Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ACTR8 Gene

protein-coding   GIFtS: 47
GCID: GC03M053901

ARP8 actin-related protein 8 homolog (yeast)

(Previous names: ARP8 (actin-related protein 8, yeast) homolog )
 Explore 3 diseases affiliated with
ACTR8 via our new
 Human Malady Compendium 
Biological research products
for ACTR8
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
ARP8 Actin-Related Protein 8 Homolog (Yeast)1 2     INO80 Complex Subunit N2 3
INO80N1 2 3     ARP8 (Actin-Related Protein 8, Yeast) Homolog1
ARP82 3     Actin-Related Protein 82
HArp81     

External Ids:    HGNC: 146721   Entrez Gene: 939732   Ensembl: ENSG000001138127   UniProtKB: Q9H9813   

Export aliases for ACTR8 gene to outside databases

Previous GC identifers: GC03U990227 GC03M053152 GC03M053755 GC03M053858 GC03M053877


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ARP8_HUMAN, Q9H981
Function: Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase
activity, and unable to polymerize
Function: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional
regulation, DNA reoplication and probably DNA repair. Required for the recruitment of INO80 (and probably the INO80
complex) to sites of DNA damage. Strongly prefer nucleosomes and H3-H4 tetramers over H2A-H2B dimers, suggesting it
may act as a nucleosome recognition module within the complex




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_022517.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ACTR8 gene promoter:
         HFH-3   Bach2   GATA-2   MEF-2A   FOXI1   PPAR-gamma1   HFH-1   aMEF-2   PPAR-gamma2   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidACTR8 promoter sequence
   Search SABiosciences Chromatin IP Primers for ACTR8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ACTR8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Ensembl cytogenetic band:  3p21.1   HGNC cytogenetic band: 3p21.31

ACTR8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ACTR8 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M053901:  view genomic region     (about GC identifiers)

Start:
53,901,093 bp from pter      End:
53,916,229 bp from pter
Size:
15,137 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ARP8_HUMAN, Q9H981 (See protein sequence)
Recommended Name: Actin-related protein 8  
Size: 624 amino acids; 70484 Da
Subunit: Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the
DBINO domain of INO80. Interacts with ACTR5; the interaction is observed in asynchronous (interphase) cells but not in
metaphase-arrested cells indicative for a possible dissociation of the INO80 complex in mitotic cells. Exists as
monomers and dimers, but the dimer is most probably the biologically relevant form required for stable interactions
with histones that exploits the twofold symmetry of the nucleosome core
Subcellular location: Nucleus. Chromosome. Note=Specifically localizes to mitotic chromosomes
Sequence caution: Sequence=BAB15402.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
1 PDB 3D structure from and Proteopedia for ACTR8:
4FO0 (3D)    
Secondary accessions: B3KSW7 Q8N566 Q9H663
Alternative splicing: 3 isoforms:  Q9H981-1   Q9H981-2   Q9H981-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ACTR8: NX_Q9H981

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9H981

  • ACTR8 Protein expression data from MOPED and PaxDb:    About this image 
    ACTR8 Protein Expression
    REFSEQ proteins: NP_075050.3  
    ENSEMBL proteins: 
     ENSP00000336842   ENSP00000419429   ENSP00000417230   ENSP00000417781   ENSP00000231909  

    Human Recombinant Protein Products for ACTR8: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for ACTR8 
    GenScript Custom Purified and Recombinant Proteins Services for ACTR8
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ACTR8

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA18026119
    GO:0031011Ino80 complex IDA--

    ACTR8 for ontologies           About GeneDecksing



    ACTR8 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for ACTR8 
    GenScript Custom Superior Antibodies Services for ACTR8
    Search for Antibodies for ACTR8 at Abcam  
    Uscn Antibodies for ACTR8
    Search ThermoFisher Antibodies for ACTR8

    Assay Products for ACTR8: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ACTR8
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for ACTR8


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ACTR8 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR004000 Actin-related

    Graphical View of Domain Structure for InterPro Entry Q9H981

    ProtoNet protein and cluster: Q9H981

    1 Blocks protein family: IPB004000 Actin/actin-like

    UniProtKB/Swiss-Prot: ARP8_HUMAN, Q9H981
    Similarity: Belongs to the actin family. ARP8 subfamily


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ARP8_HUMAN, Q9H981
    Function: Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase
    activity, and unable to polymerize
    Function: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional
    regulation, DNA reoplication and probably DNA repair. Required for the recruitment of INO80 (and probably the INO80
    complex) to sites of DNA damage. Strongly prefer nucleosomes and H3-H4 tetramers over H2A-H2B dimers, suggesting it
    may act as a nucleosome recognition module within the complex

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI18922472
    GO:0005524ATP binding IEA--
         
    ACTR8 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ACTR8:
     Increased cilium length after  

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ACTR8 

    miRNA
    Products:
        
    miRTarBase miRNAs that target ACTR8:
    hsa-mir-124 (MIRT002578)

    OriGene 3'-UTR Clone: ACTR8
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ACTR8
    8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate ACTR8 (see all 19):
    hsa-miR-520e hsa-miR-302d hsa-miR-607 hsa-miR-302e hsa-miR-512-3p hsa-miR-520a-3p hsa-miR-372 hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidACTR8 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ACTR8 (see all 7)
    OriGene shRNA RFP: ACTR8
    OriGene siRNA: ACTR8
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ACTR8
    Sirion Biotech Custom design and validation of potent shRNA sequences against ACTR8 

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ACTR8
    Sirion Biotech Customized adenovirus for overexpression of ACTR8 
    Sirion Biotech Customized adenovirus for potent knockdown of ACTR8

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ACTR8 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ACTR8
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: ACTR8 (NM_022899)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ACTR8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACTR8 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ACTR8
    Search LifeMap BioReagents cell lines for ACTR8
    Sirion Biotech Customized stable knockdown cell line services for ACTR8 
    Sirion Biotech Customized inducible knockdown cell line services for ACTR8
    Sirion Biotech Customized stable overexpressing cell line services for ACTR8
    Sirion Biotech Customized inducible overexpressing cell line services for ACTR8

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACTR8


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ACTR8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    5/182 Interacting proteins for ACTR8 (Q9H9811, 3 ENSP000003368424) via UniProtKB, MINT, STRING, and/or I2D (see all 182)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=2 
    HIST1H4BP628053I2D: score=2 
    HIST1H4CP628053I2D: score=2 
    HIST1H4DP628053I2D: score=2 
    HIST1H4EP628053I2D: score=2 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006281DNA repair IEA--
    GO:0006310DNA recombination IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0007067mitosis IEA--

    ACTR8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ACTR8
    Search CenterWatch for drugs/clinical trials and news about ACTR8 / ARP8 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ACTR8 gene: 
    NM_022899.4  

    Unigene Cluster for ACTR8:

    ARP8 actin-related protein 8 homolog (yeast)
    Hs.412186  [show with all ESTs]
    Unigene Representative Sequence: NM_022899
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000335754(uc003dhb.3 uc003dhc.3 uc003dhd.3) ENST00000488802
    ENST00000482349 ENST00000486794 ENST00000495993 ENST00000498740 ENST00000231909


    miRNA
    Products:
         
    OriGene 3'-UTR Clone: ACTR8
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ACTR8
    8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate ACTR8 (see all 19):
    hsa-miR-520e hsa-miR-302d hsa-miR-607 hsa-miR-302e hsa-miR-512-3p hsa-miR-520a-3p hsa-miR-372 hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidACTR8 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ACTR8 (see all 7)
    OriGene shRNA RFP: ACTR8
    OriGene siRNA: ACTR8
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ACTR8
    Sirion Biotech Custom design and validation of potent shRNA sequences against ACTR8 
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ACTR8 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ACTR8
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: ACTR8 (NM_022899)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ACTR8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACTR8 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ACTR8
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ACTR8
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ACTR8
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ACTR8

    Additional cDNA sequence: 

    AK022996.1 AK026232.1 AK094507.1 

    7 DOTS entries:

    DT.311103  DT.100763889  DT.99952469  DT.91760477  DT.120891686  DT.120891692  DT.75120344 

    24/158 AceView cDNA sequences (see all 158):

    BE735182 CA748581 BQ574223 AA317304 BM932277 AA721647 CN482108 AI828781 
    AA844516 BG433769 NM_022899 BM799803 AK022996 AI208233 AA732693 BI870554 
    AI971578 CD359052 BU069934 AI653554 AL600023 BX101744 AI350843 AI203628 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ACTR8    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c
    SP1:        -     -                                                                 -                                             
    SP2:                    -                                                           -                                             
    SP3:                                                                          -                                                   
    SP4:        -     -     -                                                                                                         
    SP5:                                                                                                                              


    ECgene alternative splicing isoforms for ACTR8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ACTR8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ACAAATAAGT
    ACTR8 Expression
    About this image
    See ACTR8 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ACTR8

    SOURCE GeneReport for Unigene cluster: Hs.412186
        SABiosciences Custom PCR Arrays for ACTR8

    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ACTR8
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ACTR8
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ACTR8
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ACTR8
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACTR8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ACTR8 gene from 9/27 species (see all 27)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Actr81 , 5 ARP8 actin-related protein 8 homolog (S. cerevisiae)5
    ARP8 actin-related protein 81
    89.1(n)1
    97.12(a)1
      14 (18.37 cM)5
    562491  NM_027493.31  NP_081769.21 
     299783375 
    chicken
    (Gallus gallus)
    Aves ACTR81 ARP8 actin-related protein 8 homolog (yeast) 79.05(n)
    90.68(a)
      415994  XM_414336.3  XP_414336.2 
    lizard
    (Anolis carolinensis)
    Reptilia ACTR86
    --
    86(a)
    1 ↔ 1
    2(160570128-160587245)
    African clawed frog
    (Xenopus laevis)
    Amphibia actr8-A-prov2 ARP8 actin-related protein 8 homolog (yeast) 75.64(n)    BC047960.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.76702 Danio rerio mRNA similar to ARP8 actin-related protein more 74.6(n)    BC044364.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Arp81 Actin-related protein 8 45.99(n)
    36.01(a)
      32769  NM_133023.3  NP_573251.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ARP8(YOR141C)4
    ARP81
    Nuclear actin-related protein involved in chromatin more4
    Arp8p1
    43.96(n)1
    30.96(a)1
      15(592587-589942)4
    8543091, 4  NP_014784.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ARP91 actin-related protein 9 45.79(n)
    33.03(a)
      834370  NM_203147.1  NP_974876.1 
    rice
    (Oryza sativa)
    Liliopsida Os04g01776001 hypothetical protein 46.25(n)
    34.08(a)
      4335089  NM_001058705.1  NP_001052170.1 


    ENSEMBL Gene Tree for ACTR8 (if available)
    TreeFam Gene Tree for ACTR8 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/346 NCBI SNPs in ACTR8 are shown (see all 346    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs98759621,2
    C,F,A,H--53900682(+) TTTTTG/ATATTT 1 -- ds50012Minor allele frequency- A:0.40NA CSA 5
    rs580650231,2
    C--53900682(+) TTTTT-/ATA   
      TTTTTA
    GTAGA
    1 -- ds50010--------
    rs126384531,2
    C,H--53900690(+) TTTTTA/TGTAGA 1 -- ds50010--------
    rs1469807561,2
    --53900797(+) GCCACC/GGCGCC 1 -- ds50010--------
    rs170535681,2
    C,F,H--53900829(+) TTTAAT/CGCAGA 1 -- ds500117Minor allele frequency- C:0.43NA EA NS WA CSA 994
    rs341678601,2
    C--53900862(+) AAATGT/-TTTTT 1 -- ds50012Minor allele frequency- -:0.25NA CSA 4
    rs1476531231,2
    --53900955(+) TGTGTA/GTATTT 1 -- ds50010--------
    rs170535691,2
    C,F,H--53901014(+) CGGATA/CAAAAA 1 -- ds500113Minor allele frequency- C:0.06NA NS EA CSA WA 1450
    rs1422495961,2
    --53901131(+) TCAGTC/TTTCAC 1 -- ut310--------
    rs1458041291,2
    --53901229(+) CAGTTA/GTAAGA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ACTR8 (53901093 - 53916229 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ACTR8: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ACTR8
    DNA2.0 Custom Variant and Variant Library Synthesis for ACTR8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ACTR8 for disorders           About GeneDecksing

    3 diseases for ACTR8:    About MalaCards
    chronic lymphocytic leukemia    lymphocytic leukemia    leukemia

    Human Genome Epidemiology (HuGE) Navigator: ACTR8 (1 document)

    Export disorders for ACTR8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ACTR8 gene, integrated from 9 sources (see all 23):
    (articles sorted by number of sources associating them with ACTR8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The actin-related protein hArp8 accumulates on the mitotic chromosomes and functions in chromosome alignment. (PubMed id 18163988)1, 2, 3 Aoyama N....Harata M. (2008)
    2. A mammalian chromatin remodeling complex with similarities to the yeast INO80 complex. (PubMed id 16230350)1, 2, 3 Jin J.... Conaway J.W. (2005)
    3. Structure of Actin-related protein 8 and its contribution to nucleosome binding. (PubMed id 22977180)1, 2 Gerhold C.B.... Hopfner K.P. (2012)
    4. Subunit organization of the human INO80 chromatin remodeling complex: An evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling. (PubMed id 21303910)1, 2 Chen L.... Conaway R.C. (2011)
    5. Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin-remodeling complex. (PubMed id 18922472)1, 2 Yao T....Conaway J.W. (2008)
    6. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    9. Yin Yang 1 extends the Myc-related transcription facto rs network in embryonic stem cells. (PubMed id 22210892)1 Vella P....Pasini D. (2012)
    10. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 93973 HGNC: 14672 AceView: ACTR8 Ensembl:ENSG00000113812 euGenes: HUgn93973
    ECgene: ACTR8 H-InvDB: ACTR8

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ACTR8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ACTR8 gene:
    Search GeneIP for patents involving ACTR8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for ACTR8  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ACTR8   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ACTR8  
     Browse OriGene Protein Over-expression Lysates   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for ACTR8   OriGene 3'-UTR Clone for ACTR8  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ACTR8   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ACTR8  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ACTR8   OriGene Custom Protein Services for ACTR8  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ACTR8
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ACTR8
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ACTR8
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ACTR8
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ACTR8
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ACTR8
     GenScript Custom Purified and Recombinant Proteins Services for ACTR8 GenScript cDNA clones with any tag delivered in your preferred vector for ACTR8
     GenScript Custom Assay Services for ACTR8 GenScript Custom Superior Antibodies Services for ACTR8
     GenScript Custom overexpressing Cell Line Services for ACTR8 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in ACTR8 promoter
     Search Chromatin IP Primers for ACTR8
     RT2 qPCR Primer Assay in human, mouse, rat ACTR8
     Search GNC Networks for ACTR8
     SABiosciences Custom PCR Arrays for ACTR8
     Search Tocris compounds for ACTR8
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Biologicals
     Novus Tissue Slides
     Search for Antibodies for ACTR8 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for ACTR8
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     ACTR8 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for ACTR8
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACTR8
     SwitchGear 3'UTR luciferase reporter plasmids for ACTR8
     SwitchGear Promoter luciferase reporter plasmids for ACTR8
     Search ThermoFisher Antibodies for ACTR8
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACTR8
     inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ACTR8
    Sirion Biotech Customized:
     stable knockdown cell line services for ACTR8
     inducible knockdown cell line services for ACTR8
     design and validation of potent shRNA sequences against ACTR8
     adenovirus for potent knockdown of ACTR8
     adenovirus for overexpression of ACTR8
     stable overexpressing cell line services for ACTR8
     inducible overexpressing cell line services for ACTR8
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 13 May 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ACTR8 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4