ACTL6A Gene
protein-coding GIFtS: 59
GCID: GC03P179280
|
|
actin-like 6A
| |
Aliases
for ACTL6A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Actin-Like 6A1 2 | | Baf53a1 | | BAF53A1 2 3 5 | | ACTL62 | | INO80K1 2 3 | | ARPN-BETA2 | | BAF532 3 5 | | Actin-Like Protein 6A2 | | Arp41 2 | | Actin-Related Protein 42 | | Actin-Related Protein Baf53a2 3 | | ArpNbeta3 | | 53 KDa BRG1-Associated Factor A2 3 | | BAF Complex 53 KDa Subunit2 | | BRG1-Associated Factor 53A2 3 | | HArpN Beta2 | | INO80 Complex Subunit K2 3 | | ArpNbeta3 | | Actl61 | | |
Export aliases for ACTL6A gene to outside databasesPrevious GC identifers: GC03P180763 GC03P176684 |
Summaries
for ACTL6A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ACTL6A:
This gene encodes a family member of actin-related proteins (ARPs), which share significant amino acid sequenceidentity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a commonfeature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation,nuclear migration and chromatin remodeling. This gene encodes a 53 kDa subunit protein of the BAF (BRG1/brm-associatedfactor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; thelatter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediatedtranscriptional repression. Together with beta-actin, it is required for maximal ATPase activity of BRG1, and for theassociation of the BAF complex with chromatin/matrix. Three transcript variants that encode two different proteinisoforms have been described. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: ACL6A_HUMAN, O96019Function: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration ofDNA-nucleosome topology). Required for maximal ATPase activity of SMARCA4/BRG1/BAF190A and for association of theSMARCA4/BRG1/BAF190A containing remodeling complex BAF with chromatin/nuclear matrix. Belongs to the neuralprogenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neuralprogenitors. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodelingmechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition fromproliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of thenpBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes whichcontain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B orDPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for theself-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays arole regulating the activity of genes essential for dendrite growth (By similarity). Component of the NuA4 histoneacetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally byacetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions andpromote interaction of the modified histones with other proteins which positively regulate transcription. This complexmay be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediatedgrowth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4may also play a direct role in DNA repair when recruited to sites of DNA damage. Also involved in vitamin D-coupledtranscription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited byvitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene.Putative core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNAreplication and probably DNA repair
Gene Wiki entry for ACTL6A
|
Genomic Views
for ACTL6A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_005612.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ACTL6A gene promoter:
AhR HFH-3 CUTL1 Arnt FOXI1 POU2F1 POU2F1a NF-Y CBF(2)
Other transcription factors
Search SABiosciences Chromatin IP Primers for ACTL6A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ACTL6A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q26.33 Ensembl cytogenetic band: 3q26.33 HGNC cytogenetic band: 3q26.33ACTL6A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P179280: view genomic region
(about GC identifiers)
Start:
|
179,280,668 bp from pter |
End:
|
179,306,196 bp from pter |
Size:
|
25,529 bases |
Orientation:
|
plus strand |
|
Proteins
for ACTL6A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ACL6A_HUMAN, O96019 (See
protein sequence)Recommended Name: Actin-like protein 6A Size: 429 amino acids; 47461 Da
Subunit: Component of numerous complexes with chromatin remodeling and histone acetyltransferase activity. Component ofthe NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400,TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15,MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. The NuA4 complex interacts with MYC and the adenovirus E1Aprotein. Component of a NuA4-related complex which contains EP400, TRRAP/PAF400, SRCAP, BRD8/SMAP, EPC1, DMAP1/DNMAP1,RUVBL1/TIP49, RUVBL2, actin, ACTL6A/BAF53A, VPS72 and YEATS4/GAS41. Component of the BAF complex, which includes atleast actin (ACTB), ARID1A, ARID1B/BAF250, SMARCA2, SMARCA4/BRG1/BAF190A, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57,SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more of SMARCD1/BAF60A, SMARCD2/BAF60B, orSMARCD3/BAF60C. In muscle cells, the BAF complex also contains DPF3. Component of the BAF53 complex, at least composedof ACTL6A/BAF53A, RUVBL1/TIP49, SMARCA2/BRM/BAF190B, and TRRAP/PAF400, and which may also include a HAT activityrelated to, but distinct from, that of KAT5. ACTL6A interacts with SMARCA4/BRG1/BAF190A. Component of the chromatinremodeling INO80 complex; specifically part of a complex module associated with the DBINO domain of INO80. Componentof the WINAC complex, at least composed of SMARCA2, SMARCA4, SMARCB1, SMARCC1, SMARCC2, SMARCD1, SMARCE1, ACTL6A,BAZ1B/WSTF, ARID1A, SUPT16H, CHAF1A and TOP2B. Component of neural progenitors-specific chromatin remodeling complex(npBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C,SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, PHF10/BAF45A,ACTL6A/BAF53A and actin. Interacts with PHF10/BAF45A (By similarity)
Subcellular location: Nucleus
Secondary accessions: B3KMN1 D3DNR9 Q8TAE5 Q9BVS8 Q9H0W6Alternative splicing: 2 isoforms: O96019-1 O96019-2 Explore the universe of human proteins at neXtProt for ACTL6A: NX_O96019
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O96019
ACTL6A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_004292.1 NP_817126.1 NP_829888.1
ENSEMBL proteins: ENSP00000397552 ENSP00000394014 ENSP00000420153 ENSP00000420694 ENSP00000376430
Human Recombinant Protein Products:
Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table
ACTL6A for ontologies About GeneDecksing
ACTL6A Antibody Products:
Assay Products for ACTL6A: |
Protein
Domains /
Families
for ACTL6A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ACTL6A for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O96019ProtoNet protein and cluster: O96019 1 Blocks protein family: IPB004000 Actin/actin-like
UniProtKB/Swiss-Prot: ACL6A_HUMAN, O96019Similarity: Belongs to the actin family |
Function
for ACTL6A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ACL6A_HUMAN, O96019Function: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration ofDNA-nucleosome topology). Required for maximal ATPase activity of SMARCA4/BRG1/BAF190A and for association of theSMARCA4/BRG1/BAF190A containing remodeling complex BAF with chromatin/nuclear matrix. Belongs to the neuralprogenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neuralprogenitors. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodelingmechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition fromproliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of thenpBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes whichcontain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B orDPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for theself-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays arole regulating the activity of genes essential for dendrite growth (By similarity). Component of the NuA4 histoneacetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally byacetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions andpromote interaction of the modified histones with other proteins which positively regulate transcription. This complexmay be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediatedgrowth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4may also play a direct role in DNA repair when recruited to sites of DNA damage. Also involved in vitamin D-coupledtranscription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited byvitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene.Putative core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNAreplication and probably DNA repair
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ACTL6A (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ACTL6A (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): ACTL6A (NM_004301) | |  | Sino Biological Human cDNA Clone for ACTL6A | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ACTL6A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACTL6A |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACTL6A |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
ACTL6A for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for ACTL6A:
Animal Models:
Mouse knock-out Actl6atm1.2Grc for ACTL6A
3 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Actl6a):
ACTL6A for phenotypes About GeneDecksing
|
Pathways & Interactions
for ACTL6A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Development_Ligand-dependent activation of the ESR1/AP-1 pathway | | | 2 | TNF-alpha/NF-kB Signaling Pathway | | | 3 | Validated targets of C-MYC transcriptional activation | | | 4 | C-MYC pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 EMD Millipore Pathways for ACTL6A
2  GeneGo (Thomson Reuters) Pathways for ACTL6A
3  BioSystems Pathways for ACTL6A
ACTL6A for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ACTL6A
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/828 Interacting proteins for ACTL6A (O960191, 2, 3 ENSP000003975524) via UniProtKB, MINT, STRING, and/or I2D (see all 828)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| DMAP1 | Q9NPF52, 3, ENSP000003126974 | MINT-7945693 MINT-7947479 I2D:
score=5 STRING: ENSP00000312697 | | RUVBL2 | Q9Y2302, 3, ENSP000002214134 | MINT-7945693 MINT-7947479 I2D:
score=3 STRING: ENSP00000221413 | | SMARCB1 | Q128242, 3, ENSP000002631214 | MINT-7945693 MINT-7947479 I2D:
score=3 STRING: ENSP00000263121 | | RELB | Q012012, 3, ENSP000002214524 | MINT-49026 MINT-48012 I2D:
score=2 STRING: ENSP00000221452 | | SMARCD1 | Q96GM52, 3, ENSP000003784144 | MINT-7945693 MINT-7947479 I2D:
score=2 STRING: ENSP00000378414 |
About this table
Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11): About this table
ACTL6A for ontologies About GeneDecksing
|
Drugs & Compounds
for ACTL6A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ACTL6A
Search CenterWatch for drugs/clinical trials and news about ACTL6A / ACL6A
|
Transcripts
for ACTL6A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ACTL6A gene (3 alternative transcripts): NM_004301.3 NM_177989.2 NM_178042.2 Unigene Cluster for ACTL6A: Actin-like 6A Hs.435326 [show with all ESTs]Unigene Representative Sequence: NM_17804215 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000429709(uc003fjw.3) ENST00000450518(uc003fjx.3) ENST00000463661
ENST00000491202 ENST00000468767 ENST00000494843 ENST00000490364 ENST00000487978
ENST00000486471 ENST00000467383 ENST00000467615 ENST00000479056 ENST00000484312
ENST00000461125 ENST00000392662(uc003fjy.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ACTL6A (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ACTL6A (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): ACTL6A (NM_004301) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ACTL6A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACTL6A |
Additional cDNA sequence: AB015907.1 AB060168.1 AB061315.1 AF041474.1 AK021756.1 AK098691.1 AK223212.1 AL136608.1 BC000949.2 BC001391.2 BC035463.1 BC036371.1 CR533529.1 24 DOTS entries: DT.100644276 DT.97854874 DT.97854877 DT.100677949 DT.99974241 DT.75153580 DT.100677955 DT.100677947 DT.120844898 DT.91771219 DT.91948208 DT.91735736 DT.99977438 DT.120844893 DT.75195352 DT.100030183 DT.100677952 DT.120844830 DT.120844841 DT.91900106 DT.92018212 DT.97787640 DT.100677962 DT.99952388 24/391 AceView cDNA sequences (see all 391): AK098691 BX415072 CR594699 BC000949 AA580994 AI565164 BI258818 BG255182 AA262696 BX415379 AI368400 BP374300 AW401379 BX379778 BQ694874 BE465991 AA631545 BQ433703 BM461556 BU630618 BX446079 CA450440 BQ435959 AU119086
GeneLoc Exon Structure
5/10 Alternative Splicing Database (ASD) splice patterns (SP) for ACTL6A (see all 10) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · |
|---|
|
| SP1: | | | | | - | | - | | | | | | - | | | | | | | | - | | - | | - | | - | | - | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | - | | | | | | | | - | | - | | - | | - | | - | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | - | | - | | | | | | - | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | - | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 15b |
|---|
|
| SP1: | | | |
| SP2: | | | |
| SP3: | | | |
| SP4: | | | |
| SP5: | | |
ECgene alternative splicing isoforms for ACTL6A
|
Expression
for ACTL6A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ACTL6A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GATTGGCGGC
About this image
See ACTL6A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ACTL6A
SOURCE GeneReport for Unigene cluster: Hs.435326
SABiosciences Custom PCR Arrays for ACTL6A
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ACTL6A
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ACTL6A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ACTL6A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ACTL6A | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACTL6A |
Orthologs
for ACTL6A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for ACTL6A gene from 8/30 species (see all 30) About this table
ENSEMBL Gene Tree for ACTL6A (if available)
TreeFam Gene Tree for ACTL6A (if available) |
Paralogs
for ACTL6A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ACTL6A gene
- ACTL6B2
18/21 SIMAP similar genes for ACTL6A using alignment to 4 protein entries: ACL6A_HUMAN (see all proteins)
(see all similar genes):BAF53A ACTL6B ACT ACTR1A ACTA1 ACTG1
ACTBL2 ACTC1 POTEKP PS1TP5BP1 ACTR1B POTEE
POTEF POTEI POTEJ ACTG2 ACTA2 ACTB
ACTL6A for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for ACTL6A
PGOHUM00000248163
|
Genomic Variants
for ACTL6A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ACTL6A (179280668 - 179306196 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ACTL6A
1 CNV: 1655 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ACTL6A |
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Disorders
/ Diseases
for ACTL6A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
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ACTL6A for disorders About GeneDecksing
OMIM gene information: 604958
OMIM disorders: --
10  diseases for ACTL6A: About MalaCardseaf fanconi's anemia williams syndrome anemia
cervical cancer cervicitis neuroblastoma malaria
leukemia neuronitis
Export disorders for ACTL6A gene to outside databases
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Publications
for ACTL6A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ACTL6A gene, integrated from 9 sources (see all 83):
(articles sorted by number of sources associating them with ACTL6A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Rapid and phosphoinositol-dependent binding of the SWI/SNF-like BAF complex to chromatin after T lymphocyte receptor signaling. (PubMed id 9845365)1, 2, 3, 9 Zhao K....Crabtree G.R. (1998)
- Two isoforms of a human actin-related protein show nuclear localization and mutually selective expression between brain and other tissues. (PubMed id 10380635)1, 2, 3 Harata M.... Mizuno S. (1999)
- Subunit organization of the human INO80 chromatin remodeling complex: An evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling. (PubMed id 21303910)1, 2 Chen L.... Conaway R.C. (2011)
- Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin-remodeling complex. (PubMed id 18922472)1, 2 Yao T....Conaway J.W. (2008)
- A YY1-INO80 complex regulates genomic stability through homologous recombination-based repair. (PubMed id 18026119)1, 2 Wu S.... Shi Y. (2007)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The highly conserved and multifunctional NuA4 HAT complex. (PubMed id 15196461)1, 2 Doyon Y. and Cote J. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans. (PubMed id 14966270)1, 2 Doyon Y.... Cote J. (2004)
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External Searches for ACTL6A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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|
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Genome Databases showing ACTL6A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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|
|
Other Databases showing ACTL6A gene
(According to HUGE)
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| -- |
Specialized Databases showing ACTL6A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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|
| Name | Description |
| PharmGKB entry for ACTL6A | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for ACTL6A gene:
Search GeneIP for patents involving ACTL6A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ACTL6A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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