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ACTR2 Gene

protein-coding   GIFtS: 61
GCID: GC02P065454

ARP2 Actin-Related Protein 2 Homolog (Yeast)

(Previous names: ARP2 (actin-related protein 2, yeast) homolog)
  See ACTR2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ARP2 Actin-Related Protein 2 Homolog (Yeast)1 2
Actin-Like Protein 22 3
ARP22 3
ARP2 (Actin-Related Protein 2, Yeast) Homolog1
Actin-Related Protein 22

External Ids:    HGNC: 1691   Entrez Gene: 100972   Ensembl: ENSG000001380717   OMIM: 6042215   UniProtKB: P611603   

Export aliases for ACTR2 gene to outside databases

Previous GC identifers: GC02P065588 GC02P065412 GC02P065429 GC02P065366 GC02P065308 GC02P065189


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ACTR2 Gene:
The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a
major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell
shape and motility through lamellipodial actin assembly and protrusion. Two transcript variants encoding
different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for ACTR2 Gene:
ACTR2 (ARP2 actin-related protein 2 homolog (yeast)) is a protein-coding gene. Diseases associated with ACTR2 include wiskott-aldrich syndrome. GO annotations related to this gene include actin binding. An important paralog of this gene is ACTL8.

UniProtKB/Swiss-Prot: ARP2_HUMAN, P61160
Function: Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin
polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of
branched actin networks. Seems to contact the pointed end of the daughter actin filament

Gene Wiki entry for ACTR2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the ACTR2 gene promoter:
         c-Fos   AP-1   p53   JunB   Fra-1   FosB   YY1   JunD   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidACTR2 promoter sequence
   Search Chromatin IP Primers for ACTR2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ACTR2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p14   Ensembl cytogenetic band:  2p14   HGNC cytogenetic band: 2p14

ACTR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ACTR2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P065454:  view genomic region     (about GC identifiers)

Start:
65,454,829 bp from pter      End:
65,498,387 bp from pter
Size:
43,559 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ARP2_HUMAN, P61160 (See protein sequence)
Recommended Name: Actin-related protein 2  
Size: 394 amino acids; 44761 Da
Subunit: Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC,
ARPC4/p20-ARC and ARPC5/p16-ARC
Secondary accessions: B2RCP5 D6W5F4 E9PF41 O15142 Q96C82
Alternative splicing: 2 isoforms:  P61160-1   P61160-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ACTR2: NX_P61160

Explore proteomics data for ACTR2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys7, Lys19, Lys46, Lys53, Lys86, Lys97, Lys106, Lys118, Lys195, Lys219,
                                 Lys299, Lys322, Lys336, Lys366, Lys368, Lys381, Lys388
  • Modification sites at PhosphoSitePlus

  • See ACTR2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001005386.1  NP_005713.1  

    ENSEMBL proteins: 
     ENSP00000260641   ENSP00000367220   ENSP00000437383  
    Reactome Protein details: P61160

    ACTR2 Human Recombinant Protein Products:

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    Novus Biologicals ACTR2 Protein
    Novus Biologicals ACTR2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ACTR2

     
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    ACTR2 Antibody Products:

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    Search eBioscience for ELISAs for ACTR2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR020902 Actin/actin-like_CS
     IPR004000 Actin-related
     IPR027306 Arp2

    Graphical View of Domain Structure for InterPro Entry P61160

    ProtoNet protein and cluster: P61160

    UniProtKB/Swiss-Prot: ARP2_HUMAN, P61160
    Similarity: Belongs to the actin family. ARP2 subfamily


    Find genes that share domains with ACTR2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ARP2_HUMAN, P61160
    Function: Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin
    polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of
    branched actin networks. Seems to contact the pointed end of the daughter actin filament

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0005524ATP binding IEA--
         
    Find genes that share ontologies with ACTR2           About GenesLikeMe


    Phenotypes:
         5 GenomeRNAi human phenotypes for ACTR2:
     Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella-containin 
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ACTR2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ACTR2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ACTR2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ACTR2

    miRNA
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    miRTarBase miRNAs that target ACTR2:
    hsa-mir-192-5p (MIRT026515), hsa-mir-132-3p (MIRT021852), hsa-mir-21-5p (MIRT030897), hsa-mir-93-5p (MIRT028015), hsa-mir-155-5p (MIRT020780), hsa-mir-215-5p (MIRT024581)

    Block miRNA regulation of human, mouse, rat ACTR2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ACTR2 (see all 36):
    hsa-miR-607 hsa-miR-4254 hsa-miR-3146 hsa-miR-24-1* hsa-miR-15a hsa-miR-503 hsa-miR-890 hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidACTR2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ACTR2

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 4): ACTR2 (NM_001100164)
    Sino Biological Human cDNA Clone for ACTR2
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACTR2

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    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-12088) for ACTR2 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ARP2_HUMAN, P61160: Cytoplasm, cytoskeleton. Cell projection
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol4
    extracellular1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0005885Arp2/3 protein complex TAS9230079
    GO:0005938cell cortex ----
    GO:0015629actin cytoskeleton TAS9230079
    GO:0030478actin cap IEA--

    Find genes that share ontologies with ACTR2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ACTR2 About   (see all 26)  
    See pathways by source

    SuperPathContained pathways About
    1Development Slit Robo signaling
    Development Slit Robo signaling0.92
    Neurophysiological process Receptor mediated axon growth repulsion0.41
    Cytoskeleton remodeling Slit Robo signaling0.92
    2Immune response CCR3 signaling in eosinophils
    Inhibitory action of Lipoxins on neutrophil migration0.51
    Immune response CCR3 signaling in eosinophils0.51
    3Actin Nucleation by ARP-WASP Complex
    Actin Nucleation and Branching0.66
    CDC42 Pathway0.41
    Actin Nucleation by ARP-WASP Complex0.66
    RhoA Pathway0.35
    4Cell adhesion Integrin mediated cell adhesion and migration
    Cell adhesion Integrin mediated cell adhesion and migration0.49
    Cytoskeleton remodeling Integrin outside in signaling0.37
    Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases0.49
    Cytoskeleton remodeling Fibronectin binding integrins in cell motility0.32
    5Fcgamma receptor (FCGR) dependent phagocytosis
    Regulation of actin dynamics for phagocytic cup formation0.77
    Fcgamma receptor (FCGR) dependent phagocytosis0.77


    Find genes that share SuperPaths with ACTR2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ACTR2 (see all 20)
        RhoA Pathway
    Actin-Based Motility by Rho Family GTPases
    Remodeling of Adherens Junctions
    Guidance Cues and Growth Cone Motility
    Signaling by Slit

    1 Cell Signaling Technology (CST) Pathway for ACTR2
        Cytoskeletal Signaling

    Selected GeneGo (Thomson Reuters) Pathways for ACTR2 (see all 14)
        Cytoskeleton remodeling CDC42 in cellular processes
    Immune response CD16 signaling in NK cells
    Cytoskeleton remodeling Fibronectin-binding integrins in cell motility
    Neurophysiological process Receptor-mediated axon growth repulsion
    Cytoskeleton remodeling Integrin outside-in signaling

    4 BioSystems Pathways for ACTR2
        B Cell Receptor Signaling Pathway
    CDC42 signaling events
    ErbB1 downstream signaling
    RAC1 signaling pathway


    1 Reactome Pathway for ACTR2
        Regulation of actin dynamics for phagocytic cup formation


        Pathway & Disease-focused RT2 Profiler PCR Arrays including ACTR2: 
              Cytoskeleton Regulators in human mouse rat
              EGF / PDGF Signaling Pathway in human mouse rat
              Cell Motility in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ACTR2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ACTR2 (P611602, 3 ENSP000003672204) via UniProtKB, MINT, STRING, and/or I2D (see all 1009)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PSMC6P623332, 3, ENSP000004018024MINT-7945693 MINT-7947479 I2D: score=3 STRING: ENSP00000401802
    ACTBP607092, 3, ENSP000003499604MINT-7945693 MINT-7947479 I2D: score=2 STRING: ENSP00000349960
    CCT3P493682, 3, ENSP000003572444MINT-7945693 MINT-7947479 I2D: score=2 STRING: ENSP00000357244
    PSMC3P179802, 3, ENSP000002988524MINT-7945693 MINT-7947479 I2D: score=2 STRING: ENSP00000298852
    PSMC4P436862, 3MINT-7945693 MINT-7947479 I2D: score=4 
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    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006928cellular component movement TAS9230079
    GO:0007163establishment or maintenance of cell polarity IEA--
    GO:0008356asymmetric cell division IEA--
    GO:0016482cytoplasmic transport IEA--
    GO:0030036actin cytoskeleton organization IEA--

    Find genes that share ontologies with ACTR2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ACTR2 (ARP2)

    2 DrugBank Compounds for ACTR2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one-- --target--10592235
    N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide-- --target--10592235

    1 Novoseek inferred chemical compound relationship for ACTR2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    atp 4.2 5 11752435 (3), 17251352 (1)



    Find genes that share compounds with ACTR2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ACTR2 gene (2 alternative transcripts): 
    NM_001005386.2  NM_005722.3  

    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000260641(uc002sdp.3 uc002sdq.3 uc010yqg.2) ENST00000476840
    ENST00000471552 ENST00000377982 ENST00000542850(uc010yqf.1)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ACTR2 (see all 36):
    hsa-miR-607 hsa-miR-4254 hsa-miR-3146 hsa-miR-24-1* hsa-miR-15a hsa-miR-503 hsa-miR-890 hsa-miR-424
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    Selected AceView cDNA sequences (see all 845):

    BM993143 BQ691084 AL538895 BM452012 BU186139 BU429333 W69469 AA047331 
    BX957065 AA480334 F03430 AA663066 BX646626 AU131915 AA042888 BP346190 
    AI023074 AL710875 BU625727 BQ019871 BQ424114 BU616817 BQ021352 Z40245 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ACTR2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATACTTCA
    ACTR2 Expression
    About this image


    ACTR2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 17) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Blood (Hematopoietic System)
             Plasmacytoid Dendritic cells Peripheral Blood
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
     
     Uterus (Reproductive System)
    ACTR2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ACTR2 Protein Expression
        Pathway & Disease-focused RT2 Profiler PCR Arrays including ACTR2: 
              Cytoskeleton Regulators in human mouse rat
              EGF / PDGF Signaling Pathway in human mouse rat
              Cell Motility in human mouse rat

    Primer
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACTR2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ACTR2 gene from Selected species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Actr21 , 5 ARP2 actin-related protein 2 homolog (yeast)5
    ARP2 actin-related protein 21
    92.22(n)1
    100(a)1
      11 (12.88 cM)5
    667131  NM_146243.21  NP_666355.11 
     200623045 
    chicken
    (Gallus gallus)
    Aves ACTR21 ARP2 actin-related protein 2 homolog (yeast) 85.45(n)
    98.98(a)
      396147  NM_205224.1  NP_990555.1 
    lizard
    (Anolis carolinensis)
    Reptilia ACTR26
    ARP2 actin-related protein 2 homolog (yeast)
    92(a)
    1 ↔ 1
    1(124520012-124556947)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC043992.12   -- 84.75(n)    BC043992.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC055220.12   -- 78.26(n)    BC055220.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Arp14D3
    Arp21
    cytoskeleton organization and
    biogenesis structural more3
    Actin-related protein 21
    81(a)3
    67.17(n)1
    81.47(a)1
      14E13
    326231  NM_001272692.11  NP_001259621.11 
    worm
    (Caenorhabditis elegans)
    Secernentea arx-21 arx-2 66.84(n)
    76.47(a)
      179440  NM_073256.6  NP_505657.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ARP2(YDL029W)4
    ARP21
    Essential component of the Arp2/3 complex, which is more4
    ARP21
    63.01(n)1
    67.89(a)1
      4(399340-400638)4
    8515321, 4  NP_010255.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ARP21 ARP2 60.07(n)
    62.76(a)
      822317  NM_113614.2  NP_189336.1 
    rice
    (Oryza sativa)
    Liliopsida Os08g03693001 Os08g0369300 60.75(n)
    60.85(a)
      4345402  NM_001068190.2  NP_001061655.2 


    ENSEMBL Gene Tree for ACTR2 (if available)
    TreeFam Gene Tree for ACTR2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ACTR2 gene
    ACTL82  ACTL7A2  ACTL7B2  ACTL92  ACTL102  
    Selected SIMAP similar genes for ACTR2 using alignment to 3 protein entries:     ARP2_HUMAN (see all proteins) (see all similar genes):
    ACTB    ACT    ACTG1    ACTA2    PS1TP5BP1    ACTBL2
    ACTC1    POTEM    POTEKP    POTEI    POTEJ    ACTR1B
    ACTG2    POTEE    POTEF    ACTR1A    ACTR6    ACTL6B

    Find genes that share paralogs with ACTR2           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for ACTR2
    PGOHUM00000256847 PGOHUM00000246543


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ACTR2 (see all 982)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs586849181,2
    C--65214929(+) TCTTA-/AAAGA 
            
    GAACA
    2 -- int12Minor allele frequency- AAAGA:0.25NA 4
    rs1866361331,2
    --65452876(+) TTATAA/GTAAGT 2 -- us2k10--------
    rs106570621,2
    C--65453001(+) TTTTT-/TTTTTT
    /TTTTTTT
    GAGAC
    4 -- us2k1 cds1 trp31NA 2
    rs1915338891,2
    --65453004(+) TTTGAA/GACAGA 2 -- us2k10--------
    rs1392555651,2
    --65453088(+) GATTCA/TCCTGC 2 -- us2k10--------
    rs1829113381,2
    --65453123(+) TACAGA/GCGCGT 2 -- us2k10--------
    rs1852208761,2
    --65453124(+) ACAGGC/GGCGTG 2 -- us2k10--------
    rs1896936711,2
    --65453197(+) CTTGTC/TTTGAA 2 -- us2k10--------
    rs134281091,2
    C--65453294(+) TTCTTC/TAAAAA 2 -- us2k1 trp30--------
    rs134148831,2
    C,F--65453444(+) GATACG/AGACTC 2 -- us2k17Minor allele frequency- A:0.38NA WA CSA 247

    HapMap Linkage Disequilibrium report for ACTR2 (65454829 - 65498387 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ACTR2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv527241CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ACTR2
    DNA2.0 Custom Variant and Variant Library Synthesis for ACTR2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604221    OMIM disorders: --

    1 disease for ACTR2:    
    About MalaCards
    wiskott-aldrich syndrome

    1 disease from the University of Copenhagen DISEASES database for ACTR2:
    Wiskott-Aldrich syndrome

    Find genes that share disorders with ACTR2           About GenesLikeMe

    4 Novoseek inferred disease relationships for ACTR2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    wiskott-aldrich syndrome 79 4 16638851 (2), 11598103 (1), 17277766 (1)
    metastasis 0.743 8 17459058 (4), 16638851 (2)
    tumors 0 4 14990971 (3), 16638851 (1)
    cancer 0 6 17459058 (3), 16638851 (3)

    Human Genome Epidemiology (HuGE) Navigator: ACTR2 (1 document)

    Export disorders for ACTR2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ACTR2 gene, integrated from 10 sources (see all 120):
    (articles sorted by number of sources associating them with ACTR2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly. (PubMed id 9230079)1, 2, 3 Welch M.D.... Mitchison T.J. (J. Cell Biol. 1997)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Reconstitution of human Arp2/3 complex reveals critical roles of individual subunits in complex structure and activity. (PubMed id 11741539)1, 2 Gournier H.... Welch M.D. (Mol. Cell 2001)
    4. Actin polymerization is induced by Arp2/3 protein complex at the surface of Listeria monocytogenes. (PubMed id 9000076)1, 2 Welch M.D.... Mitchison T.J. (Nature 1997)
    5. Coexpression of actin-related protein 2 and Wiskott-Aldrich syndrome family verproline-homologous protein 2 in adenocarcinoma of the lung. (PubMed id 16638851)1, 9 Semba S....Mukai K. (Clin. Cancer Res. 2006)
    6. Correlation between liver metastasis of the colocalization of actin-related protein 2 and 3 complex and WAVE2 in colorectal carcinoma. (PubMed id 17459058)1, 9 Iwaya K....Mukai K. (Cancer Sci. 2007)
    7. Actin-related protein (Arp2) inserts into artificial lipid membranes. (PubMed id 12468383)1, 9 Goldmann W.H. and Isenberg G. (Cell Biol. Int. 2002)
    8. Interaction of cortactin and N-WASp with Arp2/3 complex. (PubMed id 12176354)1, 9 Weaver A.M....Cooper J.A. (Curr. Biol. 2002)
    9. Sequential interaction of actin-related proteins 2 and 3 (Arp2/3) complex with neural Wiscott-Aldrich syndrome protein (N-WASP) and cortactin during branched actin filament network formation. (PubMed id 12732638)1, 9 Uruno T....Zhan X. (J. Biol. Chem. 2003)
    10. Involvement of Arp2/3 complex in MCP-1-induced chemotaxis. (PubMed id 16004967)1, 9 Mukai Y....Mukai K. (Biochem. Biophys. Res. Commun. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10097 HGNC: 169 AceView: ACTR2 Ensembl:ENSG00000138071 euGenes: HUgn10097
    ECgene: ACTR2 H-InvDB: ACTR2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ACTR2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ACTR2 gene:
    Search GeneIP for patents involving ACTR2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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