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Aliases for ACTR6 Gene

Aliases for ACTR6 Gene

  • ARP6 Actin Related Protein 6 Homolog 2 3 5
  • HARP6 3 4
  • HARPX 3 4
  • ARP6 Actin-Related Protein 6 Homolog (Yeast) 2
  • Actin-Related Protein 6 3
  • HSPC281 3
  • MSTP136 3
  • CDA12 3
  • ARP6 3

External Ids for ACTR6 Gene

Previous GeneCards Identifiers for ACTR6 Gene

  • GC12P100527
  • GC12P099097
  • GC12P099096
  • GC12P099117
  • GC12P100594
  • GC12P097655

Summaries for ACTR6 Gene

GeneCards Summary for ACTR6 Gene

ACTR6 (ARP6 Actin Related Protein 6 Homolog) is a Protein Coding gene.

Additional gene information for ACTR6 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACTR6 Gene

Genomics for ACTR6 Gene

GeneHancer (GH) Regulatory Elements for ACTR6 Gene

Promoters and enhancers for ACTR6 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I100198 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 561.2 +2.0 1997 4.4 HDGF SMAD1 ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 POLR2B E2F8 ACTR6 ENSG00000257489 SCYL2 GOLGA2P5 ANKS1B GC12M100397
GH12I100266 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 20.7 +68.9 68853 3.6 HDGF PKNOX1 SMAD1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SCYL2 DEPDC4 ACTR6 RN7SL176P GC12M100395
GH12I101051 Enhancer 1.1 Ensembl ENCODE 14.2 +853.3 853277 2.7 FEZF1 ZNF2 GLIS2 ZNF213 FOS SP3 TSHZ1 ZNF518A NFIL3 GLIS1 ACTR6 UTP20 ENSG00000257543 GAS2L3 SNX5P2 ENSG00000258007 ANO4
GH12I100233 Enhancer 1.1 FANTOM5 Ensembl ENCODE 11.2 +35.4 35396 1.1 CTCF ESRRA PKNOX1 EBF1 RAD21 RFX5 CTBP1 ZNF143 SMC3 FOS ACTR6 ANKS1B GC12M100398 GC12P100217 DEPDC4
GH12I100163 Enhancer 1 Ensembl ENCODE 12 -35.1 -35073 1.2 PKNOX1 SIN3A FEZF1 ZBTB7B ZNF335 ZNF143 SMARCA5 SP3 ELF1 SREBF1 GC12M100393 PIR48175 PIR55599 PIR55619 PIR56508 PIR50064 PIR42520 PIR50984 GOLGA2P5 ACTR6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ACTR6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ACTR6 gene promoter:

Genomic Locations for ACTR6 Gene

Genomic Locations for ACTR6 Gene
chr12:100,199,122-100,241,865
(GRCh38/hg38)
Size:
42,744 bases
Orientation:
Plus strand
chr12:100,592,900-100,635,643
(GRCh37/hg19)

Genomic View for ACTR6 Gene

Genes around ACTR6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACTR6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACTR6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACTR6 Gene

Proteins for ACTR6 Gene

  • Protein details for ACTR6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZN1-ARP6_HUMAN
    Recommended name:
    Actin-related protein 6
    Protein Accession:
    Q9GZN1
    Secondary Accessions:
    • B3KW37
    • B4DLG9
    • Q53GH2
    • Q9BY39
    • Q9H8H6

    Protein attributes for ACTR6 Gene

    Size:
    396 amino acids
    Molecular mass:
    45810 Da
    Quaternary structure:
    • Interacts with CBX1, CBX3 and CBX5.

    Alternative splice isoforms for ACTR6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ACTR6 Gene

Post-translational modifications for ACTR6 Gene

No data available for DME Specific Peptides for ACTR6 Gene

Domains & Families for ACTR6 Gene

Gene Families for ACTR6 Gene

Protein Domains for ACTR6 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ACTR6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9GZN1

UniProtKB/Swiss-Prot:

ARP6_HUMAN :
  • Belongs to the actin family. ARP6 subfamily.
Family:
  • Belongs to the actin family. ARP6 subfamily.
genes like me logo Genes that share domains with ACTR6: view

Function for ACTR6 Gene

Gene Ontology (GO) - Molecular Function for ACTR6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15647280
genes like me logo Genes that share ontologies with ACTR6: view
genes like me logo Genes that share phenotypes with ACTR6: view

Animal Models for ACTR6 Gene

MGI Knock Outs for ACTR6:

Animal Model Products

CRISPR Products

miRNA for ACTR6 Gene

miRTarBase miRNAs that target ACTR6

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ACTR6 Gene

Localization for ACTR6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACTR6 Gene

Cytoplasm, cytoskeleton. Nucleus. Note=Colocalizes with HP1 family proteins at pericentric heterochromatin.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ACTR6 gene
Compartment Confidence
nucleus 4
plasma membrane 3
cytoskeleton 3
cytosol 3
peroxisome 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ACTR6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS,IEA --
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with ACTR6: view

Pathways & Interactions for ACTR6 Gene

SuperPathways for ACTR6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ACTR6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006338 chromatin remodeling IEA --
genes like me logo Genes that share ontologies with ACTR6: view

No data available for Pathways by source and SIGNOR curated interactions for ACTR6 Gene

Drugs & Compounds for ACTR6 Gene

No Compound Related Data Available

Transcripts for ACTR6 Gene

Unigene Clusters for ACTR6 Gene

ARP6 actin-related protein 6 homolog (yeast):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ACTR6 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b
SP1:
SP2: - -
SP3: - -
SP4: - - -
SP5: - -
SP6: - -
SP7:
SP8: -

Relevant External Links for ACTR6 Gene

GeneLoc Exon Structure for
ACTR6
ECgene alternative splicing isoforms for
ACTR6

Expression for ACTR6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ACTR6 Gene

Protein differential expression in normal tissues from HIPED for ACTR6 Gene

This gene is overexpressed in Serum (53.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ACTR6 Gene



Protein tissue co-expression partners for ACTR6 Gene

NURSA nuclear receptor signaling pathways regulating expression of ACTR6 Gene:

ACTR6

SOURCE GeneReport for Unigene cluster for ACTR6 Gene:

Hs.115088

Evidence on tissue expression from TISSUES for ACTR6 Gene

  • Nervous system(4.7)
  • Intestine(4.2)
genes like me logo Genes that share expression patterns with ACTR6: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ACTR6 Gene

Orthologs for ACTR6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ACTR6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ACTR6 34 33
  • 99.75 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ACTR6 34
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ACTR6 33 34
  • 95.54 (n)
dog
(Canis familiaris)
Mammalia ACTR6 33 34
  • 94.95 (n)
oppossum
(Monodelphis domestica)
Mammalia ACTR6 34
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Actr6 33 16 34
  • 89.48 (n)
rat
(Rattus norvegicus)
Mammalia Actr6 33
  • 88.8 (n)
chicken
(Gallus gallus)
Aves ACTR6 33 34
  • 83.59 (n)
lizard
(Anolis carolinensis)
Reptilia ACTR6 34
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia actr6 33
  • 79.04 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.14417 33
zebrafish
(Danio rerio)
Actinopterygii actr6 33 34
  • 75.08 (n)
wufc44c08 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4078 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005857 33
  • 54.37 (n)
fruit fly
(Drosophila melanogaster)
Insecta Arp6 33
  • 53.26 (n)
Actr13E 34
  • 46 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea arp-6 33 34
  • 51.65 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F19063g 33
  • 47.56 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARP6 33 34 36
  • 47.53 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR091W 33
  • 44.24 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons ARP6 33
  • 50.61 (n)
rice
(Oryza sativa)
Liliopsida Os01g0269900 33
  • 49.23 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 56 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes arp6 33
  • 51.43 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU05587 33
  • 47.61 (n)
Species where no ortholog for ACTR6 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ACTR6 Gene

ENSEMBL:
Gene Tree for ACTR6 (if available)
TreeFam:
Gene Tree for ACTR6 (if available)

Paralogs for ACTR6 Gene

Pseudogenes.org Pseudogenes for ACTR6 Gene

genes like me logo Genes that share paralogs with ACTR6: view

No data available for Paralogs for ACTR6 Gene

Variants for ACTR6 Gene

Sequence variations from dbSNP and Humsavar for ACTR6 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000093090 -- 100,215,528(+) T/C intron_variant
rs1000113729 -- 100,200,047(+) C/T upstream_transcript_variant
rs1000148765 -- 100,213,485(+) A/G intron_variant
rs1000193578 -- 100,205,465(+) A/G intron_variant
rs1000377215 -- 100,212,689(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ACTR6 Gene

Variant ID Type Subtype PubMed ID
esv3630550 CNV gain 21293372
esv3892256 CNV loss 25118596
nsv1048784 CNV gain 25217958
nsv559964 CNV gain 21841781

Variation tolerance for ACTR6 Gene

Residual Variation Intolerance Score: 24.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.81; 17.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ACTR6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ACTR6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACTR6 Gene

Disorders for ACTR6 Gene

Additional Disease Information for ACTR6

No disorders were found for ACTR6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ACTR6 Gene

Publications for ACTR6 Gene

  1. Novel actin-related proteins in vertebrates: similarities of structure and expression pattern to Arp6 localized on Drosophila heterochromatin. (PMID: 11368909) Kato M … Harata M (Gene 2001) 2 3 4 22 58
  2. Vertebrate Arp6, a novel nuclear actin-related protein, interacts with heterochromatin protein 1. (PMID: 16487625) Ohfuchi E … Harata M (European journal of cell biology 2006) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for ACTR6 Gene

Sources for ACTR6 Gene

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