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Aliases for ACTR5 Gene

Aliases for ACTR5 Gene

  • ARP5 Actin-Related Protein 5 Homolog (Yeast) 2 3
  • Sarcoma Antigen NY-SAR-16 3 4
  • INO80 Complex Subunit M 2 3
  • HARP5 3 4
  • Arp5 3 4
  • ARP5 (Actin-Related Protein 5, Yeast) Homolog 2
  • Actin-Related Protein 5 3
  • INO80M 3

External Ids for ACTR5 Gene

Previous GeneCards Identifiers for ACTR5 Gene

  • GC00U991039
  • GC20P038063
  • GC20P036810
  • GC20P037377
  • GC20P034114

Summaries for ACTR5 Gene

GeneCards Summary for ACTR5 Gene

ACTR5 (ARP5 Actin-Related Protein 5 Homolog (Yeast)) is a Protein Coding gene.

UniProtKB/Swiss-Prot for ACTR5 Gene

  • Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Involved in DNA double-strand break repair and UV-damage excision repair.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACTR5 Gene

Genomics for ACTR5 Gene

Regulatory Elements for ACTR5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ACTR5 Gene

38,748,294 bp from pter
38,772,520 bp from pter
24,227 bases
Plus strand

Genomic View for ACTR5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ACTR5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACTR5 Gene

Proteins for ACTR5 Gene

  • Protein details for ACTR5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Actin-related protein 5
    Protein Accession:
    Secondary Accessions:
    • Q86WF7
    • Q8IUY5
    • Q8N724
    • Q9BRN0
    • Q9BVB7

    Protein attributes for ACTR5 Gene

    607 amino acids
    Molecular mass:
    68297 Da
    Quaternary structure:
    • Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the helicase ATP-binding and the helicase C-terminal domain of INO80. Interacts with DDB1. Interacts with ACTR8; the interaction is observed in asynchronous (interphase) cells but not in metaphase-arrested cells indicative for a possible dissociation of the INO80 complex in mitotic cells.
    • Sequence=AAO65164.1; Type=Frameshift; Positions=319, 343, 347; Evidence={ECO:0000305};

neXtProt entry for ACTR5 Gene

Proteomics data for ACTR5 Gene at MOPED

Post-translational modifications for ACTR5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ACTR5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ACTR5 Gene

Domains for ACTR5 Gene

Gene Families for ACTR5 Gene

Protein Domains for ACTR5 Gene


Suggested Antigen Peptide Sequences for ACTR5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the actin family. ARP5 subfamily.
  • Belongs to the actin family. ARP5 subfamily.
genes like me logo Genes that share domains with ACTR5: view

Function for ACTR5 Gene

Molecular function for ACTR5 Gene

UniProtKB/Swiss-Prot Function:
Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Involved in DNA double-strand break repair and UV-damage excision repair.

Gene Ontology (GO) - Molecular Function for ACTR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16230350
genes like me logo Genes that share ontologies with ACTR5: view

Phenotypes for ACTR5 Gene

GenomeRNAi human phenotypes for ACTR5:
genes like me logo Genes that share phenotypes with ACTR5: view

Animal Model Products

miRNA for ACTR5 Gene

miRTarBase miRNAs that target ACTR5

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for ACTR5 Gene

Localization for ACTR5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACTR5 Gene

Nucleus. Cytoplasm. Note=Predominantly nuclear but undergoes nucleo-cytoplasmic shuttling. Localized to interphase nuclei, but not nucleoli; excluded from chromosomes as mitosis progresses.

Subcellular locations from

Jensen Localization Image for ACTR5 Gene COMPARTMENTS Subcellular localization image for ACTR5 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for ACTR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 18026119
GO:0005737 cytoplasm IDA 19014934
GO:0031011 Ino80 complex IDA 18026119
genes like me logo Genes that share ontologies with ACTR5: view

Pathways for ACTR5 Gene

SuperPathways for ACTR5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ACTR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006302 double-strand break repair IMP 19014934
GO:0006310 DNA recombination IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0070914 UV-damage excision repair IMP 20855601
genes like me logo Genes that share ontologies with ACTR5: view

No data available for Pathways by source for ACTR5 Gene

Transcripts for ACTR5 Gene

Unigene Clusters for ACTR5 Gene

ARP5 actin-related protein 5 homolog (yeast):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ACTR5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ACTR5 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9

Relevant External Links for ACTR5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ACTR5 Gene

mRNA expression in normal human tissues for ACTR5 Gene

Protein differential expression in normal tissues for ACTR5 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (18.5), Breast (12.8), Bone marrow mesenchymal stem cell (7.4), and Blymphocyte (6.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ACTR5 Gene

SOURCE GeneReport for Unigene cluster for ACTR5 Gene Hs.371585

genes like me logo Genes that share expressions with ACTR5: view

Expression partners for ACTR5 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ACTR5 Gene

Orthologs for ACTR5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ACTR5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ACTR5 35
  • 87.97 (n)
  • 92.42 (a)
ACTR5 36
  • 92 (a)
(Canis familiaris)
Mammalia ACTR5 35
  • 90.34 (n)
  • 93.71 (a)
ACTR5 36
  • 91 (a)
(Mus musculus)
Mammalia Actr5 35
  • 85.14 (n)
  • 90.17 (a)
Actr5 16
Actr5 36
  • 89 (a)
(Pan troglodytes)
Mammalia ACTR5 35
  • 99.51 (n)
  • 99.51 (a)
ACTR5 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Actr5 35
  • 84.25 (n)
  • 92.68 (a)
(Monodelphis domestica)
Mammalia ACTR5 36
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 72 (a)
-- 36
  • 83 (a)
(Gallus gallus)
Aves ACTR5 35
  • 75.85 (n)
  • 79.93 (a)
ACTR5 36
  • 79 (a)
(Anolis carolinensis)
Reptilia ACTR5 36
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia actr5 35
  • 67.9 (n)
  • 70.14 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16529 35
(Danio rerio)
Actinopterygii actr5 35
  • 62.53 (n)
  • 59.89 (a)
Dr.26688 35
actr5 36
  • 56 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004488 35
  • 50.45 (n)
  • 45.4 (a)
fruit fly
(Drosophila melanogaster)
Insecta Arp5 35
  • 51.69 (n)
  • 42.35 (a)
Arp5 36
  • 33 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL253C 35
  • 47.9 (n)
  • 37.4 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F03421g 35
  • 44.4 (n)
  • 35.55 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARP5 35
  • 44.51 (n)
  • 33.52 (a)
ARP5 36
  • 24 (a)
ARP5 38
thale cress
(Arabidopsis thaliana)
eudicotyledons ARP5 35
  • 49.21 (n)
  • 40.15 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06394 35
  • 46.97 (n)
  • 37.83 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes arp5 35
  • 46.14 (n)
  • 39.43 (a)
Species with no ortholog for ACTR5:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ACTR5 Gene

Gene Tree for ACTR5 (if available)
Gene Tree for ACTR5 (if available)

Paralogs for ACTR5 Gene

No data available for Paralogs for ACTR5 Gene

Variants for ACTR5 Gene

Sequence variations from dbSNP and Humsavar for ACTR5 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs911720 -- 38,771,299(-) AGTGG(C/T)TCAGC intron-variant
rs911721 -- 38,771,231(-) GGCCC(A/C/G)TGACC intron-variant
rs911722 -- 38,770,882(-) AGGTT(A/G)GAATG intron-variant
rs1406855 -- 38,753,942(-) ACCAC(G/T)AAAAA intron-variant
rs1406856 -- 38,753,759(-) AAAAC(C/T)AATTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ACTR5 Gene

Variant ID Type Subtype PubMed ID
dgv4568n71 CNV Loss 21882294

Relevant External Links for ACTR5 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACTR5 Gene

Disorders for ACTR5 Gene

Relevant External Links for ACTR5

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for ACTR5 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for ACTR5 Gene

Publications for ACTR5 Gene

  1. A mammalian chromatin remodeling complex with similarities to the yeast INO80 complex. (PMID: 16230350) Jin J. … Conaway J.W. (J. Biol. Chem. 2005) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Subunit organization of the human INO80 chromatin remodeling complex: An evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling. (PMID: 21303910) Chen L. … Conaway R.C. (J. Biol. Chem. 2011) 3 4
  5. INO80 chromatin remodeling complex promotes the removal of UV lesions by the nucleotide excision repair pathway. (PMID: 20855601) Jiang Y. … Li L. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3 4

Products for ACTR5 Gene

Sources for ACTR5 Gene

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