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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ACTR5 Gene

protein-coding   GIFtS: 48
GCID: GC20P037377

ARP5 actin-related protein 5 homolog (yeast)

(Previous names: ARP5 (actin-related protein 5, yeast) homolog )
 Explore 2 diseases affiliated with
ACTR5 via our new
 Human Malady Compendium 
Biological research products
for ACTR5
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
ARP5 Actin-Related Protein 5 Homolog (Yeast)1 2     FLJ127851
Arp51 2     ARP5 (Actin-Related Protein 5, Yeast) Homolog1
INO80M1 2     Actin-Related Protein 52
Sarcoma Antigen NY-SAR-162 3     INO80 Complex Subunit M2
HARP51     ARP53

External Ids:    HGNC: 146711   Entrez Gene: 799132   Ensembl: ENSG000001014427   UniProtKB: Q9H9F93   

Export aliases for ACTR5 gene to outside databases

Previous GC identifers: GC00U991039 GC20P038063 GC20P036810 GC20P034114


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ARP5_HUMAN, Q9H9F9
Function: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional
regulation, DNA replication and probably DNA repair. Involved in DNA double-strand break repair and UV-damage excision
repair




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.1  NT_011362.10  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ACTR5 gene promoter:
         AhR   AML1a   p53   Tal-1beta   LCR-F1   E47   Arnt   Max   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidACTR5 promoter sequence
   Search SABiosciences Chromatin IP Primers for ACTR5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ACTR5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q11.23   Ensembl cytogenetic band:  20q11.23   HGNC cytogenetic band: 20q12

ACTR5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ACTR5 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P037377:  view genomic region     (about GC identifiers)

Start:
37,377,085 bp from pter      End:
37,401,089 bp from pter
Size:
24,005 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ARP5_HUMAN, Q9H9F9 (See protein sequence)
Recommended Name: Actin-related protein 5  
Size: 607 amino acids; 68297 Da
Subunit: Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the
helicase ATP-binding and the helicase C-terminal domain of INO80. Interacts with DDB1. Interacts with ACTR8; the
interaction is observed in asynchronous (interphase) cells but not in metaphase-arrested cells indicative for a
possible dissociation of the INO80 complex in mitotic cells
Subcellular location: Nucleus. Cytoplasm. Note=Predominantly nuclear but undergoes nucleo-cytoplasmic shuttling.
Localized to interphase nuclei, but not nucleoli; excluded from chromosomes as mitosis progresses
Sequence caution: Sequence=AAO65164.1; Type=Frameshift; Positions=319, 343, 347;
Secondary accessions: Q86WF7 Q8IUY5 Q8N724 Q9BRN0 Q9BVB7

Explore the universe of human proteins at neXtProt for ACTR5: NX_Q9H9F9

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9H9F9

  • ACTR5 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_079131.3  
    ENSEMBL proteins: 
     ENSP00000243903  

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    Uscn Proteins for ACTR5

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA19014934
    GO:0005737cytoplasm IDA19014934
    GO:0031011Ino80 complex IDA--


    ACTR5 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ACTR5 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR004001 Actin_CS
     IPR004000 Actin-related

    Graphical View of Domain Structure for InterPro Entry Q9H9F9

    ProtoNet protein and cluster: Q9H9F9

    1 Blocks protein family: IPB004000 Actin/actin-like

    UniProtKB/Swiss-Prot: ARP5_HUMAN, Q9H9F9
    Similarity: Belongs to the actin family. ARP5 subfamily


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: ARP5_HUMAN, Q9H9F9
    Function: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional
    regulation, DNA replication and probably DNA repair. Involved in DNA double-strand break repair and UV-damage excision
    repair

    miRNA
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    Inhib. RNA
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IEA--


    ACTR5 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for ACTR5:
     Increased cilium length after  


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ACTR5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    5/43 Interacting proteins for ACTR5 (Q9H9F91, 2, 3 ENSP000002439034) via UniProtKB, MINT, STRING, and/or I2D (see all 43)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CSNK2BP678702, 3MINT-8252978 I2D: score=2 
    HIST1H2BCP628073I2D: score=1 
    HIST1H2BEP628073I2D: score=1 
    HIST1H2BFP628073I2D: score=1 
    HIST1H2BGP628073I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006302double-strand break repair IMP19014934
    GO:0006310DNA recombination IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0070914UV-damage excision repair IMP--


    ACTR5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ACTR5
    Search CenterWatch for drugs/clinical trials and news about ACTR5 / ARP5 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ACTR5 gene: 
    NM_024855.3  

    Unigene Cluster for ACTR5:

    ARP5 actin-related protein 5 homolog (yeast)
    Hs.371585  [show with all ESTs]
    Unigene Representative Sequence: NM_024855
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000243903(uc002xjd.2)

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    Additional cDNA sequence: 

    AK022847.1 AY211911.1 BC001324.1 BC006162.1 BC038402.1 

    6 DOTS entries:

    DT.426494  DT.95270331  DT.120824094  DT.40128069  DT.40298223  DT.92423486 

    24/72 AceView cDNA sequences (see all 72):

    BU786446 CA495366 BC001324 AA223739 BM905758 AK022847 BM996036 BE382642 
    AA604593 BG576224 CD369756 BF206386 BI752445 BG766433 BC006162 AI950010 
    BU951426 AA171724 AA171820 AI862334 BG424997 BU509657 BE743210 BE900629 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for ACTR5    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
    SP1:                                                                  
    SP2:                                                                  


    ECgene alternative splicing isoforms for ACTR5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ACTR5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCTTGGGCCA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See ACTR5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ACTR5

    SOURCE GeneReport for Unigene cluster: Hs.371585
        SABiosciences Custom PCR Arrays for ACTR5
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACTR5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ACTR5 gene from 8/30 species (see all 30)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves ACTR51 ARP5 actin-related protein 5 homolog (yeast) 75.76(n)
    79.5(a)
      419169  NM_001008446.1  NP_001008446.1 
    lizard
    (Anolis carolinensis)
    Reptilia ACTR56
    --
    76(a)
    1 ↔ 1
    4(141139097-141151960)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.165292 Xenopus laevis transcribed sequence with weak similarity more 72.2(n)    CD363093.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.266882 Danio rerio cDNA clone MGC63743 IMAGE2640067, complete more 74.97(n)    BC055228.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Arp51 Actin-related protein 5 50.25(n)
    41.6(a)
      42173  NM_142427.3  NP_650684.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ARP5(YNL059C)4
    ARP51
    Nuclear actin-related protein involved in chromatin more4
    Arp5p1
    43.08(n)1
    31.33(a)1
      14(514935-512668)4
    8556651, 4  NP_014339.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ARP51 actin-related protein 5 46.89(n)
    36.38(a)
      820416  NM_001202941.1  NP_001189870.1 
    rice
    (Oryza sativa)
    Liliopsida --
    actin, putative, expressed
    15(a)
    possible ortholog
    3(32437237-32441779)


    ENSEMBL Gene Tree for ACTR5 (if available)
    TreeFam Gene Tree for ACTR5 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/519 NCBI SNPs in ACTR5 are shown (see all 519    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1884330341,2
    --37375108(+) CACTGA/CAACCT 1 -- us2k10--------
    rs27486581,2
    C,A,--37375140(+) ttctcC/Ttgcct 1 -- us2k12Minor allele frequency- T:0.33NA CSA 3
    rs27486591,2
    C,A,--37375155(+) CTCCCG/AAGTAG 1 -- us2k12Minor allele frequency- A:0.33NA CSA 3
    rs27575171,2
    C,F,A,--37375385(+) ACTAAC/TTTACA 1 -- us2k16Minor allele frequency- T:0.34NA CSA WA EA 364
    rs27486601,2
    C,A,--37375392(+) TACATT/CTACTG 1 -- us2k1 tfbs33Minor allele frequency- C:0.29NA EA 242
    rs60277261,2
    C,F,A,H,--37375444(+) ATGGTT/AACTTC 1 -- us2k17Minor allele frequency- A:0.25NS EA NA 660
    rs60277271,2
    C,F,A,H,--37375469(+) TGGACG/TTGTGT 1 -- us2k117Minor allele frequency- T:0.33NS EA NA WA 2324
    rs622024631,2
    C,F,--37375638(+) GCCAAC/GGTGGC 1 -- us2k14Minor allele frequency- G:0.12NA CSA EA 244
    rs573267071,2
    C,F,--37375651(+) AATCCC/TGTCTG 1 -- us2k11Minor allele frequency- T:0.03NA 120
    rs1907765381,2
    --37375879(+) GATAAA/GTTAGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ACTR5 (37377085 - 37401089 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ACTR5: --

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ACTR5 for disorders           About GeneDecksing

    2 diseases for ACTR5:    About MalaCards
    sarcoma    malaria

    Human Genome Epidemiology (HuGE) Navigator: ACTR5 (1 document)

    Export disorders for ACTR5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ACTR5 gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with ACTR5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A mammalian chromatin remodeling complex with similarities to the yeast INO80 complex. (PubMed id 16230350)1, 2, 3 Jin J.... Conaway J.W. (2005)
    2. Subunit organization of the human INO80 chromatin remodeling complex: An evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling. (PubMed id 21303910)1, 2 Chen L.... Conaway R.C. (2011)
    3. The human actin-related protein hArp5: nucleo-cytoplasmic shuttling and involvement in DNA repair. (PubMed id 19014934)1, 2 Kitayama K....Harata M. (2009)
    4. Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin-remodeling complex. (PubMed id 18922472)1, 2 Yao T....Conaway J.W. (2008)
    5. The actin-related protein hArp8 accumulates on the mitotic chromosomes and functions in chromosome alignment. (PubMed id 18163988)1, 2 Aoyama N....Harata M. (2008)
    6. A YY1-INO80 complex regulates genomic stability through homologous recombination-based repair. (PubMed id 18026119)1, 2 Wu S.... Shi Y. (2007)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    9. Immunomic analysis of human sarcoma. (PubMed id 12601173)1, 2 Lee S.-Y.... Scanlan M.J. (2003)
    10. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79913 HGNC: 14671 AceView: ACTR5 Ensembl:ENSG00000101442 euGenes: HUgn79913
    ECgene: ACTR5 H-InvDB: ACTR5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ACTR5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ACTR5 gene:
    Search GeneIP for patents involving ACTR5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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