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ACTR6 Gene

protein-coding   GIFtS: 50
GCID: GC12P100594

ARP6 Actin-Related Protein 6 Homolog (Yeast)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ARP6 Actin-Related Protein 6 Homolog (Yeast)1 2     MSTP1362
hARPX2 3     Actin-Related Protein 62
ARP62     hARP62
HSPC2812     hArp63

External Ids:    HGNC: 240251   Entrez Gene: 644312   Ensembl: ENSG000000750897   UniProtKB: Q9GZN13   

Export aliases for ACTR6 gene to outside databases

Previous GC identifers: GC12P100527 GC12P099097 GC12P099096 GC12P099117 GC12P097655


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ACTR6 Gene:
ACTR6 (ARP6 actin-related protein 6 homolog (yeast)) is a protein-coding gene. Diseases associated with ACTR6 include polycystic ovary syndrome, and obesity.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the ACTR6 gene promoter:
         AML1a   p300   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   Ik-3   POU3F2   GATA-1   HNF-1A   HNF-1   c-Myb   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidACTR6 promoter sequence
   Search Chromatin IP Primers for ACTR6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ACTR6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q23.1   Ensembl cytogenetic band:  12q23.1   HGNC cytogenetic band: 12q23.1

ACTR6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ACTR6 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P100594:  view genomic region     (about GC identifiers)

Start:
100,592,900 bp from pter      End:
100,635,643 bp from pter
Size:
42,744 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ARP6_HUMAN, Q9GZN1 (See protein sequence)
Recommended Name: Actin-related protein 6  
Size: 396 amino acids; 45810 Da
Secondary accessions: B3KW37 Q9BY39 Q9H8H6

Explore the universe of human proteins at neXtProt for ACTR6: NX_Q9GZN1

Explore proteomics data for ACTR6 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys38
  • Modification sites at PhosphoSitePlus

  • See ACTR6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_071941.1  
    ENSEMBL proteins: 
     ENSP00000448508   ENSP00000447641   ENSP00000188312   ENSP00000448669   ENSP00000447565  
     ENSP00000450330   ENSP00000448447   ENSP00000447237   ENSP00000448356  

    ACTR6 Human Recombinant Protein Products:

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    Novus Biologicals ACTR6 Protein
    Novus Biologicals ACTR6 Lysate
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    Cloud-Clone Corp. Proteins for ACTR6

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    Abcam antibodies for ACTR6
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    Search ThermoFisher Antibodies for ACTR6
    LSBio Antibodies in human, mouse, rat for ACTR6

    ACTR6 Assay Products:

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    Cloud-Clone Corp. ELISAs for ACTR6
    Cloud-Clone Corp. CLIAs for ACTR6


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR004000 Actin-related

    Graphical View of Domain Structure for InterPro Entry Q9GZN1

    ProtoNet protein and cluster: Q9GZN1

    1 Blocks protein domain: IPB004000 Actin/actin-like

    UniProtKB/Swiss-Prot: ARP6_HUMAN, Q9GZN1
    Similarity: Belongs to the actin family. ARP6 subfamily


    ACTR6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15647280
         
    ACTR6 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ACTR6:
     Decreased POU5F1-GFP protein e 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ACTR6
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ACTR6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ACTR6
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ACTR6

    miRNA
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    Block miRNA regulation of human, mouse, rat ACTR6 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate ACTR6:
    hsa-miR-582-5p hsa-miR-586 hsa-miR-548l
    SwitchGear 3'UTR luciferase reporter plasmidACTR6 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ACTR6
    Predesigned siRNA for gene silencing in human, mouse, rat ACTR6

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ACTR6

    Clone
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    OriGene clones in human, mouse for ACTR6 (see all 7)
    OriGene ORF clones in mouse, rat for ACTR6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ACTR6 (NM_022496)
    Sino Biological Human cDNA Clone for ACTR6
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACTR6

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACTR6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ARP6_HUMAN, Q9GZN1: Cytoplasm, cytoskeleton (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton2
    cytosol2
    nucleus2
    peroxisome2
    plasma membrane2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005856cytoskeleton IEA--

    ACTR6 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ACTR6
    Interactions:

        GeneGlobe Interaction Network for ACTR6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ACTR6 (Q9GZN11, 2, 3 ENSP000001883124) via UniProtKB, MINT, STRING, and/or I2D (see all 233)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ZNHIT1O432571, 2, 3, ENSP000003045934EBI-769329,EBI-347522 MINT-7986203 MINT-7986166 I2D: score=2 STRING: ENSP00000304593
    H2AFZP0C0S52, 3, ENSP000002964174MINT-7986188 MINT-7986166 I2D: score=1 STRING: ENSP00000296417
    DMAP1Q9NPF53, ENSP000003126974I2D: score=2 STRING: ENSP00000312697
    RUVBL2Q9Y2303, ENSP000002214134I2D: score=2 STRING: ENSP00000221413
    FSCN1Q166583, ENSP000003717984I2D: score=1 STRING: ENSP00000371798
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ACTR6 (ARP6)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ACTR6 gene: 
    NM_022496.4  

    Unigene Cluster for ACTR6:

    ARP6 actin-related protein 6 homolog (yeast)
    Hs.115088  [show with all ESTs]
    Unigene Representative Sequence: NM_022496
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000551652 ENST00000553038(uc009ztu.2) ENST00000188312(uc001thb.1 uc001thc.1)
    ENST00000551517(uc010svh.2) ENST00000546902(uc001the.1) ENST00000550813
    ENST00000549977 ENST00000547458 ENST00000548180 ENST00000551440 ENST00000552064
    ENST00000552376 ENST00000551617
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ACTR6 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate ACTR6:
    hsa-miR-582-5p hsa-miR-586 hsa-miR-548l
    SwitchGear 3'UTR luciferase reporter plasmidACTR6 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ACTR6
    Predesigned siRNA for gene silencing in human, mouse, rat ACTR6
    Clone
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    OriGene clones in human, mouse for ACTR6 (see all 7)
    OriGene ORF clones in mouse, rat for ACTR6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ACTR6 (NM_022496)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ACTR6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACTR6
    Primer
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    OriGene qPCR primer pairs and template standards for ACTR6
    OriGene qSTAR qPCR primer pairs in human, mouse for ACTR6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ACTR6
      QuantiTect SYBR Green Assays in human, mouse, rat ACTR6
      QuantiFast Probe-based Assays in human, mouse, rat ACTR6

    Additional mRNA sequence: 

    AB038229.1 AF161399.1 AF175226.1 AF212251.1 AK023495.1 AK023684.1 AK124075.1 AK222959.1 
    BC015107.1 BC042997.1 BC050679.1 NR_048568.1 NR_048569.1 

    10 DOTS entries:

    DT.313110  DT.121166024  DT.75197569  DT.100732033  DT.95313520  DT.100811429  DT.209725  DT.91752912 
    DT.100768747  DT.121165843 

    Selected AceView cDNA sequences (see all 184):

    CR622632 BC050679 CB107189 CR609733 CR614672 CR598015 CR592230 AF161399 
    CB135972 BX458860 AA315526 CA424635 BM787230 AW674643 CA448434 BX399703 
    BU689468 BX460161 AW070869 BX421689 CR615608 BQ573921 CB121667 CR596881 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ACTR6 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b
    SP1:                                                                                                                                                      
    SP2:                                                                                                                    -     -                           
    SP3:                                            -                             -                                                                           
    SP4:                                -           -           -                                                                                             
    SP5:                                            -           -                                                                                             


    ECgene alternative splicing isoforms for ACTR6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ACTR6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATATTGCAA
    ACTR6 Expression
    About this image

    ACTR6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ACTR6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.115088
        Custom PCR Arrays for ACTR6
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACTR6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ACTR6 gene from Selected species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Actr61 , 5 ARP6 actin-related protein 6 homolog (yeast)5
    ARP6 actin-related protein 61
    89.48(n)1
    98.48(a)1
      10 (45.14 cM)5
    670191  NM_025914.21  NP_080190.11 
     897119735 
    chicken
    (Gallus gallus)
    Aves ACTR61 ARP6 actin-related protein 6 homolog (yeast) 83.59(n)
    95.2(a)
      395348  NM_204637.1  NP_989968.1 
    lizard
    (Anolis carolinensis)
    Reptilia ACTR66
    ARP6 actin-related protein 6 homolog (yeast)
    84(a)
    1 ↔ 1
    5(28714053-28728361)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.144172 Xenopus laevis transcribed sequence with moderate similarity more 79.49(n)    CB209651.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc44c082 wufc44c08 76.51(n)   324822  BC045961.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Arp61 Actin-related protein 6 53.26(n)
    49.21(a)
      32514  NM_078610.3  NP_511165.1 
    worm
    (Caenorhabditis elegans)
    Secernentea arp-61 arp-6 51.65(n)
    40.21(a)
      174288  NM_063280.5  NP_495681.4 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ARP6(YLR085C)4
    ARP61
    Actin-related protein that binds nucleosomes; a component more4
    ARP61
    47.53(n)1
    34.23(a)1
      12(301989-300673)4
    8507741, 4  NP_013186.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ARP61 ARP6 50.61(n)
    39.27(a)
      823150  NM_114070.3  NP_566861.1 
    rice
    (Oryza sativa)
    Liliopsida Os01g02699001 Os01g0269900 49.23(n)
    40.46(a)
      4326270  NM_001049235.1  NP_001042700.1 


    ENSEMBL Gene Tree for ACTR6 (if available)
    TreeFam Gene Tree for ACTR6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ACTR6 gene
    13 SIMAP similar genes for ACTR6 using alignment to 8 protein entries:     ARP6_HUMAN (see all proteins):
    ACTR2    ACT    ACTB    ACTBL2    POTEM    PS1TP5BP1
    ACTG1    ACTA1    ACTA2    ACTC1    ACTG2    ACTR1B
    POTEKP

    ACTR6 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ACTR6
    PGOHUM00000261381


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ACTR6 (see all 495)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1457235401,2
    --100591972(+) AGCGCA/GGAAGA 1 -- us2k10--------
    rs1383189331,2
    --100591981(+) GAGGAA/GTGAGA 1 -- us2k10--------
    rs1892273161,2
    --100592007(+) CACAGC/GAGCCA 1 -- us2k10--------
    rs1428085391,2
    --100592024(+) GAGCAC/TAGCCT 1 -- us2k10--------
    rs1158830481,2
    C,F--100592355(+) CCCTGC/ACCACT 1 -- us2k11Minor allele frequency- A:0.05WA 118
    rs1144044491,2
    F--100592484(+) TGGTTT/GGAGCC 1 -- us2k11Minor allele frequency- G:0.02WA 118
    rs762631841,2
    C,F--100592518(+) CAACAT/AAGCGA 1 -- us2k13Minor allele frequency- A:0.05NA 124
    rs111102861,2
    A--100592582(+) acacaA/Caaaaa 3 -- us2k10--------
    rs1164909511,2
    C,F--100592594(+) CATTTT/CTTAAA 3 -- us2k11Minor allele frequency- C:0.04WA 118
    rs1810229411,2
    --100592631(+) GGTCCC/TGGATA 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for ACTR6 (100592900 - 100635643 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for ACTR6: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ACTR6
    DNA2.0 Custom Variant and Variant Library Synthesis for ACTR6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    3 diseases for ACTR6:    About MalaCards
    polycystic ovary syndrome    obesity    malaria


    ACTR6 for disorders           About GeneDecksing


    Export disorders for ACTR6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ACTR6 gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with ACTR6)
        Utopia: connect your pdf to the dynamic
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    1. Novel actin-related proteins in vertebrates: similarities of structure and expression pattern to Arp6 localized on Drosophila heterochromatin. (PubMed id 11368909)1, 2, 3, 9 Kato M.... Harata M. (Gene 2001)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. H2A.Z.2.2 is an alternatively spliced histone H2A.Z variant that causes severe nucleosome destabilization. (PubMed id 22467210)1 BAPnisch C....Hake S.B. (Nucleic Acids Res. 2012)
    5. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    6. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    7. Essential role of p18Hamlet/SRCAP-mediated histone H2A.Z chromatin incorporation in muscle differentiation. (PubMed id 20473270)1 Cuadrado A....Nebreda A.R. (EMBO J. 2010)
    8. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (Anal. Chem. 2009)
    9. Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (Science 2009)
    10. Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. (PubMed id 17643375)1 Jeronimo C.... Coulombe B. (Mol. Cell 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 64431 HGNC: 24025 AceView: ACTR6 Ensembl:ENSG00000075089 euGenes: HUgn64431
    ECgene: ACTR6 H-InvDB: ACTR6

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ACTR6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ACTR6 gene:
    Search GeneIP for patents involving ACTR6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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