ADAD2 Gene
protein-coding GIFtS: 43
GCID: GC16P084224
|
|
adenosine deaminase domain containing 2
| |
Aliases
for ADAD2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Adenosine Deaminase Domain Containing 21 2 | | TENRL1 2 3 | | FLJ003371 | | Adenosine Deaminase Domain-Containing Protein 22 | | Testis Nuclear RNA-Binding Protein-Like3 |
Export aliases for ADAD2 gene to outside databasesPrevious GC identifers: GC16P082783 GC16P069978 |
Summaries
for ADAD2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for ADAD2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010498.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ADAD2 gene promoter:
STAT5B NF-1/L NF-1 Olf-1 MyoD GATA-2 RORalpha1 AREB6 COMP1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ADAD2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADAD2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16q24.1 Ensembl cytogenetic band: 16q24.1 HGNC cytogenetic band: 16q24.1ADAD2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16P084224: view genomic region
(about GC identifiers)
Start:
|
84,224,723 bp from pter |
End:
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84,230,774 bp from pter |
Size:
|
6,052 bases |
Orientation:
|
plus strand |
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Proteins
for ADAD2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ADAD2_HUMAN, Q8NCV1 (See
protein sequence)Recommended Name: Adenosine deaminase domain-containing protein 2 Size: 583 amino acids; 61755 Da
Secondary accessions: B2RCL6 Q8NA94Alternative splicing: 2 isoforms: Q8NCV1-1 Q8NCV1-2 Explore the universe of human proteins at neXtProt for ADAD2: NX_Q8NCV1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8NCV1
ADAD2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001138872.1 NP_631913.3
ENSEMBL proteins: ENSP00000268624 ENSP00000325153 ENSP00000454950
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005622 | intracellular |
IEA | -- |
ADAD2 for ontologies About GeneDecksing
ADAD2 Antibody Products:
Assay Products for ADAD2: |
Protein
Domains /
Families
for ADAD2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ADAD2 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8NCV1ProtoNet protein and cluster: Q8NCV1 1 Blocks protein family: IPB002466 Adenosine deaminase/editase
UniProtKB/Swiss-Prot: ADAD2_HUMAN, Q8NCV1Similarity: Belongs to the ADAD familySimilarity: Contains 1 A to I editase domainSimilarity: Contains 1 DRBM (double-stranded RNA-binding) domain |
Function
for ADAD2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADAD2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADAD2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for ADAD2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADAD2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAD2 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003725 | double-stranded RNA binding |
IEA | -- | | GO:0004000 | adenosine deaminase activity |
IEA | -- |
ADAD2 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for ADAD2:
|
Pathways & Interactions
for ADAD2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ADAD2
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006396 | RNA processing |
IEA | -- |
ADAD2 for ontologies About GeneDecksing
|
Drugs & Compounds
for ADAD2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ADAD2
Search CenterWatch for drugs/clinical trials and news about ADAD2
|
Transcripts
for ADAD2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ADAD2 gene (2 alternative transcripts): NM_001145400.1 NM_139174.3 Unigene Cluster for ADAD2: Adenosine deaminase domain containing 2 Hs.8977 [show with all ESTs]Unigene Representative Sequence: NM_1391749 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000268624(uc002fhq.2 uc002fhr.2) ENST00000315906 ENST00000567413
ENST00000567685 ENST00000566526 ENST00000564430 ENST00000569221 ENST00000564169
ENST00000563849
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADAD2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADAD2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): ADAD2 (NM_139174) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ADAD2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADAD2 |
Additional cDNA sequence: AF447586.1 AK093046.1 AK315171.1 BC033491.1 DQ323994.1 6 DOTS entries: DT.40107585 DT.97833640 DT.95218890 DT.99963576 DT.100021712 DT.99945102 24/35 AceView cDNA sequences (see all 35): BM684624 BI830969 AF447586 BI826291 BM707994 BU731400 AL041454 AI393108 BI829308 BI828456 BC033491 BI829077 BI829631 BM931177 NM_139174 BQ710291 CD244636 AX747882 BM908121 AK131102 AX748183 AK093046 AK093523 BI825685
GeneLoc Exon Structure
|
Expression
for ADAD2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ADAD2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGTTGTGCGG
About this image
See ADAD2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ADAD2
SOURCE GeneReport for Unigene cluster: Hs.8977
SABiosciences Custom PCR Arrays for ADAD2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ADAD2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ADAD2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADAD2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADAD2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAD2 |
Orthologs
for ADAD2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for ADAD2 gene from 5/14 species (see all 14) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
ADAD26 |
-- |
39(a) |
1 ↔ 1 |
GL343635.1(201004-207339) |
zebrafish
(Danio rerio) |
Actinopterygii |
LOC5588241 |
adenosine deaminase domain-containing protein 2-like |
51.87(n)
42.19(a) |
|
558824 XM_682091.4 XP_687183.1 |
worm
(Caenorhabditis elegans) |
Secernentea |
D2005.16adr-16 |
Protein D2005.1Adenosine Deaminase that acts on RNA family member... |
22(a)10(a) |
many ↔ manymany ↔ many |
I(7784493-7785619) I(7773411-7777572) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT1G017606 |
Adenosine-deaminase (editase) domain-containing pr... |
19(a) |
1 → many |
1(276266-278448) |
rice
(Oryza sativa) |
Liliopsida |
-- |
tRNA-specific adenosine deaminase 1, putative, exp... |
17(a) |
1 → many |
4(34707824-34713684) |
ENSEMBL Gene Tree for ADAD2 (if available)
TreeFam Gene Tree for ADAD2 (if available) |
Paralogs
for ADAD2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ADAD2 gene
- ADAR2 ADARB22 ADAT12 ADARB12 ADAD12
2 SIMAP similar genes for ADAD2 using alignment to 2 protein entries: ADAD2_HUMAN (see all proteins):LOC161931 FLJ00337
ADAD2 for paralogs About GeneDecksing
|
Genomic Variants
for ADAD2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ADAD2 (84224723 - 84230774 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ADAD2: -- | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for ADAD2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ADAD2 for disorders About GeneDecksing
3  diseases for ADAD2: About MalaCardsovarian cyst azoospermia neuronitis
Export disorders for ADAD2 gene to outside databases
|
Publications
for ADAD2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ADAD2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ADAD2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)1 Fox C.S....Borecki I.B. (2012)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
- Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)
- Identification of target messenger RNA substrates for the murine deleted in azoospermia-like RNA-binding protein. (PubMed id 11804965)9 Jiao X....Kiledjian M. (2002)
- Embryonic lethal abnormal vision-like RNA-binding proteins regulate neurite outgrowth and tau expression in PC12 cells. (PubMed id 10436048)9 Aranda-Abreu G.E....Ginzburg I. (1999)
|
External Searches for ADAD2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ADAD2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ADAD2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ADAD2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ADAD2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ADAD2 gene:
Search GeneIP for patents involving ADAD2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ADAD2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ADAD2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ADAD2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ADAD2 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ADAD2 | | OriGene 3'-UTR Clone for ADAD2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADAD2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADAD2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ADAD2 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ADAD2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADAD2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADAD2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADAD2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADAD2 |
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 | | | ADAD2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAD2 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADAD2 |
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