Aliases for ACTR3B Gene
External Ids for ACTR3B Gene
Previous GeneCards Identifiers for ACTR3B Gene
This gene encodes a member of the actin-related proteins (ARP), which form multiprotein complexes and share 35-55% amino acid identity with conventional actin. The protein encoded by this gene may have a regulatory role in the actin cytoskeleton and induce cell-shape change and motility. Pseudogenes of this gene are located on chromosomes 2, 4, 10, 16, 22 and Y. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jul 2012]
GeneCards Summary for ACTR3B Gene
ACTR3B (ARP3 Actin Related Protein 3 Homolog B) is a Protein Coding gene. Diseases associated with ACTR3B include Lung Cancer Susceptibility 3. Among its related pathways are Immune response CCR3 signaling in eosinophils and Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases. GO annotations related to this gene include actin binding. An important paralog of this gene is ACTR3.
UniProtKB/Swiss-Prot for ACTR3B Gene
Plays a role in the organization of the actin cytoskeleton. May function as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. May decrease the metastatic potential of tumors.