Aliases for ACTR3B Gene
Aliases for ACTR3B Gene
External Ids for ACTR3B Gene
- HGNC: 17256
- Entrez Gene: 57180
- Ensembl: ENSG00000133627
- UniProtKB: Q9P1U1
Previous GeneCards Identifiers for ACTR3B Gene
- GC07P151895
- GC07P152087
- GC07P152456
- GC07P146267
Summaries for ACTR3B Gene
-
This gene encodes a member of the actin-related proteins (ARP), which form multiprotein complexes and share 35-55% amino acid identity with conventional actin. The protein encoded by this gene may have a regulatory role in the actin cytoskeleton and induce cell-shape change and motility. Pseudogenes of this gene are located on chromosomes 2, 4, 10, 16, 22 and Y. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jul 2012]
GeneCards Summary for ACTR3B Gene
ACTR3B (ARP3 Actin Related Protein 3 Homolog B) is a Protein Coding gene. Diseases associated with ACTR3B include Lung Cancer Susceptibility 3. Among its related pathways are Immune response CCR3 signaling in eosinophils and Development Slit-Robo signaling. GO annotations related to this gene include actin binding. An important paralog of this gene is ACTR3.
UniProtKB/Swiss-Prot for ACTR3B Gene
-
Plays a role in the organization of the actin cytoskeleton. May function as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. May decrease the metastatic potential of tumors.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACTR3B Gene
Genomics for ACTR3B Gene
Regulatory Elements for ACTR3B Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH07G152462 | 1.4 | FANTOM5 ENCODE | 4.7 | -295.8 | -295756 | 3.5 | CREB3L1 AGO1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC ZNF610 GLIS1 | LINC01003 ACTR3B GC07P152484 |
| GH07G152812 | 0.5 | dbSUPER | 9.2 | +53.8 | 53832 | 2.9 | BCOR NR2F1 BHLHE40 IKZF1 ZSCAN5C | ACTR3B GC07P152831 |
| GH07G152759 | 1.1 | ENCODE | 0.7 | +1.0 | 983 | 3.1 | HDGF PKNOX1 CREB3L1 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 YY1 | ACTR3B GC07P152831 |
| GH07G152973 | 0.3 | FANTOM5 | 1.7 | +213.4 | 213387 | 0.1 | ACTR3B GC07P152927 LOC101929087 | |
| GH07G152806 | 0.9 | Ensembl dbSUPER | 0.2 | +47.2 | 47152 | 0.2 | HDGF PKNOX1 MAFG ZNF175 NFIC FOXK2 IKZF1 PBX2 NFE2 | GC07P152831 ACTR3B |
- Transcription factor binding sites by QIAGEN in the ACTR3B gene promoter:
Regulatory Element Products
Genomic Location for ACTR3B Gene
- Chromosome:
- 7
- Start:
- 152,759,749 bp from pter
- End:
- 152,887,759 bp from pter
- Size:
- 128,011 bases
- Orientation:
- Plus strand
Genomic View for ACTR3B Gene
- Cytogenetic band:
-
- 7q36.1 by Ensembl
- 7q36.1-q36.2 by Entrez Gene
- 7q36.1-q36.2 by HGNC
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ACTR3B Gene
Proteins for ACTR3B Gene
-
Protein details for ACTR3B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9P1U1-ARP3B_HUMAN
- Recommended name:
- Actin-related protein 3B
- Protein Accession:
- Q9P1U1
- A8MTG1
- B4DFW4
- Q7Z526
- Q96BT2
Protein attributes for ACTR3B Gene
- Size:
- 418 amino acids
- Molecular mass:
- 47608 Da
- Quaternary structure:
-
- Interacts with the Arp2/3 complex composed of ARP2, ARP3, ARPC1B, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.
- SequenceCaution:
-
- Sequence=AAP97150.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};
Protein Expression for ACTR3B Gene
Post-translational modifications for ACTR3B Gene
Other Protein References for ACTR3B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
-
- NP_001035225.1
- NP_001337869.1
- NP_001337870.1
- NP_001337871.1
- NP_001337872.1
- NP_001337873.1
- NP_001337874.1
- NP_001337875.1
- NP_065178.1
- XP_006716128.1
- XP_006716129.1
- XP_006716130.1
- XP_011514727.1
- XP_011514728.1
- XP_011514729.1
- XP_016867949.1
- XP_016867950.1
- XP_016867951.1
- XP_016867952.1
- XP_016867953.1
- XP_016867954.1
Antibody Products
- Novus Biologicals Antibodies for ACTR3B
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- antibodies-online Antibodies for ACTR3B: See all 39
- GeneTex ACTR3B antibody for ACTR3B
Protein Products
-
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- antibodies-online Proteins for ACTR3B: See all 3
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- Search GeneTex for Proteins for ACTR3B
Assay Products
No data available for DME Specific Peptides for ACTR3B Gene
Domains & Families for ACTR3B Gene
Gene Families for ACTR3B Gene
Protein Domains for ACTR3B Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for ACTR3B Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9P1U1- Family:
-
- Belongs to the actin family. ARP3 subfamily.
Function for ACTR3B Gene
Molecular function for ACTR3B Gene
- UniProtKB/Swiss-Prot Function:
- Plays a role in the organization of the actin cytoskeleton. May function as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. May decrease the metastatic potential of tumors.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003674 | molecular_function | ND | -- |
| GO:0003779 | actin binding | IEA | -- |
| GO:0005524 | ATP binding | IEA | -- |
Phenotypes for ACTR3B Gene
Animal Model Products
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-
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-
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CRISPR Products
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OriGene CRISPR knockouts for ACTR3B
-
Santa Cruz Biotechnology (SCBT) CRISPR for ACTR3B
- GenScript: Design CRISPR guide RNA sequences for ACTR3B
miRNA for ACTR3B Gene
- miRTarBase miRNAs that target ACTR3B
-
- hsa-mir-379-3p (MIRT441273)
- hsa-mir-487a-3p (MIRT441274)
- hsa-mir-539-3p (MIRT441275)
- hsa-mir-127-3p (MIRT441276)
- hsa-mir-4524b-5p (MIRT461536)
- hsa-mir-4524a-5p (MIRT461537)
- hsa-mir-4710 (MIRT461538)
- hsa-mir-8085 (MIRT461539)
- hsa-mir-6731-5p (MIRT461540)
- hsa-mir-6797-5p (MIRT461541)
- hsa-mir-1249-5p (MIRT461542)
- hsa-mir-765 (MIRT461543)
- hsa-mir-621 (MIRT461544)
- hsa-mir-4660 (MIRT461545)
- hsa-mir-6804-5p (MIRT461546)
- hsa-mir-6133 (MIRT461547)
- hsa-mir-6130 (MIRT461548)
- hsa-mir-6129 (MIRT461549)
- hsa-mir-6127 (MIRT461550)
- hsa-mir-4510 (MIRT461551)
- hsa-mir-4419a (MIRT461552)
- hsa-mir-5690 (MIRT461553)
- hsa-mir-6760-5p (MIRT461554)
- hsa-mir-4779 (MIRT461555)
- hsa-mir-646 (MIRT461556)
- hsa-mir-503-5p (MIRT461557)
- hsa-mir-6838-5p (MIRT461558)
- hsa-mir-497-5p (MIRT461559)
- hsa-mir-424-5p (MIRT461560)
- hsa-mir-195-5p (MIRT461561)
- hsa-mir-16-5p (MIRT461562)
- hsa-mir-15b-5p (MIRT461563)
- hsa-mir-15a-5p (MIRT461564)
miRNA Products
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
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Horizon Cell Lines for ACTR3B
-
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-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ACTR3B Gene
Localization for ACTR3B Gene
Subcellular locations from UniProtKB/Swiss-Prot for ACTR3B Gene
- Cytoplasm, cytoskeleton. Cell projection.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005856 | cytoskeleton | IEA | -- |
| GO:0005885 | Arp2/3 protein complex | IEA | -- |
| GO:0042995 | cell projection | IEA | -- |
| GO:0070062 | extracellular exosome | IDA | 23533145 |
Pathways & Interactions for ACTR3B Gene
Pathways by source for ACTR3B Gene
1 KEGG pathway for ACTR3B Gene
14 GeneGo (Thomson Reuters) pathways for ACTR3B Gene
Interacting Proteins for ACTR3B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007015 | actin filament organization | IEA | -- |
| GO:0008150 | biological_process | ND | -- |
| GO:0034314 | Arp2/3 complex-mediated actin nucleation | IEA | -- |
No data available for SIGNOR curated interactions for ACTR3B Gene
Transcripts for ACTR3B Gene
mRNA/cDNA for ACTR3B Gene
- (21) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (21) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ACTR3B Gene
CRISPR Products
-
OriGene CRISPR knockouts for ACTR3B
-
Santa Cruz Biotechnology (SCBT) CRISPR for ACTR3B
- GenScript: Design CRISPR guide RNA sequences for ACTR3B
miRNA Products
- Search ViGene Biosciences for ACTR3B
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for ACTR3B
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-
ViGene Biosciences ready-to-package AAV shRNAs for ACTR3B gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ACTR3B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ACTR3B
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||||||
| SP5: | - | ||||||||||||||||||||||||||||||||
| SP6: | - |
Expression for ACTR3B Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Epiblast (Early Embryonic Tissues)
- Intraembryonic Epiblast Cells Epiblast
-
Heart (Cardiovascular System)
mRNA differential expression in normal tissues according to GTEx for ACTR3B Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ACTR3B Gene
NURSA nuclear receptor signaling pathways regulating expression of ACTR3B Gene:
ACTR3BSOURCE GeneReport for Unigene cluster for ACTR3B Gene:
Hs.647117mRNA Expression by UniProt/SwissProt for ACTR3B Gene:
Q9P1U1-ARP3B_HUMANEvidence on tissue expression from TISSUES for ACTR3B Gene
- Nervous system(4.7)
- Blood(4.2)
- Intestine(4.2)
- Skin(4.1)
Primer Products
-
OriGene qPCR primer pairs for ACTR3B
-
OriGene qPCR primer pairs and template standards for ACTR3B
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ACTR3B Gene
Orthologs for ACTR3B Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ACTR3B 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | ACTR3B 35 |
|
OneToOne | |
| ACTR3 34 |
|
||||
| oppossum (Monodelphis domestica) |
Mammalia | -- 35 |
|
OneToMany | |
| cow (Bos Taurus) |
Mammalia | -- 35 |
|
OneToMany | |
| ACTR3B 34 |
|
||||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
OneToMany | |
| rat (Rattus norvegicus) |
Mammalia | Actr3b 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Actr3b 34 16 35 |
|
||
| chicken (Gallus gallus) |
Aves | -- 35 |
|
OneToMany | |
| ACTR3B 34 |
|
||||
| lizard (Anolis carolinensis) |
Reptilia | -- 35 |
|
OneToMany | |
| zebrafish (Danio rerio) |
Actinopterygii | actr3b 35 |
|
OneToMany | |
| fruit fly (Drosophila melanogaster) |
Insecta | Arp66B 35 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | arx-1 35 |
|
OneToMany | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | ARP3 35 37 |
|
OneToMany | |
| thale cress (Arabidopsis thaliana) |
eudicotyledons | DIS1 34 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os02g0596900 34 |
|
||
| wheat (Triticum aestivum) |
Liliopsida | Ta.22891 34 |
|
||
| corn (Zea mays) |
Liliopsida | Zm.1412 34 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany |
- Species where no ortholog for ACTR3B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
Paralogs for ACTR3B Gene
(25) SIMAP similar genes for ACTR3B Gene using alignment to 1 proteins:
Pseudogenes.org Pseudogenes for ACTR3B Gene
Variants for ACTR3B Gene
| SNP ID | Clin | Chr 07 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000004919 | -- | 153,017,382(+) | TCGCC(C/G)TGTGT | intron-variant | |
| rs1000037471 | -- | 152,898,458(+) | GGGGC(A/T)TCCAT | intron-variant | |
| rs1000043079 | -- | 153,053,340(+) | TTCCA(A/G)AACAT | intron-variant | |
| rs1000043332 | -- | 153,004,680(+) | CCATG(A/C)TTTAC | intron-variant | |
| rs1000057181 | -- | 152,914,143(+) | CCATC(A/G)TCATC | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1340e214 | CNV | gain | 21293372 |
| dgv3695n106 | OTHER | inversion | 24896259 |
| esv2735460 | CNV | deletion | 23290073 |
| esv3615526 | CNV | gain | 21293372 |
| esv3615528 | CNV | gain | 21293372 |
| esv3615531 | CNV | gain | 21293372 |
| esv3615532 | CNV | gain | 21293372 |
| nsv1067934 | OTHER | inversion | 25765185 |
| nsv1076019 | CNV | deletion | 25765185 |
| nsv1133676 | CNV | deletion | 24896259 |
| nsv1151906 | OTHER | inversion | 26484159 |
| nsv475132 | CNV | novel sequence insertion | 20440878 |
| nsv831193 | CNV | loss | 17160897 |
| nsv966912 | CNV | duplication | 23825009 |
| nsv966913 | CNV | duplication | 23825009 |
| nsv970617 | CNV | duplication | 23825009 |
| nsv970977 | CNV | duplication | 23825009 |
| nsv970978 | CNV | duplication | 23825009 |
| nsv981617 | CNV | duplication | 23825009 |
Relevant External Links for ACTR3B Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ACTR3B
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACTR3B Gene
Disorders for ACTR3B Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| lung cancer susceptibility 3 |
|
Relevant External Links for ACTR3B
No data available for UniProtKB/Swiss-Prot and Genatlas for ACTR3B Gene
Publications for ACTR3B Gene
- ARP3beta, the gene encoding a new human actin-related protein, is alternatively spliced and predominantly expressed in brain neuronal cells. (PMID: 10806390) Jay P. … Berta P. (Eur. J. Biochem. 2000) 2 3 4 22 64
- Expression of the Arp11 gene suppresses the tumorigenicity of PC-14 human lung adenocarcinoma cells. (PMID: 14651955) Shindo-Okada N. … Iigo M. (Biochem. Biophys. Res. Commun. 2003) 3 4 22 64
- Isolation of a novel actin-related gene expressed in low-metastatic PC-14 human lung adenocarcinoma. (PMID: 11162478) Shindo-Okada N. … Shimizu K. (Biochem. Biophys. Res. Commun. 2001) 3 4 22 64
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
Products for ACTR3B Gene
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- antibodies-online Antibodies for ACTR3B: See all 39
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- GeneTex ACTR3B antibody for ACTR3B
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- ViGene Biosciences adenoviral particle packaged cDNA for ACTR3B gene
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- Horizon Cell Lines for ACTR3B
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- VectorBuilder custom plasmid, inducible vectors for ACTR3B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ACTR3B
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for ACTR3B Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
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- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
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- (92) Vector BioLabs
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- (141) ENCODE
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- (150) St John's Lab
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- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer




