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Aliases for ACTL8 Gene

Aliases for ACTL8 Gene

  • Actin-Like 8 2 3
  • Cancer/Testis Antigen 57 2 3 4
  • CT57 3 4
  • Actin-Like Protein 8 3
  • Actin Like Protein 3

External Ids for ACTL8 Gene

Previous GeneCards Identifiers for ACTL8 Gene

  • GC01P017954
  • GC01P018081
  • GC01P016396

Summaries for ACTL8 Gene

GeneCards Summary for ACTL8 Gene

ACTL8 (Actin-Like 8) is a Protein Coding gene. An important paralog of this gene is ACTL7B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACTL8 Gene

Genomics for ACTL8 Gene

Regulatory Elements for ACTL8 Gene

Genomic Location for ACTL8 Gene

17,755,313 bp from pter
17,827,063 bp from pter
71,751 bases
Plus strand

Genomic View for ACTL8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ACTL8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACTL8 Gene

Proteins for ACTL8 Gene

  • Protein details for ACTL8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Actin-like protein 8
    Protein Accession:
    Secondary Accessions:
    • Q13104
    • Q96M75

    Protein attributes for ACTL8 Gene

    366 amino acids
    Molecular mass:
    41360 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAA62476.1; Type=Frameshift; Positions=30, 49, 110, 127, 141, 344, 347, 354; Evidence={ECO:0000305};

neXtProt entry for ACTL8 Gene

Proteomics data for ACTL8 Gene at MOPED

Post-translational modifications for ACTL8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ACTL8 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for ACTL8 Gene

Domains for ACTL8 Gene

Protein Domains for ACTL8 Gene


Suggested Antigen Peptide Sequences for ACTL8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9H568
  • Belongs to the actin family.
genes like me logo Genes that share domains with ACTL8: view

No data available for Gene Families for ACTL8 Gene

Function for ACTL8 Gene

Gene Ontology (GO) - Molecular Function for ACTL8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with ACTL8: view

Animal Model Products

CRISPR Products

miRNA for ACTL8 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ACTL8

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ACTL8 Gene

Localization for ACTL8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACTL8 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

Jensen Localization Image for ACTL8 Gene COMPARTMENTS Subcellular localization image for ACTL8 gene
Compartment Confidence
cytosol 3
cytoskeleton 2
nucleus 2

Gene Ontology (GO) - Cellular Components for ACTL8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with ACTL8: view

Pathways for ACTL8 Gene

SuperPathways for ACTL8 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ACTL8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030855 epithelial cell differentiation IEP 21492153
genes like me logo Genes that share ontologies with ACTL8: view

No data available for Pathways by source for ACTL8 Gene

Transcripts for ACTL8 Gene

mRNA/cDNA for ACTL8 Gene

Unigene Clusters for ACTL8 Gene

Actin-like 8:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ACTL8

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ACTL8 Gene

No ASD Table

Relevant External Links for ACTL8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ACTL8 Gene

mRNA expression in normal human tissues for ACTL8 Gene

mRNA differential expression in normal tissues according to GTEx for ACTL8 Gene

This gene is overexpressed in Testis (46.8).

Protein differential expression in normal tissues for ACTL8 Gene

This gene is overexpressed in Testis (51.4) and Ovary (12.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ACTL8 Gene

SOURCE GeneReport for Unigene cluster for ACTL8 Gene Hs.2149

mRNA Expression by UniProt/SwissProt for ACTL8 Gene

Tissue specificity: Strongly expressed in testis and pancreas. Weak expression in placenta.
genes like me logo Genes that share expressions with ACTL8: view

Expression partners for ACTL8 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for ACTL8 Gene

Orthologs for ACTL8 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ACTL8 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ACTL8 35
  • 78.26 (n)
  • 72.33 (a)
ACTL8 36
  • 72 (a)
(Canis familiaris)
Mammalia ACTL8 35
  • 82.28 (n)
  • 78.63 (a)
ACTL8 36
  • 78 (a)
(Pan troglodytes)
Mammalia ACTL8 35
  • 99.54 (n)
  • 99.73 (a)
ACTL8 36
  • 100 (a)
(Mus musculus)
Mammalia Gm16385 16
Actl11 36
  • 8 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 29 (a)
-- 36
  • 27 (a)
(Danio rerio)
Actinopterygii actr2a 36
  • 27 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARP2 36
  • 26 (a)
Species with no ortholog for ACTL8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ACTL8 Gene

Gene Tree for ACTL8 (if available)
Gene Tree for ACTL8 (if available)

Paralogs for ACTL8 Gene

Paralogs for ACTL8 Gene

Selected SIMAP similar genes for ACTL8 Gene using alignment to 1 proteins: Pseudogenes for ACTL8 Gene

genes like me logo Genes that share paralogs with ACTL8: view

Variants for ACTL8 Gene

Sequence variations from dbSNP and Humsavar for ACTL8 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs174285 -- 17,800,551(+) gttgc(A/G/T)cagtg intron-variant
rs260517 -- 17,803,663(+) gagga(C/T)ggact intron-variant
rs260518 -- 17,799,133(+) TCTCT(A/G)GGGGG intron-variant
rs260519 -- 17,784,206(+) TTAAC(A/G)TGGTG intron-variant
rs260520 -- 17,781,131(+) ctggc(A/G)tgtgg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ACTL8 Gene

Variant ID Type Subtype PubMed ID
nsv508248 CNV Loss 20534489
esv2669735 CNV Deletion 23128226

Relevant External Links for ACTL8 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACTL8 Gene

Disorders for ACTL8 Gene

Relevant External Links for ACTL8

Genetic Association Database (GAD)

No disorders were found for ACTL8 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for ACTL8 Gene

Publications for ACTL8 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. A proteomic approach towards the Hsp90-dependent ubiquitinylated proteome. (PMID: 17623298) Falsone S.F. … Kungl A.J. (Proteomics 2007) 3
  3. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3
  4. Analysis of proteomic changes induced upon cellular differentiation of the human intestinal cell line Caco-2. (PMID: 21492153) Buhrke T. … Lampen A. (Dev. Growth Differ. 2011) 3
  5. Global identification of modular cullin-RING ligase substrates. (PMID: 21963094) Emanuele M.J. … Elledge S.J. (Cell 2011) 3

Products for ACTL8 Gene

Sources for ACTL8 Gene

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