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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ACTR3C Gene

protein-coding   GIFtS: 35
GCID: GC07M149942

ARP3 Actin-Related Protein 3 Homolog C (Yeast)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
ARP3 Actin-Related Protein 3 Homolog C (Yeast)1 2
Actin-Related Protein 112 3
ARP112 3
Actin-Related Arp112
Actin-Related Protein 3C2

External Ids:    HGNC: 372821   Entrez Gene: 6538572   Ensembl: ENSG000001065267   UniProtKB: Q9C0K33   

Export aliases for ACTR3C gene to outside databases

Previous GC identifers: GC07M149577 GC07M143760


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ACTR3C Gene: 
ACTR3C (ARP3 actin-related protein 3 homolog C (yeast)) is a protein-coding gene. Diseases associated with ACTR3C include lung adenoma, and lung adenocarcinoma. GO annotations related to this gene include actin binding and ATP binding. An important paralog of this gene is ACTR3.

UniProtKB/Swiss-Prot: ARP3C_HUMAN, Q9C0K3
Function: May play a role in the suppression of metastatic potential in lung adenoma carcinoma cells




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_007914.15  NC_018918.2  NT_079596.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for ACTR3C
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for ACTR3C

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ACTR3C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q36.1   Ensembl cytogenetic band:  7q36.1   HGNC cytogenetic band: 7q36.1

ACTR3C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ACTR3C gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M149942:  view genomic region     (about GC identifiers)

Start:
149,941,005 bp from pter      End:
150,020,814 bp from pter
Size:
79,810 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 149,282,168-149,358,608     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ARP3C_HUMAN, Q9C0K3 (See protein sequence)
Recommended Name: Actin-related protein 3C precursor  
Size: 210 amino acids; 23712 Da
Secondary accessions: Q5CZI4
Alternative splicing: 2 isoforms:  Q9C0K3-1   Q9C0K3-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ACTR3C: NX_Q9C0K3

Explore proteomics data for ACTR3C at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9C0K3

  • ACTR3C Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ACTR3C Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001157930.1  NP_001157931.1  

    ENSEMBL proteins: 
     ENSP00000417426   ENSP00000252071   ENSP00000418635   ENSP00000417997   ENSP00000440990  

    Human Recombinant Protein Products for ACTR3C: 
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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005885Arp2/3 protein complex IEA--

    ACTR3C for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR015623 Arp3
     IPR004000 Actin-related

    Graphical View of Domain Structure for InterPro Entry Q9C0K3

    ProtoNet protein and cluster: Q9C0K3

    UniProtKB/Swiss-Prot: ARP3C_HUMAN, Q9C0K3
    Similarity: Belongs to the actin family


    ACTR3C for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ARP3C_HUMAN, Q9C0K3
    Function: May play a role in the suppression of metastatic potential in lung adenoma carcinoma cells

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0005524ATP binding IEA--
         
    ACTR3C for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ACTR3C

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0034314Arp2/3 complex-mediated actin nucleation IEA--

    ACTR3C for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Search CenterWatch for drugs/clinical trials and news about ACTR3C / ARP3C

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for ACTR3C gene (2 alternative transcripts): 
    NM_001164458.1  NM_001164459.1  

    Unigene Cluster for ACTR3C:

    ARP3 actin-related protein 3 homolog C (yeast)
    Hs.664579  [show with all ESTs]
    Unigene Representative Sequence: BX640643
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000478393 ENST00000252071(uc003wgu.2) ENST00000477871 ENST00000477367
    ENST00000539352(uc022aps.1)
    miRNA
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    hsa-miR-30c hsa-miR-642a hsa-miR-30a hsa-miR-30b hsa-miR-30d hsa-miR-30e
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
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    Additional mRNA sequence: 

    AB039791.1 AK127403.1 AK130039.1 BX640643.1 

    6 DOTS entries:

    DT.40192049  DT.40246551  DT.97768839  DT.100663830  DT.121069929  DT.121090397 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ACTR3C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCTTGGAGA
    ACTR3C Expression
    About this image


    See ACTR3C Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ACTR3C

    SOURCE GeneReport for Unigene cluster: Hs.664579

    UniProtKB/Swiss-Prot: ARP3C_HUMAN, Q9C0K3
    Tissue specificity: Expressed in kidney, stomach, spleen, bone marrow, uterus, testis, placenta, skeletal muscle,
    mammary gland, lung, fetal liver, and fetal kidney, but not detected in small intestine, brain, and thymus.
    Expressed in low-metastatic lung adenocarcinoma cells but not in high-metastatic ones

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACTR3C

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ACTR3C gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves ACTR3B6
    Uncharacterized protein
    44(a)
    possible ortholog
    2(6790127-6814661)
    lizard
    (Anolis carolinensis)
    Reptilia ACTR3B6
    Uncharacterized protein
    39(a)
    possible ortholog
    6(4522009-4550009)
    zebrafish
    (Danio rerio)
    Actinopterygii actr3b6
    ARP3 actin-related protein 3 homolog B (yeast)
    41(a)
    1 → many
    24(7404891-7435323)
    fruit fly
    (Drosophila melanogaster)
    Insecta Arp66B6
    Actin-related protein 66B
    36(a)
    possible ortholog
    3L(8106507-8109002)
    worm
    (Caenorhabditis elegans)
    Secernentea arx-16
    Actin-related protein 3
    33(a)
    possible ortholog
    I(2883496-2893718)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ARP36
    Essential component of the Arp2/3 complex, which i...
    27(a)
    1 → many
    X(557809-559158)
            Species with no ortholog for ACTR3C

    ENSEMBL Gene Tree for ACTR3C (if available)
    TreeFam Gene Tree for ACTR3C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ACTR3C gene
    ACTR32  ACTR3B2  
    18/20 SIMAP similar genes for ACTR3C using alignment to 4 protein entries:     ARP3C_HUMAN (see all proteins) (see all similar genes):
    ACTR3B    ACTR3    FKSG72    FKSG73    FKSG74    ACTB
    ACT    ACTG1    POTEM    ACTR1A    ACTA1    ACTC1
    ACTR2    ACTA2    ACTBL2    POTEF    POTEI    POTEJ

    ACTR3C for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1547 SNPs in ACTR3C are shown (see all 1547)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs38324911,2
    C--143801531(-) TTGAGG/-CCAGG 2 -- int11Minor allele frequency- -:0.00NA 2
    rs1851400931,2
    --149339921(+) CTGCCC/TGGGCT 1 -- us2k10--------
    rs625026411,2
    --149943841(+) AAATAC/TCACAA 2 -- int10--------
    rs1125610191,2
    C--149943870(+) TGGCTTTTTG/
            
    TTTTG
    2 -- int11Minor allele frequency- -:0.50CSA 2
    rs1411555641,2
    --149943943(+) ATGGCA/GTGATC 2 -- int10--------
    rs1850856911,2
    --149944043(+) CACCCA/GGTTAA 2 -- int10--------
    rs104292401,2
    C--149944073(+) aaagaC/Tggggt 2 -- int10--------
    rs1884042401,2
    --149944131(+) CTGCCC/TGCCTC 2 -- int10--------
    rs776996031,2
    C--149944152(+) AGTGCC/TGGGAT 2 -- int10--------
    rs1437736611,2
    C--149944478(+) CCCCAC/TGTAGT 2 -- ut310--------

    HapMap Linkage Disequilibrium report for ACTR3C (149941005 - 150020814 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for ACTR3C:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv435n21CNV Loss19592680
    nsv508490CNV Loss20534489
    nsv521407CNV Loss19592680
    dgv7541n71CNV Loss21882294
    nsv889452CNV Gain21882294
    nsv889435CNV Gain21882294
    dgv2151e1CNV Complex17122850


    Human Gene Mutation Database (HGMD): ACTR3C
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    4 diseases for ACTR3C:    About MalaCards
    lung adenoma    lung adenocarcinoma    adenoma    adenocarcinoma


    ACTR3C for disorders           About GeneDecksing


    Export disorders for ACTR3C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ACTR3C gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ACTR3C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of a novel actin-related gene expressed in low-metastatic PC-14 human lung adenocarcinoma. (PubMed id 11162478)1, 2, 3 Shindo-Okada N. and Shimizu K. (2001)
    2. Expression of the Arp11 gene suppresses the tumorigenicity of PC-14 human lung adenocarcinoma cells. (PubMed id 14651955)1, 3 Shindo-Okada N. and Iigo M. (2003)
    3. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    5. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 653857 HGNC: 37282 Ensembl:ENSG00000106526 euGenes: HUgn653857 ECgene: ACTR3C
    H-InvDB: ACTR3C

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ACTR3C Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ACTR3C gene:
    Search GeneIP for patents involving ACTR3C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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