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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ADAL Gene

protein-coding GIFtS: 44
GCID: GC15P043622

Adenosine Deaminase-Like

3 related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Adenosine Deaminase-Like¹ ²
Adenosine Deaminase-Like Protein²
EC 3.5.4.-³
EC 3.5.4⁸

External Ids:	HGNC: 31853¹	Entrez Gene: 161823²	Ensembl: ENSG00000168803⁷	UniProtKB: Q6DHV7³

Export aliases for ADAL gene to outside databases

Previous GC identifers: GC15P041416 GC15P020471

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ADAL Gene:

ADAL (adenosine deaminase-like) is a protein-coding gene. Diseases associated with ADAL include hyperopia, and epididymitis, and among its related super-pathways are Metabolism of nucleotides and Abacavir metabolism. GO annotations related to this gene include adenosine deaminase activity and metal ion binding.

UniProtKB/Swiss-Prot: ADAL_HUMAN, Q6DHV7

Function: Putative nucleoside deaminase. May catalyze the hydrolytic deamination of adenosine or some similar

substrate and play a role in purine metabolism (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000015.9 NT_010194.17 NC_018926.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ADAL gene promoter:
TBP HTF POU3F2 Evi-1 NF-AT CHOP-10 NF-AT4 NF-AT2 NF-AT3 NF-AT1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ADAL promoter sequence

Search SABiosciences Chromatin IP Primers for ADAL

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADAL

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q15.3 Ensembl cytogenetic band: 15q15.3 HGNC cytogenetic band: 15q15.3

ADAL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADAL gene location

GeneLoc information about chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15P043622: view genomic region (about GC identifiers)

Start:	43,622,872 bp from pter	End:	43,646,096 bp from pter
Size:	23,225 bases	Orientation:	plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ADAL_HUMAN, Q6DHV7 (See protein sequence)

Recommended Name: Adenosine deaminase-like protein

Size: 355 amino acids; 40264 Da

Cofactor: Binds 1 zinc ion per subunit (By similarity)

Secondary accessions: A6NHZ3 B4DQM8

Alternative splicing: 3 isoforms: Q6DHV7-1 Q6DHV7-2 Q6DHV7-3

Explore the universe of human proteins at neXtProt for ADAL: NX_Q6DHV7

Explore proteomics data for ADAL at MOPED

4/5 DME Specific Peptides for ADAL (Q6DHV7) (see all 5)

HHFGFWY

PKVELHAHL

PDRIGHGTFL

VTKDVIKEFA

ADAL Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins (2 alternative transcripts):

NP_001012987.1 NP_001152752.1

ENSEMBL proteins:

ENSP00000413074 ENSP00000374302 ENSP00000455907 ENSP00000456242 ENSP00000457591

ENSP00000398744

Reactome Protein details: Q6DHV7
Human Recombinant Protein Products for ADAL:

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	Novus Biologicals ADAL Protein Novus Biologicals ADAL Lysates
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for ADAL

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005829	cytosol	TAS	--

ADAL for ontologies About GeneDecksing

ADAL Antibody Products:

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	LSBio Antibodies in human, mouse, rat for ADAL

Assay Products for ADAL:

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

1 InterPro protein domain:

IPR001365 A/AMP_deaminase_dom

Graphical View of Domain Structure for InterPro Entry Q6DHV7

ProtoNet protein and cluster: Q6DHV7

UniProtKB/Swiss-Prot: ADAL_HUMAN, Q6DHV7

Similarity: Belongs to the adenosine and AMP deaminases family

ADAL for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: ADAL_HUMAN, Q6DHV7

Function: Putative nucleoside deaminase. May catalyze the hydrolytic deamination of adenosine or some similar

substrate and play a role in purine metabolism (By similarity)

Enzyme Numbers (IUBMB): EC 3.5.4² EC 3.5.4.-¹

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004000	adenosine deaminase activity	IBA	--
GO:0019239	deaminase activity	--	--
GO:0046872	metal ion binding	IEA	--

ADAL for ontologies About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Custom generated mouse model solutions for ADAL

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ADAL

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ADAL

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ADAL

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ADAL
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate ADAL:
		hsa-miR-576-5p hsa-miR-3920 hsa-miR-29a*
		SwitchGear 3'UTR luciferase reporter plasmid: ADAL 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for ADAL
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADAL

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for ADAL
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene clones in human, mouse for ADAL (see all 14) OriGene ORF clones in mouse, rat for ADAL OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): ADAL (NM_001012969)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADAL
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADAL
		Sirion Biotech Customized lentivirus for stable overexpression of ADAL Customized lentivirus expression plasmids for stable overexpression of ADAL

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ADAL
		Search LifeMap BioReagents cell lines for ADAL

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAL

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for ADAL About

See pathways by source

SuperPath

Contained pathways About

Purine metabolism

	Purine metabolism	0.42			Purine salvage	0.39
	Metabolism of nucleotides	0.42

Abacavir transport and metabolism

Abacavir transport and metabolism

0.50

Abacavir metabolism

0.50

Metabolism

Metabolism

0.40

Pathways by source See SuperPaths
Show all pathways

5/6 Reactome Pathways for ADAL (see all 6)

	Metabolism of nucleotides
	Abacavir metabolism
	Metabolism
	Purine salvage
	Purine metabolism

ADAL for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ADAL

Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006144	purine nucleobase metabolic process	TAS	--
GO:0006154	adenosine catabolic process	IBA	--
GO:0009117	nucleotide metabolic process	IEA	--
GO:0009168	purine ribonucleoside monophosphate biosynthetic process	IEA	--
GO:0017144	drug metabolic process	TAS	--

ADAL for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ADAL

Search CenterWatch for drugs/clinical trials and news about ADAL

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ADAL gene (2 alternative transcripts):

NM_001012969.2 NM_001159280.1

Unigene Cluster for ADAL:

Adenosine deaminase-like

Hs.533913 [show with all ESTs]

Unigene Representative Sequence: NM_001159280

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000428046(uc010udo.2) ENST00000389651(uc001zrh.3) ENST00000565555

ENST00000563551 ENST00000562188 ENST00000566154 ENST00000422466(uc001zri.2)

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ADAL
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate ADAL:
		hsa-miR-576-5p hsa-miR-3920 hsa-miR-29a*
		SwitchGear 3'UTR luciferase reporter plasmid: ADAL 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for ADAL
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADAL

Clone Products:		OriGene clones in human, mouse for ADAL (see all 14) OriGene ORF clones in mouse, rat for ADAL OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): ADAL (NM_001012969)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADAL
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADAL
		Sirion Biotech Customized lentivirus for stable overexpression of ADAL Customized lentivirus expression plasmids for stable overexpression of ADAL

Primer Products:		OriGene qPCR primer pairs and template standards for ADAL OriGene qSTAR qPCR primer pairs in human, mouse for ADAL
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ADAL
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADAL
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADAL

Additional mRNA sequence:

AK126583.1 AK298870.1 BC075857.1

11 DOTS entries:

DT.412202 DT.99983998 DT.99997537 DT.100683462 DT.121034813 DT.92417578 DT.100693900 DT.432612

DT.121034795 DT.95155463 DT.100705722

24/94 AceView cDNA sequences (see all 94):

BI962698 AI420327 BQ012134 AI080123 AA293426 CF529844 BX108001 BX647599

BI789209 BQ011595 AW593975 AI123939 BU737982 AA293034 BC075857 AA044810

AA284902 AA284726 BQ188219 BQ447767 BM700326 AA227487 BX108368 CK903308

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ADAL expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GAAAATCCCA

About this image

See ADAL Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ADAL

SOURCE GeneReport for Unigene cluster: Hs.533913

SABiosciences Custom PCR Arrays for ADAL

Primer Products:		OriGene qPCR primer pairs and template standards for ADAL OriGene qSTAR qPCR primer pairs in human, mouse for ADAL
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ADAL
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADAL

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAL

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for ADAL gene from 10/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Adal^{1 , 5}	adenosine deaminase-like^{1, 5}	84.36(n)¹ 83.44(a)¹		2 (60.37 cM)⁵ 75894¹ NM_029475.1¹ NP_083751.1¹ 121140428⁵
chicken (Gallus gallus)	Aves	ADAL¹	adenosine deaminase-like	74.68(n) 74.42(a)		415391 NM_001030547.1 NP_001025718.1
lizard (Anolis carolinensis)	Reptilia	ADAL⁶	Uncharacterized protein	59(a)	1 ↔ 1	GL343644.1(421-5565)
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.12484²	Transcribed sequence with weak similarity to protein more	72.72(n)		BX713295.1
zebrafish (Danio rerio)	Actinopterygii	adal¹	adenosine deaminase-like	62.94(n) 63.9(a)		619263 NM_001033744.1 NP_001028916.1
fruit fly (Drosophila melanogaster)	Insecta	Ada¹	Adenosine deaminase	46.3(n) 40.62(a)		41092 NM_141609.2 NP_649866.1
worm (Caenorhabditis elegans)	Secernentea	C44B7.12¹	Protein C44B7.12	46.49(n) 34.54(a)		259441 NM_182155.3 NP_871955.2
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	AAH1⁶	Adenine deaminase (adenine aminohydrolase), conver...	18(a)	1 → many	XIV(359596-360639)
thale cress (Arabidopsis thaliana)	eudicotyledons	AT4G04880¹	adenosine deaminase	50.22(n) 42(a)		825826 NM_116726.3 NP_192397.2
rice (Oryza sativa)	Liliopsida	Os07g0661000¹	hypothetical protein	51.21(n) 41.45(a)		4344179 NM_001067069.1 NP_001060534.1

ENSEMBL Gene Tree for ADAL (if available)
TreeFam Gene Tree for ADAL (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ADAL gene

ADAL for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for ADAL
PGOHUM00000242472

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 15 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs192090972^1,2		--	43625024(+)	`CTGCTC/TTAATA`	2	--	int¹		0	--	--	--	--
rs139155336^1,2		--	43625068(+)	`AGTGTG/TTGTTG`	2	--	int¹		0	--	--	--	--
rs142446983^1,2		--	43625074(+)	`TGTTGC/GCTTCC`	2	--	int¹		0	--	--	--	--
rs183133580^1,2		--	43625080(+)	`CTTCCA/GTCCCA`	2	--	int¹		0	--	--	--	--
rs78761824^1,2	C	--	43625218(+)	`CCATAG/TGTTAA`	2	--	int¹		0	--	--	--	--
rs187142092^1,2		--	43625342(+)	`TGGCCA/GGGCGC`	2	--	int¹		0	--	--	--	--
rs79099426^1,2	C	--	43625345(+)	`CCGGGC/TGCAGT`	2	--	int¹		0	--	--	--	--
rs113350536^1,2	C	--	43625346(+)	`CGGGCG/TCAGTG`	2	--	int¹		1		WA	2
rs139452344^1,2	C	--	43625356(+)	`GGCTCA/GCTCCT`	2	--	int¹		0	--	--	--	--
rs1123947^1,2	C,F	--	43625433(+)	`TGAGAT/CCCCGT`	2	--	int¹		6		NA WA CSA EA	132

HapMap Linkage Disequilibrium report for ADAL (43622872 - 43646096 bp)

Structural Variations
Database of Genomic Variants (DGV) 1 variation for ADAL: About this table

Variant ID	Type	Subtype	PubMed ID
nsv1512	CNV	Loss	18451855

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ADAL

DNA2.0 Custom Variant and Variant Library Synthesis for ADAL

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

3 diseases for ADAL: About MalaCards

hyperopia epididymitis tuberculosis

1 disease from the University of Copenhagen DISEASES database for ADAL:

Epididymitis

ADAL for disorders About GeneDecksing

Export disorders for ADAL gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ADAL gene integrated from 9 sources:
(articles sorted by number of sources associating them with ADAL)

Utopia: connect your pdf to the dynamic
world of online information

Mutations in adenosine deaminase-like (ADAL) protein c onfer resistance to the antiproliferative agents N6-cyclopropyl-PMEDAP and GS-92 19. (PubMed id 23645737)¹ Frey C.R....Cihlar T. (2013)
Adenosine deaminase-like protein 1 (ADAL1): character ization and substrate specificity in the hydrolysis of N(6)- or O(6)-substitute d purine or 2-aminopurine nucleoside monophosphates. (PubMed id 21755941)¹ Murakami E....Furman P.A. (2011)
Analysis of the DNA sequence and duplication history of human chromosome 15. (PubMed id 16572171)² Zody M.C....Nusbaum C. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)² Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 161823	HGNC: 31853	AceView: LOC161823	Ensembl:ENSG00000168803	euGenes: HUgn161823
ECgene: ADAL	H-InvDB: ADAL

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ADAL	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ADAL gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ADAL gene:
Search GeneIP for patents involving ADAL

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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	Browse OriGene Antibodies		OriGene RNAi products in human, mouse, rat for ADAL
	OriGene qPCR primer pairs and template standards for ADAL		OriGene Protein Over-expression Lysate for ADAL
	OriGene Custom Mass Spec		OriGene clones in human, mouse for ADAL
	OriGene qSTAR qPCR primer pairs in human, mouse for ADAL		Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
	OriGene ORF clones in mouse, rat for ADAL		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for ADAL		OriGene Custom Protein Services for ADAL

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ADAL
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ADAL
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADAL
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADAL
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADAL
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADAL

	GenScript Custom Purified and Recombinant Proteins Services for ADAL		GenScript cDNA clones with any tag delivered in your preferred vector for ADAL
	GenScript Custom Assay Services for ADAL		GenScript Custom Superior Antibodies Services for ADAL
	GenScript Custom overexpressing Cell Line Services for ADAL		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

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	Regulatory tfbs in ADAL promoter
	Search Chromatin IP Primers for ADAL
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Search Tocris compounds for ADAL

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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	ADAL antibodies
	ADAL proteins
	ADAL lysates

	Antibodies for ADAL
	See all of Abcam's Antibodies, Kits and Proteins for ADAL
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Browse ProSpec Recombinant Proteins

	Proteins for ADAL
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Search LifeMap BioReagents cell lines for ADAL

	Gene Synthesis
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	Codon Optimization
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAL

	SwitchGear 3'UTR luciferase reporter plasmids for ADAL
	SwitchGear Promoter luciferase reporter plasmids for ADAL

Search ThermoFisher Antibodies for ADAL

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADAL

	inGenious Targeting Laboratory - Custom generated mouse model solutions for ADAL
	inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ADAL

Customized:

	lentivirus for stable overexpression of ADAL
	lentivirus expression plasmids for stable overexpression of ADAL
	adenovirus for overexpression of ADAL

LSBio Antibodies in human, mouse, rat for ADAL

Customized transgenic rodents for:

	Humanization
	Biomarker expression
	Off-target effect monitoring
	Translational medicine
	Tissue-specific gene expresssion
	Time-controlled gene expresssion

GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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Category			TGFB1 (GIFtS: 73) transforming growth factor, beta 1
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes ADAL gene at Home site.

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ADAL Gene

Adenosine Deaminase-Like

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ADAL Gene

Adenosine Deaminase-Like

Aliasesfor ADAL gene

Summariesfor ADAL gene

Genomic Viewsfor ADAL gene

Proteinsfor ADAL gene

Protein Domains /Familiesfor ADAL gene

Functionfor ADAL gene

Pathways & Interactionsfor ADAL gene

Drugs & Compoundsfor ADAL gene

Transcriptsfor ADAL gene

Expression for ADAL gene

Orthologsfor ADAL gene

Paralogsfor ADAL gene

Genomic Variantsfor ADAL gene

Disorders / Diseasesfor ADAL gene

Publicationsfor ADAL gene

External Searches for ADAL gene

Genome Databases showing ADAL gene

Other Databases showing ADAL gene

Specialized Databases showing ADAL gene

Intellectual Propertyfor ADAL gene

Productsfor ADAL gene

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Aliases
for ADAL gene

Summaries
for ADAL gene

Genomic Views
for ADAL gene

Proteins
for ADAL gene

Protein Domains /
Families
for ADAL gene

Function
for ADAL gene

Pathways & Interactions
for ADAL gene

Drugs & Compounds
for ADAL gene

Transcripts
for ADAL gene

Expression
for ADAL gene

Orthologs
for ADAL gene

Paralogs
for ADAL gene

Genomic Variants
for ADAL gene

Disorders / Diseases
for ADAL gene

Publications
for ADAL gene

Intellectual Property
for ADAL gene

Products
for ADAL gene