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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ACY3 Gene

protein-coding   GIFtS: 55
GCID: GC11M067411

aspartoacylase (aminocyclase) 3

 Explore 2 diseases affiliated with
ACY3 via our new
 Human Malady Compendium 
Biological research products
for ACY3
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Aspartoacylase (Aminocyclase) 31 2     Aminoacylase-33
ACY-31 2 3     Aspartoacylase-21
HCBP11 2 3     ASPA23
Acylase III2 3     Aminoacylase-33
Hepatitis C Virus Core-Binding Protein 12 3     EC 3.5.1.-3
HCV Core-Binding Protein 12 3     EC 3.5.1.158
MGC97401     

External Ids:    HGNC: 241041   Entrez Gene: 917032   Ensembl: ENSG000001327447   OMIM: 6144135   UniProtKB: Q96HD93   

Export aliases for ACY3 gene to outside databases

Previous GC identifers: GC11M067166 GC11M063739


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ACY3_HUMAN, Q96HD9
Function: Plays an important role in deacetylating mercapturic acids in kidney proximal tubules (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_167190.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ACY3 gene promoter:
         Pax-5   MyoD   Lmo2   Roaz   E47   PPAR-alpha   Hand1   NF-kappaB1   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidACY3 promoter sequence
   Search SABiosciences Chromatin IP Primers for ACY3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ACY3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.2   Ensembl cytogenetic band:  11q13.2   HGNC cytogenetic band: 11q13

ACY3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ACY3 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M067411:  view genomic region     (about GC identifiers)

Start:
67,410,026 bp from pter      End:
67,418,130 bp from pter
Size:
8,105 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ACY3_HUMAN, Q96HD9 (See protein sequence)
Recommended Name: Aspartoacylase-2  
Size: 319 amino acids; 35241 Da
Cofactor: Binds 1 zinc ion per subunit (Potential)
Subunit: Homotetramer (By similarity). Interacts with HCV core protein
Subcellular location: Apical cell membrane; Peripheral membrane protein. Cytoplasm. Note=Predominantly localized in the
apical membrane of cells in the S1 segment. In the proximal straight tubules (S2 and S3 segments) is expressed
diffusely throughout the cytoplasm

Explore the universe of human proteins at neXtProt for ACY3: NX_Q96HD9

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96HD9

  • 4/5 DME Specific Peptides for ACY3 (Q96HD9) (see all 5)
     GPQPQGV  FINEAAY  GGTHGNE  NEAAYYEK 

    ACY3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_542389.1  
    ENSEMBL proteins: 
     ENSP00000255082   ENSP00000434270  

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    ProSpec Recombinant Protein for ACY3
    Uscn Proteins for ACY3

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005624membrane fraction ----
    GO:0005737cytoplasm IEA--
    GO:0016324apical plasma membrane IEA--


    ACY3 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ACY3 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR007036 Aste_AspA
     IPR016708 Aspartoacylase

    Graphical View of Domain Structure for InterPro Entry Q96HD9

    ProtoNet protein and cluster: Q96HD9

    1 Blocks protein family: IPB007036 Succinylglutamate desuccinylase/aspartoacylase

    UniProtKB/Swiss-Prot: ACY3_HUMAN, Q96HD9
    Similarity: Belongs to the AspA/AstE family. Aspartoacylase subfamily


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: ACY3_HUMAN, Q96HD9
    Function: Plays an important role in deacetylating mercapturic acids in kidney proximal tubules (By similarity)

    Enzyme Numbers (IUBMB): EC 3.5.1.-1 EC 3.5.1.152

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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004046aminoacylase activity IEA--
    GO:0016788hydrolase activity, acting on ester bonds IEA--
    GO:0042802identical protein binding IEA--
    GO:0046872metal ion binding IEA--


    ACY3 for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Alanine, aspartate and glutamate metabolism
    Alanine, aspartate and glutamate metabolism1.00
    2Histidine metabolism
    Histidine metabolism1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    2         Kegg Pathways  (Kegg details for ACY3):
        Alanine, aspartate and glutamate metabolism
    Histidine metabolism


    ACY3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ACY3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/31 Interacting proteins for ACY3 (Q96HD93 ENSP000002550824) via UniProtKB, MINT, STRING, and/or I2D (see all 31)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GORASP2Q9H8Y83I2D: score=1 
    ADSSENSP000003554934STRING: ENSP00000355493
    ADSSL1ENSP000003330194STRING: ENSP00000333019
    ASNSENSP000001755064STRING: ENSP00000175506
    ASS1ENSP000002530044STRING: ENSP00000253004
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0019048virus-host interaction IEA--
    GO:0044419interspecies interaction between organisms ----


    ACY3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ACY3

    10/14 HMDB Compounds for ACY3 (see all 14)    About this table
    CompoundSynonyms CAS #PubMed Ids
    Acetic acidAcetate (see all 12)64-19-7--
    Arachidic acidArachate (see all 10)506-30-9--
    Arachidonic acid5,8,11,14-Eicosatetraenoic acid (see all 16)506-32-1--
    Formic acidAdd-F (see all 21)64-18-6--
    Heptadecanoic acidHeptadecanoate (see all 16)506-12-7--
    Heptadecanoyl CoAHeptadecanoyl coenzyme A (see all 19)3546-17-6--
    L-Aspartic acid(+)-Aspartate (see all 41)56-84-8--
    Myristic acid1-Tridecanecarboxylate (see all 15)544-63-8--
    N-Acetyl-L-aspartic acid(2S)-2-acetamidobutanedioic acid (see all 18)997-55-7--
    Palmitic acidHexaectylic acid (see all 45)57-10-3--

    1 DrugBank Compound for ACY3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Aspartic Acid(+)-Aspartic acid (see all 23)56-84-8target--17139284 17016423

    Search CenterWatch for drugs/clinical trials and news about ACY3 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ACY3 gene: 
    NM_080658.1  

    Unigene Cluster for ACY3:

    Aspartoacylase (aminocyclase) 3
    Hs.126265  [show with all ESTs]
    Unigene Representative Sequence: BC008689
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000255082(uc001omq.3) ENST00000529256

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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ACY3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ACY3

    Additional cDNA sequence: 

    AF359506.1 AK308710.1 AY032593.1 AY040761.1 AY169233.1 BC008689.1 

    3 DOTS entries:

    DT.106820  DT.100751214  DT.95363314 

    24/34 AceView cDNA sequences (see all 34):

    BC008689 BX099342 AY169233 CB142925 NM_080658 AI984323 AY040761 BQ066416 
    BM923441 AA912995 AI651548 BI762818 BI762689 BP346760 CB131482 BE870188 
    AA873854 R55423 AI949904 AI393205 AI480405 BE501441 AI478333 AW205296 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ACY3    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
    SP1:                                                                        
    SP2:                    -     -                                             
    SP3:                                                                        


    ECgene alternative splicing isoforms for ACY3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ACY3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTCCTTGCCA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See ACY3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ACY3

    SOURCE GeneReport for Unigene cluster: Hs.126265
        SABiosciences Custom PCR Arrays for ACY3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACY3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ACY3 gene from 2/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia ACY36
    --
    57(a)
    1 ↔ 1
    1(93381970-93387571)
    zebrafish
    (Danio rerio)
    Actinopterygii acy3.11 aspartoacylase (aminocyclase) 3.1 52.84(n)
    46.49(a)
      791456  NM_001145361.1  NP_001138833.1 


    ENSEMBL Gene Tree for ACY3 (if available)
    TreeFam Gene Tree for ACY3 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ACY3 gene
    ASPA2  
    2 SIMAP similar genes for ACY3 using alignment to 2 protein entries:     ACY3_HUMAN (see all proteins):
    HCBP1    ASPA

    ACY3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/294 NCBI SNPs in ACY3 are shown (see all 294    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1126844221,2
    --67409698(+) GCCTGT/ACTCTG 1 -- int12Minor allele frequency- A:0.04CSA WA 120
    rs1456067891,2
    --67409704(+) CTCTGC/TGCTCC 1 -- int10--------
    rs349174031,2
    C,--67409719(+) ACTCA-/CTGT  
            
    CTGGC
    1 -- int10--------
    rs1112291021,2
    --67409753(+) GGGGGG/TTCCCC 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs1426580251,2
    --67409828(+) TCCTCC/TCACAC 1 -- int10--------
    rs1899052791,2
    --67409911(+) TGCAGG/TTCCAA 1 -- int10--------
    rs1150441421,2
    F,--67410026(+) GGACCT/ACTGGA 1 -- ut311Minor allele frequency- A:0.09WA 118
    rs22909601,2
    C,F,H,--67410074(-) CCTCCC/TCAACC 1 -- ut31 ese312Minor allele frequency- T:0.04EA NA NS 2544
    rs1457167891,2
    --67410080(+) GGAGGC/TCTGGC 1 -- ut310--------
    rs1813001641,2
    --67410132(+) GCTCAG/TAGCTG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ACY3 (67410026 - 67418130 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for ACY3
         2 CNVs: 53128 5275

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ACY3 for disorders           About GeneDecksing

    OMIM gene information: 614413    OMIM disorders: --

    2 diseases for ACY3:    About MalaCards
    hepatitis c    hepatitis

    1 disease from the University of Copenhagen DISEASES database for ACY3:
    Canavan disease

    Export disorders for ACY3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ACY3 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ACY3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a novel protein binding to hepatitis C virus core protein. (PubMed id 19486448)1, 2 Chen Y.R.... Liu M. (2009)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Structural characterization, tissue distribution, and functional expression of murine aminoacylase III. (PubMed id 14656720)1, 3 Pushkin A....Kurtz I. (2004)
    4. Identification of NPC2 protein as interaction molecul e with C2 domain of human Nedd4L. (PubMed id 19664597)1 Araki N....Umemura S. (2009)
    5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    6. Drugs, their targets and the nature and number of dru g targets. (PubMed id 17016423)7 Imming P....Meyer A. (2006)
    7. How many drug targets are there? (PubMed id 17139284)7 Overington J.P....Hopkins A.L. (2006)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    9. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 91703 HGNC: 24104 AceView: ACY3 Ensembl:ENSG00000132744 euGenes: HUgn91703
    ECgene: ACY3 Kegg: 91703 H-InvDB: ACY3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ACY3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ACY3 gene:
    Search GeneIP for patents involving ACY3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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