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Aliases for ACTRT2 Gene

Aliases for ACTRT2 Gene

  • Actin Related Protein T2 2 3 5
  • Actin-Related Protein M2 3 4
  • Arp-T2 3 4
  • ARPM2 3 4
  • Actin-Related Protein HArpM2 3
  • Actin-Related Protein T2 3
  • HARPM2 3
  • ARPT2 3

External Ids for ACTRT2 Gene

Previous GeneCards Identifiers for ACTRT2 Gene

  • GC01P002962
  • GC01P002233

Summaries for ACTRT2 Gene

Entrez Gene Summary for ACTRT2 Gene

  • The protein encoded by this intronless gene belongs to the actin family. Studies have shown that this protein may be involved in cytoskeletal organization similar to other cytoplasmic actin-related protein (ARP) subfamily members. Antibody raised against the human protein has been used to detect the protein by immunoblotting and immunofluorescence microscopy, demonstrating its specific synthesis in the testis, late in spermatid differentiation, and its localization in the calyx. [provided by RefSeq, Jul 2008]

GeneCards Summary for ACTRT2 Gene

ACTRT2 (Actin Related Protein T2) is a Protein Coding gene. An important paralog of this gene is ACTRT1.

Additional gene information for ACTRT2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACTRT2 Gene

Genomics for ACTRT2 Gene

Regulatory Elements for ACTRT2 Gene

Enhancers for ACTRT2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H002640 1.7 FANTOM5 Ensembl ENCODE 14.7 -378.9 -378948 3.2 ATF1 ARID4B SIN3A DMAP1 GLIS2 ZNF143 ZNF207 ATF7 RUNX3 SP3 MMEL1 ACTRT2 FAM213B MORN1 PANK4 GC01M002636 GC01P002648
GH01H003274 1.8 VISTA dbSUPER 11.8 +253.0 252959 0.8 ACTRT2 LINC00982 PRDM16 GC01P003272 PIR57396 PIR53217
GH01H003065 1.5 FANTOM5 ENCODE dbSUPER 12.2 +49.0 49021 9.4 ZSCAN4 RAD21 RARA GLIS2 ZNF143 THAP11 EGR2 ZNF362 ZEB2 REST MORN1 FAAP20 TP73-AS1 ACTRT2 LOC100129534 ENSG00000234396 PRDM16 LOC100420339 PIR58969
GH01H003420 1.2 VISTA ENCODE 12.1 +401.4 401420 4.9 MLX ZFP64 ARID4B DMAP1 ZNF2 SLC30A9 ZNF143 SP5 ZHX2 MXD4 TP73-AS1 ACTRT2 WRAP73 DFFB ENSG00000272153 GC01M003410 ARHGEF16
GH01H003284 0.9 ENCODE dbSUPER 11.7 +263.5 263546 1.7 RING1 CTCF REST ZNF2 RAD21 GLIS2 MBD1 PATZ1 ZNF341 ZNF143 MORN1 TP73-AS1 LOC100129534 ACTRT2 GC01M003273 GC01P003290
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ACTRT2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ACTRT2 Gene

Genomic Locations for ACTRT2 Gene
1,422 bases
Plus strand

Genomic View for ACTRT2 Gene

Genes around ACTRT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACTRT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACTRT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACTRT2 Gene

Proteins for ACTRT2 Gene

  • Protein details for ACTRT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Actin-related protein T2
    Protein Accession:
    Secondary Accessions:
    • B1AN52
    • Q8NHS6
    • Q8TDG1

    Protein attributes for ACTRT2 Gene

    377 amino acids
    Molecular mass:
    41702 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ACTRT2 Gene

Post-translational modifications for ACTRT2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ACTRT2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ACTRT2 Gene

Domains & Families for ACTRT2 Gene

Gene Families for ACTRT2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ACTRT2 Gene

Suggested Antigen Peptide Sequences for ACTRT2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the actin family.
  • Belongs to the actin family.
genes like me logo Genes that share domains with ACTRT2: view

Function for ACTRT2 Gene

Phenotypes From GWAS Catalog for ACTRT2 Gene

genes like me logo Genes that share phenotypes with ACTRT2: view

Animal Model Products

CRISPR Products

miRNA for ACTRT2 Gene

miRTarBase miRNAs that target ACTRT2

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ACTRT2 Gene

Localization for ACTRT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACTRT2 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ACTRT2 gene
Compartment Confidence
cytoskeleton 3
cytosol 3
plasma membrane 1
mitochondrion 1
peroxisome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ACTRT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with ACTRT2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ACTRT2 Gene

Pathways & Interactions for ACTRT2 Gene

SuperPathways for ACTRT2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ACTRT2 Gene


No data available for Pathways by source and SIGNOR curated interactions for ACTRT2 Gene

Drugs & Compounds for ACTRT2 Gene

No Compound Related Data Available

Transcripts for ACTRT2 Gene

mRNA/cDNA for ACTRT2 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(29) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ACTRT2 Gene

Actin-related protein T2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ACTRT2 Gene

No ASD Table

Relevant External Links for ACTRT2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ACTRT2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ACTRT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ACTRT2 Gene

This gene is overexpressed in Testis (x52.6).

Protein differential expression in normal tissues from HIPED for ACTRT2 Gene

This gene is overexpressed in Ovary (39.4) and Testis (29.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ACTRT2 Gene

Protein tissue co-expression partners for ACTRT2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ACTRT2 Gene:


SOURCE GeneReport for Unigene cluster for ACTRT2 Gene:

genes like me logo Genes that share expression patterns with ACTRT2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ACTRT2 Gene

Orthologs for ACTRT2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ACTRT2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ACTRT2 33 34
  • 99.29 (n)
(Canis familiaris)
Mammalia ACTRT2 34 33
  • 84.97 (n)
(Bos Taurus)
Mammalia ACTRT2 33 34
  • 83.91 (n)
(Mus musculus)
Mammalia Actrt2 16 34 33
  • 79.49 (n)
(Rattus norvegicus)
Mammalia Actrt2 33
  • 78.87 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 65 (a)
(Gallus gallus)
Aves ACTRT2 33
  • 62.78 (n)
-- 34
  • 53 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 52 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia actb 33
  • 54.84 (n)
fruit fly
(Drosophila melanogaster)
Insecta Arp53D 34
  • 44 (a)
Species where no ortholog for ACTRT2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ACTRT2 Gene

Gene Tree for ACTRT2 (if available)
Gene Tree for ACTRT2 (if available)

Paralogs for ACTRT2 Gene

Paralogs for ACTRT2 Gene

genes like me logo Genes that share paralogs with ACTRT2: view

Variants for ACTRT2 Gene

Sequence variations from dbSNP and Humsavar for ACTRT2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000415473 -- 3,022,307(+) TGCCA(A/G)CTGGA reference, synonymous-codon
rs1000783590 -- 3,019,639(+) CACCT(C/T)GCAGC upstream-variant-2KB
rs1001000664 -- 3,021,108(+) GGGAA(A/T)CACTA upstream-variant-2KB
rs1002720697 -- 3,023,286(+) CTGCC(A/G)CTCTC downstream-variant-500B
rs1002770605 -- 3,021,579(+) TTGAG(A/T)CACCC utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for ACTRT2 Gene

Variant ID Type Subtype PubMed ID
nsv951958 CNV deletion 24416366
nsv829759 CNV loss 17160897
nsv545098 CNV loss 21841781
nsv470686 CNV loss 18288195
nsv428399 CNV gain 18775914
nsv1013792 CNV gain 25217958
esv3585037 CNV gain 21293372
esv3585036 CNV gain 21293372
esv3583359 CNV gain 25503493
dgv11n100 CNV gain 25217958

Variation tolerance for ACTRT2 Gene

Residual Variation Intolerance Score: 48.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.62; 89.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ACTRT2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACTRT2 Gene

Disorders for ACTRT2 Gene

Relevant External Links for ACTRT2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ACTRT2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ACTRT2 Gene

Publications for ACTRT2 Gene

  1. Novel actin-related proteins Arp-T1 and Arp-T2 as components of the cytoskeletal calyx of the mammalian sperm head. (PMID: 12243744) Heid H … Franke W (Experimental cell research 2002) 2 3 4 22 60
  2. Identification of two cDNAs for human actin-related proteins (Arps) that have remarkable similarity to conventional actin. (PMID: 11750065) Harata M … Hatta S (Biochimica et biophysica acta 2001) 2 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L … Andersson-Svahn H (Molecular & cellular proteomics : MCP 2008) 3 60
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 4 60

Products for ACTRT2 Gene

Sources for ACTRT2 Gene

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