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Aliases for ACTR3 Gene

Aliases for ACTR3 Gene

  • ARP3 Actin-Related Protein 3 Homolog (Yeast) 2 3
  • ARP3 3 4 6
  • Actin-Like Protein 3 3 4
  • ARP3 (Actin-Related Protein 3, Yeast) Homolog 2
  • Actin-Related Protein 3 3

External Ids for ACTR3 Gene

Previous GeneCards Identifiers for ACTR3 Gene

  • GC02P111853
  • GC02P112568
  • GC02P114554
  • GC02P114742
  • GC02P114363
  • GC02P114647
  • GC02P106964

Summaries for ACTR3 Gene

Entrez Gene Summary for ACTR3 Gene

  • The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and motility through lamellipodial actin assembly and protrusion. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Mar 2013]

GeneCards Summary for ACTR3 Gene

ACTR3 (ARP3 Actin-Related Protein 3 Homolog (Yeast)) is a Protein Coding gene. Among its related pathways are RhoGDI Pathway and ERK Signaling. GO annotations related to this gene include actin binding. An important paralog of this gene is ACTR3B.

UniProtKB/Swiss-Prot for ACTR3 Gene

  • Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament. Plays a role in ciliogenesis.

Gene Wiki entry for ACTR3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACTR3 Gene

Genomics for ACTR3 Gene

Regulatory Elements for ACTR3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ACTR3 Gene

Start:
113,889,934 bp from pter
End:
113,962,596 bp from pter
Size:
72,663 bases
Orientation:
Plus strand

Genomic View for ACTR3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ACTR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACTR3 Gene

Proteins for ACTR3 Gene

  • Protein details for ACTR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61158-ARP3_HUMAN
    Recommended name:
    Actin-related protein 3
    Protein Accession:
    P61158
    Secondary Accessions:
    • P32391
    • Q53QM2

    Protein attributes for ACTR3 Gene

    Size:
    418 amino acids
    Molecular mass:
    47371 Da
    Quaternary structure:
    • Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC. Interacts with WHDC1. Interacts weakly with MEFV.

neXtProt entry for ACTR3 Gene

Proteomics data for ACTR3 Gene at MOPED

Post-translational modifications for ACTR3 Gene

  • Ubiquitination at Lys38, Lys53, Lys69, Lys75, Lys99, Lys191, Lys240, Lys251, Lys254, Lys265, Lys317, Lys348, Lys359, and Lys361
  • Modification sites at PhosphoSitePlus

Other Protein References for ACTR3 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ACTR3 (Arp3)

No data available for DME Specific Peptides for ACTR3 Gene

Domains for ACTR3 Gene

Protein Domains for ACTR3 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

P61158

UniProtKB/Swiss-Prot:

ARP3_HUMAN :
  • P61158
Family:
  • Belongs to the actin family. ARP3 subfamily.
genes like me logo Genes that share domains with ACTR3: view

No data available for Gene Families for ACTR3 Gene

Function for ACTR3 Gene

Molecular function for ACTR3 Gene

UniProtKB/Swiss-Prot Function: Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament. Plays a role in ciliogenesis.

Gene Ontology (GO) - Molecular Function for ACTR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005200 structural constituent of cytoskeleton IDA 11741539
GO:0005515 protein binding IPI 20195357
GO:0005524 ATP binding IEA --
GO:0051015 contributes_to actin filament binding IDA 11741539
genes like me logo Genes that share ontologies with ACTR3: view
genes like me logo Genes that share phenotypes with ACTR3: view

Animal Model Products

CRISPR Products

miRNA for ACTR3 Gene

miRTarBase miRNAs that target ACTR3

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ACTR3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ACTR3 Gene

Localization for ACTR3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACTR3 Gene

Cytoplasm, cytoskeleton. Cell projection. Note=In pre-apoptotic cells, colocalizes with MEFV in large specks (pyroptosomes).

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ACTR3 Gene COMPARTMENTS Subcellular localization image for ACTR3 gene
Compartment Confidence
cytoskeleton 5
cytosol 4
golgi apparatus 2
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ACTR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0002102 podosome IEA --
GO:0005737 cytoplasm --
GO:0005829 cytosol TAS --
GO:0005884 actin filament IEA --
genes like me logo Genes that share ontologies with ACTR3: view

Pathways for ACTR3 Gene

genes like me logo Genes that share pathways with ACTR3: view

PCR Array Products

Gene Ontology (GO) - Biological Process for ACTR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006928 movement of cell or subcellular component TAS 9230079
GO:0007163 establishment or maintenance of cell polarity IEA --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0007411 axon guidance TAS --
GO:0008356 asymmetric cell division IEA --
genes like me logo Genes that share ontologies with ACTR3: view

Compounds for ACTR3 Gene

(2) Drugbank Compounds for ACTR3 Gene

(2) Novoseek inferred chemical compound relationships for ACTR3 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 24 1
phosphatidylinositol 10.7 1
genes like me logo Genes that share compounds with ACTR3: view

Transcripts for ACTR3 Gene

Unigene Clusters for ACTR3 Gene

ARP3 actin-related protein 3 homolog (yeast):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ACTR3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ACTR3 Gene

No ASD Table

Relevant External Links for ACTR3 Gene

GeneLoc Exon Structure for
ACTR3
ECgene alternative splicing isoforms for
ACTR3

Expression for ACTR3 Gene

mRNA expression in normal human tissues for ACTR3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ACTR3 Gene

This gene is overexpressed in Whole Blood (4.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ACTR3 Gene

SOURCE GeneReport for Unigene cluster for ACTR3 Gene Hs.433512

genes like me logo Genes that share expressions with ACTR3: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ACTR3 Gene

Orthologs for ACTR3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ACTR3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ACTR3 35
  • 99.68 (n)
  • 100 (a)
ACTR3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ACTR3 35
  • 96.33 (n)
  • 100 (a)
ACTR3 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ACTR3B 35
  • 96.73 (n)
  • 100 (a)
ARP3 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Actr3 35
  • 93.46 (n)
  • 99.76 (a)
Actr3 16
Actr3 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ACTR3 36
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Actr3 35
  • 93.3 (n)
  • 99.76 (a)
chicken
(Gallus gallus)
Aves ACTR3 35
  • 88.36 (n)
  • 98.56 (a)
ACTR3 36
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ACTR3 36
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia actr3 35
  • 79.11 (n)
  • 97.37 (a)
zebrafish
(Danio rerio)
Actinopterygii actr3 35
  • 75.6 (n)
  • 97.37 (a)
ACTR3 (1 of 2) 36
  • 97 (a)
OneToMany
ACTR3 (2 of 2) 36
  • 97 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005110 35
  • 68.9 (n)
  • 82.3 (a)
fruit fly
(Drosophila melanogaster)
Insecta Arp3 35
  • 67.3 (n)
  • 80.62 (a)
Arp66B 36
  • 80 (a)
OneToMany
Arp66B 37
  • 80 (a)
worm
(Caenorhabditis elegans)
Secernentea arx-1 35
  • 67.55 (n)
  • 77.22 (a)
arx-1 36
  • 75 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR419C 35
  • 59.75 (n)
  • 64.44 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARP3 35
  • 61.74 (n)
  • 64.53 (a)
ARP3 36
  • 57 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B13904g 35
  • 59.93 (n)
  • 63.55 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.5713 35
bread mold
(Neurospora crassa)
Ascomycetes NCU01756 35
  • 57.7 (n)
  • 64.55 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes arp3 35
  • 60.58 (n)
  • 62.75 (a)
Species with no ortholog for ACTR3:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ACTR3 Gene

ENSEMBL:
Gene Tree for ACTR3 (if available)
TreeFam:
Gene Tree for ACTR3 (if available)

Paralogs for ACTR3 Gene

Paralogs for ACTR3 Gene

genes like me logo Genes that share paralogs with ACTR3: view

Variants for ACTR3 Gene

Sequence variations from dbSNP and Humsavar for ACTR3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs6642 -- 113,957,956(+) CACTC(A/G)TGGGA utr-variant-3-prime, nc-transcript-variant
rs175956 -- 113,924,740(+) TTTTT(C/G)TGTTC intron-variant
rs182176 -- 113,938,302(+) ctgta(G/T)tgttt intron-variant
rs185776 -- 113,928,274(+) atcta(G/T)attcg intron-variant
rs188063 -- 113,943,166(+) GCACA(C/G)GAACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ACTR3 Gene

Variant ID Type Subtype PubMed ID
nsv508860 CNV Insertion 20534489
esv990446 CNV Insertion 20482838

Relevant External Links for ACTR3 Gene

HapMap Linkage Disequilibrium report
ACTR3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACTR3 Gene

Disorders for ACTR3 Gene

(3) Novoseek inferred disease relationships for ACTR3 Gene

Disease -log(P) Hits PubMed IDs
wiskott-aldrich syndrome 87 6
carcinoma 11.5 4
tumors 0 2

Relevant External Links for ACTR3

Genetic Association Database (GAD)
ACTR3
genes like me logo Genes that share disorders with ACTR3: view

No data available for UniProtKB/Swiss-Prot for ACTR3 Gene

Publications for ACTR3 Gene

  1. The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly. (PMID: 9230079) Welch M.D. … Mitchison T.J. (J. Cell Biol. 1997) 2 3 4
  2. The complex containing actin-related proteins Arp2 and Arp3 is required for the motility and integrity of yeast actin patches. (PMID: 9210376) Winter D. … Li R. (Curr. Biol. 1997) 3 23
  3. Mammalian actin-related protein 2/3 complex localizes to regions of lamellipodial protrusion and is composed of evolutionarily conserved proteins. (PMID: 9359840) Machesky L.M. … Segal A.W. (Biochem. J. 1997) 3 23
  4. ARP3beta, the gene encoding a new human actin-related protein, is alternatively spliced and predominantly expressed in brain neuronal cells. (PMID: 10806390) Jay P. … Berta P. (Eur. J. Biochem. 2000) 3 23
  5. Reconstitution of human Arp2/3 complex reveals critical roles of individual subunits in complex structure and activity. (PMID: 11741539) Gournier H. … Welch M.D. (Mol. Cell 2001) 3 4

Products for ACTR3 Gene

  • Addgene plasmids for ACTR3

Sources for ACTR3 Gene

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