ACTL8 Gene
protein-coding GIFtS: 40
GCID: GC01P018081
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|
actin-like 8
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Aliases
for ACTL8 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Actin-Like 81 2 | | CT571 2 3 | | Cancer/Testis Antigen 572 3 | | Actin Like Protein2 | | Actin-Like Protein 82 |
Export aliases for ACTL8 gene to outside databasesPrevious GC identifers: GC01P017828 GC01P017954 GC01P016396 |
Summaries
for ACTL8 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for ACTL8 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004610.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ACTL8 gene promoter:
Max1 MyoD LCR-F1 HNF-1A HNF-1 Chx10 c-Myb TGIF c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for ACTL8
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ACTL8 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p36.2-p35 Ensembl cytogenetic band: 1p36.13 HGNC cytogenetic band: 1p36.2-p35ACTL8 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P018081: view genomic region
(about GC identifiers)
Start:
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18,081,808 bp from pter |
End:
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18,153,558 bp from pter |
Size:
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71,751 bases |
Orientation:
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plus strand |
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Proteins
for ACTL8 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ACTL8_HUMAN, Q9H568 (See
protein sequence)Recommended Name: Actin-like protein 8 Size: 366 amino acids; 41360 Da
Subcellular location: Cytoplasm, cytoskeleton (By similarity)
Sequence caution: Sequence=AAA62476.1; Type=Frameshift; Positions=30, 49, 110, 127, 141, 344, 347, 354;
Secondary accessions: Q13104 Q96M75Explore the universe of human proteins at neXtProt for ACTL8: NX_Q9H568
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H568
ACTL8 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_110439.2
ENSEMBL proteins: ENSP00000364555
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
ACTL8 for ontologies About GeneDecksing
ACTL8 Antibody Products:
Assay Products for ACTL8: |
Protein
Domains /
Families
for ACTL8 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ACTL8 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9H568ProtoNet protein and cluster: Q9H568 1 Blocks protein family: IPB004000 Actin/actin-like
UniProtKB/Swiss-Prot: ACTL8_HUMAN, Q9H568Similarity: Belongs to the actin family |
Function
for ACTL8 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ACTL8
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ACTL8
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ACTL8 (NM_030812) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ACTL8 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACTL8 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACTL8 |
|
Pathways & Interactions
for ACTL8 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ACTL8
|
Drugs & Compounds
for ACTL8 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ACTL8
Search CenterWatch for drugs/clinical trials and news about ACTL8
|
Transcripts
for ACTL8 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ACTL8 gene: NM_030812.2 Unigene Cluster for ACTL8: Actin-like 8 Hs.2149 [show with all ESTs]Unigene Representative Sequence: NM_0308121 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000375406(uc001bat.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ACTL8
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ACTL8
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ACTL8 (NM_030812) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ACTL8 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACTL8 |
Additional cDNA sequence: AK057339.1 BC028909.1 U20582.1 1 DOTS entry: DT.408512 23 AceView cDNA sequences: CR611452 BF594459 BX104041 U20582 BX349148 BX341641 AA603752 BI254631 BI826094 BG819841 AA451808 BC028909 BX384367 AK057339 NM_030812 BP432535 BE672306 T25883 BM017730 AW291221 BM913957 T25884 AW800968
GeneLoc Exon Structure
|
Expression
for ACTL8 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ACTL8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCTGAGAGCC
About this image
See ACTL8 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ACTL8
SOURCE GeneReport for Unigene cluster: Hs.2149
UniProtKB/Swiss-Prot: ACTL8_HUMAN, Q9H568Tissue specificity: Strongly expressed in testis and pancreas. Weak expression in placenta
SABiosciences Custom PCR Arrays for ACTL8
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ACTL8
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ACTL8 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ACTL8 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ACTL8 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACTL8 |
Orthologs
for ACTL8 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for ACTL8 gene from 2/14 species (see all 14) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
ATARP76 |
actin-related protein 7 |
20(a) |
possible ortholog |
3(22474074-22476445) |
rice
(Oryza sativa) |
Liliopsida |
-- |
actin, putative, expressed |
18(a) |
possible ortholog |
3(32437237-32441779) |
ENSEMBL Gene Tree for ACTL8 (if available)
TreeFam Gene Tree for ACTL8 (if available) |
Paralogs
for ACTL8 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ACTL8 gene
- ACTR22 ACTL102
18/22 SIMAP similar genes for ACTL8 using alignment to 1 protein entry: ACTL8_HUMAN(see all similar genes):ACTB PS1TP5BP1 ACTG1 ACTBL2 ACTC1 POTEI
POTEJ ACTR1A ACTG2 POTEE POTEF POTEKP
ACTA2 ACTL7A ACTR1B ACTR2 ACTA1 ACTRT1
ACTL8 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for ACTL8
PGOHUM00000239715
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Genomic Variants
for ACTL8 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ACTL8 (18081808 - 18153558 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ACTL8: -- | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for ACTL8 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for ACTL8 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ACTL8 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ACTL8) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (2011)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- A proteomic approach towards the Hsp90-dependent ubiquitinylated proteome. (PubMed id 17623298)1 Falsone S.F....Kungl A.J. (2007)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
- Identification of cancer/testis-antigen genes by massively parallel signature sequencing. (PubMed id 15905330)2 Chen Y.-T.... Simpson A.J.G. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
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External Searches for ACTL8 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing ACTL8 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ACTL8 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ACTL8 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ACTL8 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ACTL8 gene:
Search GeneIP for patents involving ACTL8
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ACTL8 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for ACTL8 | | OriGene shRNA RFP for ACTL8 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ACTL8 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ACTL8 | | | OriGene Protein Over-expression Lysate for ACTL8 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ACTL8 | | OriGene 3'-UTR Clone for ACTL8 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ACTL8 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ACTL8 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ACTL8 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ACTL8 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ACTL8 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ACTL8 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ACTL8 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ACTL8 |
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 |  |  |  | |
| | | | Search Tocris compounds for ACTL8 |
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 | | | ACTL8 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACTL8 |
|  |  |  | | | | ThermoFisher Antibody for ACTL8 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACTL8 |
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