ACTR1B Gene
protein-coding GIFtS: 60
GCID: GC02M098272
|
|
ARP1 actin-related protein 1 homolog B, centractin beta...(Previous names: ARP1 (actin-related protein 1, yeast) homolog B (centractin...)
(Previous symbol: CTRN2)
| |
Aliases
for ACTR1B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| ARP1 Actin-Related Protein 1 Homolog B, Centractin Beta (Yeast)1 2 | | ARP1 (Actin-Related Protein 1, Yeast) Homolog B (Centractin Beta)1 | | CTRN21 2 3 5 | | PC32 | | ARP1B2 3 5 | | Beta-Centractin1 | | Actin-Related Protein 1B2 3 | | Centractin Beta2 |
Export aliases for ACTR1B gene to outside databasesPrevious GC identifers: GC02M096154 GC02M096724 GC02M097877 GC02M097893 GC02M097730 GC02M097638 GC02M092038 |
Summaries
for ACTR1B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ACTR1B:
This gene encodes a 42.3 kD subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in sizefrom 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein and is involved in a diverse array ofcellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindleformation, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like ACTR1A, is an actin-relatedprotein. These two proteins, which are of equal length and share 90% amino acid identity, are present in a constantratio of approximately 1:15 in the dynactin complex. (provided by RefSeq, Aug 2008)
UniProtKB/Swiss-Prot: ACTY_HUMAN, P42025Function: Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated withthe centrosome
Gene Wiki entry for ACTR1B
|
Genomic Views
for ACTR1B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022171.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ACTR1B gene promoter:
Nkx3-1 AhR GATA-3 Egr-1 Nkx3-1 v1 YY1 C/EBPalpha Nkx3-1 v2 Nkx3-1 v3
Other transcription factors
Search SABiosciences Chromatin IP Primers for ACTR1B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ACTR1B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q11.1-q11.2 Ensembl cytogenetic band: 2q11.2 HGNC cytogenetic band: 2q11.1-q11.2ACTR1B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M098272: view genomic region
(about GC identifiers)
Start:
|
98,272,402 bp from pter |
End:
|
98,280,570 bp from pter |
Size:
|
8,169 bases |
Orientation:
|
minus strand |
|
Proteins
for ACTR1B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ACTY_HUMAN, P42025 (See
protein sequence)Recommended Name: Beta-centractin Size: 376 amino acids; 42293 Da
Subcellular location: Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, centrosome
Secondary accessions: D3DVH2 Q53SK5 Q9BRB7Explore the universe of human proteins at neXtProt for ACTR1B: NX_P42025
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P42025
ACTR1B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_005726.1
ENSEMBL proteins: ENSP00000289228 ENSP00000408202 Reactome Protein details: P42025
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
ACTR1B for ontologies About GeneDecksing
ACTR1B Antibody Products:
Assay Products for ACTR1B: |
Protein
Domains /
Families
for ACTR1B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ACTR1B for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P42025ProtoNet protein and cluster: P42025 1 Blocks protein family: IPB004000 Actin/actin-like
UniProtKB/Swiss-Prot: ACTY_HUMAN, P42025Similarity: Belongs to the actin family. ARP1 subfamily |
Function
for ACTR1B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ACTY_HUMAN, P42025Function: Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated withthe centrosome Genatlas biochemistry entry for ACTR1B:centractin beta,an actin-related protein 1 yeast homolog,localized to microtubule-associated structures,widelyexpressed,component of the dynactin complex,a regulator of cytoplasmic dynein-mediated functions
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ACTR1B (see all 2)
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACTR1B |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
ACTR1B for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for ACTR1B:
|
Pathways & Interactions
for ACTR1B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Cytoskeleton remodeling Neurofilaments | | | 2 | Cell cycle_Spindle assembly and chromosome separation | | | 3 | Immune System | | | 4 | MHC class II antigen presentation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
3 EMD Millipore Pathways for ACTR1B
2  GeneGo (Thomson Reuters) Pathways for ACTR1B
4 
Reactome Pathways for ACTR1B
ACTR1B for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ACTR1B
STRING Interaction
Network Preview (showing 5 interactants - click image to see 10)
5/27 Interacting proteins for ACTR1B (P420251, 2, 3 ENSP000002892284) via UniProtKB, MINT, STRING, and/or I2D (see all 27)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0019886 | antigen processing and presentation of exogenous peptide antigen via MHC class II |
TAS | -- |
ACTR1B for ontologies About GeneDecksing
|
Drugs & Compounds
for ACTR1B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ACTR1B
Search CenterWatch for drugs/clinical trials and news about ACTR1B / ACTY
|
Transcripts
for ACTR1B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ACTR1B gene: NM_005735.3 Unigene Cluster for ACTR1B: ARP1 actin-related protein 1 homolog B, centractin beta (yeast) Hs.98791 [show with all ESTs]Unigene Representative Sequence: NM_0057353 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000289228(uc002syb.2) ENST00000451664 ENST00000460427
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ACTR1B (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ACTR1B (NM_005735) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ACTR1B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACTR1B |
Additional cDNA sequence: BC004374.2 BC006372.2 BC010090.2 BC025274.2 X82207.1 X82208.1 7 DOTS entries: DT.455713 DT.100816788 DT.95340669 DT.95340663 DT.100832245 DT.95136240 DT.102828619 24/324 AceView cDNA sequences (see all 324): CA394896 AA445915 T35927 BM667493 BE746580 BF063185 BU860475 BQ063766 H10104 BM795370 BI857329 AA878962 BQ721956 AI867304 AI701808 BM826972 BU189223 BM824177 BU683973 BF724389 BX399664 AI918337 CR611704 BM848153
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for ACTR1B About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 |
|---|
|
| SP1: | | | | | | | | | - | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | - | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ACTR1B
|
Expression
for ACTR1B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ACTR1B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See ACTR1B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ACTR1B
SOURCE GeneReport for Unigene cluster: Hs.98791
SABiosciences Custom PCR Arrays for ACTR1B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ACTR1B
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACTR1B |
Orthologs
for ACTR1B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals and fungi.
Orthologs for ACTR1B gene from 6/29 species (see all 29) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
E1BXV2_CHICK6 |
Uncharacterized protein |
45(a) |
possible ortholog |
21(1236427-1237560) |
lizard
(Anolis carolinensis) |
Reptilia |
ACTR1B6ACTRT36(see all 4) |
-- |
96(a)49(a)(see all 4) |
1 ↔ 1possible ortholog(see all 4) |
GL343484.1(127239-140768) 3(8001296-8005919) |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.54682 |
Danio rerio mRNA similar to RIKEN cDNA 2310066K23 gene more |
79.95(n) |
|
BC046069.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Arp87C3 |
cytoskeleton organization and biogenesis
structural more |
76(a) |
|
87C5 -- |
worm
(Caenorhabditis elegans) |
Secernentea |
Y53F4B.223 |
actin-like protein |
67(a) |
|
II(15115961-15118715) -- |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
ARP1(YHR129C)4
ARP11 |
Actin-related protein of the dynactin complex; required more4
Arp1p1 |
55.28(n)1
54.34(a)1 |
|
8(364153-362999)4
8565301, 4 NP_011997.11, 4 |
ENSEMBL Gene Tree for ACTR1B (if available)
TreeFam Gene Tree for ACTR1B (if available) |
Paralogs
for ACTR1B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ACTR1B gene
- ACTG22 ACTA22 ACTB2 ACTRT22 ACTR1A2 ACTC12 ACTL92 ACTRT12
- ACTG12 ACTL7A2 ACTBL22 ACTL7B2 ACTA12 ACTRT32
18/29 SIMAP similar genes for ACTR1B using alignment to 2 protein entries: ACTY_HUMAN (see all proteins)
(see all similar genes):ACTR1A ACT ACTA2 ACTBL2 ACTC1 ACTG1
POTEKP ACTB PS1TP5BP1 ACTG2 POTEE POTEF
POTEI POTEJ ACTR2 ACTRT2 ACTRT3 ACTA1
ACTR1B for paralogs About GeneDecksing
|
Genomic Variants
for ACTR1B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ACTR1B (98272402 - 98280570 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for ACTR1B
2 CNVs: 3378 2402 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ACTR1B |
|
Disorders
/ Diseases
for ACTR1B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ACTR1B for disorders About GeneDecksing
OMIM gene information: 605144
OMIM disorders: --
4  diseases for ACTR1B: About MalaCardshepatocellular carcinoma neuroblastoma carcinoma malaria
Export disorders for ACTR1B gene to outside databases
|
Publications
for ACTR1B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ACTR1B gene, integrated from 9 sources (see all 23):
(articles sorted by number of sources associating them with ACTR1B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Beta-centractin: characterization and distribution of a new member of the centractin family of actin-related proteins. (PubMed id 7696711)1, 2, 3, 9 Clark S.W.... Clark I.B. (1994)
- Assignment of beta-centractin (CTRN2) to human chromo some 2 bands q11.1-->q11.2 with somatic cell hybrids and in situ hybridizati on. (PubMed id 10343100)1, 3, 9 Elsea S.H....Patel P.I. (1999)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Down-regulation of beta-centractin might be involved in dendritic cells dysfunction and subsequent hepatocellular carcinoma immune escape: a proteomic study. (PubMed id 17619203)1, 9 Weng Y.Q....Tang Z.Y. (2008)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
|
External Searches for ACTR1B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ACTR1B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ACTR1B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ACTR1B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ACTR1B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ACTR1B gene:
Search GeneIP for patents involving ACTR1B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ACTR1B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACTR1B |
|  |  |  | | | | ThermoFisher Antibodies for ACTR1B |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACTR1B |
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