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ACTR3 Gene

protein-coding GIFtS: 54

GC02P114363

ARP3 actin-related protein 3 homolog (yeast)
(Previous names: ARP3 (actin-related protein 3, yeast) homolog )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
ARP3 ^¹, ², ³

Descriptions
ARP3 (actin-related protein 3, yeast) homolog ^¹
ARP3 actin-related protein 3 homolog ^²
ARP3 actin-related protein 3 homolog (yeast) ^²
Actin-like protein 3 ^³

External Ids
HGNC: 170¹
Entrez Gene: 10096²
UniProtKB: P61158³
Ensembl: ENSG00000115091⁷

Search outside databases for aliases for ACTR3 gene

Previous GC identifers: GC02P111853 GC02P112568 GC02P114554 GC02P114742

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ACTR3:

The specific function of this gene has not yet been determined; however, the protein it encodes is

known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface

and is essential to cell shape and motility through lamellipodial actin assembly and protrusion.

[provided by RefSeq]

UniProtKB/Swiss-Prot: ARP3_HUMAN, P61158

Function: Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation

of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates

the formation of branched actin networks. Seems to contact the pointed end of the daughter actin

filament

Gene Wiki entry for ACTR3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ACTR3 gene

Entrez Gene cytogenetic band: 2q14.1 Ensembl cytogenetic band: 2q14.1 HGNC cytogenetic band: 2q14.1

ACTR3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P114363: (about GC identifiers)

Start:	114,364,007 bp from pter
End:	114,432,637 bp from pter
Size:	68,631 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000002.10 NT_022135.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ARP3_HUMAN, P61158 (See protein sequence)

Recommended Name: Actin-related protein 3

Size: 418 amino acids; 47371 Da

Subunit: Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC,

ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC. Interacts with WHDC1

Subcellular location: Cytoplasm, cytoskeleton. Cell projection

Secondary accessions: P32391

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_005712.1

ENSEMBL proteins:

ENSP00000263238

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Arp3)
	Human Recombinant Proteins from Abnova (ACTR3)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--
GO:0005885	Arp2/3 protein complex	TAS	9230079
GO:0030027	lamellipodium	IEA	--

About this table

Antibodies for ACTR3:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of ACTR3
	Sigma-Aldrich Antibody Arrays and Antibodies for ACTR3
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for ACTR3 (ARP3)
	Antibodies from Abcam (Arp3), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ACTR3)
	Novus Biologicals Antibody for ACTR3

Assays for ACTR3:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P61158

ProtoNet protein and cluster: P61158

UniProtKB/Swiss-Prot: ARP3_HUMAN, P61158

Similarity: Belongs to the actin family. ARP3 subfamily

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ACTR3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ACTR3)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005721

Applied Biosystems Silencer® siRNAs for ACTR3

Sigma-Aldrich siRNA for ACTR3

Sigma-Aldrich shRNA Panels and shRNA for ACTR3

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ACTR3
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_005721
Myc/DDK tagged cDNA clone in CMV expression vector: NM_005721
untagged cDNA clone in CMV expression vector: NM_005721

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_005721

UniProtKB/Swiss-Prot: ARP3_HUMAN, P61158

Function: Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation

of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates

the formation of branched actin networks. Seems to contact the pointed end of the daughter actin

filament

2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Actr3):

embryogenesis

lethality-prenatal/perinatal

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0003779	actin binding	IEA	--
GO:0005515	protein binding	IPI	17353931
GO:0005524	ATP binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/9 Sigma-Aldrich "Your Favorite Gene" Pathways for ACTR3 (Your Favorite Gene powered by Ingenuity) (see all 9 )

Ephrin Receptor Signaling
fMLP Signaling in Neutrophils
Clathrin-mediated Endocytosis
Actin Cytoskeleton Signaling
Regulation of Actin-based Motility by Rho

GeneDecks ACTR3 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for ACTR3

5/15 Interacting proteins for ACTR3 (P61158¹ ENSP00000263238³) via UniProtKB, MINT, and/or STRING (see all 15 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
EIF1B	O60739¹	EBI-351428, EBI-1043343
ARPC3	ENSP00000228825³	STRING (score=.998)
ARPC2	ENSP00000327137³	STRING (score=.997)
BRPF1	ENSP00000373340³	STRING (score=.997)
ARPC1B	ENSP00000252725³	STRING (score=.993)

About this table

2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006928	cell motion	TAS	9230079
GO:0030833	regulation of actin filament polymerization	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ACTR3
2 Novoseek chemical compound relationships for ACTR3 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	25.87	1	16912177 (1)
phosphatidylinositol	12.59	2	11694514 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ACTR3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ACTR3)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005721

Sigma-Aldrich siRNA for ACTR3

Sigma-Aldrich shRNA Panels and shRNA for ACTR3

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_005721

REFSEQ mRNAs for ACTR3 gene:

NM_005721.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_005721

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005721
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_005721
                                 untagged cDNA clone in CMV expression vector: NM_005721

Additional cDNA sequence:

AB209353.1 AF006083.1 AF127773.1 AK300030.1 AK300224.1 AK302152.1 AK302359.1 AK303988.1

AK312659.1 AK316213.1 AK316396.1 BC044590.1 CR620086.1

24 DOTS entries:

DT.418993 DT.95151555 DT.95082634 DT.40106744 DT.100825760 DT.101976946 DT.120943942 DT.120943924

DT.95264748 DT.120943855 DT.120943892 DT.75161379 DT.100825759 DT.100825768 DT.120943901 DT.121462832

DT.40190993 DT.97831938 DT.99950190 DT.95310888 DT.100825755 DT.120943931 DT.92456021 DT.95254566

24/669 AceView cDNA sequences (see all 669 ):

AA252183 AL704423 BQ223258 BQ058832 BM710667 BU520973 BP342071 AA333972

AI472311 BM467835 BM981068 BM834447 CB136826 AI753500 BE889991 BM803775

CB850944 CR598724 AI828414 CR601322 BC044590 CB122480 AW662090 D57546

highest scoring ESTs for ACTR3:

AF006083 AA010466 AA035543 AA040531 AA040532 AA062941 AA157475 AA164562 AA180884 AA180969

Unigene Cluster for ACTR3:

ARP3 actin-related protein 3 homolog (yeast)

Hs.433512 [show with all ESTs]

Unigene Representative Sequence: BC044590

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000263238

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ACTR3 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ACTR3

¹ / ² / ³

7 probe-sets matching ACTR3 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
35271_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	AF006083	1.00	0.80	0.91	1
213101_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	Z78330	0.40	0.75	0.60	1
213102_at²^{, 3}	U133-A	1	1.00	1.00	--	--	Z78330	0.40	0.75	0.60	1
200996_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_005721	0.60	0.83	0.73	1
213101_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
213102_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
200996_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AGACTTGGCA

SOURCE GeneReport for Unigene cluster: Hs.433512
Expression variation in blood from EXPOLDB for ACTR3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ACTR3 gene from 5/15 species (see all 15 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ACTR3¹	--	ARP3 actin-related protein 3 homolog (yeast)	96.23(n) 99.51(a)	403702 XM_848216.1 XP_853309.1
chimpanzee (Pan troglodytes)	ACTR3¹	--	ARP3 actin-related protein 3 homolog (yeast)	99.68(n) 100(a)	459563 XM_001154210.1 XP_001154210.1
cow (Bos taurus)	ACTR3¹	--	ARP3 actin-related protein 3 homolog (yeast)	96.33(n) 100(a)	281597 NM_174226.2 NP_776651.1
rat (Rattus norvegicus)	Actr3¹	--	ARP3 actin-related protein 3 homolog (yeast)	93.3(n) 99.76(a)	81732 NM_031068.1 NP_112330.1
mouse (Mus musculus)	Actr3^{1, 5}	1⁵	ARP3 actin-related protein 3 homolog (yeast)^{1, 5}	93.46(n)¹ 99.76(a)¹	74117¹ NM_023735.1¹ NP_076224.1¹ AA118546⁵ AF307855⁵ (see all 33)

About this table Species with no ortholog for ACTR3

ENSEMBL Gene Tree for ACTR3

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ACTR3 gene

ACTL8² ENSG00000181786² ARP11² ACTL7A² ACTL7B² ACTR3B²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/483 NCBI SNPs in ACTR3 are shown (see all 483 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 159)

AB	SNP ID	Valid	Chr 2 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
--	rs6642^1,2	A,C,F,H	114432003(+)	`CACTCG/ATGGGA`	1	--	ut3¹ ese³		9	MN EU EA WA NA	932
	rs10167298^1,2	A,C,F,H	114432835(+)	`TAGCAG/ATATCA`	1	--	ng3¹		7	NA EU EA WA	550
	rs809810^1,2	C,H	114408371(+)	`TAGGAG/AAACGG`	1	K/E	mis¹		5	MN EU EA WA	600
--	rs407371^1,2	H	114416315(+)	`ACAGTA/GTACTG`	1	Y/C	mis¹ ese³		4	EU EA WA	400
	rs34493552^1,2	C,F	114425889(+)	`AGATTG/AAAGGT`	1	L/L	syn¹		1	NA	76
	rs1522915^1,2	A,C,F,H,O	114373821(-)	`attaaA/Gtatca`	1	--	int¹		7	EU EA WA NA	560
	rs1403402^1,2	A,C,F,H,O	114371218(-)	`AATGTC/TGTGTT`	1	--	int¹		11	EU EA WA NA	960
	rs1394165^1,2	A,C,F,H,O	114375680(-)	`CTCTTT/CCCAAA`	1	--	int¹		7	MN EU EA WA NA	784
	rs1504042^1,2	A,C,F,H,O	114370997(-)	`AACTTC/TTGCTC`	1	--	int¹		12	EA NA EU WA	2398
	rs996515^1,2	A,C,F,H,O	114365370(-)	`AACACA/CCTCCT`	1	--	int¹		14	NA EA EU WA	2360

About this table

HapMap Linkage Disequilibrium images for ACTR3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 604222

3 Novoseek disease relationships for ACTR3 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
wiskott-aldrich syndrome	87.71	7	11694514 (1), 15800060 (1), 16246088 (1), 16682943 (1) (see all 6)
carcinoma	13.41	5	18751399 (3), 14990971 (1)
tumors	0.00	2	16912177 (1), 14990971 (1)

About this table

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/95 PubMed articles for ACTR3 gene (see all 95 ):

The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly. (PubMed id 9230079)^{2, 3, 4} Welch M.D....Mitchison T.J. (1997)
Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)^{3, 4} Rush J.... Comb M.J. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Reconstitution of human Arp2/3 complex reveals critical roles of individual subunits in complex structure and activity. (PubMed id 11741539)^{3, 4} Gournier H.... Welch M.D. (2001)
Actin polymerization is induced by Arp2/3 protein complex at the surface of Listeria monocytogenes. (PubMed id 9000076)^{3, 4} Welch M.D.... Mitchison T.J. (1997)
Interaction of cortactin and N-WASp with Arp2/3 complex. (PubMed id 12176354)^{1, 3} Weaver A.M....Cooper J.A. (2002)
The complex containing actin-related proteins Arp2 and Arp3 is required for the motility and integrity of yeast actin patches. (PubMed id 9210376)^{1, 3} Winter D....Li R. (1997)
ARP3beta, the gene encoding a new human actin-related protein, is alternatively spliced and predominantly expressed in brain neuronal cells. (PubMed id 10806390)^{1, 3} Jay P....Berta P. (2000)
Osmotic stress-induced remodeling of the cortical cytoskeleton. (PubMed id 12176742)^{1, 3} Di Ciano C....Kapus A. (2002)
Integration of multiple signals through cooperative regulation of the N-WASP-Arp2/3 complex. (PubMed id 11052943)^{1, 3} Prehoda K.E....Lim W.A. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 10096	HGNC: 170	AceView: ACTR3	Ensembl:ENSG00000115091	euGenes: HUgn10096
ECgene: ACTR3	H-InvDB: ACTR3

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for ACTR3
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ACTR3:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ACTR3-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ACTR3		Antibodies for ACTR3
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ACTR3		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (ACTR3)
	Antibodies (ACTR3)
	Chimera RNAi (ACTR3)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for ACTR3 (ARP3)

	Recombinant Proteins (Arp3)
	Antibodies (Arp3)

Search OriGene for ACTR3

Search Tocris compounds for ACTR3

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for ACTR3

GeneCards Homepage - Last full update: 1 Jul 2009 Incremental update: 13 Oct 2009

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ACTR3 Gene

protein-coding GIFtS: 54

Aliases &
Descriptions
for ACTR3

Summaries
for ACTR3

Genomic Location
for ACTR3

Proteins
for ACTR3

Protein Domains/
Families
for ACTR3

Gene Function
for ACTR3

Pathways & Interactions
for ACTR3

Drugs & Compounds
for ACTR3

Transcripts
for ACTR3

Expression
for ACTR3

Orthologs
for ACTR3

Paralogs
for ACTR3

SNPs/Variants
for ACTR3

Disorders & Mutations
for ACTR3

Medical News
for ACTR3

Publications
for ACTR3

Search for ACTR3

Genome Databases showing ACTR3

Other Databases showing ACTR3

Specialized Databases showing ACTR3

Licensable Technologies
for ACTR3

Services
for ACTR3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ACTR3 Gene

protein-coding GIFtS: 54

Aliases & Descriptionsfor ACTR3

Summariesfor ACTR3

Genomic Locationfor ACTR3

Proteinsfor ACTR3

Protein Domains/Familiesfor ACTR3

Gene Functionfor ACTR3

Pathways & Interactionsfor ACTR3

Drugs & Compoundsfor ACTR3

Transcriptsfor ACTR3

Expression for ACTR3

Orthologsfor ACTR3

Paralogsfor ACTR3

SNPs/Variantsfor ACTR3

Disorders & Mutationsfor ACTR3

Medical Newsfor ACTR3

Publicationsfor ACTR3

Search for ACTR3

Genome Databases showing ACTR3

Other Databases showing ACTR3

Specialized Databases showing ACTR3

Licensable Technologiesfor ACTR3

Servicesfor ACTR3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ACTR3

Summaries
for ACTR3

Genomic Location
for ACTR3

Proteins
for ACTR3

Protein Domains/
Families
for ACTR3

Gene Function
for ACTR3

Pathways & Interactions
for ACTR3

Drugs & Compounds
for ACTR3

Transcripts
for ACTR3

Expression
for ACTR3

Orthologs
for ACTR3

Paralogs
for ACTR3

SNPs/Variants
for ACTR3

Disorders & Mutations
for ACTR3

Medical News
for ACTR3

Publications
for ACTR3

Licensable Technologies
for ACTR3

Services
for ACTR3