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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ACTR3 Gene

protein-coding GIFtS: 57
GCID: GC02P114647

ARP3 actin-related protein 3 homolog (yeast)

(Previous names: ARP3 (actin-related protein 3, yeast) homolog )

Explore 7 diseases affiliated with
ACTR3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
ARP3 Actin-Related Protein 3 Homolog (Yeast)¹ ²
ARP3¹ ² ³ ⁵
Actin-Like Protein 3² ³
ARP3 (Actin-Related Protein 3, Yeast) Homolog¹
Actin-Related Protein 3²

External Ids:	HGNC: 170¹	Entrez Gene: 10096²	Ensembl: ENSG00000115091⁷	OMIM: 604222⁵	UniProtKB: P61158³

Export aliases for ACTR3 gene to outside databases

Previous GC identifers: GC02P111853 GC02P112568 GC02P114554 GC02P114742 GC02P114363 GC02P106964

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ACTR3:

The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a major

constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and

motility through lamellipodial actin assembly and protrusion. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ARP3_HUMAN, P61158

Function: Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin

polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched

actin networks. Seems to contact the pointed end of the daughter actin filament. Plays a role in ciliogenesis

Gene Wiki entry for ACTR3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_022135.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ACTR3 gene promoter:
AML1a POU3F1 POU3F2 (N-Oct-5a) POU3F2 (N-Oct-5b) POU3F2 c-Ets-1 AREB6 Max RSRFC4
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ACTR3 promoter sequence

Search SABiosciences Chromatin IP Primers for ACTR3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ACTR3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q14.1 Ensembl cytogenetic band: 2q14.1 HGNC cytogenetic band: 2q14.1

ACTR3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ACTR3 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P114647: view genomic region (about GC identifiers)

Start:	114,647,537 bp from pter	End:	114,720,173 bp from pter
Size:	72,637 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ARP3_HUMAN, P61158 (See protein sequence)

Recommended Name: Actin-related protein 3

Size: 418 amino acids; 47371 Da

Subunit: Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC,

ARPC4/p20-ARC and ARPC5/p16-ARC. Interacts with WHDC1

Subcellular location: Cytoplasm, cytoskeleton. Cell projection

Secondary accessions: P32391 Q53QM2

Explore the universe of human proteins at neXtProt for ACTR3: NX_P61158

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P61158

ACTR3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_005712.1

ENSEMBL proteins:

ENSP00000263238 ENSP00000403125 ENSP00000407912 ENSP00000394213 ENSP00000445257

ENSP00000444987

Reactome Protein details: P61158
Human Recombinant Protein Products for ACTR3:

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	Novus Biologicals ACTR3 Protein Novus Biologicals ACTR3 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for ACTR3

Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000139	Golgi membrane	IEA	--
GO:0002102	podosome	IEA	--
GO:0005737	cytoplasm	--	--
GO:0005856	cytoskeleton	--	--
GO:0005884	actin filament	--	--

ACTR3 for ontologies About GeneDecksing

ACTR3 Antibody Products:

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	ThermoFisher Antibodies for ACTR3

Assay Products for ACTR3:

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	GenScript Custom Assay Services for ACTR3
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for ACTR3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ACTR3 for domains About GeneDecksing

3 InterPro domains/families:

IPR015623 Arp3

IPR004000 Actin-related

IPR020902 Actin/actin-like_CS

Graphical View of Domain Structure for InterPro Entry P61158

ProtoNet protein and cluster: P61158

UniProtKB/Swiss-Prot: ARP3_HUMAN, P61158

Similarity: Belongs to the actin family. ARP3 subfamily

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: ARP3_HUMAN, P61158

Function: Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin

polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched

actin networks. Seems to contact the pointed end of the daughter actin filament. Plays a role in ciliogenesis

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003779	actin binding	IEA	--
GO:0005515	protein binding	IPI	--
GO:0005524	ATP binding	IEA	--

ACTR3 for ontologies About GeneDecksing

Phenotypes:
9 GenomeRNAi human phenotypes for ACTR3:

Decreased Salmonella enterica	Decreased Salmonella enterica	Decreased Salmonella enterica	Decreased Salmonella enterica
Decreased Salmonella enterica	Decreased Salmonella-containin	Decreased focal adhesion (FA)	Increased cilium length
Increased cilium length after

2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Actr3):

embryogenesis

mortality/aging

ACTR3 for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ACTR3

miRNA Products:		OriGene 3'-UTR Clone: ACTR3 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ACTR3
		8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate ACTR3 (see all 12):
		hsa-miR-3671 hsa-miR-607 hsa-miR-429 hsa-miR-1261 hsa-miR-340 hsa-miR-3133 hsa-miR-548l hsa-miR-511

		SwitchGear 3'UTR luciferase reporter plasmid: ACTR3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ACTR3 (see all 7) OriGene shRNA RFP: ACTR3 OriGene siRNA: ACTR3
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		Sirion Biotech Custom design and validation of potent shRNA sequences against ACTR3

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for ACTR3
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ACTR3 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ACTR3 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ACTR3 (NM_005721)
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACTR3

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/26 super-pathways (see all 26) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Cell adhesion_Integrin-mediated cell adhesion and migration

Cell adhesion_Integrin-mediated cell adhesion and migration	1.00	Cytoskeleton remodeling_Integrin outside-in signaling	0.37
Cell adhesion Integrin-mediated cell adhesion and migration	1.00	Cytoskeleton remodeling Integrin outside-in signaling	0.37
Cytoskeleton remodeling_Regulation of actin cytoskeleton by Rho GTPases	0.49	Cytoskeleton remodeling Fibronectin-binding integrins in cell motility	0.32
Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases	0.49	Cytoskeleton remodeling_Fibronectin-binding integrins in cell motility	0.32

G-protein signaling_RAC1 in cellular process

G-protein signaling_RAC1 in cellular process	1.00	Cytoskeleton remodeling CDC42 in cellular processes	0.37
G-protein signaling RAC1 in cellular process	1.00	RAC1 signaling pathway	0.34
Cytoskeleton remodeling_CDC42 in cellular processes	0.37	CDC42 signaling events	0.17

Regulation of actin dynamics for phagocytic cup formation

	Regulation of actin dynamics for phagocytic cup formation	1.00			Fcgamma receptor (FCGR) dependent phagocytosis	0.80
	Role of myosins in phagosome formation	0.80			Branching and elongation of mother and daughter filaments	0.29

Cytoskeleton remodeling Slit-Robo signaling

	Cytoskeleton remodeling Slit-Robo signaling	1.00			Cell adhesion_Cadherin-mediated cell adhesion	0.28
	Development_Slit-Robo signaling	0.92			Cell adhesion Cadherin-mediated cell adhesion	0.28

Immune response CD16 signaling in NK cells

	Immune response CD16 signaling in NK cells	1.00			Immune response_Role of DAP12 receptors in NK cells	0.32
	Immune response_CD16 signaling in NK cells	0.99			Immune response Role of DAP12 receptors in NK cells	0.32

Pathway sources
See GeneCards unified pathways
Show all pathways

5/13 EMD Millipore Pathways for ACTR3 (see all 13)

	Cytoskeleton remodeling Integrin outside-in signaling
	Immune response CD16 signaling in NK cells
	Cytoskeleton remodeling CDC42 in cellular processes
	Cytoskeleton remodeling Fibronectin-binding integrins in cell motility
	Immune response Role of DAP12 receptors in NK cells

5/20 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ACTR3 (see all 20)

	RhoA Pathway
	Actin-Based Motility by Rho Family GTPases
	Remodeling of Adherens Junctions
	Guidance Cues and Growth Cone Motility
	Signaling by Slit

1 Cell Signaling Technology (CST) Pathway for ACTR3

Cytoskeletal Signaling

5/14 GeneGo (Thomson Reuters) Pathways for ACTR3 (see all 14)

	Cytoskeleton remodeling CDC42 in cellular processes
	Immune response CD16 signaling in NK cells
	Cytoskeleton remodeling Fibronectin-binding integrins in cell motility
	Neurophysiological process Receptor-mediated axon growth repulsion
	Cytoskeleton remodeling Integrin outside-in signaling

4 BioSystems Pathways for ACTR3

	B Cell Receptor Signaling Pathway
	RAC1 signaling pathway
	ErbB1 downstream signaling
	CDC42 signaling events

5/6 Reactome Pathways for ACTR3 (see all 6)

	Role of myosins in phagosome formation
	Branching and elongation of mother and daughter filaments
	Regulation of actin dynamics for phagocytic cup formation
	Fcgamma receptor (FCGR) dependent phagocytosis
	Immune System

ACTR3 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for ACTR3

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/105 Interacting proteins for ACTR3 (P61158^{1, 3} ENSP00000263238⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 105)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
JUND	P17535¹^,³	EBI-351428,EBI-2682803 I2D: score=1
ACTR2	P61160³, ENSP00000367220⁴	I2D: score=6 STRING: ENSP00000367220
CTTN	Q14247³, ENSP00000301843⁴	I2D: score=3 STRING: ENSP00000301843
WASF3	Q9UPY6³, ENSP00000335055⁴	I2D: score=3 STRING: ENSP00000335055
EIF1B	O60739³, ENSP00000232905⁴	I2D: score=2 STRING: ENSP00000232905

About this table

Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006928	cellular component movement	TAS	9230079
GO:0007163	establishment or maintenance of cell polarity	IEA	--
GO:0008356	asymmetric cell division	IEA	--
GO:0009743	response to carbohydrate stimulus	IEA	--
GO:0010592	positive regulation of lamellipodium assembly	IEA	--

ACTR3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

ACTR3 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ACTR3

2 DrugBank Compounds for ACTR3 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
(2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one	--	--	target	--	10592235
N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide	--	--	target	--	10592235

2 Novoseek chemical compound relationships for ACTR3 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	24	1	16912177 (1)
phosphatidylinositol	10.7	2	11694514 (1)

Search CenterWatch for drugs/clinical trials and news about ACTR3 / ARP3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ACTR3 gene:

NM_005721.3

Unigene Cluster for ACTR3:

ARP3 actin-related protein 3 homolog (yeast)

Hs.433512 [show with all ESTs]

Unigene Representative Sequence: BC044590

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000263238(uc002tkx.1 uc010yyc.1 uc010yyd.1) ENST00000443297

ENST00000415792 ENST00000446821 ENST00000489779 ENST00000484165 ENST00000478928

ENST00000536059 ENST00000535589

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ACTR3
		8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate ACTR3 (see all 12):
		hsa-miR-3671 hsa-miR-607 hsa-miR-429 hsa-miR-1261 hsa-miR-340 hsa-miR-3133 hsa-miR-548l hsa-miR-511

		SwitchGear 3'UTR luciferase reporter plasmid: ACTR3 3' UTR sequence

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		Sirion Biotech Custom design and validation of potent shRNA sequences against ACTR3

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		GenScript: all cDNA clones in your preferred vector: ACTR3 (NM_005721)
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ACTR3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ACTR3

Additional cDNA sequence:

AB209353.1 AF006083.1 AF127773.1 AK300030.1 AK300224.1 AK302152.1 AK302359.1 AK303988.1

AK312659.1 AK316213.1 AK316396.1 BC044590.1

24/25 DOTS entries (see all 25):

DT.418993 DT.95151555 DT.95082634 DT.40106744 DT.100825760 DT.101976946 DT.120943942 DT.120943924

DT.95264748 DT.120943855 DT.120943931 DT.100825759 DT.100825768 DT.120943892 DT.120943901 DT.121462832

DT.40190993 DT.97831938 DT.99950190 DT.100825755 DT.75161379 DT.92456023 DT.95310888 DT.92456021

24/669 AceView cDNA sequences (see all 669):

AI380021 BM467835 BQ650986 AI497739 BM834447 BE792331 BQ227570 BU173208

CR601900 AW662361 BP365931 AU126443 D57546 BM803775 AW662090 AA382722

CA391178 AL044915 BQ654376 D57545 AA252183 AU118717 AI828414 BX105214

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ACTR3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGACTTGGCA

About this image

ACTR3 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Kidney

Metanephric Mesenchyme

Metanephric Mesenchyme Cells

Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

PureStem™ progenitor E69 (Embryonic Progenitor Cell)

PureStem™ progenitor T36 (Embryonic Progenitor Cell)

See ACTR3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ACTR3

SOURCE GeneReport for Unigene cluster: Hs.433512

SABiosciences Expression via Pathway-Focused PCR Arrays including ACTR3:

Cytoskeleton Regulators in human mouse rat

Cell Motility in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ACTR3

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACTR3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for ACTR3 gene from 9/35 species (see all 35) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	ACTR3¹	ARP3 actin-related protein 3 homolog (yeast)	88.36(n) 98.56(a)		374197 NM_204307.1 NP_989638.1
lizard (Anolis carolinensis)	Reptilia	ACTR3⁶	--	96(a)	1 ↔ 1	1(80435350-80464445)
African clawed frog (Xenopus laevis)	Amphibia	BC047983.1²	--	81.86(n)		BC047983.1
zebrafish (Danio rerio)	Actinopterygii	actr3¹	ARP3 actin-related protein 3 homolog (yeast)	75.6(n) 97.37(a)		406250 NM_001003944.1 NP_001003944.1
fruit fly (Drosophila melanogaster)	Insecta	Arp66B^{1 , 3}	cell cycle dependent actin filament reorganization more³ Actin-related protein 66B¹	80(a)³ 67.3(n)¹ 80.62(a)¹		66B6³ 38898¹ NM_079244.2¹ NP_523968.1¹
worm (Caenorhabditis elegans)	Secernentea	arx-1¹	Protein ARX-1	67.55(n) 77.22(a)		171857 NM_058665.3 NP_491066.1
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	ARP3¹	Arp3p	61.33(n) 64.29(a)		853528 NP_012599.3
thale cress (Arabidopsis thaliana)	eudicotyledons	ARP3⁶ ATARP7⁶ (see all 3)	actin-related protein 7 (see all 3)	58(a) 28(a) (see all 3)	1 ↔ many possible ortholog (see all 3)	1(4495028-4498469) 3(22474074-22476445)
rice (Oryza sativa)	Liliopsida	AK101163.1²	--	69.61(n)		AK101163.1

ENSEMBL Gene Tree for ACTR3 (if available)
TreeFam Gene Tree for ACTR3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for ACTR3 gene

ACTR3C² ACTR10² ACTR3B²

18/27 SIMAP similar genes for ACTR3 using alignment to 6 protein entries: ARP3_HUMAN (see all proteins) (see all similar genes):

ACTR3B ACTR3C FKSG72 FKSG73 FKSG74 ACTL6B

ACT ACTB ACTR1B ACTA2 ACTR1A ACTR2

ACTBL2 PS1TP5BP1 ACTC1 ACTG1 ACTG2 POTEI

ACTR3 for paralogs About GeneDecksing

5 Pseudogenes.org Pseudogenes for ACTR3
PGOHUM00000247736 PGOHUM00000260093 PGOHUM00000260292 PGOHUM00000236760 PGOHUM00000241828

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs35758303^1,2	C	--	107030112(+)	`TCATT-/TGATTC`	1	--	int¹		3		NA CSA	6
rs181816359^1,2		--	114645546(+)	`AAAACA/CACCTC`	1	--	us2k¹		0	--	--	--	--
rs139621251^1,2		--	114645627(+)	`AGTCTC/TCTCTG`	1	--	us2k¹		0	--	--	--	--
rs77734721^1,2	F	--	114645637(+)	`GCACAT/CACCTG`	1	--	us2k¹		1		NA	120
rs187291929^1,2		--	114645688(+)	`AACTCC/TGGAAC`	1	--	us2k¹		0	--	--	--	--
rs190485705^1,2		--	114645703(+)	`AATATC/GATACA`	1	--	us2k¹		0	--	--	--	--
rs77303665^1,2	C	--	114645708(+)	`CATACA/GATGTA`	1	--	us2k¹		2		CSA EA	122
rs142848644^1,2		--	114645953(+)	`TTTCAC/TATGGA`	1	--	us2k¹		0	--	--	--	--
rs117743292^1,2		--	114646037(+)	`GGGAGA/TCTCTT`	1	--	us2k¹		1		EA	120
rs180820817^1,2		--	114646215(+)	`GAGCAC/TTTAAC`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ACTR3 (114647537 - 114720173 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ACTR3: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ACTR3

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ACTR3 for disorders           About GeneDecksing

OMIM gene information: 604222    OMIM disorders: --

7 diseases for ACTR3:    About MalaCards

wiskott-aldrich syndrome vaccinia gastric cancer breast cancer

carcinoma hepatitis neuronitis

3 Novoseek disease relationships for ACTR3 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
wiskott-aldrich syndrome	87	7	11694514 (1), 15800060 (1), 16246088 (1), 16682943 (1) (see all 6)
carcinoma	11.5	5	18751399 (3), 14990971 (1)
tumors	0	2	16912177 (1), 14990971 (1)

Export disorders for ACTR3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for ACTR3 gene, integrated from 9 sources (see all 124):
(articles sorted by number of sources associating them with ACTR3)

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world of online information

The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly. (PubMed id 9230079)^{1, 2, 3} Welch M.D.... Mitchison T.J. (1997)
Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)^{1, 2} Rush J.... Comb M.J. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Reconstitution of human Arp2/3 complex reveals critical roles of individual subunits in complex structure and activity. (PubMed id 11741539)^{1, 2} Gournier H.... Welch M.D. (2001)
Actin polymerization is induced by Arp2/3 protein complex at the surface of Listeria monocytogenes. (PubMed id 9000076)^{1, 2} Welch M.D.... Mitchison T.J. (1997)
Interaction of cortactin and N-WASp with Arp2/3 complex. (PubMed id 12176354)^{1, 9} Weaver A.M....Cooper J.A. (2002)
The complex containing actin-related proteins Arp2 and Arp3 is required for the motility and integrity of yeast actin patches. (PubMed id 9210376)^{1, 9} Winter D....Li R. (1997)
ARP3beta, the gene encoding a new human actin-related protein, is alternatively spliced and predominantly expressed in brain neuronal cells. (PubMed id 10806390)^{1, 9} Jay P.... Berta P. (2000)
Osmotic stress-induced remodeling of the cortical cytoskeleton. (PubMed id 12176742)^{1, 9} Di Ciano C....Kapus A. (2002)
Integration of multiple signals through cooperative regulation of the N-WASP-Arp2/3 complex. (PubMed id 11052943)^{1, 9} Prehoda K.E....Lim W.A. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 10096	HGNC: 170	AceView: ACTR3	Ensembl:ENSG00000115091	euGenes: HUgn10096
ECgene: ACTR3	H-InvDB: ACTR3

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ACTR3	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ACTR3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for ACTR3 gene:
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GeneCards and IP:
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ARP3 actin-related protein 3 homolog (yeast)

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ARP3 actin-related protein 3 homolog (yeast)

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