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Aliases & Descriptions for ACVR2B
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| ACTR-IIB 3 | | ACTRIIB 2, 5 | | ActR-IIB 1, 2 | | EC 2.7.11.30 3 | | MGC116908 2 |
| | | Descriptions |
|---|
| Activin receptor type IIB 3 | | activin A receptor, type IIB 2 | | activin A type IIB receptor 2 |
|
| | Search outside databases for aliases for ACVR2B genePrevious GC identifers: GC03P037785 GC03P038309 GC03P038456 |
Summaries for ACVR2B(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for ACVR2B: Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. [provided by RefSeq] UniProtKB/Swiss-Prot: AVR2B_HUMAN, Q13705Function: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin AGene Wiki entry for ACVR2B |
Genomic Location for ACVR2B
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the ACVR2B gene 
Entrez Gene cytogenetic band: 3p22 Ensembl cytogenetic band: 3p22.2 HGNC cytogenetic band: 3p22ACVR2B Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P038470:
(about GC identifiers)
Start:
|
38,470,794 bp from pter |
End:
|
38,509,637 bp from pter |
Size:
|
38,844 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000003.10 NT_022517.17
| Proteins for ACVR2B
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: AVR2B_HUMAN, Q13705 (See
protein sequence)Recommended Name: Activin receptor type-2B precursor Size: 512 amino acids; 57724 Da
Cofactor: Magnesium or manganese (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
PDB structure from and Proteopedia :2H62 (3D)
 2QLU (3D)
 
Secondary accessions: Q4VAV0Alternative splicing: 2 isoforms: Q13705-1 Q13705-2 REFSEQ proteins: NP_001097.2
ENSEMBL proteins: ENSP00000340361
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
4 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for ACVR2B: Assays for ACVR2B: | Protein
Domains/ Families for ACVR2B(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q13705
ProtoNet protein and cluster: Q13705 2 Blocks protein families: IPB000333 Activin type II receptor signature IPB000472 Domain in TGF-beta receptor/activin receptor
UniProtKB/Swiss-Prot: AVR2B_HUMAN, Q13705Similarity: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamilySimilarity: Contains 1 protein kinase domain | Gene Function for ACVR2B
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001106
Applied Biosystems Silencer® siRNAs for ACVR2B
Sigma-Aldrich siRNA and siRNA Panels for ACVR2B  Sigma-Aldrich shRNA Panels and shRNA for ACVR2B  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001106                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_001106                                  untagged cDNA clone in CMV expression vector: NM_001106 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_001106
UniProtKB/Swiss-Prot: AVR2B_HUMAN, Q13705Function: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin ACatalytic activity: ATP + [receptor-protein] = ADP + [receptor-protein] phosphateEnzyme Number (IUBMB): EC 2.7.11.30 Genatlas biochemistry entry for ACVR2B:activin A receptor,type IIB,stimulating FSH secretion,TGF beta superfamily12 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Acvr2b):
5/8 Gene Ontology (GO) molecular function terms (links to tree view) (see all 8
): About this table | Pathways & Interactions for ACVR2B
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
4 Sigma-Aldrich "Your Favorite Gene" Pathways for ACVR2B (Your Favorite Gene powered by Ingenuity) 
Gene Network CentralTM Interacting Genes and Proteins Network for ACVR2B 
5/55 Interacting proteins for ACVR2B (ENSP000003403613) via UniProtKB, MINT, and/or STRING (see all 55
)About this table
5/8 Gene Ontology (GO) biological process terms (links to tree view) (see all 8
): About this table
|
Drugs & Compounds for ACVR2B(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for ACVR2B 1 Novoseek chemical compound relationship for ACVR2B gene
About this table
|
Transcripts for ACVR2B(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001106
Sigma-Aldrich siRNA and siRNA Panels for ACVR2B  Sigma-Aldrich shRNA Panels and shRNA for ACVR2B  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_001106 REFSEQ mRNAs for ACVR2B gene: NM_001106.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001106               OriGene GFP tagged cDNA clone in CMV expression vector: NM_001106                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_001106                                  untagged cDNA clone in CMV expression vector: NM_001106  Additional cDNA sequence: AF075005.1 BC096243.1 BC096244.1 BC096245.1 BC099642.4 X77533.1 7 DOTS entries: DT.112110 DT.101972686 DT.120906411 DT.108649 DT.120906415 DT.95357406 DT.40128877 24 AceView cDNA sequences:CA449586 AF075005 BM681447 AA584783 AI337218 AW206608 BP352716 NM_001106 X77533 BE733986 BM727806 AI143544 BF592947 CF141438 BE732193 AI247855 AA226002 BE857424 T54133 R68237 N84806 T54229 R82487 R26777
highest scoring ESTs for ACVR2B:X77533 AF075005 AI143544 AI247855 AI337218 AW206608 BF592947 R26777 R68237 R82487 Unigene Cluster for ACVR2B: Activin A receptor, type IIB Hs.174273 [show with all ESTs]Unigene Representative Sequence: NM_001106
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for ACVR2B
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for ACVR2B
1 Ensembl transcript including schematic representation: ENST00000352511
|
Expression for ACVR2B
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| ACVR2B expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for ACVR2B
1 / 2 / 3 8 probe-sets matching ACVR2B gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TAATTACAGT
SOURCE GeneReport for Unigene cluster: Hs.174273
Expression variation in blood from EXPOLDB for ACVR2B |
Orthologs for ACVR2B
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for ACVR2B gene from 5/11 species (see all 11
)
About this table Species with no ortholog for ACVR2B
ENSEMBL Gene Tree for ACVR2B | Paralogs for ACVR2B(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for ACVR2B gene
- TGFBR22 ACVR2A2
|
SNPs/Variants for ACVR2B(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for ACVR2B (up to first 250kb)
|
Disorders & Mutations for ACVR2B
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 602730 UniProtKB/Swiss-Prot: AVR2B_HUMAN, Q13705
Defects in ACVR2B are a cause of left-right axis malformations [MIM:602730]. Th effect is due to the loss of normal left-right asymmetry. Complete left-right asymmetry reversal imparts no deleterious consequences to the affected individual, whereas randomization typically results in complex, often lethal heart malformations as well as abdominal abnormalities3 Novoseek disease relationships for ACVR2B gene
About this table
Human Gene Mutation Database: ACVR2B Genetic Association Database: ACVR2B
|
Medical News for ACVR2B(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for ACVR2B (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/110 PubMed articles for ACVR2B gene (see all 110
):- Left-right axis malformations associated with mutations in ACVR2B, the gene for human activin receptor type IIB. (PubMed id 9916847)1, 3, 4, 6 Kosaki R....Casey B. (1999)
- Genomic organization and mapping of the human activin receptor type IIB (hActR-IIB) gene. (PubMed id 9621519)1, 2, 3, 4 Ishikawa S....Nakamura Y. (1998)
- Expression of type II activin receptor genes during differentiation of human K562 cells and cDNA cloning of the human type IIB activin receptor. (PubMed id 8161782)1, 2, 3, 4 Hilden K.... Ritvos O. (1994)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Crystal structure of activin receptor type IIB kinase domain from human at 2.0 Angstrom resolution. (PubMed id 17893364)1, 3 Han S....Xie Z. (2007)
- Activation of signalling by the activin receptor complex. (PubMed id 8622651)1, 3 Attisano L....Massague J. (1996)
- Bone morphogenetic proteins. (PubMed id 15621726)1, 3 Chen D....Mundy G.R. (2004)
- Myostatin signals through a transforming growth factor beta-like signaling pathway to block adipogenesis. (PubMed id 14517293)1, 3 Rebbapragada A....Attisano L. (2003)
- Identification of type I and type II serine/threonine kinase receptors for growth/differentiation factor-5. (PubMed id 8702914)1, 3 Nishitoh H....Miyazono K. (1996)
- Expression of activin subunits and receptors in the developing human ovary: activin A promotes germ cell survival and proliferation before primordial follicle formation. (PubMed id 14738881)1, 3 Martins da Silva S.J....Anderson R.A. (2004)
|
Search for ACVR2B
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing ACVR2B
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing ACVR2B
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ACVR2B(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for ACVR2B(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for ACVR2B:

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Incremental update: 13 Oct 2009
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