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Aliases for ACTRT1 Gene

Aliases for ACTRT1 Gene

  • Actin-Related Protein T1 2 3
  • ARPT1 3 4 6
  • ARP-T1 4
  • ARIP1 3
  • HSD27 3
  • AIP1 3

External Ids for ACTRT1 Gene

Previous GeneCards Identifiers for ACTRT1 Gene

  • GC0XM124030
  • GC0XM125129
  • GC0XM125890
  • GC0XM126910
  • GC0XM127012
  • GC0XM127184
  • GC0XM116588

Summaries for ACTRT1 Gene

Entrez Gene Summary for ACTRT1 Gene

  • This gene encodes a protein related to the cytoskeletal protein beta-actin. This protein is a major component of the calyx in the perinuclear theca of mammalian sperm heads, and it therefore likely functions in spermatid formation. This gene is intronless and is similar to a related gene located on chromosome 1. A related pseudogene has also been identified approximately 75 kb downstream of this gene on chromosome X. [provided by RefSeq, May 2010]

GeneCards Summary for ACTRT1 Gene

ACTRT1 (Actin-Related Protein T1) is a Protein Coding gene. Among its related pathways are PAK Pathway and Phospholipase-C Pathway. An important paralog of this gene is ACTB.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACTRT1 Gene

Genomics for ACTRT1 Gene

Regulatory Elements for ACTRT1 Gene

Genomic Location for ACTRT1 Gene

128,050,962 bp from pter
128,052,403 bp from pter
1,442 bases
Minus strand

Genomic View for ACTRT1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ACTRT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACTRT1 Gene

Proteins for ACTRT1 Gene

  • Protein details for ACTRT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Actin-related protein T1
    Protein Accession:
    Secondary Accessions:
    • Q6X7C1
    • Q96L10

    Protein attributes for ACTRT1 Gene

    376 amino acids
    Molecular mass:
    41696 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ACTRT1 Gene

Proteomics data for ACTRT1 Gene at MOPED

Post-translational modifications for ACTRT1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ACTRT1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for ACTRT1

No data available for DME Specific Peptides for ACTRT1 Gene

Domains for ACTRT1 Gene

Protein Domains for ACTRT1 Gene


Suggested Antigen Peptide Sequences for ACTRT1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the actin family.
  • Belongs to the actin family.
genes like me logo Genes that share domains with ACTRT1: view

No data available for Gene Families for ACTRT1 Gene

Function for ACTRT1 Gene

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ACTRT1

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ACTRT1 Gene

Localization for ACTRT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACTRT1 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

Jensen Localization Image for ACTRT1 Gene COMPARTMENTS Subcellular localization image for ACTRT1 gene
Compartment Confidence
cytosol 3
cytoskeleton 2
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ACTRT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with ACTRT1: view

Pathways for ACTRT1 Gene

genes like me logo Genes that share pathways with ACTRT1: view

Pathways by source for ACTRT1 Gene

Gene Ontology (GO) - Biological Process for ACTRT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002230 positive regulation of defense response to virus by host IMP 22020285
GO:0098779 activation of mitophagy in response to mitochondrial depolarization IMP 22020285
genes like me logo Genes that share ontologies with ACTRT1: view

Transcripts for ACTRT1 Gene

mRNA/cDNA for ACTRT1 Gene

(3) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ACTRT1 Gene

Actin-related protein T1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ACTRT1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ACTRT1 Gene

No ASD Table

Relevant External Links for ACTRT1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ACTRT1 Gene

mRNA expression in normal human tissues for ACTRT1 Gene

mRNA differential expression in normal tissues according to GTEx for ACTRT1 Gene

This gene is overexpressed in Testis (49.3).

Protein differential expression in normal tissues for ACTRT1 Gene

This gene is overexpressed in Testis (51.5), Spleen (9.3), and Prostate (8.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ACTRT1 Gene

SOURCE GeneReport for Unigene cluster for ACTRT1 Gene Hs.680125

genes like me logo Genes that share expressions with ACTRT1: view

Expression partners for ACTRT1 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ACTRT1 Gene

Orthologs for ACTRT1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ACTRT1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ACTRT1 35
  • 83.51 (n)
  • 80.59 (a)
  • 80 (a)
(Canis familiaris)
Mammalia ACTRT1 35
  • 84.49 (n)
  • 82.45 (a)
  • 82 (a)
(Mus musculus)
Mammalia Actrt1 35
  • 75.29 (n)
  • 71.2 (a)
Actrt1 16
Actrt1 36
  • 71 (a)
(Pan troglodytes)
Mammalia ACTRT1 35
  • 99.11 (n)
  • 98.67 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Actrt1 35
  • 74.31 (n)
  • 71.47 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 60 (a)
(Gallus gallus)
Aves -- 36
  • 51 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 49 (a)
fruit fly
(Drosophila melanogaster)
Insecta Arp53D 36
  • 43 (a)
Species with no ortholog for ACTRT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ACTRT1 Gene

Gene Tree for ACTRT1 (if available)
Gene Tree for ACTRT1 (if available)

Paralogs for ACTRT1 Gene

Paralogs for ACTRT1 Gene

(24) SIMAP similar genes for ACTRT1 Gene using alignment to 1 proteins: Pseudogenes for ACTRT1 Gene

genes like me logo Genes that share paralogs with ACTRT1: view

Variants for ACTRT1 Gene

Sequence variations from dbSNP and Humsavar for ACTRT1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs659820 -- 128,054,139(-) accag(C/T)ctgac upstream-variant-2KB
rs659853 -- 128,054,126(-) acatg(A/G)gaaac upstream-variant-2KB
rs687732 -- 128,052,502(-) CACCC(C/G)GCCCC upstream-variant-2KB
rs732182 -- 128,051,014(+) AAATG(C/G)CATCT utr-variant-3-prime
rs2077027 -- 128,050,580(+) CCCTA(C/T)TGCAC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for ACTRT1 Gene

Variant ID Type Subtype PubMed ID
esv2666298 CNV Deletion 23128226
dgv2473e1 CNV Complex 17122850

Relevant External Links for ACTRT1 Gene

HapMap Linkage Disequilibrium report
Locus Specific Mutation Databases (LSDB)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACTRT1 Gene

Disorders for ACTRT1 Gene

No disorders were found for ACTRT1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for ACTRT1 Gene

Publications for ACTRT1 Gene

  1. Novel actin-related proteins Arp-T1 and Arp-T2 as components of the cytoskeletal calyx of the mammalian sperm head. (PMID: 12243744) Heid H.W. … Franke W.W. (Exp. Cell Res. 2002) 2 3 4 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4
  4. Image-based genome-wide siRNA screen identifies selective autophagy factors. (PMID: 22020285) Orvedahl A. … Levine B. (Nature 2011) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for ACTRT1 Gene

Sources for ACTRT1 Gene

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