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ACVR1 Gene

protein-coding   GIFtS: 66

GC02M158301
activin A receptor, type I
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: ACVRLK2)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
ACTR-I 3
ACTRI 2
ACVR1A 1, 2
ACVRLK2 2, 3, 5
ALK-2 3
ALK2 1, 2, 5
EC 2.7.11.30 3
FOP 2, 5
SKR1 1, 2, 3
TSR-I 3
TSRI 2
Descriptions
Activin receptor type I 3
Activin receptor-like kinase 2 3
Serine/threonine-protein kinase receptor R1 2, 3
TGF-B superfamily receptor type I 2, 3
activin A receptor, type I 2
activin A receptor, type II-like kinase 2 2
hydroxyalkyl-protein kinase 2
External Ids
HGNC: 1711
Entrez Gene: 902
UniProtKB: Q047713
Ensembl: ENSG000001151707
Search outside databases for aliases for ACVR1 gene

Previous GC identifers: GC02M156524 GC02M157121 GC02M158557 GC02M158795 GC02M158418

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ACVR1:
Activins are dimeric growth and differentiation factors which belong to the transforming growth
factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal
through a heteromeric complex of receptor serine kinases which include at least two type I ( I and
IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins,
composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane
domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are
essential for signaling; and type II receptors are required for binding ligands and for expression
of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting
in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I
receptor which signals a particular transcriptional response in concert with activin type II
receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive.
[provided by RefSeq]

UniProtKB/Swiss-Prot: ACVR1_HUMAN, Q04771
Function: On ligand binding, forms a receptor complex consisting of two type II and two type I
transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I
receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators.
Receptor for activin. May be involved for left-right pattern formation during embryogenesis (By
similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the ACVR1 gene  

Entrez Gene cytogenetic band: 2q23-q24   Ensembl cytogenetic band:  2q24.1   HGNC cytogenetic band: 2q23-q24

ACVR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M158301:     (about GC identifiers)

Start:
158,301,207 bp from pter
End:
158,440,598 bp from pter
Size:
139,392 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000002.10  NT_005403.16  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ACVR1_HUMAN, Q04771 (See protein sequence)
Recommended Name: Activin receptor type-1 precursor  
Size: 509 amino acids; 57153 Da
Cofactor: Magnesium or manganese (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (2 alternative transcripts): 
    NP_001096.1  NP_001104537.1  


    ENSEMBL proteins: 
    ENSP00000263640 ENSP00000387273 ENSP00000387127 


    Human Recombinant Proteins 
    Invitrogen human recombinant proteins for ACVR1
    Browse Purified and Recombinant Proteins at Millipore
    Sigma-Aldrich Proteins for ACVR1  
    R&D Systems Recombinant & Natural Proteins for ACVR1 (Activin RIA/ALK-2)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (Activin Receptor Type IA)
    Human Recombinant Proteins from Abnova (ACVR1)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    3 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016020 membrane IEA--
    GO:0045177 apical part of cell IEA--
    GO:0048179 activin receptor complex IDA8242742
    About this table

    Antibodies for ACVR1: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for ACVR1
    R&D Systems Antibodies for ACVR1 (Activin RIA/ALK-2)
    Antibodies from Abcam (Activin Receptor Type IA), each with their AbpromiseSM
    Browse Abnova for Monoclonal and Polyclonal Antibodies
    Novus Biologicals Antibodies for ACVR1

    Assays for ACVR1: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    5/7 InterPro domains/families (see all 7 ):
     IPR017441 Protein_kinase_ATP_BS
     IPR017442 Se/Thr_pkinase-rel
     IPR008271 Ser_thr_pkin_AS
     IPR003605 TGF_beta_rcpt_GS
     IPR000472 Activin_rcpt


       GeneDecks  ACVR1 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q04771

    ProtoNet protein and cluster: Q04771

    1 Blocks protein family: IPB000472 Domain in TGF-beta receptor/activin receptor

    UniProtKB/Swiss-Prot: ACVR1_HUMAN, Q04771
    Similarity: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB
    receptor subfamily
    Similarity: Contains 1 GS domain
    Similarity: Contains 1 protein kinase domain

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (ACVR1)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (ACVR1)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001111067

                  Applied Biosystems Silencer® siRNAs for ACVR1

                  Sigma-Aldrich siRNA and siRNA Panels for ACVR1  
                         Sigma-Aldrich shRNA Panels and shRNA for ACVR1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for ACVR1
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001105
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001105
                                     untagged cDNA clones in CMV expression vector (see all 3): NM_001105 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_001111067

    UniProtKB/Swiss-Prot: ACVR1_HUMAN, Q04771
    Function: On ligand binding, forms a receptor complex consisting of two type II and two type I
    transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I
    receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators.
    Receptor for activin. May be involved for left-right pattern formation during embryogenesis (By
    similarity)
    Catalytic activity: ATP + [receptor-protein] = ADP + [receptor-protein] phosphate
    Enzyme Number (IUBMB): EC 2.7.11.30 

    Genatlas biochemistry entry for ACVR1:
    activin receptor type 1,member of transforming growth factor beta superfamily

    10 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Acvr1):

    behavior/neurologicalcraniofacialdigestive/alimentaryembryogenesis
    growth/sizehearing/vestibular/earlethality-prenatal/perinatalnervous systemskeleton

    5/12 Gene Ontology (GO) molecular function terms (links to tree view) (see all 12 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166 nucleotide binding IEA--
    GO:0000287 magnesium ion binding IEA--
    GO:0004872 receptor activity IEA--
    GO:0005524 ATP binding IDA12065756
    GO:0016361contributes to activin receptor activity, type I IDA8242742
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    1 Invitrogen iPath™ Online BioAtlas - Pathway for ACVR1 (Maps provided by GeneGo):
     Role of BMP-SMAD pathway in heart development

       GeneDecks  ACVR1 for the pathways selected above  
    About GeneDecksing

    4 Sigma-Aldrich "Your Favorite Gene" Pathways for  ACVR1  (Your Favorite Gene powered by Ingenuity) 
     PPAR&alpha
     Wnt/&beta
     Factors Promoting Cardiogenesis in Vertebrates
     TGF-&beta

       GeneDecks  ACVR1 for the pathways selected above  
    About GeneDecksing

    2 Kegg Pathways  (Kegg details for ACVR1):
     hsa04060 Cytokine-cytokine receptor interaction
     hsa04350 TGF-beta signaling pathway

       GeneDecks  ACVR1 for the pathways selected above  
    About GeneDecksing
     Gene Network CentralTM Interacting Genes and Proteins Network for  ACVR1 


    5/51 Interacting proteins for ACVR1 (ENSP000002636403 Q047712) via UniProtKB, MINT, and/or STRING (see all 51 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    INHBEENSP000002666463STRING (score=.997)
    AMHENSP000002214963STRING (score=.991)
    BMP2ENSP000003681043STRING (score=.987)
    BMP7ENSP000003603403STRING (score=.987)
    SMAD5ENSP000002315893STRING (score=.987)
    About this table

    5/24 Gene Ontology (GO) biological process terms (links to tree view) (see all 24 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082 G1/S transition of mitotic cell cycle IMP9884026
    GO:0001569 patterning of blood vessels IEA--
    GO:0001655 urogenital system development IEA--
    GO:0001701 in utero embryonic development IEA--
    GO:0001702 gastrulation with mouth forming second IEA--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for ACVR1
    2 Novoseek chemical compound relationships for ACVR1 gene
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    threonine 66.11 5 8242742 (1), 7791754 (1), 8389764 (1), 15621726 (1)
    oligonucleotide 0.00 1 8389764 (1)
    About this table


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (ACVR1)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (ACVR1)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001111067

                  Sigma-Aldrich siRNA and siRNA Panels for ACVR1  
                         Sigma-Aldrich shRNA Panels and shRNA for ACVR1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_001105  NM_001111067  

    REFSEQ mRNAs for ACVR1 gene (2 alternative transcripts): 

    NM_001105.4   NM_001111067.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_001105  NM_001111067  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001105
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001105
                                     untagged cDNA clones in CMV expression vector (see all 3): NM_001105 

    Additional cDNA sequence: 

    AK297765.1 AK313630.1 BC033867.1 BC036748.1 CR623544.1 L02911.1 Z22534.1 

    11 DOTS entries:

    DT.443257  DT.100749946  DT.91760723  DT.91838442  DT.100749947  DT.97767836  DT.97769140  DT.120984794 
    DT.40220054  DT.97804988  DT.95096700 

    24/137 AceView cDNA sequences (see all 137 ):

    CN481300 BU629124 H96913 AW613513 AI520721 L02911 N66988 BX455529 
    CD655050 R45384 BC033867 BM545650 T29135 AI493854 AW118702 BM128460 
    CR623544 BM703959 BC036748 R20290 BX505932 BM851122 AW029054 AI623705 

    highest scoring ESTs for ACVR1:

    BC033867 BC036748 L02911 Z22534 AA024668 AA025278 AA053838 AA136882 AA136910 AA298554 

    Unigene Cluster for ACVR1:

    Activin A receptor, type I
    Hs.470316  [show with all ESTs]
    Unigene Representative Sequence: BC036748


    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ACVR1

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b
    SP1:                                                                                                      
    SP2:                    -     -                                                                           
    SP3:              -     -                                                                                 
    SP4:              -     -     -                                                                           

    About this scheme

    ECgene alternative splicing isoforms for ACVR1

    3 Ensembl transcripts including schematic representations:
    ENST00000263640  ENST00000409283  ENST00000410057  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    ACVR1 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for ACVR1

    1 / 2 / 3

    3 probe-sets matching ACVR1 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    39764_at2, 3 U95-A 1 0.81 1.00 1.00 1.00 Z22534 0.80 1.00 0.91 1

    203935_at2, 3 U133-A 1 1.00 1.00 -- -- NM_001105 0.60 1.00 0.82 1

    203935_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  ACVR1 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: TGCTGATGTT

    SOURCE GeneReport for Unigene cluster: Hs.470316

    Expression variation in blood from EXPOLDB for ACVR1

    UniProtKB/Swiss-Prot: ACVR1_HUMAN, Q04771
    Tissue specificity: Expressed in normal parenchymal cells, endothelial cells, fibroblasts and
    tumor-derived epithelial cells

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for ACVR1 gene from 5/13 species (see all 13 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    ACVR11   -- activin A receptor, type I 92.86(n)
    97.62(a)
    478757  XM_851059.1  XP_856152.1 
    chimpanzee
    (Pan troglodytes)
    ACVR11   -- activin A receptor, type I 99.48(n)
    99.8(a)
    470565  XM_001145163.1  XP_001145163.1 
    cow
    (Bos taurus)
    ACVR11   -- activin A receptor, type I 93.12(n)
    99.02(a)
    338068  NM_176663.2  NP_788836.1 
    rat
    (Rattus norvegicus)
    Acvr11   -- activin A receptor, type I 89.59(n)
    97.25(a)
    79558  NM_024486.1  NP_077812.1 
    mouse
    (Mus musculus)
    Acvr11, 5 25
    activin A receptor, type 11, 5 90.77(n)1
    98.43(a)1
    114771  NM_007394.21  NP_031420.21 
     AF3320875  AF3320885  (see all 15)
    About this table        Species with no ortholog for ACVR1

    ENSEMBL Gene Tree for ACVR1
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for ACVR1 gene
    ACVRL12  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/457 NCBI SNPs in ACVR1 are shown (see all 457 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 150)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 2 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs129971,2
    A,C,F,H,O158301603(-) TGCTTT/CGTGCA 2 -- ut3114Minor allele frequency- C:0.30MN EA NA EU WA 2762
    rs129361,2
    C,F,H,O158302244(-) TCATTG/TTCCAG 2 -- ut319Minor allele frequency- T:0.04MN EU EA WA NA 673
    rs134063361,2
    C,F,H158364208(+) GGAGAG/CCAATC 2 G/A mis1 trp38Minor allele frequency- C:0.25EU EA WA 838
    rs22289481,2
    C,F,O158302151(-) ACGTCG/ATACCC 2 -- ut31 ese34Minor allele frequency- A:0.14MN NA 162
    rs28836051,2
    C,F,H158404775(+) CCAGGG/TTGTGA 1 -- ng314Minor allele frequency- T:0.03EU EA WA 416
    rs92886971,2
    C,F,H158403064(+) TGCATG/TGCTTT 1 -- ng3114Minor allele frequency- T:0.14NS NA EU EA WA 848
    rs37545921,2
    H158383226(-) TACCCC/AAGTGA 2 -- ut51 ese34Minor allele frequency- A:0.00EU EA WA 418
    --
    rs340561891,2
    C158345285(+) TCACAG/CTGGTC 2 Q/H mis14Minor allele frequency- C:0.00EU EA WA 420
    rs11460311,2
    A,C,F,H,O158335226(-) GGGGAA/GAATGT 2 E/E syn1 trp38Minor allele frequency- G:0.06EA NA EU WA 2032
    rs37389271,2
    C,F,H158302306(-) ACAAAT/CTGAAA 2 L/L syn14Minor allele frequency- C:0.03EU EA WA 414
    About this table

    HapMap Linkage Disequilibrium images for ACVR1 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 102576   disorders: 135100  

    UniProtKB/Swiss-Prot: ACVR1_HUMAN, Q04771

  • Defects in ACVR1 are a cause of fibrodysplasia ossificans progressiva (FOP) [MIM:135100].
    FOP is a rare autosomal dominant disorder of skeletal malformations and progressive extraskeletal
    ossification. Heterotopic ossification in FOP begins in childhood and can be induced by trauma or
    may occur without warning. Bone formation is episodic and progressive, leading to extra-articular
    ankylosis of all major joints of the axial and appendicular skeleton, rendering movement
    impossible
  • 7 Novoseek disease relationships for ACVR1 gene

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    fibrodysplasia ossificans progressiva 81.41 2 18019378 (1), 18245597 (1), 18684712 (1), 19400542 (1) (see all 7)
    ossification heterotopic 62.34 4 19085907 (2), 17967130 (1)
    pancreatic cancer 6.16 3 9850059 (1), 9714055 (1)
    inflammation 4.39 1 12151307 (1)
    cancer 0.00 1 9714055 (1)
    carcinoma 0.00 1 18077314 (1)
    tumors 0.00 5 8636304 (1), 17982616 (1)
    About this table

    Human Gene Mutation Database: ACVR1
    Human Genome Epidemiology Navigator: ACVR1 (4 documents)

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/122 PubMed articles for ACVR1 gene (see all 122 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 90 HGNC: 171 AceView: ACVR1 Ensembl:ENSG00000115170 euGenes: HUgn90
    ECgene: ACVR1 H-InvDB: ACVR1
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    NameDescription
    ATLAS Chromosomes in Cancer entry for ACVR1 Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.genetests.org/query?gene=ACVR1
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for ACVR1:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for ACVR1-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
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    GeneCards Homepage    -    Last full update: 1 Jul 2009        Incremental update: 13 Oct 2009

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