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ADAD2 Gene

protein-coding   GIFtS: 46
GCID: GC16P084224

Adenosine Deaminase Domain Containing 2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Adenosine Deaminase Domain Containing 21 2
TENRL2 3
Adenosine Deaminase Domain-Containing Protein 22
Testis Nuclear RNA-Binding Protein-Like3

External Ids:    HGNC: 307141   Entrez Gene: 1619312   Ensembl: ENSG000001409557   UniProtKB: Q8NCV13   

Export aliases for ADAD2 gene to outside databases

Previous GC identifers: GC16P082783 GC16P069978


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ADAD2 Gene:
ADAD2 (adenosine deaminase domain containing 2) is a protein-coding gene. GO annotations related to this gene include RNA binding and adenosine deaminase activity. An important paralog of this gene is ADAR.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NT_010498.16  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ADAD2 gene promoter:
         STAT5B   NF-1/L   NF-1   Olf-1   MyoD   GATA-2   RORalpha1   AREB6   COMP1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidADAD2 promoter sequence
   Search Chromatin IP Primers for ADAD2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ADAD2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q24.1   Ensembl cytogenetic band:  16q24.1   HGNC cytogenetic band: 16q24.1

ADAD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADAD2 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P084224:  view genomic region     (about GC identifiers)

Start:
84,224,723 bp from pter      End:
84,230,774 bp from pter
Size:
6,052 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ADAD2_HUMAN, Q8NCV1 (See protein sequence)
Recommended Name: Adenosine deaminase domain-containing protein 2  
Size: 583 amino acids; 61755 Da
Secondary accessions: B2RCL6 Q8NA94
Alternative splicing: 2 isoforms:  Q8NCV1-1   Q8NCV1-2   

Explore the universe of human proteins at neXtProt for ADAD2: NX_Q8NCV1

Explore proteomics data for ADAD2 at MOPED


See ADAD2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts): 
NP_001138872.1  NP_631913.3  

ENSEMBL proteins: 
 ENSP00000268624   ENSP00000325153   ENSP00000454950  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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2 InterPro protein domains:
 IPR002466 A_deamin
 IPR014720 dsRNA-bd_dom

Graphical View of Domain Structure for InterPro Entry Q8NCV1

ProtoNet protein and cluster: Q8NCV1

1 Blocks protein domain: IPB002466 Adenosine deaminase/editase

UniProtKB/Swiss-Prot: ADAD2_HUMAN, Q8NCV1
Similarity: Belongs to the ADAD family
Similarity: Contains 1 A to I editase domain
Similarity: Contains 1 DRBM (double-stranded RNA-binding) domain


Find genes that share domains with ADAD2           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003723RNA binding IEA--
GO:0004000adenosine deaminase activity IEA--
     
Find genes that share ontologies with ADAD2           About GenesLikeMe


Phenotypes:
     2 GenomeRNAi human phenotypes for ADAD2:
 Increased G2M DNA content  Increased cell number in G2M,  

Animal Models:
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hsa-mir-16-5p (MIRT051152), hsa-mir-18a-3p (MIRT040814)

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus3
cytosol2

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ADAD2
Interactions:

    Search GeneGlobe Interaction Network for ADAD2

STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

5 Interacting proteins for ADAD2 (ENSP000002686244) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
PSMA6ENSP000002614794STRING: ENSP00000261479
PSMA2ENSP000002233214STRING: ENSP00000223321
PSMA7ENSP000003599104STRING: ENSP00000359910
PSMA8ENSP000003111214STRING: ENSP00000311121
--ENSP000003863084STRING: ENSP00000386308
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Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006396RNA processing IEA--

Find genes that share ontologies with ADAD2           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Tocris compounds for ADAD2



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for ADAD2 gene (2 alternative transcripts): 
NM_001145400.1  NM_139174.3  

Unigene Cluster for ADAD2:

Adenosine deaminase domain containing 2
Hs.8977  [show with all ESTs]
Unigene Representative Sequence: NM_139174
9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000268624(uc002fhq.2 uc002fhr.2) ENST00000315906 ENST00000567413
ENST00000567685 ENST00000566526 ENST00000564430 ENST00000569221 ENST00000564169
ENST00000563849
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  QuantiFast Probe-based Assays in human, mouse, rat ADAD2

Additional mRNA sequence: 

AF447586.1 AK093046.1 AK315171.1 BC033491.1 DQ323994.1 

6 DOTS entries:

DT.40107585  DT.97833640  DT.95218890  DT.99963576  DT.100021712  DT.99945102 

Selected AceView cDNA sequences (see all 35):

BU731400 BM684624 BM707994 BI826291 AI393108 AL041454 AF447586 BI830969 
BI829308 BI829077 BC033491 NM_139174 AX747882 BI829631 BM931177 AK093046 
AX748183 CD244636 BQ710291 BI828456 AK093523 AK131102 BM908121 BU731201 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ADAD2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GGTTGTGCGG
ADAD2 Expression
About this image

ADAD2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

ADAD2 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.8977
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In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for ADAD2 gene from Selected species (see all 11)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Adad21 , 5 adenosine deaminase domain containing 21, 5 75.82(n)1
71.1(a)1
  8 (68.05 cM)5
757731  NM_029428.11  NP_083704.11 
 1196127475 
lizard
(Anolis carolinensis)
Reptilia ADAD26
adenosine deaminase domain containing 2
40(a)
1 ↔ 1
GL343635.1(201004-212202)
tropical clawed frog
(Xenopus tropicalis)
Amphibia adad21 adenosine deaminase domain containing 2 44.56(n)
39.47(a)
  780293  NM_001079364.1  NP_001072832.1 
zebrafish
(Danio rerio)
Actinopterygii LOC5588241 adenosine deaminase domain-containing protein 2-like 51.87(n)
42.19(a)
  558824  XM_682091.5  XP_687183.1 
worm
(Caenorhabditis elegans)
Secernentea D2005.16
adr-16
Protein ADR-1, isoform d
23(a)
11(a)
many ↔ many
many ↔ many
I(7784498-7785624) WBGene00008397
I(7773416-7777577) WBGene00000079


ENSEMBL Gene Tree for ADAD2 (if available)
TreeFam Gene Tree for ADAD2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for ADAD2 gene
ADAR2  ADAT12  ADARB22  ADARB12  ADAD12  
2 SIMAP similar genes for ADAD2 using alignment to 2 protein entries:     ADAD2_HUMAN (see all proteins):
LOC161931    FLJ00337

Find genes that share paralogs with ADAD2           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for ADAD2 (see all 109)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 16 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1149042181,2
C,F--84222917(+) ATGCAG/ATAAAG 2 -- us2k11Minor allele frequency- A:0.02WA 118
rs1382734021,2
--84222951(+) TCATTA/GAATTT 2 -- us2k10--------
rs1496296521,2
--84222999(+) ATCAAC/GACAGA 2 -- us2k10--------
rs1443839121,2
C--84223009(+) AGAACA/GTTTCT 2 -- us2k10--------
rs1872564011,2
--84223020(+) ATCACC/TCAAGA 2 -- us2k10--------
rs1410664141,2
C--84223040(+) CCAGGC/GACAGT 2 -- us2k10--------
rs1892274351,2
--84223081(+) AGGCCA/GAGGTG 2 -- us2k10--------
rs1441763111,2
C--84223090(+) TGGGAA/GGGTTG 2 -- us2k10--------
rs1473605991,2
--84223132(+) CAACAC/GAGCAA 2 -- us2k10--------
rs1180880031,2
C,F--84223241(+) TATCAC/ACACAG 2 -- us2k11Minor allele frequency- A:0.03EA 120

HapMap Linkage Disequilibrium report for ADAD2 (84224723 - 84230774 bp)

Structural Variations
     Database of Genomic Variants (DGV) 8 variations for ADAD2:    About this table    
Variant IDTypeSubtypePubMed ID
nsv457597CNV Loss19166990
nsv907063CNV Loss21882294
nsv907062CNV Loss21882294
nsv523437CNV Loss19592680
nsv833309CNV Loss17160897
nsv518342CNV Loss19592680
nsv907061CNV Loss21882294
nsv907059CNV Gain21882294

Site Specific Mutation Identification with PCR Assays
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DNA2.0 Custom Variant and Variant Library Synthesis for ADAD2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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Find genes that share disorders with ADAD2           About GenesLikeMe

Genetic Association Database (GAD): ADAD2

Export disorders for ADAD2 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for ADAD2 gene integrated from 10 sources:
(articles sorted by number of sources associating them with ADAD2)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  2. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)1 Fox C.S....Borecki I.B. (PLoS Genet. 2012)
  3. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  7. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (Genome Res. 1996)
  8. (PubMed id )2 
  9. Identification of target messenger RNA substrates for the murine deleted in azoospermia-like RNA-binding protein. (PubMed id 11804965)9 Jiao X....Kiledjian M. (Biol. Reprod. 2002)
  10. Embryonic lethal abnormal vision-like RNA-binding proteins regulate neurite outgrowth and tau expression in PC12 cells. (PubMed id 10436048)9 Aranda-Abreu G.E....Ginzburg I. (J. Neurosci. 1999)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 161931 HGNC: 30714 AceView: LOC161931 Ensembl:ENSG00000140955 euGenes: HUgn161931
ECgene: ADAD2 H-InvDB: ADAD2

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for ADAD2 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for ADAD2 gene:
Search GeneIP for patents involving ADAD2

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 OriGene ORF clones in mouse, rat for ADAD2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for ADAD2   OriGene Custom Protein Services for ADAD2  

 
 
 Block miRNA regulation of human, mouse, rat ADAD2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ADAD2
 DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ADAD2 Predesigned siRNA for gene silencing in human, mouse, rat ADAD2
 QuantiFast Probe-based Assays in human, mouse, rat ADAD2 QuantiTect SYBR Green Assays in human, mouse, rat ADAD2
 Custom PCR Arrays for ADAD2 Search Chromatin IP Primers for ADAD2
 Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ADAD2  Search GeneGlobe Interaction Network for ADAD2
 Regulatory tfbs in ADAD2 promoter
 GenScript Custom Purified and Recombinant Proteins Services for ADAD2 GenScript cDNA clones with any tag delivered in your preferred vector for ADAD2
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 CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
 Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
 Plasmid Preparation Custom Peptide Services
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 Search Tocris compounds for ADAD2
 Browse Sino Biological Proteins
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 4000+ Proteins
 Search Sino Biological for antibodies, proteins & pathways
 Protein Production Services
 Transfection Reagents
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 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

 Novus Tissue Slides
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 See all of Abcam's Antibodies, Kits and Proteins for ADAD2
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 Abcam protocols and scientific support
 Browse ProSpec Recombinant Proteins
 Proteins for ADAD2
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 Browse ESI BIO Cell Lines and PureStem Progenitors for ADAD2
 Gene Synthesis
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 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAD2
 SwitchGear 3'UTR luciferase reporter plasmids for ADAD2
 SwitchGear Promoter luciferase reporter plasmids for ADAD2
 Search ThermoFisher Antibodies for ADAD2
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADAD2
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ADAD2
 inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ADAD2
 LSBio Antibodies in human, mouse, rat for ADAD2
 Browse compounds at ApexBio
 Search Addgene for plasmids for ADAD2
  Search eBioscience for proteins for ADAD2
  Search eBioscience for elisas for ADAD2
  eBioscience FlowRNA Probe Sets
Customized transgenic rodents for:
 Humanization
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 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
 antibodies-online antibodies for ADAD2 (11 products)
 antibodies-online kits for ADAD2 (4 products)
 antibodies-online peptides for ADAD2
 antibodies-online proteins for ADAD2 (3 products)
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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