

1 disease from the University of Copenhagen DISEASES database for ADAL:

Epididymitis

ADAL for disorders About GeneDecksing

Export disorders for ADAL gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

TryGeneCards Plus

PubMed articles for ADAL gene integrated from 10 sources:
(articles sorted by number of sources associating them with ADAL)

Utopia: connect your pdf to the dynamic
world of online information

Mutations in adenosine deaminase-like (ADAL) protein confer resistance to the antiproliferative agents N6-cyclopropyl-PMEDAP and GS-9219. (PubMed id 23645737)¹ Frey C.R....Cihlar T. (Anticancer Res. 2013)
Adenosine deaminase-like protein 1 (ADAL1): characterization and substrate specificity in the hydrolysis of N(6)- or O(6)-substituted purine or 2-aminopurine nucleoside monophosphates. (PubMed id 21755941)¹ Murakami E....Furman P.A. (J. Med. Chem. 2011)
Analysis of the DNA sequence and duplication history of human chromosome 15. (PubMed id 16572171)² Zody M.C....Nusbaum C. (Nature 2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S.... Malek J. (Genome Res. 2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)² Ota T.... Sugano S. (Nat. Genet. 2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

TryGeneCards Plus

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

TryGeneCards Plus

Entrez Gene: 161823	HGNC: 31853	AceView: LOC161823	Ensembl:ENSG00000168803	euGenes: HUgn161823
ECgene: ADAL	H-InvDB: ADAL

(According to HUGE)
About This Section

TryGeneCards Plus

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

TryGeneCards Plus

Name	Description
PharmGKB entry for ADAL	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ADAL gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

TryGeneCards Plus

Patent Information for ADAL gene:
Search GeneIP for patents involving ADAL

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

TryGeneCards Plus


	EMD Millipore genomic analysis products

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Enzyme Activity Assays/Reagents
	Browse ELISpot/FluoroSpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Luminex Assays
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Recombinant/Natural Proteins		Browse Stem Cell Products
	Browse cDNA Clones		Browse Proteome Profiler Antibody Arrays

	Browse OriGene Antibodies		OriGene RNAi products in human, mouse, rat for ADAL
	OriGene qPCR primer pairs and template standards for ADAL		OriGene Protein Over-expression Lysate for ADAL
	OriGene Custom Mass Spec		OriGene clones in human, mouse for ADAL
	OriGene qSTAR qPCR primer pairs in human, mouse for ADAL		Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
	OriGene ORF clones in mouse, rat for ADAL		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for ADAL		OriGene Custom Protein Services for ADAL

	Block miRNA regulation of human, mouse, rat ADAL using miScript Target Protectors		SeqTarget long-range PCR primers for resequencing ADAL
	DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ADAL		Predesigned siRNA for gene silencing in human, mouse, rat ADAL
	QuantiFast Probe-based Assays in human, mouse, rat ADAL		QuantiTect SYBR Green Assays in human, mouse, rat ADAL
	Custom PCR Arrays for ADAL		Search Chromatin IP Primers for ADAL
	Pre-validated RT² qPCR Primer Assay in human, mouse, rat ADAL		Search GeneGlobe Interaction Network for ADAL
	Regulatory tfbs in ADAL promoter

	GenScript Custom Purified and Recombinant Proteins Services for ADAL		GenScript cDNA clones with any tag delivered in your preferred vector for ADAL
	GenScript Custom Assay Services for ADAL		GenScript Custom overexpressing Cell Line Services for ADAL
	CloneReady with Over 120,000 Genes		Gene Synthesis: Any Gene in Any Vector
	Vector-based siRNA and miRNA, Ready for Transfection		Gene Mutant Library, Variants up to 10^11
	Plasmid Preparation		Custom Peptide Services

Search for Antibodies & Assays

Search Tocris compounds for ADAL

	Browse Sino Biological Proteins
	Browse Sino Biological Cell Lysates
	Browse Sino Biological cDNA Clones
	4000+ Proteins
	Search Sino Biological for antibodies, proteins & pathways
	Protein Production Services
	Transfection Reagents
	Protein A/G/L resins
	Isotyping reagents

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	ADAL antibodies
	ADAL proteins
	ADAL lysates

	Antibodies for ADAL
	See all of Abcam's Antibodies, Kits and Proteins for ADAL
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

	Proteins for ADAL
	Antibodies for ADAL
	ELISAs for ADAL
	CLIAs for ADAL

Browse ESI BIO Cell Lines and PureStem Progenitors for ADAL

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAL

	SwitchGear 3'UTR luciferase reporter plasmids for ADAL
	SwitchGear Promoter luciferase reporter plasmids for ADAL

Search ThermoFisher Antibodies for ADAL

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADAL

	inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ADAL
	inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ADAL

LSBio Antibodies in human, mouse, rat for ADAL

Customized transgenic rodents for:

	Humanization
	Biomarker expression
	Off-target effect monitoring
	Translational medicine
	Tissue-specific gene expresssion
	Time-controlled gene expresssion

Browse compounds at ApexBio

GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

View Random Gene

Category			(GIFtS: )
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes ADAL gene at Home site.

Version: 3.12.142 28 July 2014
hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4

GeneCards Plus

Advanced Search

Export list of displayed genes

ADAL Gene

Adenosine Deaminase-Like

Aliases
for ADAL gene

Summaries
for ADAL gene

Genomic Views
for ADAL gene

Proteins
for ADAL gene

ADAL Human Recombinant Protein Products:

ADAL Antibody Products:

ADAL Assay Products:

Domains /
Families
for ADAL gene

Function
for ADAL gene

Localization
for ADAL gene

Pathways & Interactions
for ADAL gene

Drugs & Compounds
for ADAL gene

Transcripts
for ADAL gene

Expression
for ADAL gene

Orthologs
for ADAL gene

Paralogs
for ADAL gene

Genomic Variants
for ADAL gene

Disorders / Diseases
for ADAL gene

Publications
for ADAL gene

External Searches for ADAL gene

Genome Databases showing ADAL gene

Other Databases showing ADAL gene

Specialized Databases showing ADAL gene

Intellectual Property
for ADAL gene

Products
for ADAL gene

View Random Gene

GeneCards Plus

Advanced Search

Export list of displayed genes

ADAL Gene

Adenosine Deaminase-Like

Aliasesfor ADAL gene

Summariesfor ADAL gene

Genomic Viewsfor ADAL gene

Proteinsfor ADAL gene

ADAL Human Recombinant Protein Products:

ADAL Antibody Products:

ADAL Assay Products:

Domains /Familiesfor ADAL gene

Functionfor ADAL gene

Localizationfor ADAL gene

Pathways & Interactionsfor ADAL gene

Drugs & Compoundsfor ADAL gene

Transcriptsfor ADAL gene

Expression for ADAL gene

Orthologsfor ADAL gene

Paralogsfor ADAL gene

Genomic Variantsfor ADAL gene

Disorders / Diseasesfor ADAL gene

Publicationsfor ADAL gene

External Searches for ADAL gene

Genome Databases showing ADAL gene

Other Databases showing ADAL gene

Specialized Databases showing ADAL gene

Intellectual Propertyfor ADAL gene

Productsfor ADAL gene

View Random Gene

Aliases
for ADAL gene

Summaries
for ADAL gene

Genomic Views
for ADAL gene

Proteins
for ADAL gene

Domains /
Families
for ADAL gene

Function
for ADAL gene

Localization
for ADAL gene

Pathways & Interactions
for ADAL gene

Drugs & Compounds
for ADAL gene

Transcripts
for ADAL gene

Expression
for ADAL gene

Orthologs
for ADAL gene

Paralogs
for ADAL gene

Genomic Variants
for ADAL gene

Disorders / Diseases
for ADAL gene

Publications
for ADAL gene

Intellectual Property
for ADAL gene

Products
for ADAL gene