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Aliases for ACTR3 Gene

Aliases for ACTR3 Gene

  • ARP3 Actin-Related Protein 3 Homolog (Yeast) 2 3 5
  • Actin-Like Protein 3 3 4
  • ARP3 3 4
  • ARP3 (Actin-Related Protein 3, Yeast) Homolog 2

External Ids for ACTR3 Gene

Previous GeneCards Identifiers for ACTR3 Gene

  • GC02P111853
  • GC02P112568
  • GC02P114554
  • GC02P114742
  • GC02P114363
  • GC02P114647
  • GC02P106964

Summaries for ACTR3 Gene

Entrez Gene Summary for ACTR3 Gene

  • The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and motility through lamellipodial actin assembly and protrusion. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Mar 2013]

GeneCards Summary for ACTR3 Gene

ACTR3 (ARP3 Actin-Related Protein 3 Homolog (Yeast)) is a Protein Coding gene. Diseases associated with ACTR3 include wiskott-aldrich syndrome. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases. GO annotations related to this gene include actin filament binding and structural constituent of cytoskeleton. An important paralog of this gene is ACTR3B.

UniProtKB/Swiss-Prot for ACTR3 Gene

  • Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament. Plays a role in ciliogenesis.

Gene Wiki entry for ACTR3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACTR3 Gene

Genomics for ACTR3 Gene

Regulatory Elements for ACTR3 Gene

Promoters for ACTR3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ACTR3 on UCSC Golden Path with GeneCards custom track

Genomic Location for ACTR3 Gene

Chromosome:
2
Start:
113,889,934 bp from pter
End:
113,962,596 bp from pter
Size:
72,663 bases
Orientation:
Plus strand

Genomic View for ACTR3 Gene

Genes around ACTR3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACTR3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACTR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACTR3 Gene

Proteins for ACTR3 Gene

  • Protein details for ACTR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61158-ARP3_HUMAN
    Recommended name:
    Actin-related protein 3
    Protein Accession:
    P61158
    Secondary Accessions:
    • P32391
    • Q53QM2

    Protein attributes for ACTR3 Gene

    Size:
    418 amino acids
    Molecular mass:
    47371 Da
    Quaternary structure:
    • Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC. Interacts with WHDC1. Interacts weakly with MEFV.

neXtProt entry for ACTR3 Gene

Proteomics data for ACTR3 Gene at MOPED

Post-translational modifications for ACTR3 Gene

  • Ubiquitination at Lys 38, Lys 69, Lys 75, Lys 99, Lys 191, Lys 251, Lys 254, Lys 265, Lys 317, Lys 348, and Lys 359
  • Modification sites at PhosphoSitePlus

Other Protein References for ACTR3 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ACTR3 (Arp3)

No data available for DME Specific Peptides for ACTR3 Gene

Domains & Families for ACTR3 Gene

Gene Families for ACTR3 Gene

Protein Domains for ACTR3 Gene

Graphical View of Domain Structure for InterPro Entry

P61158

UniProtKB/Swiss-Prot:

ARP3_HUMAN :
  • Belongs to the actin family. ARP3 subfamily.
Family:
  • Belongs to the actin family. ARP3 subfamily.
genes like me logo Genes that share domains with ACTR3: view

Function for ACTR3 Gene

Molecular function for ACTR3 Gene

UniProtKB/Swiss-Prot Function:
Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament. Plays a role in ciliogenesis.

Gene Ontology (GO) - Molecular Function for ACTR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051015 contributes_to actin filament binding IDA 11741539
genes like me logo Genes that share ontologies with ACTR3: view
genes like me logo Genes that share phenotypes with ACTR3: view

Animal Model Products

CRISPR Products

miRNA for ACTR3 Gene

miRTarBase miRNAs that target ACTR3

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ACTR3 Gene

Localization for ACTR3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACTR3 Gene

Cytoplasm, cytoskeleton. Cell projection. Note=In pre-apoptotic cells, colocalizes with MEFV in large specks (pyroptosomes) (PubMed:19109554).

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ACTR3 Gene COMPARTMENTS Subcellular localization image for ACTR3 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
extracellular 5
nucleus 2
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ACTR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005925 focal adhesion IDA 21423176
GO:0016020 membrane IDA 19946888
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with ACTR3: view

Pathways & Interactions for ACTR3 Gene

genes like me logo Genes that share pathways with ACTR3: view

Gene Ontology (GO) - Biological Process for ACTR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006928 movement of cell or subcellular component TAS 9230079
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0007411 axon guidance TAS --
GO:0033206 meiotic cytokinesis IEA --
GO:0034314 Arp2/3 complex-mediated actin nucleation IEA,IDA 11741539
genes like me logo Genes that share ontologies with ACTR3: view

No data available for SIGNOR curated interactions for ACTR3 Gene

Drugs & Compounds for ACTR3 Gene

(3) Drugs for ACTR3 Gene - From: Novoseek and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
(2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one Experimental Pharma Target 0
N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide Experimental Pharma Target 0

(1) Additional Compounds for ACTR3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ACTR3: view

Transcripts for ACTR3 Gene

Unigene Clusters for ACTR3 Gene

ARP3 actin-related protein 3 homolog (yeast):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ACTR3 Gene

No ASD Table

Relevant External Links for ACTR3 Gene

GeneLoc Exon Structure for
ACTR3
ECgene alternative splicing isoforms for
ACTR3

Expression for ACTR3 Gene

mRNA expression in normal human tissues for ACTR3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ACTR3 Gene

This gene is overexpressed in Whole Blood (x4.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ACTR3 Gene



SOURCE GeneReport for Unigene cluster for ACTR3 Gene Hs.433512

genes like me logo Genes that share expression patterns with ACTR3: view

Protein tissue co-expression partners for ACTR3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ACTR3 Gene

Orthologs for ACTR3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ACTR3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ACTR3 35
  • 96.33 (n)
  • 100 (a)
ACTR3 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ACTR3B 35
  • 96.73 (n)
  • 100 (a)
ARP3 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Actr3 35
  • 93.46 (n)
  • 99.76 (a)
Actr3 16
Actr3 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ACTR3 35
  • 99.68 (n)
  • 100 (a)
ACTR3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Actr3 35
  • 93.3 (n)
  • 99.76 (a)
oppossum
(Monodelphis domestica)
Mammalia ACTR3 36
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves ACTR3 35
  • 88.36 (n)
  • 98.56 (a)
ACTR3 36
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ACTR3 36
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia actr3 35
  • 79.11 (n)
  • 97.37 (a)
zebrafish
(Danio rerio)
Actinopterygii actr3 35
  • 75.6 (n)
  • 97.37 (a)
ACTR3 (1 of 2) 36
  • 97 (a)
OneToMany
ACTR3 (2 of 2) 36
  • 97 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Arp66B 37
  • 80 (a)
Arp3 35
  • 67.3 (n)
  • 80.62 (a)
Arp66B 36
  • 80 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005110 35
  • 68.9 (n)
  • 82.3 (a)
worm
(Caenorhabditis elegans)
Secernentea arx-1 35
  • 67.55 (n)
  • 77.22 (a)
arx-1 36
  • 75 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR419C 35
  • 59.75 (n)
  • 64.44 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B13904g 35
  • 59.93 (n)
  • 63.55 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARP3 35
  • 61.74 (n)
  • 64.53 (a)
ARP3 36
  • 57 (a)
OneToMany
barley
(Hordeum vulgare)
Liliopsida Hv.5713 35
bread mold
(Neurospora crassa)
Ascomycetes NCU01756 35
  • 57.7 (n)
  • 64.55 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes arp3 35
  • 60.58 (n)
  • 62.75 (a)
Species with no ortholog for ACTR3:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ACTR3 Gene

ENSEMBL:
Gene Tree for ACTR3 (if available)
TreeFam:
Gene Tree for ACTR3 (if available)

Paralogs for ACTR3 Gene

Paralogs for ACTR3 Gene

genes like me logo Genes that share paralogs with ACTR3: view

Variants for ACTR3 Gene

Sequence variations from dbSNP and Humsavar for ACTR3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs185776 -- 113,928,274(+) atcta(G/T)attcg intron-variant
rs6642 -- 113,957,956(+) CACTC(A/G)TGGGA nc-transcript-variant, utr-variant-3-prime
rs188063 -- 113,943,166(+) GCACA(C/G)GAACA intron-variant
rs189735 -- 113,928,540(+) gagca(C/G)atagc intron-variant
rs190693 -- 113,953,311(+) tacca(A/G)aagtg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ACTR3 Gene

Variant ID Type Subtype PubMed ID
nsv508860 CNV Insertion 20534489
esv990446 CNV Insertion 20482838

Variation tolerance for ACTR3 Gene

Residual Variation Intolerance Score: 29.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.08; 21.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ACTR3 Gene

HapMap Linkage Disequilibrium report
ACTR3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACTR3 Gene

Disorders for ACTR3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ACTR3 Gene - From: Novoseek and GeneCards

Disorder Aliases PubMed IDs
wiskott-aldrich syndrome
  • wiskott syndrome
- elite association - COSMIC cancer census association via MalaCards
Search ACTR3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ACTR3

Genetic Association Database (GAD)
ACTR3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ACTR3
genes like me logo Genes that share disorders with ACTR3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ACTR3 Gene

Publications for ACTR3 Gene

  1. The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly. (PMID: 9230079) Welch M.D. … Mitchison T.J. (J. Cell Biol. 1997) 2 3 4 67
  2. Interaction of cortactin and N-WASp with Arp2/3 complex. (PMID: 12176354) Weaver A.M. … Cooper J.A. (Curr. Biol. 2002) 3 23
  3. Osmotic stress-induced remodeling of the cortical cytoskeleton. (PMID: 12176742) Di Ciano C. … Kapus A. (Am. J. Physiol., Cell Physiol. 2002) 3 23
  4. ARP3beta, the gene encoding a new human actin-related protein, is alternatively spliced and predominantly expressed in brain neuronal cells. (PMID: 10806390) Jay P. … Berta P. (Eur. J. Biochem. 2000) 3 23
  5. Integration of multiple signals through cooperative regulation of the N-WASP-Arp2/3 complex. (PMID: 11052943) Prehoda K.E. … Lim W.A. (Science 2000) 3 23

Products for ACTR3 Gene

Sources for ACTR3 Gene

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