ACTRT3 Gene
protein-coding GIFtS: 37
GCID: GC03M169487
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actin-related protein T3
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Aliases
for ACTRT3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Actin-Related Protein T31 2 | | ARPM11 2 3 | | Actin-Related Protein M12 3 | | ARP-T32 3 | | Actin Related Protein M12 |
Export aliases for ACTRT3 gene to outside databasesPrevious GC identifer: GC03M169485 |
Summaries
for ACTRT3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for ACTRT3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_005612.16
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for ACTRT3
Other transcription factors
Search SABiosciences Chromatin IP Primers for ACTRT3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ACTRT3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q26.2 Ensembl cytogenetic band: 3q26.2 HGNC cytogenetic band: 3q26.2ACTRT3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03M169487: view genomic region
(about GC identifiers)
Start:
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169,484,709 bp from pter |
End:
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169,487,683 bp from pter |
Size:
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2,975 bases |
Orientation:
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minus strand |
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Proteins
for ACTRT3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ACTT3_HUMAN, Q9BYD9 (See
protein sequence)Recommended Name: Actin-related protein T3 Size: 372 amino acids; 41008 Da
Subunit: Interacts with PFN3 (By similarity)
Subcellular location: Cytoplasm, cytoskeleton (By similarity). Cytoplasm (By similarity). Nucleus (By similarity)
Secondary accessions: Q96IS0 Q96NJ0Explore the universe of human proteins at neXtProt for ACTRT3: NX_Q9BYD9
ACTRT3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_115876.3
ENSEMBL proteins: ENSP00000333037
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
ACTRT3 for ontologies About GeneDecksing
ACTRT3 Antibody Products:
Assay Products for ACTRT3: |
Protein
Domains /
Families
for ACTRT3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ACTRT3 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9BYD9ProtoNet protein and cluster: Q9BYD9 1 Blocks protein family: IPB004000 Actin/actin-like
UniProtKB/Swiss-Prot: ACTT3_HUMAN, Q9BYD9Similarity: Belongs to the actin family |
Function
for ACTRT3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ACTRT3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ACTRT3 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for ACTRT3 | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ACTRT3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACTRT3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACTRT3 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
-- | -- |
ACTRT3 for ontologies About GeneDecksing
|
Pathways & Interactions
for ACTRT3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ACTRT3
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
2 Interacting proteins for ACTRT3 (Q9BYD93 ENSP000003330374) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for ACTRT3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ACTRT3
Search CenterWatch for drugs/clinical trials and news about ACTRT3 / ACTT3
|
Transcripts
for ACTRT3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ACTRT3 gene: NM_032487.4 Unigene Cluster for ACTRT3: Actin-related protein T3 Hs.135411 [show with all ESTs]Unigene Representative Sequence: NM_0324871 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000330368(uc003ffs.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ACTRT3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ACTRT3 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for ACTRT3 | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ACTRT3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACTRT3 |
Additional cDNA sequence: AB049117.1 AK055346.1 BC007289.1 1 DOTS entry: DT.40133096 24/27 AceView cDNA sequences (see all 27): AA373381 AB049117 BC007289 AA948283 AK055346 NM_032487 BE552203 AI097065 BX329291 AI811210 AI290635 BG037097 BM559450 BG178280 BX374164 BI765774 AW467143 AI655508 AA402182 BE292981 BF980350 AI825441 AI655489 BU927731
GeneLoc Exon Structure
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Expression
for ACTRT3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --
See ACTRT3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ACTRT3
SOURCE GeneReport for Unigene cluster: Hs.135411
UniProtKB/Swiss-Prot: ACTT3_HUMAN, Q9BYD9Tissue specificity: Ubiquitously expressed
SABiosciences Custom PCR Arrays for ACTRT3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ACTRT3
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat ACTRT3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ACTRT3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ACTRT3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACTRT3 |
Orthologs
for ACTRT3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for ACTRT3 gene from 7/26 species (see all 26) About this table
ENSEMBL Gene Tree for ACTRT3 (if available)
TreeFam Gene Tree for ACTRT3 (if available) |
Paralogs
for ACTRT3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ACTRT3 gene
- ACTG22 ACTA22 ACTB2 ACTRT22 ACTR1A2 ACTC12 ACTL92 ACTRT12
- ACTG12 ACTL7A2 ACTBL22 ACTL7B2 ACTR1B2 ACTA12
18/27 SIMAP similar genes for ACTRT3 using alignment to 1 protein entry: ACTT3_HUMAN(see all similar genes):ACTC1 ACTG2 ACTG1 ACTA2 ACTB PS1TP5BP1
ACTBL2 ACTRT1 POTEE POTEF POTEI POTEJ
POTEKP ACTRT2 ACTR1A ACTR1B ACTL9 ACTR2
ACTRT3 for paralogs About GeneDecksing
|
Genomic Variants
for ACTRT3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ACTRT3 (169484709 - 169487683 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ACTRT3: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ACTRT3 |
|
Disorders
/ Diseases
for ACTRT3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ACTRT3 for disorders About GeneDecksing
OMIM gene information: 608534
OMIM disorders: --
1  disease for ACTRT3: About MalaCardsmalaria
Export disorders for ACTRT3 gene to outside databases
|
Publications
for ACTRT3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ACTRT3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ACTRT3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of two cDNAs for human actin-related proteins (Arps) that have remarkable similarity to conventional actin. (PubMed id 11750065)1, 2, 3 Harata M.... Hatta S. (2001)
- Nuclear localization of profilin III-ArpM1 complex in mouse spermiogenesis. (PubMed id 18692047)1, 3 Hara Y....Baba T. (2008)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for ACTRT3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing ACTRT3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ACTRT3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ACTRT3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for ACTRT3 gene:
Search GeneIP for patents involving ACTRT3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ACTRT3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ACTRT3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ACTRT3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ACTRT3 | | | OriGene Protein Over-expression Lysate for ACTRT3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ACTRT3 | | OriGene 3'-UTR Clone for ACTRT3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ACTRT3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ACTRT3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for ACTRT3 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ACTRT3 | | OriGene Custom Protein Services for ACTRT3 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ACTRT3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ACTRT3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ACTRT3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ACTRT3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ACTRT3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ACTRT3 |
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 |  |  |  | |
| | | | Search Tocris compounds for ACTRT3 |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACTRT3 |
|  |  |  | | | | Search ThermoFisher Antibodies for ACTRT3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACTRT3 |
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