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ACTR3 Gene

protein-coding   GIFtS: 61
GCID: GC02P114647

ARP3 Actin-Related Protein 3 Homolog (Yeast)

(Previous names: ARP3 (actin-related protein 3, yeast) homolog)
  Search for ACTR3
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ARP3 Actin-Related Protein 3 Homolog (Yeast)1 2
ARP32 3 5
Actin-Like Protein 32 3
ARP3 (Actin-Related Protein 3, Yeast) Homolog1
Actin-Related Protein 32

External Ids:    HGNC: 1701   Entrez Gene: 100962   Ensembl: ENSG000001150917   OMIM: 6042225   UniProtKB: P611583   

Export aliases for ACTR3 gene to outside databases

Previous GC identifers: GC02P111853 GC02P112568 GC02P114554 GC02P114742 GC02P114363 GC02P106964


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ACTR3 Gene:
The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a
major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell
shape and motility through lamellipodial actin assembly and protrusion. Three transcript variants encoding two
different isoforms have been found for this gene. (provided by RefSeq, Mar 2013)

GeneCards Summary for ACTR3 Gene:
ACTR3 (ARP3 actin-related protein 3 homolog (yeast)) is a protein-coding gene. GO annotations related to this gene include actin binding. An important paralog of this gene is ACTR3C.

UniProtKB/Swiss-Prot: ARP3_HUMAN, P61158
Function: Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin
polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of
branched actin networks. Seems to contact the pointed end of the daughter actin filament. Plays a role in
ciliogenesis

Gene Wiki entry for ACTR3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_005403.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the ACTR3 gene promoter:
         AML1a   POU3F1   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   c-Ets-1   AREB6   Max   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidACTR3 promoter sequence
   Search Chromatin IP Primers for ACTR3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ACTR3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q14.1   Ensembl cytogenetic band:  2q14.1   HGNC cytogenetic band: 2q14.1

ACTR3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ACTR3 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P114647:  view genomic region     (about GC identifiers)

Start:
114,647,537 bp from pter      End:
114,720,173 bp from pter
Size:
72,637 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ARP3_HUMAN, P61158 (See protein sequence)
Recommended Name: Actin-related protein 3  
Size: 418 amino acids; 47371 Da
Subunit: Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC,
ARPC4/p20-ARC and ARPC5/p16-ARC. Interacts with WHDC1. Interacts weakly with MEFV
Secondary accessions: P32391 Q53QM2

Explore the universe of human proteins at neXtProt for ACTR3: NX_P61158

Explore proteomics data for ACTR3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys38, Lys53, Lys69, Lys75, Lys99, Lys191, Lys240, Lys251, Lys254, Lys265,
                                 Lys317, Lys348, Lys359, Lys361
  • Modification sites at PhosphoSitePlus

  • See ACTR3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001264069.1  NP_005712.1  

    ENSEMBL proteins: 
     ENSP00000263238   ENSP00000403125   ENSP00000407912   ENSP00000394213   ENSP00000444987  
     ENSP00000445257  
    Reactome Protein details: P61158

    ACTR3 Human Recombinant Protein Products:

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    Novus Biologicals ACTR3 Protein
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    Cloud-Clone Corp. Proteins for ACTR3

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR020902 Actin/actin-like_CS
     IPR004000 Actin-related

    Graphical View of Domain Structure for InterPro Entry P61158

    ProtoNet protein and cluster: P61158

    UniProtKB/Swiss-Prot: ARP3_HUMAN, P61158
    Similarity: Belongs to the actin family. ARP3 subfamily


    Find genes that share domains with ACTR3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ARP3_HUMAN, P61158
    Function: Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin
    polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of
    branched actin networks. Seems to contact the pointed end of the daughter actin filament. Plays a role in
    ciliogenesis

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IEA--
         
    Find genes that share ontologies with ACTR3           About GenesLikeMe


    Phenotypes:
         9 GenomeRNAi human phenotypes for ACTR3:
     Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella enterica  
     Decreased Salmonella enterica   Decreased Salmonella-containin  Decreased focal adhesion (FA)   Increased cilium length 
     Increased cilium length after  

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Actr3):
     embryogenesis  mortality/aging 

    Find genes that share phenotypes with ACTR3           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ACTR3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ACTR3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ACTR3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ACTR3

    miRNA
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    miRTarBase miRNAs that target ACTR3:
    hsa-mir-124-3p (MIRT022726)

    Block miRNA regulation of human, mouse, rat ACTR3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ACTR3 (see all 12):
    hsa-miR-3671 hsa-miR-607 hsa-miR-429 hsa-miR-1261 hsa-miR-340 hsa-miR-3133 hsa-miR-548l hsa-miR-511
    SwitchGear 3'UTR luciferase reporter plasmidACTR3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ACTR3

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: ACTR3 (NM_005721)
    Sino Biological Human cDNA Clone for ACTR3
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACTR3
    Addgene plasmids for ACTR3 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACTR3

    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-12089) for ACTR3 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ARP3_HUMAN, P61158: Cytoplasm, cytoskeleton. Cell projection. Note=In pre-apoptotic cells, colocalizes with MEFV
    in large specks (pyroptosomes)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol4
    golgi apparatus2
    nucleus2
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0002102podosome IEA--
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--
    GO:0005885Arp2/3 protein complex TAS9230079

    Find genes that share ontologies with ACTR3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ACTR3 About   (see all 26)  
    See pathways by source

    SuperPathContained pathways About
    1Development Slit Robo signaling
    Development Slit Robo signaling0.92
    Neurophysiological process Receptor mediated axon growth repulsion0.41
    Cytoskeleton remodeling Slit Robo signaling0.92
    2Immune response CCR3 signaling in eosinophils
    Inhibitory action of Lipoxins on neutrophil migration0.51
    Immune response CCR3 signaling in eosinophils0.51
    3Actin Nucleation by ARP-WASP Complex
    Actin Nucleation and Branching0.66
    CDC42 Pathway0.41
    Actin Nucleation by ARP-WASP Complex0.66
    RhoA Pathway0.35
    4Cell adhesion Integrin mediated cell adhesion and migration
    Cell adhesion Integrin mediated cell adhesion and migration0.49
    Cytoskeleton remodeling Integrin outside in signaling0.37
    Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases0.49
    Cytoskeleton remodeling Fibronectin binding integrins in cell motility0.32
    5Fcgamma receptor (FCGR) dependent phagocytosis
    Regulation of actin dynamics for phagocytic cup formation0.77
    Fcgamma receptor (FCGR) dependent phagocytosis0.77


    Find genes that share SuperPaths with ACTR3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ACTR3 (see all 20)
        RhoA Pathway
    Actin-Based Motility by Rho Family GTPases
    Remodeling of Adherens Junctions
    Guidance Cues and Growth Cone Motility
    Signaling by Slit

    1 Cell Signaling Technology (CST) Pathway for ACTR3
        Cytoskeletal Signaling

    Selected GeneGo (Thomson Reuters) Pathways for ACTR3 (see all 14)
        Cytoskeleton remodeling CDC42 in cellular processes
    Immune response CD16 signaling in NK cells
    Cytoskeleton remodeling Fibronectin-binding integrins in cell motility
    Neurophysiological process Receptor-mediated axon growth repulsion
    Cytoskeleton remodeling Integrin outside-in signaling

    4 BioSystems Pathways for ACTR3
        B Cell Receptor Signaling Pathway
    CDC42 signaling events
    ErbB1 downstream signaling
    RAC1 signaling pathway


    1 Reactome Pathway for ACTR3
        Regulation of actin dynamics for phagocytic cup formation


        Pathway & Disease-focused RT2 Profiler PCR Arrays including ACTR3: 
              Cytoskeleton Regulators in human mouse rat
              Cell Motility in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ACTR3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ACTR3 (P611581, 3 ENSP000002632384) via UniProtKB, MINT, STRING, and/or I2D (see all 188)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    JUNDP175351, 3EBI-351428,EBI-2682803 I2D: score=1 
    ACTR2P611603, ENSP000003672204I2D: score=6 STRING: ENSP00000367220
    CTTNQ142473, ENSP000003018434I2D: score=3 STRING: ENSP00000301843
    WASF3Q9UPY63, ENSP000003350554I2D: score=3 STRING: ENSP00000335055
    EIF1BO607393, ENSP000002329054I2D: score=2 STRING: ENSP00000232905
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    Gene Ontology (GO): Selected biological process terms (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006928cellular component movement TAS9230079
    GO:0007163establishment or maintenance of cell polarity IEA--
    GO:0008356asymmetric cell division IEA--
    GO:0009743response to carbohydrate IEA--
    GO:0010592positive regulation of lamellipodium assembly IEA--

    Find genes that share ontologies with ACTR3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ACTR3 (ARP3)

    2 DrugBank Compounds for ACTR3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one-- --target--10592235
    N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide-- --target--10592235

    2 Novoseek inferred chemical compound relationships for ACTR3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 24 1 16912177 (1)
    phosphatidylinositol 10.7 2 11694514 (1)



    Find genes that share compounds with ACTR3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ACTR3 gene (2 alternative transcripts): 
    NM_001277140.1  NM_005721.4  

    Unigene Cluster for ACTR3:

    ARP3 actin-related protein 3 homolog (yeast)
    Hs.433512  [show with all ESTs]
    Unigene Representative Sequence: BC044590
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000263238(uc002tkx.1 uc010yyc.1 uc010yyd.1) ENST00000443297
    ENST00000415792 ENST00000446821 ENST00000535589 ENST00000489779 ENST00000484165
    ENST00000478928 ENST00000536059
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ACTR3 (see all 12):
    hsa-miR-3671 hsa-miR-607 hsa-miR-429 hsa-miR-1261 hsa-miR-340 hsa-miR-3133 hsa-miR-548l hsa-miR-511
    SwitchGear 3'UTR luciferase reporter plasmidACTR3 3' UTR sequence
    Inhib. RNA
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    Addgene plasmids for ACTR3 
    Primer
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    Additional mRNA sequence: 

    AB209353.1 AF006083.1 AF127773.1 AK300030.1 AK300224.1 AK302152.1 AK302359.1 AK303988.1 
    AK312659.1 AK316213.1 AK316396.1 BC044590.1 

    Selected DOTS entries (see all 25):

    DT.418993  DT.95151555  DT.95082634  DT.40106744  DT.100825760  DT.101976946  DT.120943942  DT.120943924 
    DT.95264748  DT.120943855  DT.120943931  DT.100825759  DT.100825768  DT.120943892  DT.120943901  DT.121462832 
    DT.40190993  DT.97831938  DT.99950190  DT.100825755  DT.75161379  DT.92456023  DT.95310888  DT.92456021 

    Selected AceView cDNA sequences (see all 669):

    BM981068 CB136826 CB850944 T33931 BE242134 AA382722 BM696920 AI819801 
    AI927012 AW512387 BM995764 NM_005721 BU158683 AA575967 AA865092 BM834447 
    AI685240 BX953030 CR620086 BE889991 CA309946 AI621346 D57545 AI828414 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    ACTR3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGACTTGGCA
    ACTR3 Expression
    About this image


    ACTR3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 18) fully expand
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Intermediate Mesoderm (Gastrulation Derivatives)
             Intermediate Mesoderm
     
     Colon (Gastrointestinal Tract)
     
     Uterus (Reproductive System)
    ACTR3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ACTR3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.433512
        Pathway & Disease-focused RT2 Profiler PCR Arrays including ACTR3: 
              Cytoskeleton Regulators in human mouse rat
              Cell Motility in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat ACTR3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACTR3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ACTR3 gene from Selected species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Actr31 , 5 ARP3 actin-related protein 3 homolog (yeast)5
    ARP3 actin-related protein 31
    93.46(n)1
    99.76(a)1
      1 (54.70 cM)5
    741171  NM_001205385.11  NP_001192314.11 
     1253929055 
    chicken
    (Gallus gallus)
    Aves ACTR31 ARP3 actin-related protein 3 homolog (yeast) 88.36(n)
    98.56(a)
      374197  NM_204307.1  NP_989638.1 
    lizard
    (Anolis carolinensis)
    Reptilia ACTR36
    ARP3 actin-related protein 3 homolog (yeast)
    99(a)
    1 ↔ 1
    1(80412051-80468137)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC047983.12   -- 81.86(n)    BC047983.1 
    zebrafish
    (Danio rerio)
    Actinopterygii actr31 ARP3 actin-related protein 3 homolog (yeast) 75.6(n)
    97.37(a)
      406250  NM_001003944.1  NP_001003944.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Arp66B3
    Arp31
    cell cycle dependent actin filament
    reorganization more3
    Actin-related protein 31
    80(a)3
    67.3(n)1
    80.62(a)1
      66B63
    388981  NM_079244.31  NP_523968.11 
    worm
    (Caenorhabditis elegans)
    Secernentea arx-11 arx-1 67.55(n)
    77.22(a)
      171857  NM_058665.4  NP_491066.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ARP31 ARP3 61.74(n)
    64.53(a)
      853528   NP_012599.3 
    rice
    (Oryza sativa)
    Liliopsida AK101163.12   -- 69.61(n)    AK101163.1 


    ENSEMBL Gene Tree for ACTR3 (if available)
    TreeFam Gene Tree for ACTR3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ACTR3 gene
    ACTR3C2  ACTR3B2  
    Selected SIMAP similar genes for ACTR3 using alignment to 6 protein entries:     ARP3_HUMAN (see all proteins) (see all similar genes):
    ACTR3B    ACTR3C    FKSG72    FKSG73    FKSG74    ACTL6B
    ACT    ACTB    ACTA2    ACTR1A    ACTR1B    ACTR2
    ACTBL2    PS1TP5BP1    ACTC1    POTEM    ACTG2    POTEI

    Find genes that share paralogs with ACTR3           About GenesLikeMe


    5 Pseudogenes.org Pseudogenes for ACTR3
    PGOHUM00000247736 PGOHUM00000260093 PGOHUM00000260292 PGOHUM00000236760 PGOHUM00000241828


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ACTR3 (see all 1358)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1880536621,2
    C--114650699(+) AATAAC/TAGAAC 3 -- int10--------
    rs1930611271,2
    --114650767(+) TTTTTA/TAAAAA 3 -- int10--------
    rs1467387541,2
    C--114650834(+) GGATC-/GTTTTT 3 -- int10--------
    rs1491540981,2
    C--114650866(+) GTTTT-/TTTG  
            
    TTTGT
    3 -- int10--------
    rs1390133521,2
    --114650890(+) GTTTTC/GAGATG 3 -- int10--------
    rs130238891,2
    C,F--114650965(+) tcccaG/Cgttca 3 -- int13Minor allele frequency- C:0.50NA WA 6
    rs1458031951,2
    C--114650975(+) AAGCTA/GTTCTC 3 -- int10--------
    rs76037641,2
    C,F,A--114651045(+) TTTCTC/ATTTTT 3 -- int1 trp37Minor allele frequency- A:0.24NA WA CSA EA 249
    rs1853442421,2
    --114651114(+) TCCACA/CCGCCT 3 -- int10--------
    rs1892811011,2
    --114651149(+) CAGGTC/GTGAGC 3 -- int10--------

    HapMap Linkage Disequilibrium report for ACTR3 (114647537 - 114720173 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ACTR3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv508860CNV Insertion20534489
    esv990446CNV Insertion20482838

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ACTR3
    DNA2.0 Custom Variant and Variant Library Synthesis for ACTR3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604222    OMIM disorders: --


    Find genes that share disorders with ACTR3           About GenesLikeMe

    3 Novoseek inferred disease relationships for ACTR3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    wiskott-aldrich syndrome 87 7 11694514 (1), 15800060 (1), 16246088 (1), 16682943 (1) (see all 6)
    carcinoma 11.5 5 18751399 (3), 14990971 (1)
    tumors 0 2 16912177 (1), 14990971 (1)

    Genetic Association Database (GAD): ACTR3

    Export disorders for ACTR3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ACTR3 gene, integrated from 10 sources (see all 139):
    (articles sorted by number of sources associating them with ACTR3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly. (PubMed id 9230079)1, 2, 3 Welch M.D.... Mitchison T.J. (J. Cell Biol. 1997)
    2. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (Nat. Biotechnol. 2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Reconstitution of human Arp2/3 complex reveals critical roles of individual subunits in complex structure and activity. (PubMed id 11741539)1, 2 Gournier H.... Welch M.D. (Mol. Cell 2001)
    5. Actin polymerization is induced by Arp2/3 protein complex at the surface of Listeria monocytogenes. (PubMed id 9000076)1, 2 Welch M.D.... Mitchison T.J. (Nature 1997)
    6. Interaction of cortactin and N-WASp with Arp2/3 complex. (PubMed id 12176354)1, 9 Weaver A.M....Cooper J.A. (Curr. Biol. 2002)
    7. The complex containing actin-related proteins Arp2 and Arp3 is required for the motility and integrity of yeast actin patches. (PubMed id 9210376)1, 9 Winter D....Li R. (Curr. Biol. 1997)
    8. ARP3beta, the gene encoding a new human actin-related protein, is alternatively spliced and predominantly expressed in brain neuronal cells. (PubMed id 10806390)1, 9 Jay P.... Berta P. (Eur. J. Biochem. 2000)
    9. Osmotic stress-induced remodeling of the cortical cytoskeleton. (PubMed id 12176742)1, 9 Di Ciano C....Kapus A. (Am. J. Physiol., Cell Physiol. 2002)
    10. Integration of multiple signals through cooperative regulation of the N-WASP-Arp2/3 complex. (PubMed id 11052943)1, 9 Prehoda K.E....Lim W.A. (Science 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10096 HGNC: 170 AceView: ACTR3 Ensembl:ENSG00000115091 euGenes: HUgn10096
    ECgene: ACTR3 H-InvDB: ACTR3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ACTR3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ACTR3 gene:
    Search GeneIP for patents involving ACTR3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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