ACTL9 Gene
protein-coding GIFtS: 40
GCID: GC19M008807
|
|
actin-like 9
| |
Aliases
for ACTL9 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Actin-Like 91 2 | | MGC334071 | | Actin-Like Protein 92 | | ACTL7C3 |
Export aliases for ACTL9 gene to outside databasesPrevious GC identifers: GC19M008669 GC19M008423 |
Summaries
for ACTL9 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for ACTL9 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011295.11
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for ACTL9
Other transcription factors
Search SABiosciences Chromatin IP Primers for ACTL9
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ACTL9 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.2 Ensembl cytogenetic band: 19p13.2 HGNC cytogenetic band: 19p13.2ACTL9 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M008807: view genomic region
(about GC identifiers)
Start:
|
8,807,751 bp from pter |
End:
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8,809,172 bp from pter |
Size:
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1,422 bases |
Orientation:
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minus strand |
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Proteins
for ACTL9 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ACTL9_HUMAN, Q8TC94 (See
protein sequence)Recommended Name: Actin-like protein 9 Size: 416 amino acids; 45627 Da
Subcellular location: Cytoplasm, cytoskeleton (By similarity)
Secondary accessions: A8K893 Q6X960Explore the universe of human proteins at neXtProt for ACTL9: NX_Q8TC94
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8TC94
ACTL9 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_848620.2
ENSEMBL proteins: ENSP00000316674
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
ACTL9 for ontologies About GeneDecksing
ACTL9 Antibody Products:
Assay Products for ACTL9: |
Protein
Domains /
Families
for ACTL9 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ACTL9 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8TC94ProtoNet protein and cluster: Q8TC94 2 Blocks protein families: IPB002052 N-6 Adenine-specific DNA methylase IPB004000 Actin/actin-like
UniProtKB/Swiss-Prot: ACTL9_HUMAN, Q8TC94Similarity: Belongs to the actin family |
Function
for ACTL9 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ACTL9 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ACTL9
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ACTL9 (NM_178525) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ACTL9 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACTL9 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACTL9 |
2 GenomeRNAi human phenotypes for ACTL9:
|
Pathways & Interactions
for ACTL9 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ACTL9
|
Drugs & Compounds
for ACTL9 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ACTL9
Search CenterWatch for drugs/clinical trials and news about ACTL9
|
Transcripts
for ACTL9 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ACTL9 gene: NM_178525.3 Unigene Cluster for ACTL9: Actin-like 9 Hs.209206 [show with all ESTs]Unigene Representative Sequence: BC0457521 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000324436(uc002mkl.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ACTL9 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ACTL9
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ACTL9 (NM_178525) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ACTL9 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACTL9 |
Additional cDNA sequence: AK292258.1 AY248901.1 BC024028.2 BC045752.1 1 DOTS entry: DT.91666235 19 AceView cDNA sequences: NM_178525 BX281548 BI826044 BC045752 BI826167 BI520532 BQ109388 AI028227 AY248901 CD300446 BC024028 BG720184 BI831678 BI460464 BI831457 AI798166 BI520606 BI461609 AI968058
GeneLoc Exon Structure
|
Expression
for ACTL9 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ACTL9 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCAAGCAGA
About this image
See ACTL9 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ACTL9
SOURCE GeneReport for Unigene cluster: Hs.209206
SABiosciences Custom PCR Arrays for ACTL9
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ACTL9
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ACTL9 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ACTL9 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ACTL9 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACTL9 |
Orthologs
for ACTL9 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for ACTL9 gene from 4/14 species (see all 14) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
ACTL91 |
actin-like 9 |
56.16(n)
43.56(a) |
|
428337 XM_425897.2 XP_425897.3 |
lizard
(Anolis carolinensis) |
Reptilia |
ACTL96 |
-- |
54(a) |
1 ↔ 1 |
AAWZ02038656(5113-6469) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
ATARP76 |
actin-related protein 7 |
30(a) |
possible ortholog |
3(22474074-22476445) |
rice
(Oryza sativa) |
Liliopsida |
-- |
actin, putative, expressed |
26(a) |
possible ortholog |
3(32437237-32441779) |
ENSEMBL Gene Tree for ACTL9 (if available)
TreeFam Gene Tree for ACTL9 (if available) |
Paralogs
for ACTL9 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ACTL9 gene
- ACTG22 ACTA22 ACTB2 ACTRT22 ACTR1A2 ACTC12 ACTRT12 ACTG12
- ACTL7A2 ACTBL22 ACTL7B2 ACTR1B2 ACTA12 ACTRT32
18/21 SIMAP similar genes for ACTL9 using alignment to 1 protein entry: ACTL9_HUMAN(see all similar genes):ACT ACTB ACTL7A PS1TP5BP1 ACTG1 POTEKP
ACTA2 ACTBL2 ACTC1 ACTG2 ACTRT3 ACTR1A
ACTRT1 ACTRT2 ACTR2 ACTR1B ACTL7B ACTL10
ACTL9 for paralogs About GeneDecksing
|
Genomic Variants
for ACTL9 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ACTL9 (8807751 - 8809172 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ACTL9
1 CNV: 5079 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ACTL9 |
|
Disorders
/ Diseases
for ACTL9 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for ACTL9 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ACTL9 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ACTL9) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Meta-analysis of genome-wide association studies ident ifies three new risk loci for atopic dermatitis. (PubMed id 22197932)1 Paternoster L....Weidinger S. (2012)
- The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
|
External Searches for ACTL9 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ACTL9 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ACTL9 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ACTL9 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ACTL9 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ACTL9 gene:
Search GeneIP for patents involving ACTL9
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ACTL9 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ACTL9 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ACTL9 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ACTL9 | | | OriGene Protein Over-expression Lysate for ACTL9 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ACTL9 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ACTL9 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ACTL9 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
 |
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 | | | ACTL9 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACTL9 |
|  |  |  | | | | Search ThermoFisher Antibodies for ACTL9 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACTL9 |
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