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ACTR3C Gene

protein-coding   GIFtS: 35
GCID: GC07M149942

ARP3 Actin-Related Protein 3 Homolog C (Yeast)

  See ACTR3C-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ARP3 Actin-Related Protein 3 Homolog C (Yeast)1 2
Actin-Related Protein 112 3
ARP112 3
Actin-Related Arp112
Actin-Related Protein 3C2

External Ids:    HGNC: 372821   Entrez Gene: 6538572   Ensembl: ENSG000001065267   UniProtKB: Q9C0K33   

Export aliases for ACTR3C gene to outside databases

Previous GC identifers: GC07M149577 GC07M143760


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ACTR3C Gene:
ACTR3C (ARP3 actin-related protein 3 homolog C (yeast)) is a protein-coding gene. Diseases associated with ACTR3C include lung adenoma. GO annotations related to this gene include actin binding. An important paralog of this gene is ACTR3.

UniProtKB/Swiss-Prot: ARP3C_HUMAN, Q9C0K3
Function: May play a role in the suppression of metastatic potential in lung adenoma carcinoma cells




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NT_007933.16  NC_018918.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for ACTR3C
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for ACTR3C

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ACTR3C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q36.1   Ensembl cytogenetic band:  7q36.1   HGNC cytogenetic band: 7q36.1

ACTR3C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ACTR3C gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M149942:  view genomic region     (about GC identifiers)

Start:
149,941,005 bp from pter      End:
150,020,814 bp from pter
Size:
79,810 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 149,282,168-149,358,608     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ARP3C_HUMAN, Q9C0K3 (See protein sequence)
Recommended Name: Actin-related protein 3C precursor  
Size: 210 amino acids; 23712 Da
Secondary accessions: Q5CZI4
Alternative splicing: 2 isoforms:  Q9C0K3-1   Q9C0K3-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ACTR3C: NX_Q9C0K3

Explore proteomics data for ACTR3C at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ACTR3C Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001157930.1  NP_001157931.1  

    ENSEMBL proteins: 
     ENSP00000417426   ENSP00000252071   ENSP00000418635   ENSP00000417997   ENSP00000440990  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR015623 Arp3
     IPR004000 Actin-related

    Graphical View of Domain Structure for InterPro Entry Q9C0K3

    ProtoNet protein and cluster: Q9C0K3

    UniProtKB/Swiss-Prot: ARP3C_HUMAN, Q9C0K3
    Similarity: Belongs to the actin family


    Find genes that share domains with ACTR3C           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ARP3C_HUMAN, Q9C0K3
    Function: May play a role in the suppression of metastatic potential in lung adenoma carcinoma cells

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0005524ATP binding IEA--
         
    Find genes that share ontologies with ACTR3C           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ACTR3C

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    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton2
    cytosol2
    extracellular2
    endoplasmic reticulum1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005885Arp2/3 protein complex ----

    Find genes that share ontologies with ACTR3C           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ACTR3C
    Interactions:

        Search GeneGlobe Interaction Network for ACTR3C

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ACTR3C (ENSP000002520714) via UniProtKB, MINT, STRING, and/or I2D (see all 85)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACTR6ENSP000001883124STRING: ENSP00000188312
    PFN4ENSP000003221704STRING: ENSP00000322170
    GMFBENSP000003507574STRING: ENSP00000350757
    MCM4ENSP000002621054STRING: ENSP00000262105
    CFL2ENSP000002981594STRING: ENSP00000298159
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0034314Arp2/3 complex-mediated actin nucleation ----

    Find genes that share ontologies with ACTR3C           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ACTR3C (ARP3C)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ACTR3C gene (2 alternative transcripts): 
    NM_001164458.1  NM_001164459.1  

    Unigene Cluster for ACTR3C:

    ARP3 actin-related protein 3 homolog C (yeast)
    Hs.664579  [show with all ESTs]
    Unigene Representative Sequence: BX640643
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000478393 ENST00000252071(uc003wgu.2) ENST00000477871 ENST00000477367
    ENST00000539352(uc022aps.1)
    miRNA
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    hsa-miR-30c hsa-miR-642a hsa-miR-30a hsa-miR-30b hsa-miR-30d hsa-miR-30e
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Additional mRNA sequence: 

    AB039791.1 AK127403.1 AK130039.1 BX640643.1 

    6 DOTS entries:

    DT.40192049  DT.40246551  DT.97768839  DT.100663830  DT.121069929  DT.121090397 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ACTR3C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCTTGGAGA
    ACTR3C Expression
    About this image

    ACTR3C Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ACTR3C Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.664579

    UniProtKB/Swiss-Prot: ARP3C_HUMAN, Q9C0K3
    Tissue specificity: Expressed in kidney, stomach, spleen, bone marrow, uterus, testis, placenta, skeletal muscle,
    mammary gland, lung, fetal liver, and fetal kidney, but not detected in small intestine, brain, and thymus.
    Expressed in low-metastatic lung adenocarcinoma cells but not in high-metastatic ones

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACTR3C

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ACTR3C gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    oppossum
    (Monodelphis domestica)
    Mammalia --
    --
    45(a)
    1 → many
    8(217978810-218105665)
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    44(a)
    1 → many
    2(6790127-6814661)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    39(a)
    1 → many
    6(4522009-4550009)
    zebrafish
    (Danio rerio)
    Actinopterygii actr3b6
    ARP3 actin-related protein 3 homolog B (yeast)
    40(a)
    1 → many
    24(7408318-7435323) ENSDARG00000008790
    fruit fly
    (Drosophila melanogaster)
    Insecta Arp66B6
    Actin-related protein 66B
    37(a)
    1 → many
    3L(8106507-8109002)
    worm
    (Caenorhabditis elegans)
    Secernentea arx-16
    Protein ARX-1 (arx-1) mRNA, complete cds
    33(a)
    1 → many
    I(2883496-2893718) WBGene00000199
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ARP36
    Essential component of the Arp2/3 complex, which i...
    28(a)
    1 → many
    X(557809-559158) YJR065C


    ENSEMBL Gene Tree for ACTR3C (if available)
    TreeFam Gene Tree for ACTR3C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ACTR3C gene
    ACTR32  ACTR3B2  
    Selected SIMAP similar genes for ACTR3C using alignment to 4 protein entries:     ARP3C_HUMAN (see all proteins) (see all similar genes):
    ACTR3B    ACTR3    FKSG72    FKSG73    FKSG74    ACTB
    ACT    ACTG1    POTEM    ACTR1A    ACTA1    ACTC1
    ACTR2    ACTA2    ACTBL2    POTEF    POTEI    POTEJ

    Find genes that share paralogs with ACTR3C           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ACTR3C (see all 1547)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs38324911,2
    C--143801531(-) TTGAGG/-CCAGG 2 -- int11Minor allele frequency- -:0.00NA 2
    rs1851400931,2
    --149339921(+) CTGCCC/TGGGCT 1 -- us2k10--------
    rs625026411,2
    --149943841(+) AAATAC/TCACAA 2 -- int10--------
    rs1125610191,2
    C--149943870(+) TGGCTTTTTG/
            
    TTTTG
    2 -- int11Minor allele frequency- -:0.50CSA 2
    rs1411555641,2
    --149943943(+) ATGGCA/GTGATC 2 -- int10--------
    rs1850856911,2
    --149944043(+) CACCCA/GGTTAA 2 -- int10--------
    rs104292401,2
    C--149944073(+) aaagaC/Tggggt 2 -- int10--------
    rs1884042401,2
    --149944131(+) CTGCCC/TGCCTC 2 -- int10--------
    rs776996031,2
    C--149944152(+) AGTGCC/TGGGAT 2 -- int10--------
    rs1437736611,2
    C--149944478(+) CCCCAC/TGTAGT 2 -- ut310--------

    HapMap Linkage Disequilibrium report for ACTR3C (149941005 - 150020814 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for ACTR3C:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv435n21CNV Loss19592680
    nsv508490CNV Loss20534489
    nsv521407CNV Loss19592680
    dgv7541n71CNV Loss21882294
    nsv889452CNV Gain21882294
    nsv889435CNV Gain21882294
    dgv2151e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): ACTR3C
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing ACTR3C
    DNA2.0 Custom Variant and Variant Library Synthesis for ACTR3C

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for ACTR3C:    
    About MalaCards
    lung adenoma


    Find genes that share disorders with ACTR3C           About GenesLikeMe


    Export disorders for ACTR3C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ACTR3C gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ACTR3C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of a novel actin-related gene expressed in low-metastatic PC-14 human lung adenocarcinoma. (PubMed id 11162478)1, 2, 3 Shindo-Okada N. and Shimizu K. (Biochem. Biophys. Res. Commun. 2001)
    2. Expression of the Arp11 gene suppresses the tumorigenicity of PC-14 human lung adenocarcinoma cells. (PubMed id 14651955)1, 3 Shindo-Okada N. and Iigo M. (Biochem. Biophys. Res. Commun. 2003)
    3. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    5. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (Genome Res. 1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 653857 HGNC: 37282 Ensembl:ENSG00000106526 euGenes: HUgn653857 ECgene: ACTR3C
    H-InvDB: ACTR3C

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ACTR3C Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ACTR3C gene:
    Search GeneIP for patents involving ACTR3C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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     Block miRNA regulation of human, mouse, rat ACTR3C using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ACTR3C
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