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Aliases for ACTR2 Gene

Aliases for ACTR2 Gene

  • ARP2 Actin Related Protein 2 Homolog 2 3 5
  • Actin-Like Protein 2 3 4
  • ARP2 3 4
  • ARP2 (Actin-Related Protein 2, Yeast) Homolog 2
  • ARP2 Actin-Related Protein 2 Homolog (Yeast) 2
  • Actin-Related Protein 2 3

External Ids for ACTR2 Gene

Previous GeneCards Identifiers for ACTR2 Gene

  • GC02P065588
  • GC02P065412
  • GC02P065429
  • GC02P065366
  • GC02P065308
  • GC02P065454
  • GC02P065189

Summaries for ACTR2 Gene

Entrez Gene Summary for ACTR2 Gene

  • The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and motility through lamellipodial actin assembly and protrusion. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for ACTR2 Gene

ACTR2 (ARP2 Actin Related Protein 2 Homolog) is a Protein Coding gene. Diseases associated with ACTR2 include Wiskott-Aldrich Syndrome. Among its related pathways are ICos-ICosL Pathway in T-Helper Cell and Immune response CCR3 signaling in eosinophils. GO annotations related to this gene include actin filament binding and structural constituent of cytoskeleton.

UniProtKB/Swiss-Prot for ACTR2 Gene

  • Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament.

Gene Wiki entry for ACTR2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACTR2 Gene

Genomics for ACTR2 Gene

Regulatory Elements for ACTR2 Gene

Enhancers for ACTR2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G065277 1.1 Ensembl ENCODE 23.2 +51.2 51172 1.8 ELF3 PKNOX1 FOXA2 ARID4B RARA GATA2 ETV6 MIXL1 EGR2 ZNF263 ACTR2 SPRED2 LOC105374780 GC02P065254 GC02P065309
GH02G065055 1.6 Ensembl ENCODE dbSUPER 9.6 -170.3 -170268 5.1 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 WRNIP1 ARID4B SIN3A FEZF1 CEP68 RAB1A RNU6-548P ACTR2 LOC105374779
GH02G065060 1.5 Ensembl ENCODE dbSUPER 9.7 -164.2 -164178 5.8 HDGF PKNOX1 FOXA2 ATF1 WRNIP1 FEZF1 TCF12 ZNF121 ZNF766 ZNF143 CEP68 RAB1A RNU6-548P ACTR2 LOC105374779
GH02G065126 1.4 ENCODE dbSUPER 9.9 -97.5 -97473 8.2 MLX CREB3L1 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21 CEP68 LOC102724233 ACTR2 SERTAD2 RAB1A GC02P065109
GH02G064851 1.8 FANTOM5 Ensembl ENCODE dbSUPER 7.6 -374.0 -373977 3.8 PKNOX1 ATF1 TCF12 ZNF766 GATA2 ELK1 FOS CAVIN1 REST ZNF592 RAB1A ACTR2 LINC01800 SLC1A4 AFTPH SERTAD2 GC02P064841
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ACTR2 on UCSC Golden Path with GeneCards custom track

Promoters for ACTR2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000118086 505 2801 PKNOX1 ARNT WRNIP1 ARID4B SIN3A FEZF1 DMAP1 YY1 SLC30A9 ZNF207

Genomic Location for ACTR2 Gene

Chromosome:
2
Start:
65,227,695 bp from pter
End:
65,271,253 bp from pter
Size:
43,559 bases
Orientation:
Plus strand

Genomic View for ACTR2 Gene

Genes around ACTR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACTR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACTR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACTR2 Gene

Proteins for ACTR2 Gene

  • Protein details for ACTR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61160-ARP2_HUMAN
    Recommended name:
    Actin-related protein 2
    Protein Accession:
    P61160
    Secondary Accessions:
    • B2RCP5
    • D6W5F4
    • E9PF41
    • O15142
    • Q96C82

    Protein attributes for ACTR2 Gene

    Size:
    394 amino acids
    Molecular mass:
    44761 Da
    Quaternary structure:
    • Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.

    Alternative splice isoforms for ACTR2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ACTR2 Gene

Post-translational modifications for ACTR2 Gene

  • Ubiquitination at posLast=77, posLast=1919, posLast=4646, posLast=5353, posLast=8686, posLast=9797, posLast=106106, Lys195, posLast=219219, posLast=336336, Lys366, posLast=368368, Lys381, and posLast=388388
  • Modification sites at PhosphoSitePlus

Other Protein References for ACTR2 Gene

No data available for DME Specific Peptides for ACTR2 Gene

Domains & Families for ACTR2 Gene

Protein Domains for ACTR2 Gene

Suggested Antigen Peptide Sequences for ACTR2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P61160

UniProtKB/Swiss-Prot:

ARP2_HUMAN :
  • Belongs to the actin family. ARP2 subfamily.
Family:
  • Belongs to the actin family. ARP2 subfamily.
genes like me logo Genes that share domains with ACTR2: view

Function for ACTR2 Gene

Molecular function for ACTR2 Gene

UniProtKB/Swiss-Prot Function:
Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament.

Gene Ontology (GO) - Molecular Function for ACTR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005200 structural constituent of cytoskeleton IDA 11741539
GO:0005524 ATP binding IEA --
GO:0008092 cytoskeletal protein binding IEA --
GO:0051015 contributes_to actin filament binding IDA 11741539
genes like me logo Genes that share ontologies with ACTR2: view
genes like me logo Genes that share phenotypes with ACTR2: view

Animal Model Products

CRISPR Products

miRNA for ACTR2 Gene

miRTarBase miRNAs that target ACTR2

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ACTR2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ACTR2 Gene

Localization for ACTR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACTR2 Gene

Cytoplasm, cytoskeleton. Cell projection.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ACTR2 gene
Compartment Confidence
extracellular 5
cytoskeleton 5
cytosol 5
lysosome 4
plasma membrane 1
mitochondrion 1
peroxisome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ACTR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002102 podosome IEA --
GO:0005576 extracellular region TAS --
GO:0005737 cytoplasm IDA 22684256
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with ACTR2: view

Pathways & Interactions for ACTR2 Gene

genes like me logo Genes that share pathways with ACTR2: view

SIGNOR curated interactions for ACTR2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for ACTR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006928 movement of cell or subcellular component TAS 9230079
GO:0007015 actin filament organization IEA --
GO:0007163 establishment or maintenance of cell polarity IEA --
GO:0008306 associative learning IEA --
GO:0008356 asymmetric cell division IEA --
genes like me logo Genes that share ontologies with ACTR2: view

Drugs & Compounds for ACTR2 Gene

(3) Drugs for ACTR2 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
(2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one Experimental Pharma Target 0
N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide Experimental Pharma Target 0
genes like me logo Genes that share compounds with ACTR2: view

Transcripts for ACTR2 Gene

Unigene Clusters for ACTR2 Gene

ARP2 actin-related protein 2 homolog (yeast):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ACTR2

Alternative Splicing Database (ASD) splice patterns (SP) for ACTR2 Gene

No ASD Table

Relevant External Links for ACTR2 Gene

GeneLoc Exon Structure for
ACTR2
ECgene alternative splicing isoforms for
ACTR2

Expression for ACTR2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ACTR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ACTR2 Gene

This gene is overexpressed in Whole Blood (x4.4).

Protein differential expression in normal tissues from HIPED for ACTR2 Gene

This gene is overexpressed in Spleen (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ACTR2 Gene



Protein tissue co-expression partners for ACTR2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ACTR2 Gene:

ACTR2

SOURCE GeneReport for Unigene cluster for ACTR2 Gene:

Hs.744913

Evidence on tissue expression from TISSUES for ACTR2 Gene

  • Muscle(4.6)
  • Nervous system(4.6)
  • Liver(4.4)
  • Lymph node(2.5)
  • Spleen(2.4)
  • Heart(2.3)
  • Lung(2.3)
  • Blood(2.2)
  • Eye(2.1)
  • Intestine(2)
genes like me logo Genes that share expression patterns with ACTR2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ACTR2 Gene

Orthologs for ACTR2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ACTR2 Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia ACTR2 35
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ACTR2 34 35
  • 99.83 (n)
dog
(Canis familiaris)
Mammalia ACTR2 35 34
  • 94.99 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ACTR2 34 35
  • 93.99 (n)
mouse
(Mus musculus)
Mammalia Actr2 16 35 34
  • 92.22 (n)
rat
(Rattus norvegicus)
Mammalia Actr2 34
  • 90.78 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ACTR2 35
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves ACTR2 34 35
  • 85.45 (n)
lizard
(Anolis carolinensis)
Reptilia ACTR2 35
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia actr2 34
  • 82.15 (n)
zebrafish
(Danio rerio)
Actinopterygii actr2b 35
  • 96 (a)
OneToOne
actr2a 34
  • 77.92 (n)
fruit fly
(Drosophila melanogaster)
Insecta Arp14D 36 35
  • 81 (a)
Arp2 34
  • 67.17 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000985 34
  • 68.38 (n)
worm
(Caenorhabditis elegans)
Secernentea arx-2 34 35
  • 66.84 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARP2 34 35 37
  • 63.01 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C03850g 34
  • 62.84 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR316W 34
  • 59.47 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons ARP2 34
  • 60.07 (n)
soybean
(Glycine max)
eudicotyledons Gma.7173 34
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.11919 34
rice
(Oryza sativa)
Liliopsida Os08g0369300 34
  • 60.75 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11313 35
  • 78 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes arp2 34
  • 62.47 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU07171 34
  • 62.03 (n)
Species where no ortholog for ACTR2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ACTR2 Gene

ENSEMBL:
Gene Tree for ACTR2 (if available)
TreeFam:
Gene Tree for ACTR2 (if available)

Paralogs for ACTR2 Gene

Pseudogenes.org Pseudogenes for ACTR2 Gene

genes like me logo Genes that share paralogs with ACTR2: view

No data available for Paralogs for ACTR2 Gene

Variants for ACTR2 Gene

Sequence variations from dbSNP and Humsavar for ACTR2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000149032 -- 65,251,793(+) AAGGT(A/G)AACAT intron-variant
rs1000197628 -- 65,249,204(+) GTACA(C/T)ATTTT intron-variant
rs1000205038 -- 65,263,713(+) TTGTT(C/T)TTTGA intron-variant
rs1000223679 -- 65,266,992(+) ATGAG(C/T)GAGAT intron-variant
rs1000314381 -- 65,246,067(+) TCATT(A/G)TGCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ACTR2 Gene

Variant ID Type Subtype PubMed ID
nsv1131470 CNV deletion 24896259
nsv527241 CNV loss 19592680
nsv961411 CNV duplication 23825009

Variation tolerance for ACTR2 Gene

Residual Variation Intolerance Score: 29.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.07; 1.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ACTR2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ACTR2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACTR2 Gene

Disorders for ACTR2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ACTR2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
wiskott-aldrich syndrome
  • wiskott syndrome
- elite association - COSMIC cancer census association via MalaCards
Search ACTR2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ACTR2

Human Genome Epidemiology (HuGE) Navigator
ACTR2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ACTR2
genes like me logo Genes that share disorders with ACTR2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ACTR2 Gene

Publications for ACTR2 Gene

  1. The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly. (PMID: 9230079) Welch M.D. … Mitchison T.J. (J. Cell Biol. 1997) 2 3 4 64
  2. Correlation between liver metastasis of the colocalization of actin-related protein 2 and 3 complex and WAVE2 in colorectal carcinoma. (PMID: 17459058) Iwaya K. … Mukai K. (Cancer Sci. 2007) 3 22 64
  3. Coexpression of actin-related protein 2 and Wiskott-Aldrich syndrome family verproline-homologous protein 2 in adenocarcinoma of the lung. (PMID: 16638851) Semba S. … Mukai K. (Clin. Cancer Res. 2006) 3 22 64
  4. The adapter protein CrkII regulates neuronal Wiskott-Aldrich syndrome protein, actin polymerization, and tension development during contractile stimulation of smooth muscle. (PMID: 15834156) Tang D.D. … Gunst S.J. (J. Biol. Chem. 2005) 3 22 64
  5. Involvement of Arp2/3 complex in MCP-1-induced chemotaxis. (PMID: 16004967) Mukai Y. … Mukai K. (Biochem. Biophys. Res. Commun. 2005) 3 22 64

Products for ACTR2 Gene

  • Addgene plasmids for ACTR2

Sources for ACTR2 Gene

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