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ADAD1 Gene

protein-coding   GIFtS: 47
GCID: GC04P123300

Adenosine Deaminase Domain Containing 1 (Testis-Specific)

  Search for ADAD1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Adenosine Deaminase Domain Containing 1 (Testis-Specific)1 2
Testis Nuclear RNA-Binding Protein2 3
TENR3 5
Tenr2
Adenosine Deaminase Domain-Containing Protein 12

External Ids:    HGNC: 307131   Entrez Gene: 1326122   Ensembl: ENSG000001641137   OMIM: 6141305   UniProtKB: Q96M933   

Export aliases for ADAD1 gene to outside databases

Previous GC identifers: GC04P123519 GC04P119026


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ADAD1 Gene:
ADAD1 (adenosine deaminase domain containing 1 (testis-specific)) is a protein-coding gene. GO annotations related to this gene include RNA binding and adenosine deaminase activity. An important paralog of this gene is ADAR.

UniProtKB/Swiss-Prot: ADAD1_HUMAN, Q96M93
Function: Plays a role in spermatogenesis. Binds to RNA but not to DNA (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_016354.20  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ADAD1 gene promoter:
         HFH-3   SRF   ATF-2   SRF (504 AA)   NF-AT   FOXI1   NF-AT2   NF-AT3   c-Myb   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ADAD1 promoter sequence
   Search Chromatin IP Primers for ADAD1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ADAD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q27   Ensembl cytogenetic band:  4q27   HGNC cytogenetic band: 4q27

ADAD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADAD1 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P123300:  view genomic region     (about GC identifiers)

Start:
123,300,121 bp from pter      End:
123,350,957 bp from pter
Size:
50,837 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ADAD1_HUMAN, Q96M93 (See protein sequence)
Recommended Name: Adenosine deaminase domain-containing protein 1  
Size: 576 amino acids; 64411 Da
Secondary accessions: A6NKN4 B7WPB0 D3DNX2 Q8IWG6 Q8NA06
Alternative splicing: 3 isoforms:  Q96M93-1   Q96M93-2   Q96M93-3   

Explore the universe of human proteins at neXtProt for ADAD1: NX_Q96M93

Explore proteomics data for ADAD1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ADAD1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001152757.1  NP_001152767.1  NP_640336.1  

    ENSEMBL proteins: 
     ENSP00000390510   ENSP00000296513   ENSP00000397254   ENSP00000373376   ENSP00000373377  

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    Cloud-Clone Corp. Proteins for ADAD1

     
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    Search eBioscience for ELISAs for ADAD1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR002466 A_deamin
     IPR014720 dsRNA-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q96M93

    ProtoNet protein and cluster: Q96M93

    1 Blocks protein domain: IPB002466 Adenosine deaminase/editase

    UniProtKB/Swiss-Prot: ADAD1_HUMAN, Q96M93
    Similarity: Belongs to the ADAD family
    Similarity: Contains 1 A to I editase domain
    Similarity: Contains 1 DRBM (double-stranded RNA-binding) domain


    Find genes that share domains with ADAD1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ADAD1_HUMAN, Q96M93
    Function: Plays a role in spermatogenesis. Binds to RNA but not to DNA (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IEA--
    GO:0004000adenosine deaminase activity IEA--
         
    Find genes that share ontologies with ADAD1           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Adad1):
     reproductive system 

    Find genes that share phenotypes with ADAD1           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ADAD1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ADAD1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ADAD1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ADAD1

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    Predesigned siRNA for gene silencing in human, mouse, rat ADAD1

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ADAD1_HUMAN, Q96M93: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with ADAD1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ADAD1
    Interactions:

        Search GeneGlobe Interaction Network for ADAD1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for ADAD1 (ENSP000002965134) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PSMA6ENSP000002614794STRING: ENSP00000261479
    PSMA2ENSP000002233214STRING: ENSP00000223321
    PSMA7ENSP000003599104STRING: ENSP00000359910
    PSMA8ENSP000003111214STRING: ENSP00000311121
    ADARENSP000003574594STRING: ENSP00000357459
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006396RNA processing IEA--
    GO:0007275multicellular organismal development IEA--
    GO:0007286spermatid development IEA--

    Find genes that share ontologies with ADAD1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ADAD1

    2 Novoseek inferred chemical compound relationships for ADAD1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pyrimidine 23.5 1 9756848 (1)
    tyrosine 0 2 9202153 (1), 16996007 (1)



    Find genes that share compounds with ADAD1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ADAD1 gene (3 alternative transcripts): 
    NM_001159285.1  NM_001159295.1  NM_139243.3  

    Unigene Cluster for ADAD1:

    Adenosine deaminase domain containing 1 (testis-specific)
    Hs.518957  [show with all ESTs]
    Unigene Representative Sequence: NM_139243
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000446706 ENST00000296513(uc003ieo.3) ENST00000464160 ENST00000439307
    ENST00000388724(uc003iep.3) ENST00000388725(uc003ieq.3) ENST00000492454

    miRNA
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ADAD1
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      QuantiFast Probe-based Assays in human, mouse, rat ADAD1

    Additional mRNA sequence: 

    AK057303.1 AK093297.1 BC040229.1 

    7 DOTS entries:

    DT.40299394  DT.110002  DT.95369417  DT.100019358  DT.97785287  DT.95149417  DT.121225499 

    Selected AceView cDNA sequences (see all 71):

    AW629069 NM_139243 CD636794 BC040229 AA934788 AI968403 BP370647 AA432201 
    AW341495 CD636783 CD636788 BX111248 AW237109 CD636796 CD636792 BP370294 
    BE550296 AK057303 CD636790 AK093297 AA774419 BP370040 BG721119 BI546699 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ADAD1    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b
    SP1:                          -     -     -                                                                                                   
    SP2:                                      -                                                           -                                       
    SP3:                                            -                                                                                             
    SP4:                                                                                                                                          
    SP5:                          -     -     -                                                                                                   


    ECgene alternative splicing isoforms for ADAD1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ADAD1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAAATAGGC
    ADAD1 Expression
    About this image


    ADAD1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Testis (Reproductive System)
             XY Germ Cells Testis Cord
     
     Gonad
             XY Germ Cells Testis Cord
    ADAD1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ADAD1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.518957
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ADAD1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adad11 , 5 adenosine deaminase domain containing 1 (testis specific)1, 5 87.94(n)1
    89.22(a)1
      3 (18.30 cM)5
    217441  NM_009350.31  NP_033376.21 
     370635275 
    chicken
    (Gallus gallus)
    Aves ADAD11 adenosine deaminase domain containing 1 (testis-specific) 67.83(n)
    62.83(a)
      422669  XM_420624.4  XP_420624.3 
    lizard
    (Anolis carolinensis)
    Reptilia ADAD16
    adenosine deaminase domain containing 1 (testis-sp...
    71(a)
    1 ↔ 1
    5(138701720-138715532)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.186402 Xenopus laevis transcribed sequence with weak similarity more 76.64(n)    BU901109.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufi42e082 Transcribed sequence with weak similarity to protein more 73.22(n)    AW153833.1 
    worm
    (Caenorhabditis elegans)
    Secernentea D2005.16
    adr-16
    Protein ADR-1, isoform d
    24(a)
    12(a)
    many ↔ many
    many ↔ many
    I(7784498-7785624) WBGene00008397
    I(7773416-7777577) WBGene00000079


    ENSEMBL Gene Tree for ADAD1 (if available)
    TreeFam Gene Tree for ADAD1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ADAD1 gene
    ADAR2  ADAT12  ADARB22  ADARB12  ADAD22  

    Find genes that share paralogs with ADAD1           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for ADAD1
    PGOHUM00000238694 PGOHUM00000235056 PGOHUM00000237999


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ADAD1 (see all 1107)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1392559911,2
    --123298313(+) CATCAA/GTGTGC 1 -- us2k10--------
    rs125110651,2
    H--123298539(+) catttA/Ctagaa 1 -- us2k10--------
    rs1855941291,2
    --123298628(+) TAATCG/TATAAC 3 -- us2k10--------
    rs1896647001,2
    --123298653(+) CCCACA/CCAAAC 3 -- us2k10--------
    rs100286611,2
    C,F,H--123298789(+) cctggG/Attgca 3 -- us2k18Minor allele frequency- A:0.12NS NA WA 914
    rs1827371671,2
    C--123298865(+) AGTTAC/TGTAAG 3 -- us2k10--------
    rs1463529271,2
    C--123298878(+) ATATT-/AGGGGA 3 -- us2k10--------
    rs1417848121,2
    --123298897(+) GGAAGA/GAATGG 3 -- us2k10--------
    rs48332471,2
    C,F,H--123298910(+) agactG/Atacta 3 -- us2k118Minor allele frequency- A:0.06NS NA WA CSA EA 1489
    rs1890517671,2
    --123299101(+) CTTGAC/TATTTG 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for ADAD1 (123300121 - 123350957 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ADAD1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2673537CNV Deletion23128226
    dgv5702n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing ADAD1
    DNA2.0 Custom Variant and Variant Library Synthesis for ADAD1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614130    OMIM disorders: --


    Find genes that share disorders with ADAD1           About GenesLikeMe

    Genetic Association Database (GAD): ADAD1
    Human Genome Epidemiology (HuGE) Navigator: ADAD1 (7 documents)

    Export disorders for ADAD1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ADAD1 gene, integrated from 10 sources (see all 92):
    (articles sorted by number of sources associating them with ADAD1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. (PubMed id 21829393)1, 4 Plagnol V....Todd J.A. (PLoS Genet. 2011)
    2. Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. (PubMed id 21297633)1, 4 Anderson C.A....Rioux J.D. (Nat. Genet. 2011)
    3. Only one independent genetic association with rheumatoid arthritis within the KIAA1109-TENR-IL2-IL21 locus in Caucasian sample sets: confirmation of association of rs6822844 with rheumatoid arthritis at a genome-wide level of significance. (PubMed id 20553587)1, 4 Hollis-Moffatt J.E....Merriman T.R. (amp 2010)
    4. Genome-wide searching of rare genetic variants in WTCCC data. (PubMed id 20549515)1, 4 Feng T. and Zhu X. (Hum. Genet. 2010)
    5. Testing for the association of the KIAA1109/Tenr/IL2/IL21 gene region with rheumatoid arthritis in a European family-based study. (PubMed id 19302705)1, 4 Teixeira V.H....Petit-Teixeira E. (amp 2009)
    6. Multiple sclerosis association study with the TENR-IL2-IL21 region in a Spanish population. (PubMed id 19523143)1, 4 Fedetz M....Matesanz F. (Tissue Antigens 2009)
    7. Newly identified genetic risk variants for celiac disease related to the immune response. (PubMed id 18311140)1, 4 Hunt K.A.... van Heel D.A. (Nat. Genet. 2008)
    8. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. (PubMed id 17554300)1, 4 (Nature 2007)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. Statistical modelling and phylogenetic analysis of a deaminase domain. (PubMed id 9541871)1, 3 Mian I.S....Chatterjee A. (J. Comput. Biol. 1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 132612 HGNC: 30713 AceView: Tenr Ensembl:ENSG00000164113 euGenes: HUgn132612
    ECgene: ADAD1 H-InvDB: ADAD1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ADAD1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ADAD1 gene:
    Search GeneIP for patents involving ADAD1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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