ACVR1C Gene
protein-coding GIFtS : 66
GCID: GC02 M158352
activin A receptor, type IC
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Aliasesfor ACVR1C gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Activin A Receptor, Type IC 1 2 ACTR-IC2 3 ALK71 2 3 5 ALK-72 3 ACVRLK71 2 EC 2.7.11.303 8 Activin Receptor Type IC2 3 Activin Receptor Type-1C2 Activin Receptor-Like Kinase 72 3 EC 2.7.118
Export aliases for ACVR1C gene to outside databases Previous GC identifers: GC02M158592 GC02M158593 GC02M158214 GC02M158097 GC02M150268
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Summariesfor ACVR1C gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for ACVR1C : ACVR1C is a type I receptor for the TGFB (see MIM 190180) family of signaling molecules. Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors (Bondestam et al., 2001 (PubMed 12063393)).(supplied by OMIM, Mar 2008) UniProtKB/Swiss-Prot: ACV1C_HUMAN, Q8NER5 Function : Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complexconsisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis summary
for ACVR1C : Activin receptors transduce signals carried by the TGF-? family of ligands. Such ligands include activin andbone morphogenetic proteins (BMPs). Members of this family are involved in a range of processes, includingembryogenesis and tissue homeostasis. Bone morphogenetic proteins (BMPs) are a group of growth factorsbelonging to the transforming growth factor-? (TGF-?) superfamily (excluding BMP1). Primarily characterizedby their effects on bone and cartilage formation, research has further elucidated a role for BMPs in cellgrowth and development.There are currently 20 known BMP isoforms, which form dimers in order to bind atetrameric receptor complex composed of type I and type II BMP receptor subunits. ALK2, ALK3 and ALK6function as BMP type I receptors, the latter of which are structurally similar. Three BMP type II receptorshave also been identified: BMPR2, and type II and IIB activin receptors (ACVR2A and ACVR2B). ALK2, ACVR2Aand ACVR2B also function as receptors for activins.Signal transduction is continued through Smad proteins.Receptor-regulated Smads (R-Smads) are phosphorylated by activation of type I receptors and form heteromericcomplexes with Co-Smads. These complexes regulate the transcription of target genes in the nucleus. Gene Wiki entry for ACVR1C
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Genomic Viewsfor ACVR1C gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000002.11 NC_018913.1 NT_005403.17 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the ACVR1C gene promoter: USF1 Pbx1a Bach2 XBP-1 Cdc5 AREB6 S8 POU2F1 USF-1 POU2F1a Other transcription factors Search SABiosciences Chromatin IP Primers for ACVR1C Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat ACVR1C
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 2q24.1 Ensembl cytogenetic band: 2q24.1 HGNC cytogenetic band: 2q24.2 ACVR1C Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 2 GeneLoc Exon Structure
GeneLoc location for GC02M158352: view genomic region
(about GC identifiers )
Start:
158,383,279 bp from pter
End:
158,485,517 bp from pter
Size:
102,239 bases
Orientation:
minus strand
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Proteinsfor ACVR1C gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: ACV1C_HUMAN, Q8NER5 (See
protein sequence )Recommended Name: Activin receptor type-1C precursor Size : 493 amino acids; 54871 Da
Cofactor : Magnesium or manganese
Subunit : Binds the type 2 receptor protein ACVR2A (By similarity)
Subcellular location : Membrane; Single-pass type I membrane protein
Secondary accessions : Q4ZFZ8 Q86UL1 Q86UL2 Q8TBG2Alternative splicing : 4 isoforms : Q8NER5-1 Q8NER5-2 Q8NER5-3 Q8NER5-4 Explore the universe of human proteins at neXtProt for ACVR1C: NX_Q8NER5 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q8NER5 4/12 DME Specific Peptides for ACVR1C (Q8NER5 ) (see all 12 )ACVR1C Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins (4 alternative transcripts):
NP_001104501.1 NP_001104502.1 NP_001104503.1 NP_660302.2 ENSEMBL proteins: ENSP00000243349 ENSP00000387168 ENSP00000335139 ENSP00000335178 Reactome Protein details: Q8NER5 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
ACVR1C for ontologies About GeneDecksing ACVR1C Antibody Products: Assay Products for ACVR1C:
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Protein
Domains / Familiesfor ACVR1C gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
ACVR1C for domains About GeneDecksing 5/6 InterPro domains/families (see all 6 ):
Graphical View of Domain Structure for InterPro Entry Q8NER5 ProtoNet protein and cluster: Q8NER5
1 Blocks protein family : IPB000472 Domain in TGF-beta receptor/activin receptor UniProtKB/Swiss-Prot: ACV1C_HUMAN, Q8NER5 Similarity : Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamilySimilarity : Contains 1 GS domainSimilarity : Contains 1 protein kinase domain
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Functionfor ACVR1C gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: ACV1C_HUMAN, Q8NER5 Function : Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complexconsisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis Catalytic activity : ATP + [receptor-protein] = ADP + [receptor-protein] phosphateEnzyme Numbers (IUBMB): EC 2.7.11.30 1 2 EC 2.7.11 2
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ACVR1C (see all 7 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ACVR1C (see all 6 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 4 ): ACVR1C (NM_145259 ) Sino Biological Human cDNA Clone for ACVR1C DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ACVR1C Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ACVR1C
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACVR1C
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view) : About this table
ACVR1C for ontologies About GeneDecksing 3 GenomeRNAi human phenotypes for ACVR1C :Animal Models: 2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Acvr1c) :
ACVR1C for phenotypes About GeneDecksing
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Pathways & Interactionsfor ACVR1C gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways  - 5/6 super-pathways (see all 6 ) About this table See pathways by source Super-pathway contained gene-specific pathways 1 Signaling by NODAL 2 Human Embryonic Stem Cell Pluripotency 3 MAPK signaling pathway 4 TGF-beta signaling pathway 5 Axon guidance
Pathway sources See GeneCards unified pathways Show all pathways 1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for ACVR1C 1 BioSystems Pathway for ACVR1C 5
Reactome Pathways for ACVR1C 1
Kegg Pathway (Kegg details for ACVR1C) :
ACVR1C for pathways About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ACVR1C STRING Interaction
Network Preview (showing 5 interactants - click image to see 7)5/8 Interacting proteins for ACVR1C (Q8NER5 3 ENSP00000243349 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 8 )About this table Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13 ): About this table
ACVR1C for ontologies About GeneDecksing
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Drugs & Compoundsfor ACVR1C gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section
ACVR1C for compounds About GeneDecksing Compounds for ACVR1C available from Tocris Bioscience About this table Compound Action
CAS
# A 83-01 Selective inhibitor of TGF-betaRI, ALK4 and ALK7 [909910-43-6] SB 431542 Potent, selective inhibitor of TGF-betaRI, ALK4 and ALK7 [301836-41-9]
4 HMDB Compounds for ACVR1C About this table 2 Novoseek chemical compound relationships for ACVR1C gene About this table
Search CenterWatch for drugs/clinical trials and news about ACVR1C / ACV1C
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Transcriptsfor ACVR1C gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for ACVR1C gene (4 alternative transcripts): NM_001111031.1 NM_001111032.1 NM_001111033.1 NM_145259.2 Unigene Cluster for ACVR1C:
Activin A receptor, type IC Hs.562901 [show with all ESTs ] Unigene Representative Sequence: NM_145259 4 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000243349 (uc010foe.3 uc002tzk.4 uc002tzl.4 uc010fof.3 )ENST00000409680 ENST00000348328 ENST00000335450 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ACVR1C (see all 7 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ACVR1C (see all 6 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 4 ): ACVR1C (NM_145259 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ACVR1C Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ACVR1C
Additional cDNA sequence: AF525679.1 AF525680.1 AF525681.1 AY127050.1 BC022530.1 BC030101.2
7 DOTS entries : DT.91745490 DT.100748869
DT.99928652 DT.100748870 DT.95179535 DT.75144520 DT.95303326 24/32 AceView cDNA sequences (see all 32 ):
BQ082584 CD637599 CD637613 CD637605 CD637603 AY127050 CD637609 CD637592 AF525681 BC022530 AF525679 CD637607 CD637278 BQ711640 NM_145259 CD637601 CD637611 AF525680 CD637280 BP382222 CD637597 BU167095 BE787024 BF966584 GeneLoc Exon Structure
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Expression for ACVR1C gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section ACVR1C expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: --
About this image ACVR1C expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table 2 LifeMap In Vivo Development Anatomical Compartments/Cells Tissue Anatomical Compartment
Cell Category (developmental path) Testis Seminiferous Tubules Sertoli cells Testis Bone Maxillary Process Bone Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See ACVR1C Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for ACVR1C SOURCE GeneReport for Unigene cluster: Hs.562901 UniProtKB/Swiss-Prot: ACV1C_HUMAN, Q8NER5 Tissue specificity : Present in pancreas, heart, colon, small intestine, ovary and the hippocampus, medulla oblongataand putamen of the brain. Isoform 1, isoform 2, isoform 3 and isoform 4 are all expressed in the placenta throughout pregnancy SABiosciences Expression via Pathway-Focused PCR Array including ACVR1C : Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for ACVR1CBrowse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat ACVR1C QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat ACVR1C QIAGEN QuantiFast Probe-based Assays in human , mouse , rat ACVR1C In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACVR1C
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Orthologsfor ACVR1C gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for ACVR1C gene from 5/19 species (see all 19 ) About this table
ENSEMBL Gene Tree for ACVR1C (if available)TreeFam Gene Tree for ACVR1C (if available)
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Paralogsfor ACVR1C gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for ACVR1C gene TGFBR2 2 AMHR2 2 ACVR2A 2 ACVR2B 2 ACVR1B 2 TGFBR1 2 BMPR1A 2 ACVR1 2 BMPR2 2 ACVRL1 2 BMPR1B 2 9 SIMAP similar genes for ACVR1C using alignment to 2 protein entries: ACV1C_HUMAN (see all proteins ):ACVR1B ACVRL1 TGFBR1 ACVR1 BMPR1A BMPR1B ACVR2B ACVR2A TGFBR2
ACVR1C for paralogs About GeneDecksing 1 Pseudogenes.org Pseudogene for ACVR1C PGOHUM00000261257
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Genomic Variantsfor ACVR1C gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 2 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for ACVR1C (158383279 - 158485517 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 5 variations for ACVR1C 5 Indels : 40379 45882 42304 26472 98026 Human Gene Mutation Database (HGMD) : ACVR1C SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing ACVR1C
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Disorders
/ Diseasesfor ACVR1C gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
ACVR1C for disorders About GeneDecksing
OMIM gene information: 608981
OMIM disorders : --7 diseases for ACVR1C : About MalaCards fibrodysplasia ossificans progressiva epithelial ovarian cancer ovarian cancer pharyngitis obesity pancreatitis neuronitis 1 disease from the University of Copenhagen DISEASES database for ACVR1C :Myositis ossificans Human Genome Epidemiology (HuGE) Navigator: ACVR1C (1 document)Export disorders for ACVR1C gene to outside databases
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Publicationsfor ACVR1C gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for ACVR1C gene, integrated from 9 sources (see all 23 ): (articles sorted by number of sources associating them with ACVR1C) Utopia : connect your pdf to the dynamic world of online information
Identification of novel isoforms of activin receptor-like kinase 7 (ALK7) generated by alternative splicing and expression of ALK7 and its ligand, Nodal, in human placenta. (PubMed id 12606401) 1 , 2 , 9 Roberts H.J.... Peng C. (2003) cDNA cloning, expression studies and chromosome mapping of human type I serine/threonine kinase receptor ALK7 (ACVR1C). (PubMed id 12063393) 1 , 2 , 9 Bondestam J.... Ritvos O. (2001) Nodal induces apoptosis and inhibits proliferation in human epithelial ovarian cancer cells via activin receptor-like kinase 7. (PubMed id 15531507) 1 , 2 , 9 Xu G.... Peng C. (2004) Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621) 1 , 2 Hillier L.W....Wilson R.K. (2005) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) ALK7 expression is specific for adipose tissue, reduced in obesity and correlates to factors implicated in metabolic disease. (PubMed id 19275893) 1 , 9 Carlsson L.M....SjAPholm K. (2009) Cyclin G2 is degraded through the ubiquitin-proteasome pathway and mediates the antiproliferative effect of activin receptor-like kinase 7. (PubMed id 18784254) 1 , 9 Xu G....Peng C. (2008) Nodal and ALK7 inhibit proliferation and induce apoptosis in human trophoblast cells. (PubMed id 15150278) 1 , 9 Munir S....Peng C. (2004) Activin receptor-like kinase 7 induces apoptosis through up-regulation of Bax and down-regulation of Xiap in normal and malignant ovarian epithelial cell lines. (PubMed id 16603637) 1 , 9 Xu G....Peng C. (2006) Insulin gene is a target in activin receptor-like kinase 7 signaling pathway in pancreatic beta-cells. (PubMed id 18951876) 1 , 9 Watanabe R....Yamada Y. (2008)
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External Searches for ACVR1C gene
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Genome Databases showing ACVR1C gene
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Other Databases showing ACVR1C gene
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Specialized Databases showing ACVR1C gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for ACVR1C gene: Search GeneIP for patents involving ACVR1C GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor ACVR1C gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for ACVR1C OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for ACVR1C OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for ACVR1C OriGene Protein Over-expression Lysate for ACVR1C Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for ACVR1C OriGene 3'-UTR Clone for ACVR1C OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ACVR1C OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ACVR1C Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for ACVR1C OriGene Custom Protein Services for ACVR1C OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ACVR1C QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing ACVR1C QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat ACVR1C QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat ACVR1C QIAGEN QuantiFast Probe-based Assays in human , mouse , rat ACVR1C QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat ACVR1C
ACVR1C Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACVR1C
ThermoFisher Antibodies for ACVR1C
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ACVR1C
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