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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ACTR2 Gene

protein-coding   GIFtS: 62
GCID: GC02P065454

ARP2 actin-related protein 2 homolog (yeast)

(Previous names: ARP2 (actin-related protein 2, yeast) homolog )
 Explore 10 diseases affiliated with
ACTR2 via our new
 Human Malady Compendium 
Biological research products
for ACTR2
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
ARP2 Actin-Related Protein 2 Homolog (Yeast)1 2
ARP21 2 3
Actin-Like Protein 22 3
ARP2 (Actin-Related Protein 2, Yeast) Homolog1
Actin-Related Protein 22

External Ids:    HGNC: 1691   Entrez Gene: 100972   Ensembl: ENSG000001380717   OMIM: 6042215   UniProtKB: P611603   

Export aliases for ACTR2 gene to outside databases

Previous GC identifers: GC02P065588 GC02P065412 GC02P065429 GC02P065366 GC02P065308 GC02P065189


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ACTR2:
The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a major
constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and
motility through lamellipodial actin assembly and protrusion. Two transcript variants encoding different isoforms have
been found for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ARP2_HUMAN, P61160
Function: Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin
polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched
actin networks. Seems to contact the pointed end of the daughter actin filament

Gene Wiki entry for ACTR2


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_022184.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ACTR2 gene promoter:
         c-Fos   AP-1   p53   JunB   Fra-1   FosB   YY1   JunD   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidACTR2 promoter sequence
   Search SABiosciences Chromatin IP Primers for ACTR2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ACTR2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p14   Ensembl cytogenetic band:  2p14   HGNC cytogenetic band: 2p14

ACTR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ACTR2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P065454:  view genomic region     (about GC identifiers)

Start:
65,454,829 bp from pter      End:
65,498,387 bp from pter
Size:
43,559 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ARP2_HUMAN, P61160 (See protein sequence)
Recommended Name: Actin-related protein 2  
Size: 394 amino acids; 44761 Da
Subunit: Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC,
ARPC4/p20-ARC and ARPC5/p16-ARC
Subcellular location: Cytoplasm, cytoskeleton. Cell projection
Secondary accessions: B2RCP5 D6W5F4 E9PF41 O15142 Q96C82
Alternative splicing: 2 isoforms:  P61160-1   P61160-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ACTR2: NX_P61160

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P61160

  • ACTR2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001005386.1  NP_005713.1  

    ENSEMBL proteins: 
     ENSP00000260641   ENSP00000367220   ENSP00000437383  
    Reactome Protein details: P61160
    Human Recombinant Protein Products: 
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    Uscn Proteins for ACTR2

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005885Arp2/3 protein complex TAS9230079
    GO:0005938cell cortex ----
    GO:0015629actin cytoskeleton TAS9230079
    GO:0030478actin cap ----


    ACTR2 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ACTR2 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR004000 Actin-related
     IPR020902 Actin/actin-like_CS

    Graphical View of Domain Structure for InterPro Entry P61160

    ProtoNet protein and cluster: P61160

    UniProtKB/Swiss-Prot: ARP2_HUMAN, P61160
    Similarity: Belongs to the actin family. ARP2 subfamily


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: ARP2_HUMAN, P61160
    Function: Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin
    polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched
    actin networks. Seems to contact the pointed end of the daughter actin filament

    miRNA
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    hsa-miR-607 hsa-miR-4254 hsa-miR-3146 hsa-miR-24-1* hsa-miR-15a hsa-miR-503 hsa-miR-890 hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidACTR2 3' UTR sequence
    Inhib. RNA
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0005524ATP binding IEA--


    ACTR2 for ontologies           About GeneDecksing


    5 GenomeRNAi human phenotypes for ACTR2:
     Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella-containin 
     Synthetic lethal with Ras 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/26 super-pathways (see all 26About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cell adhesion_Integrin-mediated cell adhesion and migration
    Cell adhesion_Integrin-mediated cell adhesion and migration1.00
    Cytoskeleton remodeling_Integrin outside-in signaling0.37
    Cell adhesion Integrin-mediated cell adhesion and migration1.00
    Cytoskeleton remodeling Integrin outside-in signaling0.37
    Cytoskeleton remodeling_Regulation of actin cytoskeleton by Rho GTPases0.49
    Cytoskeleton remodeling Fibronectin-binding integrins in cell motility0.32
    Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases0.49
    Cytoskeleton remodeling_Fibronectin-binding integrins in cell motility0.32
    2G-protein signaling_RAC1 in cellular process
    G-protein signaling_RAC1 in cellular process1.00
    Cytoskeleton remodeling CDC42 in cellular processes0.37
    G-protein signaling RAC1 in cellular process1.00
    RAC1 signaling pathway0.34
    Cytoskeleton remodeling_CDC42 in cellular processes0.37
    CDC42 signaling events0.17
    3Regulation of actin dynamics for phagocytic cup formation
    Regulation of actin dynamics for phagocytic cup formation1.00
    Fcgamma receptor (FCGR) dependent phagocytosis0.80
    Role of myosins in phagosome formation0.80
    Branching and elongation of mother and daughter filaments0.29
    4Cytoskeleton remodeling Slit-Robo signaling
    Cytoskeleton remodeling Slit-Robo signaling1.00
    Cell adhesion_Cadherin-mediated cell adhesion0.28
    Development_Slit-Robo signaling0.92
    Cell adhesion Cadherin-mediated cell adhesion0.28
    5Immune response CD16 signaling in NK cells
    Immune response CD16 signaling in NK cells1.00
    Immune response_Role of DAP12 receptors in NK cells0.32
    Immune response_CD16 signaling in NK cells0.99
    Immune response Role of DAP12 receptors in NK cells0.32

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/13 EMD Millipore Pathways for ACTR2 (see all 13)
        Cytoskeleton remodeling Integrin outside-in signaling
    Immune response CD16 signaling in NK cells
    Cytoskeleton remodeling CDC42 in cellular processes
    Cytoskeleton remodeling Fibronectin-binding integrins in cell motility
    Immune response Role of DAP12 receptors in NK cells

    5/20 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ACTR2 (see all 20)
        RhoA Pathway
    Actin-Based Motility by Rho Family GTPases
    Remodeling of Adherens Junctions
    Guidance Cues and Growth Cone Motility
    Signaling by Slit

    1 Cell Signaling Technology (CST) Pathway for ACTR2
        Cytoskeletal Signaling

    5/14 GeneGo (Thomson Reuters) Pathways for ACTR2 (see all 14)
        Cytoskeleton remodeling CDC42 in cellular processes
    Immune response CD16 signaling in NK cells
    Cytoskeleton remodeling Fibronectin-binding integrins in cell motility
    Neurophysiological process Receptor-mediated axon growth repulsion
    Cytoskeleton remodeling Integrin outside-in signaling

    4 BioSystems Pathways for ACTR2 
        B Cell Receptor Signaling Pathway
    CDC42 signaling events
    RAC1 signaling pathway
    ErbB1 downstream signaling

    5/6        Reactome Pathways for ACTR2 (see all 6)
        Role of myosins in phagosome formation
    Branching and elongation of mother and daughter filaments
    Regulation of actin dynamics for phagocytic cup formation
    Fcgamma receptor (FCGR) dependent phagocytosis
    Immune System



    ACTR2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ACTR2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/897 Interacting proteins for ACTR2 (P611602, 3 ENSP000003672204) via UniProtKB, MINT, STRING, and/or I2D (see all 897)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACTBP607092, 3, ENSP000003499604MINT-7945693 MINT-7947479 I2D: score=2 STRING: ENSP00000349960
    CCT5P486432, 3MINT-7945693 MINT-7947479 I2D: score=4 
    CCT8P509902, 3MINT-7945693 MINT-7947479 I2D: score=4 
    PSMC4P436862, 3MINT-7945693 MINT-7947479 I2D: score=4 
    DIAPH1O606102, 3MINT-7945693 MINT-7947479 I2D: score=3 
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006928cellular component movement TAS9230079
    GO:0007163establishment or maintenance of cell polarity ----
    GO:0008356asymmetric cell division ----
    GO:0016482cytoplasmic transport ----
    GO:0030036actin cytoskeleton organization ----


    ACTR2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ACTR2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for ACTR2

    2 DrugBank Compounds for ACTR2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one-- --target--10592235
    N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide-- --target--10592235

    1 Novoseek chemical compound relationship for ACTR2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    atp 4.2 5 11752435 (3), 17251352 (1)

    Search CenterWatch for drugs/clinical trials and news about ACTR2 / ARP2 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ACTR2 gene (2 alternative transcripts): 
    NM_001005386.2  NM_005722.3  

    Unigene Cluster for ACTR2:

    ARP2 actin-related protein 2 homolog (yeast)
    Hs.643727  [show with all ESTs]
    Unigene Representative Sequence: NM_001005386
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000260641(uc002sdp.3 uc002sdq.3 uc010yqg.2) ENST00000476840
    ENST00000471552 ENST00000377982 ENST00000542850(uc010yqf.1)

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    Additional cDNA sequence: 

    AB462501.1 AF006082.1 AK025051.1 AK295157.1 AK301634.1 AK315205.1 AL049356.1 BC014546.1 
    BC036253.1 BX649080.1 

    24/29 DOTS entries (see all 29):

    DT.101961003  DT.95156078  DT.75189376  DT.100877083  DT.100877089  DT.95245735  DT.100877084  DT.100877085 
    DT.97801854  DT.95074926  DT.121011729  DT.100877090  DT.97791493  DT.99926655  DT.100877081  DT.120826962 
    DT.121011721  DT.121011735  DT.121011742  DT.121011911  DT.121011966  DT.121493112  DT.92454903  DT.97760126 

    24/845 AceView cDNA sequences (see all 845):

    AL706073 BM793128 BM090816 BF325851 BP346190 AA205368 BX646626 BM452012 
    AI567774 BU186139 BU542055 F03430 AI126880 AI688242 BU629218 AA663066 
    AW169477 AW504578 F07421 CR593126 AL710875 BU682767 BU616817 BX485727 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ACTR2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAATACTTCA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See ACTR2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ACTR2

    SOURCE GeneReport for Unigene cluster: Hs.643727
        SABiosciences Expression via Pathway-Focused PCR Arrays including ACTR2: 
              Cytoskeleton Regulators in human mouse rat
              EGF / PDGF Signaling Pathway in human mouse rat
              Cell Motility in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACTR2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ACTR2 gene from 9/35 species (see all 35)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves ACTR21 ARP2 actin-related protein 2 homolog (yeast) 85.45(n)
    98.98(a)
      396147  NM_205224.1  NP_990555.1 
    lizard
    (Anolis carolinensis)
    Reptilia ACTR26
    ACTRT36
    (see all 4)
    --
    99(a)
    43(a)
    (see all 4)
    1 ↔ 1
    possible ortholog
    (see all 4)
    1(124520485-124546286)
    3(8001296-8005919)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC043992.12   -- 84.75(n)    BC043992.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC055220.12   -- 78.26(n)    BC055220.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Arp14D1 , 3 cytoskeleton organization and biogenesis
    structural more3
    Actin-related protein 14D1
    81(a)3
    67.78(n)1
    82.52(a)1
      14E13
    326231  NM_001103531.11  NP_001097001.11 
    worm
    (Caenorhabditis elegans)
    Secernentea arx-21 Protein ARX-2 66.84(n)
    76.47(a)
      179440  NM_073256.5  NP_505657.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ARP2(YDL029W)4
    ARP21
    Essential component of the Arp2/3 complex, which is more4
    Arp2p1
    62.92(n)1
    67.62(a)1
      4(399340-400638)4
    8515321, 4  NP_010255.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ARP21 actin related protein 2 60.14(n)
    62.92(a)
      822317  NM_113614.2  NP_189336.1 
    rice
    (Oryza sativa)
    Liliopsida Os08g03693001 hypothetical protein 60.38(n)
    60.86(a)
      4345402  NM_001068190.2  NP_001061655.2 


    ENSEMBL Gene Tree for ACTR2 (if available)
    TreeFam Gene Tree for ACTR2 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ACTR2 gene
    ACTL82  ACTL102  
    18/29 SIMAP similar genes for ACTR2 using alignment to 3 protein entries:     ARP2_HUMAN (see all proteins) (see all similar genes):
    ACTB    ACTG1    ACT    ACTR1B    ACTA2    PS1TP5BP1
    ACTBL2    ACTC1    POTEKP    POTEI    POTEJ    ACTG2
    POTEE    POTEF    ACTR1A    ACTR6    ACTL6B    ACTRT1

    ACTR2 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for ACTR2
    PGOHUM00000256847 PGOHUM00000246543


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/822 NCBI SNPs in ACTR2 are shown (see all 822    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1866361331,2
    --65452876(+) TTATAA/GTAAGT 2 -- us2k10--------
    rs1915338891,2
    --65453004(+) TTTGAA/GACAGA 2 -- us2k10--------
    rs1392555651,2
    --65453088(+) GATTCA/TCCTGC 2 -- us2k10--------
    rs1829113381,2
    --65453123(+) TACAGA/GCGCGT 2 -- us2k10--------
    rs1852208761,2
    --65453124(+) ACAGGC/GGCGTG 2 -- us2k10--------
    rs1896936711,2
    --65453197(+) CTTGTC/TTTGAA 2 -- us2k10--------
    rs134281091,2
    C,--65453294(+) TTCTTC/TAAAAA 2 -- us2k1 trp30--------
    rs134148831,2
    C,F,--65453444(+) GATACG/AGACTC 2 -- us2k17Minor allele frequency- A:0.38NA WA CSA 247
    rs763967071,2
    F,--65453555(+) CCTACC/GTATTC 2 -- us2k11Minor allele frequency- G:0.03WA 118
    rs349616851,2
    C,F,--65453723(+) NNNNGC/TAGCTA 2 -- us2k13Minor allele frequency- T:0.23NA 124

    HapMap Linkage Disequilibrium report for ACTR2 (65454829 - 65498387 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ACTR2: --

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ACTR2 for disorders           About GeneDecksing

    OMIM gene information: 604221    OMIM disorders: --

    10 diseases for ACTR2:    About MalaCards
    wiskott-aldrich syndrome    gastric adenocarcinoma    vaccinia    breast carcinoma
    adenocarcinoma    breast cancer    melanoma    carcinoma
    hepatitis    neuronitis

    1 disease from the University of Copenhagen DISEASES database for ACTR2:
    Wiskott-Aldrich syndrome

    4 Novoseek disease relationships for ACTR2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    wiskott-aldrich syndrome 79 4 16638851 (2), 11598103 (1), 17277766 (1)
    metastasis 0.743 8 17459058 (4), 16638851 (2)
    tumors 0 4 14990971 (3), 16638851 (1)
    cancer 0 6 17459058 (3), 16638851 (3)

    Human Genome Epidemiology (HuGE) Navigator: ACTR2 (1 document)

    Export disorders for ACTR2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ACTR2 gene, integrated from 9 sources (see all 113):
    (articles sorted by number of sources associating them with ACTR2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly. (PubMed id 9230079)1, 2, 3 Welch M.D.... Mitchison T.J. (1997)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Reconstitution of human Arp2/3 complex reveals critical roles of individual subunits in complex structure and activity. (PubMed id 11741539)1, 2 Gournier H.... Welch M.D. (2001)
    4. Actin polymerization is induced by Arp2/3 protein complex at the surface of Listeria monocytogenes. (PubMed id 9000076)1, 2 Welch M.D.... Mitchison T.J. (1997)
    5. Coexpression of actin-related protein 2 and Wiskott-Aldrich syndrome family verproline-homologous protein 2 in adenocarcinoma of the lung. (PubMed id 16638851)1, 9 Semba S....Mukai K. (2006)
    6. Correlation between liver metastasis of the colocalization of actin-related protein 2 and 3 complex and WAVE2 in colorectal carcinoma. (PubMed id 17459058)1, 9 Iwaya K....Mukai K. (2007)
    7. Actin-related protein (Arp2) inserts into artificial lipid membranes. (PubMed id 12468383)1, 9 Goldmann W.H. and Isenberg G. (2002)
    8. Interaction of cortactin and N-WASp with Arp2/3 complex. (PubMed id 12176354)1, 9 Weaver A.M....Cooper J.A. (2002)
    9. Involvement of Arp2/3 complex in MCP-1-induced chemotaxis. (PubMed id 16004967)1, 9 Mukai Y....Mukai K. (2005)
    10. The adapter protein CrkII regulates neuronal Wiskott-Aldrich syndrome protein, actin polymerization, and tension development during contractile stimulation of smooth muscle. (PubMed id 15834156)1, 9 Tang D.D....Gunst S.J. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10097 HGNC: 169 AceView: ACTR2 Ensembl:ENSG00000138071 euGenes: HUgn10097
    ECgene: ACTR2 H-InvDB: ACTR2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ACTR2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ACTR2 gene:
    Search GeneIP for patents involving ACTR2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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