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Aliases for ADAL Gene

Aliases for ADAL Gene

  • Adenosine Deaminase-Like 2 3
  • EC 3.5.4.- 4
  • EC 3.5.4 63

External Ids for ADAL Gene

Previous GeneCards Identifiers for ADAL Gene

  • GC15P041416
  • GC15P043622
  • GC15P020471

Summaries for ADAL Gene

GeneCards Summary for ADAL Gene

ADAL (Adenosine Deaminase-Like) is a Protein Coding gene. Diseases associated with ADAL include epididymitis. Among its related pathways are Metabolism and Purine metabolism (REACTOME). GO annotations related to this gene include adenosine deaminase activity.

UniProtKB/Swiss-Prot for ADAL Gene

  • Putative nucleoside deaminase. May catalyze the hydrolytic deamination of adenosine or some similar substrate and play a role in purine metabolism (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAL Gene

Genomics for ADAL Gene

Regulatory Elements for ADAL Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ADAL Gene

43,330,356 bp from pter
43,354,555 bp from pter
24,200 bases
Plus strand

Genomic View for ADAL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADAL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAL Gene

Proteins for ADAL Gene

  • Protein details for ADAL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Adenosine deaminase-like protein
    Protein Accession:
    Secondary Accessions:
    • A6NHZ3
    • B4DQM8

    Protein attributes for ADAL Gene

    355 amino acids
    Molecular mass:
    40264 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ADAL Gene


neXtProt entry for ADAL Gene

Proteomics data for ADAL Gene at MOPED

Selected DME Specific Peptides for ADAL Gene

Post-translational modifications for ADAL Gene

No Post-translational modifications

Other Protein References for ADAL Gene

Domains for ADAL Gene

Protein Domains for ADAL Gene


Suggested Antigen Peptide Sequences for ADAL Gene

Graphical View of Domain Structure for InterPro Entry



  • Q6DHV7
  • Belongs to the adenosine and AMP deaminases family.
genes like me logo Genes that share domains with ADAL: view

No data available for Gene Families for ADAL Gene

Function for ADAL Gene

Molecular function for ADAL Gene

UniProtKB/Swiss-Prot Function: Putative nucleoside deaminase. May catalyze the hydrolytic deamination of adenosine or some similar substrate and play a role in purine metabolism (By similarity).

Enzyme Numbers (IUBMB) for ADAL Gene

Gene Ontology (GO) - Molecular Function for ADAL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004000 adenosine deaminase activity IBA --
GO:0019239 deaminase activity --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ADAL: view

Animal Model Products

CRISPR Products

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ADAL Gene

Localization for ADAL Gene

Subcellular locations from

Jensen Localization Image for ADAL Gene COMPARTMENTS Subcellular localization image for ADAL gene
Compartment Confidence
cytosol 4
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for ADAL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ADAL: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ADAL Gene

Pathways for ADAL Gene

genes like me logo Genes that share pathways with ADAL: view

Pathways by source for ADAL Gene

Interacting Proteins for ADAL Gene

Gene Ontology (GO) - Biological Process for ADAL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006144 purine nucleobase metabolic process TAS --
GO:0006154 adenosine catabolic process IBA --
GO:0009117 nucleotide metabolic process IEA --
GO:0017144 drug metabolic process TAS --
GO:0043101 purine-containing compound salvage TAS --
genes like me logo Genes that share ontologies with ADAL: view

Transcripts for ADAL Gene

Unigene Clusters for ADAL Gene

Adenosine deaminase-like:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADAL

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADAL Gene

No ASD Table

Relevant External Links for ADAL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ADAL Gene

mRNA expression in normal human tissues for ADAL Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ADAL Gene

SOURCE GeneReport for Unigene cluster for ADAL Gene Hs.533913

genes like me logo Genes that share expressions with ADAL: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ADAL Gene

Orthologs for ADAL Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ADAL Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ADAL 35
  • 99.7 (n)
  • 99.7 (a)
  • 92 (a)
(Bos Taurus)
Mammalia ADAL 35
  • 89.13 (n)
  • 84.78 (a)
  • 78 (a)
(Canis familiaris)
Mammalia ADAL 35
  • 92.58 (n)
  • 91.16 (a)
  • 84 (a)
(Mus musculus)
Mammalia Adal 35
  • 84.36 (n)
  • 83.44 (a)
Adal 16
Adal 36
  • 75 (a)
(Monodelphis domestica)
Mammalia ADAL 36
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia ADAL 36
  • 63 (a)
(Gallus gallus)
Aves ADAL 35
  • 74.39 (n)
  • 74.13 (a)
  • 66 (a)
(Anolis carolinensis)
Reptilia ADAL 36
  • 59 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia adal 35
  • 68.72 (n)
  • 66.56 (a)
Str.12484 35
(Danio rerio)
Actinopterygii adal 35
  • 62.94 (n)
  • 63.9 (a)
adal 36
  • 57 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005158 35
  • 50.28 (n)
  • 45.79 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ada 35
  • 47.4 (n)
  • 42.2 (a)
Ada 36
  • 33 (a)
(Caenorhabditis elegans)
Secernentea C44B7.12 35
  • 46.49 (n)
  • 34.54 (a)
C44B7.12 36
  • 27 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G04880 35
  • 50.33 (n)
  • 41.67 (a)
(Oryza sativa)
Liliopsida Os07g0661000 35
  • 51.54 (n)
  • 41.45 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
Species with no ortholog for ADAL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADAL Gene

Gene Tree for ADAL (if available)
Gene Tree for ADAL (if available)

Paralogs for ADAL Gene Pseudogenes for ADAL Gene

genes like me logo Genes that share paralogs with ADAL: view

No data available for Paralogs for ADAL Gene

Variants for ADAL Gene

Sequence variations from dbSNP and Humsavar for ADAL Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs933941 -- 43,340,028(+) CTGAT(A/G)TGCAG intron-variant
rs933942 -- 43,343,344(+) TACAA(G/T)GTCCC intron-variant
rs1057479 -- 43,349,379(+) ATGTA(A/C)CATTA utr-variant-3-prime, intron-variant
rs1123947 -- 43,333,235(+) TGAGA(C/T)CCCGT intron-variant, upstream-variant-2KB
rs1426753 -- 43,342,676(+) GCTCA(A/G)GAGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADAL Gene

Variant ID Type Subtype PubMed ID
nsv1512 CNV Loss 18451855

Relevant External Links for ADAL Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADAL Gene

Disorders for ADAL Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for ADAL Gene including...

Search for ADAL Gene in MalaCards »

(1) University of Copenhagen DISEASES for ADAL Gene

genes like me logo Genes that share disorders with ADAL: view

No data available for UniProtKB/Swiss-Prot for ADAL Gene

Publications for ADAL Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  2. Adenosine deaminase-like protein 1 (ADAL1): characterization and substrate specificity in the hydrolysis of N(6)- or O(6)-substituted purine or 2-aminopurine nucleoside monophosphates. (PMID: 21755941) Murakami E. … Furman P.A. (J. Med. Chem. 2011) 3
  3. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3
  4. Mutations in adenosine deaminase-like (ADAL) protein confer resistance to the antiproliferative agents N6-cyclopropyl-PMEDAP and GS-9219. (PMID: 23645737) Frey C.R. … Cihlar T. (Anticancer Res. 2013) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4

Products for ADAL Gene

Sources for ADAL Gene

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