Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ACTN4 Gene

protein-coding   GIFtS: 68
GCID: GC19P039138

Actinin, Alpha 4

(Previous name: focal segmental glomerulosclerosis 1)
(Previous symbol: FSGS1)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Actinin, Alpha 41 2     FSGS2 5
FSGS11 2 5     ACTININ-42
Focal Segmental Glomerulosclerosis 11 2     Actinin Alpha4 Isoform2
Non-Muscle Alpha-Actinin 42 3     alpha-actinin-42
F-Actin Cross-Linking Protein2 3     

External Ids:    HGNC: 1661   Entrez Gene: 812   Ensembl: ENSG000001304027   OMIM: 6046385   UniProtKB: O437073   

Export aliases for ACTN4 gene to outside databases

Previous GC identifers: GC19P039725 GC19P039529 GC19P043814 GC19P043830 GC19P035584


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ACTN4 Gene:
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins,
including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple
roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles
and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal,
cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help
anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is
concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have
been associated with focal and segmental glomerulosclerosis. (provided by RefSeq, Jul 2008)

GeneCards Summary for ACTN4 Gene: 
ACTN4 (actinin, alpha 4) is a protein-coding gene. Diseases associated with ACTN4 include focal segmental glomerulosclerosis, and focal segmental glomerulosclerosis 2, and among its related super-pathways are Hypertrophic cardiomyopathy (HCM) and Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include actin binding and calcium ion binding. An important paralog of this gene is SPTBN2.

UniProtKB/Swiss-Prot: ACTN4_HUMAN, O43707
Function: F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures.
This is a bundling protein. Probably involved in vesicular trafficking via its association with the CART complex.
The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation

Gene Wiki entry for ACTN4 (Actinin alpha 4) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ACTN4 gene promoter:
         Oct-B1   oct-B3   oct-B2   ATF-2   CUTL1   YY1   POU2F1   POU2F1a   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ACTN4 promoter sequence
   Search SABiosciences Chromatin IP Primers for ACTN4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ACTN4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13

ACTN4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ACTN4 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P039138:  view genomic region     (about GC identifiers)

Start:
39,138,267 bp from pter      End:
39,222,223 bp from pter
Size:
83,957 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ACTN4_HUMAN, O43707 (See protein sequence)
Recommended Name: Alpha-actinin-4  
Size: 911 amino acids; 104854 Da
Subunit: Homodimer; antiparallel (By similarity). Binds TRIM3 at the N-terminus (By similarity). Identified in a
complex with CASK, IQGAP1, MAGI2, NPHS1, SPTAN1 and SPTBN1 (By similarity). Identified in a mRNP granule complex,
at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1,
HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP,
TROVE2, YBX1 and untranslated mRNAs. Component of the CART complex, at least composed of ACTN4, HGS/HRS, MYO5B
and TRIM3. Interacts with BAIAP1 and PDLIM2
Subcellular location: Nucleus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated
mRNAs. Colocalizes with actin stress fibers. Nuclear translocation can be induced by the PI3 kinase inhibitor
wortmannin or by cytochalasin D. Exclusively localized in the nucleus in a limited number of cell lines (breast
cancer cell line MCF-7, oral floor cancer IMC-2, and bladder cancer KU-7)
Sequence caution: Sequence=AAC17470.1; Type=Frameshift; Positions=19, 26, 124, 130, 589, 594, 787, 806;
Sequence=BAA24447.1; Type=Erroneous initiation;
3 PDB 3D structures from and Proteopedia for ACTN4:
1WLX (3D)        1YDI (3D)        2R0O (3D)    
Secondary accessions: O76048

Explore the universe of human proteins at neXtProt for ACTN4: NX_O43707

Explore proteomics data for ACTN4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O43707

  • ACTN4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ACTN4 Protein Expression
    REFSEQ proteins: NP_004915.2  
    ENSEMBL proteins: 
     ENSP00000252699   ENSP00000439497   ENSP00000467190   ENSP00000465176   ENSP00000398393  
     ENSP00000411187  
    Reactome Protein details: O43707
    Human Recombinant Protein Products for ACTN4: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for ACTN4
    OriGene Protein Over-expression Lysate for ACTN4
    OriGene MassSpec for ACTN4 
    OriGene Custom Protein Services for ACTN4
    GenScript Custom Purified and Recombinant Proteins Services for ACTN4
    Novus Biologicals ACTN4 Proteins
    Novus Biologicals ACTN4 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ACTN4 

    Gene Ontology (GO): 5/13 cellular component terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001725stress fiber IEA--
    GO:0005576extracellular region TAS--
    GO:0005634nucleus IDA9508771
    GO:0005737cytoplasm IDA9508771
    GO:0030018Z disc IEA--

    ACTN4 for ontologies           About GeneDecksing



    ACTN4 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of ACTN4
    Browse R&D Systems for Antibodies
    OriGene Antibodies for ACTN4
    OriGene Custom Antibody Services for ACTN4
    GenScript Custom Superior Antibodies Services for ACTN4
    Novus Biologicals ACTN4 Antibodies
    Abcam antibodies for ACTN4
    Cloud-Clone Corp. Antibodies for ACTN4 
    ThermoFisher Antibody for ACTN4
    LSBio Antibodies in human, mouse, rat for ACTN4 

    Assay Products for ACTN4: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ACTN4
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ACTN4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ACTN4 
    Cloud-Clone Corp. CLIAs for ACTN4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    EFHAND: EF-hand domain containing

    5/9 InterPro protein domains (see all 9):
     IPR014837 EF-hand_Ca_insen
     IPR018247 EF_Hand_1_Ca_BS
     IPR002017 Spectrin_repeat
     IPR001715 CH-domain
     IPR011992 EF-hand-like_dom

    Graphical View of Domain Structure for InterPro Entry O43707

    ProtoNet protein and cluster: O43707

    3 Blocks protein domains:
    IPB001589 Actin-binding
    IPB001715 Calponin-like actin-binding
    IPB002017 Spectrin repeat


    UniProtKB/Swiss-Prot: ACTN4_HUMAN, O43707
    Similarity: Belongs to the alpha-actinin family
    Similarity: Contains 1 actin-binding domain
    Similarity: Contains 2 CH (calponin-homology) domains
    Similarity: Contains 2 EF-hand domains
    Similarity: Contains 4 spectrin repeats


    ACTN4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ACTN4_HUMAN, O43707
    Function: F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures.
    This is a bundling protein. Probably involved in vesicular trafficking via its association with the CART complex.
    The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation

         Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001882nucleoside binding IDA12411747
    GO:0003779actin binding TAS8104223
    GO:0005178integrin binding TAS8104223
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI15619032
         
    ACTN4 for ontologies           About GeneDecksing


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Actn4):
     cardiovascular system  cellular  growth/size  homeostasis/metabolism  immune system 
     mortality/aging  renal/urinary system 

    ACTN4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Actn4tm1Plk for ACTN4

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ACTN4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ACTN4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ACTN4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ACTN4 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ACTN4
    8/44 QIAGEN miScript miRNA Assays for microRNAs that regulate ACTN4 (see all 44):
    hsa-miR-142-5p hsa-miR-548j hsa-miR-4307 hsa-miR-548k hsa-miR-605 hsa-miR-374a hsa-miR-3921 hsa-miR-548l
    SwitchGear 3'UTR luciferase reporter plasmidACTN4 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ACTN4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ACTN4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ACTN4
    Sirion Biotech Customized adenovirus for overexpression of ACTN4

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for ACTN4 (see all 7)
    OriGene ORF clones in mouse, rat for ACTN4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ACTN4 (NM_004924)
    Sino Biological Human cDNA Clone for ACTN4
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ACTN4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACTN4
    Sirion Biotech Customized lentivirus for stable overexpression of ACTN4 
                         Customized lentivirus expression plasmids for stable overexpression of ACTN4 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ACTN4
    Search LifeMap BioReagents cell lines for ACTN4
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACTN4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ACTN4 About   (see all 22)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Hypertrophic cardiomyopathy (HCM)
    Arrhythmogenic right ventricular cardiomyopathy (ARVC)0.54
    Arrhythmogenic right ventricular cardiomyopathy0.53
    2Sertoli-Sertoli Cell Junction Dynamics
    Sertoli-Sertoli Cell Junction Dynamics0.38
    Epithelial Tight Junctions0.36
    Germ Cell-Sertoli Cell Junction Dynamics0.38
    3Cell adhesion Integrin-mediated cell adhesion and migration
    Cell adhesion Integrin-mediated cell adhesion and migration0.49
    Cytoskeleton remodeling Fibronectin-binding integrins in cell motility0.32
    Cytoskeleton remodeling Integrin outside-in signaling0.37
    4Platelet degranulation
    Platelet degranulation 0.94
    Response to elevated platelet cytosolic Ca2+0.94
    5Platelet activation, signaling and aggregation
    Hemostasis0.43
    Platelet activation, signaling and aggregation0.43

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5 EMD Millipore Pathways for ACTN4
        Cell adhesion Integrin-mediated cell adhesion and migration
    Cytoskeleton remodeling Integrin outside-in signaling
    Cytoskeleton remodeling Fibronectin-binding integrins in cell motility
    Cell adhesion Endothelial cell contacts by junctional mechanisms
    Cell adhesion Endothelial cell contacts by non-junctional mechanisms

    5/6 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ACTN4 (see all 6)
        Sertoli-Sertoli Cell Junction Dynamics
    ILK Signaling
    Remodeling of Adherens Junctions
    Epithelial Tight Junctions
    Germ Cell-Sertoli Cell Junction Dynamics

    5/6 GeneGo (Thomson Reuters) Pathways for ACTN4 (see all 6)
        Cell adhesion Endothelial cell contacts by non-junctional mechanisms
    Cytoskeleton remodeling Integrin outside-in signaling
    Cell adhesion Integrin-mediated cell adhesion and migration
    Cell adhesion Endothelial cell contacts by junctional mechanisms
    Inhibitory action of Lipoxins on neutrophil migration

    2 BioSystems Pathways for ACTN4
        Striated Muscle Contraction
    Arrhythmogenic right ventricular cardiomyopathy


    5/6        Reactome Pathways for ACTN4 (see all 6)
        Hemostasis
    Nephrin interactions
    Platelet degranulation
    Platelet activation, signaling and aggregation
    Cell-Cell communication


    5/9         Kegg Pathways  (Kegg details for ACTN4) (see all 9):
        Focal adhesion
    Adherens junction
    Tight junction
    Leukocyte transendothelial migration
    Regulation of actin cytoskeleton


    ACTN4 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ACTN4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/156 Interacting proteins for ACTN4 (O437071, 2, 3 ENSP000002526994) via UniProtKB, MINT, STRING, and/or I2D (see all 156)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TJP1Q071571, 2, 3, ENSP000002815374EBI-351526,EBI-79553 MINT-3088497 MINT-3088449 MINT-3088309 MINT-2984673 I2D: score=7 STRING: ENSP00000281537
    COILP384322, 3, ENSP000002403164MINT-2856455 I2D: score=3 STRING: ENSP00000240316
    SACSQ9NZJ42, 3, ENSP000003717294MINT-2856495 I2D: score=3 STRING: ENSP00000371729
    MAP3K3Q997592, 3MINT-48410 I2D: score=2 
    RIPK3Q9Y5722, 3MINT-49099 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001666response to hypoxia IEA--
    GO:0002576platelet degranulation TAS--
    GO:0007596blood coagulation TAS--
    GO:0015031protein transport IEA--
    GO:0030168platelet activation TAS--

    ACTN4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ACTN4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ACTN4

    4 Novoseek inferred chemical compound relationships for ACTN4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 5.23 8 19833736 (1), 19920151 (1)
    calcium 0 3 15843471 (1), 19206166 (1)
    threonine 0 1 12239280 (1)
    serine 0 1 12239280 (1)

    Search CenterWatch for drugs/clinical trials and news about ACTN4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ACTN4 gene: 
    NM_004924.4  

    Unigene Cluster for ACTN4:

    Actinin, alpha 4
    Hs.270291  [show with all ESTs]
    Unigene Representative Sequence: NM_004924
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000588618 ENST00000252699(uc010egc.2 uc002oja.2 uc021uug.1)
    ENST00000390009 ENST00000589528 ENST00000495553 ENST00000586538 ENST00000489451
    ENST00000440400 ENST00000497637 ENST00000477174 ENST00000424234

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ACTN4
    8/44 QIAGEN miScript miRNA Assays for microRNAs that regulate ACTN4 (see all 44):
    hsa-miR-142-5p hsa-miR-548j hsa-miR-4307 hsa-miR-548k hsa-miR-605 hsa-miR-374a hsa-miR-3921 hsa-miR-548l
    SwitchGear 3'UTR luciferase reporter plasmidACTN4 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ACTN4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ACTN4
    Clone
    Products:
         
    OriGene clones in human, mouse for ACTN4 (see all 7)
    OriGene ORF clones in mouse, rat for ACTN4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ACTN4 (NM_004924)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ACTN4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACTN4
    Sirion Biotech Customized lentivirus for stable overexpression of ACTN4 
                         Customized lentivirus expression plasmids for stable overexpression of ACTN4 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ACTN4
    OriGene qSTAR qPCR primer pairs in human, mouse for ACTN4
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ACTN4
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ACTN4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ACTN4

    Additional mRNA sequence: 

    AK299955.1 AK304554.1 AK309361.1 AK309363.1 AK309364.1 BC005033.1 BC015620.2 BC107062.1 
    BX647098.1 D89980.1 DQ431186.1 GU987085.1 Z36797.1 

    24/50 DOTS entries (see all 50):

    DT.454297  DT.92038152  DT.100857867  DT.95220089  DT.87077774  DT.100857868  DT.100857861  DT.100857862 
    DT.95249964  DT.95211807  DT.91923640  DT.95220202  DT.92330587  DT.102839407  DT.100857884  DT.121498871 
    DT.121498968  DT.100034739  DT.100857877  DT.92459345  DT.92459353  DT.95339553  DT.100045174  DT.92459310 

    24/987 AceView cDNA sequences (see all 987):

    BQ941049 BF197468 CA393248 AA283777 CF125802 BQ679209 BM564345 BU149522 
    BU190965 BG419792 AW502037 AI866955 BF037108 BM981136 BE744413 AI076919 
    AI498118 AA700560 BP431592 AA405283 AA368529 AW073755 BQ015016 BG108139 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for ACTN4 (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^
    SP1:                                                                          -                                                                                 
    SP2:                                                                    -                                                                                       
    SP3:                                                                                                                                                            
    SP4:                          -     -     -     -     -     -     -     -     -     -     -                                                                     
    SP5:                                                                    -                                                                                       

    ExUns: 20a · 20b ^ 21a · 21b ^ 22a · 22b ^ 23a · 23b · 23c · 23d ^ 24
    SP1:  -           -     -                                             
    SP2:                                                                  
    SP3:  -     -     -                                                   
    SP4:                                                                  
    SP5:                                                                  


    ECgene alternative splicing isoforms for ACTN4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ACTN4 expression in normal human tissues (normalized intensities)      ACTN4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGAGGGGCCA
    ACTN4 Expression
    About this image


    ACTN4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Kidney (Urinary System)
             Podocytes Podocyte Layer

    See ACTN4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ACTN4

    SOURCE GeneReport for Unigene cluster: Hs.270291

    UniProtKB/Swiss-Prot: ACTN4_HUMAN, O43707
    Tissue specificity: Widely expressed

        SABiosciences Expression via Pathway-Focused PCR Arrays including ACTN4: 
              Adherens Junctions in human mouse rat
              Tight Junctions in human mouse rat
              Focal Adhesions in human mouse rat
              Cell Motility in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ACTN4
    OriGene qSTAR qPCR primer pairs in human, mouse for ACTN4
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ACTN4
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ACTN4
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ACTN4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACTN4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ACTN4 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Actn41 , 5 actinin alpha 41, 5 90.89(n)1
    98.57(a)1
      7 (16.94 cM)5
    605951  NM_021895.21  NP_068695.11 
     288932485 
    chicken
    (Gallus gallus)
    Aves ACTN41 actinin, alpha 4 87.02(n)
    93.14(a)
      396024  NM_205126.1  NP_990457.1 
    lizard
    (Anolis carolinensis)
    Reptilia ACTN46
    --
    Uncharacterized protein
    91(a)
    78(a)
    1 ↔ 1
    possible ortholog
    GL343665.1(143759-312977)
    GL343832.1(92406-123216)
    zebrafish
    (Danio rerio)
    Actinopterygii wufb53f052 wufb53f05 79.58(n)   322221  BC054901.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Actn3 cytoskeletal anchoring actin binding 67(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea atn-16
    Protein ATN-1, isoform a
    59(a)
    1 → many
    V(12478413-12484452)


    ENSEMBL Gene Tree for ACTN4 (if available)
    TreeFam Gene Tree for ACTN4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ACTN4 gene
    SPTBN22  SYNE22  SPTA12  SPTBN42  SPTB2  SPTBN12  ACTN22  SPTBN52  
    SPTAN12  SYNE12  ACTN12  CLMN2  
    17 SIMAP similar genes for ACTN4 using alignment to 8 protein entries:     ACTN4_HUMAN (see all proteins):
    MLL-ACTN4    ACTN2    ACTN1    ACTN3    MACF1    HSpTB1
    SPTBN2    SPNB4    SPTBN4    SPTBN1    SPTB    CALM2
    CALM1    CALM3    SPTAN1    CETN3    CLMN

    ACTN4 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for ACTN4
    PGOHUM00000244677 PGOHUM00000246045


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1937 SNPs in ACTN4 are shown (see all 1937)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0103804
    Focal segmental glomerulosclerosis 1 (FSGS1)4--see VAR_0103802 S P mis40--------
    VAR_0103794
    Focal segmental glomerulosclerosis 1 (FSGS1)4--see VAR_0103792 T I mis40--------
    VAR_0103784
    Focal segmental glomerulosclerosis 1 (FSGS1)4--see VAR_0103782 K E mis40--------
    rs1998032271,2
    C--35597129(+) ATGATC/TTTTTT 1 -- int10--------
    rs1490482981,2
    C--35616790(+) TGTGC-/GTGTGTGT
    /GTGTGTGTGT
    GTGTG
    1 -- int10--------
    rs114524021,2
    C--35631949(+) AGATAA/-TATCG 1 -- int11Minor allele frequency- -:0.00NA 2
    rs609375731,2
    C--39147787(+) TTTTTT/-GAGAT 1 -- int11Minor allele frequency- -:0.50NA 2
    rs584741891,2
    C--39151623(+) AGAGA-/GAACCAA 1 -- int10--------
    rs567443001,2
    C--39153017(+) GCACT-/GA    
       T
    /TGA
    GATGA
    2 -- cds10--------
    rs730326971,2
    C,F--39163197(+) ATTTGA/GTCTAT 1 -- int13Minor allele frequency- G:0.14NA WA 240

    HapMap Linkage Disequilibrium report for ACTN4 (39138267 - 39222223 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for ACTN4:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv641e199CNV Deletion23128226
    esv2718535CNV Deletion23290073
    nsv911668CNV Loss21882294
    nsv833828CNV Loss17160897
    nsv911669CNV Loss21882294
    esv22820CNV Loss19812545
    nsv833826CNV Loss17160897
    nsv817834CNV Gain17921354
    nsv833827CNV Gain17160897
    nsv911667CNV Gain21882294


    Human Gene Mutation Database (HGMD): ACTN4
    SABiosciences Cancer Mutation PCR Assays
    1 SABiosciences qBiomarker Copy Number PCR Array containing ACTN4:
    Ovarian Cancer
    SeqTarget long-range PCR primers for resequencing ACTN4
    DNA2.0 Custom Variant and Variant Library Synthesis for ACTN4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604638   
    OMIM disorders: 603278  
    UniProtKB/Swiss-Prot: ACTN4_HUMAN, O43707
  • Focal segmental glomerulosclerosis 1 (FSGS1) [MIM:603278]: A renal pathology defined by the presence of
    segmental sclerosis in glomeruli and resulting in proteinuria, reduced glomerular filtration rate and progressive
    decline in renal function. Renal insufficiency often progresses to end-stage renal disease, a highly morbid state
    requiring either dialysis therapy or kidney transplantation. Note=The disease is caused by mutations affecting
    the gene represented in this entry

  • 20/41 diseases for ACTN4 (see all 41):    About MalaCards
    focal segmental glomerulosclerosis    focal segmental glomerulosclerosis 2    nephrosis    frasier syndrome
    steroid-resistant nephrotic syndrome    thin basement membrane nephropathy    proteinuria    nephrotic syndrome
    crescentic glomerulonephritis    ovarian clear cell adenocarcinoma    sickle cell anemia    clear cell adenocarcinoma
    wilms tumor    protein s deficiency    endocarditis    glomerulonephritis
    esophageal cancer    macular degeneration    kidney disease    oral squamous cell carcinoma

    3 diseases from the University of Copenhagen DISEASES database for ACTN4:
    Nephrotic syndrome     Glomerulonephritis     Proteinuria

    ACTN4 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/14 Novoseek inferred disease relationships for ACTN4 gene (see all 14)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nphs1 90.9 7 15780077 (1), 18443213 (1), 16186681 (1), 16752799 (1) (see all 7)
    glomerulosclerosis, focal segmental 90.5 30 19666657 (2), 16251236 (2), 18436095 (2), 19142020 (2) (see all 17)
    nephrotic syndrome 78.9 13 15031339 (2), 15780077 (1), 11793093 (1), 19956976 (1) (see all 9)
    glomerulosclerosis 73.4 5 17082197 (1), 12782671 (1), 19956976 (1), 15627790 (1)
    proteinuria 71 9 11730159 (1), 11793093 (1), 17082197 (1), 12761234 (1) (see all 7)
    nephrosis 52.7 2 15031339 (1)
    renal disease 52.5 4 16841182 (1), 18164029 (1), 19652713 (1)
    renal failure chronic 41.1 3 12617336 (2)
    wilms tumor 31.7 2 14569107 (2)
    renal failure 31.4 2 17082197 (1), 19838113 (1)

    Genetic Association Database (GAD): ACTN4
    Human Genome Epidemiology (HuGE) Navigator: ACTN4 (8 documents)

    Export disorders for ACTN4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ACTN4 gene, integrated from 9 sources (see all 220):
    (articles sorted by number of sources associating them with ACTN4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mutations in ACTN4, encoding alpha-actinin-4, cause familial focal segmental glomerulosclerosis. (PubMed id 10700177)1, 2, 3, 9 Kaplan J.M.... Pollak M.R. (2000)
    2. ACTN4 gene mutations and single nucleotide polymorphi sms in idiopathic focal segmental glomerulosclerosis. (PubMed id 19142020)1, 4, 9 Dai S....Chen N. (2009)
    3. The human non-muscle alpha-actinin protein encoded by the ACTN4 gene suppresses tumorigenicity of human neuroblastoma cells. (PubMed id 10656685)1, 2, 9 Nikolopoulos S.N.... Ross R.A. (2000)
    4. Association analysis of podocyte slit diaphragm genes as candidates for diabetic nephropathy. (PubMed id 17968527)1, 4, 9 Ihalmo P....Groop P.H. (2008)
    5. Human Variation in Alcohol Response Is Influenced by Variation in Neuronal Signaling Genes. (PubMed id 20201926)1, 4 Joslyn G....White R.L. (2010)
    6. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    7. The R229Q mutation in NPHS2 may predispose to proteinuria in thin-basement-membrane nephropathy. (PubMed id 18726620)1, 4 Tonna S....Savige J. (2008)
    8. Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry. (PubMed id 17370265)1, 2 Denis N.J.... Figeys D. (2007)
    9. Molecular composition of IMP1 ribonucleoprotein granules. (PubMed id 17289661)1, 2 Joeson L.... Nielsen F.C. (2007)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1, 2 Kimura K.... Sugano S. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 81 HGNC: 166 AceView: ACTN4 Ensembl:ENSG00000130402 euGenes: HUgn81
    ECgene: ACTN4 Kegg: 81 H-InvDB: ACTN4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ACTN4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ACTN4 Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/ACTN4

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ACTN4 gene:
    Search GeneIP for patents involving ACTN4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse Kits and Assays available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Small Molecules at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of ACTN4
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for ACTN4   OriGene RNAi products in human, mouse, rat for ACTN4  
     OriGene qPCR primer pairs and template standards for ACTN4   OriGene Protein Over-expression Lysate for ACTN4  
     OriGene MassSpec something-or-other for ACTN4   OriGene clones in human, mouse for ACTN4  
     OriGene qSTAR qPCR primer pairs in human, mouse for ACTN4   OriGene Purified Protein for ACTN4  
     OriGene ORF clones in mouse, rat for ACTN4   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ACTN4   OriGene Custom Protein Services for ACTN4  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ACTN4
     QIAGEN SeqTarget long-range PCR primers for resequencing ACTN4
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ACTN4
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ACTN4
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ACTN4
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ACTN4
     GenScript Custom Purified and Recombinant Proteins Services for ACTN4 GenScript cDNA clones with any tag delivered in your preferred vector for ACTN4
     GenScript Custom Assay Services for ACTN4 GenScript Custom Superior Antibodies Services for ACTN4
     GenScript Custom overexpressing Cell Line Services for ACTN4 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in ACTN4 promoter
     Search Chromatin IP Primers for ACTN4
     RT2 qPCR Primer Assay in human, mouse, rat ACTN4
     GNC Network for ACTN4
     SABiosciences PCR Arrays including human, mouse, rat ACTN4
     Search Tocris compounds for ACTN4
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for ACTN4
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     ACTN4 antibodies
     ACTN4 proteins
     ACTN4 lysates
     Antibodies for ACTN4
     See all of Abcam's Antibodies, Kits and Proteins for ACTN4
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for ACTN4
     Antibodies for ACTN4
     ELISAs for ACTN4
     CLIAs for ACTN4
     Search LifeMap BioReagents cell lines for ACTN4
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACTN4
     SwitchGear 3'UTR luciferase reporter plasmids for ACTN4
     SwitchGear Promoter luciferase reporter plasmids for ACTN4
     ThermoFisher Antibody for ACTN4
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACTN4
     inGenious Targeting Laboratory - Custom generated mouse model solutions for ACTN4
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ACTN4
    Customized:
     lentivirus for stable overexpression of ACTN4
     lentivirus expression plasmids for stable overexpression of ACTN4
     adenovirus for overexpression of ACTN4
     LSBio Antibodies in human, mouse, rat for ACTN4
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ACTN4 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4