ADAL Gene
protein-coding GIFtS: 43
GCID: GC15P043622
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adenosine deaminase-like
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Aliases
for ADAL gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Adenosine Deaminase-Like1 2 | | Adenosine Deaminase-Like Protein2 | | EC 3.5.4.-3 | | EC 3.5.48 |
Export aliases for ADAL gene to outside databasesPrevious GC identifers: GC15P041416 GC15P020471 |
Summaries
for ADAL gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ADAL_HUMAN, Q6DHV7Function: Putative nucleoside deaminase. May catalyze the hydrolytic deamination of adenosine or some similar substrateand play a role in purine metabolism (By similarity)
|
Genomic Views
for ADAL gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000015.9 NC_018926.1 NT_010194.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ADAL gene promoter:
TBP HTF POU3F2 Evi-1 NF-AT CHOP-10 NF-AT4 NF-AT2 NF-AT3 NF-AT1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ADAL
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADAL |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 15q15.3 Ensembl cytogenetic band: 15q15.3 HGNC cytogenetic band: 15q15.3ADAL Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 15 GeneLoc Exon Structure GeneLoc location for GC15P043622: view genomic region
(about GC identifiers)
Start:
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43,622,872 bp from pter |
End:
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43,646,096 bp from pter |
Size:
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23,225 bases |
Orientation:
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plus strand |
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Proteins
for ADAL gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ADAL_HUMAN, Q6DHV7 (See
protein sequence)Recommended Name: Adenosine deaminase-like protein Size: 355 amino acids; 40264 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Secondary accessions: A6NHZ3 B4DQM8Alternative splicing: 3 isoforms: Q6DHV7-1 Q6DHV7-2 Q6DHV7-3 Explore the universe of human proteins at neXtProt for ADAL: NX_Q6DHV7
4/5 DME Specific Peptides for ADAL (Q6DHV7) (see all 5)
ADAL Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001012987.1 NP_001152752.1
ENSEMBL proteins: ENSP00000413074 ENSP00000374302 ENSP00000455907 ENSP00000456242 ENSP00000457591 ENSP00000398744 Reactome Protein details: Q6DHV7
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005829 | cytosol |
TAS | -- |
ADAL for ontologies About GeneDecksing
ADAL Antibody Products:
Assay Products for ADAL: |
Protein
Domains /
Families
for ADAL gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ADAL for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q6DHV7ProtoNet protein and cluster: Q6DHV7 UniProtKB/Swiss-Prot: ADAL_HUMAN, Q6DHV7Similarity: Belongs to the adenosine and AMP deaminases family |
Function
for ADAL gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ADAL_HUMAN, Q6DHV7Function: Putative nucleoside deaminase. May catalyze the hydrolytic deamination of adenosine or some similar substrateand play a role in purine metabolism (By similarity)Enzyme Numbers (IUBMB): EC 3.5.42 EC 3.5.4.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADAL (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADAL (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): ADAL (NM_001012969) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ADAL | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADAL |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAL |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004000 | adenosine deaminase activity |
IBA | -- | | GO:0046872 | metal ion binding |
IEA | -- |
ADAL for ontologies About GeneDecksing
|
Pathways & Interactions
for ADAL gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Purine metabolism | | | 2 | Abacavir transport and metabolism | | | 3 | Metabolism | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/6 
Reactome Pathways for ADAL (see all 6)
ADAL for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ADAL
Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006144 | purine nucleobase metabolic process |
TAS | -- | | GO:0006154 | adenosine catabolic process |
IBA | -- | | GO:0009117 | nucleotide metabolic process |
IEA | -- | | GO:0009168 | purine ribonucleoside monophosphate biosynthetic process |
IEA | -- | | GO:0017144 | drug metabolic process |
TAS | -- |
ADAL for ontologies About GeneDecksing
|
Drugs & Compounds
for ADAL gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ADAL
Search CenterWatch for drugs/clinical trials and news about ADAL
|
Transcripts
for ADAL gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ADAL gene (2 alternative transcripts): NM_001012969.2 NM_001159280.1 Unigene Cluster for ADAL: Adenosine deaminase-like Hs.533913 [show with all ESTs]Unigene Representative Sequence: NM_0011592807 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000428046(uc010udo.2) ENST00000389651(uc001zrh.3) ENST00000565555
ENST00000563551 ENST00000562188 ENST00000566154 ENST00000422466(uc001zri.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADAL (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADAL (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): ADAL (NM_001012969) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ADAL | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADAL |
Additional cDNA sequence: AK126583.1 AK298870.1 BC075857.1 11 DOTS entries: DT.412202 DT.99983998 DT.99997537 DT.100683462 DT.121034813 DT.92417578 DT.100693900 DT.432612 DT.121034795 DT.95155463 DT.100705722 24/94 AceView cDNA sequences (see all 94): BI962698 AW593975 AA293426 AI123939 BC075857 AA044810 BM700326 BQ188219 CF529844 AI654975 AI080123 AA284726 BI789209 BX108368 BX647599 CK903307 BQ447767 CK903308 AA227487 AA284902 AI420327 BQ011595 BX108001 BQ012134
GeneLoc Exon Structure
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Expression
for ADAL gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ADAL expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAAAATCCCA
About this image
See ADAL Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ADAL
SOURCE GeneReport for Unigene cluster: Hs.533913
SABiosciences Custom PCR Arrays for ADAL
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ADAL
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ADAL | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADAL | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADAL | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAL |
Orthologs
for ADAL gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for ADAL gene from 9/25 species (see all 25) About this table
ENSEMBL Gene Tree for ADAL (if available)
TreeFam Gene Tree for ADAL (if available) |
Paralogs
for ADAL gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ADAL gene
- ADA2
ADAL for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for ADAL
PGOHUM00000242472
|
Genomic Variants
for ADAL gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 15 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ADAL (43622872 - 43646096 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ADAL: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ADAL |
|
Disorders
/ Diseases
for ADAL gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ADAL for disorders About GeneDecksing
5  diseases for ADAL: About MalaCardshyperopia epididymitis tuberculosis malaria
mycobacterium tuberculosis
1 disease from the University of Copenhagen DISEASES database for ADAL:Epididymitis Export disorders for ADAL gene to outside databases
|
Publications
for ADAL gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ADAL gene integrated from 9 sources:
(articles sorted by number of sources associating them with ADAL) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Adenosine deaminase-like protein 1 (ADAL1): character ization and substrate specificity in the hydrolysis of N(6)- or O(6)-substitute d purine or 2-aminopurine nucleoside monophosphates. (PubMed id 21755941)1 Murakami E....Furman P.A. (2011)
- Analysis of the DNA sequence and duplication history of human chromosome 15. (PubMed id 16572171)2 Zody M.C....Nusbaum C. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for ADAL gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ADAL gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ADAL gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ADAL gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ADAL | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ADAL gene:
Search GeneIP for patents involving ADAL
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ADAL gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ADAL | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ADAL | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ADAL | | | OriGene Protein Over-expression Lysate for ADAL | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ADAL | | OriGene 3'-UTR Clone for ADAL | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADAL | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADAL | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ADAL | | OriGene Custom Protein Services for ADAL | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ADAL | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ADAL | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADAL | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADAL | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADAL | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADAL |
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 |  |  |  | |
| | | | Search Tocris compounds for ADAL |
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 | | | ADAL Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAL |
|  |  |  | | | | Search ThermoFisher Antibodies for ADAL |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADAL |
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