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Aliases for ADAL Gene

Aliases for ADAL Gene

  • Adenosine Deaminase-Like 2 3
  • EC 3.5.4.- 4
  • EC 3.5.4 63

External Ids for ADAL Gene

Previous GeneCards Identifiers for ADAL Gene

  • GC15P041416
  • GC15P043622
  • GC15P020471

Summaries for ADAL Gene

GeneCards Summary for ADAL Gene

ADAL (Adenosine Deaminase-Like) is a Protein Coding gene. Among its related pathways are Metabolism and Purine metabolism. GO annotations related to this gene include adenosine deaminase activity and deaminase activity.

UniProtKB/Swiss-Prot for ADAL Gene

  • Putative nucleoside deaminase. May catalyze the hydrolytic deamination of adenosine or some similar substrate and play a role in purine metabolism (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAL Gene

Genomics for ADAL Gene

Regulatory Elements for ADAL Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ADAL Gene

Chromosome:
15
Start:
43,330,356 bp from pter
End:
43,354,555 bp from pter
Size:
24,200 bases
Orientation:
Plus strand

Genomic View for ADAL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADAL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAL Gene

Proteins for ADAL Gene

  • Protein details for ADAL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6DHV7-ADAL_HUMAN
    Recommended name:
    Adenosine deaminase-like protein
    Protein Accession:
    Q6DHV7
    Secondary Accessions:
    • A6NHZ3
    • B4DQM8

    Protein attributes for ADAL Gene

    Size:
    355 amino acids
    Molecular mass:
    40264 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ADAL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADAL Gene

Proteomics data for ADAL Gene at MOPED

Selected DME Specific Peptides for ADAL Gene

Post-translational modifications for ADAL Gene

No Post-translational modifications

Domains & Families for ADAL Gene

Protein Domains for ADAL Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ADAL Gene

Graphical View of Domain Structure for InterPro Entry

Q6DHV7

UniProtKB/Swiss-Prot:

ADAL_HUMAN :
  • Belongs to the adenosine and AMP deaminases family.
Family:
  • Belongs to the adenosine and AMP deaminases family.
genes like me logo Genes that share domains with ADAL: view

No data available for Gene Families for ADAL Gene

Function for ADAL Gene

Molecular function for ADAL Gene

UniProtKB/Swiss-Prot Function:
Putative nucleoside deaminase. May catalyze the hydrolytic deamination of adenosine or some similar substrate and play a role in purine metabolism (By similarity).

Enzyme Numbers (IUBMB) for ADAL Gene

Gene Ontology (GO) - Molecular Function for ADAL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004000 adenosine deaminase activity IBA --
GO:0019239 deaminase activity --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ADAL: view
genes like me logo Genes that share phenotypes with ADAL: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADAL

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ADAL Gene

Localization for ADAL Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADAL Gene COMPARTMENTS Subcellular localization image for ADAL gene
Compartment Confidence
cytosol 4
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for ADAL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ADAL: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ADAL Gene

Pathways & Interactions for ADAL Gene

genes like me logo Genes that share pathways with ADAL: view

Pathways by source for ADAL Gene

Interacting Proteins for ADAL Gene

Gene Ontology (GO) - Biological Process for ADAL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006144 purine nucleobase metabolic process TAS --
GO:0006154 adenosine catabolic process IBA --
GO:0009117 nucleotide metabolic process IEA --
GO:0017144 drug metabolic process TAS --
GO:0043101 purine-containing compound salvage TAS --
genes like me logo Genes that share ontologies with ADAL: view

No data available for SIGNOR curated interactions for ADAL Gene

Drugs & Compounds for ADAL Gene

No Compound Related Data Available

Transcripts for ADAL Gene

Unigene Clusters for ADAL Gene

Adenosine deaminase-like:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADAL

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADAL Gene

No ASD Table

Relevant External Links for ADAL Gene

GeneLoc Exon Structure for
ADAL
ECgene alternative splicing isoforms for
ADAL

Expression for ADAL Gene

mRNA expression in normal human tissues for ADAL Gene

Protein differential expression in normal tissues from HIPED for ADAL Gene

This gene is overexpressed in Gallbladder (19.9), Heart (13.6), Tlymphocyte (11.7), and Retina (10.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ADAL Gene



SOURCE GeneReport for Unigene cluster for ADAL Gene Hs.533913

genes like me logo Genes that share expression patterns with ADAL: view

Protein tissue co-expression partners for ADAL Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ADAL Gene

Orthologs for ADAL Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ADAL Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ADAL 35
  • 89.13 (n)
  • 84.78 (a)
ADAL 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADAL 35
  • 92.58 (n)
  • 91.16 (a)
ADAL 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adal 35
  • 84.36 (n)
  • 83.44 (a)
Adal 16
Adal 36
  • 75 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ADAL 35
  • 99.7 (n)
  • 99.7 (a)
ADAL 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ADAL 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ADAL 36
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves ADAL 35
  • 74.39 (n)
  • 74.13 (a)
ADAL 36
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADAL 36
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia adal 35
  • 68.72 (n)
  • 66.56 (a)
Str.12484 35
zebrafish
(Danio rerio)
Actinopterygii adal 35
  • 62.94 (n)
  • 63.9 (a)
adal 36
  • 57 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005158 35
  • 50.28 (n)
  • 45.79 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ada 35
  • 47.4 (n)
  • 42.2 (a)
Ada 36
  • 33 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C44B7.12 35
  • 46.49 (n)
  • 34.54 (a)
C44B7.12 36
  • 27 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G04880 35
  • 50.33 (n)
  • 41.67 (a)
rice
(Oryza sativa)
Liliopsida Os07g0661000 35
  • 51.54 (n)
  • 41.45 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
OneToOne
Species with no ortholog for ADAL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADAL Gene

ENSEMBL:
Gene Tree for ADAL (if available)
TreeFam:
Gene Tree for ADAL (if available)

Paralogs for ADAL Gene

Pseudogenes.org Pseudogenes for ADAL Gene

genes like me logo Genes that share paralogs with ADAL: view

No data available for Paralogs for ADAL Gene

Variants for ADAL Gene

Sequence variations from dbSNP and Humsavar for ADAL Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs933941 -- 43,340,028(+) CTGAT(A/G)TGCAG intron-variant
rs933942 -- 43,343,344(+) TACAA(G/T)GTCCC intron-variant
rs1057479 -- 43,349,379(+) ATGTA(A/C)CATTA utr-variant-3-prime, intron-variant
rs1123947 -- 43,333,235(+) TGAGA(C/T)CCCGT intron-variant, upstream-variant-2KB
rs1426753 -- 43,342,676(+) GCTCA(A/G)GAGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADAL Gene

Variant ID Type Subtype PubMed ID
nsv1512 CNV Loss 18451855

Variation tolerance for ADAL Gene

Residual Variation Intolerance Score: 56.26% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.53; 44.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADAL Gene

HapMap Linkage Disequilibrium report
ADAL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADAL Gene

Disorders for ADAL Gene

Relevant External Links for ADAL

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADAL
genes like me logo Genes that share disorders with ADAL: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADAL Gene

Publications for ADAL Gene

  1. Mutations in adenosine deaminase-like (ADAL) protein confer resistance to the antiproliferative agents N6-cyclopropyl-PMEDAP and GS-9219. (PMID: 23645737) Frey C.R. … Cihlar T. (Anticancer Res. 2013) 67
  2. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 67
  3. Adenosine deaminase-like protein 1 (ADAL1): characterization and substrate specificity in the hydrolysis of N(6)- or O(6)-substituted purine or 2-aminopurine nucleoside monophosphates. (PMID: 21755941) Murakami E. … Furman P.A. (J. Med. Chem. 2011) 67
  4. Analysis of the DNA sequence and duplication history of human chromosome 15. (PMID: 16572171) Zody M.C. … Nusbaum C. (Nature 2006) 67
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67

Products for ADAL Gene

Sources for ADAL Gene

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