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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ADAD2 Gene

protein-coding   GIFtS: 45
GCID: GC16P084224

Adenosine Deaminase Domain Containing 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Adenosine Deaminase Domain Containing 21 2
TENRL2 3
Adenosine Deaminase Domain-Containing Protein 22
Testis Nuclear RNA-Binding Protein-Like3

External Ids:    HGNC: 307141   Entrez Gene: 1619312   Ensembl: ENSG000001409557   UniProtKB: Q8NCV13   

Export aliases for ADAD2 gene to outside databases

Previous GC identifers: GC16P082783 GC16P069978


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ADAD2 Gene: 
ADAD2 (adenosine deaminase domain containing 2) is a protein-coding gene. Diseases associated with ADAD2 include ovarian cyst, and azoospermia. GO annotations related to this gene include double-stranded RNA binding and adenosine deaminase activity. An important paralog of this gene is ADAR.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010498.15  NC_018927.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ADAD2 gene promoter:
         STAT5B   NF-1/L   NF-1   Olf-1   MyoD   GATA-2   RORalpha1   AREB6   COMP1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidADAD2 promoter sequence
   Search SABiosciences Chromatin IP Primers for ADAD2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADAD2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q24.1   Ensembl cytogenetic band:  16q24.1   HGNC cytogenetic band: 16q24.1

ADAD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADAD2 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P084224:  view genomic region     (about GC identifiers)

Start:
84,224,723 bp from pter      End:
84,230,774 bp from pter
Size:
6,052 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ADAD2_HUMAN, Q8NCV1 (See protein sequence)
Recommended Name: Adenosine deaminase domain-containing protein 2  
Size: 583 amino acids; 61755 Da
Secondary accessions: B2RCL6 Q8NA94
Alternative splicing: 2 isoforms:  Q8NCV1-1   Q8NCV1-2   

Explore the universe of human proteins at neXtProt for ADAD2: NX_Q8NCV1

Explore proteomics data for ADAD2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8NCV1

  • ADAD2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ADAD2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001138872.1  NP_631913.3  

    ENSEMBL proteins: 
     ENSP00000268624   ENSP00000325153   ENSP00000454950  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR002466 A_deamin
     IPR001159 Ds-RNA-bd
     IPR014720 dsRNA-bd-like_dom

    Graphical View of Domain Structure for InterPro Entry Q8NCV1

    ProtoNet protein and cluster: Q8NCV1

    1 Blocks protein domain: IPB002466 Adenosine deaminase/editase

    UniProtKB/Swiss-Prot: ADAD2_HUMAN, Q8NCV1
    Similarity: Belongs to the ADAD family
    Similarity: Contains 1 A to I editase domain
    Similarity: Contains 1 DRBM (double-stranded RNA-binding) domain


    ADAD2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IEA--
    GO:0003725double-stranded RNA binding ----
    GO:0004000adenosine deaminase activity IEA--
         
    ADAD2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ADAD2:
     Increased G2M DNA content  Increased cell number in G2M,  

    Animal Models:
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAD2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ADAD2

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006396RNA processing IEA--

    ADAD2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ADAD2

    Search CenterWatch for drugs/clinical trials and news about ADAD2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ADAD2 gene (2 alternative transcripts): 
    NM_001145400.1  NM_139174.3  

    Unigene Cluster for ADAD2:

    Adenosine deaminase domain containing 2
    Hs.8977  [show with all ESTs]
    Unigene Representative Sequence: NM_139174
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000268624(uc002fhq.2 uc002fhr.2) ENST00000315906 ENST00000567413
    ENST00000567685 ENST00000566526 ENST00000564430 ENST00000569221 ENST00000564169
    ENST00000563849
    miRNA
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    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADAD2

    Additional mRNA sequence: 

    AF447586.1 AK093046.1 AK315171.1 BC033491.1 DQ323994.1 

    6 DOTS entries:

    DT.40107585  DT.97833640  DT.95218890  DT.99963576  DT.100021712  DT.99945102 

    24/35 AceView cDNA sequences (see all 35):

    BI826291 AI393108 BU731400 BM684624 AL041454 BI830969 AF447586 BM707994 
    BM931177 BQ710291 BI829308 AX748183 BI829077 BI828456 CD244636 AK131102 
    AK093046 BM908121 AK093523 NM_139174 BI829631 BC033491 AX747882 BI830941 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ADAD2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTTGTGCGG
    ADAD2 Expression
    About this image


    See ADAD2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ADAD2

    SOURCE GeneReport for Unigene cluster: Hs.8977
        SABiosciences Custom PCR Arrays for ADAD2
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAD2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ADAD2 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adad21 , 5 adenosine deaminase domain containing 21, 5 75.82(n)1
    71.1(a)1
      8 (68.05 cM)5
    757731  NM_029428.11  NP_083704.11 
     1196127475 
    lizard
    (Anolis carolinensis)
    Reptilia ADAD26
    Uncharacterized protein
    40(a)
    1 ↔ 1
    GL343635.1(201004-212202)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5588241 adenosine deaminase domain-containing protein 2-like 51.87(n)
    42.19(a)
      558824  XM_682091.4  XP_687183.1 
    worm
    (Caenorhabditis elegans)
    Secernentea D2005.16
    adr-16
    Protein ADR-1, isoform c
    23(a)
    10(a)
    many ↔ many
    many ↔ many
    I(7784498-7785624)
    I(7773416-7777577)


    ENSEMBL Gene Tree for ADAD2 (if available)
    TreeFam Gene Tree for ADAD2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ADAD2 gene
    ADAR2  ADAT12  ADARB22  ADARB12  ADAD12  
    2 SIMAP similar genes for ADAD2 using alignment to 2 protein entries:     ADAD2_HUMAN (see all proteins):
    LOC161931    FLJ00337

    ADAD2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/109 SNPs in ADAD2 are shown (see all 109)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0556504
    ----see VAR_0556502 G R mis40--------
    rs1149042181,2
    C,F--84222917(+) ATGCAG/ATAAAG 2 -- us2k11Minor allele frequency- A:0.02WA 118
    rs1382734021,2
    --84222951(+) TCATTA/GAATTT 2 -- us2k10--------
    rs1496296521,2
    --84222999(+) ATCAAC/GACAGA 2 -- us2k10--------
    rs1443839121,2
    C--84223009(+) AGAACA/GTTTCT 2 -- us2k10--------
    rs1872564011,2
    --84223020(+) ATCACC/TCAAGA 2 -- us2k10--------
    rs1410664141,2
    C--84223040(+) CCAGGC/GACAGT 2 -- us2k10--------
    rs1892274351,2
    --84223081(+) AGGCCA/GAGGTG 2 -- us2k10--------
    rs1441763111,2
    C--84223090(+) TGGGAA/GGGTTG 2 -- us2k10--------
    rs1473605991,2
    --84223132(+) CAACAC/GAGCAA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for ADAD2 (84224723 - 84230774 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for ADAD2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv457597CNV Loss19166990
    nsv907063CNV Loss21882294
    nsv907062CNV Loss21882294
    nsv523437CNV Loss19592680
    nsv833309CNV Loss17160897
    nsv518342CNV Loss19592680
    nsv907061CNV Loss21882294
    nsv907059CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for ADAD2:    About MalaCards
    ovarian cyst    azoospermia


    ADAD2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ADAD2

    Export disorders for ADAD2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ADAD2 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ADAD2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)1 Fox C.S....Borecki I.B. (2012)
    3. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    7. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
    8. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)
    9. Identification of target messenger RNA substrates for the murine deleted in azoospermia-like RNA-binding protein. (PubMed id 11804965)9 Jiao X....Kiledjian M. (2002)
    10. Embryonic lethal abnormal vision-like RNA-binding proteins regulate neurite outgrowth and tau expression in PC12 cells. (PubMed id 10436048)9 Aranda-Abreu G.E....Ginzburg I. (1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 161931 HGNC: 30714 AceView: LOC161931 Ensembl:ENSG00000140955 euGenes: HUgn161931
    ECgene: ADAD2 H-InvDB: ADAD2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ADAD2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ADAD2 gene:
    Search GeneIP for patents involving ADAD2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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