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ACVR1C Gene

protein-coding GIFtS: 53

GC02M158097

activin A receptor, type IC
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
ACTR-IC ^³
ACVRLK7 ^¹, ²
ALK-7 ^³
ALK7 ^¹, ², ³, ⁵
EC 2.7.11.30 ^³

Descriptions
Activin receptor-like kinase 7 ^², ³
activin A receptor, type IC ^²

External Ids
HGNC: 18123¹
Entrez Gene: 130399²
UniProtKB: Q8NER5³
Ensembl: ENSG00000123612⁷

Search outside databases for aliases for ACVR1C gene

Previous GC identifers: GC02M158352 GC02M158592 GC02M158593 GC02M158214

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ACVR1C:

ACVR1C is a type I receptor for the TGFB (see MIM 190180) family of signaling molecules. Upon

ligand binding, type I receptors phosphorylate cytoplasmic SMAD transcription factors, which then

translocate to the nucleus and interact directly with DNA or in complex with other transcription

factors (Bondestam et al., 2001 [PubMed 12063393]).[supplied by OMIM]

UniProtKB/Swiss-Prot: ACV1C_HUMAN, Q8NER5

Function: Serine/threonine protein kinase which forms a receptor complex on ligand binding. The

receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type

II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and

activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and

NODAL. Plays a role in cell differentiation, growth arrest and apoptosis

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ACVR1C gene

Entrez Gene cytogenetic band: 2q24.1 Ensembl cytogenetic band: 2q24.1 HGNC cytogenetic band: 2q24.2

ACVR1C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M158097: (about GC identifiers)

Start:	158,097,150 bp from pter
End:	158,193,645 bp from pter
Size:	96,496 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000002.10 NT_005403.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ACV1C_HUMAN, Q8NER5 (See protein sequence)

Recommended Name: Activin receptor type-1C precursor

Size: 493 amino acids; 54871 Da

Cofactor: Magnesium or manganese

Subunit: Binds the type 2 receptor protein ACVR2A (By similarity)

Subcellular location: Membrane; Single-pass type I membrane protein

Secondary accessions: Q4ZFZ8 Q86UL1 Q86UL2 Q8TBG2

Alternative splicing: 4 isoforms: Q8NER5-1 Q8NER5-2 Q8NER5-3 Q8NER5-4

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (4 alternative transcripts):

NP_001104501.1 NP_001104502.1 NP_001104503.1 NP_660302.2

ENSEMBL proteins:

ENSP00000243349 ENSP00000335178 ENSP00000335139 ENSP00000387168

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Activin A Receptor Type IC)
	Human Recombinant Proteins from Abnova (ACVR1C)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	IEA	--
GO:0048179	activin receptor complex	IDA	15531507

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Antibodies for ACVR1C:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for ACVR1C
	R&D Systems Antibodies for ACVR1C (ALK-7)
	Antibodies from Abcam (Activin A Receptor Type IC), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ACVR1C)
	Novus Biologicals Antibodies for ACVR1C

Assays for ACVR1C:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q8NER5

ProtoNet protein and cluster: Q8NER5

1 Blocks protein family: IPB000472 Domain in TGF-beta receptor/activin receptor

UniProtKB/Swiss-Prot: ACV1C_HUMAN, Q8NER5

Similarity: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB

receptor subfamily

Similarity: Contains 1 GS domain

Similarity: Contains 1 protein kinase domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ACVR1C)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ACVR1C)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_145259

Applied Biosystems Silencer® siRNAs for ACVR1C

Sigma-Aldrich siRNA and siRNA Panels for ACVR1C

Sigma-Aldrich shRNA Panels and shRNA for ACVR1C

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ACVR1C
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_001111031
Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_001111031
untagged cDNA clones in CMV expression vector (see all 6): NM_001111031

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_145259

UniProtKB/Swiss-Prot: ACV1C_HUMAN, Q8NER5

Function: Serine/threonine protein kinase which forms a receptor complex on ligand binding. The

receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type

II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and

activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and

NODAL. Plays a role in cell differentiation, growth arrest and apoptosis

Catalytic activity: ATP + [receptor-protein] = ADP + [receptor-protein] phosphate

Enzyme Number (IUBMB): EC 2.7.11.30

2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Acvr1c):

life span-post-weaning/aging

normal

5/10 Gene Ontology (GO) molecular function terms (links to tree view) (see all 10 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0000287	magnesium ion binding	IEA	--
GO:0004674	protein serine/threonine kinase activity	IEA	--
GO:0004872	receptor activity	IEA	--
GO:0005024	transforming growth factor beta receptor activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

4 Sigma-Aldrich "Your Favorite Gene" Pathways for ACVR1C (Your Favorite Gene powered by Ingenuity)

TGF-&beta
PPAR&alpha
Wnt/&beta
Factors Promoting Cardiogenesis in Vertebrates

GeneDecks ACVR1C for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for ACVR1C

5/31 Interacting proteins for ACVR1C (ENSP00000243349³) via UniProtKB, MINT, and/or STRING (see all 31 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SMAD2	ENSP00000262160³	STRING (score=.985)
SMAD3	ENSP00000332973³	STRING (score=.985)
INHBE	ENSP00000266646³	STRING (score=.97)
GDF11	ENSP00000257868³	STRING (score=.943)
TGFB1	ENSP00000221930³	STRING (score=.941)

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3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006468	protein amino acid phosphorylation	IC	12063393
GO:0030154	cell differentiation	IDA	15531507
GO:0042981	regulation of apoptosis	IDA	15531507

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ACVR1C
1 Novoseek chemical compound relationship for ACVR1C gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
threonine	63.23	3	12063393 (1), 12606401 (1), 15196700 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ACVR1C)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ACVR1C)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_145259

Sigma-Aldrich siRNA and siRNA Panels for ACVR1C

Sigma-Aldrich shRNA Panels and shRNA for ACVR1C

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001111031 NM_001111032 NM_001111033 NM_145259

REFSEQ mRNAs for ACVR1C gene (4 alternative transcripts):

NM_001111031.1 NM_001111032.1 NM_001111033.1 NM_145259.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001111031 NM_001111032 NM_001111033 NM_145259

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_001111031
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_001111031
                                 untagged cDNA clones in CMV expression vector (see all 6): NM_001111031

Additional cDNA sequence:

AF525679.1 AF525680.1 AF525681.1 AY127050.1 BC022530.1 BC030101.2

7 DOTS entries:

DT.91745490 DT.100748869 DT.99928652 DT.100748870 DT.95179535 DT.75144520 DT.95303326

24/32 AceView cDNA sequences (see all 32 ):

BQ082584 CD637605 BP382222 CD637278 AF525679 CD637599 CD637609 NM_145259

CD637607 AF525681 BU167095 BC022530 CD637597 AY127050 BQ711640 CD637601

CD637603 CD637611 AF525680 CD637280 CD637613 CD637592 BU161536 CD637590

highest scoring ESTs for ACVR1C:

AF525680 AF525681 AY127050 BC022530 BG036887 BG716697 BI601014 BF966584 BQ082584 BU161536

Unigene Cluster for ACVR1C:

Activin A receptor, type IC

Hs.562901 [show with all ESTs]

Unigene Representative Sequence: NM_145259

GeneLoc Exon Structure

4 Ensembl transcripts including schematic representations:

ENST00000243349 ENST00000335450 ENST00000348328 ENST00000409680

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ACVR1C expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ACVR1C

¹ / ²

2 probe-sets matching ACVR1C gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1552519_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1563182_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.562901
UniProtKB/Swiss-Prot: ACV1C_HUMAN, Q8NER5
Tissue specificity: Present in pancreas, heart, colon, small intestine, ovary and the hippocampus,
medulla oblongata and putamen of the brain. Isoform 1, isoform 2, isoform 3 and isoform 4 are all
expressed in the placenta throughout pregnancy

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ACVR1C gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ACVR1C¹	--	activin A receptor, type IC	86.43(n) 90.08(a)	488361 XM_545483.2 XP_545483.2
chimpanzee (Pan troglodytes)	ACVR1C¹	--	activin A receptor, type IC	99.59(n) 99.39(a)	470564 XM_525945.2 XP_525945.2
cow (Bos taurus)	ACVR1C¹	--	activin A receptor, type IC	93.6(n) 97.65(a)	536380 XM_616508.3 XP_616508.3
rat (Rattus norvegicus)	Acvr1c¹	--	activin A receptor, type IC	86(n) 92.7(a)	245921 NM_139090.1 NP_620790.1
mouse (Mus musculus)	Acvr1c^{1, 5}	2⁵	activin A receptor, type IC^{1, 5}	87.01(n)¹ 95.91(a)¹	269275¹ NM_001033369.2¹ NP_001028541.1¹ AI643872⁵ AK049089⁵ (see all 10)

About this table Species with no ortholog for ACVR1C

ENSEMBL Gene Tree for ACVR1C

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ACVR1C gene

TGFBR1² ACVR1B²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/282 NCBI SNPs in ACVR1C are shown (see all 282 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 81)

AB	SNP ID	Valid	Chr 2 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs10167207^1,2	A,C,F,H	158094367(+)	`ATCTAA/CACAAA`	4	--	ut3¹		4	EU EA WA	418
	rs6734630^1,2	A,C,F,H	158093044(+)	`CCTAAA/GGCACT`	4	--	ut3¹		7	EU EA WA NA	558
	rs4556933^1,2	A,C,F,H	158152135(+)	`CAGGTG/AAAGTT`	4	F/F	syn¹ ut5¹		9	EU EA WA NA	848
	rs7594480^1,2	C,F,H	158098714(+)	`AGATAT/CAGTCT`	4	V/I	mis¹ ese³		8	EU EA WA	838
	rs4664229^1,2	C,F,H	158095184(+)	`AAAGAT/CAACCC`	4	--	ut3¹		7	EU EA WA NA	558
	rs12993800^1,2	C,F,H	158097025(+)	`TGGGAC/TAGTAA`	4	--	ut3¹		8	EU EA WA	836
	rs35500979^1,2	C	158107501(+)	`GTCGAT/CAGTGT`	4	V/I	mis¹		4	EU EA WA	420
	rs6751595^1,2	H	158097764(+)	`TATGAG/TAAAAA`	4	--	ut3¹		4	EU EA WA	418
--	rs17180418^1,2	F	158162284(+)	`CTCCCG/ACGGGG`	2	--	ut5¹ int¹		3	NA	142
	rs34742924^1,2	C	158115049(+)	`TTCCCC/GACACC`	3	G/R	mis¹		4	EU EA WA	420

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HapMap Linkage Disequilibrium images for ACVR1C (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 608981

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/20 PubMed articles for ACVR1C gene (see all 20 ):

Identification of novel isoforms of activin receptor-like kinase 7 (ALK7) generated by alternative splicing and expression of ALK7 and its ligand, Nodal, in human placenta. (PubMed id 12606401)^{1, 3, 4} Roberts H.J.... Peng C. (2003)
cDNA cloning, expression studies and chromosome mapping of human type I serine/threonine kinase receptor ALK7 (ACVR1C). (PubMed id 12063393)^{1, 3, 4} Bondestam J.... Ritvos O. (2001)
Nodal induces apoptosis and inhibits proliferation in human epithelial ovarian cancer cells via activin receptor-like kinase 7. (PubMed id 15531507)^{1, 3, 4} Xu G.... Peng C. (2004)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)^{3, 4} Hillier L.W....Wilson R.K. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
ALK7 expression is specific for adipose tissue, reduced in obesity and correlates to factors implicated in metabolic disease. (PubMed id 19275893)^{1, 3} Carlsson L.M....SjAPholm K. (2009)
Cyclin G2 is degraded through the ubiquitin-proteasome pathway and mediates the antiproliferative effect of activin receptor-like kinase 7. (PubMed id 18784254)^{1, 3} Xu G....Peng C. (2008)
Nodal and ALK7 inhibit proliferation and induce apoptosis in human trophoblast cells. (PubMed id 15150278)^{1, 3} Munir S....Peng C. (2004)
Activin receptor-like kinase 7 induces apoptosis through up-regulation of Bax and down-regulation of Xiap in normal and malignant ovarian epithelial cell lines. (PubMed id 16603637)^{1, 3} Xu G....Peng C. (2006)
Insulin gene is a target in activin receptor-like kinase 7 signaling pathway in pancreatic beta-cells. (PubMed id 18951876)^{1, 3} Watanabe R....Yamada Y. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 130399	HGNC: 18123	AceView: ACVR1C	Ensembl:ENSG00000123612	euGenes: HUgn130399
ECgene: ACVR1C	H-InvDB: ACVR1C

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for ACVR1C	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for ACVR1C
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ACVR1C:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ACVR1C-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ACVR1C		Antibodies for ACVR1C
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ACVR1C		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (ACVR1C)
	Antibodies (ACVR1C)
	Chimera RNAi (ACVR1C)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	Recombinant Proteins (Activin A Receptor Type IC)
	Antibodies (Activin A Receptor Type IC)

Search OriGene for ACVR1C

Search Tocris compounds for ACVR1C

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

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ACVR1C Gene

protein-coding GIFtS: 53

Aliases &
Descriptions
for ACVR1C

Summaries
for ACVR1C

Genomic Location
for ACVR1C

Proteins
for ACVR1C

Protein Domains/
Families
for ACVR1C

Gene Function
for ACVR1C

Pathways & Interactions
for ACVR1C

Drugs & Compounds
for ACVR1C

Transcripts
for ACVR1C

Expression
for ACVR1C

Orthologs
for ACVR1C

Paralogs
for ACVR1C

SNPs/Variants
for ACVR1C

Disorders & Mutations
for ACVR1C

Medical News
for ACVR1C

Publications
for ACVR1C

Search for ACVR1C

Genome Databases showing ACVR1C

Other Databases showing ACVR1C

Specialized Databases showing ACVR1C

Licensable Technologies
for ACVR1C

Services
for ACVR1C

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ACVR1C Gene

protein-coding GIFtS: 53

Aliases & Descriptionsfor ACVR1C

Summariesfor ACVR1C

Genomic Locationfor ACVR1C

Proteinsfor ACVR1C

Protein Domains/Familiesfor ACVR1C

Gene Functionfor ACVR1C

Pathways & Interactionsfor ACVR1C

Drugs & Compoundsfor ACVR1C

Transcriptsfor ACVR1C

Expression for ACVR1C

Orthologsfor ACVR1C

Paralogsfor ACVR1C

SNPs/Variantsfor ACVR1C

Disorders & Mutationsfor ACVR1C

Medical Newsfor ACVR1C

Publicationsfor ACVR1C

Search for ACVR1C

Genome Databases showing ACVR1C

Other Databases showing ACVR1C

Specialized Databases showing ACVR1C

Licensable Technologiesfor ACVR1C

Servicesfor ACVR1C

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ACVR1C

Summaries
for ACVR1C

Genomic Location
for ACVR1C

Proteins
for ACVR1C

Protein Domains/
Families
for ACVR1C

Gene Function
for ACVR1C

Pathways & Interactions
for ACVR1C

Drugs & Compounds
for ACVR1C

Transcripts
for ACVR1C

Expression
for ACVR1C

Orthologs
for ACVR1C

Paralogs
for ACVR1C

SNPs/Variants
for ACVR1C

Disorders & Mutations
for ACVR1C

Medical News
for ACVR1C

Publications
for ACVR1C

Licensable Technologies
for ACVR1C

Services
for ACVR1C