Aliases for ADAL Gene
External Ids for ADAL Gene
- HGNC: 31853
- Entrez Gene: 161823
- Ensembl: ENSG00000168803
- UniProtKB: Q6DHV7
Previous GeneCards Identifiers for ADAL Gene
- GC15P041416
- GC15P043622
- GC15P020471
Summaries for ADAL Gene
GeneCards Summary for ADAL Gene
ADAL (Adenosine Deaminase Like) is a Protein Coding gene. Among its related pathways are Metabolism and Abacavir transport and metabolism. Gene Ontology (GO) annotations related to this gene include adenosine deaminase activity and deaminase activity.
UniProtKB/Swiss-Prot for ADAL Gene
-
Putative nucleoside deaminase. May catalyze the hydrolytic deamination of adenosine or some similar substrate and play a role in purine metabolism (By similarity).
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAL Gene
Genomics for ADAL Gene
GeneHancer (GH) Regulatory Elements for ADAL Gene
Promoters and enhancers for ADAL Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around ADAL on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for ADAL Gene
Genomic Locations for ADAL Gene
- chr15:43,330,356-43,354,555
- (GRCh38/hg38)
- Size:
- 24,200 bases
- Orientation:
- Plus strand
- chr15:43,622,872-43,646,096
- (GRCh37/hg19)
Genomic View for ADAL Gene
Genes around ADAL on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 15q15.3 by Ensembl
- 15q15.3 by Entrez Gene
- 15q15.3 by HGNC
ADAL Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ADAL Gene
Proteins for ADAL Gene
-
Protein details for ADAL Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q6DHV7-ADAL_HUMAN
- Recommended name:
- Adenosine deaminase-like protein
- Protein Accession:
- Q6DHV7
- A6NHZ3
- B4DQM8
Protein attributes for ADAL Gene
- Size:
- 355 amino acids
- Molecular mass:
- 40264 Da
- Cofactor:
- Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Quaternary structure:
- No Data Available
Protein Expression for ADAL Gene
Selected DME Specific Peptides for ADAL Gene
- Q6DHV7:
-
- PDRIGHGTFL
- PKVELHAHL
- VTKDVIKEFA
- DGVKYLELRSTPR
- HHFGFWY
Post-translational modifications for ADAL Gene
No Post-translational modifications
Other Protein References for ADAL Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for ADAL
- Invitrogen Antibodies for ADAL
- Search GeneTex for Antibodies for ADAL
Protein Products
-
OriGene Purified Proteins for ADAL
- Search Origene for MassSpec and Protein Over-expression Lysates for ADAL
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- ProSpec Recombinant Proteins for ADAL
- Search GeneTex for Proteins for ADAL
Assay Products
Domains & Families for ADAL Gene
Gene Families for ADAL Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for ADAL Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for ADAL Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q6DHV7UniProtKB/Swiss-Prot:
ADAL_HUMAN :- Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.
- Family:
-
- Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.
Function for ADAL Gene
Molecular function for ADAL Gene
- UniProtKB/Swiss-Prot Function:
- Putative nucleoside deaminase. May catalyze the hydrolytic deamination of adenosine or some similar substrate and play a role in purine metabolism (By similarity).
Enzyme Numbers (IUBMB) for ADAL Gene
Phenotypes From GWAS Catalog for ADAL Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004000 | adenosine deaminase activity | IBA | -- |
| GO:0016787 | hydrolase activity | IEA | -- |
| GO:0019239 | deaminase activity | IEA | -- |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for ADAL Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for ADAL gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ADAL gene
- Search ViGene Biosciences for ADAL
CRISPR Products
-
OriGene CRISPR knockouts for ADAL
- genomics-online: gRNA clones - Search results for 74 available ADAL gene related products
- Overview of 74 available ADAL gene related products
- Applied Biological Materials CRISPR for ADAL
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ADAL
- GenScript: Design CRISPR guide RNA sequences for ADAL
miRNA Products
- Search ViGene Biosciences for ADAL
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for ADAL
- Browse OriGene Inhibitory RNA Products For ADAL
- genomics-online: shRNA clones - Search results for 74 available ADAL gene related products
- Overview of 74 available ADAL gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for ADAL gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Applied Biological Materials Clones for ADAL
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for ADAL
-
ViGene Biosciences adenoviral particle packaged cDNA for ADAL gene
-
ViGene Biosciences lentiviral particle packaged cDNA for ADAL gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ADAL gene
No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ADAL Gene
Localization for ADAL Gene
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| cytoskeleton | 2 |
| nucleus | 2 |
| peroxisome | 1 |
- Microtubules (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005829 | cytosol | TAS | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for ADAL Gene
Pathways & Interactions for ADAL Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Purine metabolism |
.01
|
|
| 2 | Abacavir transport and metabolism | ||
| 3 | Metabolism |
.37
|
|
Pathways by source for ADAL Gene
6 Reactome pathways for ADAL Gene
Interacting Proteins for ADAL Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006154 | adenosine catabolic process | IBA | -- |
| GO:0009117 | nucleotide metabolic process | IEA | -- |
| GO:0017144 | drug metabolic process | TAS | -- |
| GO:0043101 | purine-containing compound salvage | TAS | -- |
| GO:0043103 | NOT hypoxanthine salvage | IBA | -- |
No data available for SIGNOR curated interactions for ADAL Gene
Transcripts for ADAL Gene
mRNA/cDNA for ADAL Gene
- (14) REFSEQ mRNAs :
- (3) Additional mRNA sequences :
- (94) Selected AceView cDNA sequences:
- (8) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ADAL Gene
- Adenosine deaminase-like:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for ADAL
- genomics-online: gRNA clones - Search results for 74 available ADAL gene related products
- Overview of 74 available ADAL gene related products
- Applied Biological Materials CRISPR for ADAL
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ADAL
- GenScript: Design CRISPR guide RNA sequences for ADAL
miRNA Products
- Search ViGene Biosciences for ADAL
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for ADAL
- Browse OriGene Inhibitory RNA Products For ADAL
- genomics-online: shRNA clones - Search results for 74 available ADAL gene related products
- Overview of 74 available ADAL gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for ADAL gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Applied Biological Materials Clones for ADAL
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for ADAL Gene
This gene is overexpressed in Gallbladder (19.9), Heart (13.6), Tlymphocyte (11.7), and Retina (10.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ADAL Gene
NURSA nuclear receptor signaling pathways regulating expression of ADAL Gene:
ADALSOURCE GeneReport for Unigene cluster for ADAL Gene:
Hs.533913Evidence on tissue expression from TISSUES for ADAL Gene
- Nervous system(4.6)
Primer Products
-
OriGene qPCR primer pairs for ADAL
-
OriGene qPCR primer pairs and template standards for ADAL
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADAL Gene
Orthologs for ADAL Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ADAL 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | ADAL 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | ADAL 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Adal 33 16 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | ADAL 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | ADAL 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ADAL 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | ADAL 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | adal 33 |
|
||
| Str.12484 33 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | adal 33 34 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP005158 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Ada 33 34 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | C44B7.12 33 34 |
|
||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | AT4G04880 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os07g0661000 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToOne |
- Species where no ortholog for ADAL was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for ADAL Gene
Pseudogenes.org Pseudogenes for ADAL Gene
No data available for Paralogs for ADAL Gene
Variants for ADAL Gene
| SNP ID | Clin | Chr 15 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000074569 | -- | 43,341,615(+) | G/T | intron_variant | |
| rs1000136086 | -- | 43,341,024(+) | CTCTCT/CTCT | intron_variant | |
| rs1000151571 | -- | 43,341,780(+) | A/G | intron_variant | |
| rs1000218851 | -- | 43,352,299(+) | G/A | 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant | |
| rs1000277097 | -- | 43,348,714(+) | A/T | intron_variant |
Residual Variation Intolerance Score:
56.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.53;
44.15% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ADAL Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ADAL
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADAL Gene
Disorders for ADAL Gene
Additional Disease Information for ADAL
No disorders were found for ADAL Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADAL Gene
Publications for ADAL Gene
- Mutations in adenosine deaminase-like (ADAL) protein confer resistance to the antiproliferative agents N6-cyclopropyl-PMEDAP and GS-9219. (PMID: 23645737) Frey CR … Cihlar T (Anticancer research 2013) 2 3 58
- Phylogenetic analysis reveals a novel protein family closely related to adenosine deaminase. (PMID: 16245011) Maier SA … McDermid HE (Journal of molecular evolution 2005) 2 3 58
- Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A … Hentze MW (Cell 2012) 3 58
- Adenosine deaminase-like protein 1 (ADAL1): characterization and substrate specificity in the hydrolysis of N(6)- or O(6)-substituted purine or 2-aminopurine nucleoside monophosphates. (PMID: 21755941) Murakami E … Furman PA (Journal of medicinal chemistry 2011) 3 58
- Analysis of the DNA sequence and duplication history of human chromosome 15. (PMID: 16572171) Zody MC … Nusbaum C (Nature 2006) 4 58
Products for ADAL Gene
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- Invitrogen Antibodies for ADAL
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- Overview of 74 available ADAL gene related products
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- Overview of 74 available ADAL gene related products
Sources for ADAL Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew