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ACVR2B Gene

protein-coding GIFtS: 66

GC03P038470

activin A receptor, type IIB
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
ACTR-IIB ^³
ACTRIIB ^², ⁵
ActR-IIB ^¹, ²
EC 2.7.11.30 ^³
MGC116908 ^²

Descriptions
Activin receptor type IIB ^³
activin A receptor, type IIB ^²
activin A type IIB receptor ^²

External Ids
HGNC: 174¹
Entrez Gene: 93²
UniProtKB: Q13705³
Ensembl: ENSG00000114739⁷

Search outside databases for aliases for ACVR2B gene

Previous GC identifers: GC03P037785 GC03P038309 GC03P038456

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ACVR2B:

Activins are dimeric growth and differentiation factors which belong to the transforming growth

factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal

through a heteromeric complex of receptor serine kinases which include at least two type I (I and

IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins,

composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane

domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are

essential for signaling; and type II receptors are required for binding ligands and for expression

of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting

in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to

be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a

3- to 4-fold higher affinity for the ligand than activin A type II receptor. [provided by RefSeq]

UniProtKB/Swiss-Prot: AVR2B_HUMAN, Q13705

Function: On ligand binding, forms a receptor complex consisting of two type II and two type I

transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I

receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators.

Receptor for activin A, activin B and inhibin A

Gene Wiki entry for ACVR2B

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ACVR2B gene

Entrez Gene cytogenetic band: 3p22 Ensembl cytogenetic band: 3p22.2 HGNC cytogenetic band: 3p22

ACVR2B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03P038470: (about GC identifiers)

Start:	38,470,794 bp from pter
End:	38,509,637 bp from pter
Size:	38,844 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000003.10 NT_022517.17

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: AVR2B_HUMAN, Q13705 (See protein sequence)

Recommended Name: Activin receptor type-2B precursor

Size: 512 amino acids; 57724 Da

Cofactor: Magnesium or manganese (By similarity)

Subcellular location: Membrane; Single-pass type I membrane protein

PDB structure from and Proteopedia :

2H62 (3D)

2QLU (3D)

Secondary accessions: Q4VAV0

Alternative splicing: 2 isoforms: Q13705-1 Q13705-2

REFSEQ proteins: NP_001097.2

ENSEMBL proteins:

ENSP00000340361

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for ACVR2B (Activin RIIB)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Activin Receptor Type IIB)
	Human Recombinant Proteins from Abnova (ACVR2B)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IDA	14738881
GO:0005886	plasma membrane	EXP	17356069
GO:0005887	integral to plasma membrane	TAS	8161782
GO:0009986	cell surface	IDA	12493773

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Antibodies for ACVR2B:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for ACVR2B
	R&D Systems Antibodies for ACVR2B (Activin RIIB)
	Antibodies from Abcam (Activin Receptor Type IIB), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ACVR2B)
	Novus Biologicals Antibodies for ACVR2B

Assays for ACVR2B:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q13705

ProtoNet protein and cluster: Q13705

2 Blocks protein families:

IPB000333 Activin type II receptor signature

IPB000472 Domain in TGF-beta receptor/activin receptor

UniProtKB/Swiss-Prot: AVR2B_HUMAN, Q13705

Similarity: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB

receptor subfamily

Similarity: Contains 1 protein kinase domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ACVR2B)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ACVR2B)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001106

Applied Biosystems Silencer® siRNAs for ACVR2B

Sigma-Aldrich siRNA and siRNA Panels for ACVR2B

Sigma-Aldrich shRNA Panels and shRNA for ACVR2B

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ACVR2B
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001106
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001106
untagged cDNA clone in CMV expression vector: NM_001106

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001106

UniProtKB/Swiss-Prot: AVR2B_HUMAN, Q13705

Function: On ligand binding, forms a receptor complex consisting of two type II and two type I

transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I

receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators.

Receptor for activin A, activin B and inhibin A

Catalytic activity: ATP + [receptor-protein] = ADP + [receptor-protein] phosphate

Enzyme Number (IUBMB): EC 2.7.11.30

Genatlas biochemistry entry for ACVR2B:

activin A receptor,type IIB,stimulating FSH secretion,TGF beta superfamily

12 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Acvr2b):

	embryogenesis	growth/size	hematopoietic system	homeostasis/metabolism
immune system	lethality-postnatal	lethality-prenatal/perinatal	liver/biliary system	renal/urinary system
respiratory system	skeleton

5/8 Gene Ontology (GO) molecular function terms (links to tree view) (see all 8 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0000287	magnesium ion binding	IEA	--
GO:0004872	receptor activity	IEA	--
GO:0005524	ATP binding	IEA	--
GO:0016362	contributes to activin receptor activity, type II	TAS	8622651

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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4 Sigma-Aldrich "Your Favorite Gene" Pathways for ACVR2B (Your Favorite Gene powered by Ingenuity)

Factors Promoting Cardiogenesis in Vertebrates
PPAR&alpha
TGF-&beta
Wnt/&beta

GeneDecks ACVR2B for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for ACVR2B

5/55 Interacting proteins for ACVR2B (ENSP00000340361³) via UniProtKB, MINT, and/or STRING (see all 55 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
BMP2	ENSP00000368104³	STRING (score=.997)
INHBE	ENSP00000266646³	STRING (score=.995)
MSTN	ENSP00000260950³	STRING (score=.992)
SMAD4	ENSP00000341551³	STRING (score=.992)
BMPR1A	ENSP00000361107³	STRING (score=.991)

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5/8 Gene Ontology (GO) biological process terms (links to tree view) (see all 8 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006468	protein amino acid phosphorylation	IEA	--
GO:0007165	signal transduction	IDA	8622651
GO:0009952	anterior/posterior pattern formation	IMP	9916847
GO:0030501	positive regulation of bone mineralization	IMP	18436533
GO:0030509	BMP signaling pathway	IDA	18436533

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ACVR2B
1 Novoseek chemical compound relationship for ACVR2B gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
threonine	69.25	6	17893364 (1), 1310075 (1), 10652306 (1), 12665502 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ACVR2B)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ACVR2B)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001106

Sigma-Aldrich siRNA and siRNA Panels for ACVR2B

Sigma-Aldrich shRNA Panels and shRNA for ACVR2B

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001106

REFSEQ mRNAs for ACVR2B gene:

NM_001106.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001106

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001106
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001106
                                 untagged cDNA clone in CMV expression vector: NM_001106

Additional cDNA sequence:

AF075005.1 BC096243.1 BC096244.1 BC096245.1 BC099642.4 X77533.1

7 DOTS entries:

DT.112110 DT.101972686 DT.120906411 DT.108649 DT.120906415 DT.95357406 DT.40128877

24 AceView cDNA sequences:

CA449586 AF075005 BM681447 AA584783 AI337218 AW206608 BP352716 NM_001106

X77533 BE733986 BM727806 AI143544 BF592947 CF141438 BE732193 AI247855

AA226002 BE857424 T54133 R68237 N84806 T54229 R82487 R26777

highest scoring ESTs for ACVR2B:

X77533 AF075005 AI143544 AI247855 AI337218 AW206608 BF592947 R26777 R68237 R82487

Unigene Cluster for ACVR2B:

Activin A receptor, type IIB

Hs.174273 [show with all ESTs]

Unigene Representative Sequence: NM_001106

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for ACVR2B

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11
SP1:
SP2:

About this scheme

ECgene alternative splicing isoforms for ACVR2B

1 Ensembl transcript including schematic representation:

ENST00000352511

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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ACVR2B expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ACVR2B

¹ / ² / ³

8 probe-sets matching ACVR2B gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
39314_at²^{, 3}	U95-A	1	1.00	1.00	0.44	0.53	X77533	1.00	1.00	1.00	1
83180_at²^{, 3}	U95-D	1	1.00	1.00	0.83	0.85	AL121043	0.40	1.00	0.76	1
46395_at²^{, 3}	U95-B	1	1.00	1.00	0.58	1.64	AI032142	0.40	1.00	0.76	1
220028_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_001106	0.60	1.00	0.82	1
236126_at²^{, 3}	U133-B	1	0.91	1.00	--	--	AI188710	0.20	1.00	0.72	1
220028_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
236126_at²	U133Plus2	1	0.91	1.00	--	--	--	--	--	--	--
1559548_at²	U133Plus2	1	0.73	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TAATTACAGT

SOURCE GeneReport for Unigene cluster: Hs.174273
Expression variation in blood from EXPOLDB for ACVR2B

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ACVR2B gene from 5/11 species (see all 11 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ACVR2B¹	--	activin A receptor, type IIB	92.94(n) 99.6(a)	485590 XM_542709.1 XP_542709.1
chimpanzee (Pan troglodytes)	ACVR2B¹	--	activin A receptor, type IIB	99.02(n) 98.83(a)	460271 XM_001171684.1 XP_001171684.1
cow (Bos taurus)	ACVR2B¹	--	activin A receptor, type IIB	92.58(n) 98.44(a)	282131 NM_174495.2 NP_776920.1
rat (Rattus norvegicus)	Acvr2b¹	--	activin A receptor, type IIB	91.6(n) 99.02(a)	25366 NM_031554.1 NP_113742.1
mouse (Mus musculus)	Acvr2b^{1, 5}	9⁵	activin receptor IIB^{1, 5}	92.12(n)¹ 99.41(a)¹	11481¹ NM_007397.2¹ NP_031423.1¹ AK137432⁵ BC106189⁵ (see all 7)

About this table Species with no ortholog for ACVR2B

ENSEMBL Gene Tree for ACVR2B

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ACVR2B gene

TGFBR2² ACVR2A²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/270 NCBI SNPs in ACVR2B are shown (see all 270 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 143)

AB	SNP ID	Valid	Chr 3 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs928813^1,2	A,C,F,H,O	38503541(+)	`GCTGTG/TCTTAG`	1	--	ut3¹		19	NA EA EU WA	1390
	rs6599205^1,2	A,C,F,H	38504444(+)	`GGCCAG/CGCCTG`	1	--	ut3¹		7	EA WA NA	628
	rs11914389^1,2	A,C,F,H	38502219(+)	`TTTTTT/CTTCCC`	1	--	ut3¹		4	EU EA WA	404
	rs11926767^1,2	A,C,F,H	38502917(+)	`AAATGT/CTTGTC`	1	--	ut3¹		11	EU EA WA NA	976
	rs7642472^1,2	A,C,F,H	38500571(+)	`GGAATT/CGAGGG`	1	--	ut3¹		7	NA EU EA WA	558
	rs7640050^1,2	A,C,F,H	38500868(+)	`CCCACA/CGGGGA`	1	--	ut3¹		4	EU EA WA	418
	rs1058945^1,2	C,F,H,O	38507515(+)	`CAGTCG/ACTAAT`	1	--	ut3¹		17	NS MN NA EU EA WA	1262
	rs7374458^1,2	A,C,F,H	38506215(+)	`GTGCCT/GATTGG`	1	--	ut3¹		4	EU EA WA	420
	rs12636077^1,2	C,F,H	38500592(+)	`GTGGAG/AGCCGA`	1	--	ut3¹		7	NA EU EA WA	556
	rs13072731^1,2	F,H	38508339(+)	`CGCAGA/CGTAGA`	1	--	ut3¹		4	EU EA WA	414

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HapMap Linkage Disequilibrium images for ACVR2B (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 602730

UniProtKB/Swiss-Prot: AVR2B_HUMAN, Q13705

Defects in ACVR2B are a cause of left-right axis malformations [MIM:602730]. Th effect is

due to the loss of normal left-right asymmetry. Complete left-right asymmetry reversal imparts no

deleterious consequences to the affected individual, whereas randomization typically results in

complex, often lethal heart malformations as well as abdominal abnormalities

3 Novoseek disease relationships for ACVR2B gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
hypoplasia	15.09	2	11334431 (1)
carcinoma	0.00	1	17121532 (1)
tumors	0.00	2	8636304 (1), 11889215 (1)

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Human Gene Mutation Database: ACVR2B
Genetic Association Database: ACVR2B

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/110 PubMed articles for ACVR2B gene (see all 110 ):

Left-right axis malformations associated with mutations in ACVR2B, the gene for human activin receptor type IIB. (PubMed id 9916847)^{1, 3, 4, 6} Kosaki R....Casey B. (1999)
Genomic organization and mapping of the human activin receptor type IIB (hActR-IIB) gene. (PubMed id 9621519)^{1, 2, 3, 4} Ishikawa S....Nakamura Y. (1998)
Expression of type II activin receptor genes during differentiation of human K562 cells and cDNA cloning of the human type IIB activin receptor. (PubMed id 8161782)^{1, 2, 3, 4} Hilden K.... Ritvos O. (1994)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Crystal structure of activin receptor type IIB kinase domain from human at 2.0 Angstrom resolution. (PubMed id 17893364)^{1, 3} Han S....Xie Z. (2007)
Activation of signalling by the activin receptor complex. (PubMed id 8622651)^{1, 3} Attisano L....Massague J. (1996)
Bone morphogenetic proteins. (PubMed id 15621726)^{1, 3} Chen D....Mundy G.R. (2004)
Myostatin signals through a transforming growth factor beta-like signaling pathway to block adipogenesis. (PubMed id 14517293)^{1, 3} Rebbapragada A....Attisano L. (2003)
Identification of type I and type II serine/threonine kinase receptors for growth/differentiation factor-5. (PubMed id 8702914)^{1, 3} Nishitoh H....Miyazono K. (1996)
Expression of activin subunits and receptors in the developing human ovary: activin A promotes germ cell survival and proliferation before primordial follicle formation. (PubMed id 14738881)^{1, 3} Martins da Silva S.J....Anderson R.A. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 93	HGNC: 174	AceView: ACVR2B	Ensembl:ENSG00000114739	euGenes: HUgn93
ECgene: ACVR2B	H-InvDB: ACVR2B

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for ACVR2B	Genetics and Cytogenetics in Oncology and Haematology
GeneReviews	http://www.genetests.org/query?gene=ACVR2B

Licensable Technologies for ACVR2B
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ACVR2B:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ACVR2B-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ACVR2B		Antibodies for ACVR2B
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ACVR2B		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (ACVR2B)
	Antibodies (ACVR2B)
	Chimera RNAi (ACVR2B)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	Antibodies (Activin Receptor Type IIB)

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Search Tocris compounds for ACVR2B

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for ACVR2B

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
ACVR2B Gene at Home site.
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ACVR2B Gene

protein-coding GIFtS: 66

Aliases &
Descriptions
for ACVR2B

Summaries
for ACVR2B

Genomic Location
for ACVR2B

Proteins
for ACVR2B

Protein Domains/
Families
for ACVR2B

Gene Function
for ACVR2B

Pathways & Interactions
for ACVR2B

Drugs & Compounds
for ACVR2B

Transcripts
for ACVR2B

Expression
for ACVR2B

Orthologs
for ACVR2B

Paralogs
for ACVR2B

SNPs/Variants
for ACVR2B

Disorders & Mutations
for ACVR2B

Medical News
for ACVR2B

Publications
for ACVR2B

Search for ACVR2B

Genome Databases showing ACVR2B

Other Databases showing ACVR2B

Specialized Databases showing ACVR2B

Licensable Technologies
for ACVR2B

Services
for ACVR2B

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ACVR2B Gene

protein-coding GIFtS: 66

Aliases & Descriptionsfor ACVR2B

Summariesfor ACVR2B

Genomic Locationfor ACVR2B

Proteinsfor ACVR2B

Protein Domains/Familiesfor ACVR2B

Gene Functionfor ACVR2B

Pathways & Interactionsfor ACVR2B

Drugs & Compoundsfor ACVR2B

Transcriptsfor ACVR2B

Expression for ACVR2B

Orthologsfor ACVR2B

Paralogsfor ACVR2B

SNPs/Variantsfor ACVR2B

Disorders & Mutationsfor ACVR2B

Medical Newsfor ACVR2B

Publicationsfor ACVR2B

Search for ACVR2B

Genome Databases showing ACVR2B

Other Databases showing ACVR2B

Specialized Databases showing ACVR2B

Licensable Technologiesfor ACVR2B

Servicesfor ACVR2B

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ACVR2B

Summaries
for ACVR2B

Genomic Location
for ACVR2B

Proteins
for ACVR2B

Protein Domains/
Families
for ACVR2B

Gene Function
for ACVR2B

Pathways & Interactions
for ACVR2B

Drugs & Compounds
for ACVR2B

Transcripts
for ACVR2B

Expression
for ACVR2B

Orthologs
for ACVR2B

Paralogs
for ACVR2B

SNPs/Variants
for ACVR2B

Disorders & Mutations
for ACVR2B

Medical News
for ACVR2B

Publications
for ACVR2B

Licensable Technologies
for ACVR2B

Services
for ACVR2B