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Aliases for ACTR3 Gene

Aliases for ACTR3 Gene

  • ARP3 Actin Related Protein 3 Homolog 2 3 5
  • Actin-Like Protein 3 3 4
  • ARP3 3 4
  • ARP3 (Actin-Related Protein 3, Yeast) Homolog 2
  • ARP3 Actin-Related Protein 3 Homolog (Yeast) 2
  • Actin-Related Protein 3 3

External Ids for ACTR3 Gene

Previous GeneCards Identifiers for ACTR3 Gene

  • GC02P111853
  • GC02P112568
  • GC02P114554
  • GC02P114742
  • GC02P114363
  • GC02P114647
  • GC02P106964

Summaries for ACTR3 Gene

Entrez Gene Summary for ACTR3 Gene

  • The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and motility through lamellipodial actin assembly and protrusion. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Mar 2013]

GeneCards Summary for ACTR3 Gene

ACTR3 (ARP3 Actin Related Protein 3 Homolog) is a Protein Coding gene. Diseases associated with ACTR3 include Wiskott-Aldrich Syndrome. Among its related pathways are Immune System and Immune response Role of DAP12 receptors in NK cells. GO annotations related to this gene include actin filament binding and structural constituent of cytoskeleton. An important paralog of this gene is ACTR3B.

UniProtKB/Swiss-Prot for ACTR3 Gene

  • Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament. Plays a role in ciliogenesis.

Gene Wiki entry for ACTR3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACTR3 Gene

Genomics for ACTR3 Gene

Regulatory Elements for ACTR3 Gene

Enhancers for ACTR3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F113824 0.3 FANTOM5 22.1 -65.6 -65566 0.2 GATA3 ACTR3 ENSG00000244063 LOC105373570
GH02F113923 0.8 ENCODE 21.4 +33.8 33768 1.0 TBL1XR1 BMI1 ETV6 CREM MTA2 BHLHE40 TRIM22 JUNB EP300 TBX21 ACTR3 ENSG00000244063 ENSG00000228857 RPL23AP7 ENSG00000279957 GC02P113964
GH02F113885 1.2 FANTOM5 ENCODE 20.6 +0.9 905 9.8 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 YY1 ACTR3 SLC35F5 ENSG00000227359 ENSG00000244063 LINC01191 RPL23AP7 DDX11L2 WASH2P CBWD2 LOC101060091
GH02F113854 0.9 Ensembl 20.1 -34.6 -34634 1.0 SRF L3MBTL2 MAX MYC MGA ACTR3 ENSG00000244063 ENSG00000228857 ENSG00000270019
GH02F113965 1 Ensembl ENCODE 19.8 +76.9 76925 1.7 ELF3 TBP MLX ARID4B ZSCAN9 RAD21 ZNF48 RARA ZNF143 CREM ACTR3 ENSG00000244063 LINC01191 GC02P113964
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ACTR3 on UCSC Golden Path with GeneCards custom track

Promoters for ACTR3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001545749 1066 4401 HDGF ARNT CREB3L1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 YY1

Genomic Location for ACTR3 Gene

Chromosome:
2
Start:
113,889,934 bp from pter
End:
113,962,596 bp from pter
Size:
72,663 bases
Orientation:
Plus strand

Genomic View for ACTR3 Gene

Genes around ACTR3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACTR3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACTR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACTR3 Gene

Proteins for ACTR3 Gene

  • Protein details for ACTR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61158-ARP3_HUMAN
    Recommended name:
    Actin-related protein 3
    Protein Accession:
    P61158
    Secondary Accessions:
    • P32391
    • Q53QM2

    Protein attributes for ACTR3 Gene

    Size:
    418 amino acids
    Molecular mass:
    47371 Da
    Quaternary structure:
    • Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC. Interacts with WHDC1. Interacts weakly with MEFV.

neXtProt entry for ACTR3 Gene

Post-translational modifications for ACTR3 Gene

  • Ubiquitination at Lys 38, Lys 69, Lys 75, Lys 99, Lys 191, Lys 251, Lys 254, Lys 265, Lys 317, Lys 348, and Lys 359
  • Modification sites at PhosphoSitePlus

Other Protein References for ACTR3 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ACTR3 (Arp3)

No data available for DME Specific Peptides for ACTR3 Gene

Domains & Families for ACTR3 Gene

Gene Families for ACTR3 Gene

Protein Domains for ACTR3 Gene

Graphical View of Domain Structure for InterPro Entry

P61158

UniProtKB/Swiss-Prot:

ARP3_HUMAN :
  • Belongs to the actin family. ARP3 subfamily.
Family:
  • Belongs to the actin family. ARP3 subfamily.
genes like me logo Genes that share domains with ACTR3: view

Function for ACTR3 Gene

Molecular function for ACTR3 Gene

UniProtKB/Swiss-Prot Function:
Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament. Plays a role in ciliogenesis.

Gene Ontology (GO) - Molecular Function for ACTR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005200 structural constituent of cytoskeleton IDA 11741539
GO:0005515 protein binding IPI 20195357
GO:0005524 ATP binding IEA --
GO:0051015 contributes_to actin filament binding IDA 11741539
genes like me logo Genes that share ontologies with ACTR3: view
genes like me logo Genes that share phenotypes with ACTR3: view

Animal Model Products

miRNA for ACTR3 Gene

miRTarBase miRNAs that target ACTR3

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ACTR3

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ACTR3 Gene

Localization for ACTR3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACTR3 Gene

Cytoplasm, cytoskeleton. Cell projection. Note=In pre-apoptotic cells, colocalizes with MEFV in large specks (pyroptosomes) (PubMed:19109554).

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ACTR3 Gene COMPARTMENTS Subcellular localization image for ACTR3 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
extracellular 5
nucleus 2
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ACTR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
GO:0005885 Arp2/3 protein complex IEA,TAS 9230079
GO:0005903 brush border IEA --
genes like me logo Genes that share ontologies with ACTR3: view

Pathways & Interactions for ACTR3 Gene

genes like me logo Genes that share pathways with ACTR3: view

Gene Ontology (GO) - Biological Process for ACTR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006928 movement of cell or subcellular component TAS 9230079
GO:0007015 actin filament organization IEA --
GO:0007163 establishment or maintenance of cell polarity IEA --
GO:0008356 asymmetric cell division IEA --
GO:0016344 meiotic chromosome movement towards spindle pole IEA --
genes like me logo Genes that share ontologies with ACTR3: view

No data available for SIGNOR curated interactions for ACTR3 Gene

Drugs & Compounds for ACTR3 Gene

(3) Drugs for ACTR3 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
(2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one Experimental Pharma Target 0
N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide Experimental Pharma Target 0

(1) Additional Compounds for ACTR3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ACTR3: view

Transcripts for ACTR3 Gene

Unigene Clusters for ACTR3 Gene

ARP3 actin-related protein 3 homolog (yeast):
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ACTR3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ACTR3 Gene

No ASD Table

Relevant External Links for ACTR3 Gene

GeneLoc Exon Structure for
ACTR3
ECgene alternative splicing isoforms for
ACTR3

Expression for ACTR3 Gene

mRNA expression in normal human tissues for ACTR3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ACTR3 Gene

This gene is overexpressed in Whole Blood (x4.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ACTR3 Gene



Protein tissue co-expression partners for ACTR3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ACTR3 Gene:

ACTR3

SOURCE GeneReport for Unigene cluster for ACTR3 Gene:

Hs.433512
genes like me logo Genes that share expression patterns with ACTR3: view

Primer Products

No data available for Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ACTR3 Gene

Orthologs for ACTR3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ACTR3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ACTR3 34 35
  • 99.68 (n)
dog
(Canis familiaris)
Mammalia ARP3 35
  • 97 (a)
OneToOne
ACTR3B 34
  • 96.73 (n)
cow
(Bos Taurus)
Mammalia ACTR3 34 35
  • 96.33 (n)
mouse
(Mus musculus)
Mammalia Actr3 34 16 35
  • 93.46 (n)
rat
(Rattus norvegicus)
Mammalia Actr3 34
  • 93.3 (n)
oppossum
(Monodelphis domestica)
Mammalia ACTR3 35
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves ACTR3 34 35
  • 88.36 (n)
lizard
(Anolis carolinensis)
Reptilia ACTR3 35
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia actr3 34
  • 79.11 (n)
zebrafish
(Danio rerio)
Actinopterygii ACTR3 (1 of 2) 35
  • 97 (a)
OneToMany
ACTR3 (2 of 2) 35
  • 97 (a)
OneToMany
actr3 34
  • 75.6 (n)
fruit fly
(Drosophila melanogaster)
Insecta Arp66B 36 35
  • 80 (a)
Arp3 34
  • 67.3 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005110 34
  • 68.9 (n)
worm
(Caenorhabditis elegans)
Secernentea arx-1 34 35
  • 67.55 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARP3 34 35
  • 61.74 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B13904g 34
  • 59.93 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR419C 34
  • 59.75 (n)
barley
(Hordeum vulgare)
Liliopsida Hv.5713 34
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes arp3 34
  • 60.58 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU01756 34
  • 57.7 (n)
Species where no ortholog for ACTR3 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ACTR3 Gene

ENSEMBL:
Gene Tree for ACTR3 (if available)
TreeFam:
Gene Tree for ACTR3 (if available)

Paralogs for ACTR3 Gene

Paralogs for ACTR3 Gene

genes like me logo Genes that share paralogs with ACTR3: view

Variants for ACTR3 Gene

Sequence variations from dbSNP and Humsavar for ACTR3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10165272 -- 113,918,272(+) tgtct(A/G)tgcta intron-variant
rs10167298 -- 113,958,788(+) TAGCA(A/G)TATCA nc-transcript-variant, utr-variant-3-prime
rs10168066 -- 113,901,047(+) gggca(C/T)ggtgg intron-variant
rs10168522 -- 113,888,996(+) gccca(G/T)caatc intron-variant, upstream-variant-2KB
rs10173854 -- 113,899,289(+) AATGA(A/G)TAATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ACTR3 Gene

Variant ID Type Subtype PubMed ID
esv3334973 CNV insertion 20981092
esv990446 CNV insertion 20482838
nsv1127757 CNV deletion 24896259
nsv479438 CNV novel sequence insertion 20440878
nsv508860 CNV insertion 20534489

Variation tolerance for ACTR3 Gene

Residual Variation Intolerance Score: 29.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.08; 21.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ACTR3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ACTR3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACTR3 Gene

Disorders for ACTR3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ACTR3 Gene - From: Novoseek and GeneCards

Disorder Aliases PubMed IDs
wiskott-aldrich syndrome
  • wiskott syndrome
- elite association - COSMIC cancer census association via MalaCards
Search ACTR3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ACTR3

Genetic Association Database (GAD)
ACTR3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ACTR3
genes like me logo Genes that share disorders with ACTR3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ACTR3 Gene

Publications for ACTR3 Gene

  1. The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly. (PMID: 9230079) Welch M.D. … Mitchison T.J. (J. Cell Biol. 1997) 2 3 4 64
  2. Functional genomic screen for modulators of ciliogenesis and cilium length. (PMID: 20393563) Kim J. … Gleeson J.G. (Nature 2010) 3 4 64
  3. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PMID: 15592455) Rush J. … Comb M.J. (Nat. Biotechnol. 2005) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Interaction of cortactin and N-WASp with Arp2/3 complex. (PMID: 12176354) Weaver A.M. … Cooper J.A. (Curr. Biol. 2002) 3 22 64

Products for ACTR3 Gene

Sources for ACTR3 Gene

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