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Aliases for ACTL9 Gene

Aliases for ACTL9 Gene

  • Actin Like 9 2 3 5
  • Testicular Tissue Protein Li 15 3
  • Testicular Tissue Protein Li 9 3
  • Actin-Like Protein 9 3
  • ACTL7C 4
  • HSD21 3

External Ids for ACTL9 Gene

Previous GeneCards Identifiers for ACTL9 Gene

  • GC19M008807
  • GC19M008423

Summaries for ACTL9 Gene

GeneCards Summary for ACTL9 Gene

ACTL9 (Actin Like 9) is a Protein Coding gene. An important paralog of this gene is ACTL7A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACTL9 Gene

Genomics for ACTL9 Gene

Regulatory Elements for ACTL9 Gene

Enhancers for ACTL9 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F008878 0.4 FANTOM5 14.9 -179.6 -179644 0.2 SUZ12 NFYA HCFC1 SIX5 ELF1 ZBTB40 GABPA MBD2 ZNF366 NFYB ACTL9 ZNF558 ZNF561 FBXL12 MUC16 ZNF177 OR7G1 PIR31457 GC19P008942
GH19F008663 0.5 Ensembl ENCODE 12.9 +34.4 34428 1.2 BCOR ATF1 ETV1 ZNF580 ZMYM3 KDM1A CREM ACTL9 ADAMTS10 ZNF559 ENSG00000261866 GC19P008677 LINC01862
GH19F008665 0.6 Ensembl ENCODE 12.9 +32.2 32240 1.6 BCOR ZNF121 SMARCA5 ZMYM3 ACTL9 ADAMTS10 GC19P008677 ENSG00000261866 LINC01862
GH19F008637 1 FANTOM5 Ensembl ENCODE 11.6 +59.2 59230 3.6 ELF3 ARID4B THRB ZNF48 RARA YY1 ZNF121 SLC30A9 CREM THAP11 MYO1F ADAMTS10 ACTL9 PRAM1 LOC100128428 LINC01862 GC19P008677 ENSG00000261866
GH19F008633 0.2 Ensembl 11.6 +65.1 65130 0.2 ESRRA ZNF366 NR2F1 ADAMTS10 ACTL9 MYO1F LINC01862 GC19P008677 ENSG00000261866
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ACTL9 on UCSC Golden Path with GeneCards custom track

Genomic Location for ACTL9 Gene

8,697,397 bp from pter
8,698,830 bp from pter
1,434 bases
Minus strand

Genomic View for ACTL9 Gene

Genes around ACTL9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACTL9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACTL9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACTL9 Gene

Proteins for ACTL9 Gene

  • Protein details for ACTL9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Actin-like protein 9
    Protein Accession:
    Secondary Accessions:
    • A8K893
    • Q6X960

    Protein attributes for ACTL9 Gene

    416 amino acids
    Molecular mass:
    45627 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ACTL9 Gene

Post-translational modifications for ACTL9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ACTL9 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ACTL9 Gene

Domains & Families for ACTL9 Gene

Protein Domains for ACTL9 Gene

Suggested Antigen Peptide Sequences for ACTL9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the actin family.
  • Belongs to the actin family.
genes like me logo Genes that share domains with ACTL9: view

No data available for Gene Families for ACTL9 Gene

Function for ACTL9 Gene

genes like me logo Genes that share phenotypes with ACTL9: view

Animal Model Products

miRNA for ACTL9 Gene

miRTarBase miRNAs that target ACTL9

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ACTL9 Gene

Localization for ACTL9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACTL9 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

Jensen Localization Image for ACTL9 Gene COMPARTMENTS Subcellular localization image for ACTL9 gene
Compartment Confidence
cytoskeleton 3
cytosol 3
nucleus 3
peroxisome 1

Gene Ontology (GO) - Cellular Components for ACTL9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with ACTL9: view

Pathways & Interactions for ACTL9 Gene

SuperPathways for ACTL9 Gene

No Data Available

Interacting Proteins for ACTL9 Gene

Gene Ontology (GO) - Biological Process for ACTL9 Gene


No data available for Pathways by source and SIGNOR curated interactions for ACTL9 Gene

Transcripts for ACTL9 Gene

mRNA/cDNA for ACTL9 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(19) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ACTL9 Gene

Actin-like 9:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ACTL9 Gene

No ASD Table

Relevant External Links for ACTL9 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ACTL9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ACTL9 Gene

mRNA differential expression in normal tissues according to GTEx for ACTL9 Gene

This gene is overexpressed in Testis (x52.6).

Protein differential expression in normal tissues from HIPED for ACTL9 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ACTL9 Gene

Protein tissue co-expression partners for ACTL9 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ACTL9 Gene:


SOURCE GeneReport for Unigene cluster for ACTL9 Gene:

genes like me logo Genes that share expression patterns with ACTL9: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ACTL9 Gene

Orthologs for ACTL9 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ACTL9 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ACTL9 34 35
  • 99.52 (n)
(Canis familiaris)
Mammalia ACTL9 34 35
  • 83.81 (n)
(Bos Taurus)
Mammalia ACTL9 34 35
  • 83.41 (n)
(Mus musculus)
Mammalia Actl9 34 16 35
  • 76.09 (n)
(Rattus norvegicus)
Mammalia Actl9 34
  • 75.9 (n)
(Monodelphis domestica)
Mammalia ACTL9 35
  • 63 (a)
(Gallus gallus)
Aves ACTL9 34 35
  • 56.59 (n)
(Anolis carolinensis)
Reptilia ACTL9 35
  • 54 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARP2 35
  • 31 (a)
Species where no ortholog for ACTL9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ACTL9 Gene

Gene Tree for ACTL9 (if available)
Gene Tree for ACTL9 (if available)

Paralogs for ACTL9 Gene

(21) SIMAP similar genes for ACTL9 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ACTL9: view

Variants for ACTL9 Gene

Sequence variations from dbSNP and Humsavar for ACTL9 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_043001 A colorectal cancer sample
VAR_043004 A colorectal cancer sample
rs10410943 -- 8,698,550(+) CCACC(A/G)CGCCG reference, missense
rs10416127 -- 8,699,866(+) TATTA(A/G/T)AATAT upstream-variant-2KB
rs11086000 -- 8,699,049(+) TTTGT(C/T)GCATG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ACTL9 Gene

Variant ID Type Subtype PubMed ID
dgv3425n100 CNV gain 25217958
dgv3426n100 CNV gain 25217958
esv2762024 CNV gain 21179565
nsv1057425 CNV gain 25217958
nsv1060576 CNV loss 25217958
nsv469648 CNV gain+loss 16826518
nsv469747 CNV gain+loss 16826518
nsv471705 CNV gain+loss 15918152
nsv833735 CNV gain+loss 17160897

Variation tolerance for ACTL9 Gene

Residual Variation Intolerance Score: 82.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.35; 26.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ACTL9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACTL9 Gene

Disorders for ACTL9 Gene

Relevant External Links for ACTL9

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ACTL9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ACTL9 Gene

Publications for ACTL9 Gene

  1. Correlation of KIF3A and OVOL1, but not ACTL9, with atopic dermatitis in Chinese pediatric patients. (PMID: 26127003) Kang Z. … Xu F. (Gene 2015) 3 64
  2. Association of KIF3A, but not OVOL1 and ACTL9, with atopic eczema in Italian patients. (PMID: 23278845) Lepre T. … Giardina E. (Br. J. Dermatol. 2013) 3 64
  3. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PMID: 22814378) Van Damme P. … Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012) 4 64
  4. Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis. (PMID: 22197932) Paternoster L. … Weidinger S. (Nat. Genet. 2012) 3 64
  5. The consensus coding sequences of human breast and colorectal cancers. (PMID: 16959974) Sjoeblom T. … Velculescu V.E. (Science 2006) 4 64

Products for ACTL9 Gene

Sources for ACTL9 Gene

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