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Aliases for ADAL Gene

Aliases for ADAL Gene

  • Adenosine Deaminase-Like 2 3
  • EC 3.5.4.- 4
  • EC 3.5.4 64

External Ids for ADAL Gene

Summaries for ADAL Gene

GeneCards Summary for ADAL Gene

ADAL (Adenosine Deaminase-Like) is a Protein Coding gene. Diseases associated with ADAL include epididymitis. Among its related pathways are Metabolism and Purine metabolism (REACTOME). GO annotations related to this gene include adenosine deaminase activity.

UniProtKB/Swiss-Prot for ADAL Gene

  • Putative nucleoside deaminase. May catalyze the hydrolytic deamination of adenosine or some similar substrate and play a role in purine metabolism (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAL Gene

Genomics for ADAL Gene

Genomic Location for ADAL Gene

Start:
43,330,356 bp from pter
End:
43,354,555 bp from pter
Size:
24,200 bases
Orientation:
Plus strand

Genomic View for ADAL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADAL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAL Gene

Regulatory Elements for ADAL Gene

Proteins for ADAL Gene

  • Protein details for ADAL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6DHV7-ADAL_HUMAN
    Recommended name:
    Adenosine deaminase-like protein
    Protein Accession:
    Q6DHV7
    Secondary Accessions:
    • A6NHZ3
    • B4DQM8

    Protein attributes for ADAL Gene

    Size:
    355 amino acids
    Molecular mass:
    40264 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ADAL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADAL Gene

Proteomics data for ADAL Gene at MOPED

Selected DME Specific Peptides for ADAL Gene

Post-translational modifications for ADAL Gene

No Post-translational modifications

Other Protein References for ADAL Gene

Domains for ADAL Gene

Protein Domains for ADAL Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

ADAL_HUMAN
Family:
  • Belongs to the adenosine and AMP deaminases family.:
    • Q6DHV7
genes like me logo Genes that share domains with ADAL: view

No data available for Gene Families for ADAL Gene

Function for ADAL Gene

Molecular function for ADAL Gene

UniProtKB/Swiss-Prot Function: Putative nucleoside deaminase. May catalyze the hydrolytic deamination of adenosine or some similar substrate and play a role in purine metabolism (By similarity).

Enzyme Numbers (IUBMB) for ADAL Gene

Gene Ontology (GO) - Molecular Function for ADAL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004000 adenosine deaminase activity IBA --
GO:0019239 deaminase activity --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ADAL: view

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ADAL Gene

Localization for ADAL Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADAL Gene COMPARTMENTS Subcellular localization image for ADAL gene
Compartment Confidence
cytosol 4
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for ADAL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ADAL: view

Pathways for ADAL Gene

genes like me logo Genes that share pathways with ADAL: view

Pathways by source for ADAL Gene

Interacting Proteins for ADAL Gene

Gene Ontology (GO) - Biological Process for ADAL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006144 purine nucleobase metabolic process TAS --
GO:0006154 adenosine catabolic process IBA --
GO:0009117 nucleotide metabolic process IEA --
GO:0017144 drug metabolic process TAS --
GO:0043101 purine-containing compound salvage TAS --
genes like me logo Genes that share ontologies with ADAL: view

Transcripts for ADAL Gene

Unigene Clusters for ADAL Gene

Adenosine deaminase-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ADAL Gene

No ASD Table

Relevant External Links for ADAL Gene

GeneLoc Exon Structure for
ADAL
ECgene alternative splicing isoforms for
ADAL

Expression for ADAL Gene

mRNA expression in normal human tissues for ADAL Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ADAL Gene

SOURCE GeneReport for Unigene cluster for ADAL Gene Hs.533913

genes like me logo Genes that share expressions with ADAL: view

Orthologs for ADAL Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ADAL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADAL 36
  • 99.7 (n)
  • 99.7 (a)
ADAL 37
  • 92 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ADAL 36
  • 89.13 (n)
  • 84.78 (a)
ADAL 37
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADAL 36
  • 92.58 (n)
  • 91.16 (a)
ADAL 37
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adal 36
  • 84.36 (n)
  • 83.44 (a)
Adal 16
Adal 37
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ADAL 37
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ADAL 37
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves ADAL 36
  • 74.39 (n)
  • 74.13 (a)
ADAL 37
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADAL 37
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia adal 36
  • 68.72 (n)
  • 66.56 (a)
Str.12484 36
zebrafish
(Danio rerio)
Actinopterygii adal 36
  • 62.94 (n)
  • 63.9 (a)
adal 37
  • 57 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005158 36
  • 50.28 (n)
  • 45.79 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ada 36
  • 47.4 (n)
  • 42.2 (a)
Ada 37
  • 33 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C44B7.12 36
  • 46.49 (n)
  • 34.54 (a)
C44B7.12 37
  • 27 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G04880 36
  • 50.33 (n)
  • 41.67 (a)
rice
(Oryza sativa)
Liliopsida Os07g0661000 36
  • 51.54 (n)
  • 41.45 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 35 (a)
OneToOne
Species with no ortholog for ADAL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADAL Gene

ENSEMBL:
Gene Tree for ADAL (if available)
TreeFam:
Gene Tree for ADAL (if available)

Paralogs for ADAL Gene

Pseudogenes.org Pseudogenes for ADAL Gene

genes like me logo Genes that share paralogs with ADAL: view

No data available for Paralogs for ADAL Gene

Variants for ADAL Gene

Sequence variations from dbSNP and Humsavar for ADAL Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs933941 -- 43,340,028(+) CTGAT(A/G)TGCAG intron-variant
rs933942 -- 43,343,344(+) TACAA(G/T)GTCCC intron-variant
rs1057479 -- 43,349,379(+) ATGTA(A/C)CATTA utr-variant-3-prime, intron-variant
rs1123947 -- 43,333,235(+) TGAGA(C/T)CCCGT intron-variant, upstream-variant-2KB
rs1426753 -- 43,342,676(+) GCTCA(A/G)GAGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADAL Gene

Variant ID Type Subtype PubMed ID
nsv1512 CNV Loss 18451855

Relevant External Links for ADAL Gene

HapMap Linkage Disequilibrium report
ADAL

Disorders for ADAL Gene

(1) MalaCards Diseases for ADAL Gene

Search for ADAL Gene in MalaCards »

(1) University of Copenhagen DISEASES for ADAL Gene

genes like me logo Genes that share disorders with ADAL: view

No data available for UniProtKB/Swiss-Prot for ADAL Gene

Publications for ADAL Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  2. Adenosine deaminase-like protein 1 (ADAL1): characterization and substrate specificity in the hydrolysis of N(6)- or O(6)-substituted purine or 2-aminopurine nucleoside monophosphates. (PMID: 21755941) Murakami E. … Furman P.A. (J. Med. Chem. 2011) 3
  3. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3
  4. Mutations in adenosine deaminase-like (ADAL) protein confer resistance to the antiproliferative agents N6-cyclopropyl-PMEDAP and GS-9219. (PMID: 23645737) Frey C.R. … Cihlar T. (Anticancer Res. 2013) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4

Products for ADAL Gene

Sources for ADAL Gene

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