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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ACTR1A Gene

protein-coding   GIFtS: 57
GCID: GC10M104228

ARP1 actin-related protein 1 homolog A, centractin alpha...

(Previous names: ARP1 (actin-related protein 1, yeast) homolog A (centractin...)
 Explore 6 diseases affiliated with
ACTR1A via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ACTR1A    

Aliases
for ACTR1A gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
ARP1 Actin-Related Protein 1 Homolog A, Centractin Alpha (Yeast)1 2     Actin-RPV3
ARP11 2 3     Alpha-Centractin1
Centrosome-Associated Actin Homolog2 3     Centractin3
CTRN12 3     Actin-RPV3
ARP1 (Actin-Related Protein 1, Yeast) Homolog A (Centractin Alpha)1     Centractin3

External Ids:    HGNC: 1671   Entrez Gene: 101212   Ensembl: ENSG000001381077   OMIM: 6051435   UniProtKB: P611633   

Export aliases for ACTR1A gene to outside databases

Previous GC identifers: GC10M103132 GC10M103472 GC10M104370 GC10M103903 GC10M097872


Summaries
for ACTR1A gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ACTR1A:
This gene encodes a 42.6 kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size
from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of
cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle
formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 8-13 copies per
dynactin molecule, and is the most abundant molecule in the dynactin complex. It is an actin-related protein, and is
approximately 60% identical at the amino acid level to conventional actin. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ACTZ_HUMAN, P61163
Function: Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with
the centrosome

Gene Wiki entry for ACTR1A


Genomic Views
for ACTR1A gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ACTR1A gene promoter:
         AhR   NF-1   SREBP-1c   FOXD1   LCR-F1   YY1   SREBP-1b   AREB6   Egr-2   SREBP-1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ACTR1A promoter sequence
   Search SABiosciences Chromatin IP Primers for ACTR1A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ACTR1A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24.32   Ensembl cytogenetic band:  10q24.32   HGNC cytogenetic band: 10q24

ACTR1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ACTR1A gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M104228:  view genomic region     (about GC identifiers)

Start:
 104,238,986 bp from pter      End:
 104,262,512 bp from pter
Size:
 23,527 bases      Orientation:
 minus strand

Proteins
for ACTR1A gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ACTZ_HUMAN, P61163 (See protein sequence)
Recommended Name: Alpha-centractin  
Size: 376 amino acids; 42614 Da
Subcellular location: Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, centrosome
Secondary accessions: B2R6B0 P42024

Explore the universe of human proteins at neXtProt for ACTR1A: NX_P61163

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P61163

    • ACTR1A Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_005727.1  
    ENSEMBL proteins: 
     ENSP00000358921   ENSP00000406028   ENSP00000438890  
    Reactome Protein details: P61163
    Human Recombinant Protein Products: 
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    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005813centrosome IDA--
    GO:0005829cytosol TAS--
    GO:0005856cytoskeleton ----
    GO:0005869dynactin complex TAS7696711


    ACTR1A for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for ACTR1A gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ACTR1A for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR004001 Actin_CS
     IPR004000 Actin-related
     IPR020902 Actin/actin-like_CS

    Graphical View of Domain Structure for InterPro Entry P61163

    ProtoNet protein and cluster: P61163

    UniProtKB/Swiss-Prot: ACTZ_HUMAN, P61163
    Similarity: Belongs to the actin family. ARP1 subfamily


    Function
    for ACTR1A gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ACTZ_HUMAN, P61163
    Function: Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with
    the centrosome

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmid: ACTR1A 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    In Situ Assay
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005524ATP binding IEA--


    ACTR1A for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for ACTR1A:
     Cell cycle / mitosis defect  Synthetic lethal with Ras 


    Pathways & Interactions
    for ACTR1A gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Recruitment of mitotic centrosome proteins and complexes
    		Recruitment of mitotic centrosome proteins and complexes1.00
    		Mitotic G2-G2/M phases0.81
    		Centrosome maturation1.00
    		Loss of proteins required for interphase microtubule organization from the centrosome0.78
    		G2/M Transition0.83
    		Loss of Nlp from mitotic centrosomes0.78
    2Cytoskeleton remodeling Neurofilaments
    		Cytoskeleton remodeling Neurofilaments1.00
    		Cytoplasmic microtubules0.32
    		Cytoskeleton remodeling_Neurofilaments0.91
    3Cell cycle_Spindle assembly and chromosome separation
    		Cell cycle_Spindle assembly and chromosome separation1.00
    		Cell cycle Spindle assembly and chromosome separation0.94
    4Immune System
    		Immune System1.00
    		Adaptive Immune System0.59
    5Cell Cycle
    		Cell Cycle1.00
    		Cell Cycle, Mitotic0.84

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    3 EMD Millipore Pathways for ACTR1A
        Cell cycle Spindle assembly and chromosome separation
    Cytoskeleton remodeling Neurofilaments
    Cytoplasmic microtubules


    2 GeneGo (Thomson Reuters) Pathways for ACTR1A
        Cell cycle Spindle assembly and chromosome separation
    Cytoskeleton remodeling Neurofilaments

    5/12        Reactome Pathways for ACTR1A (see all 12)
        Centrosome maturation
    Cell Cycle
    Recruitment of mitotic centrosome proteins and complexes
    Adaptive Immune System
    Transport of antigen loaded MHC II molecules to surface



    ACTR1A for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ACTR1A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    5/773 Interacting proteins for ACTR1A (P611632, 3 ENSP000003589214) via UniProtKB, MINT, STRING, and/or I2D (see all 773)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCNB1P146352, 3MINT-7945693 MINT-7947479 I2D: score=1 
    UBA5Q9GZZ92, 3MINT-7945693 MINT-7947479 I2D: score=1 
    PRKAG1P546192, 3MINT-7945693 I2D: score=1 
    YWHAEP622582, 3MINT-7947479 I2D: score=1 
    SPTBN1Q010822, 3, ENSP000003492594MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000349259
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086G2/M transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0016192vesicle-mediated transport TAS1528266
    GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class II TAS--


    ACTR1A for ontologies           About GeneDecksing



    Drugs & Compounds
    for ACTR1A gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ACTR1A for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for ACTR1A
    2 Novoseek chemical compound relationships for ACTR1A gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cytochalasin 63.3 1 16731011 (1)
    atp 24.7 2 10074429 (1), 10921911 (1)

    Search CenterWatch for drugs/clinical trials and news about ACTR1A / ACTZ 

    Transcripts
    for ACTR1A gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ACTR1A gene: 
    NM_005736.3  

    Unigene Cluster for ACTR1A:

    ARP1 actin-related protein 1 homolog A, centractin alpha (yeast)
    Hs.153961  [show with all ESTs]
    Unigene Representative Sequence: NM_005736
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369905(uc001kvv.3 uc010qqn.2 uc010qqo.2) ENST00000470322
    ENST00000487599 ENST00000494549 ENST00000481044 ENST00000480947 ENST00000446605
    ENST00000545684

    miRNA
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    8/45 QIAGEN miScript miRNA Assays for microRNAs that regulate ACTR1A (see all 45):
    hsa-miR-3607-3p hsa-miR-429 hsa-miR-15a hsa-miR-106a hsa-miR-30d hsa-miR-449a hsa-miR-9 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmid: ACTR1A 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ACTR1A (see all 7)
    OriGene shRNA RFP: ACTR1A
    OriGene siRNA: ACTR1A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ACTR1A
    Clone
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    Additional cDNA sequence: 

    AK297362.1 AK297620.1 AK302072.1 AK312506.1 BC000693.2 BC026016.2 X82206.1 Z14978.1 

    24/28 DOTS entries (see all 28):

    DT.456372  DT.99950331  DT.100684483  DT.100684480  DT.91764909  DT.95271780  DT.95271796  DT.100684489 
    DT.121224333  DT.95271785  DT.100032293  DT.100672438  DT.95271776  DT.121224342  DT.100769833  DT.100841339 
    DT.86842676  DT.91764913  DT.95316714  DT.100850997  DT.121224347  DT.121224366  DT.121224367  DT.91764912 

    24/762 AceView cDNA sequences (see all 762):

    BU191368 BM551890 BX354157 BX333412 BF942476 CA443237 BU687093 BM691329 
    BE348340 AA985320 CR623554 BM991191 BQ920879 AI432626 BF942094 BM925656 
    AA330535 BQ440603 BM687898 BM703297 AI092489 AA699545 AA468811 CR603093 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for ACTR1A (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b
    SP1:                                      -                             -                 -                           
    SP2:                                      -                             -           -     -     -                     
    SP3:                          -           -                             -                                             
    SP4:                          -     -     -                             -                                             
    SP5:                                                                                                                  


    ECgene alternative splicing isoforms for ACTR1A

    Expression
    for ACTR1A gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ACTR1A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTCACCAGGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ACTR1A expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BoneMandibular CondyleBone
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ACTR1A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ACTR1A

    SOURCE GeneReport for Unigene cluster: Hs.153961
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    In Situ
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    Orthologs
    for ACTR1A gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for ACTR1A gene from 6/27 species (see all 27)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves ACTR1A1 ARP1 actin-related protein 1 homolog A, centractin more 83.24(n)
    97.87(a)    		   423862  NM_001007948.1  NP_001007949.1 
    lizard
    (Anolis carolinensis)    		 Reptilia ACTR1A6
    ACTL86
    (see all 5)    		 --
    		 94(a)
    72(a)
    (see all 5)    		 1 ↔ many
    1 ↔ many
    (see all 5)    		 AAWZ02038352(1873-11960)
    3(39648420-39666181)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.114692 Xenopus laevis transcribed sequence with strong similarity more 79.37(n)    CF289203.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii si:ch211-241j12.36
    		 si:ch211-241j12.3
    		 14(a)
    		 possible ortholog
    		 20(180077-191675)
    fruit fly
    (Drosophila melanogaster)    		 Insecta Arp87C1 , 3 cytoskeleton organization and biogenesis
    structural more3
    Actin-related protein 87C1    		 78(a)3
    71.01(n)1
    79.26(a)1    		   87C53
    415661  NM_079607.21  NP_524331.21 
    worm
    (Caenorhabditis elegans)    		 Secernentea Y53F4B.223
    arp-11    		 actin-like protein3
    Protein ARP-11    		 69(a)3
    62.9(n)1
    70.43(a)1    		   II(15115961-15118715)3
    1751621  NM_064707.31  NP_497108.21 


    ENSEMBL Gene Tree for ACTR1A (if available)
    TreeFam Gene Tree for ACTR1A (if available) 

    Paralogs
    for ACTR1A gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ACTR1A gene
    ACTG22  ACTA22  ACTB2  ACTRT22  ACTC12  ACTL92  ACTRT12  ACTG12  
    ACTL7A2  ACTBL22  ACTL7B2  ACTR1B2  ACTA12  ACTRT32  
    18/31 SIMAP similar genes for ACTR1A using alignment to 3 protein entries:     ACTZ_HUMAN (see all proteins) (see all similar genes):
    ACTR1B    ACT    ACTB    ACTG1    ACTA2    PS1TP5BP1
    ACTG2    ACTC1    ACTBL2    POTEKP    POTEE    POTEF
    POTEI    POTEJ    ACTRT2    ACTRT1    ACTRT3    ACTR2

    ACTR1A for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ACTR1A
    PGOHUM00000240853


    Genomic Variants
    for ACTR1A gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/403 NCBI SNPs in ACTR1A are shown (see all 403)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 10 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1505146671,2
    		--104238503(+) CACCAC/TGCCCG 1 -- ds50010--------
    rs111912961,2
    		C,F,--104238558(+) GGCCAG/CGCTGG 1 -- ds50011Minor allele frequency- C:0.33EA 120
    rs1921746401,2
    		--104238627(+) AGGTGA/TGGCGT 1 -- ds50010--------
    rs1383617221,2
    		--104238637(+) TGAGCC/TACCGT 1 -- ds50010--------
    rs1849786871,2
    		--104238645(+) CGTGCC/TCGGCC 1 -- ds50010--------
    rs1492403421,2
    		--104238762(+) GTGTAC/TACAGG 1 -- ds50010--------
    rs1444054891,2
    		--104239003(+) CGGAAC/TGACTT 1 -- ut310--------
    rs10570411,2
    		C--104239081(-) CTTCTC/TTTAGC 1 -- ut31 trp31Minor allele frequency- T:0.00NA 2
    rs58701,2
    		C,F,O,A,H,--104239100(+) GTTGGT/CTAAGC 1 -- ut3139Minor allele frequency- C:0.37MN EA NA NS WA CSA 5018
    rs1438416201,2
    		--104239117(+) CAGTCC/TGCGGG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ACTR1A (104238986 - 104262512 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ACTR1A: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ACTR1A
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    Disorders / Diseases
    for ACTR1A gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ACTR1A for disorders           About GeneDecksing

    OMIM gene information: 605143    OMIM disorders: --

    6 diseases for ACTR1A:    About MalaCards
    malignant pleural mesothelioma    amyotrophic lateral sclerosis    lateral sclerosis    down syndrome
    malaria    neuronitis


    Export disorders for ACTR1A gene to outside databases

    Publications
    for ACTR1A gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ACTR1A gene, integrated from 9 sources (see all 64):
    (articles sorted by number of sources associating them with ACTR1A)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A vertebrate actin-related protein is a component of a multisubunit complex involved in microtubule-based vesicle motility. (PubMed id 1528266)1, 2, 3, 9 Lees-Miller J.P.... Schroer T.A. (1992)
    2. Beta-centractin: characterization and distribution of a new member of the centractin family of actin-related proteins. (PubMed id 7696711)1, 2, 9 Clark S.W.... Clark I.B. (1994)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Self-regulated polymerization of the actin-related protein Arp1. (PubMed id 10074429)1, 9 Bingham J.B. and Schroer T.A. (1999)
    7. ARP1 interacts with the 5' flanking region of the coagulation factor VII gene. (PubMed id 12871323)1, 9 Carew J.A....Bauer K.A. (2003)
    8. Overexpression of normal and mutant Arp1alpha (centractin) differentially affects microtubule organization during mitosis and interphase. (PubMed id 10504299)1, 9 Clark I.B. and Meyer D.I. (1999)
    9. Regulation of microtubule dynamics by inhibition of t he tubulin deacetylase HDAC6. (PubMed id 19737819)1, 9 Zilberman Y....Bershadsky A. (2009)
    10. Human centromeres and neocentromeres show identical distribution patterns of >20 functionally important kinetochore-associated proteins. (PubMed id 10607828)1, 9 Saffery R....Choo K.H. (2000)

    External Searches for ACTR1A gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    Genome Databases showing ACTR1A gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10121 HGNC: 167 AceView: ACTR1A Ensembl:ENSG00000138107 euGenes: HUgn10121
    ECgene: ACTR1A H-InvDB: ACTR1A

    Other Databases showing ACTR1A gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ACTR1A gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ACTR1A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ACTR1A Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for ACTR1A gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ACTR1A gene:
    Search GeneIP for patents involving ACTR1A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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