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ACTN1 Gene

protein-coding   GIFtS: 65

GC14M068410
actinin, alpha 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
FLJ40884 2
FLJ54432 2
Descriptions
Alpha-actinin cytoskeletal isoform 3
F-actin cross-linking protein 2, 3
Non-muscle alpha-actinin-1 3
actinin 1 smooth muscle 2
actinin, alpha 1 2
alpha-actinin 1 2
External Ids
HGNC: 1631
Entrez Gene: 872
UniProtKB: P128143
Ensembl: ENSG000000721107
Search outside databases for aliases for ACTN1 gene

Previous GC identifers: GC14M066846 GC14M063137 GC14M067330 GC14M067331

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ACTN1:
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of
cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an
actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the
cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is
involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle
isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the
myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform
and maps to the same site as the structurally similar erythroid beta spectrin gene. Three
transcript variants encoding different isoforms have been found for this gene. [provided by
RefSeq]

UniProtKB/Swiss-Prot: ACTN1_HUMAN, P12814
Function: F-actin cross-linking protein which is thought to anchor actin to a variety of
intracellular structures. This is a bundling protein

Gene Wiki entry for ACTN1 (Actinin%2C_alpha_1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the ACTN1 gene  

Entrez Gene cytogenetic band: 14q24.1-q24.2|14q24|14q22-q24   Ensembl cytogenetic band:  14q24.1   HGNC cytogenetic band: 14q24.1

ACTN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M068410:     (about GC identifiers)

Start:
68,410,793 bp from pter
End:
68,515,763 bp from pter
Size:
104,971 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000014.7  NT_026437.11  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ACTN1_HUMAN, P12814 (See protein sequence)
Recommended Name: Alpha-actinin-1  
Size: 892 amino acids; 103058 Da
Subunit: Homodimer; antiparallel. Interacts with DDN, MYOZ2, PDLIM2, TTID and LPP
Subcellular location: Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z-disk.
Note=Colocalizes with MYOZ2 and PPP3CA at the Z-line of heart and skeletal muscle
PDB structure from and Proteopedia :
2EYI (3D)    2EYN (3D)    
Secondary accessions: Q9BTN1

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (3 alternative transcripts): 
    NP_001093.1  NP_001123476.1  NP_001123477.1  


    ENSEMBL proteins: 
    ENSP00000193403 ENSP00000377941 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (alpha Actinin)
    Human Recombinant Proteins from Abnova (ACTN1)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    5 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005730 nucleolus IDA18029348
    GO:0005737 cytoplasm IEA--
    GO:0005856 cytoskeleton IEA--
    GO:0005925 focal adhesion IMP16807302
    GO:0031143 pseudopodium TAS1629252
    About this table

    Antibodies for ACTN1: 
    Browse Antibodies Central at Invitrogen
    Millipore Mono- and Polyclonal Antibodies for the study of ACTN1
    Sigma-Aldrich Antibody Arrays and Antibodies for ACTN1
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for ACTN1 
    Antibodies from Abcam (alpha Actinin), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (ACTN1)
    Novus Biologicals Antibodies for ACTN1

    Assays for ACTN1: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    5/10 InterPro domains/families (see all 10 ):
     IPR014837 EF-hand_Ca_insen
     IPR018247 EF_HAND_1
     IPR002017 Spectrin_repeat
     IPR001715 Calponin_act_bd
     IPR011992 EF-Hand_type


       GeneDecks  ACTN1 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry P12814

    ProtoNet protein and cluster: P12814

    3 Blocks protein families:
    IPB001589 Actin-binding
    IPB001715 Calponin-like actin-binding
    IPB002017 Spectrin repeat


    UniProtKB/Swiss-Prot: ACTN1_HUMAN, P12814
    Similarity: Belongs to the alpha-actinin family
    Similarity: Contains 1 actin-binding domain
    Similarity: Contains 2 CH (calponin-homology) domains
    Similarity: Contains 2 EF-hand domains
    Similarity: Contains 4 spectrin repeats

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (ACTN1)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (ACTN1)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001130004

                  Applied Biosystems Silencer® siRNAs for ACTN1

                  Sigma-Aldrich siRNA for ACTN1  
                         Sigma-Aldrich shRNA Panels and shRNA for ACTN1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for ACTN1
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001102
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001102
                                     untagged cDNA clones in CMV expression vector (see all 4): NM_001102 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_001130004

    UniProtKB/Swiss-Prot: ACTN1_HUMAN, P12814
    Function: F-actin cross-linking protein which is thought to anchor actin to a variety of
    intracellular structures. This is a bundling protein

    Genatlas biochemistry entry for ACTN1:
    actinin,alpha 1,actin filament cross-linking,calcium sensitive,cytoskeletal type,expressed in non
    muscle cells

    5 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779 actin binding IEA--
    GO:0005178 integrin binding IDA7983147
    GO:0005509 calcium ion binding IEA--
    GO:0005515 protein binding IPI10793131
    GO:0017166 vinculin binding IPI15988023
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    1 Invitrogen iPath™ Online BioAtlas - Pathway for ACTN1 (Maps provided by GeneGo):
     Putative integrins pathway. Part 1

       GeneDecks  ACTN1 for the pathways selected above  
    About GeneDecksing

    5/6 Millipore Pathways for ACTN1 (see all 6 )
     Cell adhesion Integrin-mediated cell adhesion and migration
     Cytoskeleton remodeling Integrin outside-in signaling
     Cytoskeleton remodeling Fibronectin-binding integrins in cell motility
     Selected targets of GCR-alpha
     Cell adhesion Endothelial cell contacts by junctional mechanisms

       GeneDecks  ACTN1 for the pathways selected above  
    About GeneDecksing

    5 Sigma-Aldrich "Your Favorite Gene" Pathways for  ACTN1  (Your Favorite Gene powered by Ingenuity) 
     Germ Cell-Sertoli Cell Junction Signaling
     Integrin Signaling
     Actin Cytoskeleton Signaling
     Leukocyte Extravasation Signaling
     VEGF Signaling

       GeneDecks  ACTN1 for the pathways selected above  
    About GeneDecksing

    5/6 Kegg Pathways  (Kegg details for ACTN1) (see all 6 ):
     hsa04510 Focal adhesion
     hsa04520 Adherens junction
     hsa04530 Tight junction
     hsa04670 Leukocyte transendothelial migration
     hsa04810 Regulation of actin cytoskeleton

       GeneDecks  ACTN1 for the pathways selected above  
    About GeneDecksing
     Gene Network CentralTM Interacting Genes and Proteins Network for  ACTN1 


    5/92 Interacting proteins for ACTN1 (P128141, 2 ENSP000001934033) via UniProtKB, MINT, and/or STRING (see all 92 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYOZ1Q9NP982, ENSP000003522723MINT-68434 STRING (score=.906)
    SRCP129311, 2EBI-351710, EBI-621482 MINT-6795322 EBI-351710, EBI-621482 MINT-6795322
    PTPN1P180311EBI-351710, EBI-968788
    SRCP129311, 2EBI-351710, EBI-621482 MINT-6795322 EBI-351710, EBI-621482 MINT-6795322
    ATXN2Q997002MINT-2856533 MINT-2856514
    About this table

    3 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0042981 regulation of apoptosis NAS16807302
    GO:0048041 focal adhesion formation IMP16807302
    GO:0051271 negative regulation of cell motion IMP7983147
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for ACTN1
    1 Novoseek chemical compound relationship for ACTN1 gene
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 11.53 4 17898132 (2), 11802708 (1), 16547650 (1)
    About this table


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (ACTN1)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (ACTN1)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001130004

                  Sigma-Aldrich siRNA for ACTN1  
                         Sigma-Aldrich shRNA Panels and shRNA for ACTN1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_001102  NM_001130004  NM_001130005  

    REFSEQ mRNAs for ACTN1 gene (3 alternative transcripts): 

    NM_001102.3   NM_001130004.1   NM_001130005.1   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_001102  NM_001130004  NM_001130005  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001102
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001102
                                     untagged cDNA clones in CMV expression vector (see all 4): NM_001102 

    Additional cDNA sequence: 

    AJ844628.2 AK022224.1 AK098203.1 AK124378.1 AK225782.1 AK294317.1 AK295099.1 AK298496.1 
    AK299362.1 BC003576.1 BC004984.1 BC015766.1 BC127124.1 BT007207.1 BX248020.1 BX641076.1 
    CR609497.1 CR620987.1 DQ496098.1 EU716325.1 FJ410030.1 M95178.1 X15804.1 X55187.1 

    24/55 DOTS entries (see all 55 ):

    DT.100771871  DT.100887428  DT.100766388  DT.91823921  DT.91782289  DT.95125704  DT.87017777  DT.120785717 
    DT.100887439  DT.91782278  DT.91679968  DT.102839930  DT.100887429  DT.100887448  DT.95287775  DT.100887434 
    DT.120785745  DT.100887445  DT.95276950  DT.91971379  DT.100660649  DT.100887419  DT.75110244  DT.91818067 

    24/699 AceView cDNA sequences (see all 699 ):

    AU124830 BE312967 BM762824 AW084267 BC003576 BU621901 BQ010008 AI139065 
    W51764 BQ017489 AW071868 BM709038 BQ649552 AA418035 BM695526 BM915810 
    BM802096 BE701572 AI082078 CF890756 BU520922 BM676908 CD365004 BQ021240 

    highest scoring ESTs for ACTN1:

    X15804 M95178 AK098203 AU098889 AU121135 AU121719 AU128840 AU130638 AU132715 AU280791 

    Unigene Cluster for ACTN1:

    Actinin, alpha 1
    Hs.509765  [show with all ESTs]
    Unigene Representative Sequence: BX641076


    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for ACTN1 (see all 12 )

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b ^
    SP1:              -     -           -                                                                             -                                             
    SP2:                                                                                                              -                                             
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:              -     -     -     -     -                                                                                                                     

    ExUns: 19a · 19b ^ 20a · 20b ^ 21a · 21b ^ 22 ^ 23 ^ 24a · 24b
    SP1:  -                 -                 -                     
    SP2:  -                 -     -     -                           
    SP3:                                                            
    SP4:  -                 -     -     -     -                     
    SP5:                                                            

    About this scheme

    ECgene alternative splicing isoforms for ACTN1

    2 Ensembl transcripts including schematic representations:
    ENST00000193403  ENST00000394419  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    ACTN1 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for ACTN1

    1 / 2 / 3

    10 probe-sets matching ACTN1 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    39330_s_at2, 3 U95-A 1 1.00 1.00 0.98 0.90 M95178 1.00 0.90 0.95 1

    39329_at2, 3 U95-A 1 1.00 1.00 0.98 1.10 X15804 1.00 1.00 1.00 1

    208637_x_at2, 3 U133-A 1 1.00 1.00 -- -- BC003576 0.80 1.00 0.91 1

    208636_at2, 3 U133-A 1 1.00 1.00 -- -- AI082078 0.60 1.00 0.82 1

    211160_x_at2, 3 U133-A 2 1.00 0.95 -- -- M95178 1.00 0.90 0.95 1

    200943_at2 U133-A 7 0.91 0.19 -- -- -- -- -- -- --

    208637_x_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    208636_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    211160_x_at2 U133Plus2 2 1.00 0.95 -- -- -- -- -- -- --

    200943_at2 U133Plus2 7 0.91 0.19 -- -- -- -- -- -- --
    GeneDecks  ACTN1 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: TCCTTCTCCA

    SOURCE GeneReport for Unigene cluster: Hs.509765

    Expression variation in blood from EXPOLDB for ACTN1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for ACTN1 gene from 5/11 species (see all 11 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    ACTN11   -- actinin, alpha 1 94.06(n)
    99.33(a)
    480369  XM_848010.1  XP_853103.1 
    chimpanzee
    (Pan troglodytes)
    ACTN11   -- actinin, alpha 1 98.65(n)
    98.88(a)
    452993  XM_001139826.1  XP_001139826.1 
    cow
    (Bos taurus)
    ACTN11   -- actinin, alpha 1 94.13(n)
    99.44(a)
    524770  NM_001035351.1  NP_001030428.1 
    rat
    (Rattus norvegicus)
    Actn11   -- actinin, alpha 1 91.7(n)
    99.33(a)
    81634  NM_031005.2  NP_112267.1 
    mouse
    (Mus musculus)
    Actn11, 5 12 (35.00 cM)5
    actinin, alpha 11, 5 91.52(n)1
    99.22(a)1
    1097111  NM_134156.11  NP_598917.11 
     AI1953925  AK0140735  (see all 18)
    About this table        Species with no ortholog for ACTN1

    ENSEMBL Gene Tree for ACTN1
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for ACTN1 gene
    ACTN22  ACTN42  ACTN32  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/650 NCBI SNPs in ACTN1 are shown (see all 650 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 272)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 14 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs1814541,2
    A,C,F,H,O68410295(+) TGTTCA/CCTGCA 1 -- ng5112Minor allele frequency- N:0.00EU EA WA NA 1054
    rs1814551,2
    A,C,F,H68410322(+) TGGGGT/GGAATG 1 -- ng514Minor allele frequency- G:0.30EU EA WA 420
    rs10074071,2
    A,C,F,H68516713(-) GCCTCA/GGTTTC 1 -- ng31 tfbs312Minor allele frequency- G:0.36EA NA MN EU WA 1086
    rs14750341,2
    C,F,H68410513(-) CTACTC/ACTAAT 1 -- ng518Minor allele frequency- A:0.15EU EA WA 840
    rs1814561,2
    A,C,F68410352(+) TGGTGC/TCGTGG 1 -- ng513Minor allele frequency- T:0.38NA 142
    rs38093931,2
    C,F,H68515866(+) CAGGCC/AGAGTT 1 -- ng316Minor allele frequency- A:0.11EU EA WA NA 596
    --
    rs115577691,2
    C,F68411406(-) CCTACA/TCCGGC 3 T/S mis1 ese34Minor allele frequency- T:0.01EU EA WA 420
    --
    rs10542351,2
    H68415491(-) TCATCA/TGCTTG 2 S/C mis13Minor allele frequency- T:0.00MN EU WA 408
    rs122371,2
    F68410953(+) AGATAG/TAAGAA 3 -- ut311Minor allele frequency- T:0.07MN 184
    rs10549921,2
    F68410857(-) ATTGGG/TGCATG 3 -- ut311Minor allele frequency- T:0.14MN 184
    About this table

    HapMap Linkage Disequilibrium images for ACTN1 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 102575

    1 Novoseek disease relationship for ACTN1 gene

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0.00 5 18320066 (3)
    About this table

    1 PharmGKB disease relationship for ACTN1 gene
    Disease PharmGKB Relations PubMed IDs for articles supporting these relationships
    Leukemia, Lymphocytic, Acute, L1FA  GN  12086872
    About this table

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/120 PubMed articles for ACTN1 gene (see all 120 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 87 HGNC: 163 AceView: ACTN1 Ensembl:ENSG00000072110 euGenes: HUgn87
    ECgene: ACTN1 H-InvDB: ACTN1
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for ACTN1:
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     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for ACTN1

    GeneCards Homepage    -    Last full update: 1 Jul 2009        Incremental update: 13 Oct 2009

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