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Aliases for ACTR3B Gene

Aliases for ACTR3B Gene

  • ARP3 Actin Related Protein 3 Homolog B 2 3 5
  • Actin-Related Protein ARP4 3 4
  • Actin-Like Protein 3B 3 4
  • ARP3-Beta 3 4
  • Arp11 3 4
  • ARP3 Actin-Related Protein 3 Homolog B (Yeast) 2
  • Actin-Related Protein 3-Beta 3
  • Actin-Related Protein Arp11 3
  • Actin-Related Protein 3B 3
  • ARP3BETA 3
  • Arp4 4

External Ids for ACTR3B Gene

Previous GeneCards Identifiers for ACTR3B Gene

  • GC07P151895
  • GC07P152087
  • GC07P152456
  • GC07P146267

Summaries for ACTR3B Gene

Entrez Gene Summary for ACTR3B Gene

  • This gene encodes a member of the actin-related proteins (ARP), which form multiprotein complexes and share 35-55% amino acid identity with conventional actin. The protein encoded by this gene may have a regulatory role in the actin cytoskeleton and induce cell-shape change and motility. Pseudogenes of this gene are located on chromosomes 2, 4, 10, 16, 22 and Y. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jul 2012]

GeneCards Summary for ACTR3B Gene

ACTR3B (ARP3 Actin Related Protein 3 Homolog B) is a Protein Coding gene. Diseases associated with ACTR3B include Lung Cancer Susceptibility 3. Among its related pathways are Immune response Role of DAP12 receptors in NK cells and EphB-EphrinB Signaling. GO annotations related to this gene include actin binding. An important paralog of this gene is ACTR3.

UniProtKB/Swiss-Prot for ACTR3B Gene

  • Plays a role in the organization of the actin cytoskeleton. May function as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. May decrease the metastatic potential of tumors.

Gene Wiki entry for ACTR3B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACTR3B Gene

Genomics for ACTR3B Gene

Regulatory Elements for ACTR3B Gene

Enhancers for ACTR3B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F152462 1.4 FANTOM5 ENCODE 4.7 -295.8 -295756 3.5 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 LINC01003 ACTR3B GC07P152484
GH07F152759 1.1 ENCODE 0.8 +1.0 983 3.1 PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 YY1 NFYC ZHX2 ENSG00000229591 ACTR3B GC07P152831
GH07F152973 0.3 FANTOM5 1.7 +213.4 213387 0.1 ACTR3B GC07P152927 LOC101929087
GH07F152775 0.7 Ensembl 0.3 +15.6 15552 0.6 RNF2 NR2F1 MAFG CEBPB BACH1 DPF2 ARID1B ZNF316 ZNF766 NCOR1 ACTR3B GC07P152831
GH07F152770 0.4 Ensembl 0.4 +11.5 11452 0.8 BCOR ZBTB33 ACTR3B GC07P152831
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ACTR3B on UCSC Golden Path with GeneCards custom track

Promoters for ACTR3B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000070070 352 1800 PKNOX1 ATF1 CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF48 BRCA1 YY1

Genomic Location for ACTR3B Gene

Chromosome:
7
Start:
152,759,749 bp from pter
End:
152,887,759 bp from pter
Size:
128,011 bases
Orientation:
Plus strand

Genomic View for ACTR3B Gene

Genes around ACTR3B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACTR3B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACTR3B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACTR3B Gene

Proteins for ACTR3B Gene

  • Protein details for ACTR3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P1U1-ARP3B_HUMAN
    Recommended name:
    Actin-related protein 3B
    Protein Accession:
    Q9P1U1
    Secondary Accessions:
    • A8MTG1
    • B4DFW4
    • Q7Z526
    • Q96BT2

    Protein attributes for ACTR3B Gene

    Size:
    418 amino acids
    Molecular mass:
    47608 Da
    Quaternary structure:
    • Interacts with the Arp2/3 complex composed of ARP2, ARP3, ARPC1B, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.
    SequenceCaution:
    • Sequence=AAP97150.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

    Alternative splice isoforms for ACTR3B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ACTR3B Gene

Post-translational modifications for ACTR3B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ACTR3B Gene

Domains & Families for ACTR3B Gene

Protein Domains for ACTR3B Gene

Suggested Antigen Peptide Sequences for ACTR3B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9P1U1

UniProtKB/Swiss-Prot:

ARP3B_HUMAN :
  • Belongs to the actin family. ARP3 subfamily.
Family:
  • Belongs to the actin family. ARP3 subfamily.
genes like me logo Genes that share domains with ACTR3B: view

No data available for Gene Families for ACTR3B Gene

Function for ACTR3B Gene

Molecular function for ACTR3B Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the organization of the actin cytoskeleton. May function as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. May decrease the metastatic potential of tumors.

Gene Ontology (GO) - Molecular Function for ACTR3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003779 actin binding IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with ACTR3B: view
genes like me logo Genes that share phenotypes with ACTR3B: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ACTR3B Gene

Localization for ACTR3B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACTR3B Gene

Cytoplasm, cytoskeleton. Cell projection.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ACTR3B gene
Compartment Confidence
extracellular 5
cytoskeleton 3
cytosol 3
nucleus 2
plasma membrane 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ACTR3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005885 Arp2/3 protein complex IEA --
GO:0042995 cell projection IEA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with ACTR3B: view

Pathways & Interactions for ACTR3B Gene

genes like me logo Genes that share pathways with ACTR3B: view

Gene Ontology (GO) - Biological Process for ACTR3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007015 actin filament organization IEA --
GO:0008150 biological_process ND --
GO:0034314 Arp2/3 complex-mediated actin nucleation IEA --
genes like me logo Genes that share ontologies with ACTR3B: view

No data available for SIGNOR curated interactions for ACTR3B Gene

Transcripts for ACTR3B Gene

Unigene Clusters for ACTR3B Gene

ARP3 actin-related protein 3 homolog B (yeast):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ACTR3B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b
SP1:
SP2: - - -
SP3: - -
SP4: -
SP5: -
SP6: -

Relevant External Links for ACTR3B Gene

GeneLoc Exon Structure for
ACTR3B
ECgene alternative splicing isoforms for
ACTR3B

Expression for ACTR3B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ACTR3B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ACTR3B Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x4.9).

Protein differential expression in normal tissues from HIPED for ACTR3B Gene

This gene is overexpressed in Adipocyte (17.8), Tlymphocyte (11.0), Cervix (9.0), and Monocytes (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ACTR3B Gene



NURSA nuclear receptor signaling pathways regulating expression of ACTR3B Gene:

ACTR3B

SOURCE GeneReport for Unigene cluster for ACTR3B Gene:

Hs.647117

mRNA Expression by UniProt/SwissProt for ACTR3B Gene:

Q9P1U1-ARP3B_HUMAN
Tissue specificity: Detected in fetal brain. Detected throughout the adult brain, in neurons from gray matter, but not in white matter. Detected in liver, skeletal muscle and pancreas. Detected in lung adenocarcinoma cells with low metastatic potential, but not in lung adenocarcinoma cells with high metastatic potential.
genes like me logo Genes that share expression patterns with ACTR3B: view

No data available for Protein tissue co-expression partners for ACTR3B Gene

Orthologs for ACTR3B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ACTR3B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ACTR3B 34 35
  • 99.68 (n)
dog
(Canis familiaris)
Mammalia ACTR3B 35
  • 99 (a)
OneToOne
ACTR3 34
  • 91.07 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 98 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 35
  • 97 (a)
OneToMany
ACTR3B 34
  • 88.68 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 93 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Actr3b 34
  • 90.91 (n)
mouse
(Mus musculus)
Mammalia Actr3b 34 16 35
  • 89.87 (n)
chicken
(Gallus gallus)
Aves -- 35
  • 96 (a)
OneToMany
ACTR3B 34
  • 84.05 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 84 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii actr3b 35
  • 85 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Arp66B 35
  • 76 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea arx-1 35
  • 69 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARP3 35 37
  • 55 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons DIS1 34
  • 59.82 (n)
rice
(Oryza sativa)
Liliopsida Os02g0596900 34
  • 58.23 (n)
wheat
(Triticum aestivum)
Liliopsida Ta.22891 34
corn
(Zea mays)
Liliopsida Zm.1412 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 81 (a)
OneToMany
Species where no ortholog for ACTR3B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)

Evolution for ACTR3B Gene

ENSEMBL:
Gene Tree for ACTR3B (if available)
TreeFam:
Gene Tree for ACTR3B (if available)

Paralogs for ACTR3B Gene

Paralogs for ACTR3B Gene

genes like me logo Genes that share paralogs with ACTR3B: view

Variants for ACTR3B Gene

Sequence variations from dbSNP and Humsavar for ACTR3B Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs10085365 -- 152,821,906(+) TGAGC(A/G)CACCA intron-variant
rs1012472 -- 153,061,386(+) tctct(C/G)cagga intron-variant
rs1015997 -- 153,061,566(+) tggaa(A/G)cctta intron-variant
rs10225261 -- 152,966,569(+) cagct(C/T)tacat intron-variant
rs10225366 -- 152,966,620(+) tctgt(C/T)gccca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ACTR3B Gene

Variant ID Type Subtype PubMed ID
nsv981617 CNV duplication 23825009
nsv970978 CNV duplication 23825009
nsv970977 CNV duplication 23825009
nsv970617 CNV duplication 23825009
nsv966913 CNV duplication 23825009
nsv966912 CNV duplication 23825009
nsv831193 CNV loss 17160897
nsv475132 CNV novel sequence insertion 20440878
nsv1151906 OTHER inversion 26484159
nsv1133676 CNV deletion 24896259
nsv1076019 CNV deletion 25765185
nsv1067934 OTHER inversion 25765185
esv3615532 CNV gain 21293372
esv3615531 CNV gain 21293372
esv3615528 CNV gain 21293372
esv3615526 CNV gain 21293372
esv2735460 CNV deletion 23290073
dgv3695n106 OTHER inversion 24896259
dgv1340e214 CNV gain 21293372

Variation tolerance for ACTR3B Gene

Residual Variation Intolerance Score: 41.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.33; 7.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ACTR3B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ACTR3B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACTR3B Gene

Disorders for ACTR3B Gene

MalaCards: The human disease database

(1) MalaCards diseases for ACTR3B Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
lung cancer susceptibility 3
  • lung adenocarcinoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ACTR3B

Genetic Association Database (GAD)
ACTR3B
Human Genome Epidemiology (HuGE) Navigator
ACTR3B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ACTR3B
genes like me logo Genes that share disorders with ACTR3B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ACTR3B Gene

Publications for ACTR3B Gene

  1. ARP3beta, the gene encoding a new human actin-related protein, is alternatively spliced and predominantly expressed in brain neuronal cells. (PMID: 10806390) Jay P. … Berta P. (Eur. J. Biochem. 2000) 2 3 4 22 64
  2. Expression of the Arp11 gene suppresses the tumorigenicity of PC-14 human lung adenocarcinoma cells. (PMID: 14651955) Shindo-Okada N. … Iigo M. (Biochem. Biophys. Res. Commun. 2003) 3 4 22 64
  3. Isolation of a novel actin-related gene expressed in low-metastatic PC-14 human lung adenocarcinoma. (PMID: 11162478) Shindo-Okada N. … Shimizu K. (Biochem. Biophys. Res. Commun. 2001) 3 4 22 64
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for ACTR3B Gene

Sources for ACTR3B Gene

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