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Aliases for ACTR1B Gene

Aliases for ACTR1B Gene

  • ARP1 Actin-Related Protein 1 Homolog B, Centractin Beta (Yeast) 2 3
  • CTRN2 3 4 6
  • ARP1B 3 4 6
  • Actin-Related Protein 1B 3 4
  • ARP1 (Actin-Related Protein 1, Yeast) Homolog B (Centractin Beta) 2
  • Centractin Beta 3
  • Beta-Centractin 3
  • PC3 3

External Ids for ACTR1B Gene

Previous Symbols for ACTR1B Gene

  • CTRN2

Summaries for ACTR1B Gene

Entrez Gene Summary for ACTR1B Gene

  • This gene encodes a 42.3 kD subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein and is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like ACTR1A, is an actin-related protein. These two proteins, which are of equal length and share 90% amino acid identity, are present in a constant ratio of approximately 1:15 in the dynactin complex. [provided by RefSeq, Aug 2008]

GeneCards Summary for ACTR1B Gene

ACTR1B (ARP1 Actin-Related Protein 1 Homolog B, Centractin Beta (Yeast)) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and MHC class II antigen presentation. An important paralog of this gene is ACTB.

UniProtKB/Swiss-Prot for ACTR1B Gene

  • Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome

Gene Wiki entry for ACTR1B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACTR1B Gene

Genomics for ACTR1B Gene

Genomic Location for ACTR1B Gene

Start:
97,655,939 bp from pter
End:
97,664,107 bp from pter
Size:
8,169 bases
Orientation:
Minus strand

Genomic View for ACTR1B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ACTR1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACTR1B Gene

Regulatory Elements for ACTR1B Gene

Proteins for ACTR1B Gene

  • Protein details for ACTR1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P42025-ACTY_HUMAN
    Recommended name:
    Beta-centractin
    Protein Accession:
    P42025
    Secondary Accessions:
    • D3DVH2
    • Q53SK5
    • Q9BRB7

    Protein attributes for ACTR1B Gene

    Size:
    376 amino acids
    Molecular mass:
    42293 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ACTR1B Gene

Proteomics data for ACTR1B Gene at MOPED

Post-translational modifications for ACTR1B Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys32

Other Protein References for ACTR1B Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ACTR1B Gene

Domains for ACTR1B Gene

Protein Domains for ACTR1B Gene

UniProtKB/Swiss-Prot:

ACTY_HUMAN
Family:
  • Belongs to the actin family. ARP1 subfamily.:
    • P42025
genes like me logo Genes that share domains with ACTR1B: view

No data available for Gene Families for ACTR1B Gene

Function for ACTR1B Gene

Molecular function for ACTR1B Gene

GENATLAS Biochemistry: centractin beta,an actin-related protein 1 yeast homolog,localized to microtubule-associated structures,widely expressed,component of the dynactin complex,a regulator of cytoplasmic dynein-mediated functions
UniProtKB/Swiss-Prot Function: Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome

Gene Ontology (GO) - Molecular Function for ACTR1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12857853
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with ACTR1B: view

Phenotypes for ACTR1B Gene

GenomeRNAi human phenotypes for ACTR1B:
genes like me logo Genes that share phenotypes with ACTR1B: view

miRNA for ACTR1B Gene

miRTarBase miRNAs that target ACTR1B

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ACTR1B Gene

Localization for ACTR1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACTR1B Gene

Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ACTR1B Gene COMPARTMENTS Subcellular localization image for ACTR1B gene
Compartment Confidence
cytoskeleton 5
cytosol 4
nucleus 1

Gene Ontology (GO) - Cellular Components for ACTR1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005813 centrosome IDA 21399614
GO:0005829 cytosol TAS --
GO:0005869 dynactin complex IEA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with ACTR1B: view

Pathways for ACTR1B Gene

genes like me logo Genes that share pathways with ACTR1B: view

Pathways by source for ACTR1B Gene

2 GeneGo (Thomson Reuters Life Sciences Research) pathways for ACTR1B Gene
2 Reactome pathways for ACTR1B Gene

Gene Ontology (GO) - Biological Process for ACTR1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS --
genes like me logo Genes that share ontologies with ACTR1B: view

Transcripts for ACTR1B Gene

mRNA/cDNA for ACTR1B Gene

Unigene Clusters for ACTR1B Gene

ARP1 actin-related protein 1 homolog B, centractin beta (yeast):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ACTR1B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12
SP1: - - -
SP2: - - - -
SP3: - -
SP4:
SP5:

Relevant External Links for ACTR1B Gene

GeneLoc Exon Structure for
ACTR1B
ECgene alternative splicing isoforms for
ACTR1B

Expression for ACTR1B Gene

mRNA expression in normal human tissues for ACTR1B Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ACTR1B Gene

SOURCE GeneReport for Unigene cluster for ACTR1B Gene Hs.98791

genes like me logo Genes that share expressions with ACTR1B: view

Orthologs for ACTR1B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ACTR1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ACTR1B 36
  • 99.2 (n)
  • 99.73 (a)
ACTR1B 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ACTR1B 36
  • 90.96 (n)
  • 97.61 (a)
ACTR1B 37
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ACTR1B 36
  • 91.84 (n)
  • 98.67 (a)
ACTR1B 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Actr1b 36
  • 89.36 (n)
  • 98.94 (a)
Actr1b 16
Actr1b 37
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ACTR1B 37
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ACTR1B 37
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Actr1b 36
  • 90.43 (n)
  • 98.94 (a)
lizard
(Anolis carolinensis)
Reptilia ACTR1B 37
  • 96 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8351 36
zebrafish
(Danio rerio)
Actinopterygii actr1 36
  • 79.7 (n)
  • 93.62 (a)
actr1 37
  • 94 (a)
OneToOne
Dr.5468 36
fruit fly
(Drosophila melanogaster)
Insecta Arp87C 37
  • 77 (a)
OneToMany
Arp87C 38
  • 76 (a)
worm
(Caenorhabditis elegans)
Secernentea arp-1 37
  • 67 (a)
OneToMany
Y53F4B.22 38
  • 67 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR051W 36
  • 63.09 (n)
  • 58.13 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARP1 36
  • 55.31 (n)
  • 54.19 (a)
ARP1 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E22925g 36
  • 55.23 (n)
  • 54.42 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU04247 36
  • 64.45 (n)
  • 65.37 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes arp1 36
  • 54.22 (n)
  • 52.27 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9685 37
  • 68 (a)
OneToMany
Species with no ortholog for ACTR1B:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ACTR1B Gene

ENSEMBL:
Gene Tree for ACTR1B (if available)
TreeFam:
Gene Tree for ACTR1B (if available)

Paralogs for ACTR1B Gene

Paralogs for ACTR1B Gene

genes like me logo Genes that share paralogs with ACTR1B: view

Variants for ACTR1B Gene

Sequence variations from dbSNP and Humsavar for ACTR1B Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs3474 -- 97,656,271(-) GAGGA(C/T)GCACG utr-variant-3-prime
rs3475 -- 97,656,171(-) ATGCT(C/T)ATCAT utr-variant-3-prime
rs13452 -- 97,656,399(-) CAGCC(A/C)CTTTC utr-variant-3-prime
rs873886 -- 97,661,341(+) GGTGC(C/T)CCTAA intron-variant
rs1042705 -- 97,658,064(-) CTTGT(C/G)GGGGA reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for ACTR1B Gene

Variant ID Type Subtype PubMed ID
esv718 CNV CNV 17122850
essv18990 CNV CNV 17122850
essv17999 CNV CNV 17122850

Relevant External Links for ACTR1B Gene

HapMap Linkage Disequilibrium report
ACTR1B

Disorders for ACTR1B Gene

Relevant External Links for ACTR1B

Genetic Association Database (GAD)
ACTR1B
genes like me logo Genes that share disorders with ACTR1B: view

No data available for UniProtKB/Swiss-Prot for ACTR1B Gene

Publications for ACTR1B Gene

  1. Beta-centractin: characterization and distribution of a new member of the centractin family of actin-related proteins. (PMID: 7696711) Clark S.W. … Clark I.B. (Mol. Biol. Cell 1994) 2 3 4 23
  2. Assignment of beta-centractin (CTRN2) to human chromosome 2 bands q11.1-->q11.2 with somatic cell hybrids and in situ hybridization. (PMID: 10343100) Elsea S.H. … Patel P.I. (Cytogenet. Cell Genet. 1999) 2 3 23
  3. Down-regulation of beta-centractin might be involved in dendritic cells dysfunction and subsequent hepatocellular carcinoma immune escape: a proteomic study. (PMID: 17619203) Weng Y.Q. … Tang Z.Y. (J. Cancer Res. Clin. Oncol. 2008) 3 23
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4

Products for ACTR1B Gene

Sources for ACTR1B Gene

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