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Aliases for ACTR10 Gene

Aliases for ACTR10 Gene

  • Actin Related Protein 10 Homolog 2 3
  • Actin-Related Protein 11 3 4
  • HARP11 3 4
  • ACTR11 3 4
  • Arp11 3 4
  • Actin-Related Protein 10 Homolog (S. Cerevisiae) 2
  • Actin-Related Protein 10 Homolog 5
  • Actin-Related Protein 10 3
  • Arp10 3

External Ids for ACTR10 Gene

Previous GeneCards Identifiers for ACTR10 Gene

  • GC14P052462
  • GC14P056656
  • GC14P057736
  • GC14P058666
  • GC14P038835

Summaries for ACTR10 Gene

GeneCards Summary for ACTR10 Gene

ACTR10 (Actin Related Protein 10 Homolog) is a Protein Coding gene. Among its related pathways are Innate Immune System and Cytoskeleton remodeling Neurofilaments. An important paralog of this gene is ACTL10.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACTR10 Gene

Genomics for ACTR10 Gene

Regulatory Elements for ACTR10 Gene

Enhancers for ACTR10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G058280 1.9 FANTOM5 Ensembl ENCODE dbSUPER 22.6 +81.7 81674 2.4 PKNOX1 ATF1 FEZF1 YY1 TCF12 ZNF766 ELK1 FOS ZNF263 JUNB ACTR10 TOMM20L ENSG00000258682 ARID4A HMGB1P14 PIR55001
GH14G058296 1.7 FANTOM5 ENCODE dbSUPER 6.5 +98.4 98358 4.4 PKNOX1 FOXA2 CREB3L1 ARNT WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 TOMM20L PSMA3-AS1 ARID4A ACTR10 GC14P058345
GH14G058138 0.7 ENCODE 14 -61.7 -61693 0.6 HDAC1 PKNOX1 TAL1 TCF12 ZNF766 GATA2 NCOR1 SMARCE1 RNF2 ZEB2 ACTR10 ENSG00000259969 UBA52P3 PIR47835
GH14G058199 1 ENCODE 0.7 +0.4 359 2.4 ATF1 ARID4B SIN3A DMAP1 FEZF1 GLIS2 ZNF143 ZNF207 KLF7 SP3 PSMA3-AS1 C14orf37 ACTR10 TRK-CTT1-1
GH14G058238 1.8 FANTOM5 Ensembl ENCODE dbSUPER 0.3 +39.4 39430 3.0 PKNOX1 FOXA2 ARID4B E2F7 SIN3A BRCA1 YY1 ZNF121 GTF3C2 ZNF766 PSMA3-AS1 ENSG00000258682 HMGB1P14 C14orf37 ARID4A TRK-CTT1-1 ACTR10
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ACTR10 on UCSC Golden Path with GeneCards custom track

Promoters for ACTR10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000069034 220 2201 ARID4B SIN3A DMAP1 FEZF1 GLIS2 ZNF143 ZNF207 KLF7 SP3 SP5

Genomic Location for ACTR10 Gene

Chromosome:
14
Start:
58,200,080 bp from pter
End:
58,235,636 bp from pter
Size:
35,557 bases
Orientation:
Plus strand

Genomic View for ACTR10 Gene

Genes around ACTR10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACTR10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACTR10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACTR10 Gene

Proteins for ACTR10 Gene

  • Protein details for ACTR10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZ32-ARP10_HUMAN
    Recommended name:
    Actin-related protein 10
    Protein Accession:
    Q9NZ32
    Secondary Accessions:
    • Q9H9Y5
    • Q9NWY2

    Protein attributes for ACTR10 Gene

    Size:
    417 amino acids
    Molecular mass:
    46307 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ACTR10 Gene

Post-translational modifications for ACTR10 Gene

  • Ubiquitination at posLast=2626, posLast=4444, and Lys375
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ACTR10 Gene

Domains & Families for ACTR10 Gene

Gene Families for ACTR10 Gene

Protein Domains for ACTR10 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ACTR10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NZ32

UniProtKB/Swiss-Prot:

ARP10_HUMAN :
  • Belongs to the actin family.
Family:
  • Belongs to the actin family.
genes like me logo Genes that share domains with ACTR10: view

Function for ACTR10 Gene

Gene Ontology (GO) - Molecular Function for ACTR10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with ACTR10: view
genes like me logo Genes that share phenotypes with ACTR10: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ACTR10 Gene

Localization for ACTR10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACTR10 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ACTR10 gene
Compartment Confidence
extracellular 4
lysosome 4
cytoskeleton 3
peroxisome 2
nucleus 2
cytosol 2

Gene Ontology (GO) - Cellular Components for ACTR10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005869 dynactin complex IEA --
GO:0035578 azurophil granule lumen TAS --
genes like me logo Genes that share ontologies with ACTR10: view

Pathways & Interactions for ACTR10 Gene

genes like me logo Genes that share pathways with ACTR10: view

Pathways by source for ACTR10 Gene

Gene Ontology (GO) - Biological Process for ACTR10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007018 microtubule-based movement IEA --
GO:0043312 neutrophil degranulation TAS --
genes like me logo Genes that share ontologies with ACTR10: view

No data available for SIGNOR curated interactions for ACTR10 Gene

Drugs & Compounds for ACTR10 Gene

No Compound Related Data Available

Transcripts for ACTR10 Gene

Unigene Clusters for ACTR10 Gene

Actin-related protein 10 homolog (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ACTR10 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1: -
SP2:
SP3: - -
SP4:
SP5:

Relevant External Links for ACTR10 Gene

GeneLoc Exon Structure for
ACTR10
ECgene alternative splicing isoforms for
ACTR10

Expression for ACTR10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ACTR10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ACTR10 Gene

This gene is overexpressed in Lavage (16.0) and Peripheral blood mononuclear cells (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ACTR10 Gene



Protein tissue co-expression partners for ACTR10 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ACTR10 Gene:

ACTR10

SOURCE GeneReport for Unigene cluster for ACTR10 Gene:

Hs.509451

Evidence on tissue expression from TISSUES for ACTR10 Gene

  • Nervous system(4.9)
  • Blood(2.1)
genes like me logo Genes that share expression patterns with ACTR10: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ACTR10 Gene

Orthologs for ACTR10 Gene

This gene was present in the common ancestor of animals.

Orthologs for ACTR10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ACTR10 35 34
  • 99.85 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ACTR10 34 35
  • 92.57 (n)
dog
(Canis familiaris)
Mammalia ACTR10 34 35
  • 92.01 (n)
mouse
(Mus musculus)
Mammalia Actr10 16 35 34
  • 90.65 (n)
rat
(Rattus norvegicus)
Mammalia Actr10 34
  • 89.85 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ACTR10 35
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ACTR10 35
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 35
  • 85 (a)
OneToMany
ACTR10 34 35
  • 79.3 (n)
lizard
(Anolis carolinensis)
Reptilia ACTR10 35
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia actr10 34
  • 76.58 (n)
Str.5840 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.22802 34
zebrafish
(Danio rerio)
Actinopterygii actr10 34 35
  • 67.47 (n)
zgc55635 34
fruit fly
(Drosophila melanogaster)
Insecta Arp10 34
  • 49.68 (n)
Arp11 35
  • 40 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012077 34
  • 48.77 (n)
worm
(Caenorhabditis elegans)
Secernentea arp-11 35
  • 23 (a)
OneToOne
Species where no ortholog for ACTR10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ACTR10 Gene

ENSEMBL:
Gene Tree for ACTR10 (if available)
TreeFam:
Gene Tree for ACTR10 (if available)

Paralogs for ACTR10 Gene

Variants for ACTR10 Gene

Sequence variations from dbSNP and Humsavar for ACTR10 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000369679 -- 58,229,505(+) AACCC(C/G)GTCTC intron-variant
rs1000390299 -- 58,209,081(+) CACTC(A/G)CTCGT reference, missense, utr-variant-5-prime
rs1000420654 -- 58,229,393(+) AGATT(C/T)TGGGG intron-variant
rs1000485635 -- 58,216,153(+) AGGAT(A/C)TCACT intron-variant
rs1000487983 -- 58,202,380(+) ATCGA(G/T)ACTAT intron-variant

Variation tolerance for ACTR10 Gene

Residual Variation Intolerance Score: 37.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.04; 21.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ACTR10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ACTR10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ACTR10 Gene

Disorders for ACTR10 Gene

Relevant External Links for ACTR10

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ACTR10

No disorders were found for ACTR10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ACTR10 Gene

Publications for ACTR10 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Interactions between the evolutionarily conserved, actin-related protein, Arp11, actin, and Arp1. (PMID: 12857853) Eckley D.M. … Schroer T.A. (Mol. Biol. Cell 2003) 2 3 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 64

Products for ACTR10 Gene

Sources for ACTR10 Gene

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