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ADAL Gene(Protein Coding)

Adenosine Deaminase Like

GCID:
GC15P043330
GIFtS:
46
Genes Participants
UDN Logo

Aliases for ADAL Gene

Aliases for ADAL Gene

  • Adenosine Deaminase Like 2 3 5
  • EC 3.5.4.- 4
  • EC 3.5.4 61

External Ids for ADAL Gene

Previous GeneCards Identifiers for ADAL Gene

  • GC15P041416
  • GC15P043622
  • GC15P020471

Summaries for ADAL Gene

GeneCards Summary for ADAL Gene

ADAL (Adenosine Deaminase Like) is a Protein Coding gene. Among its related pathways are Metabolism and Abacavir transport and metabolism. GO annotations related to this gene include adenosine deaminase activity and deaminase activity.

UniProtKB/Swiss-Prot for ADAL Gene

  • Putative nucleoside deaminase. May catalyze the hydrolytic deamination of adenosine or some similar substrate and play a role in purine metabolism (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAL Gene

Genomics for ADAL Gene

Products:

  1. Regulatory Element

Regulatory Elements for ADAL Gene

Enhancers for ADAL Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F043328 1.1 ENCODE 48.8 -0.2 -170 3.0 PKNOX1 ARNT CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ADAL RPS3AP47 LRRC57 LCMT2 STRCP1 TGM7
GH15F043440 1.3 Ensembl ENCODE 40 +110.7 110736 2.0 HDGF ATF1 ARNT ARID4B SIN3A ZNF2 YY1 FOS DEK JUNB ADAL TGM7 MAP1A TP53BP1 PIR42778 PIR48108
GH15F043491 1 ENCODE 37.9 +162.9 162877 3.2 PKNOX1 ATF1 CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF48 BRCA1 ZNF2 ADAL ZSCAN29 TGM7 TUBGCP4 GC15M043494 PIR42778
GH15F043505 1.1 Ensembl ENCODE 34 +175.7 175681 1.5 KLF17 SIN3A ZNF121 SCRT2 EGR2 ZNF592 NFIL3 ZNF341 CEBPA IRF1 ADAL TGM7 GC15M043494 GC15M043498
GH15F043370 1 ENCODE 36.6 +40.7 40734 2.1 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 GLIS2 ELK1 ADAL TGM7 ZSCAN29 RN7SL487P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ADAL on UCSC Golden Path with GeneCards custom track

Promoters for ADAL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000020744 244 2000 PKNOX1 ARNT CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1

Transcription factor binding sites by QIAGEN in the ADAL gene promoter:

Genomic Location for ADAL Gene

Chromosome:
15
Start:
43,330,356 bp from pter
End:
43,354,555 bp from pter
Size:
24,200 bases
Orientation:
Plus strand

Genomic View for ADAL Gene

Genes around ADAL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADAL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADAL Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ADAL Gene

Proteins for ADAL Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for ADAL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6DHV7-ADAL_HUMAN
    Recommended name:
    Adenosine deaminase-like protein
    Protein Accession:
    Q6DHV7
    Secondary Accessions:
    • A6NHZ3
    • B4DQM8

    Protein attributes for ADAL Gene

    Size:
    355 amino acids
    Molecular mass:
    40264 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ADAL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADAL Gene

Protein Expression for ADAL Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for ADAL Gene

Q6DHV7:
  • PDRIGHGTFL
  • PKVELHAHL
  • VTKDVIKEFA
  • DGVKYLELRSTPR
  • HHFGFWY

Post-translational modifications for ADAL Gene

No Post-translational modifications

Other Protein References for ADAL Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for ADAL Gene

Gene Families for ADAL Gene

HGNC:

Protein Domains for ADAL Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ADAL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6DHV7

UniProtKB/Swiss-Prot:

ADAL_HUMAN :
  • Belongs to the adenosine and AMP deaminases family.
Family:
  • Belongs to the adenosine and AMP deaminases family.
genes like me logo Genes that share domains with ADAL: view

Function for ADAL Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for ADAL Gene

UniProtKB/Swiss-Prot Function:
Putative nucleoside deaminase. May catalyze the hydrolytic deamination of adenosine or some similar substrate and play a role in purine metabolism (By similarity).

Enzyme Numbers (IUBMB) for ADAL Gene

Gene Ontology (GO) - Molecular Function for ADAL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004000 adenosine deaminase activity IBA --
GO:0016787 hydrolase activity IEA --
GO:0019239 deaminase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ADAL: view
genes like me logo Genes that share phenotypes with ADAL: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ADAL

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ADAL Gene

Localization for ADAL Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADAL gene
Compartment Confidence
cytosol 5
cytoskeleton 2
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for ADAL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ADAL: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ADAL Gene

Pathways & Interactions for ADAL Gene

genes like me logo Genes that share pathways with ADAL: view

Pathways by source for ADAL Gene

Interacting Proteins for ADAL Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000413074%0d%0a9606.ENSP00000355689%0d%0a9606.ENSP00000367615%0d%0a9606.ENSP00000341044%0d%0a9606.ENSP00000344789%0d%0a9606.ENSP00000304697%0d%0a
Selected Interacting proteins: ENSP00000413074 Q6DHV7-ADAL_HUMAN for ADAL Gene via STRING IID

Gene Ontology (GO) - Biological Process for ADAL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006154 adenosine catabolic process IBA --
GO:0009117 nucleotide metabolic process IEA --
GO:0017144 drug metabolic process TAS --
GO:0043101 purine-containing compound salvage TAS --
GO:0043103 NOT hypoxanthine salvage IBA --
genes like me logo Genes that share ontologies with ADAL: view

No data available for SIGNOR curated interactions for ADAL Gene

Drugs & Compounds for ADAL Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for ADAL Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for ADAL Gene

(14) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(94) Selected AceView cDNA sequences:
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ADAL Gene

Adenosine deaminase-like:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADAL Gene

No ASD Table

Relevant External Links for ADAL Gene

GeneLoc Exon Structure for
ADAL
ECgene alternative splicing isoforms for
ADAL

Expression for ADAL Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ADAL Gene

mRNA expression in normal human tissues for ADAL Gene
mRNA expression by BioGPS for ADAL GenemRNA expression by GTEx for ADAL Gene

Protein differential expression in normal tissues from HIPED for ADAL Gene

This gene is overexpressed in Gallbladder (19.9), Heart (13.6), Tlymphocyte (11.7), and Retina (10.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ADAL Gene



Protein tissue co-expression partners for ADAL Gene

NURSA nuclear receptor signaling pathways regulating expression of ADAL Gene:

ADAL

SOURCE GeneReport for Unigene cluster for ADAL Gene:

Hs.533913
genes like me logo Genes that share expression patterns with ADAL: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ADAL Gene

Orthologs for ADAL Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ADAL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia ADAL 34 35
  • 99.7 (n)
dog
(Canis familiaris)
 Mammalia ADAL 34 35
  • 92.58 (n)
cow
(Bos Taurus)
 Mammalia ADAL 34 35
  • 89.13 (n)
mouse
(Mus musculus)
 Mammalia Adal 34 16 35
  • 84.36 (n)
oppossum
(Monodelphis domestica)
 Mammalia ADAL 35
  • 73 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia ADAL 35
  • 63 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves ADAL 34 35
  • 74.39 (n)
lizard
(Anolis carolinensis)
 Reptilia ADAL 35
  • 59 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia adal 34
  • 68.72 (n)
Str.12484 34
zebrafish
(Danio rerio)
 Actinopterygii adal 34 35
  • 62.94 (n)
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP005158 34
  • 50.28 (n)
fruit fly
(Drosophila melanogaster)
 Insecta Ada 34 35
  • 47.4 (n)
worm
(Caenorhabditis elegans)
 Secernentea C44B7.12 34 35
  • 46.49 (n)
thale cress
(Arabidopsis thaliana)
 eudicotyledons AT4G04880 34
  • 50.33 (n)
rice
(Oryza sativa)
 Liliopsida Os07g0661000 34
  • 51.54 (n)
sea squirt
(Ciona savignyi)
 Ascidiacea -- 35
  • 35 (a)
 OneToOne
Species where no ortholog for ADAL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADAL Gene

ENSEMBL:
Gene Tree for ADAL (if available)
TreeFam:
Gene Tree for ADAL (if available)

Paralogs for ADAL Gene

Pseudogenes.org Pseudogenes for ADAL Gene

genes like me logo Genes that share paralogs with ADAL: view

No data available for Paralogs for ADAL Gene

Variants for ADAL Gene

Sequence variations from dbSNP and Humsavar for ADAL Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1057479 -- 43,349,379(+) ATGTA(A/C)CATTA intron-variant, utr-variant-3-prime
rs10601991 -- 43,336,447(+) TCAGT(-/AATGT)TTTAT intron-variant
rs11070399 -- 43,354,149(+) GCTTG(A/G)TGGTG downstream-variant-500B, utr-variant-3-prime
rs111427654 -- 43,344,698(+) CAGCT(A/G)CTCAG intron-variant
rs111429563 -- 43,342,978(+) TTTTC(-/TA)TGTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADAL Gene

Variant ID Type Subtype PubMed ID
nsv1512 CNV deletion 18451855

Variation tolerance for ADAL Gene

Residual Variation Intolerance Score: 56.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.53; 44.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADAL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADAL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADAL Gene

Disorders for ADAL Gene

Relevant External Links for ADAL

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADAL

No disorders were found for ADAL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADAL Gene

Publications for ADAL Gene

  1. Mutations in adenosine deaminase-like (ADAL) protein confer resistance to the antiproliferative agents N6-cyclopropyl-PMEDAP and GS-9219. (PMID: 23645737) Frey C.R. … Cihlar T. (Anticancer Res. 2013) 2 3 64
  2. Phylogenetic analysis reveals a novel protein family closely related to adenosine deaminase. (PMID: 16245011) Maier S.A. … McDermid H.E. (J. Mol. Evol. 2005) 2 3 64
  3. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3 64
  4. Adenosine deaminase-like protein 1 (ADAL1): characterization and substrate specificity in the hydrolysis of N(6)- or O(6)-substituted purine or 2-aminopurine nucleoside monophosphates. (PMID: 21755941) Murakami E. … Furman P.A. (J. Med. Chem. 2011) 3 64
  5. Analysis of the DNA sequence and duplication history of human chromosome 15. (PMID: 16572171) Zody M.C. … Nusbaum C. (Nature 2006) 4 64

Products for ADAL Gene

Sources for ADAL Gene

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