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Aliases for ADAD1 Gene

Aliases for ADAD1 Gene

  • Adenosine Deaminase Domain Containing 1 2 3 5
  • Adenosine Deaminase Domain Containing 1 (Testis-Specific) 2 3
  • Testis Nuclear RNA-Binding Protein 3 4
  • Tenr 3 4
  • Testis Tissue Sperm-Binding Protein Li 92mP 3

External Ids for ADAD1 Gene

Previous GeneCards Identifiers for ADAD1 Gene

  • GC04P123519
  • GC04P123300
  • GC04P119026

Summaries for ADAD1 Gene

GeneCards Summary for ADAD1 Gene

ADAD1 (Adenosine Deaminase Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include RNA binding and adenosine deaminase activity. An important paralog of this gene is ADARB2.

UniProtKB/Swiss-Prot for ADAD1 Gene

  • Plays a role in spermatogenesis. Binds to RNA but not to DNA (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAD1 Gene

Genomics for ADAD1 Gene

Regulatory Elements for ADAD1 Gene

Genomic Location for ADAD1 Gene

Chromosome:
4
Start:
122,378,966 bp from pter
End:
122,429,815 bp from pter
Size:
50,850 bases
Orientation:
Plus strand

Genomic View for ADAD1 Gene

Genes around ADAD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADAD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADAD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAD1 Gene

Proteins for ADAD1 Gene

  • Protein details for ADAD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96M93-ADAD1_HUMAN
    Recommended name:
    Adenosine deaminase domain-containing protein 1
    Protein Accession:
    Q96M93
    Secondary Accessions:
    • A6NKN4
    • B7WPB0
    • D3DNX2
    • Q8IWG6
    • Q8NA06

    Protein attributes for ADAD1 Gene

    Size:
    576 amino acids
    Molecular mass:
    64411 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ADAD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADAD1 Gene

Proteomics data for ADAD1 Gene at MOPED

Post-translational modifications for ADAD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ADAD1 Gene

No data available for DME Specific Peptides for ADAD1 Gene

Domains & Families for ADAD1 Gene

Protein Domains for ADAD1 Gene

Suggested Antigen Peptide Sequences for ADAD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96M93

UniProtKB/Swiss-Prot:

ADAD1_HUMAN :
  • Contains 1 A to I editase domain.
  • Belongs to the ADAD family.
Domain:
  • Contains 1 A to I editase domain.
  • Contains 1 DRBM (double-stranded RNA-binding) domain.
Family:
  • Belongs to the ADAD family.
genes like me logo Genes that share domains with ADAD1: view

No data available for Gene Families for ADAD1 Gene

Function for ADAD1 Gene

Molecular function for ADAD1 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in spermatogenesis. Binds to RNA but not to DNA (By similarity).

Gene Ontology (GO) - Molecular Function for ADAD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
genes like me logo Genes that share ontologies with ADAD1: view
genes like me logo Genes that share phenotypes with ADAD1: view

Animal Models for ADAD1 Gene

MGI Knock Outs for ADAD1:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ADAD1 Gene

Localization for ADAD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADAD1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADAD1 Gene COMPARTMENTS Subcellular localization image for ADAD1 gene
Compartment Confidence
nucleus 4

No data available for Gene Ontology (GO) - Cellular Components for ADAD1 Gene

Pathways & Interactions for ADAD1 Gene

SuperPathways for ADAD1 Gene

No Data Available

Interacting Proteins for ADAD1 Gene

Gene Ontology (GO) - Biological Process for ADAD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006396 RNA processing IEA --
GO:0007286 spermatid development IEA --
genes like me logo Genes that share ontologies with ADAD1: view

No data available for Pathways by source and SIGNOR curated interactions for ADAD1 Gene

Drugs & Compounds for ADAD1 Gene

(1) Drugs for ADAD1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for ADAD1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ADAD1: view

Transcripts for ADAD1 Gene

Unigene Clusters for ADAD1 Gene

Adenosine deaminase domain containing 1 (testis-specific):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ADAD1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b
SP1: - - -
SP2: - -
SP3: -
SP4:
SP5: - - -

Relevant External Links for ADAD1 Gene

GeneLoc Exon Structure for
ADAD1
ECgene alternative splicing isoforms for
ADAD1

Expression for ADAD1 Gene

mRNA expression in normal human tissues for ADAD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADAD1 Gene

This gene is overexpressed in Testis (x52.6).

Protein differential expression in normal tissues from HIPED for ADAD1 Gene

This gene is overexpressed in Testis (44.6) and Bone marrow mesenchymal stem cell (20.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADAD1 Gene



SOURCE GeneReport for Unigene cluster for ADAD1 Gene Hs.518957

genes like me logo Genes that share expression patterns with ADAD1: view

Protein tissue co-expression partners for ADAD1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ADAD1 Gene

Orthologs for ADAD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADAD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADAD1 35
  • 99.71 (n)
  • 99.83 (a)
ADAD1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ADAD1 36
  • 84 (a)
OneToOne
ADAD1 35
  • 91.84 (n)
  • 91.32 (a)
dog
(Canis familiaris)
Mammalia ADAD1 35
  • 91.88 (n)
  • 92.52 (a)
ADAD1 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adad1 36
  • 83 (a)
OneToOne
Adad1 16
Adad1 35
  • 87.94 (n)
  • 89.22 (a)
oppossum
(Monodelphis domestica)
Mammalia ADAD1 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ADAD1 36
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adad1 35
  • 87.71 (n)
  • 88.35 (a)
chicken
(Gallus gallus)
Aves ADAD1 36
  • 59 (a)
OneToOne
ADAD1 35
  • 67.83 (n)
  • 62.83 (a)
lizard
(Anolis carolinensis)
Reptilia ADAD1 36
  • 71 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.18640 35
tropical clawed frog
(Silurana tropicalis)
Amphibia adad1 35
  • 67.13 (n)
  • 62.41 (a)
zebrafish
(Danio rerio)
Actinopterygii ADAD1 36
  • 47 (a)
OneToOne
adad1 35
  • 58.3 (n)
  • 53.89 (a)
wufi42e08 35
worm
(Caenorhabditis elegans)
Secernentea adr-1 36
  • 12 (a)
ManyToMany
D2005.1 36
  • 24 (a)
ManyToMany
Species with no ortholog for ADAD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADAD1 Gene

ENSEMBL:
Gene Tree for ADAD1 (if available)
TreeFam:
Gene Tree for ADAD1 (if available)

Paralogs for ADAD1 Gene

Paralogs for ADAD1 Gene

Pseudogenes.org Pseudogenes for ADAD1 Gene

genes like me logo Genes that share paralogs with ADAD1: view

Variants for ADAD1 Gene

Sequence variations from dbSNP and Humsavar for ADAD1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1383043 -- 122,421,461(-) GATAA(C/T)CATTT intron-variant
rs1383044 -- 122,421,169(-) CAAAA(C/T)ATTTC intron-variant
rs1383046 -- 122,394,115(-) AAAAA(C/G)GTACA intron-variant
rs1383047 -- 122,381,755(-) AATCA(C/T)TGGCT intron-variant
rs2127511 -- 122,391,433(-) gggca(A/G)cgcag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADAD1 Gene

Variant ID Type Subtype PubMed ID
esv2673537 CNV Deletion 23128226
dgv5702n71 CNV Loss 21882294

Variation tolerance for ADAD1 Gene

Residual Variation Intolerance Score: 20.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.53; 29.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADAD1 Gene

HapMap Linkage Disequilibrium report
ADAD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADAD1 Gene

Disorders for ADAD1 Gene

Relevant External Links for ADAD1

Genetic Association Database (GAD)
ADAD1
Human Genome Epidemiology (HuGE) Navigator
ADAD1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADAD1

No disorders were found for ADAD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADAD1 Gene

Publications for ADAD1 Gene

  1. Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. (PMID: 21829393) Plagnol V. … Todd J.A. (PLoS Genet. 2011) 3 48 67
  2. Statistical modelling and phylogenetic analysis of a deaminase domain. (PMID: 9541871) Mian I.S. … Chatterjee A. (J. Comput. Biol. 1998) 2 3
  3. Distribution of Tenr, an RNA-binding protein, in a lattice-like network within the spermatid nucleus in the mouse. (PMID: 7543294) Schumacher J.M. … Braun R.E. (Biol. Reprod. 1995) 2 3
  4. Genome-wide association study of celiac disease in North America confirms FRMD4B as new celiac locus. (PMID: 24999842) Garner C. … Neuhausen S.L. (PLoS ONE 2014) 3
  5. Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization. (PMID: 23817571) BA … . (Nat. Genet. 2013) 3

Products for ADAD1 Gene

Sources for ADAD1 Gene

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