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Aliases for ACTR3C Gene

Aliases for ACTR3C Gene

  • ARP3 Actin-Related Protein 3 Homolog C (Yeast) 2 3
  • Actin-Related Protein 11 3 4
  • Arp11 3 4
  • Actin-Related Protein 3C 3
  • Actin-Related Arp11 3

External Ids for ACTR3C Gene

Previous GeneCards Identifiers for ACTR3C Gene

  • GC07M149577
  • GC07M149942
  • GC07M143760

Summaries for ACTR3C Gene

GeneCards Summary for ACTR3C Gene

ACTR3C (ARP3 Actin-Related Protein 3 Homolog C (Yeast)) is a Protein Coding gene. Diseases associated with ACTR3C include lung adenoma. GO annotations related to this gene include actin binding. An important paralog of this gene is ACTR3B.

UniProtKB/Swiss-Prot for ACTR3C Gene

  • May play a role in the suppression of metastatic potential in lung adenoma carcinoma cells.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACTR3C Gene

Genomics for ACTR3C Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ACTR3C Gene

150,243,916 bp from pter
150,323,725 bp from pter
79,810 bases
Minus strand

Genomic View for ACTR3C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ACTR3C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACTR3C Gene

No data available for Regulatory Elements for ACTR3C Gene

Proteins for ACTR3C Gene

  • Protein details for ACTR3C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Actin-related protein 3C
    Protein Accession:
    Secondary Accessions:
    • Q5CZI4

    Protein attributes for ACTR3C Gene

    210 amino acids
    Molecular mass:
    23712 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ACTR3C Gene


neXtProt entry for ACTR3C Gene

Proteomics data for ACTR3C Gene at MOPED

Post-translational modifications for ACTR3C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ACTR3C Gene

No data available for DME Specific Peptides for ACTR3C Gene

Domains for ACTR3C Gene

Protein Domains for ACTR3C Gene


Suggested Antigen Peptide Sequences for ACTR3C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9C0K3
  • Belongs to the actin family.
genes like me logo Genes that share domains with ACTR3C: view

No data available for Gene Families for ACTR3C Gene

Function for ACTR3C Gene

Molecular function for ACTR3C Gene

UniProtKB/Swiss-Prot Function:
May play a role in the suppression of metastatic potential in lung adenoma carcinoma cells.

Gene Ontology (GO) - Molecular Function for ACTR3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003779 actin binding IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with ACTR3C: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ACTR3C Gene

Localization for ACTR3C Gene

Subcellular locations from

Jensen Localization Image for ACTR3C Gene COMPARTMENTS Subcellular localization image for ACTR3C gene
Compartment Confidence
cytoskeleton 2
cytosol 2
extracellular 2
endoplasmic reticulum 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ACTR3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005885 Arp2/3 protein complex IEA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with ACTR3C: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ACTR3C Gene

Pathways for ACTR3C Gene

SuperPathways for ACTR3C Gene

No Data Available

Interacting Proteins for ACTR3C Gene

Gene Ontology (GO) - Biological Process for ACTR3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0034314 Arp2/3 complex-mediated actin nucleation IEA --
genes like me logo Genes that share ontologies with ACTR3C: view

No data available for Pathways by source for ACTR3C Gene

Transcripts for ACTR3C Gene

mRNA/cDNA for ACTR3C Gene

(16) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ACTR3C Gene

ARP3 actin-related protein 3 homolog C (yeast):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ACTR3C

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ACTR3C Gene

No ASD Table

Relevant External Links for ACTR3C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ACTR3C Gene

mRNA expression in normal human tissues for ACTR3C Gene

mRNA differential expression in normal tissues according to GTEx for ACTR3C Gene

This gene is overexpressed in Liver (8.5).

Protein differential expression in normal tissues for ACTR3C Gene

This gene is overexpressed in Skin (43.4) and Brain (25.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ACTR3C Gene

SOURCE GeneReport for Unigene cluster for ACTR3C Gene Hs.664579

mRNA Expression by UniProt/SwissProt for ACTR3C Gene

Tissue specificity: Expressed in kidney, stomach, spleen, bone marrow, uterus, testis, placenta, skeletal muscle, mammary gland, lung, fetal liver, and fetal kidney, but not detected in small intestine, brain, and thymus. Expressed in low-metastatic lung adenocarcinoma cells but not in high-metastatic ones.
genes like me logo Genes that share expressions with ACTR3C: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for ACTR3C Gene

Orthologs for ACTR3C Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ACTR3C Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia -- 36
  • 45 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 45 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 44 (a)
(Gallus gallus)
Aves -- 36
  • 44 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 39 (a)
(Danio rerio)
Actinopterygii actr3b 36
  • 40 (a)
fruit fly
(Drosophila melanogaster)
Insecta Arp66B 36
  • 37 (a)
(Caenorhabditis elegans)
Secernentea arx-1 36
  • 33 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARP3 36
  • 28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 46 (a)
Species with no ortholog for ACTR3C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ACTR3C Gene

Gene Tree for ACTR3C (if available)
Gene Tree for ACTR3C (if available)

Paralogs for ACTR3C Gene

Paralogs for ACTR3C Gene

Selected SIMAP similar genes for ACTR3C Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ACTR3C: view

Variants for ACTR3C Gene

Sequence variations from dbSNP and Humsavar for ACTR3C Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs1317579 -- 150,272,863(-) aaatt(A/T)aaaaa intron-variant
rs1976868 -- 150,272,843(+) atcca(A/C)cacat intron-variant
rs1976869 -- 150,272,846(+) caaca(C/T)atcca intron-variant
rs1976875 -- 150,270,998(-) TGTGT(G/T)CTGCT intron-variant
rs2108853 -- 150,320,500(-) CAGGC(G/T)TGAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ACTR3C Gene

Variant ID Type Subtype PubMed ID
dgv2151e1 CNV Complex 17122850
nsv889435 CNV Gain 21882294
nsv889452 CNV Gain 21882294
nsv508490 CNV Loss 20534489
dgv7541n71 CNV Loss 21882294
dgv435n21 CNV Loss 19592680
nsv521407 CNV Loss 19592680

Relevant External Links for ACTR3C Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACTR3C Gene

Disorders for ACTR3C Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for ACTR3C Gene in MalaCards »

(1) Diseases for ACTR3C Gene including...

genes like me logo Genes that share disorders with ACTR3C: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for ACTR3C Gene

Publications for ACTR3C Gene

  1. Isolation of a novel actin-related gene expressed in low-metastatic PC-14 human lung adenocarcinoma. (PMID: 11162478) Shindo-Okada N. … Shimizu K. (Biochem. Biophys. Res. Commun. 2001) 2 3 4
  2. Expression of the Arp11 gene suppresses the tumorigenicity of PC-14 human lung adenocarcinoma cells. (PMID: 14651955) Shindo-Okada N. … Iigo M. (Biochem. Biophys. Res. Commun. 2003) 2 3
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S. … Drake R.R. (Proteomics 2013) 3
  5. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4

Products for ACTR3C Gene

Sources for ACTR3C Gene

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