Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ACTR1B Gene

protein-coding   GIFtS: 60
GCID: GC02M098272

ARP1 actin-related protein 1 homolog B, centractin beta...

(Previous names: ARP1 (actin-related protein 1, yeast) homolog B (centractin...)
(Previous symbol: CTRN2)
 Explore 4 diseases affiliated with
ACTR1B via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ACTR1B    

Aliases
for ACTR1B gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
ARP1 Actin-Related Protein 1 Homolog B, Centractin Beta (Yeast)1 2     ARP1 (Actin-Related Protein 1, Yeast) Homolog B (Centractin Beta)1
CTRN21 2 3 5     PC32
ARP1B2 3 5     Beta-Centractin1
Actin-Related Protein 1B2 3     Centractin Beta2

External Ids:    HGNC: 1681   Entrez Gene: 101202   Ensembl: ENSG000001150737   OMIM: 6051445   UniProtKB: P420253   

Export aliases for ACTR1B gene to outside databases

Previous GC identifers: GC02M096154 GC02M096724 GC02M097877 GC02M097893 GC02M097730 GC02M097638 GC02M092038


Summaries
for ACTR1B gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ACTR1B:
This gene encodes a 42.3 kD subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size
from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein and is involved in a diverse array of
cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle
formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like ACTR1A, is an actin-related
protein. These two proteins, which are of equal length and share 90% amino acid identity, are present in a constant
ratio of approximately 1:15 in the dynactin complex. (provided by RefSeq, Aug 2008)

UniProtKB/Swiss-Prot: ACTY_HUMAN, P42025
Function: Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with
the centrosome

Gene Wiki entry for ACTR1B


Genomic Views
for ACTR1B gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_022171.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ACTR1B gene promoter:
         Nkx3-1   AhR   GATA-3   Egr-1   Nkx3-1 v1   YY1   C/EBPalpha   Nkx3-1 v2   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ACTR1B promoter sequence
   Search SABiosciences Chromatin IP Primers for ACTR1B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ACTR1B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q11.1-q11.2   Ensembl cytogenetic band:  2q11.2   HGNC cytogenetic band: 2q11.1-q11.2

ACTR1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ACTR1B gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M098272:  view genomic region     (about GC identifiers)

Start:
 98,272,402 bp from pter      End:
 98,280,570 bp from pter
Size:
 8,169 bases      Orientation:
 minus strand

Proteins
for ACTR1B gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ACTY_HUMAN, P42025 (See protein sequence)
Recommended Name: Beta-centractin  
Size: 376 amino acids; 42293 Da
Subcellular location: Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, centrosome
Secondary accessions: D3DVH2 Q53SK5 Q9BRB7

Explore the universe of human proteins at neXtProt for ACTR1B: NX_P42025

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P42025

    • ACTR1B Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_005726.1  
    ENSEMBL proteins: 
     ENSP00000289228   ENSP00000408202  
    Reactome Protein details: P42025
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: ACTR1B
    OriGene Protein Over-expression Lysate: ACTR1B
    OriGene Custom Protein Services for ACTR1B 
    GenScript Custom Purified and Recombinant Proteins Services for ACTR1B
    Novus Biologicals ACTR1B Protein
    Novus Biologicals ACTR1B Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ACTR1B

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005813centrosome IDA--
    GO:0005829cytosol TAS--
    GO:0005869dynactin complex TAS7696711


    ACTR1B for ontologies           About GeneDecksing



    ACTR1B Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies (see all 2): ACTR1B
    OriGene Custom Antibody Services for ACTR1B 
    GenScript Custom Superior Antibodies Services for ACTR1B
    Novus Biologicals ACTR1B Antibodies
    Search for Antibodies for ACTR1B at Abcam  
    Uscn Antibodies for ACTR1B
    ThermoFisher Antibodies for ACTR1B

    Assay Products for ACTR1B: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ACTR1B
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for ACTR1B

    Protein Domains /
    Families
    for ACTR1B gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ACTR1B for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR004001 Actin_CS
     IPR004000 Actin-related
     IPR020902 Actin/actin-like_CS

    Graphical View of Domain Structure for InterPro Entry P42025

    ProtoNet protein and cluster: P42025

    1 Blocks protein family: IPB004000 Actin/actin-like

    UniProtKB/Swiss-Prot: ACTY_HUMAN, P42025
    Similarity: Belongs to the actin family. ARP1 subfamily


    Function
    for ACTR1B gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ACTY_HUMAN, P42025
    Function: Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with
    the centrosome

         Genatlas biochemistry entry for ACTR1B:
    centractin beta,an actin-related protein 1 yeast homolog,localized to microtubule-associated structures,widely
    expressed,component of the dynactin complex,a regulator of cytoplasmic dynein-mediated functions

    miRNA
    Products:            		 OriGene 3'-UTR Clone: ACTR1B
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ACTR1B
    8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate ACTR1B (see all 23):
    hsa-miR-302d hsa-miR-520e hsa-miR-520d-5p hsa-let-7a-2* hsa-miR-944 hsa-miR-302e hsa-miR-520a-3p hsa-miR-372
    SwitchGear 3'UTR luciferase reporter plasmid: ACTR1B 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ACTR1B (see all 7)
    OriGene shRNA RFP: ACTR1B
    OriGene siRNA: ACTR1B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ACTR1B

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ACTR1B

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ACTR1B (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ACTR1B (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: ACTR1B (NM_005735)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ACTR1B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACTR1B 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for ACTR1B
    Search LifeMap BioReagents cell lines for ACTR1B

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACTR1B

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12857853
    GO:0005524ATP binding IEA--


    ACTR1B for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for ACTR1B:
     Decreased POU5F1-GFP protein e 


    Pathways & Interactions
    for ACTR1B gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cytoskeleton remodeling Neurofilaments
    		Cytoskeleton remodeling Neurofilaments1.00
    		Cytoplasmic microtubules0.32
    		Cytoskeleton remodeling_Neurofilaments0.91
    2Cell cycle_Spindle assembly and chromosome separation
    		Cell cycle_Spindle assembly and chromosome separation1.00
    		Cell cycle Spindle assembly and chromosome separation0.94
    3Immune System
    		Immune System1.00
    		Adaptive Immune System0.59
    4MHC class II antigen presentation
    		MHC class II antigen presentation1.00
    		Transport of antigen loaded MHC II molecules to surface0.59

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    3 EMD Millipore Pathways for ACTR1B
        Cell cycle Spindle assembly and chromosome separation
    Cytoskeleton remodeling Neurofilaments
    Cytoplasmic microtubules


    2 GeneGo (Thomson Reuters) Pathways for ACTR1B
        Cell cycle Spindle assembly and chromosome separation
    Cytoskeleton remodeling Neurofilaments

    4        Reactome Pathways for ACTR1B
        Transport of antigen loaded MHC II molecules to surface
    Adaptive Immune System
    Immune System
    MHC class II antigen presentation



    ACTR1B for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ACTR1B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/27 Interacting proteins for ACTR1B (P420251, 2, 3 ENSP000002892284) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CHD3Q128732, 3MINT-63739 I2D: score=4 
    CSNK2BP678702, 3MINT-8252967 I2D: score=2 
    MAPK6Q166592, 3MINT-8260647 I2D: score=2 
    TK1P041832, 3MINT-8272850 I2D: score=2 
    DCTN1Q142033, ENSP000003547914I2D: score=2 STRING: ENSP00000354791
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class II TAS--


    ACTR1B for ontologies           About GeneDecksing



    Drugs & Compounds
    for ACTR1B gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ACTR1B
    Search CenterWatch for drugs/clinical trials and news about ACTR1B / ACTY 

    Transcripts
    for ACTR1B gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ACTR1B gene: 
    NM_005735.3  

    Unigene Cluster for ACTR1B:

    ARP1 actin-related protein 1 homolog B, centractin beta (yeast)
    Hs.98791  [show with all ESTs]
    Unigene Representative Sequence: NM_005735
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000289228(uc002syb.2) ENST00000451664 ENST00000460427

    miRNA
    Products:             		 OriGene 3'-UTR Clone: ACTR1B
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ACTR1B
    8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate ACTR1B (see all 23):
    hsa-miR-302d hsa-miR-520e hsa-miR-520d-5p hsa-let-7a-2* hsa-miR-944 hsa-miR-302e hsa-miR-520a-3p hsa-miR-372
    SwitchGear 3'UTR luciferase reporter plasmid: ACTR1B 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ACTR1B (see all 7)
    OriGene shRNA RFP: ACTR1B
    OriGene siRNA: ACTR1B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ACTR1B
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ACTR1B (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ACTR1B (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: ACTR1B (NM_005735)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ACTR1B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACTR1B 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ACTR1B
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ACTR1B
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ACTR1B
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ACTR1B

    Additional cDNA sequence: 

    BC004374.2 BC006372.2 BC010090.2 BC025274.2 X82207.1 X82208.1 

    7 DOTS entries:

    DT.455713  DT.100816788  DT.95340669  DT.95340663  DT.100832245  DT.95136240  DT.102828619 

    24/324 AceView cDNA sequences (see all 324):

    CA394896 AA445915 T35927 BM667493 BE746580 BF063185 BU860475 BQ063766 
    H10104 BM795370 BI857329 AA878962 BQ721956 AI867304 AI701808 BM826972 
    BU189223 BM824177 BU683973 BF724389 BX399664 AI918337 CR611704 BM848153 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ACTR1B    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12
    SP1:                          -     -                       -                                                   
    SP2:                    -     -     -                       -                                                   
    SP3:                          -     -                                                                           
    SP4:                                                                                                            
    SP5:                                                                                                            


    ECgene alternative splicing isoforms for ACTR1B

    Expression
    for ACTR1B gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ACTR1B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See ACTR1B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ACTR1B

    SOURCE GeneReport for Unigene cluster: Hs.98791
        SABiosciences Custom PCR Arrays for ACTR1B
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ACTR1B
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ACTR1B
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ACTR1B
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ACTR1B
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACTR1B

    Orthologs
    for ACTR1B gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ACTR1B gene from 6/29 species (see all 29)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves E1BXV2_CHICK6
    		 Uncharacterized protein
    		 45(a)
    		 possible ortholog
    		 21(1236427-1237560)
    lizard
    (Anolis carolinensis)    		 Reptilia ACTR1B6
    ACTRT36
    (see all 4)    		 --
    		 96(a)
    49(a)
    (see all 4)    		 1 ↔ 1
    possible ortholog
    (see all 4)    		 GL343484.1(127239-140768)
    3(8001296-8005919)
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.54682 Danio rerio mRNA similar to RIKEN cDNA 2310066K23 gene (cDNA clone MGC56317 IMAGE5603438), complete cds less 79.95(n)    BC046069.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Arp87C3 cytoskeleton organization and biogenesis
    structural constituent of cytoskeleton less    		 76(a)   87C5   --
    worm
    (Caenorhabditis elegans)    		 Secernentea Y53F4B.223 actin-like protein 67(a)   II(15115961-15118715)   --
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes ARP1(YHR129C)4
    ARP11    		 Actin-related protein of the dynactin complex; required for spindle orientation and nuclear migration; putative ortholog of mammalian centractin less4
    Arp1p1    		 55.28(n)1
    54.34(a)1    		   8(364153-362999)4
    8565301, 4  NP_011997.11, 4 


    ENSEMBL Gene Tree for ACTR1B (if available)
    TreeFam Gene Tree for ACTR1B (if available) 

    Paralogs
    for ACTR1B gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ACTR1B gene
    ACTG22  ACTA22  ACTB2  ACTRT22  ACTR1A2  ACTC12  ACTL92  ACTRT12  
    ACTG12  ACTL7A2  ACTBL22  ACTL7B2  ACTA12  ACTRT32  
    18/29 SIMAP similar genes for ACTR1B using alignment to 2 protein entries:     ACTY_HUMAN (see all proteins) (see all similar genes):
    ACTR1A    ACT    ACTA2    ACTBL2    ACTC1    ACTG1
    POTEKP    ACTB    PS1TP5BP1    ACTG2    POTEE    POTEF
    POTEI    POTEJ    ACTR2    ACTRT2    ACTRT3    ACTA1

    ACTR1B for paralogs           About GeneDecksing



    Genomic Variants
    for ACTR1B gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/167 NCBI SNPs in ACTR1B are shown (see all 167)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs745792401,2
    		--92041732(+) CCAGAA/CCCTCA 1 -- int10--------
    rs15509951,2
    		C,F,A,H,--98271946(+) TTAAGG/AAAGTA 1 -- ds500125Minor allele frequency- A:0.44NS EA NA WA CSA 2356
    rs769741721,2
    		--98271977(+) CCCTAA/GTTCCT 1 -- ds50010--------
    rs1482745461,2
    		--98271988(+) CACTGC/TTCTTC 1 -- ds50010--------
    rs1916936351,2
    		--98272121(+) GCTGAA/TTGGGG 1 -- ds50010--------
    rs67162081,2
    		C,--98272280(+) TGCCAC/TGTTGG 1 -- ds50012Minor allele frequency- T:0.10WA 120
    rs1835747041,2
    		--98272312(+) CATGCA/CGCTAA 1 -- ds50010--------
    rs799235931,2
    		--98272362(+) CTCTGA/CAAGTC 1 -- ds50010--------
    rs22901231,2
    		C,F,A,H,--98272491(+) GTTAAA/GTTATT 1 -- ut319Minor allele frequency- G:0.10EA NS NA WA 1954
    rs1881718991,2
    		--98272545(+) AGTGAC/TGACCT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ACTR1B (98272402 - 98280570 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for ACTR1B
         2 CNVs: 3378 2402

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ACTR1B
    DNA2.0 Custom Variant and Variant Library Synthesis for ACTR1B

    Disorders / Diseases
    for ACTR1B gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ACTR1B for disorders           About GeneDecksing

    OMIM gene information: 605144    OMIM disorders: --

    4 diseases for ACTR1B:    About MalaCards
    hepatocellular carcinoma    neuroblastoma    carcinoma    malaria


    Export disorders for ACTR1B gene to outside databases

    Publications
    for ACTR1B gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ACTR1B gene, integrated from 9 sources (see all 23):
    (articles sorted by number of sources associating them with ACTR1B)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Beta-centractin: characterization and distribution of a new member of the centractin family of actin-related proteins. (PubMed id 7696711)1, 2, 3, 9 Clark S.W.... Clark I.B. (1994)
    2. Assignment of beta-centractin (CTRN2) to human chromo some 2 bands q11.1-->q11.2 with somatic cell hybrids and in situ hybridizati on. (PubMed id 10343100)1, 3, 9 Elsea S.H....Patel P.I. (1999)
    3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Down-regulation of beta-centractin might be involved in dendritic cells dysfunction and subsequent hepatocellular carcinoma immune escape: a proteomic study. (PubMed id 17619203)1, 9 Weng Y.Q....Tang Z.Y. (2008)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    7. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    9. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    10. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)

    External Searches for ACTR1B gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ACTR1B gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10120 HGNC: 168 AceView: ACTR1B Ensembl:ENSG00000115073 euGenes: HUgn10120
    ECgene: ACTR1B H-InvDB: ACTR1B

    Other Databases showing ACTR1B gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ACTR1B gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ACTR1B Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ACTR1B gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ACTR1B gene:
    Search GeneIP for patents involving ACTR1B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for ACTR1B gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for ACTR1B   OriGene shRNA RFP for ACTR1B  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ACTR1B   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ACTR1B  
     OriGene Protein Over-expression Lysate for ACTR1B   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for ACTR1B   OriGene 3'-UTR Clone for ACTR1B  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ACTR1B   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ACTR1B  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for ACTR1B   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ACTR1B   OriGene Custom Protein Services for ACTR1B  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ACTR1B
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ACTR1B
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ACTR1B
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ACTR1B
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ACTR1B
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ACTR1B
     GenScript Custom Purified and Recombinant Proteins Services for ACTR1B GenScript cDNA clones with any tag delivered in your preferred vector for ACTR1B
     GenScript Custom Assay Services for ACTR1B GenScript Custom Superior Antibodies Services for ACTR1B
     GenScript Custom overexpressing Cell Line Services for ACTR1B CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in ACTR1B promoter
     Search Chromatin IP Primers for ACTR1B
     RT2 qPCR Primer Assay in human, mouse, rat ACTR1B
     GNC Network for ACTR1B
     SABiosciences Custom PCR Arrays for ACTR1B
     Search Tocris compounds for ACTR1B
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     ACTR1B antibodies
     ACTR1B proteins
     ACTR1B lysates
     Search for Antibodies for ACTR1B at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for ACTR1B
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     ACTR1B Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for ACTR1B
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACTR1B
     SwitchGear 3'UTR luciferase reporter plasmids for ACTR1B
     SwitchGear Promoter luciferase reporter plasmids for ACTR1B
     ThermoFisher Antibodies for ACTR1B
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACTR1B
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      ACTR1B gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4