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Aliases for ACTR1A Gene

Aliases for ACTR1A Gene

  • ARP1 Actin-Related Protein 1 Homolog A, Centractin Alpha 2 3 5
  • Centrosome-Associated Actin Homolog 3 4
  • Centractin 3 4
  • Actin-RPV 3 4
  • CTRN1 3 4
  • ARP1 3 4
  • ARP1 (Actin-Related Protein 1, Yeast) Homolog A (Centractin Alpha) 2
  • Alpha-Centractin 3
  • Arp1A 3

External Ids for ACTR1A Gene

Previous GeneCards Identifiers for ACTR1A Gene

  • GC10M103132
  • GC10M103472
  • GC10M104370
  • GC10M103903
  • GC10M104228
  • GC10M097872

Summaries for ACTR1A Gene

Entrez Gene Summary for ACTR1A Gene

  • This gene encodes a 42.6 kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 8-13 copies per dynactin molecule, and is the most abundant molecule in the dynactin complex. It is an actin-related protein, and is approximately 60% identical at the amino acid level to conventional actin. [provided by RefSeq, Jul 2008]

GeneCards Summary for ACTR1A Gene

ACTR1A (ARP1 Actin-Related Protein 1 Homolog A, Centractin Alpha) is a Protein Coding gene. Among its related pathways are Immune System and Regulation of PLK1 Activity at G2/M Transition. An important paralog of this gene is ACTR1B.

UniProtKB/Swiss-Prot for ACTR1A Gene

  • Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome.

Gene Wiki entry for ACTR1A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACTR1A Gene

Genomics for ACTR1A Gene

Regulatory Elements for ACTR1A Gene

Enhancers for ACTR1A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10F102595 1.6 FANTOM5 Ensembl ENCODE 12.8 -97.9 -97916 11.2 MLX ARID4B DMAP1 ZNF2 YY1 ZNF143 FOS SP5 MXD4 REST MFSD13A SFXN2 ACTR1A SUFU C10orf95 PSD FBXL15 CUEDC2 MIR146B ARL3
GH10F102578 1.3 Ensembl ENCODE 11.4 -77.5 -77546 3.4 HDGF PKNOX1 ARNT SIN3A FEZF1 YY1 ZNF766 ZNF143 FOS ZNF263 MFSD13A ACTR1A SUFU C10orf95 NFKB2 POLL AS3MT RPL23AP58 GC10P102592
GH10F102625 1.6 FANTOM5 Ensembl ENCODE 5.3 -128.1 -128146 11.8 ATF1 ZFP64 ARID4B YY1 GLIS2 FOS NFYC REST MIER3 GLIS1 MFSD13A SFXN2 ACTR1A CUEDC2 GBF1 TRIM8 RNU6-43P
GH10F102522 0.6 ENCODE 11.5 -20.7 -20723 1.4 ZSCAN16 RCOR2 ZMYM3 KDM1A NR2F6 ZNF623 NR2F2 MFSD13A SUFU ACTR1A RNU6-43P C10orf95 ELOVL3 GC10P102525 GC10M102448
GH10F102542 0.6 ENCODE 5 -40.2 -40218 1.1 ZNF263 ATF1 ZNF157 FOS SMAD4 MAFK ATF2 MFSD13A ARL3 ACTR1A GC10P102525 RPL23AP58
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ACTR1A on UCSC Golden Path with GeneCards custom track

Genomic Location for ACTR1A Gene

Chromosome:
10
Start:
102,461,881 bp from pter
End:
102,502,755 bp from pter
Size:
40,875 bases
Orientation:
Minus strand

Genomic View for ACTR1A Gene

Genes around ACTR1A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACTR1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACTR1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACTR1A Gene

Proteins for ACTR1A Gene

  • Protein details for ACTR1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61163-ACTZ_HUMAN
    Recommended name:
    Alpha-centractin
    Protein Accession:
    P61163
    Secondary Accessions:
    • B2R6B0
    • P42024

    Protein attributes for ACTR1A Gene

    Size:
    376 amino acids
    Molecular mass:
    42614 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ACTR1A Gene

Post-translational modifications for ACTR1A Gene

  • Ubiquitination at Lys 96, Lys 200, and Lys 308
  • Modification sites at PhosphoSitePlus

Other Protein References for ACTR1A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ACTR1A Gene

Domains & Families for ACTR1A Gene

Protein Domains for ACTR1A Gene

Suggested Antigen Peptide Sequences for ACTR1A Gene

Graphical View of Domain Structure for InterPro Entry

P61163

UniProtKB/Swiss-Prot:

ACTZ_HUMAN :
  • Belongs to the actin family. ARP1 subfamily.
Family:
  • Belongs to the actin family. ARP1 subfamily.
genes like me logo Genes that share domains with ACTR1A: view

No data available for Gene Families for ACTR1A Gene

Function for ACTR1A Gene

Molecular function for ACTR1A Gene

UniProtKB/Swiss-Prot Function:
Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome.

Gene Ontology (GO) - Molecular Function for ACTR1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with ACTR1A: view

Phenotypes for ACTR1A Gene

genes like me logo Genes that share phenotypes with ACTR1A: view

Animal Model Products

miRNA for ACTR1A Gene

miRTarBase miRNAs that target ACTR1A

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ACTR1A Gene

Localization for ACTR1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACTR1A Gene

Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ACTR1A gene
Compartment Confidence
extracellular 5
cytoskeleton 5
cytosol 5
golgi apparatus 2
nucleus 1

Gene Ontology (GO) - Cellular Components for ACTR1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002177 manchette IEA --
GO:0005737 cytoplasm IDA --
GO:0005813 centrosome IDA 21399614
GO:0005814 centriole IEA --
GO:0005815 microtubule organizing center IEA --
genes like me logo Genes that share ontologies with ACTR1A: view

Pathways & Interactions for ACTR1A Gene

genes like me logo Genes that share pathways with ACTR1A: view

Gene Ontology (GO) - Biological Process for ACTR1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0007283 spermatogenesis IEA --
GO:0016192 vesicle-mediated transport TAS 1528266
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS --
genes like me logo Genes that share ontologies with ACTR1A: view

No data available for SIGNOR curated interactions for ACTR1A Gene

Drugs & Compounds for ACTR1A Gene

(1) Drugs for ACTR1A Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for ACTR1A Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ACTR1A: view

Transcripts for ACTR1A Gene

Unigene Clusters for ACTR1A Gene

ARP1 actin-related protein 1 homolog A, centractin alpha (yeast):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ACTR1A Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b
SP1: - - -
SP2: - - - - -
SP3: - - -
SP4: - - - -
SP5:
SP6:
SP7:

Relevant External Links for ACTR1A Gene

GeneLoc Exon Structure for
ACTR1A
ECgene alternative splicing isoforms for
ACTR1A

Expression for ACTR1A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ACTR1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ACTR1A Gene

This gene is overexpressed in Fetal Brain (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ACTR1A Gene



Protein tissue co-expression partners for ACTR1A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ACTR1A Gene:

ACTR1A

SOURCE GeneReport for Unigene cluster for ACTR1A Gene:

Hs.153961
genes like me logo Genes that share expression patterns with ACTR1A: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ACTR1A Gene

Orthologs for ACTR1A Gene

This gene was present in the common ancestor of animals.

Orthologs for ACTR1A Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia ACTR1A 35
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ACTR1A 34 35
  • 99.65 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ACTR1A 35
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ACTR1A 34 35
  • 92.82 (n)
cow
(Bos Taurus)
Mammalia ACTR1A 34 35
  • 91.93 (n)
rat
(Rattus norvegicus)
Mammalia Actr1a 34
  • 91.49 (n)
mouse
(Mus musculus)
Mammalia Actr1a 34 16 35
  • 91.4 (n)
chicken
(Gallus gallus)
Aves ACTR1A 34 35
  • 83.24 (n)
lizard
(Anolis carolinensis)
Reptilia ACTR1A 35
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia actr1a 34
  • 79.61 (n)
Str.11859 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.11469 34
zebrafish
(Danio rerio)
Actinopterygii si:ch211-241j12.3 35
  • 10 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Arp87C 36 35
  • 78 (a)
Arp1 34
  • 71.01 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002127 34
  • 70.57 (n)
worm
(Caenorhabditis elegans)
Secernentea Y53F4B.22 36
  • 69 (a)
arp-1 34 35
  • 62.9 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9685 35
  • 69 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4114 34
Species where no ortholog for ACTR1A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ACTR1A Gene

ENSEMBL:
Gene Tree for ACTR1A (if available)
TreeFam:
Gene Tree for ACTR1A (if available)

Paralogs for ACTR1A Gene

Paralogs for ACTR1A Gene

Pseudogenes.org Pseudogenes for ACTR1A Gene

genes like me logo Genes that share paralogs with ACTR1A: view

Variants for ACTR1A Gene

Sequence variations from dbSNP and Humsavar for ACTR1A Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs28942088 Pathogenic 102,504,196(-) CCGGG(A/G)GCGCG intron-variant, upstream-variant-2KB, reference, missense
rs587776579 Pathogenic 102,504,223(+) CCCCC(-/C)GGCCT intron-variant, upstream-variant-2KB, reference, frameshift-variant
rs863224925 Pathogenic 102,504,263(-) CCGTA(-/G)ATGGC intron-variant, upstream-variant-2KB, reference, frameshift-variant
rs189234140 Likely benign 102,504,164(+) GAGCT(A/G)CGGCC intron-variant, upstream-variant-2KB, reference, synonymous-codon
rs746555296 Likely benign 102,504,158(+) ATGGC(G/T)GAGCT intron-variant, upstream-variant-2KB, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for ACTR1A Gene

Variant ID Type Subtype PubMed ID
nsv467445 CNV loss 19166990
nsv552059 CNV loss 21841781
nsv831968 CNV gain 17160897

Variation tolerance for ACTR1A Gene

Residual Variation Intolerance Score: 21.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.32; 7.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ACTR1A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ACTR1A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACTR1A Gene

Disorders for ACTR1A Gene

Relevant External Links for ACTR1A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ACTR1A

No disorders were found for ACTR1A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ACTR1A Gene

Publications for ACTR1A Gene

  1. A vertebrate actin-related protein is a component of a multisubunit complex involved in microtubule-based vesicle motility. (PMID: 1528266) Lees-Miller J.P. … Schroer T.A. (Nature 1992) 2 3 4 22 64
  2. Beta-centractin: characterization and distribution of a new member of the centractin family of actin-related proteins. (PMID: 7696711) Clark S.W. … Clark I.B. (Mol. Biol. Cell 1994) 3 4 22 64
  3. Regulation of microtubule dynamics by inhibition of the tubulin deacetylase HDAC6. (PMID: 19737819) Zilberman Y. … Bershadsky A. (J. Cell. Sci. 2009) 3 22 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4 64

Products for ACTR1A Gene

Sources for ACTR1A Gene

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