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ADA Gene

protein-coding GIFtS: 72

GC20M042681

adenosine deaminase
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 3.5.4.4 ^³

Descriptions
Adenosine aminohydrolase ^², ³
adenosine deaminase ^²

External Ids
HGNC: 186¹
Entrez Gene: 100²
UniProtKB: P00813³
Ensembl: ENSG00000196839⁷

Search outside databases for aliases for ADA gene

Previous GC identifers: GC20M042976 GC20M043886 GC20M043933

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for ADA:

This gene encodes an enzyme that catalyzes the hydrolysis of adenosine to inosine. Various

mutations have been described for this gene and have been linked to human diseases. Deficiency in

this enzyme causes a form of severe combined immunodeficiency disease (SCID), in which there is

dysfunction of both B and T lymphocytes with impaired cellular immunity and decreased production

of immunoglobulins, whereas elevated levels of this enzyme have been associated with congenital

hemolytic anemia. [provided by RefSeq]

Gene Wiki entry for ADA (Adenosine_deaminase)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ADA gene

Entrez Gene cytogenetic band: 20q12-q13.11 Ensembl cytogenetic band: 20q13.12 HGNC cytogenetic band: 20q13.12

ADA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20M042681: (about GC identifiers)

Start:	42,681,577 bp from pter
End:	42,713,795 bp from pter
Size:	32,219 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000020.9 NT_011362.9

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: ADA_HUMAN, P00813 (See protein sequence)

Recommended Name: Adenosine deaminase

Size: 363 amino acids; 40764 Da

PDB structures from and Proteopedia :

1M7M (3D)

Secondary accessions: Q53F92 Q6LA59

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_000013.2

ENSEMBL proteins:

ENSP00000379993 ENSP00000361965

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (ADA)
	Human Recombinant Proteins from Abnova (ADA)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--
GO:0005764	lysosome	IDA	8452534
GO:0005829	cytosol	EXP	3182793
GO:0009897	external side of plasma membrane	IDA	7759315 16670267
GO:0016020	membrane	IDA	11999881

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Antibodies for ADA:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of ADA
	Sigma-Aldrich Antibodies for ADA
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (ADA), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ADA)
	Novus Biologicals Antibodies for ADA

Assays for ADA:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P00813

ProtoNet protein and cluster: P00813

1 Blocks protein family: IPB006650 Adenosine/AMP deaminase active site

UniProtKB/Swiss-Prot: ADA_HUMAN, P00813

Similarity: Belongs to the adenosine and AMP deaminases family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ADA)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ADA)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000022

Applied Biosystems Silencer® siRNAs for ADA

Sigma-Aldrich siRNA and siRNA Panels for ADA

Sigma-Aldrich shRNA Panels and shRNA for ADA

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ADA
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000022
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000022
untagged cDNA clones in CMV expression vector (see all 2): AL832305

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000022

UniProtKB/Swiss-Prot: ADA_HUMAN, P00813

Catalytic activity: Adenosine + H(2)O = inosine + NH(3)

Enzyme Number (IUBMB): EC 3.5.4.4

Genatlas biochemistry entry for ADA:

adenosine deaminase,adenine nucleotide catalytic pathway,including a locus control region LCR-ADA

(see symbol) in intron 1

13 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Ada):

cellular	growth/size	hematopoietic system	homeostasis/metabolism	immune system
lethality-postnatal	lethality-prenatal/perinatal	liver/biliary system	normal	renal/urinary system
reproductive system	respiratory system	skeleton

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004000	adenosine deaminase activity	IDA	3182793 8452534 9361033 11999881 16670267
GO:0005515	protein binding	IPI	7594462 14684150
GO:0008270	zinc ion binding	IMP	7599635
GO:0016787	hydrolase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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2 Sigma-Aldrich "Your Favorite Gene" Pathways for ADA (Your Favorite Gene powered by Ingenuity)

Purine Metabolism
Primary Immunodeficiency Signaling

GeneDecks ADA for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for ADA

5/77 Interacting proteins for ADA (ENSP00000361965³) via UniProtKB, MINT, and/or STRING (see all 77 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DPP4	ENSP00000353731³	STRING (score=.995)
ADORA1	ENSP00000356205³	STRING (score=.99)
NP	ENSP00000354532³	STRING (score=.99)
TYMP	ENSP00000252029³	STRING (score=.987)
ADK	ENSP00000286621³	STRING (score=.982)

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5/26 Gene Ontology (GO) biological process terms (links to tree view) (see all 26 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001666	response to hypoxia	IDA	16670267
GO:0001701	in utero embryonic development	IEA	--
GO:0001829	trophectodermal cell differentiation	IEA	--
GO:0001889	liver development	IEA	--
GO:0001890	placenta development	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Sigma-Aldrich Small Molecules for ADA:

Inhibitor

Compounds for ADA available from Tocris Bioscience

Compound	Action	CAS number
EHNA hydrochloride	Adenosine deaminase inhibitor	[51350-19-7]
Pentostatin	Adenosine deaminase inhibitor	[53910-25-1]

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10/48 Novoseek chemical compound relationships for ADA gene (see all 48 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
inosine	88.69	100	15299191 (2), 11217148 (2), 1791825 (1), 9463389 (1) (see all 70)
deoxyadenosine	87.94	114	8726940 (6), 2303314 (3), 1373528 (2), 15804573 (2) (see all 59)
erythro-9-(2 hydroxy 3-nonyl)adenine	87.89	74	2002459 (3), 8519602 (2), 2382828 (2), 9399998 (2) (see all 29)
purine	82.74	139	1793856 (2), 1679757 (2), 19179314 (2), 2125239 (1) (see all 83)
1-deazaadenosine	81.47	5	8439534 (2), 18543763 (1), 1731884 (1)
nucleoside	70.07	29	8113801 (3), 7599155 (2), 8501937 (1), 11426528 (1) (see all 22)
deoxyinosine	69.80	10	15508788 (1), 14555239 (1), 15907156 (1), 10596453 (1) (see all 6)
2-amino-6-chloropurine	68.75	2	16359173 (1)
2 chloroadenosine	68.63	15	18242582 (1), 8995360 (1), 7687130 (1), 8875454 (1) (see all 9)
5'-amino-5'-deoxyadenosine	68.59	2	8605954 (1), 8832217 (1)

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1 PharmGKB drug compound relationship for ADA gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
methotrexate	FA	8254024

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ADA)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ADA)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000022

Sigma-Aldrich siRNA and siRNA Panels for ADA

Sigma-Aldrich shRNA Panels and shRNA for ADA

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000022

REFSEQ mRNAs for ADA gene:

NM_000022.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000022

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000022
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000022
                                 untagged cDNA clones in CMV expression vector (see all 2): AL832305

Additional cDNA sequence:

AK223397.1 BC007678.2 BC040226.1 CR590997.1 CR597186.1 CR597421.1 CR606425.1 CR607668.1

CR609012.1 CR609053.1 CR610127.1 CR611818.1 CR612145.1 CR615818.1 CR618876.1 CR619472.1

CR621286.1 CR622485.1 CR622953.1 CR623349.1 X02994.1

12 DOTS entries:

DT.100821717 DT.454795 DT.100821712 DT.91762938 DT.100821720 DT.100821718 DT.100728740 DT.100821723

DT.101982853 DT.91946218 DT.120810355 DT.120810467

24/176 AceView cDNA sequences (see all 176 ):

BU197309 CR618876 AW450871 BC040226 BU727033 CR597186 AK123988 BF982134

AA354600 T28970 AA309696 CR622485 CN484969 CR619472 CR612145 CR615818

NM_000022 BQ002923 BQ772534 BM463492 AL832305 CR610127 AL557287 CR597421

highest scoring ESTs for ADA:

X02994 AA312512 AL526282 BC007678 BC040226 BE407945 BE727733 BE728751 BE732464 BE733449

Unigene Cluster for ADA:

Adenosine deaminase

Hs.654536 [show with all ESTs]

Unigene Representative Sequence: BM809993

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for ADA

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13a	·	13b
SP1:
SP2:
SP3:
SP4:

About this scheme

ECgene alternative splicing isoforms for ADA

2 Ensembl transcripts including schematic representations:

ENST00000396772 ENST00000372874

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ADA expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ADA

¹ / ² / ³

6 probe-sets matching ADA gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
907_at²^{, 3}	U95-A	1	1.00	1.00	0.99	0.91	M13792	0.20	1.00	0.72	1
41654_at²^{, 3}	U95-A	1	1.00	1.00	0.99	1.09	X02994	1.00	1.00	1.00	1
216705_s_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
204639_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000022	0.60	1.00	0.82	1
216705_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
204639_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks ADA for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GCTGGTGGCA

SOURCE GeneReport for Unigene cluster: Hs.654536
Expression variation in blood from EXPOLDB for ADA
UniProtKB/Swiss-Prot: ADA_HUMAN, P00813
Tissue specificity: Found in all tissues, occurs in large amounts in T-lymphocytes and, at the time
of weaning, in gastrointestinal tissues

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ADA gene from 5/13 species (see all 13 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ADA¹	--	adenosine deaminase	87.07(n) 86.15(a)	477236 XM_534428.2 XP_534428.2
chimpanzee (Pan troglodytes)	ADA¹	--	adenosine deaminase	98.9(n) 98.35(a)	741760 XM_001144517.1 XP_001144517.1
cow (Bos taurus)	ADA¹	--	adenosine deaminase	87.7(n) 88.71(a)	280712 NM_173887.2 NP_776312.1
rat (Rattus norvegicus)	Ada¹	--	adenosine deaminase	83.38(n) 85.75(a)	24165 NM_130399.2 NP_569083.1
mouse (Mus musculus)	Ada^{1, 5}	2 (94.00 cM)⁵	adenosine deaminase^{1, 5}	81.58(n)¹ 83.48(a)¹	11486¹ NM_007398.3¹ NP_031424.1¹ AF483480⁵ AF483481⁵ (see all 28)

About this table Species with no ortholog for ADA

ENSEMBL Gene Tree for ADA

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

UniProtKB/Swiss-Prot: ADA_HUMAN, P00813

Polymorphism: There is a common allele, ADA*2, also known as the ADA 2 allozyme. It is associated

with the reduced metabolism of adenosine to inosine. It specifically enhances deep sleep and

slow-wave activity (SWA) during sleep

10/273 NCBI SNPs in ADA are shown (see all 273 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 133)

AB	SNP ID	Valid	Chr 20 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs11906526^1,2	C,F,H	42681716(+)	`AGTGAC/GGCGGC`	1	--	ut3¹ ese³		4		EU EA WA	420
--	rs11086932^1,2	A,C	42714792(+)	`AGGttA/Ttttat`	1	--	ng3¹ tfbs³		0	--	--	--	--
--	rs6103804^1,2	A,C	42715153(+)	`aagcaA/Gttctc`	1	--	ng3¹		0	--	--	--	--
--	rs6065738^1,2	A,C	42715253(+)	`atgttG/Tgccag`	1	--	ng3¹		0	--	--	--	--
--	rs435679^1,2	C	42714936(+)	`accgcC/Tccccc`	1	--	ng3¹		0	--	--	--	--
	rs1042360^1,2	H	42686350(-)	`AAGAAG/CTACCA`	1	N/K	mis¹		5		MN EU EA WA	588
--	rs6031700^1,2	C	42715224(+)	`tggatC/Ttgtag`	1	--	ng3¹		0	--	--	--	--
--	rs244076^1,2	A,C,F,H	42686329(-)	`GTGGTA/GGCCAT`	1	V/V	syn¹ ese³		8		MN EU EA WA NA	740
--	rs7344760^1,2	H	42687721(+)	`ACCTCG/ATCTGG`	1	D/D	syn¹ ese³		4		EU EA WA	414
	rs394105^1,2	C	42698341(+)	`AGTTCC/TACCTG`	1	V/V	syn¹		0	--	--	--	--

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HapMap Linkage Disequilibrium images for ADA (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 608958 disorders: 102700 102700

UniProtKB/Swiss-Prot: ADA_HUMAN, P00813

Defects in ADA are the cause of severe combined immunodeficiency autosomal recessive

T-cell-negative/B-cell-negative/NK-cell-negative due to adenosine deaminase deficiency (ADASCID)

[MIM:102700]. SCID refers to a genetically and clinically heterogeneous group of rare congenital

disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and

low or absent antibody levels. Patients with SCID present in infancy with recurrent, persistent

infections by opportunistic organisms. The common characteristic of all types of SCID is absence

of T-cell-mediated cellular immunity due to a defect in T-cell development. ADA-SCID is an

autosomal recessive form accounting for about 50% of non-X-linked SCIDs. ADA deficiency has been

diagnosed in chronically ill teenagers and adults (late or adult onset). Population and newborn

screening programs have also identified several healthy individuals with normal immunity who have

partial ADA deficiency

In hereditary hemolytic anemia, the level of this enzyme in erythrocytes increases 50-70

times

10/96 Novoseek disease relationships for ADA gene (see all 96 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
adenosine deaminase deficiency	97.70	178	8879650 (3), 14612670 (3), 18020547 (3), 10202239 (2) (see all 99)
pleurisy tuberculous	91.81	104	18222681 (6), 12921155 (4), 8726940 (4), 9513525 (3) (see all 51)
severe combined immunodeficiency	88.66	189	10202239 (2), 8258146 (2), 9364370 (2), 8120281 (2) (see all 99)
tuberculous ascites	84.38	22	12947727 (6), 8729756 (3), 16800787 (2), 2389724 (2) (see all 9)
pericarditis tuberculous	82.30	35	11173777 (4), 8312671 (3), 12226030 (2), 17625694 (2) (see all 18)
pleurisy	81.06	92	1392176 (5), 2149157 (3), 16447785 (3), 12915746 (3) (see all 39)
effusion	80.42	377	11502629 (10), 12608433 (7), 8656037 (7), 16737998 (6) (see all 99)
peritonitis tuberculous	79.84	50	7698702 (5), 2219461 (4), 8938171 (4), 11466036 (3) (see all 22)
meningitis tuberculous	71.53	46	7837719 (5), 17333738 (3), 2028233 (3), 8935128 (3) (see all 21)
tuberculosis	71.40	182	12685967 (4), 10893921 (4), 10596453 (4), 8584540 (4) (see all 98)

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2 PharmGKB disease relationships for ADA gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Asthma	FA	11792620
Leukemia, Lymphocytic, Acute, L1	FA	6981287

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Genatlas disease: ADA

SCID,autosomal recessive,immunodeficiency,severe,combined (complete ADA deficiency),associating

immunodeficiency (B-T cell CD4-lympho and thrombopenia),skeletal dysplasia,recurrent respiratory

infections and asthma,hepatoplenomegaly,or slow progressive or late onset (partial ADA deficiency)

GeneTests: ADA

Adenosine Deaminase Deficiency

Human Gene Mutation Database: ADA
Genetic Association Database: ADA
Human Genome Epidemiology Navigator: ADA (27 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/1111 PubMed articles for ADA gene (see all 1111 ):

Human adenosine deaminase. cDNA and complete primary amino acid sequence. (PubMed id 6090454)^{2, 3, 4} Daddona P.E....Orkin S.H. (1984)
Two newly identified mutations (Thr233Ile and Leu152Met) in partially adenosine deaminase-deficient (ADA-) individuals that result in differing biochemical and metabolic phenotypes. (PubMed id 9225964)^{1, 3, 4} Hirschhorn R.... Jenkins T. (1997)
Three new adenosine deaminase mutations that define a splicing enhancer and cause severe and partial phenotypes: implications for evolution of a CpG hotspot and expression of a transduced ADA cDNA. (PubMed id 8589684)^{1, 3, 4} Santisteban I....Hershfield M.S. (1995)
Genetic polymorphism and TH1/TH2 orientation. (PubMed id 16224193)^{1, 3, 6} Bottini N....Bottini E. (2005)
The role of adenosine-related genes variants in susceptibility to essential hypertension. (PubMed id 15257174)^{1, 3, 6} Wright K....Griffiths L.R. (2004)
A functional genetic variation of adenosine deaminase affects the duration and intensity of deep sleep in humans. (PubMed id 16221767)^{1, 3, 4} Retey J.V.... Landolt H.-P. (2005)
Adenosine deaminase alleles and autistic disorder: case-control and family-based association studies. (PubMed id 11121182)^{1, 3, 6} Persico A.M....Keller F. (2000)
Four new adenosine deaminase mutations, altering a zinc-binding histidine, two conserved alanines, and a 5' splice site. (PubMed id 7599635)^{1, 3, 4} Santisteban I.... Hershfield M.S. (1995)
Homozygosity for a missense mutation (G20R) associated with neonatal onset adenosine deaminase-deficient severe combined immunodeficiency (ADA-SCID). (PubMed id 8299233)^{1, 3, 4} Yang D.R.... Hirschhorn R. (1994)
Novel splicing, missense, and deletion mutations in seven adenosine deaminase-deficient patients with late/delayed onset of combined immunodeficiency disease. Contribution of genotype to phenotype. (PubMed id 8227344)^{1, 3, 4} Santisteban I.... Hershfield M.S. (1993)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 100	HGNC: 186	AceView: ADA	Ensembl:ENSG00000196839	euGenes: HUgn100
ECgene: ADA	H-InvDB: ADA

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ADAbase	http://bioinf.uta.fi/ADAbase/
GeneReviews	http://www.genetests.org/query?gene=ADA
Wikipedia	http://en.wikipedia.org/wiki/Adenosine_deaminase

Licensable Technologies for ADA
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ADA:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ADA-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ADA		Antibodies for ADA
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ADA		Small molecules for ADA
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (ADA)
	Antibodies (ADA)
	Chimera RNAi (ADA)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (ADA)
	Antibodies (ADA)

Search OriGene for ADA

Tocris compounds for ADA

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for ADA

GeneCards Homepage - Last full update: 1 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
ADA Gene at Home site.
Version 2.41.1
server5.xennexinc.com

ADA Gene

protein-coding GIFtS: 72

Aliases &
Descriptions
for ADA

Summaries
for ADA

Genomic Location
for ADA

Proteins
for ADA

Protein Domains/
Families
for ADA

Gene Function
for ADA

Pathways & Interactions
for ADA

Drugs & Compounds
for ADA

Transcripts
for ADA

Expression
for ADA

Orthologs
for ADA

Paralogs
for ADA

SNPs/Variants
for ADA

Disorders & Mutations
for ADA

Medical News
for ADA

Publications
for ADA

Search for ADA

Genome Databases showing ADA

Other Databases showing ADA

Specialized Databases showing ADA

Licensable Technologies
for ADA

Services
for ADA

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ADA Gene

protein-coding GIFtS: 72

Aliases & Descriptionsfor ADA

Summariesfor ADA

Genomic Locationfor ADA

Proteinsfor ADA

Protein Domains/Familiesfor ADA

Gene Functionfor ADA

Pathways & Interactionsfor ADA

Drugs & Compoundsfor ADA

Transcriptsfor ADA

Expression for ADA

Orthologsfor ADA

Paralogsfor ADA

SNPs/Variantsfor ADA

Disorders & Mutationsfor ADA

Medical Newsfor ADA

Publicationsfor ADA

Search for ADA

Genome Databases showing ADA

Other Databases showing ADA

Specialized Databases showing ADA

Licensable Technologiesfor ADA

Servicesfor ADA

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ADA

Summaries
for ADA

Genomic Location
for ADA

Proteins
for ADA

Protein Domains/
Families
for ADA

Gene Function
for ADA

Pathways & Interactions
for ADA

Drugs & Compounds
for ADA

Transcripts
for ADA

Expression
for ADA

Orthologs
for ADA

Paralogs
for ADA

SNPs/Variants
for ADA

Disorders & Mutations
for ADA

Medical News
for ADA

Publications
for ADA

Licensable Technologies
for ADA

Services
for ADA