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Aliases for ACTR8 Gene

Aliases for ACTR8 Gene

  • ARP8 Actin-Related Protein 8 Homolog (Yeast) 2 3
  • INO80 Complex Subunit N 2 3 4
  • INO80N 3 4
  • HArp8 3 4
  • ARP8 3 4
  • ARP8 (Actin-Related Protein 8, Yeast) Homolog 2
  • Actin-Related Protein 8 3

External Ids for ACTR8 Gene

Previous GeneCards Identifiers for ACTR8 Gene

  • GC03U990227
  • GC03M053152
  • GC03M053755
  • GC03M053858
  • GC03M053877

Summaries for ACTR8 Gene

GeneCards Summary for ACTR8 Gene

ACTR8 (ARP8 Actin-Related Protein 8 Homolog (Yeast)) is a Protein Coding gene.

UniProtKB/Swiss-Prot for ACTR8 Gene

  • Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize

  • Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA reoplication and probably DNA repair. Required for the recruitment of INO80 (and probably the INO80 complex) to sites of DNA damage. Strongly prefer nucleosomes and H3-H4 tetramers over H2A-H2B dimers, suggesting it may act as a nucleosome recognition module within the complex

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACTR8 Gene

Genomics for ACTR8 Gene

Regulatory Elements for ACTR8 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ACTR8 Gene

Start:
53,865,016 bp from pter
End:
53,882,202 bp from pter
Size:
17,187 bases
Orientation:
Minus strand

Genomic View for ACTR8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ACTR8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACTR8 Gene

Proteins for ACTR8 Gene

  • Protein details for ACTR8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H981-ARP8_HUMAN
    Recommended name:
    Actin-related protein 8
    Protein Accession:
    Q9H981
    Secondary Accessions:
    • B3KSW7
    • Q8N566
    • Q9H663

    Protein attributes for ACTR8 Gene

    Size:
    624 amino acids
    Molecular mass:
    70484 Da
    Quaternary structure:
    • Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the DBINO domain of INO80. Interacts with ACTR5; the interaction is observed in asynchronous (interphase) cells but not in metaphase-arrested cells indicative for a possible dissociation of the INO80 complex in mitotic cells. Exists as monomers and dimers, but the dimer is most probably the biologically relevant form required for stable interactions with histones that exploits the twofold symmetry of the nucleosome core.
    SequenceCaution:
    • Sequence=BAB15402.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ACTR8 Gene

    Alternative splice isoforms for ACTR8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ACTR8 Gene

Proteomics data for ACTR8 Gene at MOPED

Post-translational modifications for ACTR8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ACTR8 Gene

No data available for DME Specific Peptides for ACTR8 Gene

Domains for ACTR8 Gene

Gene Families for ACTR8 Gene

HGNC:
  • INO80 :INO80 complex subunits

Protein Domains for ACTR8 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ACTR8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H981

UniProtKB/Swiss-Prot:

ARP8_HUMAN :
  • Q9H981
Family:
  • Belongs to the actin family. ARP8 subfamily.
genes like me logo Genes that share domains with ACTR8: view

Function for ACTR8 Gene

Molecular function for ACTR8 Gene

UniProtKB/Swiss-Prot Function: Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize
UniProtKB/Swiss-Prot Function: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA reoplication and probably DNA repair. Required for the recruitment of INO80 (and probably the INO80 complex) to sites of DNA damage. Strongly prefer nucleosomes and H3-H4 tetramers over H2A-H2B dimers, suggesting it may act as a nucleosome recognition module within the complex

Gene Ontology (GO) - Molecular Function for ACTR8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16230350
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with ACTR8: view

Phenotypes for ACTR8 Gene

GenomeRNAi human phenotypes for ACTR8:
genes like me logo Genes that share phenotypes with ACTR8: view

Animal Model Products

CRISPR Products

miRNA for ACTR8 Gene

miRTarBase miRNAs that target ACTR8

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ACTR8 Gene

Localization for ACTR8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACTR8 Gene

Nucleus. Chromosome. Note=Specifically localizes to mitotic chromosomes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ACTR8 Gene COMPARTMENTS Subcellular localization image for ACTR8 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ACTR8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 18026119
GO:0031011 Ino80 complex IDA 18026119
genes like me logo Genes that share ontologies with ACTR8: view

Pathways for ACTR8 Gene

SuperPathways for ACTR8 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ACTR8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IEA --
GO:0006310 DNA recombination IEA --
GO:0006338 chromatin remodeling IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ACTR8: view

No data available for Pathways by source for ACTR8 Gene

Transcripts for ACTR8 Gene

Unigene Clusters for ACTR8 Gene

ARP8 actin-related protein 8 homolog (yeast):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ACTR8

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ACTR8

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ACTR8 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c
SP1: - - -
SP2: - -
SP3: -
SP4: - - -
SP5:

Relevant External Links for ACTR8 Gene

GeneLoc Exon Structure for
ACTR8
ECgene alternative splicing isoforms for
ACTR8

Expression for ACTR8 Gene

mRNA expression in normal human tissues for ACTR8 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ACTR8 Gene

SOURCE GeneReport for Unigene cluster for ACTR8 Gene Hs.412186

genes like me logo Genes that share expressions with ACTR8: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ACTR8 Gene

Orthologs for ACTR8 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ACTR8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ACTR8 35
  • 99.41 (n)
  • 99.84 (a)
ACTR8 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ACTR8 35
  • 93.32 (n)
  • 98.24 (a)
ACTR8 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ACTR8 35
  • 92.79 (n)
  • 98.4 (a)
ACTR8 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Actr8 35
  • 89.1 (n)
  • 97.12 (a)
Actr8 16
Actr8 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ACTR8 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ACTR8 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Actr8 35
  • 88.62 (n)
  • 97.28 (a)
chicken
(Gallus gallus)
Aves ACTR8 35
  • 79.05 (n)
  • 90.51 (a)
ACTR8 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ACTR8 36
  • 86 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia actr8-A-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia actr8 35
  • 73.58 (n)
  • 81.85 (a)
Str.3965 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10425 35
zebrafish
(Danio rerio)
Actinopterygii actr8 35
  • 69.61 (n)
  • 74.44 (a)
actr8 36
  • 75 (a)
OneToOne
Dr.7670 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010671 35
  • 49.85 (n)
  • 41.42 (a)
fruit fly
(Drosophila melanogaster)
Insecta Arp8 35
  • 46 (n)
  • 35.7 (a)
Arp8 36
  • 31 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR135W 35
  • 45.44 (n)
  • 32.58 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARP8 35
  • 46.09 (n)
  • 32.91 (a)
ARP8 36
  • 18 (a)
OneToOne
ARP8 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E03213g 35
  • 44.99 (n)
  • 31.39 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons ARP9 35
  • 46.04 (n)
  • 32.88 (a)
rice
(Oryza sativa)
Liliopsida Os04g0177600 35
  • 47.8 (n)
  • 35.61 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06238 35
  • 46.73 (n)
  • 35.21 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes arp8 35
  • 43.35 (n)
  • 30.92 (a)
Species with no ortholog for ACTR8:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ACTR8 Gene

ENSEMBL:
Gene Tree for ACTR8 (if available)
TreeFam:
Gene Tree for ACTR8 (if available)

Paralogs for ACTR8 Gene

No data available for Paralogs for ACTR8 Gene

Variants for ACTR8 Gene

Sequence variations from dbSNP and Humsavar for ACTR8 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs744277 -- 53,876,091(-) TCTTT(C/T)CCCCC intron-variant
rs744381 -- 53,875,515(+) ACCAC(G/T)ATGAC intron-variant
rs768492 -- 53,878,387(+) CTTGT(A/C)CCATT synonymous-codon, reference
rs893367 -- 53,875,704(-) CCTGG(G/T)ATGTT intron-variant
rs1046677 -- 53,871,281(-) GAAGG(A/G)AAAGC reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for ACTR8 Gene

Variant ID Type Subtype PubMed ID
nsv876804 CNV Gain 21882294

Relevant External Links for ACTR8 Gene

HapMap Linkage Disequilibrium report
ACTR8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACTR8 Gene

Disorders for ACTR8 Gene

Relevant External Links for ACTR8

Human Genome Epidemiology (HuGE) Navigator
ACTR8
genes like me logo Genes that share disorders with ACTR8: view

No data available for UniProtKB/Swiss-Prot for ACTR8 Gene

Publications for ACTR8 Gene

  1. The actin-related protein hArp8 accumulates on the mitotic chromosomes and functions in chromosome alignment. (PMID: 18163988) Aoyama N. … Harata M. (Exp. Cell Res. 2008) 2 3 4
  2. A mammalian chromatin remodeling complex with similarities to the yeast INO80 complex. (PMID: 16230350) Jin J. … Conaway J.W. (J. Biol. Chem. 2005) 2 3 4
  3. Structure of Actin-related protein 8 and its contribution to nucleosome binding. (PMID: 22977180) Gerhold C.B. … Hopfner K.P. (Nucleic Acids Res. 2012) 3 4
  4. Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin-remodeling complex. (PMID: 18922472) Yao T. … Conaway J.W. (Mol. Cell 2008) 3 4
  5. Subunit organization of the human INO80 chromatin remodeling complex: An evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling. (PMID: 21303910) Chen L. … Conaway R.C. (J. Biol. Chem. 2011) 3 4

Products for ACTR8 Gene

Sources for ACTR8 Gene

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