ACTR3C Gene
protein-coding GIFtS: 36
GCID: GC07M149942
|
|
ARP3 actin-related protein 3 homolog C (yeast)
| |
Aliases
for ACTR3C gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| ARP3 Actin-Related Protein 3 Homolog C (Yeast)1 2 | | ARP111 2 3 | | Actin-Related Protein 112 3 | | Actin-Related Arp112 | | Actin-Related Protein 3C2 |
Export aliases for ACTR3C gene to outside databasesPrevious GC identifers: GC07M149577 GC07M143760 |
Summaries
for ACTR3C gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ARP3C_HUMAN, Q9C0K3Function: May play a role in the suppression of metastatic potential in lung adenoma carcinoma cells
|
Genomic Views
for ACTR3C gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007914.15 NT_079596.2
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for ACTR3C
Other transcription factors
Search SABiosciences Chromatin IP Primers for ACTR3C
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ACTR3C |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q36.1 Ensembl cytogenetic band: 7q36.1 HGNC cytogenetic band: 7q36.1ACTR3C Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07M149942: view genomic region
(about GC identifiers)
Start:
|
149,941,005 bp from pter |
End:
|
150,020,814 bp from pter |
Size:
|
79,810 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr7-,CRA_TCAG 149,282,168-149,358,608 |
|
Proteins
for ACTR3C gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ARP3C_HUMAN, Q9C0K3 (See
protein sequence)Recommended Name: Actin-related protein 3C precursor Size: 210 amino acids; 23712 Da
Secondary accessions: Q5CZI4Alternative splicing: 2 isoforms: Q9C0K3-1 Q9C0K3-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for ACTR3C: NX_Q9C0K3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9C0K3
ACTR3C Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001157930.1 NP_001157931.1
ENSEMBL proteins: ENSP00000417426 ENSP00000252071 ENSP00000418635 ENSP00000417997 ENSP00000440990
Human Recombinant Protein Products for ACTR3C:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005856 | cytoskeleton |
IEA | -- |
ACTR3C for ontologies About GeneDecksing
ACTR3C Antibody Products:
Assay Products for ACTR3C: |
Protein
Domains /
Families
for ACTR3C gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ACTR3C for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9C0K3ProtoNet protein and cluster: Q9C0K3 UniProtKB/Swiss-Prot: ARP3C_HUMAN, Q9C0K3Similarity: Belongs to the actin family |
Function
for ACTR3C gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: ARP3C_HUMAN, Q9C0K3Function: May play a role in the suppression of metastatic potential in lung adenoma carcinoma cells Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
ACTR3C for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ACTR3C (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ACTR3C (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): ACTR3C (NM_001164458) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ACTR3C | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ACTR3C |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACTR3C |
|
Pathways & Interactions
for ACTR3C gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ACTR3C
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0030833 | regulation of actin filament polymerization |
IEA | -- |
ACTR3C for ontologies About GeneDecksing
|
Drugs & Compounds
for ACTR3C gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ACTR3C
Search CenterWatch for drugs/clinical trials and news about ACTR3C / ARP3C
|
Transcripts
for ACTR3C gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ACTR3C gene (2 alternative transcripts): NM_001164458.1 NM_001164459.1 Unigene Cluster for ACTR3C: ARP3 actin-related protein 3 homolog C (yeast) Hs.664579 [show with all ESTs]Unigene Representative Sequence: BX6406435 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000478393 ENST00000252071(uc003wgu.2) ENST00000477871 ENST00000477367
ENST00000539352(uc022aps.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ACTR3C (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ACTR3C (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): ACTR3C (NM_001164458) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ACTR3C | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ACTR3C |
Additional cDNA sequence: AB039791.1 AK127403.1 AK130039.1 BX640643.1 6 DOTS entries: DT.40192049 DT.40246551 DT.97768839 DT.100663830 DT.121069929 DT.121090397
GeneLoc Exon Structure
|
Expression
for ACTR3C gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ACTR3C expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTCTTGGAGA
About this image
See ACTR3C Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ACTR3C
SOURCE GeneReport for Unigene cluster: Hs.664579
UniProtKB/Swiss-Prot: ARP3C_HUMAN, Q9C0K3Tissue specificity: Expressed in kidney, stomach, spleen, bone marrow, uterus, testis, placenta, skeletal muscle,mammary gland, lung, fetal liver, and fetal kidney, but not detected in small intestine, brain, and thymus. Expressedin low-metastatic lung adenocarcinoma cells but not in high-metastatic ones
SABiosciences Custom PCR Arrays for ACTR3C
Primer
Products: | | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ACTR3C | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ACTR3C | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ACTR3C | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACTR3C |
Orthologs
for ACTR3C gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for ACTR3C gene from 7/23 species (see all 23) About this table
ENSEMBL Gene Tree for ACTR3C (if available)
TreeFam Gene Tree for ACTR3C (if available) |
Paralogs
for ACTR3C gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ACTR3C gene
- ACTR32 ACTR102 ACTR3B2
18/19 SIMAP similar genes for ACTR3C using alignment to 4 protein entries: ARP3C_HUMAN (see all proteins)
(see all similar genes):ACTR3B ACTR3 FKSG72 FKSG73 FKSG74 ACTB
ACT ACTG1 ACTR1A ACTA1 ACTC1 ACTR2
ACTA2 ACTBL2 POTEF POTEI POTEJ POTEE
ACTR3C for paralogs About GeneDecksing
|
Genomic Variants
for ACTR3C gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ACTR3C (149941005 - 150020814 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for ACTR3C
4 CNVs: 3709 52151 82262 82261 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for ACTR3C gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ACTR3C for disorders About GeneDecksing
5  diseases for ACTR3C: About MalaCardslung adenoma lung adenocarcinoma adenoma adenocarcinoma
carcinoma
Export disorders for ACTR3C gene to outside databases
|
Publications
for ACTR3C gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ACTR3C gene integrated from 9 sources:
(articles sorted by number of sources associating them with ACTR3C) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Isolation of a novel actin-related gene expressed in low-metastatic PC-14 human lung adenocarcinoma. (PubMed id 11162478)1, 2, 3 Shindo-Okada N. and Shimizu K. (2001)
- Expression of the Arp11 gene suppresses the tumorigenicity of PC-14 human lung adenocarcinoma cells. (PubMed id 14651955)1, 3 Shindo-Okada N. and Iigo M. (2003)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)
|
External Searches for ACTR3C gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ACTR3C gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ACTR3C gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ACTR3C gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ACTR3C | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ACTR3C gene:
Search GeneIP for patents involving ACTR3C
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ACTR3C gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 |
| | | | |
 |
 |
|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ACTR3C | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ACTR3C | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ACTR3C | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ACTR3C | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ACTR3C | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ACTR3C |
| |
 |  |  |  | |
| | | | Search Tocris compounds for ACTR3C |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | ACTR3C Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACTR3C |
|  |  |  |  | | | | Search ThermoFisher Antibodies for ACTR3C |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ACTR3C |
| |  | |
|
|
|
