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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ACTG2 Gene

protein-coding GIFtS: 63
GCID: GC02P074119

actin, gamma 2, smooth muscle, enteric

(Previous symbols: ACTL3, ACTA3)

Explore 19 diseases affiliated with
ACTG2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Actin, Gamma 2, Smooth Muscle, Enteric¹ ²		Actin-Like Protein²
ACTA3¹ ² ³ ⁵		Alpha-Actin 3²
ACTL3¹ ² ³		Alpha-Actin-3¹
ACTSG¹ ² ³		Gamma-2-Actin¹
Smooth Muscle Gamma-Actin² ³		Smooth Muscle Gamma Actin²
ACT²		Alpha-Actin-3¹
ACTE²		Gamma-2-Actin¹
Actin, Gamma-Enteric Smooth Muscle²

External Ids:	HGNC: 145¹	Entrez Gene: 72²	Ensembl: ENSG00000163017⁷	OMIM: 102545⁵	UniProtKB: P63267³

Export aliases for ACTG2 gene to outside databases

Previous GC identifers: GC02P074257 GC02P074077 GC02P074094 GC02P074031 GC02P073854

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ACTG2:

Actins are highly conserved proteins that are involved in various types of cell motility and in the maintenance of the

cytoskeleton. Three types of actins, alpha, beta and gamma, have been identified in vertebrates. Alpha actins are

found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exist

in most cell types as components of the cytoskeleton and as mediators of internal cell motility. This gene encodes

actin gamma 2; a smooth muscle actin found in enteric tissues. Alternative splicing results in multiple transcript

variants encoding distinct isoforms. Based on similarity to peptide cleavage of related actins, the mature protein of

this gene is formed by removal of two N-terminal peptides.(provided by RefSeq, Dec 2010)

UniProtKB/Swiss-Prot: ACTH_HUMAN, P63267

Function: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously

expressed in all eukaryotic cells

summary for ACTG2:

Actin is a ubiquitous globular protein that is one of the most highly-conserved proteins known. It is found

in two main states; G-actin is the globular monomeric form, whereas F-actin forms helical polymers. Both G-

and F-actin are intrinsically flexible structures - a feature vital in actin's role as a dynamic filament

network. Actin has four major functions. Firstly, F-actin polymers form microfilaments - polar intracellular

'tracks' for kinesin motor proteins, allowing the transport of vesicles, organelles and other cargo. Actin

is a component of the cytoskeleton and links to alpha-actinin, E-cadherin and beta-catenin at adherens

junctions. This gives mechanical support to cells and attaches them to each other and the extracellular

matrix. In muscle cells, actin-rich thin filaments associate with myosin-rich thick filaments to form

actomyosin myofibrils. Using energy from the hydrolysis of ATP, myofibrils undergo cyclic shortening through

actin-myosin head interactions, which represents the mechanics of muscle contraction. Finally, actin has a

role in cell motility through polymerization and depolymerization of fibrils.

Gene Wiki entry for ACTG2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_022184.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ACTG2 gene promoter:
USF1 Brachyury FOXO3 USF-1:USF-2 Roaz FOXO3b Zic1 USF-1 FOXO3a Hlf
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ACTG2 promoter sequence

Search SABiosciences Chromatin IP Primers for ACTG2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ACTG2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p13.1 Ensembl cytogenetic band: 2p13.1 HGNC cytogenetic band: 2p13.1

ACTG2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ACTG2 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P074119: view genomic region (about GC identifiers)

Start:	74,119,441 bp from pter	End:	74,146,992 bp from pter
Size:	27,552 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ACTH_HUMAN, P63267 (See protein sequence)

Recommended Name: Actin, gamma-enteric smooth muscle precursor

Size: 376 amino acids; 41877 Da

Subunit: Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a

two-stranded helix. Each actin can bind to 4 others

Subcellular location: Cytoplasm, cytoskeleton

Miscellaneous: In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha

actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins

coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility

Secondary accessions: B2R7E7 B4E315 D6W5H8 E9PG30 P12718 Q504R1 Q6FI22

Alternative splicing: 2 isoforms: P63267-1 P63267-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ACTG2: NX_P63267

Post-translational modifications:

Oxidation of Met-45 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament

depolymerization. Methionine sulfoxide is produced stereospecifically, but it is not known whether the (S)-S-oxide or

the (R)-S-oxide is produced (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P63267

ACTG2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001186822.1 NP_001606.1

ENSEMBL proteins:

ENSP00000410706 ENSP00000392894 ENSP00000386929 ENSP00000295137 ENSP00000387182

ENSP00000410020 ENSP00000386857

Reactome Protein details: P63267
Human Recombinant Protein Products for ACTG2:

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	Browse Proteins at Uscn

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	--	--
GO:0005829	cytosol	TAS	--
GO:0005856	cytoskeleton	IEA	--
GO:0071944	cell periphery	IEA	--

ACTG2 for ontologies About GeneDecksing

ACTG2 Antibody Products:

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Assay Products for ACTG2:

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	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ACTG2 for domains About GeneDecksing

3 InterPro domains/families:

IPR004001 Actin_CS

IPR004000 Actin-related

IPR020902 Actin/actin-like_CS

Graphical View of Domain Structure for InterPro Entry P63267

ProtoNet protein and cluster: P63267

UniProtKB/Swiss-Prot: ACTH_HUMAN, P63267

Similarity: Belongs to the actin family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: ACTH_HUMAN, P63267

Function: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously

expressed in all eukaryotic cells

Genatlas biochemistry entry for ACTG2:

actin,gamma 2,smooth muscle,enteric,major constituent of thin filaments

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005524	ATP binding	IEA	--

ACTG2 for ontologies About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ACTG2

miRNA Products:		OriGene 3'-UTR Clone: ACTG2 Browse MicroRNA Expression Plasmids
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		hsa-miR-33a*
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		GenScript: all cDNA clones in your preferred vector (see all 2): ACTG2 (NM_001615)
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACTG2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/38 super-pathways (see all 38) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Cytoskeleton remodeling Slit-Robo signaling

	Cytoskeleton remodeling Slit-Robo signaling	1.00			Cell adhesion_Cadherin-mediated cell adhesion	0.28
	Development_Slit-Robo signaling	0.92			Cell adhesion Cadherin-mediated cell adhesion	0.28

Actin Nucleation by ARP-WASP Complex

	Actin Nucleation by ARP-WASP Complex	1.00			RhoA Pathway	0.35
	Actin Nucleation and Branching	0.66			CDC42 Pathway	0.34

Clathrin-dependent protein traffic

	Clathrin-dependent protein traffic	1.00			wtCFTR and delta508 traffic / Clathrin coated vesicles formation (norm and CF)	0.35
	Transport_Clathrin-coated vesicle cycle	0.66

CCR3 Pathway in Eosinophils

	CCR3 Pathway in Eosinophils	1.00			Internalin Pathway	0.19
	fMLP Pathway	0.43

VEGF Family Ligands and Receptor Interactions

	VEGF Family Ligands and Receptor Interactions	1.00			CCKBR-Gastrin Stimulated Signaling	0.28
	VEGF Pathway	0.66

Pathway sources
See GeneCards unified pathways
Show all pathways

5/7 EMD Millipore Pathways for ACTG2 (see all 7)

	Clathrin-dependent protein traffic
	Cell adhesion Gap junctions
	Cell adhesion Tight junctions
	Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases
	Cytoskeleton remodeling RalA regulation pathway

5/43 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ACTG2 (see all 43)

	RhoA Pathway
	Paxillin Interactions
	Antioxidant Action of Vitamin-C
	Tec Kinases Signaling
	ITK and TCR Signaling

1 Cell Signaling Technology (CST) Pathway for ACTG2

Cytoskeletal Signaling

5/8 GeneGo (Thomson Reuters) Pathways for ACTG2 (see all 8)

	Cytoskeleton remodeling RalA regulation pathway
	Development Slit-Robo signaling
	Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases
	wtCFTR and delta508 traffic / Clathrin coated vesicles formation (norm and CF)
	Transport Clathrin-coated vesicle cycle

2 Reactome Pathways for ACTG2

	Smooth Muscle Contraction
	Muscle contraction

1 Kegg Pathway (Kegg details for ACTG2):

Vascular smooth muscle contraction

ACTG2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for ACTG2

STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

5/20 Interacting proteins for ACTG2 (P63267^{2, 3} ENSP00000295137⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 20)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GRB2	P62993²^,³, ENSP00000339007⁴	MINT-61553 I2D: score=2 STRING: ENSP00000339007
CBL	P22681³, ENSP00000264033⁴	I2D: score=1 STRING: ENSP00000264033
EMD	P50402³, ENSP00000358857⁴	I2D: score=1 STRING: ENSP00000358857
SHBG	P04278³, ENSP00000369816⁴	I2D: score=3 STRING: ENSP00000369816
KAT5	Q92993³, ENSP00000340330⁴	I2D: score=3 STRING: ENSP00000340330

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006936	muscle contraction	TAS	--

ACTG2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for ACTG2 available from Tocris Bioscience About this table

Compound	Action	CAS #
187-1, N-WASP inhibitor	Inhibits actin assembly	[380488-27-7]
Cytochalasin D	Disrupts actin filament function	[22144-77-0]
Thymosin beta4	Potent actin polymerization regulator	[77591-33-4]

Search CenterWatch for drugs/clinical trials and news about ACTG2 / ACTH

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ACTG2 gene (2 alternative transcripts):

NM_001199893.1 NM_001615.3

Unigene Cluster for ACTG2:

Actin, gamma 2, smooth muscle, enteric

Hs.516105 [show with all ESTs]

Unigene Representative Sequence: BF965163

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000438902(uc002sjw.3 uc010yrn.2) ENST00000473016 ENST00000429756

ENST00000409731 ENST00000345517 ENST00000409918(uc010fex.1) ENST00000442912

ENST00000468543 ENST00000409624(uc010fey.3)

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Additional cDNA sequence:

AK124338.1 AK129589.1 AK304523.1 AK310215.1 AK311011.1 AK311286.1 AK312955.1 BC012617.1

BC094877.1 CR536515.1 CR541794.1 X16940.1

24/30 DOTS entries (see all 30):

DT.40292926 DT.97820593 DT.100785627 DT.92473287 DT.91665702 DT.100785625 DT.100661930 DT.101963080

DT.91805461 DT.91692425 DT.419039 DT.120966040 DT.120966054 DT.75100133 DT.120966064 DT.91659413

DT.99982573 DT.100675415 DT.120966013 DT.120966025 DT.120966039 DT.120966062 DT.91988663 DT.92473434

24/382 AceView cDNA sequences (see all 382):

AA947220 AI559267 BQ019033 BM974215 AI459427 BM990208 BP343604 BM994619

AI204012 AI570980 AA299225 AW516093 BM677142 NM_001615 AW771440 AI129302

AA541720 BQ878959 BM989495 AA865194 BU687288 BU620473 CR541794 AA296688

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for ACTG2 (see all 7) About this scheme

ExUns:	1a	·	1b	^	2	^	3a	·	3b	·	3c	^	4a	·	4b	^	5	^	6a	·	6b	^	7	^	8	^	9	^	10	^	11a	·	11b	^	12
SP1:											-						-				-
SP2:					-						-						-				-
SP3:											-		-		-		-				-
SP4:					-						-				-		-		-		-		-		-
SP5:					-								-		-		-				-

ECgene alternative splicing isoforms for ACTG2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ACTG2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

ACTG2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

6 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Extraembryonic Mesoderm

Extraembryonic Blood Islands

Extraembryonic Angioblasts

Endothelium

Heart

Coronary Capillary Plexus

Vascular Smooth Muscle Cells

Epicardium, Smooth Muscle

Lateral Plate Mesoderm

Embryonic Blood Islands

Angioblasts

Endothelium

Lateral Plate Mesoderm

Embryonic Capillary Plexus

Endothelium

Skeletal Muscle

Mandibular Arch Muscles

Mononuclear Myocytes

Skeletal Muscle

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 10 LifeMap Cells

Name

Category

PureStem™ progenitor E68 (Embryonic Progenitor Cell)

PureStem™ progenitor T42 (Embryonic Progenitor Cell)

PureStem™ mesenchymal Progenitor SK11 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ mesenchymal progenitor E15 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ progenitor E69 (Embryonic Progenitor Cell)

PureStem™ progenitor T36 (Embryonic Progenitor Cell)

PureStem™ progenitor Z1 (Embryonic Progenitor Cell)

CyT49 (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

Line H9 (WA09) (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

Matrigel embedded cells (Derivation of cardio...)

See ACTG2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ACTG2

SOURCE GeneReport for Unigene cluster: Hs.516105

SABiosciences Custom PCR Arrays for ACTG2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ACTG2 Browse OriGene validated miRNA SYBR primer pairs
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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACTG2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for ACTG2 gene from 7/27 species (see all 27) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	ACTG2¹	actin, gamma 2, smooth muscle, enteric	86.08(n) 100(a)		396084 NM_205172.1 NP_990503.1
lizard (Anolis carolinensis)	Reptilia	-- ACTG2⁶	--	81(a) 100(a)	possible ortholog 1 ↔ 1	GL343721.1(263114-263356) GL343608.1(302839-317415)
zebrafish (Danio rerio)	Actinopterygii	acta1a¹	actin, alpha 1a, skeletal muscle	83.42(n) 97.87(a)		550445 NM_001017750.1 NP_001017750.1
fruit fly (Drosophila melanogaster)	Insecta	Act5C³ Act79B¹	cytoskeleton organization and biogenesis structural more³ Actin 79B¹	94(a) (best of 7)³ 80.85(n)¹ 92.29(a)¹		5C7³ 40444¹ NM_079486.3¹ NP_524210.1¹
worm (Caenorhabditis elegans)	Secernentea	act-2³	actin	94(a) (best of 5)		V(11079402-11080517) --
thale cress (Arabidopsis thaliana)	eudicotyledons	AT2G42100¹	putative actin-5	70.78(n) 78.55(a)		818810 NM_129773.1 NP_181740.1
rice (Oryza sativa)	Liliopsida	-- -- (see all 10)	actin, putative, expressed (see all 10)	88(a) 88(a) (see all 10)	many ↔ many many ↔ many (see all 10)	3(29067047-29068922) 5(354130-356637)

ENSEMBL Gene Tree for ACTG2 (if available)
TreeFam Gene Tree for ACTG2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ACTG2 gene

ACTA2² ACTRT2² ACTB² ACTR1A² ACTC1² ACTL9² ACTRT1² ACTG1²

ACTL7A² ACTBL2² ACTL7B² ACTR1B² ACTA1² ACTRT3²

18/31 SIMAP similar genes for ACTG2 using alignment to 5 protein entries: ACTH_HUMAN (see all proteins) (see all similar genes):

ACTA2 POTEF ACTC1 ACTB POTEE POTEI

POTEJ PS1TP5BP1 POTEKP ACTG1 ACT ACTBL2

ACTA1 ACTR1A ACTR1B ACTRT3 ACTRT1 ACTRT2

ACTG2 for paralogs About GeneDecksing

2 Pseudogenes.org Pseudogenes for ACTG2
PGOHUM00000244823 PGOHUM00000246338

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs17725971^1,2	C,F,H	--	74118201(+)	`GAGGAA/GGCCAG`	2	--	us2k¹		12		NA NS EA	690
rs190532578^1,2		--	74118262(+)	`TGTGCA/GTTTAG`	2	--	us2k¹		0	--	--	--	--
rs116018153^1,2		--	74118352(+)	`GGCTGA/CGGCCT`	2	--	us2k¹		1		WA	118
rs182790747^1,2		--	74118379(+)	`TTTCAA/GTAGGG`	2	--	us2k¹		0	--	--	--	--
rs145064725^1,2		--	74118531(+)	`CTCCAC/GGCCAG`	2	--	us2k¹		0	--	--	--	--
rs73948041^1,2	C,F	--	74118603(+)	`GGGCAT/CTTCTG`	2	--	us2k¹		6		WA CSA NA	245
rs13387647^1,2	C,F,A,H	--	74118611(+)	`CTGGTC/GGGGGG`	2	--	us2k¹		11		NS EA WA NA CSA	667
rs72917450^1,2	C,F	--	74118657(+)	`CATGAG/CGGAGA`	2	--	us2k¹		6		WA CSA NA	244
rs114283654^1,2	C	--	74118694(+)	`TAGCTC/TGAAGG`	2	--	us2k¹		0	--	--	--	--
rs77112249^1,2	F	--	74118796(+)	`GAAGAG/ACTGGA`	2	--	us2k¹		1		EA	120

HapMap Linkage Disequilibrium report for ACTG2 (74119441 - 74146992 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for ACTG2
2 Indels: 11177 97886

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ACTG2 for disorders           About GeneDecksing

OMIM gene information: 102545    OMIM disorders: --

19 diseases for ACTG2:    About MalaCards

legg-calve-perthes disease treacher collins syndrome gastrointestinal stromal tumor idiopathic pulmonary fibrosis

peyronie's disease peyronies disease pulmonary fibrosis diabetes mellitus

pulmonary hypertension fibrosis cholestasis sarcoma

hypertension hepatocellular carcinoma immunodeficiency carcinoma

malaria prostatitis muscular dystrophy

1 disease from the University of Copenhagen DISEASES database for ACTG2:

Legg-Calve-Perthes Disease

1 Novoseek disease relationship for ACTG2 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tumors	0	5	7777483 (1), 2174404 (1)

Human Genome Epidemiology (HuGE) Navigator: ACTG2 (1 document)

Export disorders for ACTG2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ACTG2 gene, integrated from 9 sources (see all 78):
(articles sorted by number of sources associating them with ACTG2)

Utopia: connect your pdf to the dynamic
world of online information

Structure, chromosome location, and expression of the human smooth muscle (enteric type) gamma-actin gene: evolution of six human actin genes. (PubMed id 1710027)^{1, 2, 3, 9} Miwa T.... Kakunaga T. (1991)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)^{1, 2} Hillier L.W....Wilson R.K. (2005)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
A HindIII DNA polymorphism in the human enteric type smooth muscle actin gene (ACTSG). (PubMed id 1673027)^{1, 3} Ueyama H. (1991)
The nucleotide sequence of a human smooth muscle (enteric type) gamma-actin cDNA. (PubMed id 2377475)^{1, 2} Miwa T.... Kakunaga T. (1990)
The smooth muscle gamma-actin gene is androgen responsive in prostate epithelia. (PubMed id 12450213)^{1, 9} Filmore R.A....Zimmer W.E. (2002)
Myocardin-dependent activation of the CArG box-rich s mooth muscle gamma-actin gene: preferential utilization of a single CArG elemen t through functional association with the NKX3.1 homeodomain protein. (PubMed id 19797053)^{1, 9} Sun Q....Miano J.M. (2009)
Virus assembly and plasma membrane domains: Which came first? (PubMed id 22989508)¹ Kerviel A....Muriaux D. (2013)
Role of reactive oxygen species in transforming growth factor beta1-induced alpha smooth-muscle actin and collagen production in nasal polyp-derived fibroblasts. (PubMed id 22722757)¹ Park I.H....Lee H.M. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 72	HGNC: 145	AceView: ACTG2	Ensembl:ENSG00000163017	euGenes: HUgn72
ECgene: ACTG2	Kegg: 72	H-InvDB: ACTG2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ACTG2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ACTG2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for ACTG2 gene:
Search GeneIP for patents involving ACTG2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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actin, gamma 2, smooth muscle, enteric

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ACTG2 Gene

actin, gamma 2, smooth muscle, enteric

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