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Aliases for ACTL7A Gene

Aliases for ACTL7A Gene

  • Actin-Like 7A 2 3
  • Actin-Like-7-Alpha 3 4
  • Actin-Like Protein 7A 3
  • Actin-Like 7-Alpha 3

External Ids for ACTL7A Gene

Previous GeneCards Identifiers for ACTL7A Gene

  • GC09P102422
  • GC09P103356
  • GC09P105082
  • GC09P107004
  • GC09P108704
  • GC09P110664
  • GC09P111624
  • GC09P081224

Summaries for ACTL7A Gene

Entrez Gene Summary for ACTL7A Gene

  • The protein encoded by this gene is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene (ACTL7A), and related gene, ACTL7B, are intronless, and are located approximately 4 kb apart in a head-to-head orientation within the familial dysautonomia candidate region on 9q31. Based on mutational analysis of the ACTL7A gene in patients with this disorder, it was concluded that it is unlikely to be involved in the pathogenesis of dysautonomia. The ACTL7A gene is expressed in a wide variety of adult tissues, however, its exact function is not known. [provided by RefSeq, Jul 2008]

GeneCards Summary for ACTL7A Gene

ACTL7A (Actin-Like 7A) is a Protein Coding gene. Diseases associated with ACTL7A include hypertensive nephropathy. GO annotations related to this gene include structural constituent of cytoskeleton. An important paralog of this gene is ACTL7B.

Gene Wiki entry for ACTL7A Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACTL7A Gene

Genomics for ACTL7A Gene

Regulatory Elements for ACTL7A Gene

Genomic Location for ACTL7A Gene

108,862,228 bp from pter
108,863,759 bp from pter
1,532 bases
Plus strand

Genomic View for ACTL7A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ACTL7A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACTL7A Gene

Proteins for ACTL7A Gene

  • Protein details for ACTL7A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Actin-like protein 7A
    Protein Accession:
    Secondary Accessions:
    • B2RC83
    • Q5JSV0

    Protein attributes for ACTL7A Gene

    435 amino acids
    Molecular mass:
    48644 Da
    Quaternary structure:
    • Interacts (via N-terminus) with TES (via LIM domain 2). Heterodimer with TES; the heterodimer interacts with ENAH to form a heterotrimer.

    Three dimensional structures from OCA and Proteopedia for ACTL7A Gene

neXtProt entry for ACTL7A Gene

Proteomics data for ACTL7A Gene at MOPED

Post-translational modifications for ACTL7A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ACTL7A Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for ACTL7A Gene

Domains for ACTL7A Gene

Protein Domains for ACTL7A Gene


Suggested Antigen Peptide Sequences for ACTL7A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the actin family.
  • Belongs to the actin family.
genes like me logo Genes that share domains with ACTL7A: view

No data available for Gene Families for ACTL7A Gene

Function for ACTL7A Gene

Molecular function for ACTL7A Gene

GENATLAS Biochemistry:
actin-like 7A,isolated from the HSAN3 region,widely expressed,mouse Arp7a ortholog,ARP (actin related proteins) superfamily

Gene Ontology (GO) - Molecular Function for ACTL7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005200 structural constituent of cytoskeleton TAS 10373328
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with ACTL7A: view

Animal Model Products

miRNA for ACTL7A Gene

miRTarBase miRNAs that target ACTL7A

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ACTL7A

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ACTL7A Gene

Localization for ACTL7A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACTL7A Gene

Cytoplasm, cytoskeleton. Golgi apparatus. Cytoplasm. Nucleus. Note=Detected at the Golgi apparatus during acrosome biogenesis. Detected at the subacrosomal layer in round spermatids. Detected in sperm head and tail (By similarity). {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for ACTL7A Gene COMPARTMENTS Subcellular localization image for ACTL7A gene
Compartment Confidence
cytoskeleton 4
cytosol 3
nucleus 3
golgi apparatus 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ACTL7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001673 male germ cell nucleus IEA --
GO:0005634 nucleus IDA 21630459
GO:0005737 cytoplasm ISS --
GO:0005794 colocalizes_with Golgi apparatus ISS --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with ACTL7A: view

Pathways for ACTL7A Gene

SuperPathways for ACTL7A Gene

No Data Available

Gene Ontology (GO) - Biological Process for ACTL7A Gene


No data available for Pathways by source for ACTL7A Gene

Transcripts for ACTL7A Gene

mRNA/cDNA for ACTL7A Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(33) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ACTL7A Gene

Actin-like 7A:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ACTL7A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ACTL7A Gene

No ASD Table

Relevant External Links for ACTL7A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ACTL7A Gene

mRNA expression in normal human tissues for ACTL7A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ACTL7A Gene

This gene is overexpressed in Testis (52.5).

Protein differential expression in normal tissues for ACTL7A Gene

This gene is overexpressed in Testis (53.0) and Ovary (16.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ACTL7A Gene

SOURCE GeneReport for Unigene cluster for ACTL7A Gene Hs.123530

mRNA Expression by UniProt/SwissProt for ACTL7A Gene

Tissue specificity: Strongly expressed in testis. Also expressed in other tissues.
genes like me logo Genes that share expressions with ACTL7A: view

Expression partners for ACTL7A Gene

* - Elite partner

Primer Products

In Situ Assay Products

Orthologs for ACTL7A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ACTL7A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ACTL7A 35
  • 86.53 (n)
  • 87.3 (a)
  • 86 (a)
(Canis familiaris)
Mammalia ACTL7A 35
  • 87.28 (n)
  • 87.59 (a)
  • 87 (a)
(Mus musculus)
Mammalia Actl7a 35
  • 83.98 (n)
  • 85.98 (a)
Actl7a 16
Actl7a 36
  • 85 (a)
(Pan troglodytes)
Mammalia ACTL7A 35
  • 99.08 (n)
  • 99.08 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Actl7a 35
  • 84.67 (n)
  • 86.44 (a)
(Monodelphis domestica)
Mammalia ACTL7A 36
  • 72 (a)
(Anolis carolinensis)
Reptilia ACTL7A 36
  • 67 (a)
(Danio rerio)
Actinopterygii zgc:101810 36
  • 32 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARP2 36
  • 30 (a)
Species with no ortholog for ACTL7A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ACTL7A Gene

Gene Tree for ACTL7A (if available)
Gene Tree for ACTL7A (if available)

Paralogs for ACTL7A Gene

Paralogs for ACTL7A Gene

(23) SIMAP similar genes for ACTL7A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ACTL7A: view

Variants for ACTL7A Gene

Sequence variations from dbSNP and Humsavar for ACTL7A Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs1054744 -- 108,863,636(+) ACAGC(A/G)ACGAG utr-variant-3-prime
rs3739692 -- 108,862,850(+) AGCCC(A/T)CACAC reference, synonymous-codon
rs3739693 -- 108,862,979(+) GAGGT(A/G)GGCCA synonymous-codon, reference
rs4978369 -- 108,860,660(+) AAAGT(C/G)AAACA upstream-variant-2KB
rs4978370 -- 108,863,633(+) TGAAC(A/G)GCGAC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ACTL7A Gene

Variant ID Type Subtype PubMed ID
nsv6659 CNV Insertion 18451855

Relevant External Links for ACTL7A Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACTL7A Gene

Disorders for ACTL7A Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for ACTL7A Gene in MalaCards »

(1) Disease for ACTL7A Gene

(1) University of Copenhagen DISEASES for ACTL7A Gene

Relevant External Links for ACTL7A

Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with ACTL7A: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for ACTL7A Gene

Publications for ACTL7A Gene

  1. Cloning, mapping, and expression of two novel actin genes, actin- like-7A (ACTL7A) and actin-like-7B (ACTL7B), from the familial dysautonomia candidate region on 9q31. (PMID: 10373328) Chadwick B.P. … Slaugenhaupt S.A. (Genomics 1999) 2 3 4 23
  2. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Molecular recognition of the Tes LIM2-3 domains by the actin-related protein Arp7A. (PMID: 21278383) Boeda B. … Way M. (J. Biol. Chem. 2011) 3 4
  5. Proteomic characterization of the human sperm nucleus. (PMID: 21630459) de Mateo S. … Oliva R. (Proteomics 2011) 3

Products for ACTL7A Gene

Sources for ACTL7A Gene

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