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ACTR1B Gene

protein-coding   GIFtS: 63
GCID: GC02M098272

ARP1 Actin-Related Protein 1 Homolog B, Centractin Beta...

(Previous names: ARP1 (actin-related protein 1, yeast) homolog B (centractin...)
(Previous symbol: CTRN2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ARP1 Actin-Related Protein 1 Homolog B, Centractin Beta (Yeast)1 2     ARP1 (Actin-Related Protein 1, Yeast) Homolog B (Centractin Beta)1
CTRN21 2 3 5     PC32
ARP1B2 3 5     beta-centractin2
Actin-Related Protein 1B2 3     Centractin Beta2

External Ids:    HGNC: 1681   Entrez Gene: 101202   Ensembl: ENSG000001150737   OMIM: 6051445   UniProtKB: P420253   

Export aliases for ACTR1B gene to outside databases

Previous GC identifers: GC02M096154 GC02M096724 GC02M097877 GC02M097893 GC02M097730 GC02M097638 GC02M092038


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ACTR1B Gene:
This gene encodes a 42.3 kD subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in
size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein and is involved in a diverse
array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and
endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like
ACTR1A, is an actin-related protein. These two proteins, which are of equal length and share 90% amino acid
identity, are present in a constant ratio of approximately 1:15 in the dynactin complex. (provided by RefSeq, Aug
2008)

GeneCards Summary for ACTR1B Gene:
ACTR1B (ARP1 actin-related protein 1 homolog B, centractin beta (yeast)) is a protein-coding gene. Diseases associated with ACTR1B include neuroblastoma, and hepatocellular carcinoma. An important paralog of this gene is ACTG2.

UniProtKB/Swiss-Prot: ACTY_HUMAN, P42025
Function: Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated
with the centrosome

Gene Wiki entry for ACTR1B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ACTR1B gene promoter:
         Nkx3-1   AhR   GATA-3   Egr-1   Nkx3-1 v1   YY1   C/EBPalpha   Nkx3-1 v2   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidACTR1B promoter sequence
   Search Chromatin IP Primers for ACTR1B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ACTR1B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q11.1-q11.2   Ensembl cytogenetic band:  2q11.2   HGNC cytogenetic band: 2q11.1-q11.2

ACTR1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ACTR1B gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M098272:  view genomic region     (about GC identifiers)

Start:
98,272,402 bp from pter      End:
98,280,570 bp from pter
Size:
8,169 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ACTY_HUMAN, P42025 (See protein sequence)
Recommended Name: Beta-centractin  
Size: 376 amino acids; 42293 Da
Secondary accessions: D3DVH2 Q53SK5 Q9BRB7

Explore the universe of human proteins at neXtProt for ACTR1B: NX_P42025

Explore proteomics data for ACTR1B at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys32
  • Modification sites at PhosphoSitePlus

  • See ACTR1B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005726.1  
    ENSEMBL proteins: 
     ENSP00000289228  
    Reactome Protein details: P42025

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR020902 Actin/actin-like_CS
     IPR004001 Actin_CS
     IPR004000 Actin-related

    Graphical View of Domain Structure for InterPro Entry P42025

    ProtoNet protein and cluster: P42025

    1 Blocks protein domain: IPB004000 Actin/actin-like

    UniProtKB/Swiss-Prot: ACTY_HUMAN, P42025
    Similarity: Belongs to the actin family. ARP1 subfamily


    ACTR1B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ACTY_HUMAN, P42025
    Function: Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated
    with the centrosome

         Genatlas biochemistry entry for ACTR1B:
    centractin beta,an actin-related protein 1 yeast homolog,localized to microtubule-associated structures,widely
    expressed,component of the dynactin complex,a regulator of cytoplasmic dynein-mediated functions

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12857853
    GO:0005524ATP binding IEA--
         
    ACTR1B for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ACTR1B:
     Decreased POU5F1-GFP protein e 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ACTR1B
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    miRTarBase miRNAs that target ACTR1B:
    hsa-mir-100-5p (MIRT048557), hsa-mir-99b-5p (MIRT044201), hsa-mir-192-5p (MIRT026412)

    Block miRNA regulation of human, mouse, rat ACTR1B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ACTR1B (see all 23):
    hsa-miR-302d hsa-miR-520e hsa-miR-520d-5p hsa-let-7a-2* hsa-miR-944 hsa-miR-302e hsa-miR-520a-3p hsa-miR-372
    SwitchGear 3'UTR luciferase reporter plasmidACTR1B 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ACTY_HUMAN, P42025: Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol4
    nucleus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005813centrosome IDA--
    GO:0005829cytosol TAS--
    GO:0005869dynactin complex TAS7696711

    ACTR1B for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ACTR1B About    
    See pathways by source

    SuperPathContained pathways About
    1Cytoplasmic microtubules
    Cytoplasmic microtubules0.32
    Cytoskeleton remodeling Neurofilaments0.32
    2Class I MHC mediated antigen processing and presentation
    Adaptive Immune System0.41
    3MHC class II antigen presentation
    MHC class II antigen presentation
    4Cell cycle Spindle assembly and chromosome separation
    Cell cycle Spindle assembly and chromosome separation

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 GeneGo (Thomson Reuters) Pathways for ACTR1B
        Cell cycle Spindle assembly and chromosome separation
    Cytoskeleton remodeling Neurofilaments


    1 Reactome Pathway for ACTR1B
        MHC class II antigen presentation



    ACTR1B for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ACTR1B
    Interactions:

        GeneGlobe Interaction Network for ACTR1B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ACTR1B (P420251, 2, 3 ENSP000002892284) via UniProtKB, MINT, STRING, and/or I2D (see all 122)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CSNK2BP678702, 3MINT-8252967 I2D: score=2 
    ENSG00000206406P678702, 3MINT-8252967 I2D: score=2 
    ENSG00000224398P678702, 3MINT-8252967 I2D: score=2 
    ENSG00000224774P678702, 3MINT-8252967 I2D: score=2 
    ENSG00000228875P678702, 3MINT-8252967 I2D: score=2 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class II TAS--

    ACTR1B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ACTR1B (ACTY)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ACTR1B gene: 
    NM_005735.3  

    Unigene Cluster for ACTR1B:

    ARP1 actin-related protein 1 homolog B, centractin beta (yeast)
    Hs.98791  [show with all ESTs]
    Unigene Representative Sequence: NM_005735
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000289228(uc002syb.2) ENST00000451664 ENST00000460427
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ACTR1B (see all 23):
    hsa-miR-302d hsa-miR-520e hsa-miR-520d-5p hsa-let-7a-2* hsa-miR-944 hsa-miR-302e hsa-miR-520a-3p hsa-miR-372
    SwitchGear 3'UTR luciferase reporter plasmidACTR1B 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat ACTR1B
      QuantiFast Probe-based Assays in human, mouse, rat ACTR1B

    Additional mRNA sequence: 

    BC004374.2 BC006372.2 BC010090.2 BC025274.2 X82207.1 X82208.1 

    7 DOTS entries:

    DT.455713  DT.100816788  DT.95340669  DT.95340663  DT.100832245  DT.95136240  DT.102828619 

    Selected AceView cDNA sequences (see all 324):

    BX399664 BM795370 AI701808 BM848153 BU189223 AI918337 BQ721956 BQ063766 
    T35927 BF063185 AA445915 BF430999 BU860475 BU683973 BF724389 AA878962 
    BM667493 BE746580 AI867304 H10104 CA394896 BI857329 CR611704 BM824177 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ACTR1B    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12
    SP1:                          -     -                       -                                                   
    SP2:                    -     -     -                       -                                                   
    SP3:                          -     -                                                                           
    SP4:                                                                                                            
    SP5:                                                                                                            


    ECgene alternative splicing isoforms for ACTR1B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ACTR1B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ACTR1B Expression
    About this image

    ACTR1B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ACTR1B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.98791
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ACTR1B gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Actr1b1 , 5 ARP1 actin-related protein 1 homolog B, centractin more5
    ARP1 actin-related protein 1B, centractin beta1
    89.36(n)1
    98.94(a)1
      1 (15.38 cM)5
    2269771  NM_146107.21  NP_666219.11 
     366992025 
    lizard
    (Anolis carolinensis)
    Reptilia ACTR1B6
    ARP1 actin-related protein 1 homolog B, centractin...
    96(a)
    1 ↔ 1
    GL343484.1(127239-140768)
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.54682 Danio rerio mRNA similar to RIKEN cDNA 2310066K23 gene more 79.95(n)    BC046069.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Arp87C3 cytoskeleton organization and
    biogenesis structural more
    76(a)   87C5   --
    worm
    (Caenorhabditis elegans)
    Secernentea Y53F4B.223 actin-like protein 67(a)   II(15115961-15118715)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ARP1(YHR129C)4
    ARP11
    Actin-related protein of the dynactin complex; required more4
    ARP11
    55.31(n)1
    54.19(a)1
      8(364153-362999)4
    8565301, 4  NP_011997.11, 4 


    ENSEMBL Gene Tree for ACTR1B (if available)
    TreeFam Gene Tree for ACTR1B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ACTR1B gene
    ACTG22  ACTA22  ACTRT22  ACTR1A2  ACTB2  ACTC12  ACTRT12  ACTG12  
    ACTBL22  ACTA12  ACTRT32  
    Selected SIMAP similar genes for ACTR1B using alignment to 1 protein entry:     ACTY_HUMAN(see all similar genes):
    ACTR1A    ACTA2    ACTG1    ACTB    ACTBL2    ACTC1
    POTEKP    PS1TP5BP1    ACTG2    POTEE    POTEF    POTEI
    POTEJ    POTEM    ACTR2    ACTRT2    ACTRT3    ACTRT1

    ACTR1B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ACTR1B (see all 258)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs15509951,2
    C,F,A,H--98271946(+) TTAAGG/AAAGTA 1 -- ds500125Minor allele frequency- A:0.44NS EA NA WA CSA 2356
    rs769741721,2
    C--98271977(+) CCCTAA/GTTCCT 1 -- ds50010--------
    rs1482745461,2
    --98271988(+) CACTGC/TTCTTC 1 -- ds50010--------
    rs1916936351,2
    --98272121(+) GCTGAA/TTGGGG 1 -- ds50010--------
    rs67162081,2
    C--98272280(+) TGCCAC/TGTTGG 1 -- ds50012Minor allele frequency- T:0.10WA 120
    rs1835747041,2
    --98272312(+) CATGCA/CGCTAA 1 -- ds50010--------
    rs799235931,2
    C--98272362(+) CTCTGA/CAAGTC 1 -- ds50010--------
    rs22901231,2
    C,F,A,H--98272491(+) GTTAAA/GTTATT 1 -- ut319Minor allele frequency- G:0.10EA NS NA WA 1954
    rs1881718991,2
    --98272545(+) AGTGAC/TGACCT 1 -- ut310--------
    rs34751,2
    C,F--98272634(-) ATGCTC/TATCAT 1 -- ut317Minor allele frequency- T:0.13MN WA NA CSA 430

    HapMap Linkage Disequilibrium report for ACTR1B (98272402 - 98280570 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ACTR1B:    About this table    
    Variant IDTypeSubtypePubMed ID
    essv17999CNV CNV17122850
    esv718CNV CNV17122850
    essv18990CNV CNV17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605144    OMIM disorders: --

    2 diseases for ACTR1B:    
    About MalaCards
    neuroblastoma    hepatocellular carcinoma


    ACTR1B for disorders           About GeneDecksing

    Genetic Association Database (GAD): ACTR1B

    Export disorders for ACTR1B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ACTR1B gene, integrated from 10 sources (see all 25):
    (articles sorted by number of sources associating them with ACTR1B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Beta-centractin: characterization and distribution of a new member of the centractin family of actin-related proteins. (PubMed id 7696711)1, 2, 3, 9 Clark S.W.... Clark I.B. (Mol. Biol. Cell 1994)
    2. Assignment of beta-centractin (CTRN2) to human chromosome 2 bands q11.1--&gt;q11.2 with somatic cell hybrids and in situ hybridization. (PubMed id 10343100)1, 3, 9 Elsea S.H....Patel P.I. (Cytogenet. Cell Genet. 1999)
    3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Down-regulation of beta-centractin might be involved in dendritic cells dysfunction and subsequent hepatocellular carcinoma immune escape: a proteomic study. (PubMed id 17619203)1, 9 Weng Y.Q....Tang Z.Y. (J. Cancer Res. Clin. Oncol. 2008)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    7. Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-I+-acetylation features. (PubMed id 22223895)2 Bienvenut W.V....Giglione C. (amp 2012)
    8. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    10. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10120 HGNC: 168 AceView: ACTR1B Ensembl:ENSG00000115073 euGenes: HUgn10120
    ECgene: ACTR1B H-InvDB: ACTR1B

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ACTR1B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ACTR1B gene:
    Search GeneIP for patents involving ACTR1B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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