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Aliases for ACTL6A Gene

Aliases for ACTL6A Gene

  • Actin-Like 6A 2 3
  • INO80 Complex Subunit K 2 3 4
  • BAF53A 3 4 6
  • BAF53 3 4 6
  • 53 KDa BRG1-Associated Factor A 3 4
  • Actin-Related Protein Baf53a 3 4
  • BAF Complex 53 KDa Subunit 2 3
  • BRG1-Associated Factor 53A 3 4
  • Actin-Related Protein 4 2 3
  • ArpNbeta 3 4
  • INO80K 3 4
  • BRG1-Associated Factor 2
  • Actin-Like Protein 6A 3
  • HArpN Beta 3
  • ARPN-BETA 3
  • ACTL6 3
  • Arp4 3

External Ids for ACTL6A Gene

Summaries for ACTL6A Gene

Entrez Gene Summary for ACTL6A Gene

  • This gene encodes a family member of actin-related proteins (ARPs), which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a 53 kDa subunit protein of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. Together with beta-actin, it is required for maximal ATPase activity of BRG1, and for the association of the BAF complex with chromatin/matrix. Three transcript variants that encode two different protein isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for ACTL6A Gene

ACTL6A (Actin-Like 6A) is a Protein Coding gene. Among its related pathways are Transcription Ligand-dependent activation of the ESR1/SP pathway and Prostate Cancer. GO annotations related to this gene include chromatin binding and transcription coactivator activity. An important paralog of this gene is ACTL6B.

UniProtKB/Swiss-Prot for ACTL6A Gene

  • Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for maximal ATPase activity of SMARCA4/BRG1/BAF190A and for association of the SMARCA4/BRG1/BAF190A containing remodeling complex BAF with chromatin/nuclear matrix. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Putative core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.

Gene Wiki entry for ACTL6A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACTL6A Gene

Genomics for ACTL6A Gene

Genomic Location for ACTL6A Gene

Start:
179,562,880 bp from pter
End:
179,588,408 bp from pter
Size:
25,529 bases
Orientation:
Plus strand

Genomic View for ACTL6A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ACTL6A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACTL6A Gene

Regulatory Elements for ACTL6A Gene

Proteins for ACTL6A Gene

  • Protein details for ACTL6A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O96019-ACL6A_HUMAN
    Recommended name:
    Actin-like protein 6A
    Protein Accession:
    O96019
    Secondary Accessions:
    • B3KMN1
    • D3DNR9
    • Q8TAE5
    • Q9BVS8
    • Q9H0W6

    Protein attributes for ACTL6A Gene

    Size:
    429 amino acids
    Molecular mass:
    47461 Da
    Quaternary structure:
    • Component of numerous complexes with chromatin remodeling and histone acetyltransferase activity. Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. The NuA4 complex interacts with MYC and the adenovirus E1A protein. Component of a NuA4-related complex which contains EP400, TRRAP/PAF400, SRCAP, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, actin, ACTL6A/BAF53A, VPS72 and YEATS4/GAS41. Component of the BAF complex, which includes at least actin (ACTB), ARID1A, ARID1B/BAF250, SMARCA2, SMARCA4/BRG1/BAF190A, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57, SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more of SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C. In muscle cells, the BAF complex also contains DPF3. Component of the BAF53 complex, at least composed of ACTL6A/BAF53A, RUVBL1/TIP49, SMARCA2/BRM/BAF190B, and TRRAP/PAF400, and which may also include a HAT activity related to, but distinct from, that of KAT5. ACTL6A interacts with SMARCA4/BRG1/BAF190A. Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the DBINO domain of INO80. Component of neural progenitors-specific chromatin remodeling complex (npBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, PHF10/BAF45A, ACTL6A/BAF53A and actin. Interacts with PHF10/BAF45A (By similarity).

    Alternative splice isoforms for ACTL6A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ACTL6A Gene

Proteomics data for ACTL6A Gene at MOPED

Post-translational modifications for ACTL6A Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys62, Lys89, Lys112, Lys226, Lys379, and Lys421

Other Protein References for ACTL6A Gene

No data available for DME Specific Peptides for ACTL6A Gene

Domains for ACTL6A Gene

Gene Families for ACTL6A Gene

HGNC:
  • INO80 :INO80 complex subunits

Protein Domains for ACTL6A Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

ACL6A_HUMAN
Family:
  • Belongs to the actin family.:
    • O96019
genes like me logo Genes that share domains with ACTL6A: view

Function for ACTL6A Gene

Molecular function for ACTL6A Gene

UniProtKB/Swiss-Prot Function: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for maximal ATPase activity of SMARCA4/BRG1/BAF190A and for association of the SMARCA4/BRG1/BAF190A containing remodeling complex BAF with chromatin/nuclear matrix. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Putative core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.

Gene Ontology (GO) - Molecular Function for ACTL6A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 contributes_to RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 16217013
GO:0000980 contributes_to RNA polymerase II distal enhancer sequence-specific DNA binding IDA 16217013
GO:0003682 chromatin binding TAS 9845365
GO:0003713 transcription coactivator activity NAS 8804307
GO:0005515 protein binding IPI 18026119
genes like me logo Genes that share ontologies with ACTL6A: view
genes like me logo Genes that share phenotypes with ACTL6A: view

Animal Models for ACTL6A Gene

MGI Knock Outs for ACTL6A:

miRNA for ACTL6A Gene

miRTarBase miRNAs that target ACTL6A

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ACTL6A Gene

Localization for ACTL6A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACTL6A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ACTL6A Gene COMPARTMENTS Subcellular localization image for ACTL6A gene
Compartment Confidence
nucleus 5
plasma membrane 4
cytosol 3
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ACTL6A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin IDA 16217013
GO:0005634 nucleus IDA 18026119
GO:0005654 nucleoplasm TAS --
GO:0005886 plasma membrane IDA --
GO:0016514 SWI/SNF complex IDA 11078522
genes like me logo Genes that share ontologies with ACTL6A: view

Pathways for ACTL6A Gene

genes like me logo Genes that share pathways with ACTL6A: view

Gene Ontology (GO) - Biological Process for ACTL6A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003407 neural retina development IEP 18816825
GO:0006281 DNA repair IEA --
GO:0006310 DNA recombination IEA --
GO:0006325 chromatin organization TAS --
GO:0006338 chromatin remodeling IDA 11726552
genes like me logo Genes that share ontologies with ACTL6A: view

Transcripts for ACTL6A Gene

Unigene Clusters for ACTL6A Gene

Actin-like 6A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ACTL6A Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a ·
SP1: - - - - - - - - -
SP2: - - - - - - -
SP3: - - - - -
SP4: - - - -
SP5: - -
SP6: - - -
SP7: -
SP8:
SP9: -
SP10:

ExUns: 15b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for ACTL6A Gene

GeneLoc Exon Structure for
ACTL6A
ECgene alternative splicing isoforms for
ACTL6A

Expression for ACTL6A Gene

mRNA expression in normal human tissues for ACTL6A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ACTL6A Gene

SOURCE GeneReport for Unigene cluster for ACTL6A Gene Hs.435326

genes like me logo Genes that share expressions with ACTL6A: view

Orthologs for ACTL6A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ACTL6A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ACTL6A 36
  • 99.77 (n)
  • 100 (a)
ACTL6A 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ACTL6A 36
  • 93.4 (n)
  • 99.53 (a)
ACTL6A 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ACTL6A 36
  • 93.82 (n)
  • 99.52 (a)
ACTL6A 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Actl6a 36
  • 88.58 (n)
  • 98.83 (a)
Actl6a 16
Actl6a 37
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ACTL6A 37
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ACTL6A 37
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Actl6a 36
  • 88.89 (n)
  • 98.6 (a)
chicken
(Gallus gallus)
Aves ACTL6A 36
  • 85 (n)
  • 98.6 (a)
ACTL6A 37
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ACTL6A 37
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia actl6a 36
  • 80.34 (n)
  • 92.07 (a)
MGC75671 36
zebrafish
(Danio rerio)
Actinopterygii -- 36
actl6a 36
  • 77.54 (n)
  • 88.34 (a)
actl6a 37
  • 89 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008687 36
  • 55.05 (n)
  • 54.18 (a)
fruit fly
(Drosophila melanogaster)
Insecta Bap55 36
  • 58.47 (n)
  • 57.04 (a)
Bap55 37
  • 50 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea swsn-6 36
  • 54.75 (n)
  • 46.82 (a)
swsn-6 37
  • 42 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARP4 37
  • 24 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons ARP4 36
  • 53.48 (n)
  • 44.84 (a)
corn
(Zea mays)
Liliopsida Zm.3254 36
rice
(Oryza sativa)
Liliopsida Os08g0137200 36
  • 52.68 (n)
  • 43.41 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 58 (a)
ManyToMany
CSA.5416 37
  • 58 (a)
ManyToMany
Species with no ortholog for ACTL6A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ACTL6A Gene

ENSEMBL:
Gene Tree for ACTL6A (if available)
TreeFam:
Gene Tree for ACTL6A (if available)

Paralogs for ACTL6A Gene

Paralogs for ACTL6A Gene

Pseudogenes.org Pseudogenes for ACTL6A Gene

genes like me logo Genes that share paralogs with ACTL6A: view

Variants for ACTL6A Gene

Sequence variations from dbSNP and Humsavar for ACTL6A Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1132429 -- 179,581,211(+) ATTGA(A/C/G/T)ATCAG missense, reference, synonymous-codon
rs2292905 -- 179,577,057(-) AAAAT(A/G)TATTT intron-variant
rs2292906 -- 179,577,013(-) AAGTG(C/T)CCATA intron-variant
rs2292907 -- 179,576,564(-) TGAAC(G/T)AATTT intron-variant
rs3774226 -- 179,563,222(+) tcccc(C/T)tctcg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ACTL6A Gene

Variant ID Type Subtype PubMed ID
nsv437900 CNV Loss 16468122

Relevant External Links for ACTL6A Gene

HapMap Linkage Disequilibrium report
ACTL6A

Disorders for ACTL6A Gene

No disorders were found for ACTL6A Gene.

No data available for UniProtKB/Swiss-Prot for ACTL6A Gene

Publications for ACTL6A Gene

  1. Rapid and phosphoinositol-dependent binding of the SWI/SNF-like BAF complex to chromatin after T lymphocyte receptor signaling. (PMID: 9845365) Zhao K. … Crabtree G.R. (Cell 1998) 2 3 4 23
  2. Two isoforms of a human actin-related protein show nuclear localization and mutually selective expression between brain and other tissues. (PMID: 10380635) Harata M. … Mizuno S. (Biosci. Biotechnol. Biochem. 1999) 2 3 4
  3. Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis. (PMID: 10966108) Ikura T. … Nakatani Y. (Cell 2000) 3 4
  4. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  5. Recruitment of the SWI/SNF chromatin remodeling complex to steroid hormone-regulated promoters by nuclear receptor coactivator flightless-I. (PMID: 19720835) Jeong K.W. … Stallcup M.R. (J. Biol. Chem. 2009) 3 23

Products for ACTL6A Gene

Sources for ACTL6A Gene

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