Aliases for ADAL Gene
External Ids for ADAL Gene
- HGNC: 31853
- Entrez Gene: 161823
- Ensembl: ENSG00000168803
- UniProtKB: Q6DHV7
Previous GeneCards Identifiers for ADAL Gene
- GC15P041416
- GC15P043622
- GC15P020471
Summaries for ADAL Gene
GeneCards Summary for ADAL Gene
ADAL (Adenosine Deaminase Like) is a Protein Coding gene. Among its related pathways are Metabolism and Abacavir transport and metabolism. Gene Ontology (GO) annotations related to this gene include adenosine deaminase activity and deaminase activity.
UniProtKB/Swiss-Prot for ADAL Gene
-
Putative nucleoside deaminase. May catalyze the hydrolytic deamination of adenosine or some similar substrate and play a role in purine metabolism (By similarity).
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAL Gene
Genomics for ADAL Gene
GeneHancer (GH) Regulatory Elements for ADAL Gene
Regulatory Element Products
Genomic Locations for ADAL Gene
- chr15:43,330,356-43,354,555
- (GRCh38/hg38)
- Size:
- 24,200 bases
- Orientation:
- Plus strand
- chr15:43,622,872-43,646,096
- (GRCh37/hg19)
Genomic View for ADAL Gene
- Cytogenetic band:
-
- 15q15.3 by Ensembl
- 15q15.3 by Entrez Gene
- 15q15.3 by HGNC


RefSeq DNA sequence for ADAL Gene
Proteins for ADAL Gene
-
Protein details for ADAL Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q6DHV7-ADAL_HUMAN
- Recommended name:
- Adenosine deaminase-like protein
- Protein Accession:
- Q6DHV7
- A6NHZ3
- B4DQM8
Protein attributes for ADAL Gene
- Size:
- 355 amino acids
- Molecular mass:
- 40264 Da
- Cofactor:
- Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Quaternary structure:
- No Data Available
Protein Expression for ADAL Gene
Selected DME Specific Peptides for ADAL Gene
- Q6DHV7:
-
- PDRIGHGTFL
- PKVELHAHL
- VTKDVIKEFA
- DGVKYLELRSTPR
- HHFGFWY
Post-translational modifications for ADAL Gene
Other Protein References for ADAL Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for ADAL
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Protein Products
-
OriGene Purified Proteins for ADAL
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Assay Products
Domains & Families for ADAL Gene
Gene Families for ADAL Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for ADAL Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for ADAL Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q6DHV7UniProtKB/Swiss-Prot:
ADAL_HUMAN :- Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.
- Family:
-
- Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.
Function for ADAL Gene
Molecular function for ADAL Gene
- UniProtKB/Swiss-Prot Function:
- Putative nucleoside deaminase. May catalyze the hydrolytic deamination of adenosine or some similar substrate and play a role in purine metabolism (By similarity).
Enzyme Numbers (IUBMB) for ADAL Gene
Phenotypes From GWAS Catalog for ADAL Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004000 | adenosine deaminase activity | IBA | -- |
GO:0016787 | hydrolase activity | IEA | -- |
GO:0019239 | deaminase activity | IEA | -- |
GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for ADAL Gene
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-
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-
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CRISPR Products
-
OriGene CRISPR knockouts for ADAL
- genomics-online: gRNA clones - Search results for 74 available ADAL gene related products
- Overview of 74 available ADAL gene related products
- Applied Biological Materials CRISPR for ADAL
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ADAL
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miRNA Products
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Inhibitory RNA Products
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- Overview of 74 available ADAL gene related products
-
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Clone Products
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-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for ADAL
-
ViGene Biosciences adenoviral particle packaged cDNA for ADAL gene
-
ViGene Biosciences lentiviral particle packaged cDNA for ADAL gene
-
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No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ADAL Gene
Localization for ADAL Gene
- Microtubules (2)
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005829 | cytosol | TAS | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for ADAL Gene
Pathways & Interactions for ADAL Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Purine metabolism |
.01
|
|
2 | Abacavir transport and metabolism | ||
3 | Metabolism |
.37
|
Pathways by source for ADAL Gene
6 Reactome pathways for ADAL Gene
Interacting Proteins for ADAL Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006154 | adenosine catabolic process | IBA | -- |
GO:0009117 | nucleotide metabolic process | IEA | -- |
GO:0017144 | drug metabolic process | TAS | -- |
GO:0043101 | purine-containing compound salvage | TAS | -- |
GO:0043103 | NOT hypoxanthine salvage | IBA | -- |
No data available for SIGNOR curated interactions for ADAL Gene
Transcripts for ADAL Gene
mRNA/cDNA for ADAL Gene
- (14) REFSEQ mRNAs :
- (3) Additional mRNA sequences :
- (94) Selected AceView cDNA sequences:
- (8) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ADAL Gene
- Adenosine deaminase-like:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for ADAL
- genomics-online: gRNA clones - Search results for 74 available ADAL gene related products
- Overview of 74 available ADAL gene related products
- Applied Biological Materials CRISPR for ADAL
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ADAL
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miRNA Products
- Search ViGene Biosciences for ADAL
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for ADAL
- Browse OriGene Inhibitory RNA Products For ADAL
- genomics-online: shRNA clones - Search results for 74 available ADAL gene related products
- Overview of 74 available ADAL gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for ADAL gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Applied Biological Materials Clones for ADAL
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for ADAL Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ADAL Gene
NURSA nuclear receptor signaling pathways regulating expression of ADAL Gene:
ADALSOURCE GeneReport for Unigene cluster for ADAL Gene:
Hs.533913Evidence on tissue expression from TISSUES for ADAL Gene
- Nervous system(4.6)
Primer Products
-
OriGene qPCR primer pairs for ADAL
-
OriGene qPCR primer pairs and template standards for ADAL
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADAL Gene
Orthologs for ADAL Gene
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | ADAL 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | ADAL 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | ADAL 33 34 |
|
||
mouse (Mus musculus) |
Mammalia | Adal 33 16 34 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | ADAL 34 |
|
OneToOne | |
platypus (Ornithorhynchus anatinus) |
Mammalia | ADAL 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | ADAL 33 34 |
|
||
lizard (Anolis carolinensis) |
Reptilia | ADAL 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | adal 33 |
|
||
Str.12484 33 |
|
||||
zebrafish (Danio rerio) |
Actinopterygii | adal 33 34 |
|
||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP005158 33 |
|
||
fruit fly (Drosophila melanogaster) |
Insecta | Ada 33 34 |
|
||
worm (Caenorhabditis elegans) |
Secernentea | C44B7.12 33 34 |
|
||
thale cress (Arabidopsis thaliana) |
eudicotyledons | AT4G04880 33 |
|
||
rice (Oryza sativa) |
Liliopsida | Os07g0661000 33 |
|
||
sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToOne |
- Species where no ortholog for ADAL was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for ADAL Gene
Pseudogenes.org Pseudogenes for ADAL Gene
No data available for Paralogs for ADAL Gene
Variants for ADAL Gene
SNP ID | Clin | Chr 15 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000074569 | -- | 43,341,615(+) | G/T | intron_variant | |
rs1000136086 | -- | 43,341,024(+) | CTCTCT/CTCT | intron_variant | |
rs1000151571 | -- | 43,341,780(+) | A/G | intron_variant | |
rs1000218851 | -- | 43,352,299(+) | G/A | 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant | |
rs1000277097 | -- | 43,348,714(+) | A/T | intron_variant |
Additional Variant Information for ADAL Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ADAL
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADAL Gene
Disorders for ADAL Gene
Additional Disease Information for ADAL
No disorders were found for ADAL Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADAL Gene
Publications for ADAL Gene
- Mutations in adenosine deaminase-like (ADAL) protein confer resistance to the antiproliferative agents N6-cyclopropyl-PMEDAP and GS-9219. (PMID: 23645737) Frey CR … Cihlar T (Anticancer research 2013) 2 3 58
- Phylogenetic analysis reveals a novel protein family closely related to adenosine deaminase. (PMID: 16245011) Maier SA … McDermid HE (Journal of molecular evolution 2005) 2 3 58
- Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A … Hentze MW (Cell 2012) 3 58
- Adenosine deaminase-like protein 1 (ADAL1): characterization and substrate specificity in the hydrolysis of N(6)- or O(6)-substituted purine or 2-aminopurine nucleoside monophosphates. (PMID: 21755941) Murakami E … Furman PA (Journal of medicinal chemistry 2011) 3 58
- Analysis of the DNA sequence and duplication history of human chromosome 15. (PMID: 16572171) Zody MC … Nusbaum C (Nature 2006) 4 58
Products for ADAL Gene
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Sources for ADAL Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
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- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
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- (114) diseasecard
- (115) NIH Rare Diseases
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- (133) ENCODE
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- (135) Horizon
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- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
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- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew