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Aliases for ACTR5 Gene

Aliases for ACTR5 Gene

  • ARP5 Actin-Related Protein 5 Homolog 2 3
  • ARP5 Actin-Related Protein 5 Homolog (Yeast) 2 5
  • Sarcoma Antigen NY-SAR-16 3 4
  • INO80 Complex Subunit M 2 3
  • HARP5 3 4
  • Arp5 3 4
  • ARP5 (Actin-Related Protein 5, Yeast) Homolog 2
  • INO80M 3

External Ids for ACTR5 Gene

Previous GeneCards Identifiers for ACTR5 Gene

  • GC00U991039
  • GC20P038063
  • GC20P036810
  • GC20P037377
  • GC20P034114

Summaries for ACTR5 Gene

GeneCards Summary for ACTR5 Gene

ACTR5 (ARP5 Actin-Related Protein 5 Homolog) is a Protein Coding gene. Among its related pathways are Transcription-Coupled Nucleotide Excision Repair (TC-NER) and DNA Double-Strand Break Repair.

UniProtKB/Swiss-Prot for ACTR5 Gene

  • Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Involved in DNA double-strand break repair and UV-damage excision repair.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACTR5 Gene

Genomics for ACTR5 Gene

Regulatory Elements for ACTR5 Gene

Enhancers for ACTR5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ACTR5 on UCSC Golden Path with GeneCards custom track

Promoters for ACTR5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ACTR5 on UCSC Golden Path with GeneCards custom track

Genomic Location for ACTR5 Gene

Chromosome:
20
Start:
38,748,258 bp from pter
End:
38,772,520 bp from pter
Size:
24,263 bases
Orientation:
Plus strand

Genomic View for ACTR5 Gene

Genes around ACTR5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACTR5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACTR5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACTR5 Gene

Proteins for ACTR5 Gene

  • Protein details for ACTR5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H9F9-ARP5_HUMAN
    Recommended name:
    Actin-related protein 5
    Protein Accession:
    Q9H9F9
    Secondary Accessions:
    • Q86WF7
    • Q8IUY5
    • Q8N724
    • Q9BRN0
    • Q9BVB7

    Protein attributes for ACTR5 Gene

    Size:
    607 amino acids
    Molecular mass:
    68297 Da
    Quaternary structure:
    • Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the helicase ATP-binding and the helicase C-terminal domain of INO80. Interacts with DDB1. Interacts with ACTR8; the interaction is observed in asynchronous (interphase) cells but not in metaphase-arrested cells indicative for a possible dissociation of the INO80 complex in mitotic cells.
    SequenceCaution:
    • Sequence=AAO65164.1; Type=Frameshift; Positions=319, 343, 347; Evidence={ECO:0000305};

neXtProt entry for ACTR5 Gene

Proteomics data for ACTR5 Gene at MOPED

Post-translational modifications for ACTR5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ACTR5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ACTR5 Gene

Domains & Families for ACTR5 Gene

Gene Families for ACTR5 Gene

Protein Domains for ACTR5 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ACTR5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H9F9

UniProtKB/Swiss-Prot:

ARP5_HUMAN :
  • Belongs to the actin family. ARP5 subfamily.
Family:
  • Belongs to the actin family. ARP5 subfamily.
genes like me logo Genes that share domains with ACTR5: view

Function for ACTR5 Gene

Molecular function for ACTR5 Gene

UniProtKB/Swiss-Prot Function:
Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Involved in DNA double-strand break repair and UV-damage excision repair.
genes like me logo Genes that share phenotypes with ACTR5: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ACTR5 Gene

Localization for ACTR5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACTR5 Gene

Nucleus. Cytoplasm. Note=Predominantly nuclear but undergoes nucleo-cytoplasmic shuttling (PubMed:19014934). Localized to interphase nuclei, but not nucleoli; excluded from chromosomes as mitosis progresses (PubMed:18163988).

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ACTR5 Gene COMPARTMENTS Subcellular localization image for ACTR5 gene
Compartment Confidence
nucleus 5
cytosol 3

No data available for Gene Ontology (GO) - Cellular Components for ACTR5 Gene

Pathways & Interactions for ACTR5 Gene

genes like me logo Genes that share pathways with ACTR5: view

Gene Ontology (GO) - Biological Process for ACTR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0070914 UV-damage excision repair IMP 20855601
genes like me logo Genes that share ontologies with ACTR5: view

No data available for SIGNOR curated interactions for ACTR5 Gene

Drugs & Compounds for ACTR5 Gene

No Compound Related Data Available

Transcripts for ACTR5 Gene

Unigene Clusters for ACTR5 Gene

ARP5 actin-related protein 5 homolog (yeast):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ACTR5 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP1:
SP2:

Relevant External Links for ACTR5 Gene

GeneLoc Exon Structure for
ACTR5
ECgene alternative splicing isoforms for
ACTR5

Expression for ACTR5 Gene

mRNA expression in normal human tissues for ACTR5 Gene

Protein differential expression in normal tissues from HIPED for ACTR5 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (18.5), Breast (12.8), Bone marrow mesenchymal stem cell (7.4), and Blymphocyte (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ACTR5 Gene



SOURCE GeneReport for Unigene cluster for ACTR5 Gene Hs.371585

genes like me logo Genes that share expression patterns with ACTR5: view

Protein tissue co-expression partners for ACTR5 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ACTR5 Gene

Orthologs for ACTR5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ACTR5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ACTR5 35
  • 87.97 (n)
  • 92.42 (a)
ACTR5 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ACTR5 35
  • 90.34 (n)
  • 93.71 (a)
ACTR5 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Actr5 35
  • 85.14 (n)
  • 90.17 (a)
Actr5 16
Actr5 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ACTR5 35
  • 99.51 (n)
  • 99.51 (a)
ACTR5 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Actr5 35
  • 84.25 (n)
  • 92.68 (a)
oppossum
(Monodelphis domestica)
Mammalia ACTR5 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 72 (a)
OneToMany
-- 36
  • 83 (a)
OneToMany
chicken
(Gallus gallus)
Aves ACTR5 35
  • 75.85 (n)
  • 79.93 (a)
ACTR5 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ACTR5 36
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia actr5 35
  • 67.9 (n)
  • 70.14 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16529 35
zebrafish
(Danio rerio)
Actinopterygii actr5 35
  • 62.53 (n)
  • 59.89 (a)
Dr.26688 35
actr5 36
  • 56 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004488 35
  • 50.45 (n)
  • 45.4 (a)
fruit fly
(Drosophila melanogaster)
Insecta Arp5 35
  • 51.69 (n)
  • 42.35 (a)
Arp5 36
  • 33 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL253C 35
  • 47.9 (n)
  • 37.4 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F03421g 35
  • 44.4 (n)
  • 35.55 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARP5 35
  • 44.51 (n)
  • 33.52 (a)
ARP5 36
  • 24 (a)
OneToOne
ARP5 38
thale cress
(Arabidopsis thaliana)
eudicotyledons ARP5 35
  • 49.21 (n)
  • 40.15 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06394 35
  • 46.97 (n)
  • 37.83 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes arp5 35
  • 46.14 (n)
  • 39.43 (a)
Species with no ortholog for ACTR5:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ACTR5 Gene

ENSEMBL:
Gene Tree for ACTR5 (if available)
TreeFam:
Gene Tree for ACTR5 (if available)

Paralogs for ACTR5 Gene

No data available for Paralogs for ACTR5 Gene

Variants for ACTR5 Gene

Sequence variations from dbSNP and Humsavar for ACTR5 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs17853829 - 38,755,074(+) AAGGC(A/G/T)GCAGC reference, missense
rs2245231 - 38,767,477(+) AGGAC(A/G/T)TTCAG reference, missense, utr-variant-3-prime
rs3752289 - 38,771,731(+) CCTGC(A/C/T)GAAGC reference, missense
rs35805905 - 38,766,325(-) TCCTA(A/T)GAGAG reference, synonymous-codon, missense
rs911720 -- 38,771,299(-) AGTGG(C/T)TCAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ACTR5 Gene

Variant ID Type Subtype PubMed ID
dgv4568n71 CNV Loss 21882294

Variation tolerance for ACTR5 Gene

Residual Variation Intolerance Score: 33.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.64; 56.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ACTR5 Gene

HapMap Linkage Disequilibrium report
ACTR5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACTR5 Gene

Disorders for ACTR5 Gene

Relevant External Links for ACTR5

Genetic Association Database (GAD)
ACTR5
Human Genome Epidemiology (HuGE) Navigator
ACTR5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ACTR5

No disorders were found for ACTR5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ACTR5 Gene

Publications for ACTR5 Gene

  1. A mammalian chromatin remodeling complex with similarities to the yeast INO80 complex. (PMID: 16230350) Jin J. … Conaway J.W. (J. Biol. Chem. 2005) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. Biological insights from 108 schizophrenia-associated genetic loci. (PMID: 25056061) (Nature 2014) 3

Products for ACTR5 Gene

Sources for ACTR5 Gene

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