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ACTR1A Gene

protein-coding   GIFtS: 61
GCID: GC10M104228

ARP1 Actin-Related Protein 1 Homolog A, Centractin Alpha...

(Previous names: ARP1 (actin-related protein 1, yeast) homolog A (centractin...)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ARP1 Actin-Related Protein 1 Homolog A, Centractin Alpha (Yeast)1 2     actin-RPV2
ARP12 3 5     alpha-centractin2
Centrosome-Associated Actin Homolog2 3     centractin2
CTRN12 3     Actin-RPV3
ARP1 (Actin-Related Protein 1, Yeast) Homolog A (Centractin Alpha)1     Centractin3

External Ids:    HGNC: 1671   Entrez Gene: 101212   Ensembl: ENSG000001381077   OMIM: 6051435   UniProtKB: P611633   

Export aliases for ACTR1A gene to outside databases

Previous GC identifers: GC10M103132 GC10M103472 GC10M104370 GC10M103903 GC10M097872


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ACTR1A Gene:
This gene encodes a 42.6 kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in
size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse
array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and
endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present
in 8-13 copies per dynactin molecule, and is the most abundant molecule in the dynactin complex. It is an
actin-related protein, and is approximately 60% identical at the amino acid level to conventional actin.
(provided by RefSeq, Jul 2008)

GeneCards Summary for ACTR1A Gene:
ACTR1A (ARP1 actin-related protein 1 homolog A, centractin alpha (yeast)) is a protein-coding gene. An important paralog of this gene is ACTG2.

UniProtKB/Swiss-Prot: ACTZ_HUMAN, P61163
Function: Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated
with the centrosome

Gene Wiki entry for ACTR1A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NC_018921.2  NT_030059.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the ACTR1A gene promoter:
         AhR   NF-1   SREBP-1c   FOXD1   LCR-F1   YY1   SREBP-1b   AREB6   Egr-2   SREBP-1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidACTR1A promoter sequence
   Search Chromatin IP Primers for ACTR1A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ACTR1A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24.32   Ensembl cytogenetic band:  10q24.32   HGNC cytogenetic band: 10q24

ACTR1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ACTR1A gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M104228:  view genomic region     (about GC identifiers)

Start:
104,238,986 bp from pter      End:
104,262,512 bp from pter
Size:
23,527 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ACTZ_HUMAN, P61163 (See protein sequence)
Recommended Name: Alpha-centractin  
Size: 376 amino acids; 42614 Da
Secondary accessions: B2R6B0 P42024

Explore the universe of human proteins at neXtProt for ACTR1A: NX_P61163

Explore proteomics data for ACTR1A at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys32, Lys96, Lys200, Lys308
  • Modification sites at PhosphoSitePlus

  • See ACTR1A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005727.1  
    ENSEMBL proteins: 
     ENSP00000358921   ENSP00000473334   ENSP00000406028   ENSP00000438890  
    Reactome Protein details: P61163

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    antibodies-online proteins for ACTR1A (11 products) 

     
    antibodies-online peptides for ACTR1A

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR020902 Actin/actin-like_CS
     IPR004001 Actin_CS
     IPR004000 Actin-related

    Graphical View of Domain Structure for InterPro Entry P61163

    ProtoNet protein and cluster: P61163

    UniProtKB/Swiss-Prot: ACTZ_HUMAN, P61163
    Similarity: Belongs to the actin family. ARP1 subfamily


    Find genes that share domains with ACTR1A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ACTZ_HUMAN, P61163
    Function: Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated
    with the centrosome

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005524ATP binding IEA--
         
    Find genes that share ontologies with ACTR1A           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for ACTR1A:
     Cell cycle / mitosis defect  Synthetic lethal with Ras 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ACTR1A

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    miRTarBase miRNAs that target ACTR1A:
    hsa-mir-193b-3p (MIRT041381), hsa-mir-15a-5p (MIRT000806), hsa-mir-16-5p (MIRT000805), hsa-mir-331-3p (MIRT043350), hsa-mir-92a-3p (MIRT049187), hsa-mir-210-3p (MIRT047006), hsa-mir-148a-5p (MIRT038705)

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    hsa-miR-3607-3p hsa-miR-429 hsa-miR-15a hsa-miR-106a hsa-miR-30d hsa-miR-449a hsa-miR-9 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidACTR1A 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ACTZ_HUMAN, P61163: Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol4
    nucleus3

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005813centrosome IDA--
    GO:0005829cytosol TAS--
    GO:0005856cytoskeleton ----
    GO:0005869dynactin complex TAS7696711

    Find genes that share ontologies with ACTR1A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ACTR1A About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Cytoplasmic microtubules
    Cytoplasmic microtubules0.32
    Cytoskeleton remodeling Neurofilaments0.32
    2Regulation of PLK1 Activity at G2/M Transition
    Recruitment of mitotic centrosome proteins and complexes0.86
    Regulation of PLK1 Activity at G2/M Transition0.77
    Loss of Nlp from mitotic centrosomes0.86
    G2/M Transition0.70
    Centrosome maturation0.86
    Mitotic G2-G2/M phases0.69
    Loss of proteins required for interphase microtubule organizationfrom the centrosome0.86
    3Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    Cell Cycle0.90
    4Class I MHC mediated antigen processing and presentation
    Adaptive Immune System0.41
    5MHC class II antigen presentation
    MHC class II antigen presentation


    Find genes that share SuperPaths with ACTR1A           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 GeneGo (Thomson Reuters) Pathways for ACTR1A
        Cell cycle Spindle assembly and chromosome separation
    Cytoskeleton remodeling Neurofilaments


    5 Reactome Pathways for ACTR1A
        Recruitment of mitotic centrosome proteins and complexes
    Loss of proteins required for interphase microtubule organization,from the centrosome
    Regulation of PLK1 Activity at G2/M Transition
    MHC class II antigen presentation
    Loss of Nlp from mitotic centrosomes


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ACTR1A
    Interactions:

        Search GeneGlobe Interaction Network for ACTR1A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ACTR1A (P611632, 3 ENSP000003589214) via UniProtKB, MINT, STRING, and/or I2D (see all 893)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBA5Q9GZZ92, 3MINT-7945693 MINT-7947479 I2D: score=1 
    PRKAG1P546192, 3MINT-7945693 I2D: score=1 
    YWHAEP622582, 3MINT-7947479 I2D: score=1 
    SPTBN1Q010822, 3, ENSP000003492594MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000349259
    CCNB1P146352, 3, ENSP000002564424MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000256442
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086G2/M transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0016192vesicle-mediated transport TAS1528266
    GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class II TAS--

    Find genes that share ontologies with ACTR1A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ACTR1A (ACTZ)

    2 Novoseek inferred chemical compound relationships for ACTR1A gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cytochalasin 63.3 1 16731011 (1)
    atp 24.7 2 10074429 (1), 10921911 (1)



    Find genes that share compounds with ACTR1A           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ACTR1A gene: 
    NM_005736.3  

    Unigene Cluster for ACTR1A:

    ARP1 actin-related protein 1 homolog A, centractin alpha (yeast)
    Hs.153961  [show with all ESTs]
    Unigene Representative Sequence: NM_005736
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369905(uc001kvv.3 uc010qqn.2 uc010qqo.2) ENST00000470322
    ENST00000487599 ENST00000494549 ENST00000481044 ENST00000480947 ENST00000446605
    ENST00000545684
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    hsa-miR-3607-3p hsa-miR-429 hsa-miR-15a hsa-miR-106a hsa-miR-30d hsa-miR-449a hsa-miR-9 hsa-miR-30a
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    Additional mRNA sequence: 

    AK297362.1 AK297620.1 AK302072.1 AK312506.1 BC000693.2 BC026016.2 X82206.1 Z14978.1 

    Selected DOTS entries (see all 28):

    DT.456372  DT.99950331  DT.100684483  DT.100684480  DT.91764909  DT.95271780  DT.95271796  DT.100684489 
    DT.121224333  DT.95271785  DT.100032293  DT.95271776  DT.121224342  DT.100672438  DT.100769833  DT.100841339 
    DT.86842676  DT.91764913  DT.95316714  DT.100850997  DT.121224347  DT.121224367  DT.91764912  DT.95271763 

    Selected AceView cDNA sequences (see all 762):

    BU656623 BQ932245 BM844446 BP344989 AL524757 BF942476 BQ721133 AI554021 
    CR610318 BQ068797 T36037 BQ420773 BQ961692 BM467779 BP357282 BE897469 
    CA443237 BU521382 BI522645 AI167825 BU191368 BQ920879 BM699301 AA628905 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ACTR1A (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b
    SP1:                                      -                             -                 -                           
    SP2:                                      -                             -           -     -     -                     
    SP3:                          -           -                             -                                             
    SP4:                          -     -     -                             -                                             
    SP5:                                                                                                                  


    ECgene alternative splicing isoforms for ACTR1A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ACTR1A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCACCAGGG
    ACTR1A Expression
    About this image


    ACTR1A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Esophagus (Gastrointestinal Tract)
    ACTR1A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ACTR1A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.153961
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ACTR1A gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Actr1a1 , 5 ARP1 actin-related protein 1 homolog A, centractin more5
    ARP1 actin-related protein 1A, centractin alpha1
    91.4(n)1
    100(a)1
      19 (38.84 cM)5
    541301  NM_016860.11  NP_058556.11 
     463768145 
    chicken
    (Gallus gallus)
    Aves ACTR1A1 ARP1 actin-related protein 1 homolog A, centractin more 83.24(n)
    97.87(a)
      423862  NM_001007948.1  NP_001007949.1 
    lizard
    (Anolis carolinensis)
    Reptilia ACTR1A6
    ARP1 actin-related protein 1 homolog A, centractin...
    94(a)
    1 ↔ 1
    AAWZ02038352(1873-11960)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.114692 Xenopus laevis transcribed sequence with strong similarity more 79.37(n)    CF289203.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch211-241j12.36
    si:ch211-241j12.3
    10(a)
    many ↔ many
    20(180047-203611) ENSDARG00000043963
    fruit fly
    (Drosophila melanogaster)
    Insecta Arp87C3
    Arp11
    cytoskeleton organization and
    biogenesis structural more3
    Actin-related protein 11
    78(a)3
    71.01(n)1
    79.26(a)1
      87C53
    415661  NM_079607.31  NP_524331.21 
    worm
    (Caenorhabditis elegans)
    Secernentea Y53F4B.223
    arp-11
    actin-like protein3
    arp-11
    69(a)3
    62.9(n)1
    70.43(a)1
      II(15115961-15118715)3
    1751621  NM_064707.41  NP_497108.21 


    ENSEMBL Gene Tree for ACTR1A (if available)
    TreeFam Gene Tree for ACTR1A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ACTR1A gene
    ACTG22  ACTA22  ACTRT22  ACTB2  ACTC12  ACTRT12  ACTG12  ACTBL22  
    ACTR1B2  ACTA12  ACTRT32  
    Selected SIMAP similar genes for ACTR1A using alignment to 4 protein entries:     ACTZ_HUMAN (see all proteins) (see all similar genes):
    ACTR1B    ACT    ACTB    ACTA2    ACTG1    PS1TP5BP1
    ACTC1    ACTG2    ACTBL2    POTEM    POTEKP    POTEE
    POTEF    POTEI    POTEJ    ACTRT2    ACTRT1    ACTRT3

    Find genes that share paralogs with ACTR1A           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for ACTR1A
    PGOHUM00000240853


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ACTR1A (see all 461)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs356456201,2
    C--104242537(+) AAAAA-/ATTGCA 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs2014280361,2
    C--104246547(+) TTTTT-/TGAGAC 1 -- int10--------
    rs613622961,2
    C--104246710(+) TTTTT-/TCATAT 1 -- int11Minor allele frequency- T:0.00NA 2
    rs710163861,2
    C--104251827(-) GTCTCA/-AAAAA 1 -- int11Minor allele frequency- -:0.00NA 2
    rs3682042101,2
    C--104254412(+) CCAAC-/CAAA  
            
    CAAAC
    1 -- int10--------
    rs113339781,2
    C--104257410(+) CACAAT/-TTTTT 1 -- int1 trp31Minor allele frequency- -:0.50CSA 2
    rs2016770711,2
    C--104258069(+) AAGTA-/TCTCTCT 1 -- int10--------
    rs2003026761,2
    C--104258081(+) TCTCTC/TTNNNN 1 -- int10--------
    rs354112061,2
    C--104258082(+) TCTCTC/-TTTTT 1 -- int11Minor allele frequency- -:0.50NA 2
    rs802882251,2
    C,F--104258083(+) TCTCTT/CTTTTT 1 -- int15Minor allele frequency- C:0.27NA WA CSA 126

    HapMap Linkage Disequilibrium report for ACTR1A (104238986 - 104262512 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ACTR1A:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv467445CNV Loss19166990
    nsv895970CNV Loss21882294
    nsv831968CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ACTR1A
    DNA2.0 Custom Variant and Variant Library Synthesis for ACTR1A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605143    OMIM disorders: --


    Find genes that share disorders with ACTR1A           About GenesLikeMe


    Export disorders for ACTR1A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ACTR1A gene, integrated from 10 sources (see all 72):
    (articles sorted by number of sources associating them with ACTR1A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A vertebrate actin-related protein is a component of a multisubunit complex involved in microtubule-based vesicle motility. (PubMed id 1528266)1, 2, 3, 9 Lees-Miller J.P.... Schroer T.A. (Nature 1992)
    2. Beta-centractin: characterization and distribution of a new member of the centractin family of actin-related proteins. (PubMed id 7696711)1, 2, 9 Clark S.W.... Clark I.B. (Mol. Biol. Cell 1994)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (Nature 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Self-regulated polymerization of the actin-related protein Arp1. (PubMed id 10074429)1, 9 Bingham J.B. and Schroer T.A. (Curr. Biol. 1999)
    7. ARP1 interacts with the 5' flanking region of the coagulation factor VII gene. (PubMed id 12871323)1, 9 Carew J.A....Bauer K.A. (J. Thromb. Haemost. 2003)
    8. Overexpression of normal and mutant Arp1alpha (centractin) differentially affects microtubule organization during mitosis and interphase. (PubMed id 10504299)1, 9 Clark I.B. and Meyer D.I. (J. Cell. Sci. 1999)
    9. Regulation of microtubule dynamics by inhibition of the tubulin deacetylase HDAC6. (PubMed id 19737819)1, 9 Zilberman Y....Bershadsky A. (J. Cell. Sci. 2009)
    10. Human centromeres and neocentromeres show identical distribution patterns of &gt;20 functionally important kinetochore-associated proteins. (PubMed id 10607828)1, 9 Saffery R....Choo K.H. (Hum. Mol. Genet. 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10121 HGNC: 167 AceView: ACTR1A Ensembl:ENSG00000138107 euGenes: HUgn10121
    ECgene: ACTR1A H-InvDB: ACTR1A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ACTR1A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ACTR1A Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ACTR1A gene:
    Search GeneIP for patents involving ACTR1A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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