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Aliases for ACYP2 Gene

Aliases for ACYP2 Gene

  • Acylphosphatase 2 2 3
  • Acylphosphatase 2, Muscle Type 2 3 5
  • Acylphosphatase, Muscle Type Isozyme 3 4
  • Acylphosphate Phosphohydrolase 2 3 4
  • EC 4 63
  • ACYP 3 4
  • Testicular Tissue Protein Li 11 3
  • ACYM 3

External Ids for ACYP2 Gene

Previous GeneCards Identifiers for ACYP2 Gene

  • GC02P054380
  • GC02P054528
  • GC02P054155
  • GC02P054316
  • GC02P054254
  • GC02P054342
  • GC02P054199

Summaries for ACYP2 Gene

Entrez Gene Summary for ACYP2 Gene

  • Acylphosphatase can hydrolyze the phosphoenzyme intermediate of different membrane pumps, particularly the Ca2+/Mg2+-ATPase from sarcoplasmic reticulum of skeletal muscle. Two isoenzymes have been isolated, called muscle acylphosphatase and erythrocyte acylphosphatase on the basis of their tissue localization. This gene encodes the muscle-type isoform (MT). An increase of the MT isoform is associated with muscle differentiation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]

GeneCards Summary for ACYP2 Gene

ACYP2 (Acylphosphatase 2) is a Protein Coding gene. Among its related pathways are Pyrimidine metabolism (KEGG) and Pyruvate metabolism. GO annotations related to this gene include acylphosphatase activity. An important paralog of this gene is ACYP1.

UniProtKB/Swiss-Prot for ACYP2 Gene

  • Its physiological role is not yet clear.

Gene Wiki entry for ACYP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACYP2 Gene

Genomics for ACYP2 Gene

Regulatory Elements for ACYP2 Gene

Enhancers for ACYP2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ACYP2 on UCSC Golden Path with GeneCards custom track

Promoters for ACYP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ACYP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for ACYP2 Gene

53,970,838 bp from pter
54,305,300 bp from pter
334,463 bases
Plus strand

Genomic View for ACYP2 Gene

Genes around ACYP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACYP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACYP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACYP2 Gene

Proteins for ACYP2 Gene

  • Protein details for ACYP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:

    Protein attributes for ACYP2 Gene

    99 amino acids
    Molecular mass:
    11140 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ACYP2 Gene

Proteomics data for ACYP2 Gene at MOPED

Selected DME Specific Peptides for ACYP2 Gene

Post-translational modifications for ACYP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for ACYP2 Gene

Protein Domains for ACYP2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 acylphosphatase-like domain.
  • Belongs to the acylphosphatase family.
  • Contains 1 acylphosphatase-like domain.
  • Belongs to the acylphosphatase family.
genes like me logo Genes that share domains with ACYP2: view

No data available for Gene Families for ACYP2 Gene

Function for ACYP2 Gene

Molecular function for ACYP2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
An acylphosphate + H(2)O = a carboxylate + phosphate.
UniProtKB/Swiss-Prot Function:
Its physiological role is not yet clear.

Enzyme Numbers (IUBMB) for ACYP2 Gene

genes like me logo Genes that share phenotypes with ACYP2: view

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ACYP2 Gene

Localization for ACYP2 Gene

Subcellular locations from

Jensen Localization Image for ACYP2 Gene COMPARTMENTS Subcellular localization image for ACYP2 gene
Compartment Confidence
nucleus 3
cytosol 2
mitochondrion 2
endoplasmic reticulum 1
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ACYP2 Gene

Pathways & Interactions for ACYP2 Gene

genes like me logo Genes that share pathways with ACYP2: view

Pathways by source for ACYP2 Gene

1 KEGG pathway for ACYP2 Gene
1 GeneGo (Thomson Reuters) pathway for ACYP2 Gene

Gene Ontology (GO) - Biological Process for ACYP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006796 phosphate-containing compound metabolic process TAS 8268218
genes like me logo Genes that share ontologies with ACYP2: view

No data available for SIGNOR curated interactions for ACYP2 Gene

Drugs & Compounds for ACYP2 Gene

(16) Drugs for ACYP2 Gene - From: DrugBank, PharmGKB, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cisplatin Approved Pharma Inhibits DNA synthesis,chemotherapy drug, Platinum 2569
acetic acid Approved Nutra Full agonist, Agonist 97
Formic acid Experimental Pharma Target 0
3-Phosphoglyceric acid Experimental Pharma 0
Acetylphosphate Experimental Pharma 0

(9) Additional Compounds for ACYP2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Arachidic acid
  • Arachate
  • Arachic acid
  • Arachidate
  • Arachidic acid
  • Eicosanoate
Benzoyl phosphate
Glyceric acid 1,3-biphosphate
  • 1,3-Biphosphoglycerate
  • 1,3-Biphosphoglyceric acid
  • 1,3-Bis-phosphoglycerate
  • 1,3-Bisphosphoglycerate
  • 1,3-Diphosphateglycerate
Heptadecanoic acid
  • Heptadecanoate
  • Heptadecanoic acid
  • Margarate
  • Margaric acid
  • Margarinate
Heptadecanoyl CoA
  • Heptadecanoate
  • Heptadecanoic acid
  • Heptadecanoic acid coa
  • Heptadecanoyl coenzyme A
  • Heptadecanoyl-coA
genes like me logo Genes that share compounds with ACYP2: view

Transcripts for ACYP2 Gene

Unigene Clusters for ACYP2 Gene

Acylphosphatase 2, muscle type:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ACYP2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c
SP1: - - - - - -
SP2: - - - - -
SP3: - -
SP4: - -
SP5: - - - - - - -

Relevant External Links for ACYP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ACYP2 Gene

mRNA expression in normal human tissues for ACYP2 Gene

mRNA differential expression in normal tissues according to GTEx for ACYP2 Gene

This gene is overexpressed in Muscle - Skeletal (x4.3).

Protein differential expression in normal tissues from HIPED for ACYP2 Gene

This gene is overexpressed in Spinal cord (17.2), Nasal epithelium (10.0), and Brain (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ACYP2 Gene

SOURCE GeneReport for Unigene cluster for ACYP2 Gene Hs.516173

genes like me logo Genes that share expression patterns with ACYP2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ACYP2 Gene

Orthologs for ACYP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ACYP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ACYP2 35
  • 92.26 (n)
  • 93.94 (a)
ACYP2 36
  • 94 (a)
(Canis familiaris)
Mammalia ACYP2 35
  • 91.25 (n)
  • 93.94 (a)
ACYP2 36
  • 73 (a)
(Mus musculus)
Mammalia Acyp2 35
  • 82.65 (n)
  • 83.67 (a)
Acyp2 16
Acyp2 36
  • 77 (a)
(Pan troglodytes)
Mammalia ACYP2 35
  • 98.99 (n)
  • 98.99 (a)
ACYP2 36
  • 64 (a)
(Rattus norvegicus)
Mammalia Acyp2 35
  • 85.37 (n)
  • 87.76 (a)
(Ornithorhynchus anatinus)
Mammalia ACYP2 36
  • 68 (a)
(Gallus gallus)
Aves ACYP2 35
  • 83.33 (n)
  • 89.36 (a)
ACYP2 36
  • 82 (a)
(Anolis carolinensis)
Reptilia ACYP2 36
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia acyp2 35
  • 75.27 (n)
  • 83.87 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4320 35
(Danio rerio)
Actinopterygii CABZ01090073.1 36
  • 46 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008311 35
  • 49.1 (n)
  • 43.01 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14022 35
  • 51.25 (n)
  • 44.09 (a)
CG14022 36
  • 41 (a)
Species with no ortholog for ACYP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ACYP2 Gene

Gene Tree for ACYP2 (if available)
Gene Tree for ACYP2 (if available)

Paralogs for ACYP2 Gene

Paralogs for ACYP2 Gene

genes like me logo Genes that share paralogs with ACYP2: view

Variants for ACYP2 Gene

Sequence variations from dbSNP and Humsavar for ACYP2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs698749 -- 54,195,215(-) CCATA(A/G)AATCT intron-variant
rs698750 -- 54,195,244(-) TTGGT(C/T)TGTGA intron-variant
rs698751 -- 54,210,840(+) AGCCT(A/G)ATTGA intron-variant
rs698752 -- 54,226,673(+) ACATG(G/T)AGTCT intron-variant
rs698753 -- 54,227,629(+) AAAAA(A/C)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ACYP2 Gene

Variant ID Type Subtype PubMed ID
esv2720078 CNV Deletion 23290073
esv23028 CNV Loss 19812545
dgv4143n71 CNV Loss 21882294
esv2664152 CNV Deletion 23128226
esv2720079 CNV Deletion 23290073
nsv525086 CNV Loss 19592680
nsv457897 CNV Gain 19166990
esv27584 CNV Loss 19812545
esv2665732 CNV Deletion 23128226
nsv507013 CNV Insertion 20534489
esv2318898 CNV Deletion 18987734

Variation tolerance for ACYP2 Gene

Residual Variation Intolerance Score: 74.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.85; 73.97% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ACYP2 Gene

Disorders for ACYP2 Gene

Relevant External Links for ACYP2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ACYP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ACYP2 Gene

Publications for ACYP2 Gene

  1. Common variants in ACYP2 influence susceptibility to cisplatin-induced hearing loss. (PMID: 25665007) Xu H. … Yang J.J. (Nat. Genet. 2015) 2 3 67
  2. Mutational analysis of acylphosphatase suggests the importance of topology and contact order in protein folding. (PMID: 10542090) Chiti F. … Dobson C.M. (Nat. Struct. Biol. 1999) 3 23
  3. Differential migration of acylphosphatase isoenzymes from cytoplasm to nucleus during apoptotic cell death. (PMID: 9070879) Chiarugi P. … Ramponi G. (Biochem. Biophys. Res. Commun. 1997) 3 23
  4. Chemical synthesis and expression of a gene coding for human muscle acylphosphatase. (PMID: 8268218) Modesti A. … Ramponi G. (Biochim. Biophys. Acta 1993) 2 3
  5. Genetic determinants of chronic oxaliplatin-induced peripheral neurotoxicity: a genome-wide study replication and meta-analysis. (PMID: 25858589) Terrazzino S. … Cavaletti G. (J. Peripher. Nerv. Syst. 2015) 3

Products for ACYP2 Gene

Sources for ACYP2 Gene