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Aliases for ACTR8 Gene

Aliases for ACTR8 Gene

  • ARP8 Actin-Related Protein 8 Homolog 2 3
  • INO80 Complex Subunit N 2 3 4
  • INO80N 3 4
  • HArp8 3 4
  • ARP8 3 4
  • ARP8 (Actin-Related Protein 8, Yeast) Homolog 2
  • ARP8 Actin-Related Protein 8 Homolog (Yeast) 5

External Ids for ACTR8 Gene

Previous GeneCards Identifiers for ACTR8 Gene

  • GC03U990227
  • GC03M053152
  • GC03M053755
  • GC03M053858
  • GC03M053877

Summaries for ACTR8 Gene

GeneCards Summary for ACTR8 Gene

ACTR8 (ARP8 Actin-Related Protein 8 Homolog) is a Protein Coding gene. Among its related pathways are DNA Double-Strand Break Repair and Transcription-Coupled Nucleotide Excision Repair (TC-NER).

UniProtKB/Swiss-Prot for ACTR8 Gene

  • Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize.

  • Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA reoplication and probably DNA repair. Required for the recruitment of INO80 (and probably the INO80 complex) to sites of DNA damage. Strongly prefer nucleosomes and H3-H4 tetramers over H2A-H2B dimers, suggesting it may act as a nucleosome recognition module within the complex.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACTR8 Gene

Genomics for ACTR8 Gene

Regulatory Elements for ACTR8 Gene

Promoters for ACTR8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ACTR8 on UCSC Golden Path with GeneCards custom track

Genomic Location for ACTR8 Gene

Chromosome:
3
Start:
53,864,931 bp from pter
End:
53,882,202 bp from pter
Size:
17,272 bases
Orientation:
Minus strand

Genomic View for ACTR8 Gene

Genes around ACTR8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACTR8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACTR8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACTR8 Gene

Proteins for ACTR8 Gene

  • Protein details for ACTR8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H981-ARP8_HUMAN
    Recommended name:
    Actin-related protein 8
    Protein Accession:
    Q9H981
    Secondary Accessions:
    • B3KSW7
    • Q8N566
    • Q9H663

    Protein attributes for ACTR8 Gene

    Size:
    624 amino acids
    Molecular mass:
    70484 Da
    Quaternary structure:
    • Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the DBINO domain of INO80. Interacts with ACTR5; the interaction is observed in asynchronous (interphase) cells but not in metaphase-arrested cells indicative for a possible dissociation of the INO80 complex in mitotic cells. Exists as monomers and dimers, but the dimer is most probably the biologically relevant form required for stable interactions with histones that exploits the twofold symmetry of the nucleosome core.
    SequenceCaution:
    • Sequence=BAB15402.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ACTR8 Gene

    Alternative splice isoforms for ACTR8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ACTR8 Gene

Proteomics data for ACTR8 Gene at MOPED

Post-translational modifications for ACTR8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ACTR8 Gene

No data available for DME Specific Peptides for ACTR8 Gene

Domains & Families for ACTR8 Gene

Gene Families for ACTR8 Gene

Protein Domains for ACTR8 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ACTR8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H981

UniProtKB/Swiss-Prot:

ARP8_HUMAN :
  • Belongs to the actin family. ARP8 subfamily.
Family:
  • Belongs to the actin family. ARP8 subfamily.
genes like me logo Genes that share domains with ACTR8: view

Function for ACTR8 Gene

Molecular function for ACTR8 Gene

UniProtKB/Swiss-Prot Function:
Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize.
UniProtKB/Swiss-Prot Function:
Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA reoplication and probably DNA repair. Required for the recruitment of INO80 (and probably the INO80 complex) to sites of DNA damage. Strongly prefer nucleosomes and H3-H4 tetramers over H2A-H2B dimers, suggesting it may act as a nucleosome recognition module within the complex.
genes like me logo Genes that share phenotypes with ACTR8: view

Animal Models for ACTR8 Gene

MGI Knock Outs for ACTR8:

Animal Model Products

miRNA for ACTR8 Gene

miRTarBase miRNAs that target ACTR8

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ACTR8 Gene

Localization for ACTR8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACTR8 Gene

Nucleus. Chromosome. Note=Specifically localizes to mitotic chromosomes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ACTR8 Gene COMPARTMENTS Subcellular localization image for ACTR8 gene
Compartment Confidence
nucleus 5
cytoskeleton 4
cytosol 2
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for ACTR8 Gene

Pathways & Interactions for ACTR8 Gene

genes like me logo Genes that share pathways with ACTR8: view

Gene Ontology (GO) - Biological Process for ACTR8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0007067 mitotic nuclear division IEA --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with ACTR8: view

No data available for SIGNOR curated interactions for ACTR8 Gene

Drugs & Compounds for ACTR8 Gene

No Compound Related Data Available

Transcripts for ACTR8 Gene

Unigene Clusters for ACTR8 Gene

ARP8 actin-related protein 8 homolog (yeast):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ACTR8 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c
SP1: - - -
SP2: - -
SP3: -
SP4: - - -
SP5:

Relevant External Links for ACTR8 Gene

GeneLoc Exon Structure for
ACTR8
ECgene alternative splicing isoforms for
ACTR8

Expression for ACTR8 Gene

mRNA expression in normal human tissues for ACTR8 Gene

Protein differential expression in normal tissues from HIPED for ACTR8 Gene

This gene is overexpressed in Platelet (25.2), Placenta (12.9), Peripheral blood mononuclear cells (8.3), and Blymphocyte (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ACTR8 Gene



SOURCE GeneReport for Unigene cluster for ACTR8 Gene Hs.412186

genes like me logo Genes that share expression patterns with ACTR8: view

Protein tissue co-expression partners for ACTR8 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ACTR8 Gene

Orthologs for ACTR8 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ACTR8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ACTR8 36
  • 100 (a)
OneToOne
ACTR8 35
  • 99.41 (n)
  • 99.84 (a)
cow
(Bos Taurus)
Mammalia ACTR8 36
  • 98 (a)
OneToOne
ACTR8 35
  • 93.32 (n)
  • 98.24 (a)
dog
(Canis familiaris)
Mammalia ACTR8 35
  • 92.79 (n)
  • 98.4 (a)
ACTR8 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Actr8 36
  • 97 (a)
OneToOne
Actr8 35
  • 89.1 (n)
  • 97.12 (a)
Actr8 16
oppossum
(Monodelphis domestica)
Mammalia ACTR8 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ACTR8 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Actr8 35
  • 88.62 (n)
  • 97.28 (a)
chicken
(Gallus gallus)
Aves ACTR8 35
  • 79.05 (n)
  • 90.51 (a)
ACTR8 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ACTR8 36
  • 86 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia actr8-A-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia actr8 35
  • 73.58 (n)
  • 81.85 (a)
Str.3965 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10425 35
zebrafish
(Danio rerio)
Actinopterygii actr8 36
  • 75 (a)
OneToOne
actr8 35
  • 69.61 (n)
  • 74.44 (a)
Dr.7670 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010671 35
  • 49.85 (n)
  • 41.42 (a)
fruit fly
(Drosophila melanogaster)
Insecta Arp8 35
  • 46 (n)
  • 35.7 (a)
Arp8 36
  • 31 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR135W 35
  • 45.44 (n)
  • 32.58 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARP8 35
  • 46.09 (n)
  • 32.91 (a)
ARP8 36
  • 18 (a)
OneToOne
ARP8 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E03213g 35
  • 44.99 (n)
  • 31.39 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons ARP9 35
  • 46.04 (n)
  • 32.88 (a)
rice
(Oryza sativa)
Liliopsida Os04g0177600 35
  • 47.8 (n)
  • 35.61 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06238 35
  • 46.73 (n)
  • 35.21 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes arp8 35
  • 43.35 (n)
  • 30.92 (a)
Species with no ortholog for ACTR8:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ACTR8 Gene

ENSEMBL:
Gene Tree for ACTR8 (if available)
TreeFam:
Gene Tree for ACTR8 (if available)

Paralogs for ACTR8 Gene

No data available for Paralogs for ACTR8 Gene

Variants for ACTR8 Gene

Sequence variations from dbSNP and Humsavar for ACTR8 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs893367 -- 53,875,704(-) CCTGG(G/T)ATGTT intron-variant
rs3733079 -- 53,877,513(+) GAGTC(A/G)GTGTG intron-variant
rs3733080 -- 53,878,164(+) CACCA(C/T)CTTAT intron-variant
rs3733081 -- 53,878,314(+) GATAC(A/C)AATAG intron-variant
rs3733082 - 53,880,066(+) AAGTT(A/G)TTGAA nc-transcript-variant, reference, missense, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for ACTR8 Gene

Variant ID Type Subtype PubMed ID
nsv876804 CNV Gain 21882294

Variation tolerance for ACTR8 Gene

Residual Variation Intolerance Score: 15.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.42; 77.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ACTR8 Gene

HapMap Linkage Disequilibrium report
ACTR8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACTR8 Gene

Disorders for ACTR8 Gene

Relevant External Links for ACTR8

Human Genome Epidemiology (HuGE) Navigator
ACTR8
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ACTR8

No disorders were found for ACTR8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ACTR8 Gene

Publications for ACTR8 Gene

  1. The actin-related protein hArp8 accumulates on the mitotic chromosomes and functions in chromosome alignment. (PMID: 18163988) Aoyama N. … Harata M. (Exp. Cell Res. 2008) 2 3 4 67
  2. A mammalian chromatin remodeling complex with similarities to the yeast INO80 complex. (PMID: 16230350) Jin J. … Conaway J.W. (J. Biol. Chem. 2005) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. DNA binding properties of the actin-related protein Arp8 and its role in DNA repair. (PMID: 25299602) Osakabe A. … Harata M. (PLoS ONE 2014) 3

Products for ACTR8 Gene

Sources for ACTR8 Gene

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