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Aliases for ACY3 Gene

Aliases for ACY3 Gene

  • Aminoacylase 3 2 3
  • Hepatitis C Virus Core-Binding Protein 1 3 4
  • Aspartoacylase (Aminoacylase) 3 2 3
  • HCV Core-Binding Protein 1 3 4
  • Aspartoacylase-2 3 4
  • Aminoacylase-3 3 4
  • Acylase III 3 4
  • ACY-3 3 4
  • HCBP1 3 4
  • N-Acyl-Aromatic-L-Amino Acid Amidohydrolase 2
  • Aspartoacylase (Aminocyclase) 3 3
  • EC 3.5.1.114 4
  • EC 3.5.1.15 63
  • ASPA2 4

External Ids for ACY3 Gene

Previous GeneCards Identifiers for ACY3 Gene

  • GC11M067166
  • GC11M067411
  • GC11M063739

Summaries for ACY3 Gene

GeneCards Summary for ACY3 Gene

ACY3 (Aminoacylase 3) is a Protein Coding gene. Diseases associated with ACY3 include hepatitis c virus. Among its related pathways are Metabolism and Biological oxidations. GO annotations related to this gene include identical protein binding and hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides. An important paralog of this gene is ASPA.

UniProtKB/Swiss-Prot for ACY3 Gene

  • Plays an important role in deacetylating mercapturic acids in kidney proximal tubules. Also acts on N-acetyl-aromatic amino acids (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACY3 Gene

Genomics for ACY3 Gene

Regulatory Elements for ACY3 Gene

Genomic Location for ACY3 Gene

Chromosome:
11
Start:
67,642,555 bp from pter
End:
67,650,807 bp from pter
Size:
8,253 bases
Orientation:
Minus strand

Genomic View for ACY3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ACY3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACY3 Gene

Proteins for ACY3 Gene

  • Protein details for ACY3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96HD9-ACY3_HUMAN
    Recommended name:
    N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming)
    Protein Accession:
    Q96HD9

    Protein attributes for ACY3 Gene

    Size:
    319 amino acids
    Molecular mass:
    35241 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    • Exists as a mixture of homodimers and homotetramer, both catalytically active (By similarity). Interacts with HCV core protein.

neXtProt entry for ACY3 Gene

Proteomics data for ACY3 Gene at MOPED

Selected DME Specific Peptides for ACY3 Gene

Post-translational modifications for ACY3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ACY3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for ACY3 Gene

Protein Domains for ACY3 Gene

Suggested Antigen Peptide Sequences for ACY3 Gene

Graphical View of Domain Structure for InterPro Entry

Q96HD9

UniProtKB/Swiss-Prot:

ACY3_HUMAN :
  • Belongs to the AspA/AstE family. Aspartoacylase subfamily.
Family:
  • Belongs to the AspA/AstE family. Aspartoacylase subfamily.
genes like me logo Genes that share domains with ACY3: view

No data available for Gene Families for ACY3 Gene

Function for ACY3 Gene

Molecular function for ACY3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
An N-acyl-aromatic-L-amino acid + H(2)O = an aromatic-L-amino acid + a carboxylate
UniProtKB/Swiss-Prot CatalyticActivity:
An N-acetyl-L-cysteine-S-conjugate + H(2)O = an L-cysteine-S-conjugate + acetate
UniProtKB/Swiss-Prot Function:
Plays an important role in deacetylating mercapturic acids in kidney proximal tubules. Also acts on N-acetyl-aromatic amino acids (By similarity).

Enzyme Numbers (IUBMB) for ACY3 Gene

Gene Ontology (GO) - Molecular Function for ACY3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0004046 aminoacylase activity ISS --
GO:0005515 protein binding IPI 21516116
GO:0016788 hydrolase activity, acting on ester bonds IEA --
GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides --
genes like me logo Genes that share ontologies with ACY3: view
genes like me logo Genes that share phenotypes with ACY3: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ACY3

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ACY3 Gene

Localization for ACY3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACY3 Gene

Apical cell membrane; Peripheral membrane protein. Cytoplasm. Note=Predominantly localized in the apical membrane of cells in the S1 segment. In the proximal straight tubules (S2 and S3 segments) is expressed diffusely throughout the cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ACY3 Gene COMPARTMENTS Subcellular localization image for ACY3 gene
Compartment Confidence
extracellular 5
cytosol 4
plasma membrane 3

Gene Ontology (GO) - Cellular Components for ACY3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005829 cytosol TAS --
GO:0016020 membrane --
GO:0016324 apical plasma membrane IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with ACY3: view

Pathways & Interactions for ACY3 Gene

genes like me logo Genes that share pathways with ACY3: view

Pathways by source for ACY3 Gene

Gene Ontology (GO) - Biological Process for ACY3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006805 xenobiotic metabolic process TAS --
GO:0008150 biological_process ND --
GO:0008152 metabolic process --
GO:0016032 viral process IEA --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with ACY3: view

No data available for SIGNOR curated interactions for ACY3 Gene

Drugs & Compounds for ACY3 Gene

(8) Drugs for ACY3 Gene - From: HMDB and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Aspartic acid Approved Nutra Target 0
acetic acid Approved Nutra Full agonist, Agonist 80
Formic acid Experimental Pharma 0
MYRISTIC ACID Experimental Pharma 0
Palmitic Acid Experimental Pharma Full agonist, Agonist 20

(7) Additional Compounds for ACY3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Arachidic acid
  • Arachate
  • Arachic acid
  • Arachidate
  • Arachidic acid
  • Eicosanoate
506-30-9
Heptadecanoic acid
  • Heptadecanoate
  • Heptadecanoic acid
  • Margarate
  • Margaric acid
  • Margarinate
506-12-7
Heptadecanoyl CoA
  • Heptadecanoate
  • Heptadecanoic acid
  • Heptadecanoic acid coa
  • Heptadecanoyl coenzyme A
  • Heptadecanoyl-coA
3546-17-6
N-Acetyl-L-aspartic acid
  • (2S)-2-acetamidobutanedioate
  • (2S)-2-acetamidobutanedioic acid
  • (S)-2-(acetylamino)butanedioate
  • (S)-2-(acetylamino)butanedioic acid
  • (S)-2-(acetylamino)succinic acid
997-55-7
N-Formyl-L-aspartate
genes like me logo Genes that share compounds with ACY3: view

Transcripts for ACY3 Gene

Unigene Clusters for ACY3 Gene

Aspartoacylase (aminocyclase) 3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ACY3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ACY3 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
SP1:
SP2: - -
SP3:

Relevant External Links for ACY3 Gene

GeneLoc Exon Structure for
ACY3
ECgene alternative splicing isoforms for
ACY3

Expression for ACY3 Gene

mRNA expression in normal human tissues for ACY3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ACY3 Gene

This gene is overexpressed in Kidney - Cortex (x17.0), Liver (x6.8), Small Intestine - Terminal Ileum (x6.3), and Pancreas (x4.6).

Protein differential expression in normal tissues from HIPED for ACY3 Gene

This gene is overexpressed in Kidney (40.4), Pancreatic juice (10.1), and Fetal gut (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ACY3 Gene



SOURCE GeneReport for Unigene cluster for ACY3 Gene Hs.126265

genes like me logo Genes that share expression patterns with ACY3: view

Protein tissue co-expression partners for ACY3 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ACY3 Gene

Orthologs for ACY3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ACY3 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Acy3 35
  • 77.14 (n)
  • 70.19 (a)
Acy3 16
Acy3 36
  • 69 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ACY3 35
  • 99.27 (n)
  • 99.37 (a)
ACY3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Acy3 35
  • 76.11 (n)
  • 69.75 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia ACY3 36
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ACY3 36
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia acy3 35
  • 56.72 (n)
  • 52.54 (a)
zebrafish
(Danio rerio)
Actinopterygii acy3.1 35
  • 52.73 (n)
  • 46.49 (a)
acy3.1 36
  • 10 (a)
OneToMany
acy3.2 36
  • 22 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7431 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
OneToMany
Species with no ortholog for ACY3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ACY3 Gene

ENSEMBL:
Gene Tree for ACY3 (if available)
TreeFam:
Gene Tree for ACY3 (if available)

Paralogs for ACY3 Gene

Paralogs for ACY3 Gene

(2) SIMAP similar genes for ACY3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ACY3: view

Variants for ACY3 Gene

Sequence variations from dbSNP and Humsavar for ACY3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs948444 -- 67,646,775(+) CCAAC(C/T)GCCTG intron-variant, utr-variant-5-prime
rs948445 - 67,647,021(+) GCTCC(C/T)GGGGC missense, reference, splice-acceptor-variant, upstream-variant-2KB
rs948446 -- 67,649,167(+) GTTCC(C/T)TCCTT intron-variant
rs1111928 -- 67,649,137(+) GTCAG(C/T)AGAGG intron-variant
rs1871038 -- 67,650,041(-) TCACA(C/G)GGTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ACY3 Gene

Variant ID Type Subtype PubMed ID
nsv897801 CNV Loss 21882294
dgv1194n71 CNV Loss 21882294
esv2422195 CNV Duplication 17116639
dgv1196n71 CNV Loss 21882294
nsv468606 CNV Gain 19166990
dgv1197n71 CNV Loss 21882294
dgv154n27 CNV Loss 19166990
dgv1198n71 CNV Loss 21882294
dgv1199n71 CNV Loss 21882294
nsv468609 CNV Loss 19166990
nsv469963 CNV Loss 18288195
nsv897826 CNV Loss 21882294

Variation tolerance for ACY3 Gene

Residual Variation Intolerance Score: 62.26% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.95; 36.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ACY3 Gene

HapMap Linkage Disequilibrium report
ACY3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACY3 Gene

Disorders for ACY3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ACY3 Gene - From: GeneCards

Disorder Aliases PubMed IDs
hepatitis c virus
  • hepatitic c virus
- elite association
Search ACY3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ACY3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ACY3
genes like me logo Genes that share disorders with ACY3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ACY3 Gene

Publications for ACY3 Gene

  1. How many drug targets are there? (PMID: 17139284) Overington J.P. … Hopkins A.L. (Nat Rev Drug Discov 2006) 25 26
  2. Drugs, their targets and the nature and number of drug targets. (PMID: 17016423) Imming P. … Meyer A. (Nat Rev Drug Discov 2006) 25 26
  3. Structural characterization, tissue distribution, and functional expression of murine aminoacylase III. (PMID: 14656720) Pushkin A. … Kurtz I. (Am. J. Physiol., Cell Physiol. 2004) 2 67
  4. Genetic determinants influencing human serum metabolome among African Americans. (PMID: 24625756) Yu B. … Boerwinkle E. (PLoS Genet. 2014) 67
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 67

Products for ACY3 Gene

Sources for ACY3 Gene

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