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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ACTRT3 Gene

protein-coding   GIFtS: 39
GCID: GC03M169492

Actin-Related Protein T3

  Search for ACTRT3
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Actin-Related Protein T31 2
Actin Related Protein M11 2
Actin-Related Protein M12 3
ARP-T32 3
ARPM12 3

External Ids:    HGNC: 240221   Entrez Gene: 845172   Ensembl: ENSG000001843787   OMIM: 6085345   UniProtKB: Q9BYD93   

Export aliases for ACTRT3 gene to outside databases

Previous GC identifers: GC03M169485 GC03M169487


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ACTRT3 Gene: 
ACTRT3 (actin-related protein T3) is a protein-coding gene. An important paralog of this gene is ACTG2.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.2  NT_005612.16  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for ACTRT3
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for ACTRT3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ACTRT3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q26.2   Ensembl cytogenetic band:  3q26.2   HGNC cytogenetic band: 3q26.2

ACTRT3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ACTRT3 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M169492:  view genomic region     (about GC identifiers)

Start:
169,484,709 bp from pter      End:
169,487,683 bp from pter
Size:
2,975 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ACTT3_HUMAN, Q9BYD9 (See protein sequence)
Recommended Name: Actin-related protein T3  
Size: 372 amino acids; 41008 Da
Subunit: Interacts with PFN3 (By similarity)
Subcellular location: Cytoplasm, cytoskeleton (By similarity). Cytoplasm (By similarity). Nucleus (By similarity)
Secondary accessions: Q96IS0 Q96NJ0

Explore the universe of human proteins at neXtProt for ACTRT3: NX_Q9BYD9

Explore proteomics data for ACTRT3 at MOPED 

ACTRT3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

ACTRT3 Protein Expression

REFSEQ proteins: NP_115876.3  
ENSEMBL proteins: 
 ENSP00000333037  

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Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001673male germ cell nucleus IEA--
GO:0005737cytoplasm IEA--
GO:0005856cytoskeleton IEA--

ACTRT3 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
2 InterPro protein domains:
 IPR004000 Actin-related
 IPR020902 Actin/actin-like_CS

Graphical View of Domain Structure for InterPro Entry Q9BYD9

ProtoNet protein and cluster: Q9BYD9

1 Blocks protein domain: IPB004000 Actin/actin-like

UniProtKB/Swiss-Prot: ACTT3_HUMAN, Q9BYD9
Similarity: Belongs to the actin family


ACTRT3 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

     Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding ----
     
ACTRT3 for ontologies           About GeneDecksing


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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ACTRT3

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

2 Interacting proteins for ACTRT3 (Q9BYD93 ENSP000003330374) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
PFN3P606733I2D: score=1 
PFN4ENSP000003221704STRING: ENSP00000322170
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ACTRT3 (ACTT3)

Search CenterWatch for drugs/clinical trials and news about ACTRT3 / ACTT3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ACTRT3 gene: 
NM_032487.4  

Unigene Cluster for ACTRT3:

Actin-related protein T3
Hs.135411  [show with all ESTs]
Unigene Representative Sequence: NM_032487
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000330368(uc003ffs.2)
miRNA
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Additional mRNA sequence: 

AB049117.1 AK055346.1 BC007289.1 

1 DOTS entry:

DT.40133096 

24/27 AceView cDNA sequences (see all 27):

AK055346 BE552203 AA948283 AA373381 AB049117 NM_032487 BC007289 AI811210 
AI097065 BG037097 BM559450 BG178280 AI290635 AI655508 AW467143 BX374164 
BI765774 AA402182 BX329291 BF980350 AI825441 AI655489 BE292981 BU927731 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ACTRT3 expression in normal human tissues (normalized intensities)      ACTRT3 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
ACTRT3 Expression
About this image


ACTRT3 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/2 selected tissues (see all 2) fully expand
 
 Primitive Streak (Early Embryonic Tissues)
         Mesendoderm-like cells ( Generation of mesendoderm and definitive endoderm cells...
 
 Testis (Reproductive System)

See ACTRT3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ACTRT3

SOURCE GeneReport for Unigene cluster: Hs.135411

UniProtKB/Swiss-Prot: ACTT3_HUMAN, Q9BYD9
Tissue specificity: Ubiquitously expressed

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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACTRT3

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for ACTRT3 gene from 2/8 species (see all 8)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Actrt35
Arpm11
actin related protein M11, 5 82.02(n)1
79.4(a)1
  3 (14.27 cM)5
766521  NM_029690.21  NP_083966.11 
 305970735 
lizard
(Anolis carolinensis)
Reptilia ACTRT36
Uncharacterized protein
58(a)
1 ↔ 1
3(8001296-8005919)


ENSEMBL Gene Tree for ACTRT3 (if available)
TreeFam Gene Tree for ACTRT3 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for ACTRT3 gene
ACTG22  ACTA22  ACTRT22  ACTR1A2  ACTB2  ACTC12  ACTRT12  ACTG12  
ACTL7A2  ACTBL22  ACTL7B2  ACTR1B2  ACTA12  
18/26 SIMAP similar genes for ACTRT3 using alignment to 1 protein entry:     ACTT3_HUMAN(see all similar genes):
ACTC1    ACTG2    ACTG1    ACTA2    ACTB    PS1TP5BP1
ACTBL2    ACTRT1    POTEE    POTEF    POTEI    POTEJ
POTEKP    POTEM    ACTRT2    ACTR1A    ACTR1B    ACTL9

ACTRT3 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/132 SNPs in ACTRT3 are shown (see all 132)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 3 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1129931361,2
C--169484971(+) GGGAAA/GTATAA 1 -- ut310--------
rs1415229601,2
--169484996(+) AGTTAC/TAGAAG 1 -- ut310--------
rs168543561,2
C,F,H--169485091(+) CATTAT/CAGAAA 1 -- ut31 ese38Minor allele frequency- C:0.08NA EA NS WA 536
rs1812510811,2
--169485144(+) CTTCTC/GCCAGA 1 -- ut310--------
rs11348401,2
C--169485174(-) TGTGAC/AAGAAA 1 -- ut31 ese33Minor allele frequency- A:0.00MN NA 188
rs1508901321,2
C,F--169485261(+) TTCTTT/CAAATT 2 /K /E mis11Minor allele frequency- C:0.00NA 4544
rs1396788861,2
C--169485326(+) CTCCCA/GTCCAC 2 T M mis11Minor allele frequency- G:0.00NA 4548
rs1123348541,2
C,F--169485336(+) CACTGA/GTATTT 2 P S mis12Minor allele frequency- G:0.01NA EU 5869
rs1418422751,2
C,F--169485353(+) CTGGAG/AGAGCT 2 /P /L mis12Minor allele frequency- A:0.00NA EU 5867
rs2000575561,2
--169485383(+) TGGCAA/GGAGCC 2 P L mis10--------

HapMap Linkage Disequilibrium report for ACTRT3 (169484709 - 169487683 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for ACTRT3: --
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ACTRT3 for disorders           About MalaCards
OMIM gene information: 608534    OMIM disorders: --


ACTRT3 for disorders           About GeneDecksing


Export disorders for ACTRT3 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for ACTRT3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ACTRT3)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Identification of two cDNAs for human actin-related proteins (Arps) that have remarkable similarity to conventional actin. (PubMed id 11750065)1, 2, 3 Harata M.... Hatta S. (2001)
  2. Nuclear localization of profilin III-ArpM1 complex in mouse spermiogenesis. (PubMed id 18692047)1, 3 Hara Y....Baba T. (2008)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
  5. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (2006)
  6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 84517 HGNC: 24022 AceView: ARPM1 Ensembl:ENSG00000184378 euGenes: HUgn84517
ECgene: ACTRT3 H-InvDB: ACTRT3

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for ACTRT3 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for ACTRT3 gene:
Search GeneIP for patents involving ACTRT3

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
 Novus Tissue Slides
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 Antibodies for ACTRT3
 See all of Abcam's Antibodies, Kits and Proteins for ACTRT3
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 Browse ProSpec Recombinant Proteins




 Browse Proteins at Cloud-Clone Corp.
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 Search LifeMap BioReagents cell lines for ACTRT3
 Gene Synthesis
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 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACTRT3
 SwitchGear 3'UTR luciferase reporter plasmids for ACTRT3
 Browse SwitchGear Promoter luciferase reporter plasmids for ACTRT3
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 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACTRT3
 inGenious Targeting Laboratory - Custom generated mouse model solutions for ACTRT3
 inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ACTRT3
Customized:
 lentivirus for stable overexpression of ACTRT3
 lentivirus expression plasmids for stable overexpression of ACTRT3
 adenovirus for overexpression of ACTRT3
 LSBio Antibodies in human, mouse, rat for ACTRT3
Customized transgenic rodents for:
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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Category
(GIFtS: 73)
transforming growth factor, beta 1
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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