Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



ADA Gene

protein-coding   GIFtS: 78
GCID: GC20M043248

Adenosine Deaminase

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Adenosine Deaminase1 2
Adenosine Aminohydrolase2 3
EC 3.5.4.43 8
ADA13

External Ids:    HGNC: 1861   Entrez Gene: 1002   Ensembl: ENSG000001968397   OMIM: 6089585   UniProtKB: P008133   
ORGUL members:         

Export aliases for ADA gene to outside databases

Previous GC identifers: GC20M042976 GC20M043886 GC20M043933 GC20M042681 GC20M039989


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for ADA Gene:
This gene encodes an enzyme that catalyzes the hydrolysis of adenosine to inosine. Various mutations have been
described for this gene and have been linked to human diseases. Deficiency in this enzyme causes a form of severe
combined immunodeficiency disease (SCID), in which there is dysfunction of both B and T lymphocytes with impaired
cellular immunity and decreased production of immunoglobulins, whereas elevated levels of this enzyme have been
associated with congenital hemolytic anemia. (provided by RefSeq, Jul 2008)

GeneCards Summary for ADA Gene:
ADA (adenosine deaminase) is a protein-coding gene. Diseases associated with ADA include peritonitis, and miliary tuberculosis. GO annotations related to this gene include purine nucleoside binding and adenosine deaminase activity.

UniProtKB/Swiss-Prot: ADA_HUMAN, P00813
Function: Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine. Plays an important role in
purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so
contributes indirectly to cellular signaling events. Acts as a positive regulator of T-cell coactivation, by
binding DPP4. Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion

summary for ADA Gene:
Deaminases are enzymes that catalyze the hydrolysis of C-NH2 bonds in amino compounds, producing ammonia.
Adenosine deaminases (ADA) irreversibly convert adenosine into inosine by the removal of an amino group and
they are necessary for the breakdown of food and turnover of nucleic acids.

Gene Wiki entry for ADA (Adenosine deaminase) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000020.11  NT_011362.11  NC_018931.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ADA gene promoter:
         AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidADA promoter sequence
   Search Chromatin IP Primers for ADA

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ADA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.12   Ensembl cytogenetic band:  20q13.12   HGNC cytogenetic band: 20q13.12

ADA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADA gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M043248:  view genomic region     (about GC identifiers)

Start:
43,248,163 bp from pter      End:
43,280,874 bp from pter
Size:
32,712 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: ADA_HUMAN, P00813 (See protein sequence)
Recommended Name: Adenosine deaminase  
Size: 363 amino acids; 40764 Da
Cofactor: Binds 1 zinc ion per subunit
Subunit: Interacts with DPP4 (extracellular domain)
2 PDB 3D structures from and Proteopedia for ADA:
1M7M (3D)        3IAR (3D)    
Secondary accessions: Q53F92 Q6LA59

Explore the universe of human proteins at neXtProt for ADA: NX_P00813

Explore proteomics data for ADA at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys23, Lys54, Lys92, Lys111, Lys147, Lys164, Lys171, Lys206, Lys225, Lys232,
                                 Lys273, Lys284, Lys301, Lys312, Lys323, Lys331, Lys340
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for ADA (P00813) (see all 7)
     SLNTDDP  QAEGDLTP  YVEVRYSPH  RSILCCMRH 


    See ADA Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000013.2  
    ENSEMBL proteins: 
     ENSP00000361965   ENSP00000440946   ENSP00000446464   ENSP00000441818  
    Reactome Protein details: P00813

    ADA Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for ADA (Adenosine Deaminase/ADA)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for ADA
    OriGene Custom MassSpec
    OriGene Custom Protein Services for ADA
    GenScript Custom Purified and Recombinant Proteins Services for ADA
    Novus Biologicals ADA Proteins
    Novus Biologicals ADA Lysates
    Sino Biological Recombinant Protein for ADA
    Sino Biological Cell Lysate for ADA
    ProSpec Recombinant Protein for ADA
    Cloud-Clone Corp. Proteins for ADA

    ADA Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of ADA
    R&D Systems Antibodies for ADA (Adenosine Deaminase/ADA)
    OriGene Antibodies for ADA
    OriGene Custom Antibody Services for ADA
    Novus Biologicals ADA Antibodies
    Abcam antibodies for ADA
    Cloud-Clone Corp. Antibodies for ADA
    ThermoFisher Antibody for ADA
    LSBio Antibodies in human, mouse, rat for ADA

    ADA Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ADA
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ADA
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ADA
    Cloud-Clone Corp. CLIAs for ADA


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    IUPHAR Guide to PHARMACOLOGY protein family classification: Adenosine deaminase
    Adenosine turnover

    4 InterPro protein domains:
     IPR001365 A/AMP_deaminase_dom
     IPR028893 A_deaminase
     IPR006650 A/AMP_deam_AS
     IPR006330 Ado/ade_deaminase

    Graphical View of Domain Structure for InterPro Entry P00813

    ProtoNet protein and cluster: P00813

    1 Blocks protein domain: IPB006650 Adenosine/AMP deaminase active site

    UniProtKB/Swiss-Prot: ADA_HUMAN, P00813
    Similarity: Belongs to the adenosine and AMP deaminases family


    ADA for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ADA_HUMAN, P00813
    Function: Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine. Plays an important role in
    purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so
    contributes indirectly to cellular signaling events. Acts as a positive regulator of T-cell coactivation, by
    binding DPP4. Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion
    Catalytic activity: Adenosine + H(2)O = inosine + NH(3)

         Genatlas biochemistry entry for ADA:
    adenosine deaminase,adenine nucleotide catalytic pathway,including a locus control region LCR-ADA (see symbol) in
    intron 1

         Enzyme Number (IUBMB): EC 3.5.4.41 2

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001883purine nucleoside binding IEA--
    GO:0004000adenosine deaminase activity ISS--
    GO:0005515protein binding IPI14684150
    GO:0008270zinc ion binding ISS--
    GO:0019239deaminase activity ----
         
    ADA for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for ADA:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e 

         12 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ada):
     cellular  growth/size/body  hematopoietic system  homeostasis/metabolism  immune system 
     liver/biliary system  mortality/aging  normal  renal/urinary system  reproductive system 
     respiratory system  skeleton 

    ADA for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for ADA: Adatm1Vlr Adatm1Mw

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ADA
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ADA

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ADA
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ADA

    miRNA
    Products:
        
    miRTarBase miRNAs that target ADA:
    hsa-mir-484 (MIRT041891), hsa-mir-98-5p (MIRT027685)

    Block miRNA regulation of human, mouse, rat ADA using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate ADA:
    hsa-miR-10b* hsa-miR-29a hsa-miR-29c hsa-miR-29b
    SwitchGear 3'UTR luciferase reporter plasmidADA 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ADA
    Predesigned siRNA for gene silencing in human, mouse, rat ADA

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ADA

    Clone
    Products:
         
    OriGene clones in human, mouse for ADA (see all 7)
    OriGene ORF clones in mouse, rat for ADA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ADA (NM_001086)
    Sino Biological Human cDNA Clone for ADA
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADA

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ADA
    Browse ESI BIO Cell Lines and PureStem Progenitors for ADA 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADA


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    ADA_HUMAN, P00813: Cell membrane; Peripheral membrane protein; Extracellular side. Cell junction. Cytoplasmic
    vesicle lumen (By similarity). Cytoplasm (By similarity). Note=Colocalized with DPP4 at the cell junction in
    lymphocyte-epithelial cell adhesion
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    lysosome5
    plasma membrane5
    vacuole5
    cytosol4
    extracellular3
    mitochondrion2
    nucleus2
    peroxisome2

    Gene Ontology (GO): Selected cellular component terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--
    GO:0005737cytoplasm IDA--
    GO:0005764lysosome IDA8452534
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane IDA--

    ADA for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for ADA About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Purine metabolism (REACTOME)
    Purine metabolism0.42
    purine nucleotides degradation0.00
    Metabolism of nucleotides0.42
    purine ribonucleosides degradation to ribose-1-phosphate0.00
    purine deoxyribonucleosides degradation0.00
    Purine salvage0.00
    adenine and adenosine salvage III0.00
    adenosine nucleotides degradation0.00
    2Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    3Purine metabolism (KEGG)
    Purine metabolism0.38
    ATP ITP metabolism0.31
    4One carbon pool by folate
    Methotrexate Pathway (Cancer Cell), Pharmacodynamics0.35
    Antimetabolite Pathway - Folate Cycle, Pharmacodynamics0.00
    Thiopurine Pathway, Pharmacokinetics/Pharmacodynamics0.34
    5purine nucleotide salvage
    purine nucleotide salvage0.78

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 GeneGo (Thomson Reuters) Pathways for ADA
        Transcription Ligand-dependent activation of the ESR1/SP pathway
    ATP/ITP metabolism

    Selected BioSystems Pathways for ADA (see all 7)
        adenine and adenosine salvage III
    purine nucleotide salvage
    C-MYB transcription factor network
    adenosine nucleotides degradation
    purine nucleotides degradation


    1 Reactome Pathway for ADA
        Purine salvage

    3 PharmGKB Pathways for ADA
        Antimetabolite Pathway - Folate Cycle, Pharmacodynamics
    Methotrexate Pathway (Cancer Cell), Pharmacodynamics
    Thiopurine Pathway, Pharmacokinetics/Pharmacodynamics

    3 Kegg Pathways  (Kegg details for ADA):
        Purine metabolism
    Metabolic pathways
    Primary immunodeficiency


    ADA for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including ADA: 
              T-cell & B-cell Activation in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ADA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ADA (P008133 ENSP000003619654) via UniProtKB, MINT, STRING, and/or I2D (see all 81)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADORA2AP292743, ENSP000003366304I2D: score=3 STRING: ENSP00000336630
    NR3C1P041503, ENSP000002315094I2D: score=3 STRING: ENSP00000231509
    ADORA1P305423, ENSP000003085494I2D: score=2 STRING: ENSP00000308549
    DPP4P274873, ENSP000003537314I2D: score=2 STRING: ENSP00000353731
    NME1-NME2P223923I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 53):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001666response to hypoxia IDA16670267
    GO:0001701in utero embryonic development ----
    GO:0001821histamine secretion IEA--
    GO:0001829trophectodermal cell differentiation IEA--
    GO:0001889liver development IEA--

    ADA for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for ADA
      Browse compounds at ApexBio 

    Compounds for ADA available from Tocris Bioscience    About this table
    CompoundAction CAS #
    PentostatinAdenosine deaminase inhibitor[53910-25-1]
    1-DeazaadenosineAdenosine deaminase inhibitor[14432-09-8]

    7 HMDB Compounds for ADA    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine1-(6-amino-9H-purin-9-yl)-1-deoxy-beta-D-Ribofuranose (see all 32)58-61-7--
    AmmoniaNH3 (see all 31)7664-41-7--
    Deoxyadenosine1-(6-amino-9H-purin-9-yl)-1,2-dideoxy-b-D-Ribofuranose (see all 22)958-09-8--
    Deoxyinosine2'-Deoxyinosine (see all 10)890-38-0--
    Inosine(-)-Inosine (see all 41)58-63-9--
    Theophylline1,3-Dimethylxanthine (see all 96)58-55-9--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    Selected DrugBank Compounds for ADA (see all 21)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    NelarabineGW-506U78 (see all 2)121032-29-9enzymesubstrate18586926 16485343 20616909 18516261 18035189 19825456
    Pentostatin2'-DCF (see all 4)53910-25-1targetinhibitor2433905 11752352 10887639 17309302
    1-Deaza-Adenosine-- --target--17139284 17016423 10592235
    6-Hydroxy-1,6-Dihydro Purine Nucleoside-- --target--17139284 17016423 10592235
    6-Hydroxy-7,8-Dihydro Purine Nucleoside-- --target--17139284 17016423 10592235
    Purine Riboside-- 550-33-4target--17139284 17016423 10592235
    TheophyllineDimethylxanthine (see all 6)58-55-9enzymeinhibitor inducer10718633 9203166 15467230
    Vidarabine9-beta-D-arabinofuranosyl-adenine (see all 8)24356-66-9enzymesubstrate6980706 3339608 2538128
    (2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-2-ol-- --target--10592235
    1-((1R)-1-(HYDROXYMETHYL)-3-{6-[(3-PHENYLPROPANOYL)AMINO]-1H-INDOL-1-YL}PROPYL)-1H-IMIDAZOLE-4-CARBOXAMIDE-- --target--10592235

    2 IUPHAR Ligands for ADA (Adenosine deaminase)    About this table
    LigandTypeActionAffinityPubmed IDs
    pentostatin
    InhibitorInhibition10.8849330
    EHNA
    InhibitorInhibition8.8849330

    Selected Novoseek inferred chemical compound relationships for ADA gene (see all 140)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pentostatin 91.8 162 2273300 (4), 7733907 (2), 16549110 (2), 1373528 (2) (see all 85)
    inosine 88.9 111 15299191 (2), 19327339 (2), 11217148 (2), 1791825 (1) (see all 77)
    coformycin 88.6 26 15043152 (2), 9223432 (2), 1747369 (1), 10766176 (1) (see all 12)
    deoxyadenosine 87.8 114 8726940 (6), 2303314 (3), 1373528 (2), 15804573 (2) (see all 59)
    erythro-9-(2 hydroxy 3-nonyl)adenine 87.6 75 2002459 (3), 8519602 (2), 2382828 (2), 9399998 (2) (see all 30)
    purine nucleoside 86.3 100 1510925 (3), 1593902 (2), 9605997 (2), 2122593 (2) (see all 64)
    purine 83.5 160 20480551 (2), 1793856 (2), 1679757 (2), 19179314 (2) (see all 94)
    1-deazaadenosine 81 5 8439534 (2), 18543763 (1), 1731884 (1)
    5-iodotubercidin 76.8 4 8832217 (1), 20194527 (1), 7929829 (1), 8568648 (1)
    2-amino-6-chloropurine 71 2 16359173 (1)



    ADA for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for ADA gene: 
    NM_000022.2  

    Unigene Cluster for ADA:

    Adenosine deaminase
    Hs.654536  [show with all ESTs]
    Unigene Representative Sequence: BM809993
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000464097 ENST00000372874(uc002xmj.3) ENST00000536532 ENST00000492931
    ENST00000539235 ENST00000537820 ENST00000545776 ENST00000536076 ENST00000535573

    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ADA using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate ADA:
    hsa-miR-10b* hsa-miR-29a hsa-miR-29c hsa-miR-29b
    SwitchGear 3'UTR luciferase reporter plasmidADA 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ADA
    Predesigned siRNA for gene silencing in human, mouse, rat ADA
    Clone
    Products:
         
    OriGene clones in human, mouse for ADA (see all 7)
    OriGene ORF clones in mouse, rat for ADA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ADA (NM_001086)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADA
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ADA
    OriGene qSTAR qPCR primer pairs in human, mouse for ADA
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ADA
      QuantiTect SYBR Green Assays in human, mouse, rat ADA
      QuantiFast Probe-based Assays in human, mouse, rat ADA

    Additional mRNA sequence: 

    AK223397.1 BC007678.2 BC040226.1 X02994.1 

    12 DOTS entries:

    DT.100821717  DT.454795  DT.100821712  DT.91762938  DT.100821720  DT.100728740  DT.100821718  DT.100821723 
    DT.101982853  DT.91946218  DT.120810355  DT.120810467 

    Selected AceView cDNA sequences (see all 176):

    AK123988 BU197309 BM463492 CN484969 CR612145 AA309696 CR615818 CR590997 
    CR622953 CR609012 CR622485 CR607668 BQ002923 BQ772534 CR609053 CR623349 
    CR606425 BC007678 CD365221 BX104044 CR621286 T28970 AL832305 CB158570 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ADA    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b
    SP1:                                                                                    
    SP2:                                                                                    
    SP3:                                                                                    
    SP4:                                                                                    


    ECgene alternative splicing isoforms for ADA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    ADA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTGGTGGCA
    ADA Expression
    About this image


    ADA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 4 entries
             Plasmacytoid Dendritic cells Peripheral Blood
             ADA-transduced hematopoietic stem cells
             ADAtransduced hematopoietic stem cells
     
     Paraxial Mesoderm (Gastrulation Derivatives)
             PureStem SK11, NCr-fac & Meso-prx Progenitor
     
     Neural Crest (Gastrulation Derivatives)
             PureStem SK11, NCr-fac & Meso-prx Progenitor
     
     Heart (Cardiovascular System)
             Atrioventricular Canal Cells Atrioventricular Canal
     
     Brain (Nervous System)
             Myelinating Oligodendrocyte Cells Forebrain White Matter
    ADA Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ADA Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654536

    UniProtKB/Swiss-Prot: ADA_HUMAN, P00813
    Tissue specificity: Found in all tissues, occurs in large amounts in T-lymphocytes and, at the time of weaning, in
    gastrointestinal tissues

        Pathway & Disease-focused RT2 Profiler PCR Array including ADA: 
              T-cell & B-cell Activation in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ADA
    OriGene qSTAR qPCR primer pairs in human, mouse for ADA
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ADA
    QuantiTect SYBR Green Assays in human, mouse, rat ADA
    QuantiFast Probe-based Assays in human, mouse, rat ADA
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADA

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ADA gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ada1 , 5 adenosine deaminase1, 5 81.58(n)1
    83.48(a)1
      2 (84.44 cM)5
    114861  NM_001272052.11  NP_001258981.11 
     1637265845 
    chicken
    (Gallus gallus)
    Aves ADA1 adenosine deaminase 69.24(n)
    67.71(a)
      419194  NM_001006290.2  NP_001006290.1 
    lizard
    (Anolis carolinensis)
    Reptilia ADA6
    adenosine deaminase
    64(a)
    1 ↔ 1
    4(143967066-144014656)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ada1 adenosine deaminase 66.48(n)
    72(a)
      496434  NM_001011025.1  NP_001011025.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ada1 adenosine deaminase 63.87(n)
    65.55(a)
      436919  NM_001002646.1  NP_001002646.1 
    worm
    (Caenorhabditis elegans)
    Secernentea C06G3.51 C06G3.5 49.5(n)
    42.17(a)
      177469  NM_068686.4  NP_501087.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes AAH1(YNL141W)4
    AAH11
    Adenine deaminase (adenine aminohydrolase), converts more4
    AAH11
    41.27(n)1
    28.57(a)1
      14(359596-360639)4
    8555811, 4  NP_014258.11, 4 


    ENSEMBL Gene Tree for ADA (if available)
    TreeFam Gene Tree for ADA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Polymorphic Variants from UniProtKB/Swiss-Prot
    ADA_HUMAN, P00813: There is a common allele, ADA*2, also known as the ADA 2 allozyme. It is associated with the reduced
    metabolism of adenosine to inosine. It specifically enhances deep sleep and slow-wave activity (SWA) during sleep


    Selected SNPs for ADA (see all 894)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1219087151,2,,4
    C,FSevere combined immunodeficiency autosomal recessive T-cell-negative/B-cell-negative/NK-cell-negative due to adenosine deaminase deficiency (ADASCID)4 pathogenic143219761(-) CAATGC/TGGCCA 2 A V mis11Minor allele frequency- T:0.00NA 4552
    rs1219087181,2,,4
    CSevere combined immunodeficiency autosomal recessive T-cell-negative/B-cell-negative/NK-cell-negative due to adenosine deaminase deficiency (ADASCID)4 pathogenic143220473(-) TGACCA/CGCTCA 2 Q P mis10--------
    rs1219087211,2,,4
    CSevere combined immunodeficiency autosomal recessive T-cell-negative/B-cell-negative/NK-cell-negative due to adenosine deaminase deficiency (ADASCID)4 pathogenic143220491(-) CTACTC/G/TGCTCA 3 S W L mis10--------
    rs1219087381,2,,4
    CSevere combined immunodeficiency autosomal recessive T-cell-negative/B-cell-negative/NK-cell-negative due to adenosine deaminase deficiency (ADASCID)4 pathogenic143221982(-) GAAGCC/TGGACA 2 P L mis10--------
    rs1219087231,2,,4
    CSevere combined immunodeficiency autosomal recessive T-cell-negative/B-cell-negative/NK-cell-negative due to adenosine deaminase deficiency (ADASCID)4 pathogenic143222409(-) ACGCCA/GGGGAG 2 R G mis10--------
    rs1140256681,2,,4
    C,FSevere combined immunodeficiency autosomal recessive T-cell-negative/B-cell-negative/NK-cell-negative due to adenosine deaminase deficiency (ADASCID)4 pathogenic143222412(+) CCCGGC/TGTGGA 2 T A mis12Minor allele frequency- T:0.00WA NA 4670
    rs1219087161,2,,4
    CSevere combined immunodeficiency autosomal recessive T-cell-negative/B-cell-negative/NK-cell-negative due to adenosine deaminase deficiency (ADASCID)4 pathogenic143222423(-) TCACCA/GTACTG 2 H R mis10--------
    rs1219087401,2,,4
    CSevere combined immunodeficiency autosomal recessive T-cell-negative/B-cell-negative/NK-cell-negative due to adenosine deaminase deficiency (ADASCID)4 pathogenic143222424(-) TTCACC/TGTACT 2 R C mis10--------
    rs1219087221,2,,4
    CSevere combined immunodeficiency autosomal recessive T-cell-negative/B-cell-negative/NK-cell-negative due to adenosine deaminase deficiency (ADASCID)4 pathogenic143224950(-) CATGCA/GCCACC 2 H R mis10--------
    rs1219087351,2,,4
    CSevere combined immunodeficiency autosomal recessive T-cell-negative/B-cell-negative/NK-cell-negative due to adenosine deaminase deficiency (ADASCID)4 pathogenic143224951(-) GCATGC/TGCCAC 2 R C mis10--------

    HapMap Linkage Disequilibrium report for ADA (43248163 - 43280874 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ADA:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2668236CNV Deletion23128226
    esv24506CNV Loss19812545
    nsv498972CNV Loss21111241
    nsv3390CNV Loss18451855

    Human Gene Mutation Database (HGMD): ADA
    Locus Specific Mutation Databases (LSDB): ADA

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ADA
    DNA2.0 Custom Variant and Variant Library Synthesis for ADA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 608958   
    OMIM disorders: 102700  
    UniProtKB/Swiss-Prot: ADA_HUMAN, P00813
  • Severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-negative/NK-cell-negative due
    to adenosine deaminase deficiency (ADASCID) [MIM:102700]: An autosomal recessive disorder accounting for about
    50% of non-X-linked SCIDs. SCID refers to a genetically and clinically heterogeneous group of rare congenital
    disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent
    antibody levels. Patients with SCID present in infancy with recurrent, persistent infections by opportunistic
    organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to
    a defect in T-cell development. ADA deficiency has been diagnosed in chronically ill teenagers and adults (late
    or adult onset). Population and newborn screening programs have also identified several healthy individuals with
    normal immunity who have partial ADA deficiency. Note=The disease is caused by mutations affecting the gene
    represented in this entry

  • Selected diseases for ADA (see all 184):    
    About MalaCards
    peritonitis    miliary tuberculosis    adenosine deaminase deficiency    tuberculous peritonitis
    pleural tuberculosis    cauda equina syndrome    listeria meningitis    aseptic meningitis
    pleurisy    partial adenosine deaminase deficiency    pericardial effusion    congenital hemolytic anemia
    intestinal tuberculosis    extrapulmonary tuberculosis    tuberculous meningitis    meningitis
    pericarditis    abdominal tuberculosis    reticular dysgenesis    inosine triphosphate pyrophosphohydrolase deficiency

    9 diseases from the University of Copenhagen DISEASES database for ADA:
    Severe combined immunodeficiency     Tuberculosis     Purine nucleoside phosphorylase deficiency     Pleurisy
    Meningitis     Leukemia     Lymphopenia     Lymphoma
    Pericardial effusion

    ADA for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for ADA gene (see all 96)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adenosine deaminase deficiency 97.7 186 8879650 (3), 14612670 (3), 18020547 (3), 10202239 (2) (see all 99)
    pleurisy tuberculous 92 115 18222681 (6), 19543657 (4), 12921155 (4), 19901882 (4) (see all 54)
    severe combined immunodeficiency 88.8 196 10202239 (2), 8258146 (2), 9364370 (2), 1401934 (2) (see all 99)
    tuberculous ascites 83.7 22 12947727 (6), 8729756 (3), 16800787 (2), 2389724 (2) (see all 9)
    pericarditis tuberculous 82.2 37 11173777 (4), 8312671 (3), 12226030 (2), 17625694 (2) (see all 18)
    peritonitis tuberculous 81.4 50 7698702 (5), 2219461 (4), 8938171 (4), 11466036 (3) (see all 22)
    pleurisy 81.3 109 1392176 (5), 19407434 (3), 2149157 (3), 16447785 (3) (see all 43)
    effusion 80.5 404 11502629 (10), 12608433 (7), 8656037 (7), 16737998 (6) (see all 99)
    meningitis tuberculous 74.7 53 7837719 (5), 17333738 (3), 2028233 (3), 8935128 (3) (see all 25)
    tuberculosis 72.1 196 12685967 (4), 10893921 (4), 10596453 (4), 8584540 (4) (see all 99)

    Genatlas disease: ADA
    SCID,autosomal recessive,immunodeficiency,severe,combined (complete ADA deficiency),associating immunodeficiency
    (B-T cell CD4-lympho and thrombopenia),skeletal dysplasia,recurrent respiratory infections and
    asthma,hepatoplenomegaly,or slow progressive or late onset (partial ADA deficiency)

    GeneTests: ADA
    GeneReviews: ADA
    Genetic Association Database (GAD): ADA
    Human Genome Epidemiology (HuGE) Navigator: ADA (50 documents)

    Export disorders for ADA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for ADA gene, integrated from 10 sources (see all 1425):
    (articles sorted by number of sources associating them with ADA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human adenosine deaminase. cDNA and complete primary amino acid sequence. (PubMed id 6090454)1, 2, 3 Daddona P.E....Orkin S.H. (J. Biol. Chem. 1984)
    2. Two newly identified mutations (Thr233Ile and Leu152Met) in partially adenosine deaminase-deficient (ADA-) individuals that result in differing biochemical and metabolic phenotypes. (PubMed id 9225964)1, 2, 9 Hirschhorn R.... Jenkins T. (Hum. Genet. 1997)
    3. Three new adenosine deaminase mutations that define a splicing enhancer and cause severe and partial phenotypes: implications for evolution of a CpG hotspot and expression of a transduced ADA cDNA. (PubMed id 8589684)1, 2, 9 Santisteban I....Hershfield M.S. (Hum. Mol. Genet. 1995)
    4. Regulation of epithelial and lymphocyte cell adhesion by adenosine deaminase-CD26 interaction. (PubMed id 11772392)1, 2, 9 Gines S.... Franco R. (Biochem. J. 2002)
    5. Direct association of adenosine deaminase with a T cell activation antigen, CD26. (PubMed id 8101391)1, 2, 9 Kameoka J.... Morimoto C. (Science 1993)
    6. The role of adenosine-related genes variants in susceptibility to essential hypertension. (PubMed id 15257174)1, 4, 9 Wright K....Griffiths L.R. (J. Hypertens. 2004)
    7. Genetic predisposition of responsiveness to therapy for chronic hepatitis C. (PubMed id 16886895)1, 4, 9 Hwang Y....Chen D.S. (Pharmacogenomics 2006)
    8. A functional genetic variation of adenosine deaminase affects the duration and intensity of deep sleep in humans. (PubMed id 16221767)1, 2, 9 Retey J.V.... Landolt H.-P. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    9. Adenosine deaminase alleles and autistic disorder: case-control and family-based association studies. (PubMed id 11121182)1, 4, 9 Persico A.M....Keller F. (Am. J. Med. Genet. 2000)
    10. Four new adenosine deaminase mutations, altering a zinc-binding histidine, two conserved alanines, and a 5' splice site. (PubMed id 7599635)1, 2, 9 Santisteban I.... Hershfield M.S. (Hum. Mutat. 1995)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 100 HGNC: 186 AceView: ADA Ensembl:ENSG00000196839 euGenes: HUgn100
    ECgene: ADA Kegg: 100 H-InvDB: ADA

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for ADA Pharmacogenomics, SNPs, Pathways
    ADAbasehttp://bioinf.uta.fi/ADAbase/
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=ADA[genesymbol]
    Wikipedia http://en.wikipedia.org/wiki/Adenosine_deaminase

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for ADA gene:
    Search GeneIP for patents involving ADA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of ADA
     Browse Purified and Recombinant Proteins at EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Antibodies for ADA (Adenosine Deaminase/ADA)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for ADA (Adenosine Deaminase/ADA)   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for ADA   OriGene RNAi products in human, mouse, rat for ADA  
     OriGene qPCR primer pairs and template standards for ADA   OriGene Protein Over-expression Lysate for ADA  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for ADA  
     OriGene qSTAR qPCR primer pairs in human, mouse for ADA   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for ADA   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ADA   OriGene Custom Protein Services for ADA  

     
     
     Block miRNA regulation of human, mouse, rat ADA using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ADA
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ADA Predesigned siRNA for gene silencing in human, mouse, rat ADA
     QuantiFast Probe-based Assays in human, mouse, rat ADA QuantiTect SYBR Green Assays in human, mouse, rat ADA
     PCR Arrays including human, mouse, rat ADA Search Chromatin IP Primers for ADA
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ADA  GeneGlobe Interaction Network for ADA
     Regulatory tfbs in ADA promoter
     GenScript Custom Purified and Recombinant Proteins Services for ADA GenScript cDNA clones with any tag delivered in your preferred vector for ADA
     GenScript Custom Assay Services for ADA GenScript Custom overexpressing Cell Line Services for ADA
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Tocris compounds for ADA
     Proteins for ADA
     Cell Lysates for ADA
     cDNA Clones for ADA
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Drugs for ADA
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     ADA antibodies
     ADA proteins
     ADA lysates
     Antibodies for ADA
     See all of Abcam's Antibodies, Kits and Proteins for ADA
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for ADA
     Proteins for ADA
     Antibodies for ADA
     ELISAs for ADA
     CLIAs for ADA



     Browse ESI BIO Cell Lines and PureStem Progenitors for ADA
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADA
     SwitchGear 3'UTR luciferase reporter plasmids for ADA
     SwitchGear Promoter luciferase reporter plasmids for ADA
     ThermoFisher Antibody for ADA
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADA
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ADA
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ADA
     LSBio Antibodies in human, mouse, rat for ADA
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ADA gene at Home site.
    Version: 3.12.142 28 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4