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Aliases for ADAD2 Gene

Aliases for ADAD2 Gene

  • Adenosine Deaminase Domain Containing 2 2 3
  • TENRL 3 4
  • Adenosine Deaminase Domain-Containing Protein 2 3
  • Testis Nuclear RNA-Binding Protein-Like 4

External Ids for ADAD2 Gene

Previous GeneCards Identifiers for ADAD2 Gene

  • GC16P082783
  • GC16P069978

Summaries for ADAD2 Gene

GeneCards Summary for ADAD2 Gene

ADAD2 (Adenosine Deaminase Domain Containing 2) is a Protein Coding gene. GO annotations related to this gene include RNA binding and adenosine deaminase activity. An important paralog of this gene is ADARB2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAD2 Gene

Genomics for ADAD2 Gene

Regulatory Elements for ADAD2 Gene

Genomic Location for ADAD2 Gene

Start:
84,191,117 bp from pter
End:
84,197,168 bp from pter
Size:
6,052 bases
Orientation:
Plus strand

Genomic View for ADAD2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADAD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAD2 Gene

Proteins for ADAD2 Gene

  • Protein details for ADAD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NCV1-ADAD2_HUMAN
    Recommended name:
    Adenosine deaminase domain-containing protein 2
    Protein Accession:
    Q8NCV1
    Secondary Accessions:
    • B2RCL6
    • Q8NA94

    Protein attributes for ADAD2 Gene

    Size:
    583 amino acids
    Molecular mass:
    61755 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ADAD2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADAD2 Gene

Proteomics data for ADAD2 Gene at MOPED

Post-translational modifications for ADAD2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ADAD2 Gene

Antibody Products

No data available for DME Specific Peptides for ADAD2 Gene

Domains for ADAD2 Gene

Protein Domains for ADAD2 Gene

Suggested Antigen Peptide Sequences for ADAD2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NCV1

UniProtKB/Swiss-Prot:

ADAD2_HUMAN :
  • Q8NCV1
Domain:
  • Contains 1 A to I editase domain.
  • Contains 1 DRBM (double-stranded RNA-binding) domain.
Family:
  • Belongs to the ADAD family.
genes like me logo Genes that share domains with ADAD2: view

No data available for Gene Families for ADAD2 Gene

Function for ADAD2 Gene

Gene Ontology (GO) - Molecular Function for ADAD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0004000 adenosine deaminase activity IEA --
genes like me logo Genes that share ontologies with ADAD2: view

Phenotypes for ADAD2 Gene

GenomeRNAi human phenotypes for ADAD2:
genes like me logo Genes that share phenotypes with ADAD2: view

Animal Model Products

CRISPR Products

miRNA for ADAD2 Gene

miRTarBase miRNAs that target ADAD2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADAD2

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ADAD2 Gene

Localization for ADAD2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADAD2 Gene COMPARTMENTS Subcellular localization image for ADAD2 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ADAD2 Gene

Pathways for ADAD2 Gene

SuperPathways for ADAD2 Gene

No Data Available

Interacting Proteins for ADAD2 Gene

Gene Ontology (GO) - Biological Process for ADAD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006396 RNA processing IEA --
genes like me logo Genes that share ontologies with ADAD2: view

No data available for Pathways by source for ADAD2 Gene

Transcripts for ADAD2 Gene

Unigene Clusters for ADAD2 Gene

Adenosine deaminase domain containing 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADAD2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADAD2 Gene

No ASD Table

Relevant External Links for ADAD2 Gene

GeneLoc Exon Structure for
ADAD2
ECgene alternative splicing isoforms for
ADAD2

Expression for ADAD2 Gene

mRNA expression in normal human tissues for ADAD2 Gene

mRNA differential expression in normal tissues according to GTEx for ADAD2 Gene

This gene is overexpressed in Testis (34.6).

Protein differential expression in normal tissues for ADAD2 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ADAD2 Gene

SOURCE GeneReport for Unigene cluster for ADAD2 Gene Hs.8977

genes like me logo Genes that share expressions with ADAD2: view

Expression partners for ADAD2 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ADAD2 Gene

Orthologs for ADAD2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADAD2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ADAD2 35
  • 80.3 (n)
  • 75.32 (a)
ADAD2 36
  • 72 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADAD2 35
  • 81.08 (n)
  • 75.69 (a)
ADAD2 36
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adad2 35
  • 75.82 (n)
  • 71.1 (a)
Adad2 16
Adad2 36
  • 70 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ADAD2 35
  • 98.68 (n)
  • 99.14 (a)
ADAD2 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adad2 35
  • 75.03 (n)
  • 72.29 (a)
oppossum
(Monodelphis domestica)
Mammalia ADAD2 36
  • 51 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ADAD2 36
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADAD2 36
  • 40 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia adad2 35
  • 44.56 (n)
  • 39.47 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC558824 35
  • 51.87 (n)
  • 42.19 (a)
ADAD2 36
  • 34 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea adr-1 36
  • 11 (a)
ManyToMany
D2005.1 36
  • 23 (a)
ManyToMany
Species with no ortholog for ADAD2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADAD2 Gene

ENSEMBL:
Gene Tree for ADAD2 (if available)
TreeFam:
Gene Tree for ADAD2 (if available)

Paralogs for ADAD2 Gene

Paralogs for ADAD2 Gene

Selected SIMAP similar genes for ADAD2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ADAD2: view

Variants for ADAD2 Gene

Sequence variations from dbSNP and Humsavar for ADAD2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs2303238 -- 84,195,953(+) GCCAG(C/T)GACAA synonymous-codon, reference
rs2303239 -- 84,195,974(+) TGGGC(C/T)GTGCT reference, synonymous-codon
rs2303240 -- 84,196,490(+) GCTCA(A/G)CCCCT intron-variant
rs2303241 -- 84,196,497(+) CCCTT(A/C)CTAGC intron-variant
rs2303242 -- 84,196,770(+) AAGGT(C/T)GGTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADAD2 Gene

Variant ID Type Subtype PubMed ID
nsv907059 CNV Gain 21882294
nsv833309 CNV Loss 17160897
nsv907061 CNV Loss 21882294
nsv523437 CNV Loss 19592680
nsv907062 CNV Loss 21882294
nsv907063 CNV Loss 21882294
nsv457597 CNV Loss 19166990
nsv518342 CNV Loss 19592680

Relevant External Links for ADAD2 Gene

HapMap Linkage Disequilibrium report
ADAD2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADAD2 Gene

Disorders for ADAD2 Gene

Relevant External Links for ADAD2

Genetic Association Database (GAD)
ADAD2

No disorders were found for ADAD2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for ADAD2 Gene

Publications for ADAD2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  3. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  4. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PMID: 22589738) Fox C.S. … Borecki I.B. (PLoS Genet. 2012) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for ADAD2 Gene

Sources for ADAD2 Gene

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