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ACTN1 Gene

protein-coding GIFtS: 65

GC14M068410

actinin, alpha 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
FLJ40884 ^²
FLJ54432 ^²

Descriptions
Alpha-actinin cytoskeletal isoform ^³
F-actin cross-linking protein ^², ³
Non-muscle alpha-actinin-1 ^³
actinin 1 smooth muscle ^²
actinin, alpha 1 ^²
alpha-actinin 1 ^²

External Ids
HGNC: 163¹
Entrez Gene: 87²
UniProtKB: P12814³
Ensembl: ENSG00000072110⁷

Search outside databases for aliases for ACTN1 gene

Previous GC identifers: GC14M066846 GC14M063137 GC14M067330 GC14M067331

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ACTN1:

Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of

cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an

actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the

cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is

involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle

isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the

myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform

and maps to the same site as the structurally similar erythroid beta spectrin gene. Three

transcript variants encoding different isoforms have been found for this gene. [provided by

RefSeq]

UniProtKB/Swiss-Prot: ACTN1_HUMAN, P12814

Function: F-actin cross-linking protein which is thought to anchor actin to a variety of

intracellular structures. This is a bundling protein

Gene Wiki entry for ACTN1 (Actinin%2C_alpha_1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ACTN1 gene

Entrez Gene cytogenetic band: 14q24.1-q24.2|14q24|14q22-q24 Ensembl cytogenetic band: 14q24.1 HGNC cytogenetic band: 14q24.1

ACTN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14M068410: (about GC identifiers)

Start:	68,410,793 bp from pter
End:	68,515,763 bp from pter
Size:	104,971 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000014.7 NT_026437.11

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: ACTN1_HUMAN, P12814 (See protein sequence)

Recommended Name: Alpha-actinin-1

Size: 892 amino acids; 103058 Da

Subunit: Homodimer; antiparallel. Interacts with DDN, MYOZ2, PDLIM2, TTID and LPP

Subcellular location: Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z-disk.

Note=Colocalizes with MYOZ2 and PPP3CA at the Z-line of heart and skeletal muscle

PDB structure from and Proteopedia :

2EYI (3D)

2EYN (3D)

Secondary accessions: Q9BTN1

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (3 alternative transcripts):

NP_001093.1 NP_001123476.1 NP_001123477.1

ENSEMBL proteins:

ENSP00000193403 ENSP00000377941

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (alpha Actinin)
	Human Recombinant Proteins from Abnova (ACTN1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005730	nucleolus	IDA	18029348
GO:0005737	cytoplasm	IEA	--
GO:0005856	cytoskeleton	IEA	--
GO:0005925	focal adhesion	IMP	16807302
GO:0031143	pseudopodium	TAS	1629252

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Antibodies for ACTN1:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of ACTN1
	Sigma-Aldrich Antibody Arrays and Antibodies for ACTN1
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for ACTN1
	Antibodies from Abcam (alpha Actinin), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ACTN1)
	Novus Biologicals Antibodies for ACTN1

Assays for ACTN1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P12814

ProtoNet protein and cluster: P12814

3 Blocks protein families:

IPB001589 Actin-binding

IPB001715 Calponin-like actin-binding

IPB002017 Spectrin repeat

UniProtKB/Swiss-Prot: ACTN1_HUMAN, P12814

Similarity: Belongs to the alpha-actinin family

Similarity: Contains 1 actin-binding domain

Similarity: Contains 2 CH (calponin-homology) domains

Similarity: Contains 2 EF-hand domains

Similarity: Contains 4 spectrin repeats

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ACTN1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ACTN1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001130004

Applied Biosystems Silencer® siRNAs for ACTN1

Sigma-Aldrich siRNA for ACTN1

Sigma-Aldrich shRNA Panels and shRNA for ACTN1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ACTN1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001102
Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001102
untagged cDNA clones in CMV expression vector (see all 4): NM_001102

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001130004

UniProtKB/Swiss-Prot: ACTN1_HUMAN, P12814

Function: F-actin cross-linking protein which is thought to anchor actin to a variety of

intracellular structures. This is a bundling protein

Genatlas biochemistry entry for ACTN1:

actinin,alpha 1,actin filament cross-linking,calcium sensitive,cytoskeletal type,expressed in non

muscle cells

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003779	actin binding	IEA	--
GO:0005178	integrin binding	IDA	7983147
GO:0005509	calcium ion binding	IEA	--
GO:0005515	protein binding	IPI	10793131
GO:0017166	vinculin binding	IPI	15988023

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5 Sigma-Aldrich "Your Favorite Gene" Pathways for ACTN1 (Your Favorite Gene powered by Ingenuity)

Germ Cell-Sertoli Cell Junction Signaling
Integrin Signaling
Actin Cytoskeleton Signaling
Leukocyte Extravasation Signaling
VEGF Signaling

GeneDecks ACTN1 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for ACTN1

5/92 Interacting proteins for ACTN1 (P12814^{1, 2} ENSP00000193403³) via UniProtKB, MINT, and/or STRING (see all 92 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MYOZ1	Q9NP98², ENSP00000352272³	MINT-68434 STRING (score=.906)
SRC	P12931¹^,²	EBI-351710, EBI-621482 MINT-6795322 EBI-351710, EBI-621482 MINT-6795322
PTPN1	P18031¹	EBI-351710, EBI-968788
SRC	P12931¹^,²	EBI-351710, EBI-621482 MINT-6795322 EBI-351710, EBI-621482 MINT-6795322
ATXN2	Q99700²	MINT-2856533 MINT-2856514

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3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0042981	regulation of apoptosis	NAS	16807302
GO:0048041	focal adhesion formation	IMP	16807302
GO:0051271	negative regulation of cell motion	IMP	7983147

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ACTN1
1 Novoseek chemical compound relationship for ACTN1 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	11.53	4	17898132 (2), 11802708 (1), 16547650 (1)

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(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ACTN1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ACTN1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001130004

Sigma-Aldrich siRNA for ACTN1

Sigma-Aldrich shRNA Panels and shRNA for ACTN1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001102 NM_001130004 NM_001130005

REFSEQ mRNAs for ACTN1 gene (3 alternative transcripts):

NM_001102.3 NM_001130004.1 NM_001130005.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001102 NM_001130004 NM_001130005

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001102
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001102
                                 untagged cDNA clones in CMV expression vector (see all 4): NM_001102

Additional cDNA sequence:

AJ844628.2 AK022224.1 AK098203.1 AK124378.1 AK225782.1 AK294317.1 AK295099.1 AK298496.1

AK299362.1 BC003576.1 BC004984.1 BC015766.1 BC127124.1 BT007207.1 BX248020.1 BX641076.1

CR609497.1 CR620987.1 DQ496098.1 EU716325.1 FJ410030.1 M95178.1 X15804.1 X55187.1

24/55 DOTS entries (see all 55 ):

DT.100771871 DT.100887428 DT.100766388 DT.91823921 DT.91782289 DT.95125704 DT.87017777 DT.120785717

DT.100887439 DT.91782278 DT.91679968 DT.102839930 DT.100887429 DT.100887448 DT.95287775 DT.100887434

DT.120785745 DT.100887445 DT.95276950 DT.91971379 DT.100660649 DT.100887419 DT.75110244 DT.91818067

24/699 AceView cDNA sequences (see all 699 ):

AU124830 BE312967 BM762824 AW084267 BC003576 BU621901 BQ010008 AI139065

W51764 BQ017489 AW071868 BM709038 BQ649552 AA418035 BM695526 BM915810

BM802096 BE701572 AI082078 CF890756 BU520922 BM676908 CD365004 BQ021240

highest scoring ESTs for ACTN1:

X15804 M95178 AK098203 AU098889 AU121135 AU121719 AU128840 AU130638 AU132715 AU280791

Unigene Cluster for ACTN1:

Actinin, alpha 1

Hs.509765 [show with all ESTs]

Unigene Representative Sequence: BX641076

GeneLoc Exon Structure

5/12 Alternative Splicing Database (ASD) splice patterns (SP) for ACTN1 (see all 12 )

ExUns:	1a	·	1b	^	2	^	3	^	4a	·	4b	^	5	^	6	^	7	^	8	^	9	^	10a	·	10b	^	11	^	12a	·	12b	^	13a	·	13b	^	14a	·	14b	^	15	^	16a	·	16b	^	17	^	18a	·	18b	^
SP1:					-		-				-																										-
SP2:																																					-
SP3:
SP4:
SP5:					-		-		-		-		-

ExUns:	19a	·	19b	^	20a	·	20b	^	21a	·	21b	^	22	^	23	^	24a	·	24b
SP1:	-						-						-
SP2:	-						-		-		-
SP3:
SP4:	-						-		-		-		-
SP5:

About this scheme

ECgene alternative splicing isoforms for ACTN1

2 Ensembl transcripts including schematic representations:

ENST00000193403 ENST00000394419

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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ACTN1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ACTN1

¹ / ² / ³

10 probe-sets matching ACTN1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
39330_s_at²^{, 3}	U95-A	1	1.00	1.00	0.98	0.90	M95178	1.00	0.90	0.95	1
39329_at²^{, 3}	U95-A	1	1.00	1.00	0.98	1.10	X15804	1.00	1.00	1.00	1
208637_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BC003576	0.80	1.00	0.91	1
208636_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AI082078	0.60	1.00	0.82	1
211160_x_at²^{, 3}	U133-A	2	1.00	0.95	--	--	M95178	1.00	0.90	0.95	1
200943_at²	U133-A	7	0.91	0.19	--	--	--	--	--	--	--
208637_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
208636_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
211160_x_at²	U133Plus2	2	1.00	0.95	--	--	--	--	--	--	--
200943_at²	U133Plus2	7	0.91	0.19	--	--	--	--	--	--	--

GeneDecks ACTN1 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TCCTTCTCCA

SOURCE GeneReport for Unigene cluster: Hs.509765
Expression variation in blood from EXPOLDB for ACTN1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for ACTN1 gene from 5/11 species (see all 11 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ACTN1¹	--	actinin, alpha 1	94.06(n) 99.33(a)	480369 XM_848010.1 XP_853103.1
chimpanzee (Pan troglodytes)	ACTN1¹	--	actinin, alpha 1	98.65(n) 98.88(a)	452993 XM_001139826.1 XP_001139826.1
cow (Bos taurus)	ACTN1¹	--	actinin, alpha 1	94.13(n) 99.44(a)	524770 NM_001035351.1 NP_001030428.1
rat (Rattus norvegicus)	Actn1¹	--	actinin, alpha 1	91.7(n) 99.33(a)	81634 NM_031005.2 NP_112267.1
mouse (Mus musculus)	Actn1^{1, 5}	12 (35.00 cM)⁵	actinin, alpha 1^{1, 5}	91.52(n)¹ 99.22(a)¹	109711¹ NM_134156.1¹ NP_598917.1¹ AI195392⁵ AK014073⁵ (see all 18)

About this table Species with no ortholog for ACTN1

ENSEMBL Gene Tree for ACTN1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for ACTN1 gene

ACTN2² ACTN4² ACTN3²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/650 NCBI SNPs in ACTN1 are shown (see all 650 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 272)

AB	SNP ID	Valid	Chr 14 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs181454^1,2	A,C,F,H,O	68410295(+)	`TGTTCA/CCTGCA`	1	--	ng5¹		12	EU EA WA NA	1054
	rs181455^1,2	A,C,F,H	68410322(+)	`TGGGGT/GGAATG`	1	--	ng5¹		4	EU EA WA	420
	rs1007407^1,2	A,C,F,H	68516713(-)	`GCCTCA/GGTTTC`	1	--	ng3¹ tfbs³		12	EA NA MN EU WA	1086
	rs1475034^1,2	C,F,H	68410513(-)	`CTACTC/ACTAAT`	1	--	ng5¹		8	EU EA WA	840
	rs181456^1,2	A,C,F	68410352(+)	`TGGTGC/TCGTGG`	1	--	ng5¹		3	NA	142
	rs3809393^1,2	C,F,H	68515866(+)	`CAGGCC/AGAGTT`	1	--	ng3¹		6	EU EA WA NA	596
--	rs11557769^1,2	C,F	68411406(-)	`CCTACA/TCCGGC`	3	T/S	mis¹ ese³		4	EU EA WA	420
--	rs1054235^1,2	H	68415491(-)	`TCATCA/TGCTTG`	2	S/C	mis¹		3	MN EU WA	408
	rs12237^1,2	F	68410953(+)	`AGATAG/TAAGAA`	3	--	ut3¹		1	MN	184
	rs1054992^1,2	F	68410857(-)	`ATTGGG/TGCATG`	3	--	ut3¹		1	MN	184

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HapMap Linkage Disequilibrium images for ACTN1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 102575

1 Novoseek disease relationship for ACTN1 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tumors	0.00	5	18320066 (3)

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1 PharmGKB disease relationship for ACTN1 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1	FA GN	12086872

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(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/120 PubMed articles for ACTN1 gene (see all 120 ):

Cloning and chromosomal localization of the human cytoskeletal alpha- actinin gene reveals linkage to the beta-spectrin gene. (PubMed id 2349951)^{2, 3, 4} Youssoufian H.... Kwiatkowski D.J. (1990)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
Global phosphoproteome analysis on human HepG2 hepatocytes using reversed-phase diagonal LC. (PubMed id 16097034)^{3, 4} Gevaert K.... Vandekerckhove J. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)^{3, 4} Gevaert K.... Vandekerckhove J. (2003)
The lipoma preferred partner LPP interacts with alpha-actinin. (PubMed id 12615977)^{3, 4} Li B.... Trueb B. (2003)
The cytoskeletal/non-muscle isoform of alpha-actinin is phosphorylated on its actin-binding domain by the focal adhesion kinase. (PubMed id 11369769)^{3, 4} Izaguirre G.... Haimovich B. (2001)
Calsarcins, a novel family of sarcomeric calcineurin-binding proteins. (PubMed id 11114196)^{3, 4} Frey N.... Olson E.N. (2000)
Myotilin, a novel sarcomeric protein with two Ig-like domains, is encoded by a candidate gene for limb-girdle muscular dystrophy. (PubMed id 10369880)^{3, 4} Salmikangas P....Carpen O. (1999)
Identification of the 70kD heat shock cognate protein (Hsc70) and alpha-actinin-1 as novel phosphotyrosine-containing proteins in T lymphocytes. (PubMed id 8713105)^{3, 4} Egerton M.... Simpson R.J. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 87	HGNC: 163	AceView: ACTN1	Ensembl:ENSG00000072110	euGenes: HUgn87
ECgene: ACTN1	H-InvDB: ACTN1

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for ACTN1
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for ACTN1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ACTN1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ACTN1		Antibodies for ACTN1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ACTN1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (ACTN1)
	Antibodies (ACTN1)
	Chimera RNAi (ACTN1)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for ACTN1

	Recombinant Proteins (alpha Actinin)
	Antibodies (alpha Actinin)

Search OriGene for ACTN1

Search Tocris compounds for ACTN1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for ACTN1

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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ACTN1 Gene at Home site.
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ACTN1 Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for ACTN1

Summaries
for ACTN1

Genomic Location
for ACTN1

Proteins
for ACTN1

Protein Domains/
Families
for ACTN1

Gene Function
for ACTN1

Pathways & Interactions
for ACTN1

Drugs & Compounds
for ACTN1

Transcripts
for ACTN1

Expression
for ACTN1

Orthologs
for ACTN1

Paralogs
for ACTN1

SNPs/Variants
for ACTN1

Disorders & Mutations
for ACTN1

Medical News
for ACTN1

Publications
for ACTN1

Search for ACTN1

Genome Databases showing ACTN1

Other Databases showing ACTN1

Specialized Databases showing ACTN1

Licensable Technologies
for ACTN1

Services
for ACTN1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ACTN1 Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor ACTN1

Summariesfor ACTN1

Genomic Locationfor ACTN1

Proteinsfor ACTN1

Protein Domains/Familiesfor ACTN1

Gene Functionfor ACTN1

Pathways & Interactionsfor ACTN1

Drugs & Compoundsfor ACTN1

Transcriptsfor ACTN1

Expression for ACTN1

Orthologsfor ACTN1

Paralogsfor ACTN1

SNPs/Variantsfor ACTN1

Disorders & Mutationsfor ACTN1

Medical Newsfor ACTN1

Publicationsfor ACTN1

Search for ACTN1

Genome Databases showing ACTN1

Other Databases showing ACTN1

Specialized Databases showing ACTN1

Licensable Technologiesfor ACTN1

Servicesfor ACTN1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ACTN1

Summaries
for ACTN1

Genomic Location
for ACTN1

Proteins
for ACTN1

Protein Domains/
Families
for ACTN1

Gene Function
for ACTN1

Pathways & Interactions
for ACTN1

Drugs & Compounds
for ACTN1

Transcripts
for ACTN1

Expression
for ACTN1

Orthologs
for ACTN1

Paralogs
for ACTN1

SNPs/Variants
for ACTN1

Disorders & Mutations
for ACTN1

Medical News
for ACTN1

Publications
for ACTN1

Licensable Technologies
for ACTN1

Services
for ACTN1