Aliases for ACTR8 Gene
External Ids for ACTR8 Gene
Previous GeneCards Identifiers for ACTR8 Gene
GeneCards Summary for ACTR8 Gene
ACTR8 (ARP8 Actin-Related Protein 8 Homolog) is a Protein Coding gene. Among its related pathways are DNA Double-Strand Break Repair and Transcription-Coupled Nucleotide Excision Repair (TC-NER).
UniProtKB/Swiss-Prot for ACTR8 Gene
Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize.
Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA reoplication and probably DNA repair. Required for the recruitment of INO80 (and probably the INO80 complex) to sites of DNA damage. Strongly prefer nucleosomes and H3-H4 tetramers over H2A-H2B dimers, suggesting it may act as a nucleosome recognition module within the complex.