Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ADA Gene

protein-coding GIFtS: 74
GCID: GC20M043248

adenosine deaminase

Explore 196 diseases affiliated with
ADA via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Adenosine Deaminase¹ ²
Adenosine Aminohydrolase² ³
EC 3.5.4.4³ ⁸
ADA1³

External Ids:	HGNC: 186¹	Entrez Gene: 100²	Ensembl: ENSG00000196839⁷	OMIM: 608958⁵	UniProtKB: P00813³

Export aliases for ADA gene to outside databases

Previous GC identifers: GC20M042976 GC20M043886 GC20M043933 GC20M042681 GC20M039989

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ADA:

This gene encodes an enzyme that catalyzes the hydrolysis of adenosine to inosine. Various mutations have been

described for this gene and have been linked to human diseases. Deficiency in this enzyme causes a form of severe

combined immunodeficiency disease (SCID), in which there is dysfunction of both B and T lymphocytes with impaired

cellular immunity and decreased production of immunoglobulins, whereas elevated levels of this enzyme have been

associated with congenital hemolytic anemia. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ADA_HUMAN, P00813

Function: Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine. Plays an important role in purine

metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly

to cellular signaling events. Acts as a positive regulator of T-cell coactivation, by binding DPP4. Its interaction

with DPP4 regulates lymphocyte-epithelial cell adhesion

summary for ADA:

Deaminases are enzymes that catalyze the hydrolysis of C-NH2 bonds in amino compounds, producing ammonia.

Adenosine deaminases (ADA) irreversibly convert adenosine into inosine by the removal of an amino group and

they are necessary for the breakdown of food and turnover of nucleic acids.

Gene Wiki entry for ADA (Adenosine deaminase)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000020.10 NC_018931.1 NT_011362.10

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ADA gene promoter:
AP-1 ATF-2 c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ADA promoter sequence

Search SABiosciences Chromatin IP Primers for ADA

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADA

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.12 Ensembl cytogenetic band: 20q13.12 HGNC cytogenetic band: 20q13.12

ADA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADA gene location

GeneLoc information about chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20M043248: view genomic region (about GC identifiers)

Start:	43,248,163 bp from pter	End:	43,280,874 bp from pter
Size:	32,712 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ADA_HUMAN, P00813 (See protein sequence)

Recommended Name: Adenosine deaminase

Size: 363 amino acids; 40764 Da

Cofactor: Binds 1 zinc ion per subunit

Subunit: Interacts with DPP4 (extracellular domain)

Subcellular location: Cell membrane; Peripheral membrane protein; Extracellular side. Cell junction. Cytoplasmic

vesicle lumen (By similarity). Cytoplasm (By similarity). Note=Colocalized with DPP4 at the cell junction in

lymphocyte-epithelial cell adhesion

2 PDB 3D structures from and Proteopedia for ADA:

1M7M (3D)

3IAR (3D)

Secondary accessions: Q53F92 Q6LA59

Explore the universe of human proteins at neXtProt for ADA: NX_P00813

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P00813

4/7 DME Specific Peptides for ADA (P00813) (see all 7)

SLNTDDP

QAEGDLTP

YVEVRYSPH

RSILCCMRH

ADA Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000013.2

ENSEMBL proteins:

ENSP00000361965 ENSP00000440946 ENSP00000446464 ENSP00000441818

Reactome Protein details: P00813
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for ADA (Adenosine Deaminase/ADA)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: ADA OriGene Custom Protein Services for ADA
	GenScript Custom Purified and Recombinant Proteins Services for ADA
	Novus Biologicals ADA Proteins Novus Biologicals ADA Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for ADA
	Uscn Proteins for ADA

Gene Ontology (GO): 5/12 cellular component terms (GO ID links to tree view) (see all 12): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005615	extracellular space	IEA	--
GO:0005737	cytoplasm	IDA	--
GO:0005764	lysosome	IDA	8452534
GO:0005829	cytosol	TAS	--
GO:0005886	plasma membrane	IDA	--

ADA for ontologies About GeneDecksing

ADA Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of ADA
	R&D Systems Antibodies for ADA (Adenosine Deaminase/ADA)
	OriGene Antibodies (see all 2): ADA OriGene Custom Antibody Services for ADA
	GenScript Custom Superior Antibodies Services for ADA
	Novus Biologicals ADA Antibodies
	Abcam antibodies for ADA
	Uscn Antibodies for ADA
	ThermoFisher Antibodies for ADA

Assay Products for ADA:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for ADA
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for ADA

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ADA for domains About GeneDecksing

3 InterPro domains/families:

IPR001365 A/AMP_deaminase_dom

IPR006650 A/AMP_deam_AS

IPR006330 Ado/ade_deaminase

Graphical View of Domain Structure for InterPro Entry P00813

ProtoNet protein and cluster: P00813

1 Blocks protein family: IPB006650 Adenosine/AMP deaminase active site

UniProtKB/Swiss-Prot: ADA_HUMAN, P00813

Similarity: Belongs to the adenosine and AMP deaminases family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ADA_HUMAN, P00813

Function: Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine. Plays an important role in purine

metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly

to cellular signaling events. Acts as a positive regulator of T-cell coactivation, by binding DPP4. Its interaction

with DPP4 regulates lymphocyte-epithelial cell adhesion

Catalytic activity: Adenosine + H(2)O = inosine + NH(3)

Genatlas biochemistry entry for ADA:

adenosine deaminase,adenine nucleotide catalytic pathway,including a locus control region LCR-ADA (see symbol) in

intron 1

Enzyme Number (IUBMB): EC 3.5.4.4¹ ²

miRNA Products:		OriGene 3'-UTR Clone: ADA Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ADA
		4 QIAGEN miScript miRNA Assays for microRNAs that regulate ADA:
		hsa-miR-10b* hsa-miR-29a hsa-miR-29c hsa-miR-29b
		SwitchGear 3'UTR luciferase reporter plasmid: ADA 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ADA (see all 6) OriGene siRNA: ADA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADA

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for ADA

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADA (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADA OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ADA (NM_001086)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADA
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADA

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ADA
		Search LifeMap BioReagents cell lines for ADA

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADA

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001883	purine nucleoside binding	IEA	--
GO:0004000	adenosine deaminase activity	ISS	--
GO:0005515	protein binding	IPI	14684150
GO:0008270	zinc ion binding	ISS	--
GO:0019239	deaminase activity	--	--

ADA for ontologies About GeneDecksing

3 GenomeRNAi human phenotypes for ADA:

Decreased NANOG protein expres

Decreased OCT4 protein express

Decreased POU5F1-GFP protein e

Animal Models:
Mouse knock-outs for ADA: Ada^tm1Vlr Ada^tm1Mw
12 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Ada):

cellular	growth/size	hematopoietic system	homeostasis/metabolism	immune system
liver/biliary system	mortality/aging	normal	renal/urinary system	reproductive system
respiratory system	skeleton

ADA for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Purine metabolism

	Purine metabolism	1.00			Purine salvage	0.39
	Metabolism of nucleotides	0.42

Antimetabolite Pathway - Folate Cycle, Pharmacodynamics

	Antimetabolite Pathway - Folate Cycle, Pharmacodynamics	1.00			Thiopurine Pathway, Pharmacokinetics/Pharmacodynamics	0.36
	Methotrexate Pathway (Cancer Cell), Pharmacodynamics	0.45

Metabolism

Metabolism

1.00

Metabolic pathways

0.38

adenine and adenosine salvage III

adenine and adenosine salvage III

1.00

purine ribonucleosides degradation to ribose-1-phosphate

0.75

purine nucleotides degradation II (aerobic)

purine nucleotides degradation II (aerobic)

1.00

adenosine nucleotides degradation II

0.67

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for ADA

	Transcription Ligand-dependent activation of the ESR1/SP pathway
	ATP/ITP metabolism

2 GeneGo (Thomson Reuters) Pathways for ADA

	Transcription Ligand-dependent activation of the ESR1/SP pathway
	ATP/ITP metabolism

5 BioSystems Pathways for ADA

	adenine and adenosine salvage III
	adenosine nucleotides degradation II
	C-MYB transcription factor network
	purine ribonucleosides degradation to ribose-1-phosphate
	purine nucleotides degradation II (aerobic)

4 Reactome Pathways for ADA

	Metabolism of nucleotides
	Metabolism
	Purine salvage
	Purine metabolism

3 PharmGKB Pathways for ADA

	Antimetabolite Pathway - Folate Cycle, Pharmacodynamics
	Methotrexate Pathway (Cancer Cell), Pharmacodynamics
	Thiopurine Pathway, Pharmacokinetics/Pharmacodynamics

3 Kegg Pathways (Kegg details for ADA):

	Purine metabolism
	Metabolic pathways
	Primary immunodeficiency

ADA for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for ADA

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/71 Interacting proteins for ADA (P00813³ ENSP00000361965⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 71)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ADORA2A	P29274³, ENSP00000336630⁴	I2D: score=3 STRING: ENSP00000336630
NR3C1	P04150³, ENSP00000231509⁴	I2D: score=3 STRING: ENSP00000231509
ADORA1	P30542³, ENSP00000308549⁴	I2D: score=2 STRING: ENSP00000308549
DPP4	P27487³, ENSP00000353731⁴	I2D: score=2 STRING: ENSP00000353731
NME1-NME2	P22392³	I2D: score=1

About this table

Gene Ontology (GO): 5/52 biological process terms (GO ID links to tree view) (see all 52): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001666	response to hypoxia	IDA	16670267
GO:0001701	in utero embryonic development	--	--
GO:0001821	histamine secretion	IEA	--
GO:0001829	trophectodermal cell differentiation	IEA	--
GO:0001889	liver development	IEA	--

ADA for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

ADA for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Enzo Life Sciences drugs & compounds for ADA

Compounds for ADA available from Tocris Bioscience About this table

Compound	Action	CAS #
EHNA hydrochloride	Adenosine deaminase inhibitor	[51350-19-7]
Pentostatin	Adenosine deaminase inhibitor	[53910-25-1]

7 HMDB Compounds for ADA About this table

Compound	Synonyms	CAS #	PubMed Ids
Adenosine	1-(6-amino-9H-purin-9-yl)-1-deoxy-beta-D-Ribofuranose (see all 32)	58-61-7	--
Ammonia	NH3 (see all 31)	7664-41-7	--
Deoxyadenosine	1-(6-amino-9H-purin-9-yl)-1,2-dideoxy-b-D-Ribofuranose (see all 22)	958-09-8	--
Deoxyinosine	2'-Deoxyinosine (see all 10)	890-38-0	--
Inosine	(-)-Inosine (see all 41)	58-63-9	--
Theophylline	1,3-Dimethylxanthine (see all 96)	58-55-9	--
Water	Dihydrogen oxide (see all 2)	7732-18-5	--

10/21 DrugBank Compounds for ADA (see all 21) About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Nelarabine	GW-506U78 (see all 2)	121032-29-9	enzyme	substrate	18586926 16485343 20616909 18516261 18035189 19825456
Pentostatin	2'-DCF (see all 4)	53910-25-1	target	inhibitor	2433905 11752352 10887639 17309302
1-Deaza-Adenosine	--	--	target	--	17139284 17016423 10592235
6-Hydroxy-1,6-Dihydro Purine Nucleoside	--	--	target	--	17139284 17016423 10592235
6-Hydroxy-7,8-Dihydro Purine Nucleoside	--	--	target	--	17139284 17016423 10592235
Purine Riboside	--	550-33-4	target	--	17139284 17016423 10592235
Theophylline	Dimethylxanthine (see all 6)	58-55-9	enzyme	inhibitor inducer	10718633 9203166 15467230
Vidarabine	9-beta-D-arabinofuranosyl-adenine (see all 8)	24356-66-9	enzyme	substrate	6980706 3339608 2538128
(2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-2-ol	--	--	target	--	10592235
1-((1R)-1-(HYDROXYMETHYL)-3-{6-[(3-PHENYLPROPANOYL)AMINO]-1H-INDOL-1-YL}PROPYL)-1H-IMIDAZOLE-4-CARBOXAMIDE	--	--	target	--	10592235

10/140 Novoseek chemical compound relationships for ADA gene (see all 140) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
pentostatin	91.8	162	2273300 (4), 7733907 (2), 16549110 (2), 1373528 (2) (see all 85)
inosine	88.9	111	15299191 (2), 19327339 (2), 11217148 (2), 1791825 (1) (see all 77)
coformycin	88.6	26	15043152 (2), 9223432 (2), 1747369 (1), 10766176 (1) (see all 12)
deoxyadenosine	87.8	114	8726940 (6), 2303314 (3), 1373528 (2), 15804573 (2) (see all 59)
erythro-9-(2 hydroxy 3-nonyl)adenine	87.6	75	2002459 (3), 8519602 (2), 2382828 (2), 9399998 (2) (see all 30)
purine nucleoside	86.3	100	1510925 (3), 1593902 (2), 9605997 (2), 2122593 (2) (see all 64)
purine	83.5	160	20480551 (2), 1793856 (2), 1679757 (2), 19179314 (2) (see all 94)
1-deazaadenosine	81	5	8439534 (2), 18543763 (1), 1731884 (1)
5-iodotubercidin	76.8	4	8832217 (1), 20194527 (1), 7929829 (1), 8568648 (1)
2-amino-6-chloropurine	71	2	16359173 (1)

Search CenterWatch for drugs/clinical trials and news about ADA

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ADA gene:

NM_000022.2

Unigene Cluster for ADA:

Adenosine deaminase

Hs.654536 [show with all ESTs]

Unigene Representative Sequence: BM809993

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000464097 ENST00000372874(uc002xmj.3) ENST00000536532 ENST00000492931

ENST00000539235 ENST00000537820 ENST00000545776 ENST00000536076 ENST00000535573

miRNA Products:		OriGene 3'-UTR Clone: ADA Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ADA
		4 QIAGEN miScript miRNA Assays for microRNAs that regulate ADA:
		hsa-miR-10b* hsa-miR-29a hsa-miR-29c hsa-miR-29b
		SwitchGear 3'UTR luciferase reporter plasmid: ADA 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ADA (see all 6) OriGene siRNA: ADA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADA

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADA (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADA OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ADA (NM_001086)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADA
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADA

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ADA Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ADA
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADA
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADA

Additional cDNA sequence:

AK223397.1 BC007678.2 BC040226.1 X02994.1

12 DOTS entries:

DT.100821717 DT.454795 DT.91762938 DT.100821712 DT.100821720 DT.100728740 DT.100821718 DT.100821723

DT.101982853 DT.91946218 DT.120810355 DT.120810467

24/176 AceView cDNA sequences (see all 176):

BQ002923 AL557287 BC040226 CR590997 AL832305 AA354600 CR618876 AW450871

CD365221 AK123988 CR607668 CR606425 AA938670 CN484969 CR619472 CR610127

CR615818 BX104044 BU197309 AW575869 AA309696 CB158570 T28970 BF982134

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for ADA About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13a	·	13b
SP1:
SP2:
SP3:
SP4:

ECgene alternative splicing isoforms for ADA

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ADA expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCTGGTGGCA

About this image

ADA expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 5 LifeMap Cells

Name

Category

PureStem™ progenitor T42 (Embryonic Progenitor Cell)

PureStem™ mesenchymal Progenitor SK11 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ mesenchymal progenitor SM30 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ progenitor Z1 (Embryonic Progenitor Cell)

Definitive endoderm-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ADA Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ADA

SOURCE GeneReport for Unigene cluster: Hs.654536

UniProtKB/Swiss-Prot: ADA_HUMAN, P00813

Tissue specificity: Found in all tissues, occurs in large amounts in T-lymphocytes and, at the time of weaning, in

gastrointestinal tissues

SABiosciences Expression via Pathway-Focused PCR Array including ADA:

T-cell & B-cell Activation in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ADA Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ADA
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADA
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADA

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADA

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the last universal common ancestor (LUCA).

Orthologs for ADA gene from 7/26 species (see all 26) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Ada^{1 , 5}	adenosine deaminase^{1, 5}	81.58(n)¹ 83.48(a)¹		2 (84.44 cM)⁵ 11486¹ NM_007398.3¹ NP_031424.1¹ 163726584⁵
chicken (Gallus gallus)	Aves	ADA¹	adenosine deaminase	69.25(n) 67.91(a)		419194 NM_001006290.1 NP_001006290.1
lizard (Anolis carolinensis)	Reptilia	ADA⁶	--	63(a)	1 ↔ 1	4(143983433-144014158)
zebrafish (Danio rerio)	Actinopterygii	ada¹	adenosine deaminase	64.21(n) 66.01(a)		436919 NM_001002646.1 NP_001002646.1
worm (Caenorhabditis elegans)	Secernentea	C06G3.5¹	Protein C06G3.5	49.64(n) 42.41(a)		177469 NM_068686.3 NP_501087.1
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	AAH1(YNL141W)⁴ AAH1¹	Adenine deaminase (adenine aminohydrolase), converts more⁴ Aah1p¹	41.27(n)¹ 28.57(a)¹		14(359596-360639)⁴ 855581^{1, 4} NP_014258.1^{1, 4}
E. coli (Escherichia coli)	Gamma proteobacteria	add⁶	adenosine deaminase	31(a)	possible ortholog	Chromosome(1700257-1701258)

ENSEMBL Gene Tree for ADA (if available)
TreeFam Gene Tree for ADA (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ADA gene

ADAL²

ADA for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

UniProtKB/Swiss-Prot: ADA_HUMAN, P00813

Polymorphism: There is a common allele, ADA*2, also known as the ADA 2 allozyme. It is associated with the reduced

metabolism of adenosine to inosine. It specifically enhances deep sleep and slow-wave activity (SWA) during sleep

SNP ID	Valid	Clinical significance	Chr 20 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs61737144^1,2	C,F,	non-pathogenic	39995840(+)	`AGGGCC/TACCAC`	2	V	syn¹		4		NS WA NA EU	3428
rs73598374^1,2	C,	non-pathogenic	40021723(-)	`CCTTCA/GACAAG`	2	N D	mis¹		0	--	--	--	--
rs121908715^1,2	C,F	pathogenic	39990573(-)	`CAATGC/TGGCCA`	2	A V	mis¹		1		NA	4552
rs121908718^1,2	C	pathogenic	39991285(-)	`TGACCA/CGCTCA`	2	Q P	mis¹		0	--	--	--	--
rs121908721^1,2	C	pathogenic	39991303(-)	`CTACTC/G/TGCTCA`	3	S W L	mis¹		0	--	--	--	--
rs121908738^1,2	C,	pathogenic	39992794(-)	`GAAGCC/TGGACA`	2	P L	mis¹		0	--	--	--	--
rs121908729^1,2	C	pathogenic	39993094(-)	`CAAGAC/TAGAGC`	2	T I	mis¹		0	--	--	--	--
rs121908723^1,2	C	pathogenic	39993222(-)	`ACGCCA/GGGGAG`	2	R G	mis¹		0	--	--	--	--
rs114025668^1,2	C,F,	pathogenic	39993225(+)	`CCCGGA/C/G/T GTGGA`	4	T P A S	mis¹		2		WA NA	4670
rs121908716^1,2	C	pathogenic	39993236(-)	`TCACCA/GTACTG`	2	H R	mis¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ADA (43248163 - 43280874 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for ADA
2 CNVs: 67696 35919
Human Gene Mutation Database (HGMD): ADA

Locus Specific Mutation Databases (LSDB): ADA

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ADA

DNA2.0 Custom Variant and Variant Library Synthesis for ADA

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ADA for disorders           About GeneDecksing

OMIM gene information: 608958
OMIM disorders: 102700
UniProtKB/Swiss-Prot: ADA_HUMAN, P00813

Defects in ADA are the cause of severe combined immunodeficiency autosomal recessive

T-cell-negative/B-cell-negative/NK-cell-negative due to adenosine deaminase deficiency (ADASCID) [MIM:102700]. SCID

refers to a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of

both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Patients with SCID present in

infancy with recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of

SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development. ADA-SCID is an autosomal

recessive form accounting for about 50% of non-X-linked SCIDs. ADA deficiency has been diagnosed in chronically ill

teenagers and adults (late or adult onset). Population and newborn screening programs have also identified several

healthy individuals with normal immunity who have partial ADA deficiency

20/196 diseases for ADA (see all 196): About MalaCards

severe combined immunodeficiency congenital hemolytic anemia dyschromatosis symmetrica hereditaria combined immunodeficiency

adenosine deaminase deficiency hemolytic anemia purine nucleoside phosphorylase deficiency nucleoside phosphorylase deficiency

severe combined immunodeficiency due to ada deficiency partial adenosine deaminase deficiency immunodeficiency reticular dysgenesis

giant-cell fibroblastoma anemia cauda equina syndrome pericarditis

pericardial effusion langerhans-cell histiocytosis end stage renal failure progressive multifocal leukoencephalopathy

2 diseases from the University of Copenhagen DISEASES database for ADA:

Severe combined immunodeficiency Purine nucleoside phosphorylase deficiency

10/96 Novoseek disease relationships for ADA gene (see all 96) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
adenosine deaminase deficiency	97.7	186	8879650 (3), 14612670 (3), 18020547 (3), 10202239 (2) (see all 99)
pleurisy tuberculous	92	115	18222681 (6), 19543657 (4), 12921155 (4), 19901882 (4) (see all 54)
severe combined immunodeficiency	88.8	196	10202239 (2), 8258146 (2), 9364370 (2), 1401934 (2) (see all 99)
tuberculous ascites	83.7	22	12947727 (6), 8729756 (3), 16800787 (2), 2389724 (2) (see all 9)
pericarditis tuberculous	82.2	37	11173777 (4), 8312671 (3), 12226030 (2), 17625694 (2) (see all 18)
peritonitis tuberculous	81.4	50	7698702 (5), 2219461 (4), 8938171 (4), 11466036 (3) (see all 22)
pleurisy	81.3	109	1392176 (5), 19407434 (3), 2149157 (3), 16447785 (3) (see all 43)
effusion	80.5	404	11502629 (10), 12608433 (7), 8656037 (7), 16737998 (6) (see all 99)
meningitis tuberculous	74.7	53	7837719 (5), 17333738 (3), 2028233 (3), 8935128 (3) (see all 25)
tuberculosis	72.1	196	12685967 (4), 10893921 (4), 10596453 (4), 8584540 (4) (see all 99)

Genatlas disease: ADA

SCID,autosomal recessive,immunodeficiency,severe,combined (complete ADA deficiency),associating immunodeficiency (B-T

cell CD4-lympho and thrombopenia),skeletal dysplasia,recurrent respiratory infections and asthma,hepatoplenomegaly,or

slow progressive or late onset (partial ADA deficiency)

GeneTests: ADA

Adenosine Deaminase Deficiency

Genetic Association Database (GAD): ADA
Human Genome Epidemiology (HuGE) Navigator: ADA (50 documents)

Export disorders for ADA gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ADA gene, integrated from 9 sources (see all 1414):
(articles sorted by number of sources associating them with ADA)

Utopia: connect your pdf to the dynamic
world of online information

Human adenosine deaminase. cDNA and complete primary amino acid sequence. (PubMed id 6090454)^{1, 2, 3} Daddona P.E....Orkin S.H. (1984)
Two newly identified mutations (Thr233Ile and Leu152Met) in partially adenosine deaminase-deficient (ADA-) individuals that result in differing biochemical and metabolic phenotypes. (PubMed id 9225964)^{1, 2, 9} Hirschhorn R.... Jenkins T. (1997)
Three new adenosine deaminase mutations that define a splicing enhancer and cause severe and partial phenotypes: implications for evolution of a CpG hotspot and expression of a transduced ADA cDNA. (PubMed id 8589684)^{1, 2, 9} Santisteban I....Hershfield M.S. (1995)
Regulation of epithelial and lymphocyte cell adhesion by adenosine deaminase-CD26 interaction. (PubMed id 11772392)^{1, 2, 9} Gines S....Franco R. (2002)
Direct association of adenosine deaminase with a T cell activation antigen, CD26. (PubMed id 8101391)^{1, 2, 9} Kameoka J.... Morimoto C. (1993)
The role of adenosine-related genes variants in susceptibility to essential hypertension. (PubMed id 15257174)^{1, 4, 9} Wright K....Griffiths L.R. (2004)
A functional genetic variation of adenosine deaminase affects the duration and intensity of deep sleep in humans. (PubMed id 16221767)^{1, 2, 9} Retey J.V.... Landolt H.-P. (2005)
Adenosine deaminase alleles and autistic disorder: case-control and family-based association studies. (PubMed id 11121182)^{1, 4, 9} Persico A.M....Keller F. (2000)
Four new adenosine deaminase mutations, altering a zinc-binding histidine, two conserved alanines, and a 5' splice site. (PubMed id 7599635)^{1, 2, 9} Santisteban I.... Hershfield M.S. (1995)
Homozygosity for a missense mutation (G20R) associated with neonatal onset adenosine deaminase-deficient severe combined immunodeficiency (ADA-SCID). (PubMed id 8299233)^{1, 2, 9} Yang D.R.... Hirschhorn R. (1994)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 100	HGNC: 186	AceView: ADA	Ensembl:ENSG00000196839	euGenes: HUgn100
ECgene: ADA	Kegg: 100	H-InvDB: ADA

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ADA	Pharmacogenomics, SNPs, Pathways
ADAbase	http://bioinf.uta.fi/ADAbase/
GeneReviews	http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/ADA
Wikipedia	http://en.wikipedia.org/wiki/Adenosine_deaminase

Intellectual Property for ADA gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ADA gene:
Search GeneIP for patents involving ADA

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section

	Browse Kits and Assays available from EMD Millipore
	Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
	EMD Millipore Mono- and Polyclonal Antibodies for the study of ADA
	Browse for Gene Knock-down Tools from EMD Millipore
	Browse Small Molecules at EMD Millipore
	Browse Purified and Recombinant Proteins at EMD Millipore

	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Antibodies for ADA (Adenosine Deaminase/ADA)		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Recombinant/Natural Proteins for ADA (Adenosine Deaminase/ADA)

	OriGene Antibodies for ADA		Browse OriGene shRNA RFPs
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ADA		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ADA
	OriGene Protein Over-expression Lysate for ADA		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for ADA		OriGene 3'-UTR Clone for ADA
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADA		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADA
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for ADA		OriGene Custom Protein Services for ADA
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ADA
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ADA
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADA
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADA
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADA
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADA

	GenScript Custom Purified and Recombinant Proteins Services for ADA		GenScript cDNA clones with any tag delivered in your preferred vector for ADA
	GenScript Custom Assay Services for ADA		GenScript Custom Superior Antibodies Services for ADA
	GenScript Custom overexpressing Cell Line Services for ADA		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in ADA promoter
	Search Chromatin IP Primers for ADA
	RT² qPCR Primer Assay in human, mouse, rat ADA
	GNC Network for ADA
	SABiosciences PCR Arrays including human, mouse, rat ADA

Tocris compounds for ADA

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

	Drugs for ADA
	Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	ADA antibodies
	ADA proteins
	ADA lysates

	Antibodies for ADA
	See all of Abcam's Antibodies, Kits and Proteins for ADA
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Recombinant Protein for ADA

ADA Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for ADA

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADA

	SwitchGear 3'UTR luciferase reporter plasmids for ADA
	SwitchGear Promoter luciferase reporter plasmids for ADA

ThermoFisher Antibodies for ADA

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADA

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes ADA gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

ADA Gene

adenosine deaminase

Aliases
for ADA gene

Summaries
for ADA gene

Genomic Views
for ADA gene

Proteins
for ADA gene

Protein Domains /
Families
for ADA gene

Function
for ADA gene

Pathways & Interactions
for ADA gene

Drugs & Compounds
for ADA gene

Transcripts
for ADA gene

Expression
for ADA gene

Orthologs
for ADA gene

Paralogs
for ADA gene

Genomic Variants
for ADA gene

Disorders / Diseases
for ADA gene

Publications
for ADA gene

External Searches for ADA gene

Genome Databases showing ADA gene

Other Databases showing ADA gene

Specialized Databases showing ADA gene

Intellectual Property
for ADA gene

Products
for ADA gene

View Random Gene

purine metabolism disorder
Leukemia B-Cell
Pleurisy
Leukemia T-Cell
Anemia Hemolytic
Pericardial Effusion
Waldenstrom Macroglobulinemia
Lymphoma T-Cell
Xeroderma Pigmentosum
dysplasia
allergy
insulin sensitivity
reticular dysgenesis
Meningitis Tuberculous
Meningitis Viral
Achlorhydria
Intoxication
Acute pericarditis
Breast Cancer
Empyema
AIDS
Adenocarcinoma
Mycosis Fungoides
OMENN SYNDROME
Peritonitis Tuberculous
malignant ascites
Encephalitis Viral
Lymphoma
Meningitis
Granulomatous Disease Chronic
effusion
Tuberculous ascites
Tuberculosis
Leukemia Hairy Cell
Cysts
immunodeficiency
Sarcoidosis
Rheumatoid Arthritis
Tumors
Lymphoblastic Leukemia Acute
Liver Cirrhosis
Sarcoma
metabolic disorder
Lymphoma T-Cell Cutaneous
Pericarditis Constrictive
ENZYME DEFICIENCY
lymphoid neoplasm
indolent lymphoma
Melanoma
BREAST CARCINOMA
Brain Tumors
Tuberculosis Pulmonary
Leukemia Lymphocytic Chronic
Meningitis Bacterial
Meningitis Cryptococcal
Pericarditis Tuberculous
B-ALL
Meningitis Aseptic
Myeloid Leukemia Chronic
Leukemia
Severe Combined Immunodeficiency
Blast Crisis
Empyema Tuberculous
SEVERE COMBINED IMMUNODEFICIENCY, X-LINKED
Lymphopenia
Hematologic Malignancies
rare disease
Gaucher Disease
Varicella
Influenza
Type 1 Gaucher Disease
Pleural Effusion Malignant
Pericarditis
ivdu
HIV Infections
Ascites
Tuberculosis Miliary
T-ALL
DYSCHROMATOSIS SYMMETRICA HEREDITARIA
BEHCET DISEASE
mesothelioma
Pneumonia Bacterial
Leukemia Prolymphocytic
Carcinomatosis
Granuloma
Pleurisy Tuberculous
Lymphoma Non-Hodgkins
genetic disorder
extrapulmonary tuberculosis
Peritonitis
adenosine deaminase deficiency
Hypercholesterolemia Familial
Pleural Diseases
LEUKAEMIA LYMPHOCYTIC
Lupus Erythematosus Systemic
Renal Failure Chronic

Advanced Search

Export list of displayed genes

ADA Gene

adenosine deaminase

Aliasesfor ADA gene

Summariesfor ADA gene

Genomic Viewsfor ADA gene

Proteinsfor ADA gene

Protein Domains /Familiesfor ADA gene

Functionfor ADA gene

Pathways & Interactionsfor ADA gene

Drugs & Compoundsfor ADA gene

Transcriptsfor ADA gene

Expression for ADA gene

Orthologsfor ADA gene

Paralogsfor ADA gene

Genomic Variantsfor ADA gene

Disorders / Diseasesfor ADA gene

Publicationsfor ADA gene

External Searches for ADA gene

Genome Databases showing ADA gene

Other Databases showing ADA gene

Specialized Databases showing ADA gene

Intellectual Propertyfor ADA gene

Productsfor ADA gene

View Random Gene

Aliases
for ADA gene

Summaries
for ADA gene

Genomic Views
for ADA gene

Proteins
for ADA gene

Protein Domains /
Families
for ADA gene

Function
for ADA gene

Pathways & Interactions
for ADA gene

Drugs & Compounds
for ADA gene

Transcripts
for ADA gene

Expression
for ADA gene

Orthologs
for ADA gene

Paralogs
for ADA gene

Genomic Variants
for ADA gene

Disorders / Diseases
for ADA gene

Publications
for ADA gene

Intellectual Property
for ADA gene

Products
for ADA gene