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ACVR2A Gene

protein-coding GIFtS: 62

GC02P148319

activin A receptor, type IIA
(Previous names: activin A receptor, type II )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: ACVR2)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
ACTR-IIA ^³
ACTRII ^¹, ²
ACTRIIA ^³
ACVR2 ^², ³, ⁵
EC 2.7.11.30 ^³

Descriptions
Activin receptor type IIA ^³
activin A receptor, type II ^¹
activin A receptor, type IIA ^²

External Ids
HGNC: 173¹
Entrez Gene: 92²
UniProtKB: P27037³
Ensembl: ENSG00000121989⁷

Search outside databases for aliases for ACVR2A gene

Previous GC identifer: GC02P148437

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ACVR2A:

This gene encodes activin A type II receptor. Activins are dimeric growth and differentiation

factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally

related signaling proteins. Activins signal through a heteromeric complex of receptor serine

kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These

receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with

cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted

serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors

are required for binding ligands and for expression of type I receptors. Type I and II receptors

form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by

type II receptors. Type II receptors are considered to be constitutively active kinases. [provided

by RefSeq]

UniProtKB/Swiss-Prot: AVR2A_HUMAN, P27037

Function: On ligand binding, forms a receptor complex consisting of two type II and two type I

transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I

receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators.

Receptor for activin A, activin B and inhibin A

Gene Wiki entry for ACVR2A

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ACVR2A gene

Entrez Gene cytogenetic band: 2q22.3 Ensembl cytogenetic band: 2q22.3 HGNC cytogenetic band: 2q22.2-q23.3

ACVR2A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P148319: (about GC identifiers)

Start:	148,318,655 bp from pter
End:	148,404,863 bp from pter
Size:	86,209 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000002.10 NT_022135.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: AVR2A_HUMAN, P27037 (See protein sequence)

Recommended Name: Activin receptor type-2A precursor

Size: 513 amino acids; 57848 Da

Cofactor: Magnesium or manganese (By similarity)

Subunit: Interacts with AIP1. Part of a complex consisting of AIP1, ACVR2A, ACVR1B and SMAD3 (By

similarity)

Subcellular location: Membrane; Single-pass type I membrane protein

Secondary accessions: Q53TH4 Q6NWV2 Q92474

REFSEQ proteins: NP_001607.1

ENSEMBL proteins:

ENSP00000385568 ENSP00000241416 ENSP00000384338

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich Proteins for ACVR2A
	R&D Systems Recombinant & Natural Proteins for ACVR2A (Activin RIIA)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Activin Receptor Type IIA)
	Human Recombinant Proteins from Abnova (ACVR2A)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IDA	14738881
GO:0005886	plasma membrane	EXP	17356069
GO:0005887	integral to plasma membrane	TAS	1314589
GO:0034673	inhibin-betaglycan-ActRII complex	IDA	10746731

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Antibodies for ACVR2A:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for ACVR2A
	R&D Systems Antibodies for ACVR2A (Activin RIIA)
	Antibodies from Abcam (Activin Receptor Type IIA), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ACVR2A)
	Novus Biologicals Antibodies for ACVR2A

Assays for ACVR2A:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P27037

ProtoNet protein and cluster: P27037

2 Blocks protein families:

IPB000333 Activin type II receptor signature

IPB000472 Domain in TGF-beta receptor/activin receptor

UniProtKB/Swiss-Prot: AVR2A_HUMAN, P27037

Similarity: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB

receptor subfamily

Similarity: Contains 1 protein kinase domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ACVR2A)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ACVR2A)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001616

Applied Biosystems Silencer® siRNAs for ACVR2A

Sigma-Aldrich siRNA and siRNA Panels for ACVR2A

Sigma-Aldrich shRNA Panels and shRNA for ACVR2A

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ACVR2A
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001616
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001616
untagged cDNA clone in CMV expression vector: NM_001616

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001616

UniProtKB/Swiss-Prot: AVR2A_HUMAN, P27037

Function: On ligand binding, forms a receptor complex consisting of two type II and two type I

transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I

receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators.

Receptor for activin A, activin B and inhibin A

Catalytic activity: ATP + [receptor-protein] = ADP + [receptor-protein] phosphate

Enzyme Number (IUBMB): EC 2.7.11.30

13 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Acvr2a):

	craniofacial	digestive/alimentary	embryogenesis	endocrine/exocrine gland
growth/size	homeostasis/metabolism	lethality-prenatal/perinatal	nervous system	reproductive system
respiratory system	skeleton	vision/eye

5/11 Gene Ontology (GO) molecular function terms (links to tree view) (see all 11 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0000287	magnesium ion binding	IEA	--
GO:0005524	ATP binding	IEA	--
GO:0015026	coreceptor activity	IDA	10746731
GO:0016740	transferase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/6 Sigma-Aldrich "Your Favorite Gene" Pathways for ACVR2A (Your Favorite Gene powered by Ingenuity) (see all 6 )

Inositol Phosphate Metabolism
Nicotinate and Nicotinamide Metabolism
Wnt/&beta
TGF-&beta
Factors Promoting Cardiogenesis in Vertebrates

GeneDecks ACVR2A for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for ACVR2A

5/44 Interacting proteins for ACVR2A (P27037² ENSP00000241416³) via UniProtKB, MINT, and/or STRING (see all 44 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
BMP7	ENSP00000360340³	STRING (score=.999)
INHBA	ENSP00000242208³	STRING (score=.999)
BMP2	ENSP00000368104³	STRING (score=.998)
INHBE	ENSP00000266646³	STRING (score=.998)
INHBB	ENSP00000295228³	STRING (score=.997)

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5/16 Gene Ontology (GO) biological process terms (links to tree view) (see all 16 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001702	gastrulation with mouth forming second	IEA	--
GO:0006468	protein amino acid phosphorylation	IEA	--
GO:0007283	spermatogenesis	IEA	--
GO:0007368	determination of left/right symmetry	IEA	--
GO:0007498	mesoderm development	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ACVR2A
2 Novoseek chemical compound relationships for ACVR2A gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
threonine	64.05	2	10652306 (1), 12665502 (1)
ribonucleic acid	39.09	1	7962340 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ACVR2A)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ACVR2A)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001616

Sigma-Aldrich siRNA and siRNA Panels for ACVR2A

Sigma-Aldrich shRNA Panels and shRNA for ACVR2A

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001616

REFSEQ mRNAs for ACVR2A gene:

NM_001616.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001616

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001616
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001616
                                 untagged cDNA clone in CMV expression vector: NM_001616

Additional cDNA sequence:

AK301629.1 AK314124.1 BC067416.1 BC067417.1 BC067418.1 BC069707.1 D31770.1 M93415.1

X62381.1 X63128.1

10 DOTS entries:

DT.91752473 DT.91735091 DT.91866420 DT.116024 DT.121032318 DT.121032222 DT.429751 DT.435266

DT.97812347 DT.99958247

24/79 AceView cDNA sequences (see all 79 ):

BX281966 CB142176 BG616903 BE856769 AL047127 BM503220 BC069707 BX645435

X62381 BQ008322 AI554024 BC067418 BC067417 X63128 CB144602 BQ720564

AA331510 AI433335 BX492395 CF271903 AW044576 AI829731 NM_001616 AA952974

highest scoring ESTs for ACVR2A:

D31770 AA593728 AA918237 AA952974 AI335550 AI376182 AI433335 AI433467 AI433757 AI554024

Unigene Cluster for ACVR2A:

Activin A receptor, type IIA

Hs.470174 [show with all ESTs]

Unigene Representative Sequence: NM_001616

GeneLoc Exon Structure

3 Ensembl transcripts including schematic representations:

ENST00000402410 ENST00000241416 ENST00000404590

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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ACVR2A expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ACVR2A

¹ / ² / ³

7 probe-sets matching ACVR2A gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
53468_at²^{, 3}	U95-B	1	1.00	1.00	0.92	0.98	AI149508	0.80	0.80	0.80	1
35162_s_at²^{, 3}	U95-A	1	1.00	1.00	0.93	0.85	D31770	1.00	0.90	0.95	1
62358_at²^{, 3}	U95-C	1	0.94	1.00	0.78	1.18	AI433757	0.80	1.00	0.91	1
205327_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_001616	0.60	1.00	0.82	1
228416_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AI149508	0.80	0.80	0.80	1
205327_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
228416_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks ACVR2A for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.470174
Expression variation in blood from EXPOLDB for ACVR2A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for ACVR2A gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ACVR2A¹	--	activin A receptor, type IIA	95.26(n) 98.83(a)	476140 XM_852370.1 XP_857463.1
cow (Bos taurus)	ACVR2A¹	--	activin A receptor, type IIA	95.13(n) 98.64(a)	281598 NM_174227.2 NP_776652.1
rat (Rattus norvegicus)	Acvr2a¹	--	activin A receptor, type IIA	94.02(n) 99.42(a)	29263 NM_031571.1 NP_113759.1
mouse (Mus musculus)	Acvr2a^{1, 5}	2 (30.00 cM)⁵	activin receptor IIA^{1, 5}	94.48(n)¹ 99.22(a)¹	11480¹ NM_007396.3¹ NP_031422.2¹ AK041246⁵ AK141435⁵ (see all 17)
chicken (Gallus gallus)	ACVR2A¹	--	activin A receptor, type IIA	83.43(n) 92.59(a)	396324 NM_205367.1 NP_990698.1

About this table Species with no ortholog for ACVR2A

ENSEMBL Gene Tree for ACVR2A

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ACVR2A gene

TGFBR2² ACVR2B²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/281 NCBI SNPs in ACVR2A are shown (see all 281 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 110)

AB	SNP ID	Valid	Chr 2 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs1424954^1,2	A,C,F,H,O	148317264(+)	`ACAGAG/AACTGT`	1	--	ng5¹		5		EA NA EU WA	292
	rs17692648^1,2	C,F,H	148404201(+)	`TGAAAA/CTACAA`	1	--	ut3¹		12		NA EU EA WA	1054
--	rs12691769^1,2	A,C	148318008(+)	`TCGGTA/CTCAGA`	1	--	ng5¹		0	--	--	--	--
	rs13430086^1,2	F,H	148403531(+)	`AAAAAA/TTTTTT`	1	--	ut3¹		1		EU	120
--	rs12474653^1,2	A	148319013(+)	`TTTTTC/TCTTTT`	1	--	ng5¹ trp³		0	--	--	--	--
--	rs12053113^1,2	A	148318130(+)	`CCCTTC/TGGGTG`	1	--	ng5¹		0	--	--	--	--
	rs13224^1,2	C	148319154(+)	`ATCTAG/TCGAGA`	1	--	ut5¹		1		MN	184
--	rs12052736^1,2	A	148318147(+)	`CCAGAC/GAGGCC`	1	--	ng5¹		0	--	--	--	--
	rs34917571^1,2	C	148391423(+)	`ACCAGT/GGTTGA`	1	R/S	mis¹		4		EU EA WA	420
	rs1047081^1,2	H	148404773(+)	`ACCCCA/CCCTTG`	1	--	ut3¹		5		MN EU EA WA	602

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HapMap Linkage Disequilibrium images for ACVR2A (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 102581

10 Novoseek disease relationships for ACVR2A gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
microsatellite instability	41.80	1	12615714 (1)
colon cancer	34.67	12	15520171 (2), 14988818 (2), 16380996 (1), 17258738 (1) (see all 5)
preeclampsia	26.67	2	19126782 (1)
pheochromocytoma	9.28	1	10810314 (1)
pancreatic cancer	2.88	3	12615714 (2), 9714055 (1)
tumors	2.06	20	14988818 (3), 16380996 (3), 8636304 (2), 16337854 (2) (see all 8)
cancer	0.00	2	14988818 (1), 9714055 (1)
carcinoma	0.00	3	18077314 (1), 17121532 (1), 17478078 (1)
ovarian cancer	0.00	1	11306176 (1)
colorectal cancer	0.00	3	14988818 (2), 17609433 (1)

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Genetic Association Database: ACVR2A
Human Genome Epidemiology Navigator: ACVR2A (3 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/140 PubMed articles for ACVR2A gene (see all 140 ):

Molecular cloning and binding properties of the human type II activin receptor. (PubMed id 1314589)^{2, 3, 4} Donaldson C.J.... Vale W.W. (1992)
Influence of target gene mutations on survival, stage and histology in sporadic microsatellite unstable colon cancers. (PubMed id 16380996)^{1, 3, 6} Jung B....Carethers J.M. (2006)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)^{3, 4} Hillier L.W....Wilson R.K. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Assignment of ACVR2 and ACVR2B the human activin receptor type II and IIB genes to chromosome bands 2q22.2-->q23.3 and 3p22 and the human follistatin gene (FST) to chromosome 5q11.2 by FISH. (PubMed id 10702675)^{2, 3} Bondestam J....Aaltonen J. (1999)
Cloning of the human activin receptor cDNA reveals high evolutionary conservation. (PubMed id 1311955)^{3, 4} Matzuk M.M. and Bradley A. (1992)
Loss of activin receptor type 2 protein expression in microsatellite unstable colon cancers. (PubMed id 14988818)^{1, 3} Jung B....Carethers J.M. (2004)
Truncating mutations in the ACVR2 gene attenuates activin signaling in prostate cancer cells. (PubMed id 16337854)^{1, 3} Rossi M.R....Cowell J.K. (2005)
Activin type 2 receptor restoration in MSI-H colon cancer suppresses growth and enhances migration with activin. (PubMed id 17258738)^{1, 3} Jung B.H....Carethers J.M. (2007)
Repulsive guidance molecule RGMa alters utilization of bone morphogenetic protein (BMP) type II receptors by BMP2 and BMP4. (PubMed id 17472960)^{1, 3} Xia Y....Lin H.Y. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 92	HGNC: 173	AceView: ACVR2	Ensembl:ENSG00000121989	euGenes: HUgn92
ECgene: ACVR2A	H-InvDB: ACVR2A

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for ACVR2A	Genetics and Cytogenetics in Oncology and Haematology
CGP resequencing studies	http://www.sanger.ac.uk/perl/genetics/CGP/cgp_viewer?action=gene&ln=ACVR2

Licensable Technologies for ACVR2A
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for ACVR2A:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ACVR2A-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ACVR2A		Antibodies for ACVR2A
	Explore super-pooled esiRNAs		Proteins for ACVR2A
	Lentivirus-delivered shRNAs for ACVR2A		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (ACVR2A)
	Antibodies (ACVR2A)
	Chimera RNAi (ACVR2A)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	Recombinant Proteins (Activin Receptor Type IIA)
	Antibodies (Activin Receptor Type IIA)

Search OriGene for ACVR2A

Search Tocris compounds for ACVR2A

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Antibodies for ACVR2A

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ACVR2A Gene at Home site.
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ACVR2A Gene

protein-coding GIFtS: 62

Aliases &
Descriptions
for ACVR2A

Summaries
for ACVR2A

Genomic Location
for ACVR2A

Proteins
for ACVR2A

Protein Domains/
Families
for ACVR2A

Gene Function
for ACVR2A

Pathways & Interactions
for ACVR2A

Drugs & Compounds
for ACVR2A

Transcripts
for ACVR2A

Expression
for ACVR2A

Orthologs
for ACVR2A

Paralogs
for ACVR2A

SNPs/Variants
for ACVR2A

Disorders & Mutations
for ACVR2A

Medical News
for ACVR2A

Publications
for ACVR2A

Search for ACVR2A

Genome Databases showing ACVR2A

Other Databases showing ACVR2A

Specialized Databases showing ACVR2A

Licensable Technologies
for ACVR2A

Services
for ACVR2A

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ACVR2A Gene

protein-coding GIFtS: 62

Aliases & Descriptionsfor ACVR2A

Summariesfor ACVR2A

Genomic Locationfor ACVR2A

Proteinsfor ACVR2A

Protein Domains/Familiesfor ACVR2A

Gene Functionfor ACVR2A

Pathways & Interactionsfor ACVR2A

Drugs & Compoundsfor ACVR2A

Transcriptsfor ACVR2A

Expression for ACVR2A

Orthologsfor ACVR2A

Paralogsfor ACVR2A

SNPs/Variantsfor ACVR2A

Disorders & Mutationsfor ACVR2A

Medical Newsfor ACVR2A

Publicationsfor ACVR2A

Search for ACVR2A

Genome Databases showing ACVR2A

Other Databases showing ACVR2A

Specialized Databases showing ACVR2A

Licensable Technologiesfor ACVR2A

Servicesfor ACVR2A

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ACVR2A

Summaries
for ACVR2A

Genomic Location
for ACVR2A

Proteins
for ACVR2A

Protein Domains/
Families
for ACVR2A

Gene Function
for ACVR2A

Pathways & Interactions
for ACVR2A

Drugs & Compounds
for ACVR2A

Transcripts
for ACVR2A

Expression
for ACVR2A

Orthologs
for ACVR2A

Paralogs
for ACVR2A

SNPs/Variants
for ACVR2A

Disorders & Mutations
for ACVR2A

Medical News
for ACVR2A

Publications
for ACVR2A

Licensable Technologies
for ACVR2A

Services
for ACVR2A