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ACTRT3 Gene

protein-coding   GIFtS: 38
GCID: GC03M169497

Actin-Related Protein T3

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Actin-Related Protein T31 2
ARPM12 3 5
Actin Related Protein M11 2
Actin-Related Protein M12 3
ARP-T32 3

External Ids:    HGNC: 240221   Entrez Gene: 845172   Ensembl: ENSG000001843787   OMIM: 6085345   UniProtKB: Q9BYD93   

Export aliases for ACTRT3 gene to outside databases

Previous GC identifers: GC03M169485 GC03M169487 GC03M169492


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ACTRT3 Gene:
ACTRT3 (actin-related protein T3) is a protein-coding gene. An important paralog of this gene is ACTG2.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_005612.17  
Regulatory elements:
   Search for regulatory transcription factor binding sites for ACTRT3
         Other transcription factors

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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ACTRT3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q26.2   Ensembl cytogenetic band:  3q26.2   HGNC cytogenetic band: 3q26.2

ACTRT3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ACTRT3 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M169497:  view genomic region     (about GC identifiers)

Start:
169,484,709 bp from pter      End:
169,487,683 bp from pter
Size:
2,975 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ACTT3_HUMAN, Q9BYD9 (See protein sequence)
Recommended Name: Actin-related protein T3  
Size: 372 amino acids; 41008 Da
Subunit: Interacts with PFN3 (By similarity)
Secondary accessions: Q96IS0 Q96NJ0

Explore the universe of human proteins at neXtProt for ACTRT3: NX_Q9BYD9

Explore proteomics data for ACTRT3 at MOPED


See ACTRT3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_115876.3  
ENSEMBL proteins: 
 ENSP00000333037  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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2 InterPro protein domains:
 IPR020902 Actin/actin-like_CS
 IPR004000 Actin-related

Graphical View of Domain Structure for InterPro Entry Q9BYD9

ProtoNet protein and cluster: Q9BYD9

1 Blocks protein domain: IPB004000 Actin/actin-like

UniProtKB/Swiss-Prot: ACTT3_HUMAN, Q9BYD9
Similarity: Belongs to the actin family


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(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding ----
     
Find genes that share ontologies with ACTRT3           About GenesLikeMe


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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
ACTT3_HUMAN, Q9BYD9: Cytoplasm, cytoskeleton (By similarity). Cytoplasm (By similarity). Nucleus (By similarity)

Gene Ontology (GO): 3 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001673male germ cell nucleus IEA--
GO:0005737cytoplasm IEA--
GO:0005856cytoskeleton IEA--

Find genes that share ontologies with ACTRT3           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ACTRT3
Interactions:

    Search GeneGlobe Interaction Network for ACTRT3

STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

Selected Interacting proteins for ACTRT3 (Q9BYD93 ENSP000003330374) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
InteractantInteraction Details
GeneCardExternal ID(s)
PFN3P606733, ENSP000003513794I2D: score=1 STRING: ENSP00000351379
SCAPERENSP000003269244STRING: ENSP00000326924
VCPENSP000003517774STRING: ENSP00000351777
VCPIP1ENSP000003090314STRING: ENSP00000309031
FAM118BENSP000003533214STRING: ENSP00000353321
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
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  Browse compounds at ApexBio 

Browse Tocris compounds for ACTRT3 (ACTT3)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for ACTRT3 gene: 
NM_032487.4  

Unigene Cluster for ACTRT3:

Actin-related protein T3
Hs.135411  [show with all ESTs]
Unigene Representative Sequence: NM_032487
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000330368(uc003ffs.2)
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Additional mRNA sequence: 

AB049117.1 AK055346.1 BC007289.1 

1 DOTS entry:

DT.40133096 

Selected AceView cDNA sequences (see all 27):

AK055346 AB049117 NM_032487 AA948283 AA373381 BE552203 BC007289 AI097065 
BX374164 AW467143 AI290635 BI765774 AI655508 AI811210 AA402182 BM559450 
BX329291 BG178280 BG037097 AI655489 BF980350 BE292981 AI825441 BU927731 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ACTRT3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
ACTRT3 Expression
About this image

ACTRT3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

ACTRT3 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.135411

UniProtKB/Swiss-Prot: ACTT3_HUMAN, Q9BYD9
Tissue specificity: Ubiquitously expressed

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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for ACTRT3 gene from Selected species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Actrt31 , 5 actin related protein M15
actin related protein T31
82.02(n)1
79.4(a)1
  3 (14.27 cM)5
766521  NM_029690.21  NP_083966.11 
 305970735 
lizard
(Anolis carolinensis)
Reptilia ACTRT36
actin-related protein T3
58(a)
1 ↔ 1
3(8001296-8005919)
fruit fly
(Drosophila melanogaster)
Insecta Arp53D6
Actin-related protein 53D
44(a)
1 → many
2R(12661811-12663179)


ENSEMBL Gene Tree for ACTRT3 (if available)
TreeFam Gene Tree for ACTRT3 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for ACTRT3 gene
ACTG22  ACTA22  ACTRT22  ACTR1A2  ACTB2  ACTC12  ACTRT12  ACTG12  
ACTBL22  ACTR1B2  ACTA12  
Selected SIMAP similar genes for ACTRT3 using alignment to 1 protein entry:     ACTT3_HUMAN(see all similar genes):
ACTC1    ACTG2    ACTG1    ACTA2    ACTB    PS1TP5BP1
ACTBL2    ACTRT1    POTEE    POTEF    POTEI    POTEJ
POTEKP    POTEM    ACTRT2    ACTR1A    ACTR1B    ACTL9

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(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for ACTRT3 (see all 132)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 3 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1129931361,2
C--169484971(+) GGGAAA/GTATAA 1 -- ut310--------
rs1415229601,2
--169484996(+) AGTTAC/TAGAAG 1 -- ut310--------
rs168543561,2
C,F,H--169485091(+) CATTAT/CAGAAA 1 -- ut31 ese38Minor allele frequency- C:0.08NA EA NS WA 536
rs1812510811,2
--169485144(+) CTTCTC/GCCAGA 1 -- ut310--------
rs11348401,2
C--169485174(-) TGTGAC/AAGAAA 1 -- ut31 ese33Minor allele frequency- A:0.00MN NA 188
rs1508901321,2
C,F--169485261(+) TTCTTT/CAAATT 2 /K /E mis11Minor allele frequency- C:0.00NA 4544
rs1396788861,2
C--169485326(+) CTCCCA/GTCCAC 2 T M mis11Minor allele frequency- G:0.00NA 4548
rs1123348541,2
C,F--169485336(+) CACTGA/GTATTT 2 P S mis12Minor allele frequency- G:0.01NA EU 5869
rs1418422751,2
C,F--169485353(+) CTGGAG/AGAGCT 2 /P /L mis12Minor allele frequency- A:0.00NA EU 5867
rs2000575561,2
--169485383(+) TGGCAA/GGAGCC 2 P L mis10--------

HapMap Linkage Disequilibrium report for ACTRT3 (169484709 - 169487683 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for ACTRT3: --
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing ACTRT3
DNA2.0 Custom Variant and Variant Library Synthesis for ACTRT3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 608534    OMIM disorders: --


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Export disorders for ACTRT3 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for ACTRT3 gene integrated from 10 sources:
(articles sorted by number of sources associating them with ACTRT3)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Identification of two cDNAs for human actin-related proteins (Arps) that have remarkable similarity to conventional actin. (PubMed id 11750065)1, 2, 3 Harata M.... Hatta S. (Biochim. Biophys. Acta 2001)
  2. Nuclear localization of profilin III-ArpM1 complex in mouse spermiogenesis. (PubMed id 18692047)1, 3 Hara Y....Baba T. (FEBS Lett. 2008)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  5. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (Nature 2006)
  6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 84517 HGNC: 24022 AceView: ARPM1 Ensembl:ENSG00000184378 euGenes: HUgn84517
ECgene: ACTRT3 H-InvDB: ACTRT3

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for ACTRT3 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for ACTRT3 gene:
Search GeneIP for patents involving ACTRT3

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 See all of Abcam's Antibodies, Kits and Proteins for ACTRT3
 Custom Antibody / Protein Production Service
 Bulk Purchasing
 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Browse ProSpec Recombinant Proteins
 Browse Proteins at Cloud-Clone Corp.
 Browse Antibodies at Cloud-Clone Corp.
 Browse ELISAs at Cloud-Clone Corp.
 Browse CLIAs at Cloud-Clone Corp.



 Browse ESI BIO Cell Lines and PureStem Progenitors for ACTRT3
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACTRT3
 SwitchGear 3'UTR luciferase reporter plasmids for ACTRT3
 Browse SwitchGear Promoter luciferase reporter plasmids for ACTRT3
 Search ThermoFisher Antibodies for ACTRT3
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACTRT3
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ACTRT3
 inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ACTRT3
 LSBio Antibodies in human, mouse, rat for ACTRT3
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
 Browse compounds at ApexBio
 Addgene plasmids for ACTRT3
  Search eBioscience for proteins for ACTRT3
  Search eBioscience for elisas for ACTRT3
  eBioscience FlowRNA Probe Sets
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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