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ACVR1B Gene

protein-coding GIFtS: 60

GC12P050631

activin A receptor, type IB
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: ACVRLK4)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
ACTR-IB ^³
ACTRIB ^²
ACVRLK4 ^², ³, ⁵
ALK-4 ^³
ALK4 ^¹, ², ³, ⁵
ActRIB ^¹
EC 2.7.11.30 ^³
SKR2 ^¹, ², ³

Descriptions
Activin receptor-like kinase 4 ^², ³
Serine/threonine-protein kinase receptor R2 ^³
activin A receptor, type IB ^²
activin A receptor, type II-like kinase 4 ^²
activin A type IB receptor ^²
serine(threonine) protein kinase receptor R2 ^²

External Ids
HGNC: 172¹
Entrez Gene: 91²
UniProtKB: P36896³
Ensembl: ENSG00000135503⁷

Search outside databases for aliases for ACVR1B gene

Previous GC identifers: GC12M052557 GC12P052375 GC12P052062 GC12P050494

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ACVR1B:

Activins are dimeric growth and differentiation factors which belong to the transforming growth

factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal

through a heteromeric complex of receptor serine kinases which include at least two type I (I and

IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins,

composed of a ligand-binding extracellular domain with a cysteine-rich region, a transmembrane

domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are

essential for signaling, and type II receptors are required for binding ligands and for expression

of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting

in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type IB

receptor, composed of 11 exons. Alternative splicing and alternative polyadenylation result in 3

fully described transcript variants. The mRNA expression of variants 1, 2, and 3 is confirmed, and

a potential fourth variant contains an alternative exon 8 and lacks exons 9 through 11, but its

mRNA expression has not been confirmed. [provided by RefSeq]

UniProtKB/Swiss-Prot: ACV1B_HUMAN, P36896

Function: On ligand binding, forms a receptor complex consisting of two type II and two type I

transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I

receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators.

Phosphorylates TTRAP

Gene Wiki entry for ACVR1B

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ACVR1B gene

Entrez Gene cytogenetic band: 12q13 Ensembl cytogenetic band: 12q13.13 HGNC cytogenetic band: 12q13

ACVR1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P050631: (about GC identifiers)

Start:	50,631,753 bp from pter
End:	50,677,127 bp from pter
Size:	45,375 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000012.10 NT_029419.11

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ACV1B_HUMAN, P36896 (See protein sequence)

Recommended Name: Activin receptor type-1B precursor

Size: 505 amino acids; 56807 Da

Cofactor: Magnesium or manganese (By similarity)

Subunit: Interacts with AIP1. Part of a complex consisting of AIP1, ACVR2A, ACVR1B and SMAD3.

Interacts with TTRAP (By similarity)

Subcellular location: Membrane; Single-pass type I membrane protein

Secondary accessions: Q15479 Q15480 Q15481 Q15482

Alternative splicing: 3 isoforms: P36896-1 P36896-2 P36896-3

Post-translational modifications:

Autophosphorylated¹

REFSEQ proteins (3 alternative transcripts):

NP_004293.1 NP_064732.2 NP_064733.2

ENSEMBL proteins:

ENSP00000257963

Human Recombinant Proteins

	Invitrogen human recombinant proteins for ACVR1B
	Millipore Purified and/or Recombinant ACVR1B Protein
	Sigma-Aldrich Proteins for ACVR1B
	R&D Systems Recombinant & Natural Proteins for ACVR1B (Activin RIB/ALK-4)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Activin A Receptor Type IB)
	Human Recombinant Proteins from Abnova (ACVR1B)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005887	integral to plasma membrane	IDA	9032295
GO:0009986	cell surface	IDA	12665502
GO:0016020	membrane	IEA	--

About this table

Antibodies for ACVR1B:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for ACVR1B
	R&D Systems Antibodies for ACVR1B (Activin RIB/ALK-4)
	Antibodies from Abcam (Activin A Receptor Type IB), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ACVR1B)
	Novus Biologicals Antibodies for ACVR1B

Assays for ACVR1B:

	Invitrogen Assays for ACVR1B
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P36896

ProtoNet protein and cluster: P36896

1 Blocks protein family: IPB000472 Domain in TGF-beta receptor/activin receptor

UniProtKB/Swiss-Prot: ACV1B_HUMAN, P36896

Similarity: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB

receptor subfamily

Similarity: Contains 1 GS domain

Similarity: Contains 1 protein kinase domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ACVR1B)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ACVR1B)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_004302

Applied Biosystems Silencer® siRNAs for ACVR1B

Sigma-Aldrich siRNA and siRNA Panels for ACVR1B

Sigma-Aldrich shRNA Panels and shRNA for ACVR1B

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ACVR1B
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_004302
Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_004302
untagged cDNA clones in CMV expression vector (see all 4): NM_004302

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_004302

UniProtKB/Swiss-Prot: ACV1B_HUMAN, P36896

Function: On ligand binding, forms a receptor complex consisting of two type II and two type I

transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I

receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators.

Phosphorylates TTRAP

Catalytic activity: ATP + [receptor-protein] = ADP + [receptor-protein] phosphate

Enzyme Number (IUBMB): EC 2.7.11.30

Genatlas biochemistry entry for ACVR1B:

activin A receptor,type IB

6 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Acvr1b):

cellular	embryogenesis	lethality-prenatal/perinatal	life span-post-weaning/aging	nervous system
respiratory system

5/13 Gene Ontology (GO) molecular function terms (links to tree view) (see all 13 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0000287	magnesium ion binding	IEA	--
GO:0004674	protein serine/threonine kinase activity	IDA	18039968
GO:0004872	receptor activity	IEA	--
GO:0005524	ATP binding	IDA	12065756

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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4 Sigma-Aldrich "Your Favorite Gene" Pathways for ACVR1B (Your Favorite Gene powered by Ingenuity)

PPAR&alpha
Factors Promoting Cardiogenesis in Vertebrates
TGF-&beta
Wnt/&beta

GeneDecks ACVR1B for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for ACVR1B

5/40 Interacting proteins for ACVR1B (ENSP00000257963³) via UniProtKB, MINT, and/or STRING (see all 40 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
INHBE	ENSP00000266646³	STRING (score=.997)
INHBA	ENSP00000242208³	STRING (score=.995)
SMAD2	ENSP00000262160³	STRING (score=.993)
SMAD3	ENSP00000332973³	STRING (score=.993)
INHBB	ENSP00000295228³	STRING (score=.989)

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5/13 Gene Ontology (GO) biological process terms (links to tree view) (see all 13 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000082	G1/S transition of mitotic cell cycle	IDA	11117535
GO:0001701	in utero embryonic development	IEA	--
GO:0001942	hair follicle development	IEA	--
GO:0006917	induction of apoptosis	IMP	9884026
GO:0007165	signal transduction	IDA	8622651 12665502

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ACVR1B
1 Novoseek chemical compound relationship for ACVR1B gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
threonine	68.00	4	12853652 (1), 12682303 (1), 11909953 (1), 12665502 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ACVR1B)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ACVR1B)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_004302

Sigma-Aldrich siRNA and siRNA Panels for ACVR1B

Sigma-Aldrich shRNA Panels and shRNA for ACVR1B

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_004302 NM_020327 NM_020328

REFSEQ mRNAs for ACVR1B gene (3 alternative transcripts):

NM_004302.3 NM_020327.2 NM_020328.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_004302 NM_020327 NM_020328

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_004302
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_004302
                                 untagged cDNA clones in CMV expression vector (see all 4): NM_004302

Additional cDNA sequence:

AK299120.1 AK299496.1 AL117643.1 BC000254.1 BC034008.1 BC040531.1 BT007072.1 L10125.1

L10126.1 U14722.1 Z22536.1

8 DOTS entries:

DT.86845897 DT.100771615 DT.101976747 DT.87046577 DT.40220232 DT.40299238 DT.75155814 DT.95330621

24/164 AceView cDNA sequences (see all 164 ):

AA436109 AI079778 BE222288 AW026270 F09752 AU131576 BU949145 AL709104

BX099760 AA902887 BC000254 F12114 AW614156 U14722 BM975377 BU943859

BU949388 NM_004302 N48845 BT007072 BM810200 CB529620 BF111083 AW772334

highest scoring ESTs for ACVR1B:

AA723548 Z22536 AA436109 AA480376 AA568137 AA622091 AA700528 AA771991 AA781329 AA838698

Unigene Cluster for ACVR1B:

Activin A receptor, type IB

Hs.438918 [show with all ESTs]

Unigene Representative Sequence: BC040531

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000257963

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ACVR1B expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ACVR1B

¹ / ² / ³

18 probe-sets matching ACVR1B gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
34056_g_at²^{, 3}	U95-A	1	1.00	1.00	0.87	0.66	L10126	0.80	1.00	0.91	1
34415_at²^{, 3}	U95-A	1	1.00	1.00	0.67	1.03	Z22536	1.00	0.90	0.95	1
34055_at²^{, 3}	U95-A	1	1.00	1.00	0.75	0.55	L10126	0.80	1.00	0.91	1
921_s_at²^{, 3}	U95-A	1	1.00	1.00	0.73	0.68	HG921-HT3995	0.20	1.00	0.72	1
36451_at²^{, 3}	U95-A	1	1.00	1.00	0.78	1.58	AI743299	0.60	0.83	0.73	1
75350_at²^{, 3}	U95-D	1	0.94	1.00	0.24	1.55	AA723548	1.00	1.00	1.00	1
208223_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_020327	0.60	1.00	0.82	1
205209_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BC000254	0.80	0.88	0.84	1
208218_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_020328	0.60	1.00	0.82	1
208222_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_020327	0.60	1.00	0.82	1
208219_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_020328	0.60	1.00	0.82	1
213198_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AL117643	0.60	1.00	0.82	1
208223_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
205209_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
208218_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
208222_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
208219_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
213198_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks ACVR1B for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.438918
Expression variation in blood from EXPOLDB for ACVR1B
UniProtKB/Swiss-Prot: ACV1B_HUMAN, P36896
Tissue specificity: Expressed in many tissues, most strongly in kidney, pancreas, brain, lung, and
liver

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ACVR1B gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ACVR1B¹	--	activin A receptor, type IB	93.63(n) 98.95(a)	486537 XM_543663.2 XP_543663.2
chimpanzee (Pan troglodytes)	ACVR1B¹	--	activin A receptor, type IB	99.54(n) 100(a)	451911 XM_001145219.1 XP_001145219.1
cow (Bos taurus)	ACVR1B¹	--	activin A receptor, type IB	91.93(n) 99.37(a)	539315 XM_586402.3 XP_586402.3
rat (Rattus norvegicus)	Acvr1b¹	--	activin A receptor, type IB	91.22(n) 98.81(a)	29381 NM_199230.1 NP_954700.1
mouse (Mus musculus)	Acvr1b^{1, 5}	15 (60.40 cM)⁵	activin A receptor, type 1B^{1, 5}	90.83(n)¹ 98.22(a)¹	11479¹ NM_007395.3¹ NP_031421.1¹ AI851648⁵ AK078525⁵ (see all 12)

About this table Species with no ortholog for ACVR1B

ENSEMBL Gene Tree for ACVR1B

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ACVR1B gene

ACVR1C² TGFBR1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/180 NCBI SNPs in ACVR1B are shown (see all 180 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 66)

AB	SNP ID	Valid	Chr 12 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs2252526^1,2	A,C,F,H,O	50667497(+)	`CAGCTG/TCTTAT`	3	--	int¹ ng3¹		9	EA EU WA NA	2252
	rs2252518^1,2	A,C,F,H	50667293(+)	`GTGCGC/AATAGC`	3	--	ut3¹ int¹		5	EA EU WA	1896
	rs2854464^1,2	A,C,F,H	50675158(+)	`CAGCCA/GTGGGA`	1	--	ut3¹ ese³		9	EA EU WA NA	2094
	rs3058^1,2	C,F,O	50672209(+)	`TACAGT/CCTCTT`	2	--	int¹ ut3¹		7	NA EU EA WA	562
	rs34050429^1,2	C,F	50667165(+)	`GGTGCG/ATTTAT`	3	H/R	mis¹ int¹		4	EU EA WA	420
	rs2641529^1,2	H	50674269(-)	`TCCTGG/TCCACA`	1	--	ut3¹ ese³		4	EU EA WA	416
	rs34570151^1,2	F	50676260(+)	`ACTGCA/GTTCAT`	1	--	ut3¹		2	NA	182
	rs34488074^1,2	C	50656482(+)	`TTGTTT/CTCCTT`	3	L/F	mis¹		4	EU EA WA	420
	rs2714^1,2	F	50675551(+)	`TTGGTC/AAGCAT`	1	--	ut3¹ ese³		1	MN	184
	rs10876226^1,2	H	50672134(+)	`CAGAGG/AAGCCC`	2	--	int¹ ut3¹		4	EU EA WA	406

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HapMap Linkage Disequilibrium images for ACVR1B (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 601300

3 Novoseek disease relationships for ACVR1B gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
pancreatic cancer	12.72	2	11248065 (1), 9714055 (1)
cancer	0.00	3	15753386 (1), 9714055 (1), 11511564 (1)
tumors	0.00	1	8636304 (1)

About this table

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/86 PubMed articles for ACVR1B gene (see all 86 ):

Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity. (PubMed id 8397373)^{1, 2, 3, 4} ten Dijke P.... Miyazono K. (1993)
Type I receptors specify growth-inhibitory and transcriptional responses to transforming growth factor beta and activin. (PubMed id 8196624)^{1, 3, 4} Carcamo J....Massague J. (1994)
Ttrap is an essential modulator of Smad3-dependent Nodal signaling during zebrafish gastrulation and left-right axis determination. (PubMed id 18039968)^{3, 4} Esguerra C.V....Huylebroeck D. (2007)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Identification of the phosphotyrosine proteome from thrombin activated platelets. (PubMed id 12112843)^{3, 4} Maguire P.B....Fitzgerald D.J. (2002)
Genomic structure and cloned cDNAs predict that four variants in the kinase domain of serine/threonine kinase receptors arise by alternative splicing and poly(A) addition. (PubMed id 8058741)^{3, 4} Xu J.... McKeehan W.L. (1994)
Identification of a functional binding site for activin on the type I receptor ALK4. (PubMed id 12665502)^{1, 3} Harrison C.A....Vale W. (2003)
ACVR1B (ALK4, activin receptor type 1B) gene mutations in pancreatic carcinoma. (PubMed id 11248065)^{1, 3} Su G.H....Kern S.E. (2001)
An activin mutant with disrupted ALK4 binding blocks signaling via type II receptors. (PubMed id 15123686)^{1, 3} Harrison C.A....Vale W. (2004)
Activation of signalling by the activin receptor complex. (PubMed id 8622651)^{1, 3} Attisano L....Massague J. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 91	HGNC: 172	AceView: ACVR1B	Ensembl:ENSG00000135503	euGenes: HUgn91
ECgene: ACVR1B	H-InvDB: ACVR1B

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for ACVR1B	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for ACVR1B
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ACVR1B:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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ACVR1B Gene at Home site.
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ACVR1B Gene

protein-coding GIFtS: 60

Aliases &
Descriptions
for ACVR1B

Summaries
for ACVR1B

Genomic Location
for ACVR1B

Proteins
for ACVR1B

Protein Domains/
Families
for ACVR1B

Gene Function
for ACVR1B

Pathways & Interactions
for ACVR1B

Drugs & Compounds
for ACVR1B

Transcripts
for ACVR1B

Expression
for ACVR1B

Orthologs
for ACVR1B

Paralogs
for ACVR1B

SNPs/Variants
for ACVR1B

Disorders & Mutations
for ACVR1B

Medical News
for ACVR1B

Publications
for ACVR1B

Search for ACVR1B

Genome Databases showing ACVR1B

Other Databases showing ACVR1B

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Licensable Technologies
for ACVR1B

Services
for ACVR1B

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ACVR1B Gene

protein-coding GIFtS: 60

Aliases & Descriptionsfor ACVR1B

Summariesfor ACVR1B

Genomic Locationfor ACVR1B

Proteinsfor ACVR1B

Protein Domains/Familiesfor ACVR1B

Gene Functionfor ACVR1B

Pathways & Interactionsfor ACVR1B

Drugs & Compoundsfor ACVR1B

Transcriptsfor ACVR1B

Expression for ACVR1B

Orthologsfor ACVR1B

Paralogsfor ACVR1B

SNPs/Variantsfor ACVR1B

Disorders & Mutationsfor ACVR1B

Medical Newsfor ACVR1B

Publicationsfor ACVR1B

Search for ACVR1B

Genome Databases showing ACVR1B

Other Databases showing ACVR1B

Specialized Databases showing ACVR1B

Licensable Technologiesfor ACVR1B

Servicesfor ACVR1B

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ACVR1B

Summaries
for ACVR1B

Genomic Location
for ACVR1B

Proteins
for ACVR1B

Protein Domains/
Families
for ACVR1B

Gene Function
for ACVR1B

Pathways & Interactions
for ACVR1B

Drugs & Compounds
for ACVR1B

Transcripts
for ACVR1B

Expression
for ACVR1B

Orthologs
for ACVR1B

Paralogs
for ACVR1B

SNPs/Variants
for ACVR1B

Disorders & Mutations
for ACVR1B

Medical News
for ACVR1B

Publications
for ACVR1B

Licensable Technologies
for ACVR1B

Services
for ACVR1B