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Aliases for ACTR6 Gene

Aliases for ACTR6 Gene

  • ARP6 Actin-Related Protein 6 Homolog (Yeast) 2 3
  • HARP6 3 4
  • HARPX 3 4
  • HSPC281 3
  • MSTP136 3
  • CDA12 3
  • ARP6 3

External Ids for ACTR6 Gene

Previous GeneCards Identifiers for ACTR6 Gene

  • GC12P100527
  • GC12P099097
  • GC12P099096
  • GC12P099117
  • GC12P100594
  • GC12P097655

Summaries for ACTR6 Gene

GeneCards Summary for ACTR6 Gene

ACTR6 (ARP6 Actin-Related Protein 6 Homolog (Yeast)) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACTR6 Gene

Genomics for ACTR6 Gene

Regulatory Elements for ACTR6 Gene

Genomic Location for ACTR6 Gene

Chromosome:
12
Start:
100,199,122 bp from pter
End:
100,241,865 bp from pter
Size:
42,744 bases
Orientation:
Plus strand

Genomic View for ACTR6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ACTR6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACTR6 Gene

Proteins for ACTR6 Gene

  • Protein details for ACTR6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZN1-ARP6_HUMAN
    Recommended name:
    Actin-related protein 6
    Protein Accession:
    Q9GZN1
    Secondary Accessions:
    • B3KW37
    • B4DLG9
    • Q53GH2
    • Q9BY39
    • Q9H8H6

    Protein attributes for ACTR6 Gene

    Size:
    396 amino acids
    Molecular mass:
    45810 Da
    Quaternary structure:
    • Interacts with CBX1, CBX3 and CBX5.

    Alternative splice isoforms for ACTR6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ACTR6 Gene

Proteomics data for ACTR6 Gene at MOPED

Post-translational modifications for ACTR6 Gene

  • Ubiquitination at Lys 38
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ACTR6 Gene

Domains & Families for ACTR6 Gene

Protein Domains for ACTR6 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ACTR6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9GZN1

UniProtKB/Swiss-Prot:

ARP6_HUMAN :
  • Belongs to the actin family. ARP6 subfamily.
Family:
  • Belongs to the actin family. ARP6 subfamily.
genes like me logo Genes that share domains with ACTR6: view

No data available for Gene Families for ACTR6 Gene

Function for ACTR6 Gene

Gene Ontology (GO) - Molecular Function for ACTR6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15647280
genes like me logo Genes that share ontologies with ACTR6: view

Phenotypes for ACTR6 Gene

genes like me logo Genes that share phenotypes with ACTR6: view

Animal Model Products

miRNA for ACTR6 Gene

miRTarBase miRNAs that target ACTR6

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ACTR6

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for ACTR6 Gene

Localization for ACTR6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACTR6 Gene

Cytoplasm, cytoskeleton. Nucleus. Note=Colocalizes with HP1 family proteins at pericentric heterochromatin.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ACTR6 Gene COMPARTMENTS Subcellular localization image for ACTR6 gene
Compartment Confidence
cytoskeleton 3
nucleus 3
cytosol 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for ACTR6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0031011 Ino80 complex IEA --
GO:0035267 NuA4 histone acetyltransferase complex IEA --
genes like me logo Genes that share ontologies with ACTR6: view

Pathways & Interactions for ACTR6 Gene

SuperPathways for ACTR6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ACTR6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IEA --
GO:0006338 chromatin remodeling IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ACTR6: view

No data available for Pathways by source and SIGNOR curated interactions for ACTR6 Gene

Drugs & Compounds for ACTR6 Gene

No Compound Related Data Available

Transcripts for ACTR6 Gene

Unigene Clusters for ACTR6 Gene

ARP6 actin-related protein 6 homolog (yeast):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ACTR6

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ACTR6 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b
SP1:
SP2: - -
SP3: - -
SP4: - - -
SP5: - -
SP6: - -
SP7:
SP8: -

Relevant External Links for ACTR6 Gene

GeneLoc Exon Structure for
ACTR6
ECgene alternative splicing isoforms for
ACTR6

Expression for ACTR6 Gene

mRNA expression in normal human tissues for ACTR6 Gene

Protein differential expression in normal tissues from HIPED for ACTR6 Gene

This gene is overexpressed in Serum (53.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ACTR6 Gene



SOURCE GeneReport for Unigene cluster for ACTR6 Gene Hs.115088

genes like me logo Genes that share expression patterns with ACTR6: view

Protein tissue co-expression partners for ACTR6 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ACTR6 Gene

Orthologs for ACTR6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ACTR6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ACTR6 35
  • 95.54 (n)
  • 99.24 (a)
ACTR6 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ACTR6 35
  • 94.95 (n)
  • 100 (a)
ACTR6 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Actr6 35
  • 89.48 (n)
  • 98.48 (a)
Actr6 16
Actr6 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ACTR6 35
  • 99.75 (n)
  • 100 (a)
ACTR6 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Actr6 35
  • 88.8 (n)
  • 98.74 (a)
oppossum
(Monodelphis domestica)
Mammalia ACTR6 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ACTR6 36
  • 97 (a)
OneToOne
chicken
(Gallus gallus)
Aves ACTR6 35
  • 83.59 (n)
  • 95.2 (a)
ACTR6 36
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ACTR6 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia actr6 35
  • 79.04 (n)
  • 90.15 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.14417 35
zebrafish
(Danio rerio)
Actinopterygii actr6 35
  • 75.08 (n)
  • 83.59 (a)
wufc44c08 35
actr6 36
  • 83 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4078 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005857 35
  • 54.37 (n)
  • 54.2 (a)
fruit fly
(Drosophila melanogaster)
Insecta Arp6 35
  • 53.26 (n)
  • 49.21 (a)
Actr13E 36
  • 46 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea arp-6 35
  • 51.65 (n)
  • 40.21 (a)
arp-6 36
  • 35 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR091W 35
  • 44.24 (n)
  • 32.98 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F19063g 35
  • 47.56 (n)
  • 33.6 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARP6 35
  • 47.53 (n)
  • 34.23 (a)
ARP6 36
  • 29 (a)
OneToOne
ARP6 38
thale cress
(Arabidopsis thaliana)
eudicotyledons ARP6 35
  • 50.61 (n)
  • 39.27 (a)
rice
(Oryza sativa)
Liliopsida Os01g0269900 35
  • 49.23 (n)
  • 40.46 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU05587 35
  • 47.61 (n)
  • 38.97 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes arp6 35
  • 51.43 (n)
  • 41.04 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 56 (a)
OneToOne
Species with no ortholog for ACTR6:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ACTR6 Gene

ENSEMBL:
Gene Tree for ACTR6 (if available)
TreeFam:
Gene Tree for ACTR6 (if available)

Paralogs for ACTR6 Gene

Pseudogenes.org Pseudogenes for ACTR6 Gene

genes like me logo Genes that share paralogs with ACTR6: view

No data available for Paralogs for ACTR6 Gene

Variants for ACTR6 Gene

Sequence variations from dbSNP and Humsavar for ACTR6 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1391690 -- 100,201,284(+) GATTA(G/T)AGGTT intron-variant
rs2114916 -- 100,202,078(-) ggtgc(A/G)caact intron-variant
rs2303626 -- 100,200,887(-) TTGGC(A/G)TTGTA reference, synonymous-codon, nc-transcript-variant
rs2559848 -- 100,199,305(-) CCCAG(G/T)CTCCT upstream-variant-2KB
rs3811163 -- 100,199,403(+) AGGCC(A/G)ACGTT upstream-variant-2KB

Variation tolerance for ACTR6 Gene

Residual Variation Intolerance Score: 24.92% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.81; 17.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ACTR6 Gene

HapMap Linkage Disequilibrium report
ACTR6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ACTR6 Gene

Disorders for ACTR6 Gene

Relevant External Links for ACTR6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ACTR6
genes like me logo Genes that share disorders with ACTR6: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ACTR6 Gene

Publications for ACTR6 Gene

  1. Novel actin-related proteins in vertebrates: similarities of structure and expression pattern to Arp6 localized on Drosophila heterochromatin. (PMID: 11368909) Kato M. … Harata M. (Gene 2001) 2 23 67
  2. Pioglitazone administration alters ovarian gene expression in aging obese lethal yellow mice. (PMID: 18348723) Brannian J.D. … Diggins M. (Reprod. Biol. Endocrinol. 2008) 23 67
  3. EARLY IN SHORT DAYS 1 (ESD1) encodes ACTIN-RELATED PROTEIN 6 (AtARP6), a putative component of chromatin remodelling complexes that positively regulates FLC accumulation in Arabidopsis. (PMID: 16495307) Martin-Trillo M. … Jarillo J.A. (Development 2006) 23 67
  4. Comparative genome analysis reveals a conserved family of actin-like proteins in apicomplexan parasites. (PMID: 16343347) Gordon J.L. … Sibley L.D. (BMC Genomics 2005) 23 67
  5. Toward a definition of self: proteomic evaluation of the class I peptide repertoire. (PMID: 14978097) Hickman H.D. … Hildebrand W.H. (J. Immunol. 2004) 23 67

Products for ACTR6 Gene

Sources for ACTR6 Gene

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