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Aliases for ACTR3B Gene

Aliases for ACTR3B Gene

  • ARP3 Actin-Related Protein 3 Homolog B (Yeast) 2 3 5
  • Actin-Related Protein ARP4 3 4
  • Actin-Like Protein 3B 3 4
  • ARP3-Beta 3 4
  • Arp11 3 4
  • Actin-Related Protein 3-Beta 3
  • Actin-Related Protein Arp11 3
  • ARP3BETA 3
  • Arp4 4

External Ids for ACTR3B Gene

Previous GeneCards Identifiers for ACTR3B Gene

  • GC07P151895
  • GC07P152087
  • GC07P152456
  • GC07P146267

Summaries for ACTR3B Gene

Entrez Gene Summary for ACTR3B Gene

  • This gene encodes a member of the actin-related proteins (ARP), which form multiprotein complexes and share 35-55% amino acid identity with conventional actin. The protein encoded by this gene may have a regulatory role in the actin cytoskeleton and induce cell-shape change and motility. Pseudogenes of this gene are located on chromosomes 2, 4, 10, 16, 22 and Y. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jul 2012]

GeneCards Summary for ACTR3B Gene

ACTR3B (ARP3 Actin-Related Protein 3 Homolog B (Yeast)) is a Protein Coding gene. Diseases associated with ACTR3B include lung cancer susceptibility 3. Among its related pathways are Development Slit-Robo signaling and Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases. GO annotations related to this gene include actin binding. An important paralog of this gene is ACTR3C.

UniProtKB/Swiss-Prot for ACTR3B Gene

  • Plays a role in the organization of the actin cytoskeleton. May function as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. May decrease the metastatic potential of tumors.

Gene Wiki entry for ACTR3B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACTR3B Gene

Genomics for ACTR3B Gene

Regulatory Elements for ACTR3B Gene

Promoters for ACTR3B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ACTR3B on UCSC Golden Path with GeneCards custom track

Genomic Location for ACTR3B Gene

Chromosome:
7
Start:
152,759,749 bp from pter
End:
152,887,759 bp from pter
Size:
128,011 bases
Orientation:
Plus strand

Genomic View for ACTR3B Gene

Genes around ACTR3B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACTR3B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACTR3B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACTR3B Gene

Proteins for ACTR3B Gene

  • Protein details for ACTR3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P1U1-ARP3B_HUMAN
    Recommended name:
    Actin-related protein 3B
    Protein Accession:
    Q9P1U1
    Secondary Accessions:
    • A8MTG1
    • B4DFW4
    • Q7Z526
    • Q96BT2

    Protein attributes for ACTR3B Gene

    Size:
    418 amino acids
    Molecular mass:
    47608 Da
    Quaternary structure:
    • Interacts with the Arp2/3 complex composed of ARP2, ARP3, ARPC1B, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.
    SequenceCaution:
    • Sequence=AAP97150.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

    Alternative splice isoforms for ACTR3B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ACTR3B Gene

Proteomics data for ACTR3B Gene at MOPED

Post-translational modifications for ACTR3B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ACTR3B Gene

No data available for DME Specific Peptides for ACTR3B Gene

Domains & Families for ACTR3B Gene

Protein Domains for ACTR3B Gene

Suggested Antigen Peptide Sequences for ACTR3B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9P1U1

UniProtKB/Swiss-Prot:

ARP3B_HUMAN :
  • Belongs to the actin family. ARP3 subfamily.
Family:
  • Belongs to the actin family. ARP3 subfamily.
genes like me logo Genes that share domains with ACTR3B: view

No data available for Gene Families for ACTR3B Gene

Function for ACTR3B Gene

Molecular function for ACTR3B Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the organization of the actin cytoskeleton. May function as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. May decrease the metastatic potential of tumors.

Gene Ontology (GO) - Molecular Function for ACTR3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with ACTR3B: view
genes like me logo Genes that share phenotypes with ACTR3B: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ACTR3B Gene

Localization for ACTR3B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACTR3B Gene

Cytoplasm, cytoskeleton. Cell projection.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ACTR3B Gene COMPARTMENTS Subcellular localization image for ACTR3B gene
Compartment Confidence
extracellular 5
cytoskeleton 3
cytosol 3
nucleus 2
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ACTR3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with ACTR3B: view

Pathways & Interactions for ACTR3B Gene

genes like me logo Genes that share pathways with ACTR3B: view

Gene Ontology (GO) - Biological Process for ACTR3B Gene

None

No data available for SIGNOR curated interactions for ACTR3B Gene

Drugs & Compounds for ACTR3B Gene

No Compound Related Data Available

Transcripts for ACTR3B Gene

Unigene Clusters for ACTR3B Gene

ARP3 actin-related protein 3 homolog B (yeast):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ACTR3B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b
SP1:
SP2: - - -
SP3: - -
SP4: -
SP5: -
SP6: -

Relevant External Links for ACTR3B Gene

GeneLoc Exon Structure for
ACTR3B
ECgene alternative splicing isoforms for
ACTR3B

Expression for ACTR3B Gene

mRNA expression in normal human tissues for ACTR3B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ACTR3B Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x4.9).

Protein differential expression in normal tissues from HIPED for ACTR3B Gene

This gene is overexpressed in Adipocyte (17.8), Tlymphocyte (11.0), Cervix (9.0), and Monocytes (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ACTR3B Gene



SOURCE GeneReport for Unigene cluster for ACTR3B Gene Hs.647117

mRNA Expression by UniProt/SwissProt for ACTR3B Gene

Q9P1U1-ARP3B_HUMAN
Tissue specificity: Detected in fetal brain. Detected throughout the adult brain, in neurons from gray matter, but not in white matter. Detected in liver, skeletal muscle and pancreas. Detected in lung adenocarcinoma cells with low metastatic potential, but not in lung adenocarcinoma cells with high metastatic potential.
genes like me logo Genes that share expression patterns with ACTR3B: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for ACTR3B Gene

Orthologs for ACTR3B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ACTR3B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ACTR3B 36
  • 100 (a)
OneToOne
ACTR3B 35
  • 99.68 (n)
  • 100 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 93 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Actr3b 36
  • 99 (a)
OneToOne
Actr3b 16
Actr3b 35
  • 89.87 (n)
  • 98.56 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 98 (a)
OneToMany
dog
(Canis familiaris)
Mammalia ACTR3B 36
  • 99 (a)
OneToOne
ACTR3 35
  • 91.07 (n)
  • 99.04 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 97 (a)
OneToMany
ACTR3B 35
  • 88.68 (n)
  • 97.85 (a)
rat
(Rattus norvegicus)
Mammalia Actr3b 35
  • 90.91 (n)
  • 98.33 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 96 (a)
OneToMany
ACTR3B 35
  • 84.05 (n)
  • 96.65 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 84 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii actr3b 36
  • 85 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Arp66B 36
  • 76 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea arx-1 36
  • 69 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARP3 38
ARP3 36
  • 55 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons DIS1 35
  • 59.82 (n)
  • 61.61 (a)
corn
(Zea mays)
Liliopsida Zm.1412 35
wheat
(Triticum aestivum)
Liliopsida Ta.22891 35
rice
(Oryza sativa)
Liliopsida Os02g0596900 35
  • 58.23 (n)
  • 59.61 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 81 (a)
OneToMany
Species with no ortholog for ACTR3B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)

Evolution for ACTR3B Gene

ENSEMBL:
Gene Tree for ACTR3B (if available)
TreeFam:
Gene Tree for ACTR3B (if available)

Paralogs for ACTR3B Gene

Paralogs for ACTR3B Gene

genes like me logo Genes that share paralogs with ACTR3B: view

Variants for ACTR3B Gene

Sequence variations from dbSNP and Humsavar for ACTR3B Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs2260545 - 152,823,406(+) TCCCC(A/G)GAAGT nc-transcript-variant, reference, missense
rs11103 -- 152,854,703(-) GAAGG(A/C/G)CCCGC intron-variant, nc-transcript-variant, utr-variant-3-prime
rs940261 -- 152,848,266(-) CACCG(C/T)AGTGT intron-variant
rs940262 -- 152,847,552(-) CACTA(A/G)AAGGC intron-variant
rs940267 -- 152,882,272(+) TGGGC(C/T)CAGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ACTR3B Gene

Variant ID Type Subtype PubMed ID
nsv831193 CNV Loss 17160897
nsv889506 CNV Loss 21882294
esv2735460 CNV Deletion 23290073

Variation tolerance for ACTR3B Gene

Residual Variation Intolerance Score: 41.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.33; 7.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ACTR3B Gene

HapMap Linkage Disequilibrium report
ACTR3B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACTR3B Gene

Disorders for ACTR3B Gene

MalaCards: The human disease database

(1) MalaCards diseases for ACTR3B Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
lung cancer susceptibility 3
  • lung adenocarcinoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ACTR3B

Genetic Association Database (GAD)
ACTR3B
Human Genome Epidemiology (HuGE) Navigator
ACTR3B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ACTR3B
genes like me logo Genes that share disorders with ACTR3B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ACTR3B Gene

Publications for ACTR3B Gene

  1. ARP3beta, the gene encoding a new human actin-related protein, is alternatively spliced and predominantly expressed in brain neuronal cells. (PMID: 10806390) Jay P. … Berta P. (Eur. J. Biochem. 2000) 2 3 4 23 67
  2. Derangement of hypothetical proteins in fetal Down's syndrome brain. (PMID: 15176487) Shin J.H. … Lubec G. (Neurochem. Res. 2004) 3 23
  3. Expression of the Arp11 gene suppresses the tumorigenicity of PC-14 human lung adenocarcinoma cells. (PMID: 14651955) Shindo-Okada N. … Iigo M. (Biochem. Biophys. Res. Commun. 2003) 3 23
  4. Isolation of a novel actin-related gene expressed in low-metastatic PC-14 human lung adenocarcinoma. (PMID: 11162478) Shindo-Okada N. … Shimizu K. (Biochem. Biophys. Res. Commun. 2001) 3 23
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for ACTR3B Gene

Sources for ACTR3B Gene

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