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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ACYP1 Gene

protein-coding   GIFtS: 59
GCID: GC14M075519

Acylphosphatase 1, Erythrocyte (Common) Type

  Search for ACYP1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Acylphosphatase 1, Erythrocyte (Common) Type1 2     Acylphosphate Phosphohydrolase 12 3
ACYPE2 3 5     acylphosphatase-12
Acylphosphatase, Erythrocyte Isozyme2 3     EC 3.6.1.73
Acylphosphatase, Organ-Common Type Isozyme2 3     

External Ids:    HGNC: 1791   Entrez Gene: 972   Ensembl: ENSG000001196407   OMIM: 6008755   UniProtKB: P073113   

Export aliases for ACYP1 gene to outside databases

Previous GC identifers: GC14M073046 GC14M069337 GC14M073509 GC14M074589 GC14M055688


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ACYP1 Gene:
Acylphosphatase is a small cytosolic enzyme that catalyzes the hydrolysis of the carboxyl-phosphate bond of
acylphosphates. Two isoenzymes have been isolated, called muscle acylphosphatase and erythrocyte acylphosphatase,
on the basis of their tissue localization. This gene encodes the erythrocyte acylphosphatase isoenzyme.
Alternatively spliced transcript variants that encode different proteins were identified through data analysis.
(provided by RefSeq, Jul 2008)

GeneCards Summary for ACYP1 Gene: 
ACYP1 (acylphosphatase 1, erythrocyte (common) type) is a protein-coding gene. Among its related super-pathways are Benzo(a)pyrene metabolism and Purine metabolism. GO annotations related to this gene include acylphosphatase activity. An important paralog of this gene is ACYP2.

UniProtKB/Swiss-Prot: ACYP1_HUMAN, P07311
Function: Its physiological role is not yet clear

Gene Wiki entry for ACYP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NT_026437.12  NC_018925.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ACYP1 gene promoter:
         STAT1   Brachyury   IRF-1   STAT1alpha   Roaz   POU2F1   POU2F1a   STAT2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidACYP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ACYP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ACYP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.3   Ensembl cytogenetic band:  14q24.3   HGNC cytogenetic band: 14q24.3

ACYP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ACYP1 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M075519:  view genomic region     (about GC identifiers)

Start:
75,519,924 bp from pter      End:
75,536,186 bp from pter
Size:
16,263 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ACYP1_HUMAN, P07311 (See protein sequence)
Recommended Name: Acylphosphatase-1  
Size: 99 amino acids; 11261 Da
6 PDB 3D structures from and Proteopedia for ACYP1:
2K7J (3D)        2K7K (3D)        2VH7 (3D)        2W4C (3D)        2W4P (3D)        3TOQ (3D)    
Secondary accessions: A6NDV8 B2R590
Alternative splicing: 2 isoforms:  P07311-1   P07311-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ACYP1: NX_P07311

Explore proteomics data for ACYP1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P07311

  • ACYP1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ACYP1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001098.1  NP_982355.1  

    ENSEMBL proteins: 
     ENSP00000238618   ENSP00000450873   ENSP00000350655   ENSP00000451581   ENSP00000452249  
     ENSP00000451220  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR001792 Acylphosphatase-like
     IPR020456 Acylphosphatase
     IPR017968 Acylphosphatase_CS

    Graphical View of Domain Structure for InterPro Entry P07311

    ProtoNet protein and cluster: P07311

    1 Blocks protein domain: IPB001792 Acylphosphatase

    UniProtKB/Swiss-Prot: ACYP1_HUMAN, P07311
    Similarity: Belongs to the acylphosphatase family
    Similarity: Contains 1 acylphosphatase-like domain


    ACYP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ACYP1_HUMAN, P07311
    Function: Its physiological role is not yet clear
    Catalytic activity: An acylphosphate + H(2)O = a carboxylate + phosphate

         Genatlas biochemistry entry for ACYP1:
    acylphosphatase 1erythrocyte (common) type,11kDa

         Enzyme Number (IUBMB): EC 3.6.1.71

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003998acylphosphatase activity IBA--
         
    ACYP1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ACYP1:
     Decreased focal adhesion (FA)  

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ACYP1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ACYP1

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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ACYP1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Naphthalene metabolism
    Naphthalene metabolism0.32
    2Purine metabolism
    ATP/ITP metabolism0.31
    3Pyruvate metabolism
    Pyruvate metabolism

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for ACYP1
        Naphthalene metabolism
    ATP/ITP metabolism


    2 GeneGo (Thomson Reuters) Pathways for ACYP1
        Naphthalene metabolism
    ATP/ITP metabolism



    1         Kegg Pathway  (Kegg details for ACYP1):
        Pyruvate metabolism


    ACYP1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ACYP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/10 Interacting proteins for ACYP1 (ENSP000002386184) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACSS2ENSP000003538044STRING: ENSP00000353804
    ALDH9A1ENSP000003468274STRING: ENSP00000346827
    ACOT12ENSP000003032464STRING: ENSP00000303246
    ACSS1ENSP000003169244STRING: ENSP00000316924
    ALDH1B1ENSP000003669274STRING: ENSP00000366927
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006796phosphate-containing compound metabolic process TAS3026468

    ACYP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ACYP1

    10/16 HMDB Compounds for ACYP1 (see all 16)    About this table
    CompoundSynonyms CAS #PubMed Ids
    3-Phosphoglyceric acid3-(dihydrogen phosphate)Glycerate (see all 21)820-11-1--
    Acetic acidAcetate (see all 12)64-19-7--
    AcetylphosphateAcetylphosphate (see all 4)590-54-5--
    Arachidic acidArachate (see all 10)506-30-9--
    Arachidonic acid5,8,11,14-Eicosatetraenoic acid (see all 16)506-32-1--
    Benzoic acidBenzenecarboxylate (see all 22)65-85-0--
    Glyceric acid 1,3-biphosphate1,3-Biphosphoglycerate (see all 25)1981-49-3--
    Heptadecanoic acidHeptadecanoate (see all 16)506-12-7--
    Heptadecanoyl CoAHeptadecanoyl coenzyme A (see all 19)3546-17-6--
    Myristic acid1-Tridecanecarboxylate (see all 15)544-63-8--

    Search CenterWatch for drugs/clinical trials and news about ACYP1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ACYP1 gene (2 alternative transcripts): 
    NM_001107.3  NM_203488.1  

    Unigene Cluster for ACYP1:

    Acylphosphatase 1, erythrocyte (common) type
    Hs.18573  [show with all ESTs]
    Unigene Representative Sequence: BE777513
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000238618(uc001xrg.3) ENST00000555463 ENST00000357971(uc001xrf.3)
    ENST00000555694 ENST00000555135 ENST00000553302
    miRNA
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    Additional mRNA sequence: 

    AK312101.1 BC035568.1 X84194.1 

    8 DOTS entries:

    DT.92420894  DT.100010212  DT.86845522  DT.120731108  DT.95262502  DT.99982686  DT.100714655  DT.87009894 

    24/82 AceView cDNA sequences (see all 82):

    R57130 AA609308 BX104912 R94465 NM_001107 AA279554 NM_203488 BI712602 
    BC035568 AI271567 AA922113 BM718591 AI216106 AI051114 AA279555 AA022534 
    AI963747 BI712846 BQ776048 BU743031 BE467248 CB305744 AA234590 AV752519 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ACYP1    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b
    SP1:                                -           -               
    SP2:                                -                           
    SP3:                                -     -     -               
    SP4:                    -           -     -     -               
    SP5:                                                            


    ECgene alternative splicing isoforms for ACYP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ACYP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCAGAAGGAA
    ACYP1 Expression
    About this image


    See ACYP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ACYP1

    SOURCE GeneReport for Unigene cluster: Hs.18573

    UniProtKB/Swiss-Prot: ACYP1_HUMAN, P07311
    Tissue specificity: Organ-common type isozyme is found in many different tissues

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ACYP1 gene from 5/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Acyp11 , 5 acylphosphatase 1, erythrocyte (common) type1, 5 85.86(n)1
    90.91(a)1
      12 (39.62 cM)5
    662041  NM_025421.21  NP_079697.11 
     852723985 
    chicken
    (Gallus gallus)
    Aves ACYP11 acylphosphatase 1, erythrocyte (common) type 63.3(n)
    62.63(a)
      423361  NM_001168005.1  NP_001161477.1 
    lizard
    (Anolis carolinensis)
    Reptilia ACYP16
    Acylphosphatase
    68(a)
    1 ↔ 1
    1(22606332-22607526)
    zebrafish
    (Danio rerio)
    Actinopterygii acyp11 acylphosphatase 1, erythrocyte (common) type 66.67(n)
    66.67(a)
      571263  NM_001122849.1  NP_001116321.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Acyp26
    CG183716
    (see all 5)
    --
    39(a)
    36(a)
    (see all 5)
    many → 1
    many → 1
    (see all 5)
    3R(11618461-11619116)
    2R(9916123-9916611)


    ENSEMBL Gene Tree for ACYP1 (if available)
    TreeFam Gene Tree for ACYP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ACYP1 gene
    ACYP22  
    1 SIMAP similar gene for ACYP1 using alignment to 4 protein entries:     ACYP1_HUMAN (see all proteins):
    ACYP2

    ACYP1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/200 SNPs in ACYP1 are shown (see all 200)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2006988751,2
    --75520409(+) GAAAAA/CAAGGT 2 -- int10--------
    rs755695121,2
    C,F--75520456(+) TCAAGC/TCACTG 2 -- int11Minor allele frequency- T:0.06WA 118
    rs1150523181,2
    C,F--75520532(+) TTCACA/GTGAAG 2 -- int11Minor allele frequency- G:0.11WA 118
    rs1389974231,2
    --75520645(+) CAAAAC/GAGATG 2 -- int10--------
    rs1422680011,2
    --75520796(+) TAACCA/GGGACC 2 -- int10--------
    rs1755131,2
    C,F,H--75520806(+) CACACC/GTAAAC 2 -- int116Minor allele frequency- G:0.01EA NA MN WA CSA 496
    rs1447782331,2
    --75520911(+) GTGAAA/GCTGTC 2 -- int10--------
    rs1838626001,2
    --75521326(+) AAATTA/GCTGGA 2 -- int10--------
    rs1889531541,2
    C--75521352(+) CGTTAC/G/TGCATA 2 -- int10--------
    rs1485706791,2
    --75521491(+) AAATTA/GAGGAA 2 -- int10--------

    HapMap Linkage Disequilibrium report for ACYP1 (75519924 - 75536186 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ACYP1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2677383CNV Deletion23128226
    esv29535CNV Loss19812545
    nsv510644CNV Loss20534489

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ACYP1 for disorders           About MalaCards
    OMIM gene information: 600875    OMIM disorders: --


    ACYP1 for disorders           About GeneDecksing


    Export disorders for ACYP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ACYP1 gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with ACYP1)
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    1. Cloning and expression of the cDNA coding for the erythrocyte isoenzyme of human acylphosphatase. (PubMed id 7796909)1, 2, 3 Fiaschi T....Ramponi G. (1995)
    2. Assignment of the human erythrocyte acylphosphatase gene (ACYP1) to chromosome band 14q24.3. (PubMed id 9730610)1, 3, 9 Fiaschi T....Ramponi G. (1998)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)1, 2 Heilig R.... Weissenbach J. (2003)
    5. A new acylphosphatase isoenzyme from human erythrocytes: purification, characterization, and primary structure. (PubMed id 3026468)1, 2 Liguri G....Ramponi G. (1986)
    6. ACYP1 gene possesses two alternative splicing forms that induce apoptosis. (PubMed id 14992377)1, 9 Degl'Innocenti D....Ramponi G. (2004)
    7. Immunoaffinity purification and immunoassay determination of human erythrocyte acylphosphatase. (PubMed id 2169259)1, 9 Degl'Innocenti D....Ramponi G. (1990)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    9. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    10. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 97 HGNC: 179 AceView: ACYP1 Ensembl:ENSG00000119640 euGenes: HUgn97
    ECgene: ACYP1 Kegg: 97 H-InvDB: ACYP1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ACYP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ACYP1 gene:
    Search GeneIP for patents involving ACYP1

    GeneCards and IP:
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