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Aliases for ACTRT2 Gene

Aliases for ACTRT2 Gene

  • Actin-Related Protein T2 2 3
  • ARPM2 3 4 6
  • Actin-Related Protein M2 3 4
  • Arp-T2 3 4
  • ARPT2 3 6
  • Actin-Related Protein HArpM2 3
  • HARPM2 3

External Ids for ACTRT2 Gene

Summaries for ACTRT2 Gene

Entrez Gene Summary for ACTRT2 Gene

  • The protein encoded by this intronless gene belongs to the actin family. Studies have shown that this protein may be involved in cytoskeletal organization similar to other cytoplasmic actin-related protein (ARP) subfamily members. Antibody raised against the human protein has been used to detect the protein by immunoblotting and immunofluorescence microscopy, demonstrating its specific synthesis in the testis, late in spermatid differentiation, and its localization in the calyx. [provided by RefSeq, Jul 2008]

GeneCards Summary for ACTRT2 Gene

ACTRT2 (Actin-Related Protein T2) is a Protein Coding gene. An important paralog of this gene is ACTB.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACTRT2 Gene

Genomics for ACTRT2 Gene

Genomic Location for ACTRT2 Gene

Start:
3,021,482 bp from pter
End:
3,022,903 bp from pter
Size:
1,422 bases
Orientation:
Plus strand

Genomic View for ACTRT2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ACTRT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACTRT2 Gene

Regulatory Elements for ACTRT2 Gene

Proteins for ACTRT2 Gene

  • Protein details for ACTRT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TDY3-ACTT2_HUMAN
    Recommended name:
    Actin-related protein T2
    Protein Accession:
    Q8TDY3
    Secondary Accessions:
    • B1AN52
    • Q8NHS6
    • Q8TDG1

    Protein attributes for ACTRT2 Gene

    Size:
    377 amino acids
    Molecular mass:
    41702 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ACTRT2 Gene

Proteomics data for ACTRT2 Gene at MOPED

Post-translational modifications for ACTRT2 Gene

No Post-translational modifications

Other Protein References for ACTRT2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ACTRT2 Gene

Domains for ACTRT2 Gene

Protein Domains for ACTRT2 Gene

UniProtKB/Swiss-Prot:

ACTT2_HUMAN
Family:
  • Belongs to the actin family.:
    • Q8TDY3
genes like me logo Genes that share domains with ACTRT2: view

No data available for Gene Families for ACTRT2 Gene

Function for ACTRT2 Gene

Phenotypes for ACTRT2 Gene

genes like me logo Genes that share phenotypes with ACTRT2: view

miRNA for ACTRT2 Gene

miRTarBase miRNAs that target ACTRT2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for ACTRT2 Gene

Localization for ACTRT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACTRT2 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ACTRT2 Gene COMPARTMENTS Subcellular localization image for ACTRT2 gene
Compartment Confidence
cytosol 3
cytoskeleton 2
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ACTRT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with ACTRT2: view

Pathways for ACTRT2 Gene

SuperPathways for ACTRT2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ACTRT2 Gene

None

No data available for Pathways by source for ACTRT2 Gene

Transcripts for ACTRT2 Gene

mRNA/cDNA for ACTRT2 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(29) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ACTRT2 Gene

Actin-related protein T2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ACTRT2 Gene

No ASD Table

Relevant External Links for ACTRT2 Gene

GeneLoc Exon Structure for
ACTRT2
ECgene alternative splicing isoforms for
ACTRT2

Expression for ACTRT2 Gene

mRNA expression in normal human tissues for ACTRT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ACTRT2 Gene

This gene is overexpressed in Testis (52.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ACTRT2 Gene

SOURCE GeneReport for Unigene cluster for ACTRT2 Gene Hs.236635

genes like me logo Genes that share expressions with ACTRT2: view

Orthologs for ACTRT2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ACTRT2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ACTRT2 36
  • 99.29 (n)
  • 98.94 (a)
ACTRT2 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ACTRT2 36
  • 83.91 (n)
  • 84.08 (a)
ACTRT2 37
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ACTRT2 36
  • 84.97 (n)
  • 85.15 (a)
ACTRT2 37
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Actrt2 36
  • 79.49 (n)
  • 80.64 (a)
Actrt2 16
Actrt2 37
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 76 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 65 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Actrt2 36
  • 78.87 (n)
  • 81.17 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 53 (a)
OneToMany
ACTRT2 36
  • 62.78 (n)
  • 53.58 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 52 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia actb 36
  • 54.84 (n)
  • 47.47 (a)
fruit fly
(Drosophila melanogaster)
Insecta Arp53D 37
  • 44 (a)
OneToMany
Species with no ortholog for ACTRT2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ACTRT2 Gene

ENSEMBL:
Gene Tree for ACTRT2 (if available)
TreeFam:
Gene Tree for ACTRT2 (if available)

Paralogs for ACTRT2 Gene

Paralogs for ACTRT2 Gene

genes like me logo Genes that share paralogs with ACTRT2: view

Variants for ACTRT2 Gene

Sequence variations from dbSNP and Humsavar for ACTRT2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs3795262 -- 3,022,133(+) GCCTC(A/G/T)GCCTG synonymous-codon, reference
rs3795263 - 3,022,425(+) CCGAC(A/G)GGAAC missense, reference
rs4013154 -- 3,021,844(-) CTTCT(-/TCT)GGTTG cds-indel
rs4576609 -- 3,021,701(+) CCGCA(C/T)GCTTT reference, synonymous-codon
rs10492936 -- 3,020,306(+) TATGC(A/G)TCTGT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ACTRT2 Gene

Variant ID Type Subtype PubMed ID
nsv870655 CNV Loss 21882294
nsv428399 CNV Gain 18775914
nsv870889 CNV Loss 21882294
dgv87n71 CNV Loss 21882294
nsv871683 CNV Loss 21882294
dgv89n71 CNV Loss 21882294
nsv871581 CNV Loss 21882294
nsv470686 CNV Loss 18288195
dgv90n71 CNV Loss 21882294
nsv829759 CNV Loss 17160897
dgv91n71 CNV Loss 21882294

Relevant External Links for ACTRT2 Gene

HapMap Linkage Disequilibrium report
ACTRT2

Disorders for ACTRT2 Gene

No disorders were found for ACTRT2 Gene.

No data available for UniProtKB/Swiss-Prot for ACTRT2 Gene

Publications for ACTRT2 Gene

  1. Novel actin-related proteins Arp-T1 and Arp-T2 as components of the cytoskeletal calyx of the mammalian sperm head. (PMID: 12243744) Heid H.W. … Franke W.W. (Exp. Cell Res. 2002) 2 3 4 23
  2. Identification of two cDNAs for human actin-related proteins (Arps) that have remarkable similarity to conventional actin. (PMID: 11750065) Harata M. … Hatta S. (Biochim. Biophys. Acta 2001) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 4

Products for ACTRT2 Gene

Sources for ACTRT2 Gene

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