Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ACVR1B Gene

protein-coding   GIFtS: 71
GCID: GC12P052375

Activin A Receptor, Type IB


(Previous symbol: ACVRLK4)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Activin A Receptor, Type IB1 2     ACTRIB2
ACVRLK41 2 3 5     Activin A Receptor, Type II-Like Kinase 42
ALK42 3 5     Activin Receptor Type-1B2
Activin Receptor-Like Kinase 42 3     ACTR-IB3
Serine/Threonine-Protein Kinase Receptor R22 3     ALK-43
SKR22 3     Activin Receptor Type IB3
EC 2.7.11.303 8     EC 2.7.118

External Ids:    HGNC: 1721   Entrez Gene: 912   Ensembl: ENSG000001355037   OMIM: 6013005   UniProtKB: P368963   

Export aliases for ACVR1B gene to outside databases

Previous GC identifers: GC12M052557 GC12P052062 GC12P050631 GC12P050494 GC12P049378


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ACVR1B Gene:
This gene encodes an activin A type IB receptor. Activins are dimeric growth and differentiation factors which
belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins.
Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and
two type II receptors. This protein is a type I receptor which is essential for signaling. Mutations in this gene
are associated with pituitary tumors. Alternate splicing results in multiple transcript variants.(provided by
RefSeq, Jun 2010)

GeneCards Summary for ACVR1B Gene: 
ACVR1B (activin A receptor, type IB) is a protein-coding gene. Diseases associated with ACVR1B include pituitary tumors, and pancreatic cancer, and among its related super-pathways are Regulation of Signaling by NODAL and Apoptosis Pathway. GO annotations related to this gene include protein serine/threonine kinase activity and SMAD binding. An important paralog of this gene is ACVR1C.

UniProtKB/Swiss-Prot: ACV1B_HUMAN, P36896
Function: Transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with
activin receptor type-2 (ACVR2A or ACVR2B). Transduces the activin signal from the cell surface to the cytoplasm
and is thus regulating a many physiological and pathological processes including neuronal differentiation and
neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing,
extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a
paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, type-2 receptors
(ACVR2A and/or ACVR2B) act as a primary activin receptors whereas the type-1 receptors like ACVR1B act as
downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates
its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor
such as ACVR1B. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3,
on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent
phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner
SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription.
Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3
with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also
antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor. ACVR1B also
phosphorylates TDP2

summary for ACVR1B Gene:
Activin receptors transduce signals carried by the TGF-beta family of ligands. Such ligands include activin
and bone morphogenetic proteins (BMPs). Members of this family are involved in a range of processes,
including embryogenesis and tissue homeostasis.

Gene Wiki entry for ACVR1B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.2  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ACVR1B gene promoter:
         GR   AML1a   ATF-2   Brachyury   IRF-1   LCR-F1   E47   Hand1   GR-alpha   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidACVR1B promoter sequence
   Search SABiosciences Chromatin IP Primers for ACVR1B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ACVR1B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13   Ensembl cytogenetic band:  12q13.13   HGNC cytogenetic band: 12q13

ACVR1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ACVR1B gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P052375:  view genomic region     (about GC identifiers)

Start:
52,345,451 bp from pter      End:
52,390,863 bp from pter
Size:
45,413 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ACV1B_HUMAN, P36896 (See protein sequence)
Recommended Name: Activin receptor type-1B precursor  
Size: 505 amino acids; 56807 Da
Cofactor: Magnesium or manganese (By similarity)
Subunit: Forms an activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B). Interacts with TDP2
(By similarity). Interacts with AIP1, FKBP1A, IGSF1, TDGF1, SMAD2, SMAD3 and SMAD7
Subcellular location: Cell membrane; Single-pass type I membrane protein (By similarity)
Secondary accessions: B7Z5L8 B7Z5W5 Q15479 Q15480 Q15481 Q15482
Alternative splicing: 5 isoforms:  P36896-1   P36896-2   P36896-3   P36896-4   P36896-5   (Variant in position: 478:R->H)

Explore the universe of human proteins at neXtProt for ACVR1B: NX_P36896

Explore proteomics data for ACVR1B at MOPED 

Post-translational modifications:

  • UniProtKB: Autophosphorylated. Phosphorylated by activin receptor type-2 (ACVR2A or ACVR2B) in response to activin-binding at
    serine and threonine residues in the GS domain. Phosphorylation of ACVR1B by activin receptor type-2 regulates
    association with SMAD7
  • UniProtKB: Ubiquitinated. Level of ubiquitination is regulated by the SMAD7-SMURF1 complex
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P36896

  • 4/15 DME Specific Peptides for ACVR1B (P36896) (see all 15)
     IADLGLA  YMAPEVL  ASGLAHLH  RVGTKRYM 

    ACVR1B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ACVR1B Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_004293.1  NP_064732.3  NP_064733.3  

    ENSEMBL proteins: 
     ENSP00000257963   ENSP00000442656   ENSP00000390477   ENSP00000443218   ENSP00000397550  
     ENSP00000442885  
    Reactome Protein details: P36896
    Human Recombinant Protein Products for ACVR1B: 
    EMD Millipore Purified and/or Recombinant ACVR1B Protein
    R&D Systems Recombinant & Natural Proteins for ACVR1B (Activin RIB/ALK-4)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for ACVR1B
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for ACVR1B
    GenScript Custom Purified and Recombinant Proteins Services for ACVR1B
    Novus Biologicals ACVR1B Proteins
    Novus Biologicals ACVR1B Lysates
    Sino Biological Recombinant Protein for ACVR1B
    Sino Biological Cell Lysate for ACVR1B 
    ProSpec Recombinant Protein for ACVR1B
    Cloud-Clone Corp. Proteins for ACVR1B 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane IDA9032295
    GO:0009986cell surface IDA12665502
    GO:0016020membrane ----

    ACVR1B for ontologies           About GeneDecksing



    ACVR1B Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of ACVR1B
    R&D Systems Antibodies for ACVR1B (Activin RIB/ALK-4)
    OriGene Antibodies for ACVR1B
    OriGene Custom Antibody Services for ACVR1B
    GenScript Custom Superior Antibodies Services for ACVR1B
    Novus Biologicals ACVR1B Antibodies
    Abcam antibodies for ACVR1B
    Cloud-Clone Corp. Antibodies for ACVR1B 
    ThermoFisher Antibodies for ACVR1B
    LSBio Antibodies in human, mouse, rat for ACVR1B 

    Assay Products for ACVR1B: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ACVR1B
    Browse R&D Systems for biochemical assays
    GenScript ACVR1B-Activity-based Kinase Assay for Compound Screening
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ACVR1B 
    Cloud-Clone Corp. CLIAs for ACVR1B


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: activin A receptor, type IB 
    Type I receptor serine/threonine kinases
    Type I subfamily

    5/6 InterPro protein domains (see all 6):
     IPR017441 Protein_kinase_ATP_BS
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR003605 TGF_beta_rcpt_GS
     IPR000472 Activin_rcpt

    Graphical View of Domain Structure for InterPro Entry P36896

    ProtoNet protein and cluster: P36896

    1 Blocks protein domain: IPB000472 Domain in TGF-beta receptor/activin receptor

    UniProtKB/Swiss-Prot: ACV1B_HUMAN, P36896
    Domain: The GS domain is a 30-amino-acid sequence adjacent to the N-terminal boundary of the kinase domain and
    highly conserved in all other known type-1 receptors but not in type-2 receptors. The GS domain is the site of
    activation through phosphorylation by the II receptors
    Similarity: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily
    Similarity: Contains 1 GS domain
    Similarity: Contains 1 protein kinase domain


    ACVR1B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ACV1B_HUMAN, P36896
    Function: Transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with
    activin receptor type-2 (ACVR2A or ACVR2B). Transduces the activin signal from the cell surface to the cytoplasm
    and is thus regulating a many physiological and pathological processes including neuronal differentiation and
    neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing,
    extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a
    paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, type-2 receptors
    (ACVR2A and/or ACVR2B) act as a primary activin receptors whereas the type-1 receptors like ACVR1B act as
    downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates
    its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor
    such as ACVR1B. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3,
    on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent
    phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner
    SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription.
    Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3
    with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also
    antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor. ACVR1B also
    phosphorylates TDP2
    Catalytic activity: ATP + [receptor-protein] = ADP + [receptor-protein] phosphate
    Enzyme regulation: Activin receptor type-2 (ACVR2A or ACVR2B) activates the type-1 receptor through
    phosphorylation of its regulatory GS domain

         Genatlas biochemistry entry for ACVR1B:
    activin A receptor,type IB

         Enzyme Numbers (IUBMB): EC 2.7.11.301 2 EC 2.7.112

         Gene Ontology (GO): 5/17 molecular function terms (GO ID links to tree view) (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IDA12065756
    GO:0004675transmembrane receptor protein serine/threonine kinase activity NAS9032295
    GO:0004702receptor signaling protein serine/threonine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
         
    ACVR1B for ontologies           About GeneDecksing


    Phenotypes:
         12 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Acvr1b):
     cellular  craniofacial  digestive/alimentary  embryogenesis  endocrine/exocrine gland 
     growth/size  integument  mortality/aging  nervous system  no phenotypic analysis 
     reproductive system  respiratory system 

    ACVR1B for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for ACVR1B: Acvr1btm1Enl Acvr1btm1.1Pbe

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ACVR1B 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ACVR1B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ACVR1B 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ACVR1B 

    miRNA
    Products:
        
    miRTarBase miRNAs that target ACVR1B:
    hsa-mir-210 (MIRT003185), hsa-mir-24 (MIRT003830)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ACVR1B
    8/92 QIAGEN miScript miRNA Assays for microRNAs that regulate ACVR1B (see all 92):
    hsa-miR-642a hsa-miR-106a hsa-miR-218-1* hsa-miR-574-3p hsa-miR-371-5p hsa-miR-3142 hsa-miR-629* hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidACVR1B 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ACVR1B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ACVR1B

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ACVR1B
    Sirion Biotech Customized adenovirus for overexpression of ACVR1B

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for ACVR1B (see all 16)
    OriGene ORF clones in mouse, rat for ACVR1B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): ACVR1B (NM_004302)
    Sino Biological Human cDNA Clone for ACVR1B
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ACVR1B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACVR1B
    Sirion Biotech Customized lentivirus for stable overexpression of ACVR1B 
                         Customized lentivirus expression plasmids for stable overexpression of ACVR1B 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ACVR1B
    Search LifeMap BioReagents cell lines for ACVR1B
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACVR1B


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ACVR1B About   (see all 12)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Signaling by NODAL
    Signaling by NODAL0.56
    Signaling by Activin0.36
    Regulation of Signaling by NODAL0.56
    2Apoptosis Pathway
    Apoptosis Pathway0.45
    Akt Pathway0.39
    NF-kappaB Pathway0.45
    3Human Embryonic Stem Cell Pluripotency
    Human Embryonic Stem Cell Pluripotency0.50
    Factors Promoting Cardiogenesis in Vertebrates0.50
    4Axon guidance
    Developmental Biology0.69
    5Signaling by GPCR
    Signal Transduction0.55

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for ACVR1B
        Development Role of Activin A in cell differentiation and proliferation
    Signal transduction Activin A signaling regulation

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ACVR1B
        Factors Promoting Cardiogenesis in Vertebrates
    Human Embryonic Stem Cell Pluripotency

    4 Tocris Bioscience Pathways for ACVR1B
        Akt Pathway
    Apoptosis Pathway
    TGF-beta Pathway
    NF-kappaB Pathway

    2 GeneGo (Thomson Reuters) Pathways for ACVR1B
        Signal transduction Activin A signaling regulation
    Development Role of Activin A in cell differentiation and proliferation

    1 BioSystems Pathway for ACVR1B
        MAPK signaling pathway

    1 Sino Biological Pathway for ACVR1B 
        TGF-beta Signaling Pathway

    5        Reactome Pathways for ACVR1B
        Signaling by Activin
    Developmental Biology
    Signal Transduction
    Signaling by NODAL
    Regulation of Signaling by NODAL


    2         Kegg Pathways  (Kegg details for ACVR1B):
        Cytokine-cytokine receptor interaction
    TGF-beta signaling pathway


    ACVR1B for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ACVR1B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/30 Interacting proteins for ACVR1B (P368961, 3 ENSP000002579634) via UniProtKB, MINT, STRING, and/or I2D (see all 30)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD7O151053, ENSP000002621584I2D: score=4 STRING: ENSP00000262158
    ACVR2BQ137053, ENSP000003403614I2D: score=3 STRING: ENSP00000340361
    SMAD2Q157963, ENSP000002621604I2D: score=3 STRING: ENSP00000262160
    SNX2O607493, ENSP000003688314I2D: score=3 STRING: ENSP00000368831
    FKBP1AP629423, ENSP000003711384I2D: score=2 STRING: ENSP00000371138
    About this table

    Gene Ontology (GO): 5/23 biological process terms (GO ID links to tree view) (see all 23):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle IDA11117535
    GO:0001701in utero embryonic development IEA--
    GO:0001942hair follicle development IEA--
    GO:0006355regulation of transcription, DNA-dependent IDA12665502
    GO:0006468protein phosphorylation IDA12065756

    ACVR1B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ACVR1B for compounds           About GeneDecksing

    EMD Millipore small molecules for ACVR1B:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for ACVR1B available from Tocris Bioscience    About this table
    CompoundAction CAS #
    AlantolactoneAntiproliferative; induces activin/SMAD3 signaling[546-43-0]
    DMH-1BMP inhibitor; selectively inhibits ALK2[1206711-16-1]

    4 HMDB Compounds for ACVR1B    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--
    Manganesemanganese 7439-96-5--

    1 DrugBank Compound for ACVR1B    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Adenosine triphosphate5'-ATP (see all 8)56-65-5target--17139284 17016423

    3 Novoseek inferred chemical compound relationships for ACVR1B gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    threonine 67.2 4 12853652 (1), 12682303 (1), 11909953 (1), 12665502 (1)
    serine 56.4 6 10746731 (1), 12853652 (1), 12682303 (1), 12665502 (1)
    alanine 6.48 1 12665502 (1)

    Search CenterWatch for drugs/clinical trials and news about ACVR1B / ACV1B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ACVR1B gene (3 alternative transcripts): 
    NM_004302.4  NM_020327.3  NM_020328.3  

    Unigene Cluster for ACVR1B:

    Activin A receptor, type IB
    Hs.438918  [show with all ESTs]
    Unigene Representative Sequence: NM_020328
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000257963(uc010snn.2 uc001rzn.3 uc021qya.1) ENST00000541224
    ENST00000426655(uc001rzm.3) ENST00000536420 ENST00000415850(uc001rzl.3)
    ENST00000542485 ENST00000563121
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ACVR1B
    8/92 QIAGEN miScript miRNA Assays for microRNAs that regulate ACVR1B (see all 92):
    hsa-miR-642a hsa-miR-106a hsa-miR-218-1* hsa-miR-574-3p hsa-miR-371-5p hsa-miR-3142 hsa-miR-629* hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidACVR1B 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ACVR1B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ACVR1B
    Clone
    Products:
         
    OriGene clones in human, mouse for ACVR1B (see all 16)
    OriGene ORF clones in mouse, rat for ACVR1B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): ACVR1B (NM_004302)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ACVR1B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACVR1B
    Sirion Biotech Customized lentivirus for stable overexpression of ACVR1B 
                         Customized lentivirus expression plasmids for stable overexpression of ACVR1B 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ACVR1B
    OriGene qSTAR qPCR primer pairs in human, mouse for ACVR1B
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ACVR1B
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ACVR1B
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ACVR1B

    Additional mRNA sequence: 

    AK299120.1 AK299496.1 AL117643.1 BC000254.1 BC034008.1 BC040531.1 BT007072.1 L10125.1 
    L10126.1 U14722.1 Z22536.1 

    7 DOTS entries:

    DT.86845897  DT.100771615  DT.101976747  DT.87046577  DT.40220232  DT.75155814  DT.95330621 

    24/164 AceView cDNA sequences (see all 164):

    Z22536 BT007072 AA480376 AW026270 AA902887 AL709104 AI359300 AW614156 
    BU949388 BU943859 BF590767 BE222346 AI192922 AW772334 AA687606 NM_004302 
    BE468035 BE222288 BU949145 BX099760 BX956834 BE220397 BF740083 AA541401 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ACVR1B expression in normal human tissues (normalized intensities)      ACVR1B embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ACVR1B Expression
    About this image


    ACVR1B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Cerebral Cortex
             superior temporal gyrus   
     
     Thyroid (Endocrine System)
             parathyroid gland   
     
     Trophoblast (Extraembryonic Tissues)
             Extraembryonic Ectoderm Cells Extraembryonic Ectoderm
     
     Tooth (Integumentary System)
             Dental Placode Cells Dental Placode

    See ACVR1B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ACVR1B

    SOURCE GeneReport for Unigene cluster: Hs.438918

    UniProtKB/Swiss-Prot: ACV1B_HUMAN, P36896
    Tissue specificity: Expressed in many tissues, most strongly in kidney, pancreas, brain, lung, and liver

        SABiosciences Expression via Pathway-Focused PCR Arrays including ACVR1B: 
              Stem Cell Signaling in human mouse rat
              Apoptosis 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ACVR1B
    OriGene qSTAR qPCR primer pairs in human, mouse for ACVR1B
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ACVR1B
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ACVR1B
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ACVR1B
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACVR1B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ACVR1B gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Acvr1b1 , 5 activin A receptor, type 1B1, 5 90.83(n)1
    98.22(a)1
      15 (56.48 cM)5
    114791  NM_007395.31  NP_031421.11 
     1011741255 
    chicken
    (Gallus gallus)
    Aves ACVR1B1 activin A receptor, type IB 81.6(n)
    91.87(a)
      768878  XM_001231300.2  XP_001231301.2 
    lizard
    (Anolis carolinensis)
    Reptilia ACVR1B6
    activin A receptor, type IB
    85(a)
    1 ↔ 1
    2(92635380-92671021)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.10582 Xenopus laevis activin receptor-like kinase 4 (XALK4) more 79.94(n)    U60643.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tarama2 tarama 78.86(n)   30183  NM_130990.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta babo3 TGFbeta ligand binding to type I
    receptor protein more
    53(a)
    (best of 2)
      44F12   --


    ENSEMBL Gene Tree for ACVR1B (if available)
    TreeFam Gene Tree for ACVR1B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ACVR1B gene
    ACVR1C2  TGFBR22  AMHR22  ACVR2B2  ACVR2A2  TGFBR12  BMPR1A2  ACVR12  
    ACVRL12  BMPR22  BMPR1B2  
    8 SIMAP similar genes for ACVR1B using alignment to 2 protein entries:     ACV1B_HUMAN (see all proteins):
    ACVR1C    TGFBR1    BMPR1B    ACVRL1    ACVR1    BMPR1A
    ACVR2A    TGFBR2

    ACVR1B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/821 SNPs in ACVR1B are shown (see all 821)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs97955551,2
    C--49420464(+) AAAAAC/GGAAGA 3 -- int1 trp30--------
    rs619140281,2
    C,F--52177839(+) AATTCG/ATGTCT 2 -- us2k15Minor allele frequency- A:0.19NA WA EA 362
    rs1866245181,2
    --52177939(+) AGGGTG/TGGCCC 2 -- us2k10--------
    rs1927354991,2
    --52177952(+) ATCCAA/GTGACT 2 -- us2k10--------
    rs1466939071,2
    --52178127(+) CAGAGA/TGCACA 2 -- us2k10--------
    rs1854441511,2
    --52178187(+) GAGAAG/TACATT 2 -- us2k10--------
    rs1403037271,2
    --52178629(+) GTTAGG/TAGGAA 2 -- us2k10--------
    rs1453651251,2
    --52178704(+) TTCTCA/TAGCTA 2 -- us2k10--------
    rs1162906871,2
    F--52178746(+) AGTGAT/CTTGTT 2 -- us2k11Minor allele frequency- C:0.01WA 118
    rs1153298851,2
    F--52178747(+) GTGATT/CTGTTT 2 -- us2k11Minor allele frequency- C:0.01WA 118

    HapMap Linkage Disequilibrium report for ACVR1B (52345451 - 52390863 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for ACVR1B:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2745889CNV Deletion23290073
    esv5144CNV Deletion18987735
    esv2745890CNV Deletion23290073
    esv2674142CNV Deletion23128226
    nsv525457CNV Loss19592680


    Human Gene Mutation Database (HGMD): ACVR1B
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ACVR1B
    DNA2.0 Custom Variant and Variant Library Synthesis for ACVR1B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601300    OMIM disorders: --

    UniProtKB/Swiss-Prot: ACV1B_HUMAN, P36896
  • Note=ACVRIB is abundantly expressed in systemic sclerosis patient fibroblasts and production of collagen
    is also induced by activin-A/INHBA. This suggests that the activin/ACRV1B signaling mechanism is involved in
    systemic sclerosis

  • 20 diseases for ACVR1B:    About MalaCards
    pituitary tumors    pancreatic cancer    traumatic brain injury    brain injury
    goiter    eclampsia    pre-eclampsia    pituitary adenoma
    pheochromocytoma    pancreatitis    adenoma    asthma
    neuroblastoma    schizophrenia    retinitis    colorectal cancer
    thyroiditis    prostate cancer    prostatitis    neuronitis


    ACVR1B for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for ACVR1B gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pancreatic cancer 8.9 2 11248065 (1), 9714055 (1)
    tumors 0 1 8636304 (1)
    cancer 0 3 15753386 (1), 9714055 (1), 11511564 (1)

    Genetic Association Database (GAD): ACVR1B
    Human Genome Epidemiology (HuGE) Navigator: ACVR1B (5 documents)

    Export disorders for ACVR1B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ACVR1B gene, integrated from 9 sources (see all 119):
    (articles sorted by number of sources associating them with ACVR1B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity. (PubMed id 8397373)1, 2, 3, 9 ten Dijke P.... Miyazono K. (1993)
    2. Identification of a functional binding site for activin on the type I receptor ALK4. (PubMed id 12665502)1, 2, 9 Harrison C.A....Vale W. (2003)
    3. Activation of signalling by the activin receptor complex. (PubMed id 8622651)1, 2, 9 Attisano L....Massague J. (1996)
    4. Type I receptors specify growth-inhibitory and transcriptional responses to transforming growth factor beta and activin. (PubMed id 8196624)1, 2, 9 Carcamo J....Massague J. (1994)
    5. Cripto-1 activates nodal- and ALK4-dependent and -independent signaling pathways in mammary epithelial Cells. (PubMed id 11909953)1, 2, 9 Bianco C....Salomon D.S. (2002)
    6. Activin A induces neuronal differentiation and surviv al via ALK4 in a SMAD-independent manner in a subpopulation of human neuroblast omas. (PubMed id 20226172)1, 2, 9 Suzuki K....Ikekita M. (2010)
    7. Activin signaling through type IB activin receptor stimulates aromatase activity in the ovarian granulosa cell-like human granulosa (KGN) cells. (PubMed id 12639945)1, 2, 9 Mukasa C....Nawata H. (2003)
    8. Modulation of activin signal transduction by inhibin B and inhibin- binding protein (INhBP). (PubMed id 11266516)1, 2, 9 Chapman S.C. and Woodruff T.K. (2001)
    9. FKBP12 functions as an adaptor of the Smad7-Smurf1 complex on activin type I receptor. (PubMed id 16720724)1, 2, 9 Yamaguchi T....Sugino H. (2006)
    10. Activation of the activin A-ALK-Smad pathway in systemic sclerosis. (PubMed id 21377836)1, 2 Takagi K.... Yamanaka H. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 91 HGNC: 172 AceView: ACVR1B Ensembl:ENSG00000135503 euGenes: HUgn91
    ECgene: ACVR1B Kegg: 91 H-InvDB: ACVR1B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ACVR1B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ACVR1B Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ACVR1B gene:
    Search GeneIP for patents involving ACVR1B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     EMD Millipore Mono- and Polyclonal Antibodies for the study of ACVR1B
     EMD Millipore Purified and/or Recombinant ACVR1B Protein
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore small molecules (inhibitor) for ACVR1B
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for ACVR1B (Activin RIB/ALK-4)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Recombinant/Natural Proteins for ACVR1B (Activin RIB/ALK-4)  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for ACVR1B   OriGene RNAi products in human, mouse, rat for ACVR1B  
     OriGene qPCR primer pairs and template standards for ACVR1B   OriGene Protein Over-expression Lysate for ACVR1B  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for ACVR1B  
     OriGene qSTAR qPCR primer pairs in human, mouse for ACVR1B   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for ACVR1B   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ACVR1B   OriGene Custom Protein Services for ACVR1B  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ACVR1B
     QIAGEN SeqTarget long-range PCR primers for resequencing ACVR1B
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ACVR1B
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ACVR1B
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ACVR1B
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ACVR1B
     GenScript Custom Purified and Recombinant Proteins Services for ACVR1B GenScript cDNA clones with any tag delivered in your preferred vector for ACVR1B
     GenScript ACVR1B-Activity-based Kinase Assay for Compound Screening GenScript Custom Superior Antibodies Services for ACVR1B
     GenScript Custom overexpressing Cell Line Services for ACVR1B CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in ACVR1B promoter
     Search Chromatin IP Primers for ACVR1B
     RT2 qPCR Primer Assay in human, mouse, rat ACVR1B
     GNC Network for ACVR1B
     SABiosciences PCR Arrays including human, mouse, rat ACVR1B
     Tocris compounds for ACVR1B
     Proteins and Antibodies for ACVR1B
     Cell Lysates for ACVR1B
     cDNA Clones for ACVR1B
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     ACVR1B antibodies
     ACVR1B proteins
     ACVR1B lysates
     Antibodies for ACVR1B
     See all of Abcam's Antibodies, Kits and Proteins for ACVR1B
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for ACVR1B




     Proteins for ACVR1B
     Antibodies for ACVR1B
     ELISAs for ACVR1B
     CLIAs for ACVR1B
     Search LifeMap BioReagents cell lines for ACVR1B
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACVR1B
     SwitchGear 3'UTR luciferase reporter plasmids for ACVR1B
     SwitchGear Promoter luciferase reporter plasmids for ACVR1B
     ThermoFisher Antibodies for ACVR1B
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACVR1B
     inGenious Targeting Laboratory - Custom generated mouse model solutions for ACVR1B
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ACVR1B
    Customized:
     lentivirus for stable overexpression of ACVR1B
     lentivirus expression plasmids for stable overexpression of ACVR1B
     adenovirus for overexpression of ACVR1B
     LSBio Antibodies in human, mouse, rat for ACVR1B
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ACVR1B gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4