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Aliases for ACTL8 Gene

Aliases for ACTL8 Gene

  • Actin Like 8 2 3 5
  • Cancer/Testis Antigen 57 2 3 4
  • CT57 3 4
  • Actin-Like Protein 8 3
  • Actin Like Protein 3

External Ids for ACTL8 Gene

Previous GeneCards Identifiers for ACTL8 Gene

  • GC01P017828
  • GC01P017954
  • GC01P018081
  • GC01P016396

Summaries for ACTL8 Gene

GeneCards Summary for ACTL8 Gene

ACTL8 (Actin Like 8) is a Protein Coding gene. An important paralog of this gene is ACTR1A.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACTL8 Gene

Genomics for ACTL8 Gene

Regulatory Elements for ACTL8 Gene

Enhancers for ACTL8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G017716 0.7 FANTOM5 dbSUPER 0.7 +4.5 4511 0.2 ZNF366 ZNF341 RCC2 ACTL8 ENSG00000236648
GH01G017629 1.6 FANTOM5 Ensembl ENCODE dbSUPER 0.2 -81.6 -81595 2.2 CTCF PKNOX1 ZNF473 RAD21 ZNF121 SCRT2 ZNF600 PRDM10 ZNF263 BHLHE40 ARHGEF10L PADI4 GC01P017551 ACTL8
GH01G017665 0.8 dbSUPER 0.3 -44.7 -44684 3.5 BCOR NFIB ZMYM3 KLF17 MAX RAD21 YY1 GATA3 ADNP ZNF416 ACTL8 GC01P017551
GH01G017669 0.7 dbSUPER 0.3 -40.9 -40935 3.1 BCOR CTCF ZNF223 ZMYM3 RAD21 ZFHX2 POLR2A SCRT2 ADNP SMC3 ACTL8 GC01P017551
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ACTL8 on UCSC Golden Path with GeneCards custom track

Genomic Location for ACTL8 Gene

17,712,000 bp from pter
17,827,063 bp from pter
115,064 bases
Plus strand

Genomic View for ACTL8 Gene

Genes around ACTL8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACTL8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACTL8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACTL8 Gene

Proteins for ACTL8 Gene

  • Protein details for ACTL8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Actin-like protein 8
    Protein Accession:
    Secondary Accessions:
    • Q13104
    • Q96M75

    Protein attributes for ACTL8 Gene

    366 amino acids
    Molecular mass:
    41360 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAA62476.1; Type=Frameshift; Positions=30, 49, 110, 127, 141, 344, 347, 354; Evidence={ECO:0000305};

neXtProt entry for ACTL8 Gene

Post-translational modifications for ACTL8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ACTL8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ACTL8 Gene

Domains & Families for ACTL8 Gene

Gene Families for ACTL8 Gene

Protein Domains for ACTL8 Gene


Suggested Antigen Peptide Sequences for ACTL8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the actin family.
  • Belongs to the actin family.
genes like me logo Genes that share domains with ACTL8: view

Function for ACTL8 Gene

Gene Ontology (GO) - Molecular Function for ACTL8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with ACTL8: view
genes like me logo Genes that share phenotypes with ACTL8: view

Animal Model Products

CRISPR Products

miRNA for ACTL8 Gene

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ACTL8 Gene

Localization for ACTL8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACTL8 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ACTL8 gene
Compartment Confidence
cytosol 4
cytoskeleton 3
nucleus 2

Gene Ontology (GO) - Cellular Components for ACTL8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with ACTL8: view

Pathways & Interactions for ACTL8 Gene

SuperPathways for ACTL8 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ACTL8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030855 epithelial cell differentiation IEP 21492153
genes like me logo Genes that share ontologies with ACTL8: view

No data available for Pathways by source and SIGNOR curated interactions for ACTL8 Gene

Drugs & Compounds for ACTL8 Gene

No Compound Related Data Available

Transcripts for ACTL8 Gene

mRNA/cDNA for ACTL8 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(23) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ACTL8 Gene

Actin-like 8:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ACTL8 Gene

No ASD Table

Relevant External Links for ACTL8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ACTL8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ACTL8 Gene

mRNA differential expression in normal tissues according to GTEx for ACTL8 Gene

This gene is overexpressed in Testis (x46.8).

Protein differential expression in normal tissues from HIPED for ACTL8 Gene

This gene is overexpressed in Testis (51.4) and Ovary (12.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ACTL8 Gene

Protein tissue co-expression partners for ACTL8 Gene

NURSA nuclear receptor signaling pathways regulating expression of ACTL8 Gene:


SOURCE GeneReport for Unigene cluster for ACTL8 Gene:


mRNA Expression by UniProt/SwissProt for ACTL8 Gene:

Tissue specificity: Strongly expressed in testis and pancreas. Weak expression in placenta.

Evidence on tissue expression from TISSUES for ACTL8 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ACTL8: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for ACTL8 Gene

Orthologs for ACTL8 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ACTL8 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ACTL8 35 34
  • 99.54 (n)
(Canis familiaris)
Mammalia ACTL8 34 35
  • 82.28 (n)
(Bos Taurus)
Mammalia ACTL8 35 34
  • 78.26 (n)
(Monodelphis domestica)
Mammalia -- 35
  • 29 (a)
-- 35
  • 27 (a)
(Mus musculus)
Mammalia Actl11 35
  • 8 (a)
(Danio rerio)
Actinopterygii actr2a 35
  • 27 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARP2 35
  • 26 (a)
Species where no ortholog for ACTL8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ACTL8 Gene

Gene Tree for ACTL8 (if available)
Gene Tree for ACTL8 (if available)

Paralogs for ACTL8 Gene

Paralogs for ACTL8 Gene

(23) SIMAP similar genes for ACTL8 Gene using alignment to 1 proteins: Pseudogenes for ACTL8 Gene

genes like me logo Genes that share paralogs with ACTL8: view

Variants for ACTL8 Gene

Sequence variations from dbSNP and Humsavar for ACTL8 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000000510 -- 17,754,892(+) AAAAC(C/T)TGATG upstream-variant-2KB
rs1000013390 -- 17,820,438(+) TTGGC(A/G)GTTAG intron-variant
rs1000046339 -- 17,781,674(+) CTGGG(G/T)TAGAC intron-variant
rs1000069946 -- 17,796,640(+) GGAAT(A/G)CTGGG intron-variant
rs1000207830 -- 17,824,857(+) TGAAA(A/C)AGAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ACTL8 Gene

Variant ID Type Subtype PubMed ID
esv2669735 CNV deletion 23128226
esv3585376 CNV loss 21293372
nsv1160182 CNV duplication 26073780
nsv508248 CNV deletion 20534489

Variation tolerance for ACTL8 Gene

Residual Variation Intolerance Score: 81.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.59; 44.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ACTL8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACTL8 Gene

Disorders for ACTL8 Gene

Relevant External Links for ACTL8

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ACTL8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ACTL8 Gene

Publications for ACTL8 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  4. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3 64
  5. Analysis of proteomic changes induced upon cellular differentiation of the human intestinal cell line Caco-2. (PMID: 21492153) Buhrke T. … Lampen A. (Dev. Growth Differ. 2011) 3 64

Products for ACTL8 Gene

Sources for ACTL8 Gene

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