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Aliases for ACYP2 Gene

Aliases for ACYP2 Gene

  • Acylphosphatase 2, Muscle Type 2 3
  • ACYP 3 4 6
  • Acylphosphatase, Muscle Type Isozyme 3 4
  • Acylphosphate Phosphohydrolase 2 3 4
  • EC 4 64
  • Acylphosphatase-2 3
  • ACYM 3

External Ids for ACYP2 Gene

Summaries for ACYP2 Gene

Entrez Gene Summary for ACYP2 Gene

  • Acylphosphatase can hydrolyze the phosphoenzyme intermediate of different membrane pumps, particularly the Ca2+/Mg2+-ATPase from sarcoplasmic reticulum of skeletal muscle. Two isoenzymes have been isolated, called muscle acylphosphatase and erythrocyte acylphosphatase on the basis of their tissue localization. This gene encodes the muscle-type isoform (MT). An increase of the MT isoform is associated with muscle differentiation. [provided by RefSeq, Jul 2008]

GeneCards Summary for ACYP2 Gene

ACYP2 (Acylphosphatase 2, Muscle Type) is a Protein Coding gene. Among its related pathways are Pyruvate metabolism and Purine metabolism (KEGG). GO annotations related to this gene include acylphosphatase activity. An important paralog of this gene is ACYP1.

UniProtKB/Swiss-Prot for ACYP2 Gene

  • Its physiological role is not yet clear

Gene Wiki entry for ACYP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACYP2 Gene

Genomics for ACYP2 Gene

Genomic Location for ACYP2 Gene

53,970,838 bp from pter
54,305,300 bp from pter
334,463 bases
Plus strand

Genomic View for ACYP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ACYP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACYP2 Gene

Regulatory Elements for ACYP2 Gene

Proteins for ACYP2 Gene

  • Protein details for ACYP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:

    Protein attributes for ACYP2 Gene

    99 amino acids
    Molecular mass:
    11140 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ACYP2 Gene

Proteomics data for ACYP2 Gene at MOPED

Selected DME Specific Peptides for ACYP2 Gene

Post-translational modifications for ACYP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains for ACYP2 Gene

Protein Domains for ACYP2 Gene


  • Contains 1 acylphosphatase-like domain.:
    • P14621
  • Belongs to the acylphosphatase family.:
    • P14621
genes like me logo Genes that share domains with ACYP2: view

No data available for Gene Families for ACYP2 Gene

Function for ACYP2 Gene

Molecular function for ACYP2 Gene

UniProtKB/Swiss-Prot CatalyticActivity: An acylphosphate + H(2)O = a carboxylate + phosphate
UniProtKB/Swiss-Prot Function: Its physiological role is not yet clear

Enzyme Numbers (IUBMB) for ACYP2 Gene

Gene Ontology (GO) - Molecular Function for ACYP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003998 acylphosphatase activity IBA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with ACYP2: view

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ACYP2 Gene

Localization for ACYP2 Gene

Subcellular locations from

Jensen Localization Image for ACYP2 Gene COMPARTMENTS Subcellular localization image for ACYP2 gene
Compartment Confidence
cytosol 2
endoplasmic reticulum 2
mitochondrion 2
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ACYP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with ACYP2: view

Pathways for ACYP2 Gene

genes like me logo Genes that share pathways with ACYP2: view

Pathways by source for ACYP2 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for ACYP2 Gene
1 KEGG pathway for ACYP2 Gene

Gene Ontology (GO) - Biological Process for ACYP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006796 phosphate-containing compound metabolic process TAS 8268218
GO:0008152 metabolic process --
genes like me logo Genes that share ontologies with ACYP2: view

Compounds for ACYP2 Gene

(13) HMDB Compounds for ACYP2 Gene

Compound Synonyms Cas Number PubMed IDs
Acetic acid
  • Acetate
Arachidic acid
  • Arachate
Arachidonic acid
  • 5,8,11,14-Eicosatetraenoic acid
Benzoic acid
  • Benzenecarboxylate
Heptadecanoic acid
  • Heptadecanoate

(1) Drugbank Compounds for ACYP2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Formic Acid
  • Aminic acid
64-18-6 target

(5) Novoseek inferred chemical compound relationships for ACYP2 Gene

Compound -log(P) Hits PubMed IDs
trifluoroethanol 56.8 1
urea 43 2
lysine 21.7 1
alanine 11.5 1
calcium 0 3
genes like me logo Genes that share compounds with ACYP2: view

Transcripts for ACYP2 Gene

mRNA/cDNA for ACYP2 Gene

Unigene Clusters for ACYP2 Gene

Acylphosphatase 2, muscle type:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ACYP2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c
SP1: - - - - - -
SP2: - - - - -
SP3: - -
SP4: - -
SP5: - - - - - - -

Relevant External Links for ACYP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ACYP2 Gene

mRNA expression in normal human tissues for ACYP2 Gene

mRNA differential expression in normal tissues according to GTEx for ACYP2 Gene

This gene is overexpressed in Muscle - Skeletal (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ACYP2 Gene

SOURCE GeneReport for Unigene cluster for ACYP2 Gene Hs.516173

genes like me logo Genes that share expressions with ACYP2: view

Orthologs for ACYP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ACYP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ACYP2 36
  • 98.99 (n)
  • 98.99 (a)
ACYP2 37
  • 64 (a)
(Bos Taurus)
Mammalia ACYP2 36
  • 92.26 (n)
  • 93.94 (a)
ACYP2 37
  • 94 (a)
(Canis familiaris)
Mammalia ACYP2 36
  • 91.25 (n)
  • 93.94 (a)
ACYP2 37
  • 73 (a)
(Mus musculus)
Mammalia Acyp2 36
  • 82.65 (n)
  • 83.67 (a)
Acyp2 16
Acyp2 37
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia ACYP2 37
  • 68 (a)
(Rattus norvegicus)
Mammalia Acyp2 36
  • 85.37 (n)
  • 87.76 (a)
(Gallus gallus)
Aves ACYP2 36
  • 83.33 (n)
  • 89.36 (a)
ACYP2 37
  • 82 (a)
(Anolis carolinensis)
Reptilia ACYP2 37
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia acyp2 36
  • 75.27 (n)
  • 83.87 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4320 36
(Danio rerio)
Actinopterygii CABZ01090073.1 37
  • 46 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008311 36
  • 49.1 (n)
  • 43.01 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14022 36
  • 51.25 (n)
  • 44.09 (a)
CG14022 37
  • 41 (a)
Species with no ortholog for ACYP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ACYP2 Gene

Gene Tree for ACYP2 (if available)
Gene Tree for ACYP2 (if available)

Paralogs for ACYP2 Gene

Paralogs for ACYP2 Gene

genes like me logo Genes that share paralogs with ACYP2: view

Variants for ACYP2 Gene

Sequence variations from dbSNP and Humsavar for ACYP2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs11980 -- 54,305,026(-) AAATA(C/T)TTTGT utr-variant-3-prime
rs15136 -- 54,304,940(-) ACATT(A/T)TTAGT utr-variant-3-prime
rs698749 -- 54,195,215(-) CCATA(A/G)AATCT intron-variant
rs698750 -- 54,195,244(-) TTGGT(C/T)TGTGA intron-variant
rs698751 -- 54,210,840(+) AGCCT(A/G)ATTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ACYP2 Gene

Variant ID Type Subtype PubMed ID
esv2720078 CNV Deletion 23290073
esv23028 CNV Loss 19812545
dgv4143n71 CNV Loss 21882294
esv2664152 CNV Deletion 23128226
esv2720079 CNV Deletion 23290073
nsv525086 CNV Loss 19592680
nsv457897 CNV Gain 19166990
esv27584 CNV Loss 19812545
esv2665732 CNV Deletion 23128226
nsv507013 CNV Insertion 20534489
esv2318898 CNV Deletion 18987734

Relevant External Links for ACYP2 Gene

HapMap Linkage Disequilibrium report

Disorders for ACYP2 Gene

Relevant External Links for ACYP2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with ACYP2: view

No data available for UniProtKB/Swiss-Prot for ACYP2 Gene

Publications for ACYP2 Gene

  1. Differential migration of acylphosphatase isoenzymes from cytoplasm to nucleus during apoptotic cell death. (PMID: 9070879) Chiarugi P. … Ramponi G. (Biochem. Biophys. Res. Commun. 1997) 3 23
  2. Mutational analysis of acylphosphatase suggests the importance of topology and contact order in protein folding. (PMID: 10542090) Chiti F. … Dobson C.M. (Nat. Struct. Biol. 1999) 3 23
  3. Cloning and expression of the cDNA coding for the erythrocyte isoenzyme of human acylphosphatase. (PMID: 7796909) Fiaschi T. … Ramponi G. (FEBS Lett. 1995) 3 4
  4. Chemical synthesis and expression of a gene coding for human muscle acylphosphatase. (PMID: 8268218) Modesti A. … Ramponi G. (Biochim. Biophys. Acta 1993) 2 3
  5. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PMID: 19851296) Oguri M. … Yamada Y. (Am. J. Hypertens. 2010) 3 49

Products for ACYP2 Gene

Sources for ACYP2 Gene

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