ACTN1 Gene
protein-coding GIFtS : 66
GCID: GC14 M069341
actinin, alpha 1
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Aliasesfor ACTN1 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Actinin, Alpha 1 1 2 Alpha-Actinin Cytoskeletal Isoform2 3 Non-Muscle Alpha-Actinin-12 3 F-Actin Cross-Linking Protein2 3 Actinin 1 Smooth Muscle2 Alpha-Actinin-11
Export aliases for ACTN1 gene to outside databases Previous GC identifers: GC14M066846 GC14M063137 GC14M067330 GC14M067331 GC14M068410 GC14M049510
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Summariesfor ACTN1 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for ACTN1 : Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: ACTN1_HUMAN, P12814 Function : F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. Thisis a bundling protein Gene Wiki entry for ACTN1 (Actinin, alpha 1)
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Genomic Viewsfor ACTN1 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000014.8 NC_018925.1 NT_026437.12 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the ACTN1 gene promoter: GR AhR Elk-1 Sp1 MyoD Arnt CREB c-Myb GR-alpha Other transcription factors Search SABiosciences Chromatin IP Primers for ACTN1 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat ACTN1
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 14q24|14q22-q24 Ensembl cytogenetic band: 14q24.1 HGNC cytogenetic band: 14q24.1 ACTN1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 14 GeneLoc Exon Structure
GeneLoc location for GC14M069341: view genomic region
(about GC identifiers )
Start:
69,340,840 bp from pter
End:
69,446,157 bp from pter
Size:
105,318 bases
Orientation:
minus strand
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Proteinsfor ACTN1 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: ACTN1_HUMAN, P12814 (See
protein sequence )Recommended Name: Alpha-actinin-1 Size : 892 amino acids; 103058 Da
Subunit : Homodimer; antiparallel. Interacts with DDN, MYOZ2, PDLIM2, TTID and LPP. Interacts with PSD (By similarity)
Subcellular location : Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line. Cell membrane (By similarity).Cell projection, ruffle (By similarity). Note=Colocalizes with MYOZ2 and PPP3CA at the Z-line of heart and skeletal muscle. Colocalizes with PSD in membrane ruffles and central reticular structures (By similarity)
2 PDB 3D structures from and Proteopedia for ACTN1 :2EYI (3D)
  2EYN (3D)
 
Secondary accessions : B3V8S3 B4DHH3 Q1HE25 Q9BTN1Alternative splicing : 3 isoforms : P12814-1 P12814-2 P12814-3 Explore the universe of human proteins at neXtProt for ACTN1: NX_P12814 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_P12814 ACTN1 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins (3 alternative transcripts):
NP_001093.1 NP_001123476.1 NP_001123477.1 ENSEMBL proteins: ENSP00000193403 ENSP00000377941 ENSP00000414272 ENSP00000366035 ENSP00000452254 ENSP00000439828 ENSP00000444422 ENSP00000450625 ENSP00000450903 ENSP00000450764 ENSP00000450925 ENSP00000450618 ENSP00000452423 ENSP00000451086 Reactome Protein details: P12814 Human Recombinant Protein Products: Gene Ontology (GO): 5/17 cellular component terms (GO ID links to tree view) (see all 17 ): About this table
ACTN1 for ontologies About GeneDecksing ACTN1 Antibody Products: Assay Products for ACTN1:
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Protein
Domains / Familiesfor ACTN1 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
ACTN1 for domains About GeneDecksing 5/9 InterPro domains/families (see all 9 ):
Graphical View of Domain Structure for InterPro Entry P12814 ProtoNet protein and cluster: P12814
3 Blocks protein families : IPB001589 Actin-binding IPB001715 Calponin-like actin-binding IPB002017 Spectrin repeat UniProtKB/Swiss-Prot: ACTN1_HUMAN, P12814 Similarity : Belongs to the alpha-actinin familySimilarity : Contains 1 actin-binding domainSimilarity : Contains 2 CH (calponin-homology) domainsSimilarity : Contains 2 EF-hand domainsSimilarity : Contains 4 spectrin repeats
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Functionfor ACTN1 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: ACTN1_HUMAN, P12814 Function : F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. Thisis a bundling protein
Genatlas biochemistry entry for ACTN1 : actinin,alpha 1,actin filament cross-linking,calcium sensitive,cytoskeletal type,expressed in non muscle cells Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ACTN1 (see all 5 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ACTN1 (see all 4 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 3 ): ACTN1 (NM_001130004 ) Sino Biological Human cDNA Clone for ACTN1 DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ACTN1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ACTN1
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACTN1
Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8 ): About this table
ACTN1 for ontologies About GeneDecksing 1 GenomeRNAi human phenotype for ACTN1 :Animal Models: 1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Actn1) :
ACTN1 for phenotypes About GeneDecksing
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Pathways & Interactionsfor ACTN1 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways  - 5/25 super-pathways (see all 25 ) About this table See pathways by source Super-pathway contained gene-specific pathways 1 Cell adhesion_Integrin-mediated cell adhesion and migration 2 Sertoli-Sertoli Cell Junction Dynamics 3 Platelet activation, signaling and aggregation 4 Platelet degranulation 5 Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
Pathway sources See GeneCards unified pathways Show all pathways 5/6 EMD Millipore Pathways for ACTN1 (see all 6 )5/6 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ACTN1 (see all 6 )1
Cell Signaling Technology (CST) Pathway for ACTN1 5/6 GeneGo (Thomson Reuters) Pathways for ACTN1 (see all 6 )5/6 BioSystems Pathways for ACTN1 (see all 6 ) 5/9
Reactome Pathways for ACTN1 (see all 9 )5/8
Kegg Pathways (Kegg details for ACTN1) (see all 8 ):
ACTN1 for pathways About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ACTN1 STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/210 Interacting proteins for ACTN1 (P12814 1 , 2 , 3 ENSP00000377941 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 210 )About this table Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9 ): About this table
ACTN1 for ontologies About GeneDecksing
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Drugs & Compoundsfor ACTN1 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section
ACTN1 for compounds About GeneDecksing Browse Tocris compounds for ACTN1 1 Novoseek chemical compound relationship for ACTN1 gene About this table
Search CenterWatch for drugs/clinical trials and news about ACTN1
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Transcriptsfor ACTN1 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for ACTN1 gene (3 alternative transcripts): NM_001102.3 NM_001130004.1 NM_001130005.1 Unigene Cluster for ACTN1:
Actinin, alpha 1 Hs.509765 [show with all ESTs ] Unigene Representative Sequence: BX641076 18/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21 ): ENST00000193403 (uc010ttb.2 uc001xkm.3 uc001xkl.3 uc001xkn.3 )ENST00000556083 (uc001xkk.3 ) ENST00000553882 ENST00000394419 (uc010ttc.2 )ENST00000438964 ENST00000376839 ENST00000555075 ENST00000538545 (uc001xko.1 uc010ttd.1 )ENST00000544964 ENST00000553290 ENST00000556432 ENST00000556343 ENST00000555616 ENST00000556433 ENST00000554508 ENST00000554158 ENST00000553370 ENST00000553779 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ACTN1 (see all 5 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ACTN1 (see all 4 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 3 ): ACTN1 (NM_001130004 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ACTN1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ACTN1
Additional cDNA sequence: AJ844628.2 AK022224.1 AK098203.1 AK124378.1 AK225782.1 AK294317.1 AK295099.1 AK298496.1 AK299362.1 BC003576.1 BC004984.1 BC015766.1 BC127124.1 BT007207.1 BX248020.1 BX641076.1 DQ496098.1 EU716325.1 FJ410030.1 M95178.1 X15804.1 X55187.1
24/56 DOTS entries (see all 56 ): DT.100771871 DT.100887428
DT.100766388 DT.91823921 DT.91782289 DT.95125704 DT.87017777 DT.120785717 DT.100887439 DT.91782278 DT.102839930 DT.91679968 DT.100887429 DT.100887448 DT.95287775 DT.100887434 DT.120785745 DT.100887445 DT.95276950 DT.91971379 DT.100660649 DT.100887419 DT.75110244 DT.75187470 24/699 AceView cDNA sequences (see all 699 ):
BE701559 CF126020 AI783804 BU520922 CD722546 BX504054 BI768544 BQ425462 BM670895 BU541027 BE729043 BU543768 BE259786 AI302243 BM989999 BQ648953 BM693833 CF125358 BM824217 W51764 BQ010008 AI298860 NM_001102 BF823723 GeneLoc Exon Structure 5/12 Alternative Splicing Database (ASD) splice patterns (SP) for ACTN1 (see all 12 ) About this scheme ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b ^ SP1 :     -   -     -                           -                 SP2 :                                     -                 SP3 :                                                     SP4 :                                                     SP5 :     -   -   -   -   -                                        
ExUns: 19a · 19b ^ 20a · 20b ^ 21a · 21b ^ 22 ^ 23 ^ 24a · 24b SP1 : -       -       -         SP2 : -       -   -   -           SP3 :                     SP4 : -       -   -   -   -         SP5 :                    
ECgene alternative splicing isoforms for ACTN1
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Expression for ACTN1 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section ACTN1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TCCTTCTCCA
About this image ACTN1 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See ACTN1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for ACTN1 SOURCE GeneReport for Unigene cluster: Hs.509765 SABiosciences Expression via Pathway-Focused PCR Arrays including ACTN1 : Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for ACTN1Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat ACTN1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat ACTN1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat ACTN1 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACTN1
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Orthologsfor ACTN1 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for ACTN1 gene from 6/25 species (see all 25 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
chicken (Gallus gallus)
Aves
ACTN11
actinin, alpha 1
85.01(n) 97.51(a)
 
373918 NM_204127.1 NP_989458.1
lizard (Anolis carolinensis)
Reptilia
ACTN16
--
97(a)
1 ↔ 1
GL343272.1(184321-240182)
African clawed frog (Xenopus laevis)
Amphibia
Xl.183872
Xenopus laevis mRNA similar to actinin, alpha 1 (cDNA more
81.12(n)
 
BC043995.1
zebrafish (Danio rerio)
Actinopterygii
actn11
actinin, alpha 1
81.72(n) 93.81(a)
 
560400 NM_001168286.1 NP_001161758.1
fruit fly (Drosophila melanogaster)
Insecta
Actn1 , 3
cytoskeletal anchoring actin binding3 alpha actinin1
68(a) 3 70.79(n) 1 70.37(a) 1
 
31166 1 NM_058137.4 1 NP_477485.1 1
worm (Caenorhabditis elegans)
Secernentea
atn-11
Protein ATN-1
59.47(n) 62.67(a)
 
179709 NM_073726.4 NP_506127.1
ENSEMBL Gene Tree for ACTN1 (if available)TreeFam Gene Tree for ACTN1 (if available)
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Paralogsfor ACTN1 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for ACTN1 gene ACTN4 2 SPTBN2 2 SPTA1 2 SYNE2 2 SPTBN4 2 SPTBN1 2 SPTB 2 SPTBN5 2 ACTN2 2 SPTAN1 2 SYNE1 2 CLMN 2 18/32 SIMAP similar genes for ACTN1 using alignment to 14 protein entries: ACTN1_HUMAN (see all proteins )
(see all similar genes ):MLL-ACTN4 ACTN4 ACTN2 ACTN3 UTRN DMD CLMN EHBP1L1 MICAL3 PLEC MACF1 DST HSpTB1 DIXDC1 NAV3 ACF7 FLNA SMTNL1
ACTN1 for paralogs About GeneDecksing 2 Pseudogenes.org Pseudogenes for ACTN1 PGOHUM00000259405 PGOHUM00000244676
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Genomic Variantsfor ACTN1 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 14 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for ACTN1 (69340840 - 69446157 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for ACTN1: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing ACTN1
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Disorders
/ Diseasesfor ACTN1 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
ACTN1 for disorders About GeneDecksing
OMIM gene information: 102575
OMIM disorders : --20/29 diseases for ACTN1 (see all 29 ): About MalaCards limb-girdle muscular dystrophy soft tissue sarcoma hypertrophic cardiomyopathy familial hypertrophic cardiomyopathy muscular dystrophy sickle cell anemia systemic lupus erythematosus lupus erythematosus macular degeneration dilated cardiomyopathy cardiomyopathy lipoma wilms tumor hepatitis c anemia lung adenocarcinoma sarcoma hepatocellular carcinoma endometriosis colon cancer 1 Novoseek disease relationship for ACTN1 gene About this table
Disease
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
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Human Genome Epidemiology (HuGE) Navigator: ACTN1 (1 document)Export disorders for ACTN1 gene to outside databases
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Publicationsfor ACTN1 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for ACTN1 gene, integrated from 9 sources (see all 165 ): (articles sorted by number of sources associating them with ACTN1) Utopia : connect your pdf to the dynamic world of online information
Cloning and chromosomal localization of the human cytoskeletal alpha- actinin gene reveals linkage to the beta-spectrin gene. (PubMed id 2349951) 1 , 2 , 3 Youssoufian H.... Kwiatkowski D.J. (1990) Postsynaptic recruitment of Dendrin depends on both dendritic mRNA transport and synaptic anchoring. (PubMed id 16464232) 1 , 2 , 9 Kremerskothen J.... Barnekow A. (2006) Alternative splicing in colon, bladder, and prostate cancer identified by exon array analysis. (PubMed id 18353764) 1 , 2 Thorsen K....Orntoft T.F. (2008) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801) 1 , 2 Gevaert K.... Vandekerckhove J. (2003) The lipoma preferred partner LPP interacts with alpha-actinin. (PubMed id 12615977) 1 , 2 Li B.... Trueb B. (2003) The cytoskeletal/non-muscle isoform of alpha-actinin is phosphorylated on its actin-binding domain by the focal adhesion kinase. (PubMed id 11369769) 1 , 2 Izaguirre G.... Haimovich B. (2001) Calsarcins, a novel family of sarcomeric calcineurin-binding proteins. (PubMed id 11114196) 1 , 2 Frey N.... Olson E.N. (2000) Myotilin, a novel sarcomeric protein with two Ig-like domains, is encoded by a candidate gene for limb-girdle muscular dystrophy. (PubMed id 10369880) 1 , 2 Salmikangas P....Carpen O. (1999)
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External Searches for ACTN1 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing ACTN1 gene
(According to
Entrez Gene ,
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AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
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Other Databases showing ACTN1 gene
(According to HUGE )
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Specialized Databases showing ACTN1 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for ACTN1 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for ACTN1 gene: Search GeneIP for patents involving ACTN1 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor ACTN1 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
OriGene Antibodies for ACTN1 OriGene shRNA RFP for ACTN1 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for ACTN1 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for ACTN1 OriGene Protein Over-expression Lysate for ACTN1 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for ACTN1 OriGene 3'-UTR Clone for ACTN1 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ACTN1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ACTN1 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for ACTN1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ACTN1 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing ACTN1 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat ACTN1 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat ACTN1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat ACTN1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat ACTN1
Antibodies & Assays for ACTN1  
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ACTN1 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACTN1
ThermoFisher Antibodies for ACTN1
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ACTN1
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