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ACTR8 Gene

protein-coding   GIFtS: 49
GCID: GC03M053901

ARP8 Actin-Related Protein 8 Homolog (Yeast)

(Previous names: ARP8 (actin-related protein 8, yeast) homolog)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ARP8 Actin-Related Protein 8 Homolog (Yeast)1 2     hArp82 3
INO80 Complex Subunit N1 2 3     ARP8 (Actin-Related Protein 8, Yeast) Homolog1
ARP82 3     Actin-Related Protein 82
INO80N2 3     

External Ids:    HGNC: 146721   Entrez Gene: 939732   Ensembl: ENSG000001138127   UniProtKB: Q9H9813   

Export aliases for ACTR8 gene to outside databases

Previous GC identifers: GC03U990227 GC03M053152 GC03M053755 GC03M053858 GC03M053877


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ACTR8 Gene:
ACTR8 (ARP8 actin-related protein 8 homolog (yeast)) is a protein-coding gene.

UniProtKB/Swiss-Prot: ARP8_HUMAN, Q9H981
Function: Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase
activity, and unable to polymerize
Function: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional
regulation, DNA reoplication and probably DNA repair. Required for the recruitment of INO80 (and probably the
INO80 complex) to sites of DNA damage. Strongly prefer nucleosomes and H3-H4 tetramers over H2A-H2B dimers,
suggesting it may act as a nucleosome recognition module within the complex




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ACTR8 gene promoter:
         HFH-3   Bach2   GATA-2   MEF-2A   FOXI1   PPAR-gamma1   HFH-1   aMEF-2   PPAR-gamma2   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidACTR8 promoter sequence
   Search Chromatin IP Primers for ACTR8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ACTR8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Ensembl cytogenetic band:  3p21.1   HGNC cytogenetic band: 3p21.31

ACTR8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ACTR8 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M053901:  view genomic region     (about GC identifiers)

Start:
53,901,093 bp from pter      End:
53,916,229 bp from pter
Size:
15,137 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ARP8_HUMAN, Q9H981 (See protein sequence)
Recommended Name: Actin-related protein 8  
Size: 624 amino acids; 70484 Da
Subunit: Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated
with the DBINO domain of INO80. Interacts with ACTR5; the interaction is observed in asynchronous (interphase)
cells but not in metaphase-arrested cells indicative for a possible dissociation of the INO80 complex in mitotic
cells. Exists as monomers and dimers, but the dimer is most probably the biologically relevant form required for
stable interactions with histones that exploits the twofold symmetry of the nucleosome core
Sequence caution: Sequence=BAB15402.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
1 PDB 3D structure from and Proteopedia for ACTR8:
4FO0 (3D)    
Secondary accessions: B3KSW7 Q8N566 Q9H663
Alternative splicing: 3 isoforms:  Q9H981-1   Q9H981-2   Q9H981-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ACTR8: NX_Q9H981

Explore proteomics data for ACTR8 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ACTR8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_075050.3  
    ENSEMBL proteins: 
     ENSP00000336842   ENSP00000419429   ENSP00000417230   ENSP00000417781   ENSP00000231909  

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    antibodies-online proteins for ACTR8 (9 products) 

     
    antibodies-online peptides for ACTR8

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    antibodies-online antibodies for ACTR8 (2 products) 

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    antibodies-online kits for ACTR8 (18 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    INO80: INO80 complex subunits

    2 InterPro protein domains:
     IPR027668 Arp8/plant_Arp9
     IPR004000 Actin-related

    Graphical View of Domain Structure for InterPro Entry Q9H981

    ProtoNet protein and cluster: Q9H981

    1 Blocks protein domain: IPB004000 Actin/actin-like

    UniProtKB/Swiss-Prot: ARP8_HUMAN, Q9H981
    Similarity: Belongs to the actin family. ARP8 subfamily


    Find genes that share domains with ACTR8           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ARP8_HUMAN, Q9H981
    Function: Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase
    activity, and unable to polymerize
    Function: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional
    regulation, DNA reoplication and probably DNA repair. Required for the recruitment of INO80 (and probably the
    INO80 complex) to sites of DNA damage. Strongly prefer nucleosomes and H3-H4 tetramers over H2A-H2B dimers,
    suggesting it may act as a nucleosome recognition module within the complex

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16230350
    GO:0005524ATP binding IEA--
         
    Find genes that share ontologies with ACTR8           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ACTR8:
     Increased cilium length after  

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ACTR8

    miRNA
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    miRTarBase miRNAs that target ACTR8:
    hsa-mir-124-3p (MIRT002578), hsa-mir-26b-5p (MIRT029896)

    Block miRNA regulation of human, mouse, rat ACTR8 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ACTR8 (see all 19):
    hsa-miR-520e hsa-miR-302d hsa-miR-607 hsa-miR-302e hsa-miR-512-3p hsa-miR-520a-3p hsa-miR-372 hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidACTR8 3' UTR sequence
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACTR8
    Addgene plasmids for ACTR8 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ARP8_HUMAN, Q9H981: Nucleus. Chromosome. Note=Specifically localizes to mitotic chromosomes
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA18026119
    GO:0031011Ino80 complex IDA18026119

    Find genes that share ontologies with ACTR8           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ACTR8
    Interactions:

        Search GeneGlobe Interaction Network for ACTR8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ACTR8 (Q9H9811, 3 ENSP000003368424) via UniProtKB, MINT, STRING, and/or I2D (see all 375)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4HP628053, ENSP000002893524I2D: score=2 STRING: ENSP00000289352
    HIST1H4FP628053, ENSP000003669744I2D: score=2 STRING: ENSP00000366974
    HIST1H4AP628053I2D: score=2 
    HIST1H4BP628053I2D: score=2 
    HIST1H4CP628053I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006281DNA repair IEA--
    GO:0006310DNA recombination IEA--
    GO:0006338chromatin remodeling IEA--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    Find genes that share ontologies with ACTR8           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ACTR8 (ARP8)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ACTR8 gene: 
    NM_022899.4  

    Unigene Cluster for ACTR8:

    ARP8 actin-related protein 8 homolog (yeast)
    Hs.412186  [show with all ESTs]
    Unigene Representative Sequence: NM_022899
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000335754(uc003dhb.3 uc003dhc.3 uc003dhd.3) ENST00000488802
    ENST00000482349 ENST00000486794 ENST00000495993 ENST00000498740 ENST00000231909

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    Selected qRT-PCR Assays for microRNAs that regulate ACTR8 (see all 19):
    hsa-miR-520e hsa-miR-302d hsa-miR-607 hsa-miR-302e hsa-miR-512-3p hsa-miR-520a-3p hsa-miR-372 hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidACTR8 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ACTR8
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ACTR8 (NM_022899)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ACTR8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACTR8
    Addgene plasmids for ACTR8 
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ACTR8
      QuantiTect SYBR Green Assays in human, mouse, rat ACTR8
      QuantiFast Probe-based Assays in human, mouse, rat ACTR8

    Additional mRNA sequence: 

    AK022996.1 AK026232.1 AK094507.1 

    7 DOTS entries:

    DT.311103  DT.100763889  DT.99952469  DT.91760477  DT.120891686  DT.120891692  DT.75120344 

    Selected AceView cDNA sequences (see all 158):

    AW967064 BX101744 AA721647 AA903925 BM749422 BX354685 AI653554 AA809485 
    AA844516 AI241787 AA732693 CA748581 BU070599 AI203628 BG574666 AI350843 
    BU069934 NM_022899 AK022996 AI208233 AA317304 R73542 BG433769 BU684210 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ACTR8    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c
    SP1:        -     -                                                                 -                                             
    SP2:                    -                                                           -                                             
    SP3:                                                                          -                                                   
    SP4:        -     -     -                                                                                                         
    SP5:                                                                                                                              


    ECgene alternative splicing isoforms for ACTR8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ACTR8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACAAATAAGT
    ACTR8 Expression
    About this image

    ACTR8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ACTR8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.412186
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ACTR8 gene from Selected species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Actr81 , 5 ARP8 actin-related protein 8 homolog (S. cerevisiae)5
    ARP8 actin-related protein 81
    89.1(n)1
    97.12(a)1
      14 (18.37 cM)5
    562491  NM_027493.31  NP_081769.21 
     299783375 
    chicken
    (Gallus gallus)
    Aves ACTR81 ARP8 actin-related protein 8 homolog (yeast) 79.05(n)
    90.51(a)
      415994  XM_414336.4  XP_414336.2 
    lizard
    (Anolis carolinensis)
    Reptilia ACTR86
    ARP8 actin-related protein 8 homolog (yeast)
    86(a)
    1 ↔ 1
    2(160570113-160587545)
    African clawed frog
    (Xenopus laevis)
    Amphibia actr8-A-prov2 ARP8 actin-related protein 8 homolog (yeast) 75.64(n)    BC047960.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.76702 Danio rerio mRNA similar to ARP8 actin-related protein more 74.6(n)    BC044364.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Arp81 Actin-related protein 8 46(n)
    35.7(a)
      32769  NM_133023.4  NP_573251.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ARP8(YOR141C)4
    ARP81
    Nuclear actin-related protein involved in chromatin more4
    ARP81
    46.09(n)1
    32.91(a)1
      15(592587-589942)4
    8543091, 4  NP_014784.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ARP91 ARP9 46.04(n)
    32.88(a)
      834370  NM_203147.1  NP_974876.1 
    rice
    (Oryza sativa)
    Liliopsida Os04g01776001 Os04g0177600 47.8(n)
    35.61(a)
      4335089  NM_001058705.1  NP_001052170.1 


    ENSEMBL Gene Tree for ACTR8 (if available)
    TreeFam Gene Tree for ACTR8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ACTR8 (see all 441)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs98759621,2
    C,F,A,H--53900682(+) TTTTTG/ATATTT 1 -- ds50012Minor allele frequency- A:0.40NA CSA 5
    rs580650231,2
    C--53900682(+) TTTTT-/ATA   
      TTTTTA
    GTAGA
    1 -- ds50010--------
    rs126384531,2
    C,H--53900690(+) TTTTTA/TGTAGA 1 -- ds50010--------
    rs1469807561,2
    C--53900797(+) GCCACC/GGCGCC 1 -- ds50010--------
    rs170535681,2
    C,F,H--53900829(+) TTTAAT/CGCAGA 1 -- ds500117Minor allele frequency- C:0.43NA EA NS WA CSA 994
    rs341678601,2
    C--53900862(+) AAATGT/-TTTTT 1 -- ds50012Minor allele frequency- -:0.25NA CSA 4
    rs1476531231,2
    --53900955(+) TGTGTA/GTATTT 1 -- ds50010--------
    rs170535691,2
    C,F,H--53901014(+) CGGATA/CAAAAA 1 -- ds500113Minor allele frequency- C:0.06NA NS EA CSA WA 1450
    rs1422495961,2
    --53901131(+) TCAGTC/TTTCAC 1 -- ut310--------
    rs1458041291,2
    --53901229(+) CAGTTA/GTAAGA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ACTR8 (53901093 - 53916229 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ACTR8:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv876804CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with ACTR8           About GenesLikeMe

    Human Genome Epidemiology (HuGE) Navigator: ACTR8 (1 document)

    Export disorders for ACTR8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ACTR8 gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with ACTR8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The actin-related protein hArp8 accumulates on the mitotic chromosomes and functions in chromosome alignment. (PubMed id 18163988)1, 2, 3 Aoyama N.... Harata M. (Exp. Cell Res. 2008)
    2. A mammalian chromatin remodeling complex with similarities to the yeast INO80 complex. (PubMed id 16230350)1, 2, 3 Jin J.... Conaway J.W. (J. Biol. Chem. 2005)
    3. Structure of Actin-related protein 8 and its contribution to nucleosome binding. (PubMed id 22977180)1, 2 Gerhold C.B.... Hopfner K.P. (Nucleic Acids Res. 2012)
    4. Subunit organization of the human INO80 chromatin remodeling complex: An evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling. (PubMed id 21303910)1, 2 Chen L.... Conaway R.C. (J. Biol. Chem. 2011)
    5. Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin-remodeling complex. (PubMed id 18922472)1, 2 Yao T.... Conaway J.W. (Mol. Cell 2008)
    6. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    9. Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error. (PubMed id 24144296)1 Cheng C.Y....Baird P.N. (Am. J. Hum. Genet. 2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 93973 HGNC: 14672 AceView: ACTR8 Ensembl:ENSG00000113812 euGenes: HUgn93973
    ECgene: ACTR8 H-InvDB: ACTR8

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ACTR8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ACTR8 gene:
    Search GeneIP for patents involving ACTR8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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