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Aliases for ACTR1B Gene

Aliases for ACTR1B Gene

  • ARP1 Actin-Related Protein 1 Homolog B, Centractin Beta (Yeast) 2 3
  • Actin-Related Protein 1B 3 4
  • CTRN2 3 4
  • ARP1B 3 4
  • ARP1 (Actin-Related Protein 1, Yeast) Homolog B (Centractin Beta) 2
  • Centractin Beta 3
  • PC3 3

External Ids for ACTR1B Gene

Previous HGNC Symbols for ACTR1B Gene

  • CTRN2

Previous GeneCards Identifiers for ACTR1B Gene

  • GC02M096154
  • GC02M096724
  • GC02M097877
  • GC02M097893
  • GC02M097730
  • GC02M098272
  • GC02M092038

Summaries for ACTR1B Gene

Entrez Gene Summary for ACTR1B Gene

  • This gene encodes a 42.3 kD subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein and is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like ACTR1A, is an actin-related protein. These two proteins, which are of equal length and share 90% amino acid identity, are present in a constant ratio of approximately 1:15 in the dynactin complex. [provided by RefSeq, Aug 2008]

GeneCards Summary for ACTR1B Gene

ACTR1B (ARP1 Actin-Related Protein 1 Homolog B, Centractin Beta (Yeast)) is a Protein Coding gene. Among its related pathways are Immune System and MHC class II antigen presentation. An important paralog of this gene is ACTB.

UniProtKB/Swiss-Prot for ACTR1B Gene

  • Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome

Gene Wiki entry for ACTR1B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACTR1B Gene

Genomics for ACTR1B Gene

Regulatory Elements for ACTR1B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ACTR1B Gene

Chromosome:
2
Start:
97,655,939 bp from pter
End:
97,664,107 bp from pter
Size:
8,169 bases
Orientation:
Minus strand

Genomic View for ACTR1B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ACTR1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACTR1B Gene

Proteins for ACTR1B Gene

  • Protein details for ACTR1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P42025-ACTY_HUMAN
    Recommended name:
    Beta-centractin
    Protein Accession:
    P42025
    Secondary Accessions:
    • D3DVH2
    • Q53SK5
    • Q9BRB7

    Protein attributes for ACTR1B Gene

    Size:
    376 amino acids
    Molecular mass:
    42293 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ACTR1B Gene

Proteomics data for ACTR1B Gene at MOPED

Post-translational modifications for ACTR1B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ACTR1B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ACTR1B Gene

Domains & Families for ACTR1B Gene

Protein Domains for ACTR1B Gene

Suggested Antigen Peptide Sequences for ACTR1B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P42025

UniProtKB/Swiss-Prot:

ACTY_HUMAN :
  • Belongs to the actin family. ARP1 subfamily.
Family:
  • Belongs to the actin family. ARP1 subfamily.
genes like me logo Genes that share domains with ACTR1B: view

No data available for Gene Families for ACTR1B Gene

Function for ACTR1B Gene

Molecular function for ACTR1B Gene

GENATLAS Biochemistry:
centractin beta,an actin-related protein 1 yeast homolog,localized to microtubule-associated structures,widely expressed,component of the dynactin complex,a regulator of cytoplasmic dynein-mediated functions
UniProtKB/Swiss-Prot Function:
Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome

Gene Ontology (GO) - Molecular Function for ACTR1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12857853
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with ACTR1B: view
genes like me logo Genes that share phenotypes with ACTR1B: view

miRNA for ACTR1B Gene

miRTarBase miRNAs that target ACTR1B

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ACTR1B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for ACTR1B Gene

Localization for ACTR1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACTR1B Gene

Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ACTR1B Gene COMPARTMENTS Subcellular localization image for ACTR1B gene
Compartment Confidence
cytoskeleton 5
extracellular 5
cytosol 4

Gene Ontology (GO) - Cellular Components for ACTR1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005813 centrosome IDA 21399614
GO:0005829 cytosol TAS --
GO:0005869 dynactin complex IEA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with ACTR1B: view

Pathways & Interactions for ACTR1B Gene

genes like me logo Genes that share pathways with ACTR1B: view

Pathways by source for ACTR1B Gene

Gene Ontology (GO) - Biological Process for ACTR1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS --
genes like me logo Genes that share ontologies with ACTR1B: view

No data available for SIGNOR curated interactions for ACTR1B Gene

Drugs & Compounds for ACTR1B Gene

No Compound Related Data Available

Transcripts for ACTR1B Gene

mRNA/cDNA for ACTR1B Gene

Unigene Clusters for ACTR1B Gene

ARP1 actin-related protein 1 homolog B, centractin beta (yeast):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ACTR1B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ACTR1B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12
SP1: - - -
SP2: - - - -
SP3: - -
SP4:
SP5:

Relevant External Links for ACTR1B Gene

GeneLoc Exon Structure for
ACTR1B
ECgene alternative splicing isoforms for
ACTR1B

Expression for ACTR1B Gene

mRNA expression in normal human tissues for ACTR1B Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ACTR1B Gene



SOURCE GeneReport for Unigene cluster for ACTR1B Gene Hs.98791

genes like me logo Genes that share expression patterns with ACTR1B: view

Protein tissue co-expression partners for ACTR1B Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ACTR1B Gene

Orthologs for ACTR1B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ACTR1B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ACTR1B 35
  • 90.96 (n)
  • 97.61 (a)
ACTR1B 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ACTR1B 35
  • 91.84 (n)
  • 98.67 (a)
ACTR1B 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Actr1b 35
  • 89.36 (n)
  • 98.94 (a)
Actr1b 16
Actr1b 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ACTR1B 35
  • 99.2 (n)
  • 99.73 (a)
ACTR1B 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Actr1b 35
  • 90.43 (n)
  • 98.94 (a)
oppossum
(Monodelphis domestica)
Mammalia ACTR1B 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ACTR1B 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ACTR1B 36
  • 96 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii actr1 35
  • 79.7 (n)
  • 93.62 (a)
Dr.5468 35
actr1 36
  • 94 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8351 35
fruit fly
(Drosophila melanogaster)
Insecta Arp87C 37
  • 76 (a)
Arp87C 36
  • 77 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y53F4B.22 37
  • 67 (a)
arp-1 36
  • 67 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR051W 35
  • 63.09 (n)
  • 58.13 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E22925g 35
  • 55.23 (n)
  • 54.42 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARP1 35
  • 55.31 (n)
  • 54.19 (a)
ARP1 38
bread mold
(Neurospora crassa)
Ascomycetes NCU04247 35
  • 64.45 (n)
  • 65.37 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes arp1 35
  • 54.22 (n)
  • 52.27 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9685 36
  • 68 (a)
OneToMany
Species with no ortholog for ACTR1B:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ACTR1B Gene

ENSEMBL:
Gene Tree for ACTR1B (if available)
TreeFam:
Gene Tree for ACTR1B (if available)

Paralogs for ACTR1B Gene

Paralogs for ACTR1B Gene

genes like me logo Genes that share paralogs with ACTR1B: view

Variants for ACTR1B Gene

Sequence variations from dbSNP and Humsavar for ACTR1B Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs111464527 -- 97,657,008(+) AGCCA(A/C/G)CCACC intron-variant
rs112150624 -- 97,662,224(+) GCTCA(A/T)CATCC intron-variant
rs112204313 -- 97,660,507(+) AAGAA(C/T)ACATG intron-variant
rs112904064 -- 97,663,937(+) AGGCA(C/G)CGGAT utr-variant-5-prime
rs113670297 -- 97,660,568(+) GGTGT(C/T)ACCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ACTR1B Gene

Variant ID Type Subtype PubMed ID
esv718 CNV CNV 17122850
essv18990 CNV CNV 17122850
essv17999 CNV CNV 17122850

Variation tolerance for ACTR1B Gene

Residual Variation Intolerance Score: 17.35% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.35; 81.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ACTR1B Gene

HapMap Linkage Disequilibrium report
ACTR1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACTR1B Gene

Disorders for ACTR1B Gene

Relevant External Links for ACTR1B

Genetic Association Database (GAD)
ACTR1B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ACTR1B
genes like me logo Genes that share disorders with ACTR1B: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ACTR1B Gene

Publications for ACTR1B Gene

  1. Assignment of beta-centractin (CTRN2) to human chromosome 2 bands q11.1-->q11.2 with somatic cell hybrids and in situ hybridization. (PMID: 10343100) Elsea S.H. … Patel P.I. (Cytogenet. Cell Genet. 1999) 2 23 67
  2. Beta-centractin: characterization and distribution of a new member of the centractin family of actin-related proteins. (PMID: 7696711) Clark S.W. … Clark I.B. (Mol. Biol. Cell 1994) 2 23 67
  3. Identification of novel downstream targets of platelet glycoprotein VI activation by differential proteome analysis: implications for thrombus formation. (PMID: 20107233) Schulz C. … Arnold G.J. (Blood 2010) 23 67
  4. Down-regulation of beta-centractin might be involved in dendritic cells dysfunction and subsequent hepatocellular carcinoma immune escape: a proteomic study. (PMID: 17619203) Weng Y.Q. … Tang Z.Y. (J. Cancer Res. Clin. Oncol. 2008) 23 67
  5. [Relation between changes of dendritic cell function and down-regulation of beta-centractin in hepatocellular carcinoma]. (PMID: 17925177) Weng Y.Q. … Fan J. (Zhonghua Yi Xue Za Zhi 2007) 23 67

Products for ACTR1B Gene

Sources for ACTR1B Gene

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