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Aliases for ACTR2 Gene

Aliases for ACTR2 Gene

  • ARP2 Actin-Related Protein 2 Homolog (Yeast) 2 3
  • Actin-Like Protein 2 3 4
  • ARP2 3 4
  • ARP2 (Actin-Related Protein 2, Yeast) Homolog 2
  • Actin-Related Protein 2 3

External Ids for ACTR2 Gene

Previous GeneCards Identifiers for ACTR2 Gene

  • GC02P065588
  • GC02P065412
  • GC02P065429
  • GC02P065366
  • GC02P065308
  • GC02P065454
  • GC02P065189

Summaries for ACTR2 Gene

Entrez Gene Summary for ACTR2 Gene

  • The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and motility through lamellipodial actin assembly and protrusion. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for ACTR2 Gene

ACTR2 (ARP2 Actin-Related Protein 2 Homolog (Yeast)) is a Protein Coding gene. Diseases associated with ACTR2 include wiskott-aldrich syndrome. Among its related pathways are RhoGDI Pathway and ERK Signaling. GO annotations related to this gene include actin binding. An important paralog of this gene is ACTL7B.

UniProtKB/Swiss-Prot for ACTR2 Gene

  • Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament.

Gene Wiki entry for ACTR2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACTR2 Gene

Genomics for ACTR2 Gene

Regulatory Elements for ACTR2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ACTR2 Gene

Start:
65,227,695 bp from pter
End:
65,271,253 bp from pter
Size:
43,559 bases
Orientation:
Plus strand

Genomic View for ACTR2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ACTR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACTR2 Gene

Proteins for ACTR2 Gene

  • Protein details for ACTR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61160-ARP2_HUMAN
    Recommended name:
    Actin-related protein 2
    Protein Accession:
    P61160
    Secondary Accessions:
    • B2RCP5
    • D6W5F4
    • E9PF41
    • O15142
    • Q96C82

    Protein attributes for ACTR2 Gene

    Size:
    394 amino acids
    Molecular mass:
    44761 Da
    Quaternary structure:
    • Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.

    Alternative splice isoforms for ACTR2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ACTR2 Gene

Proteomics data for ACTR2 Gene at MOPED

Post-translational modifications for ACTR2 Gene

  • Ubiquitination at Lys7, Lys19, Lys46, Lys53, Lys86, Lys97, Lys106, Lys118, Lys195, Lys219, Lys299, Lys322, Lys336, Lys366, Lys368, Lys381, and Lys388
  • Modification sites at PhosphoSitePlus

Other Protein References for ACTR2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ACTR2 Gene

Domains for ACTR2 Gene

Protein Domains for ACTR2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ACTR2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P61160

UniProtKB/Swiss-Prot:

ARP2_HUMAN :
  • P61160
Family:
  • Belongs to the actin family. ARP2 subfamily.
genes like me logo Genes that share domains with ACTR2: view

No data available for Gene Families for ACTR2 Gene

Function for ACTR2 Gene

Molecular function for ACTR2 Gene

UniProtKB/Swiss-Prot Function: Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament.

Gene Ontology (GO) - Molecular Function for ACTR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005200 structural constituent of cytoskeleton IDA 11741539
GO:0005524 ATP binding IEA --
GO:0051015 contributes_to actin filament binding IDA 11741539
genes like me logo Genes that share ontologies with ACTR2: view
genes like me logo Genes that share phenotypes with ACTR2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ACTR2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ACTR2 Gene

Localization for ACTR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACTR2 Gene

Cytoplasm, cytoskeleton. Cell projection.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ACTR2 Gene COMPARTMENTS Subcellular localization image for ACTR2 gene
Compartment Confidence
cytoskeleton 5
cytosol 4
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ACTR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 22684256
GO:0005829 cytosol TAS --
GO:0005885 Arp2/3 protein complex TAS 9230079
GO:0005925 focal adhesion IDA 21423176
GO:0005938 cell cortex --
genes like me logo Genes that share ontologies with ACTR2: view

Pathways for ACTR2 Gene

genes like me logo Genes that share pathways with ACTR2: view

PCR Array Products

Gene Ontology (GO) - Biological Process for ACTR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006928 movement of cell or subcellular component TAS 9230079
GO:0007163 establishment or maintenance of cell polarity IEA --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0007411 axon guidance TAS --
GO:0008356 asymmetric cell division IEA --
genes like me logo Genes that share ontologies with ACTR2: view

Compounds for ACTR2 Gene

(2) Drugbank Compounds for ACTR2 Gene

(1) Novoseek inferred chemical compound relationships for ACTR2 Gene

Compound -log(P) Hits PubMed IDs
atp 4.2 4
genes like me logo Genes that share compounds with ACTR2: view

Transcripts for ACTR2 Gene

Unigene Clusters for ACTR2 Gene

ARP2 actin-related protein 2 homolog (yeast):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ACTR2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ACTR2 Gene

No ASD Table

Relevant External Links for ACTR2 Gene

GeneLoc Exon Structure for
ACTR2
ECgene alternative splicing isoforms for
ACTR2

Expression for ACTR2 Gene

mRNA expression in normal human tissues for ACTR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ACTR2 Gene

This gene is overexpressed in Whole Blood (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ACTR2 Gene

SOURCE GeneReport for Unigene cluster for ACTR2 Gene Hs.744913

genes like me logo Genes that share expressions with ACTR2: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ACTR2 Gene

Orthologs for ACTR2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ACTR2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ACTR2 35
  • 99.83 (n)
  • 100 (a)
ACTR2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ACTR2 35
  • 93.99 (n)
  • 100 (a)
ACTR2 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ACTR2 35
  • 94.99 (n)
  • 100 (a)
ACTR2 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Actr2 35
  • 92.22 (n)
  • 100 (a)
Actr2 16
Actr2 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ACTR2 36
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ACTR2 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Actr2 35
  • 90.78 (n)
  • 99.75 (a)
chicken
(Gallus gallus)
Aves ACTR2 35
  • 85.45 (n)
  • 98.98 (a)
ACTR2 36
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ACTR2 36
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia actr2 35
  • 82.15 (n)
  • 98.48 (a)
zebrafish
(Danio rerio)
Actinopterygii actr2a 35
  • 77.92 (n)
  • 96.95 (a)
actr2b 36
  • 96 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000985 35
  • 68.38 (n)
  • 82.31 (a)
fruit fly
(Drosophila melanogaster)
Insecta Arp14D 36
  • 80 (a)
OneToOne
Arp2 35
  • 67.17 (n)
  • 81.47 (a)
Arp14D 37
  • 81 (a)
worm
(Caenorhabditis elegans)
Secernentea arx-2 35
  • 66.84 (n)
  • 76.47 (a)
arx-2 36
  • 76 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR316W 35
  • 59.47 (n)
  • 65.55 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARP2 35
  • 63.01 (n)
  • 67.89 (a)
ARP2 36
  • 67 (a)
OneToMany
ARP2 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C03850g 35
  • 62.84 (n)
  • 67.1 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.11919 35
soybean
(Glycine max)
eudicotyledons Gma.7173 35
thale cress
(Arabidopsis thaliana)
eudicotyledons ARP2 35
  • 60.07 (n)
  • 62.76 (a)
rice
(Oryza sativa)
Liliopsida Os08g0369300 35
  • 60.75 (n)
  • 60.85 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU07171 35
  • 62.03 (n)
  • 70.6 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes arp2 35
  • 62.47 (n)
  • 66.4 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11313 36
  • 78 (a)
OneToOne
Species with no ortholog for ACTR2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ACTR2 Gene

ENSEMBL:
Gene Tree for ACTR2 (if available)
TreeFam:
Gene Tree for ACTR2 (if available)

Paralogs for ACTR2 Gene

Paralogs for ACTR2 Gene

Pseudogenes.org Pseudogenes for ACTR2 Gene

genes like me logo Genes that share paralogs with ACTR2: view

Variants for ACTR2 Gene

Sequence variations from dbSNP and Humsavar for ACTR2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs7246 -- 65,270,500(+) TCTTA(C/T)ATAAA utr-variant-3-prime
rs7247 -- 65,271,206(+) ATGAA(A/G)TACTT utr-variant-3-prime
rs8771 -- 65,268,941(-) TCTAT(A/G)TAGGG utr-variant-3-prime
rs10116 -- 65,269,595(-) TAATT(C/T)GAATT utr-variant-3-prime
rs10717 -- 65,271,161(-) TCAAG(A/C)TACTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ACTR2 Gene

Variant ID Type Subtype PubMed ID
nsv527241 CNV Loss 19592680

Relevant External Links for ACTR2 Gene

HapMap Linkage Disequilibrium report
ACTR2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACTR2 Gene

Disorders for ACTR2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for ACTR2 Gene including...

Search for ACTR2 Gene in MalaCards »

(1) University of Copenhagen DISEASES for ACTR2 Gene

(4) Novoseek inferred disease relationships for ACTR2 Gene

Disease -log(P) Hits PubMed IDs
wiskott-aldrich syndrome 79 4
metastasis 0.743 6
tumors 0 4
cancer 0 6

Relevant External Links for ACTR2

Human Genome Epidemiology (HuGE) Navigator
ACTR2
genes like me logo Genes that share disorders with ACTR2: view

No data available for UniProtKB/Swiss-Prot for ACTR2 Gene

Publications for ACTR2 Gene

  1. The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly. (PMID: 9230079) Welch M.D. … Mitchison T.J. (J. Cell Biol. 1997) 2 3 4
  2. Correlation between liver metastasis of the colocalization of actin-related protein 2 and 3 complex and WAVE2 in colorectal carcinoma. (PMID: 17459058) Iwaya K. … Mukai K. (Cancer Sci. 2007) 3 23
  3. Coexpression of actin-related protein 2 and Wiskott-Aldrich syndrome family verproline-homologous protein 2 in adenocarcinoma of the lung. (PMID: 16638851) Semba S. … Mukai K. (Clin. Cancer Res. 2006) 3 23
  4. Reconstitution of human Arp2/3 complex reveals critical roles of individual subunits in complex structure and activity. (PMID: 11741539) Gournier H. … Welch M.D. (Mol. Cell 2001) 3 4
  5. Interaction of cortactin and N-WASp with Arp2/3 complex. (PMID: 12176354) Weaver A.M. … Cooper J.A. (Curr. Biol. 2002) 3 23

Products for ACTR2 Gene

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