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Aliases for ACYP1 Gene

Aliases for ACYP1 Gene

  • Acylphosphatase 1, Erythrocyte (Common) Type 2 3
  • ACYPE 3 4 6
  • Acylphosphatase, Organ-Common Type Isozyme 3 4
  • Acylphosphatase, Erythrocyte Isozyme 3 4
  • Acylphosphate Phosphohydrolase 1 3 4
  • Acylphosphatase-1 3
  • EC 4

External Ids for ACYP1 Gene

Previous GeneCards Identifiers for ACYP1 Gene

  • GC14M073046
  • GC14M069337
  • GC14M073509
  • GC14M074589
  • GC14M075519
  • GC14M055688

Summaries for ACYP1 Gene

Entrez Gene Summary for ACYP1 Gene

  • This gene is a member of the acylphosphatase family. The encoded protein is a small cytosolic enzyme that catalyzes the hydrolysis of the carboxyl-phosphate bond of acylphosphates. Two isoenzymes have been isolated and described based on their tissue localization: erythrocyte (common) type acylphosphatase encoded by this gene, and muscle type acylphosphatase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

GeneCards Summary for ACYP1 Gene

ACYP1 (Acylphosphatase 1, Erythrocyte (Common) Type) is a Protein Coding gene. Among its related pathways are Pyruvate metabolism and Purine metabolism (KEGG). GO annotations related to this gene include acylphosphatase activity. An important paralog of this gene is ACYP2.

UniProtKB/Swiss-Prot for ACYP1 Gene

  • Its physiological role is not yet clear

Gene Wiki entry for ACYP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACYP1 Gene

Genomics for ACYP1 Gene

Regulatory Elements for ACYP1 Gene

Genomic Location for ACYP1 Gene

75,053,221 bp from pter
75,069,483 bp from pter
16,263 bases
Minus strand

Genomic View for ACYP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ACYP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACYP1 Gene

Proteins for ACYP1 Gene

  • Protein details for ACYP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A6NDV8
    • B2R590

    Protein attributes for ACYP1 Gene

    99 amino acids
    Molecular mass:
    11261 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ACYP1 Gene

    Alternative splice isoforms for ACYP1 Gene


neXtProt entry for ACYP1 Gene

Proteomics data for ACYP1 Gene at MOPED

Post-translational modifications for ACYP1 Gene

  • Ubiquitination at Lys33, Lys58, and Lys89
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for ACYP1 Gene

Domains for ACYP1 Gene

Protein Domains for ACYP1 Gene

Suggested Antigen Peptide Sequences for ACYP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P07311
  • Contains 1 acylphosphatase-like domain.
  • Belongs to the acylphosphatase family.
genes like me logo Genes that share domains with ACYP1: view

No data available for Gene Families for ACYP1 Gene

Function for ACYP1 Gene

Molecular function for ACYP1 Gene

GENATLAS Biochemistry:
acylphosphatase 1erythrocyte (common) type,11kDa
UniProtKB/Swiss-Prot CatalyticActivity:
An acylphosphate + H(2)O = a carboxylate + phosphate
UniProtKB/Swiss-Prot Function:
Its physiological role is not yet clear

Enzyme Numbers (IUBMB) for ACYP1 Gene

Gene Ontology (GO) - Molecular Function for ACYP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003998 acylphosphatase activity IBA --
genes like me logo Genes that share ontologies with ACYP1: view

Phenotypes for ACYP1 Gene

GenomeRNAi human phenotypes for ACYP1:
genes like me logo Genes that share phenotypes with ACYP1: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ACYP1

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ACYP1 Gene

Localization for ACYP1 Gene

Subcellular locations from

Jensen Localization Image for ACYP1 Gene COMPARTMENTS Subcellular localization image for ACYP1 gene
Compartment Confidence
cytosol 3
endoplasmic reticulum 2
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ACYP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with ACYP1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ACYP1 Gene

Pathways for ACYP1 Gene

genes like me logo Genes that share pathways with ACYP1: view

Pathways by source for ACYP1 Gene

1 KEGG pathway for ACYP1 Gene
2 GeneGo (Thomson Reuters) pathways for ACYP1 Gene

Interacting Proteins for ACYP1 Gene

Gene Ontology (GO) - Biological Process for ACYP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006796 phosphate-containing compound metabolic process TAS 3026468
GO:0008152 metabolic process --
genes like me logo Genes that share ontologies with ACYP1: view

Compounds for ACYP1 Gene

(16) HMDB Compounds for ACYP1 Gene

Compound Synonyms Cas Number PubMed IDs
3-Phosphoglyceric acid
  • 3-(dihydrogen phosphate)Glycerate
Acetic acid
  • Acetate
  • Acetylphosphate
Arachidic acid
  • Arachate
Arachidonic acid
  • 5,8,11,14-Eicosatetraenoic acid
genes like me logo Genes that share compounds with ACYP1: view

Transcripts for ACYP1 Gene

Unigene Clusters for ACYP1 Gene

Acylphosphatase 1, erythrocyte (common) type:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ACYP1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ACYP1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b
SP1: - -
SP2: -
SP3: - - -
SP4: - - - -

Relevant External Links for ACYP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ACYP1 Gene

mRNA expression in normal human tissues for ACYP1 Gene

Protein differential expression in normal tissues for ACYP1 Gene

This gene is overexpressed in Tlymphocyte (7.7) and Oral epithelium (7.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ACYP1 Gene

SOURCE GeneReport for Unigene cluster for ACYP1 Gene Hs.18573

mRNA Expression by UniProt/SwissProt for ACYP1 Gene

Tissue specificity: Organ-common type isozyme is found in many different tissues
genes like me logo Genes that share expressions with ACYP1: view

Expression partners for ACYP1 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ACYP1 Gene

Orthologs for ACYP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ACYP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ACYP1 35
  • 89.56 (n)
  • 89.9 (a)
ACYP1 36
  • 88 (a)
(Canis familiaris)
Mammalia ACYP1 35
  • 92.59 (n)
  • 91.92 (a)
ACYP1 36
  • 76 (a)
(Mus musculus)
Mammalia Acyp1 35
  • 85.86 (n)
  • 90.91 (a)
Acyp1 16
Acyp1 36
  • 91 (a)
(Pan troglodytes)
Mammalia ACYP1 35
  • 100 (n)
  • 100 (a)
ACYP1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Acyp1 35
  • 85.86 (n)
  • 87.88 (a)
(Monodelphis domestica)
Mammalia ACYP1 36
  • 81 (a)
(Gallus gallus)
Aves ACYP1 35
  • 63.3 (n)
  • 62.63 (a)
ACYP1 36
  • 63 (a)
(Anolis carolinensis)
Reptilia ACYP1 36
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia acyp1 35
  • 64.29 (n)
  • 70.41 (a)
(Danio rerio)
Actinopterygii acyp1 35
  • 66.67 (n)
  • 66.67 (a)
fruit fly
(Drosophila melanogaster)
Insecta Acyp 36
  • 33 (a)
Acyp2 36
  • 40 (a)
CG11052 36
  • 24 (a)
CG18371 36
  • 37 (a)
CG34161 36
  • 34 (a)
Species with no ortholog for ACYP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ACYP1 Gene

Gene Tree for ACYP1 (if available)
Gene Tree for ACYP1 (if available)

Paralogs for ACYP1 Gene

Paralogs for ACYP1 Gene

Selected SIMAP similar genes for ACYP1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ACYP1: view

Variants for ACYP1 Gene

Sequence variations from dbSNP and Humsavar for ACYP1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs175503 -- 75,066,381(+) ataaa(G/T)ctggG intron-variant
rs175504 -- 75,065,046(+) GTTGA(A/G)TCAGT upstream-variant-2KB, intron-variant
rs175505 -- 75,062,916(+) CATCA(C/T)CTATT intron-variant
rs175506 -- 75,062,223(+) gagcc(C/T)gggag intron-variant
rs175507 -- 75,062,187(+) gcaca(C/T)tggtg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ACYP1 Gene

Variant ID Type Subtype PubMed ID
nsv510644 CNV Loss 20534489
esv2677383 CNV Deletion 23128226
esv29535 CNV Loss 19812545

Relevant External Links for ACYP1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACYP1 Gene

Disorders for ACYP1 Gene

No disorders were found for ACYP1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for ACYP1 Gene

Publications for ACYP1 Gene

  1. Assignment of the human erythrocyte acylphosphatase gene (ACYP1) to chromosome band 14q24.3. (PMID: 9730610) Fiaschi T. … Ramponi G. (Cytogenet. Cell Genet. 1998) 2 3 23
  2. Cloning and expression of the cDNA coding for the erythrocyte isoenzyme of human acylphosphatase. (PMID: 7796909) Fiaschi T. … Ramponi G. (FEBS Lett. 1995) 2 3 4
  3. A new acylphosphatase isoenzyme from human erythrocytes: purification, characterization, and primary structure. (PMID: 3026468) Liguri G. … Ramponi G. (Biochemistry 1986) 3 4
  4. ACYP1 gene possesses two alternative splicing forms that induce apoptosis. (PMID: 14992377) Degl'Innocenti D. … Ramponi G. (IUBMB Life 2004) 3 23
  5. Immunoaffinity purification and immunoassay determination of human erythrocyte acylphosphatase. (PMID: 2169259) Degl'Innocenti D. … Ramponi G. (Biotechnol. Appl. Biochem. 1990) 3 23

Products for ACYP1 Gene

Sources for ACYP1 Gene

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