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Aliases for ACYP1 Gene

Aliases for ACYP1 Gene

  • Acylphosphatase 1 2 3 5
  • Acylphosphatase 1, Erythrocyte (Common) Type 2 3
  • Acylphosphatase, Organ-Common Type Isozyme 3 4
  • Acylphosphatase, Erythrocyte Isozyme 3 4
  • Acylphosphate Phosphohydrolase 1 3 4
  • ACYPE 3 4
  • Acylphosphatase-1 3
  • EC 4

External Ids for ACYP1 Gene

Previous GeneCards Identifiers for ACYP1 Gene

  • GC14M073046
  • GC14M069337
  • GC14M073509
  • GC14M074589
  • GC14M075519
  • GC14M055688

Summaries for ACYP1 Gene

Entrez Gene Summary for ACYP1 Gene

  • This gene is a member of the acylphosphatase family. The encoded protein is a small cytosolic enzyme that catalyzes the hydrolysis of the carboxyl-phosphate bond of acylphosphates. Two isoenzymes have been isolated and described based on their tissue localization: erythrocyte (common) type acylphosphatase encoded by this gene, and muscle type acylphosphatase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

GeneCards Summary for ACYP1 Gene

ACYP1 (Acylphosphatase 1) is a Protein Coding gene. Among its related pathways are Pyrimidine metabolism (KEGG) and Pyruvate metabolism. GO annotations related to this gene include acylphosphatase activity. An important paralog of this gene is ACYP2.

UniProtKB/Swiss-Prot for ACYP1 Gene

  • Its physiological role is not yet clear.

Gene Wiki entry for ACYP1 Gene

Additional gene information for ACYP1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACYP1 Gene

Genomics for ACYP1 Gene

Regulatory Elements for ACYP1 Gene

Enhancers for ACYP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14H074977 1.7 FANTOM5 Ensembl ENCODE dbSUPER 15.7 +87.9 87868 8.3 FOXA2 RAD21 RFX5 FOS RCOR1 EGR2 REST NR2F2 ZNF341 GLIS1 EIF2B2 ACYP1 PGF MLH3 ZC2HC1C RPS6KL1 PROX2 RNU6-689P DLST
GH14H075041 1.1 Ensembl ENCODE 18 +27.5 27525 1.7 ELF3 FOXA2 ARID4B RAD21 RARA YY1 RCOR1 REST PPARG NR2F2 ACYP1 ZC2HC1C PGF MLH3 RNU6-689P
GH14H075273 1.8 FANTOM5 ENCODE dbSUPER 10.9 -208.3 -208338 9.2 HDGF PKNOX1 ARID4B SIN3A ZNF2 ZBTB7B YY1 SLC30A9 ZNF143 ZNF207 FOS GPATCH2L FCF1 NEK9 ACYP1 ENSG00000258559 ENSG00000258740 JDP2 FLVCR2 BATF
GH14H074938 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.2 +128.4 128382 4.6 HDGF BATF GLIS2 ZNF143 ZNF207 FOS ETV6 ATF7 RUNX3 CREM DLST ACYP1 ZC2HC1C EIF2B2 RNU6-689P MLH3 RPS6KL1 GC14P074952
GH14H075123 1 ENCODE dbSUPER 17.3 -54.8 -54816 1.4 ATF1 JUN RFX5 FOSL1 POLR2A FOSL2 FOS ZNF600 SMARCE1 ZNF362 ZC2HC1C EIF2B2 ACYP1 RPS6KL1 JDP2 MLH3 ENSG00000259138 HIF1AP1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ACYP1 on UCSC Golden Path with GeneCards custom track

Promoters for ACYP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Locations for ACYP1 Gene

Genomic Locations for ACYP1 Gene
16,263 bases
Minus strand

Genomic View for ACYP1 Gene

Genes around ACYP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACYP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACYP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACYP1 Gene

Proteins for ACYP1 Gene

  • Protein details for ACYP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A6NDV8
    • B2R590

    Protein attributes for ACYP1 Gene

    99 amino acids
    Molecular mass:
    11261 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ACYP1 Gene

    Alternative splice isoforms for ACYP1 Gene


neXtProt entry for ACYP1 Gene

Post-translational modifications for ACYP1 Gene

  • Ubiquitination at Lys33, posLast=5858, and posLast=8989
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cloud-Clone Corp. Antibodies for ACYP1

No data available for DME Specific Peptides for ACYP1 Gene

Domains & Families for ACYP1 Gene

Gene Families for ACYP1 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for ACYP1 Gene

Suggested Antigen Peptide Sequences for ACYP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the acylphosphatase family.
  • Belongs to the acylphosphatase family.
genes like me logo Genes that share domains with ACYP1: view

Function for ACYP1 Gene

Molecular function for ACYP1 Gene

GENATLAS Biochemistry:
acylphosphatase 1erythrocyte (common) type,11kDa
UniProtKB/Swiss-Prot CatalyticActivity:
An acylphosphate + H(2)O = a carboxylate + phosphate.
UniProtKB/Swiss-Prot Function:
Its physiological role is not yet clear.

Enzyme Numbers (IUBMB) for ACYP1 Gene

Phenotypes From GWAS Catalog for ACYP1 Gene

Gene Ontology (GO) - Molecular Function for ACYP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003998 acylphosphatase activity IBA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with ACYP1: view
genes like me logo Genes that share phenotypes with ACYP1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ACYP1 Gene

Localization for ACYP1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ACYP1 gene
Compartment Confidence
extracellular 5
cytosol 4
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ACYP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with ACYP1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ACYP1 Gene

Pathways & Interactions for ACYP1 Gene

genes like me logo Genes that share pathways with ACYP1: view

Pathways by source for ACYP1 Gene

1 KEGG pathway for ACYP1 Gene
2 GeneGo (Thomson Reuters) pathways for ACYP1 Gene

Interacting Proteins for ACYP1 Gene

Gene Ontology (GO) - Biological Process for ACYP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006796 phosphate-containing compound metabolic process TAS 3026468
genes like me logo Genes that share ontologies with ACYP1: view

No data available for SIGNOR curated interactions for ACYP1 Gene

Drugs & Compounds for ACYP1 Gene

(11) Drugs for ACYP1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Benzoic Acid Approved Pharma 9
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
acetic acid Approved Nutra Full agonist, Agonist 115
3-Phosphoglyceric acid Experimental Pharma 0

(7) Additional Compounds for ACYP1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Arachidic acid
  • Arachate
  • Arachic acid
  • Arachidate
  • Arachidic acid
  • Eicosanoate
Benzoyl phosphate
Glyceric acid 1,3-biphosphate
  • 1,3-Biphosphoglycerate
  • 1,3-Biphosphoglyceric acid
  • 1,3-Bis-phosphoglycerate
  • 1,3-Bisphosphoglycerate
  • 1,3-Diphosphateglycerate
Heptadecanoic acid
  • Heptadecanoate
  • Heptadecanoic acid
  • Margarate
  • Margaric acid
  • Margarinate
Heptadecanoyl CoA
  • Heptadecanoate
  • Heptadecanoic acid
  • Heptadecanoic acid coa
  • Heptadecanoyl coenzyme A
  • Heptadecanoyl-coA
genes like me logo Genes that share compounds with ACYP1: view

Transcripts for ACYP1 Gene

Unigene Clusters for ACYP1 Gene

Acylphosphatase 1, erythrocyte (common) type:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ACYP1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b
SP1: - -
SP2: -
SP3: - - -
SP4: - - - -

Relevant External Links for ACYP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ACYP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ACYP1 Gene

Protein differential expression in normal tissues from HIPED for ACYP1 Gene

This gene is overexpressed in Tlymphocyte (7.7) and Oral epithelium (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ACYP1 Gene

Protein tissue co-expression partners for ACYP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ACYP1 Gene:


SOURCE GeneReport for Unigene cluster for ACYP1 Gene:


mRNA Expression by UniProt/SwissProt for ACYP1 Gene:

Tissue specificity: Organ-common type isozyme is found in many different tissues.
genes like me logo Genes that share expression patterns with ACYP1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ACYP1 Gene

Orthologs for ACYP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ACYP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ACYP1 33 34
  • 100 (n)
(Canis familiaris)
Mammalia ACYP1 34 33
  • 92.59 (n)
(Bos Taurus)
Mammalia ACYP1 33 34
  • 89.56 (n)
(Mus musculus)
Mammalia Acyp1 33 16 34
  • 85.86 (n)
(Rattus norvegicus)
Mammalia Acyp1 33
  • 85.86 (n)
(Monodelphis domestica)
Mammalia ACYP1 34
  • 81 (a)
(Gallus gallus)
Aves ACYP1 33 34
  • 63.3 (n)
(Anolis carolinensis)
Reptilia ACYP1 34
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia acyp1 33
  • 64.29 (n)
(Danio rerio)
Actinopterygii acyp1 33
  • 66.67 (n)
fruit fly
(Drosophila melanogaster)
Insecta Acyp2 34
  • 40 (a)
CG18371 34
  • 37 (a)
CG34161 34
  • 34 (a)
Acyp 34
  • 33 (a)
CG11052 34
  • 24 (a)
Species where no ortholog for ACYP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ACYP1 Gene

Gene Tree for ACYP1 (if available)
Gene Tree for ACYP1 (if available)

Paralogs for ACYP1 Gene

Paralogs for ACYP1 Gene

(1) SIMAP similar genes for ACYP1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ACYP1: view

Variants for ACYP1 Gene

Sequence variations from dbSNP and Humsavar for ACYP1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000336708 -- 75,070,589(+) TCCAG(C/T)GGTTG intron-variant, upstream-variant-2KB, reference, missense
rs1000554238 -- 75,059,978(+) TTAGT(A/G)TTTAA intron-variant
rs1000750374 -- 75,062,291(+) CTGGG(G/T)GTGGC intron-variant
rs1000993243 -- 75,063,652(+) TGTCC(A/G)TCCTT intron-variant
rs1001045360 -- 75,063,836(+) CATGC(A/C)CGGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ACYP1 Gene

Variant ID Type Subtype PubMed ID
nsv565188 CNV loss 21841781
nsv510644 CNV deletion 20534489
esv3634953 CNV loss 21293372
esv3551775 CNV deletion 23714750
esv29535 CNV loss 19812545
esv2677383 CNV deletion 23128226
dgv3781n54 CNV loss 21841781
dgv3780n54 CNV loss 21841781
dgv3779n54 CNV loss 21841781
dgv3778n54 CNV loss 21841781
dgv1103n106 CNV deletion 24896259

Variation tolerance for ACYP1 Gene

Residual Variation Intolerance Score: 44.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.38; 76.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ACYP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACYP1 Gene

Disorders for ACYP1 Gene

Relevant External Links for ACYP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ACYP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ACYP1 Gene

Publications for ACYP1 Gene

  1. Assignment of the human erythrocyte acylphosphatase gene (ACYP1) to chromosome band 14q24.3. (PMID: 9730610) Fiaschi T … Ramponi G (Cytogenetics and cell genetics 1998) 2 3 22 60
  2. Cloning and expression of the cDNA coding for the erythrocyte isoenzyme of human acylphosphatase. (PMID: 7796909) Fiaschi T … Ramponi G (FEBS letters 1995) 2 3 4 60
  3. ACYP1 gene possesses two alternative splicing forms that induce apoptosis. (PMID: 14992377) Degl'Innocenti D … Ramponi G (IUBMB life 2004) 3 22 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R … Weissenbach J (Nature 2003) 3 4 60

Products for ACYP1 Gene

Sources for ACYP1 Gene

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