Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



ACTG1 Gene

protein-coding   GIFtS: 70
GCID: GC17M079476

Actin, Gamma 1

(Previous names: deafness, autosomal dominant 20; deafness, autosomal dominant...)
(Previous symbols: ACTG, DFNA20, DFNA26)
  See ACTG1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Actin, Gamma 11 2     HEL-1762
ACTG1 2 3     Actin, Cytoplasmic 22
DFNA201 2 5     Cytoskeletal Gamma-Actin2
DFNA261 2 5     Epididymis Luminal Protein 1762
BRWS22 5     ACTB3
Deafness, Autosomal Dominant 20; Deafness, Autosomal Dominant 261     Gamma-actin3
ACT2     

External Ids:    HGNC: 1441   Entrez Gene: 712   Ensembl: ENSG000001840097   OMIM: 1025605   UniProtKB: P632613   

Export aliases for ACTG1 gene to outside databases

Previous GC identifers: GC17U990001 GC17P080051 GC17M080178 GC17M080179 GC17M077091 GC17M074925


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for ACTG1 Gene:
Actins are highly conserved proteins that are involved in various types of cell motility, and maintenance of the
cytoskeleton. In vertebrates, three main groups of actin isoforms, alpha, beta and gamma have been identified.
The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta
and gamma actins co-exist in most cell types as components of the cytoskeleton, and as mediators of internal cell
motility. Actin, gamma 1, encoded by this gene, is a cytoplasmic actin found in non-muscle cells. Mutations in
this gene are associated with DFNA20/26, a subtype of autosomal dominant non-syndromic sensorineural progressive
hearing loss. Alternative splicing results in multiple transcript variants.(provided by RefSeq, Jan 2011)

GeneCards Summary for ACTG1 Gene:
ACTG1 (actin, gamma 1) is a protein-coding gene. Diseases associated with ACTG1 include dfna20/26 nonsyndromic hearing loss and deafness, and baraitser-winter syndrome. GO annotations related to this gene include structural constituent of cytoskeleton and identical protein binding. An important paralog of this gene is ACTG2.

UniProtKB/Swiss-Prot: ACTG_HUMAN, P63261
Function: Actins are highly conserved proteins that are involved in various types of cell motility and are
ubiquitously expressed in all eukaryotic cells

summary for ACTG1 Gene:
Actin is a ubiquitous globular protein that is one of the most highly-conserved proteins known. It is found
in two main states; G-actin is the globular monomeric form, whereas F-actin forms helical polymers. Both G-
and F-actin are intrinsically flexible structures - a feature vital in actin's role as a dynamic filament
network. Actin has four major functions. Firstly, F-actin polymers form microfilaments - polar intracellular
'tracks' for kinesin motor proteins, allowing the transport of vesicles, organelles and other cargo. Actin
is a component of the cytoskeleton and links to alpha-actinin, E-cadherin and beta-catenin at adherens
junctions. This gives mechanical support to cells and attaches them to each other and the extracellular
matrix. In muscle cells, actin-rich thin filaments associate with myosin-rich thick filaments to form
actomyosin myofibrils. Using energy from the hydrolysis of ATP, myofibrils undergo cyclic shortening through
actin-myosin head interactions, which represents the mechanics of muscle contraction. Finally, actin has a
role in cell motility through polymerization and depolymerization of fibrils.

Gene Wiki entry for ACTG1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ACTG1 gene promoter:
         p53   AP-4   Meis-1b   E2F-1   E2F   c-Myb   Meis-1a   Pax-4a   TGIF   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidACTG1 promoter sequence
   Search Chromatin IP Primers for ACTG1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ACTG1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25   Ensembl cytogenetic band:  17q25.3   HGNC cytogenetic band: 17q25

ACTG1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ACTG1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M079476:  view genomic region     (about GC identifiers)

Start:
79,476,997 bp from pter      End:
79,490,873 bp from pter
Size:
13,877 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: ACTG_HUMAN, P63261 (See protein sequence)
Recommended Name: Actin, cytoplasmic 2  
Size: 375 amino acids; 41793 Da
Subunit: Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a
two-stranded helix. Each actin can bind to 4 others
Miscellaneous: In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The
alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and
gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell
motility
Secondary accessions: A8K7C2 P02571 P14104 P99022 Q5U032 Q96E67

Explore the universe of human proteins at neXtProt for ACTG1: NX_P63261

Explore proteomics data for ACTG1 at MOPED

Post-translational modifications: 

  • The methylhistidine determined by Bienvenut et al is assumed to be the tele-methylhistidine isomer by similarity
    to the mouse ortholog1
  • Oxidation of Met-44 and Met-47 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin
    filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by
    MSRB1 and MSRB2, which promote actin repolymerization (By similarity)1
  • Monomethylation at Lys-84 (K84me1) regulates actin-myosin interaction and actomyosin-dependent processes.
    Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow
    ingression during cytokinesis and cell migration1
  • Ubiquitination2 at Lys18, Lys50, Lys61, Lys84, Lys113, Lys191, Lys213, Lys215, Lys291, Lys315,
                                 Lys326, Lys328
  • Modification sites at PhosphoSitePlus

  • See ACTG1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001186883.1  NP_001605.1  

    ENSEMBL proteins: 
     ENSP00000331514   ENSP00000458435   ENSP00000458162   ENSP00000459124   ENSP00000461672  
     ENSP00000462823   ENSP00000461407   ENSP00000460464   ENSP00000459119   ENSP00000460660  
     ENSP00000466346  
    Reactome Protein details: P63261

    ACTG1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for ACTG1
    OriGene Protein Over-expression Lysate for ACTG1
    OriGene MassSpec for ACTG1
    OriGene Custom Protein Services for ACTG1
    GenScript Custom Purified and Recombinant Proteins Services for ACTG1
    Novus Biologicals ACTG1 Protein
    Novus Biologicals ACTG1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for ACTG1
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for ACTG1 

    ACTG1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of ACTG1
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for ACTG1 
    OriGene Antibodies for ACTG1
    OriGene Custom Antibody Services for ACTG1
    Novus Biologicals ACTG1 Antibodies
    Abcam antibodies for ACTG1
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for ACTG1
    LSBio Antibodies in human, mouse, rat for ACTG1

    ACTG1 Assay Products:

    EMD Millipore Kits and Assays for the Analysis of ACTG1
    OriGene Custom Assay Services for ACTG1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ACTG1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for ACTG1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    3 InterPro protein domains:
     IPR020902 Actin/actin-like_CS
     IPR004001 Actin_CS
     IPR004000 Actin-related

    Graphical View of Domain Structure for InterPro Entry P63261

    ProtoNet protein and cluster: P63261

    UniProtKB/Swiss-Prot: ACTG_HUMAN, P63261
    Similarity: Belongs to the actin family


    Find genes that share domains with ACTG1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ACTG_HUMAN, P63261
    Function: Actins are highly conserved proteins that are involved in various types of cell motility and are
    ubiquitously expressed in all eukaryotic cells

         Genatlas biochemistry entry for ACTG1:
    actin,gamma,cytoplasmic 1 major constituent of microfilaments

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005200structural constituent of cytoskeleton IC16130169
    GO:0005515protein binding IPI16189514
    GO:0005524ATP binding IEA--
    GO:0042802identical protein binding IPI16189514
         
    Find genes that share ontologies with ACTG1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ACTG1:
     Increased focal adhesion (FA)  

         7 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Actg1):
     behavior/neurological  digestive/alimentary  growth/size/body  hearing/vestibular/ear  mortality/aging 
     muscle  nervous system 

    Find genes that share phenotypes with ACTG1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Actg1tm1.1Erv for ACTG1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ACTG1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ACTG1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ACTG1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ACTG1

    miRNA
    Products:
        
    miRTarBase miRNAs that target ACTG1:
    hsa-mir-197-3p (MIRT048069), hsa-mir-1180-3p (MIRT035953), hsa-mir-99b-3p (MIRT038520), hsa-mir-423-5p (MIRT038157), hsa-mir-193b-3p (MIRT041197), hsa-mir-34a-5p (MIRT047350), hsa-mir-1226-3p (MIRT036487), hsa-mir-877-3p (MIRT037047), hsa-mir-222-3p (MIRT046782), hsa-mir-877-5p (MIRT037360), hsa-mir-10b-5p (MIRT047480), hsa-mir-652-3p (MIRT039560), hsa-mir-935 (MIRT036673), hsa-mir-16-5p (MIRT031957), hsa-let-7b-5p (MIRT001852), hsa-mir-149-5p (MIRT045649), hsa-mir-99b-5p (MIRT044186), hsa-mir-342-3p (MIRT043711), hsa-mir-1307-3p (MIRT035814), hsa-mir-320a (MIRT044776), hsa-mir-1227-3p (MIRT036397), hsa-mir-744-5p (MIRT037421), hsa-mir-769-3p (MIRT039133), hsa-mir-10a-5p (MIRT047724), hsa-mir-331-3p (MIRT043297), hsa-mir-221-3p (MIRT046971), hsa-mir-361-5p (MIRT044076), hsa-mir-326 (MIRT043651)

    Block miRNA regulation of human, mouse, rat ACTG1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ACTG1 (see all 16):
    hsa-miR-485-5p hsa-miR-3194-5p hsa-miR-300 hsa-miR-10b hsa-miR-624 hsa-miR-512-3p hsa-miR-103a hsa-miR-105
    SwitchGear 3'UTR luciferase reporter plasmidACTG1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ACTG1
    Predesigned siRNA for gene silencing in human, mouse, rat ACTG1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ACTG1

    Clone
    Products:
         
    OriGene clones in human, mouse for ACTG1 (see all 10)
    OriGene ORF clones in mouse, rat for ACTG1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ACTG1 (NM_001614)
    Sino Biological Human cDNA Clone for ACTG1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ACTG1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACTG1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ACTG1
    Browse ESI BIO Cell Lines and PureStem Progenitors for ACTG1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACTG1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    ACTG_HUMAN, P63261: Cytoplasm, cytoskeleton
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    extracellular5
    cytosol4
    nucleus3
    mitochondrion2
    plasma membrane2
    endoplasmic reticulum1
    golgi apparatus1

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA--
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--
    GO:0005856cytoskeleton TAS16130169
    GO:0015629actin cytoskeleton ----

    Find genes that share ontologies with ACTG1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for ACTG1 About   (see all 66)  
    See pathways by source

    SuperPathContained pathways About
    1Development Slit Robo signaling
    Development Slit Robo signaling0.92
    Pathogenic Escherichia coli infection0.41
    Cytoskeleton remodeling Slit Robo signaling0.92
    Neurophysiological process Receptor mediated axon growth repulsion0.41
    Pathogenic Escherichia coli infection0.43
    2Hypertrophic cardiomyopathy (HCM)
    Hypertrophic cardiomyopathy (HCM)0.75
    Arrhythmogenic right ventricular cardiomyopathy (ARVC)0.54
    Dilated cardiomyopathy0.75
    Arrhythmogenic right ventricular cardiomyopathy0.54
    3Clathrin dependent protein traffic
    Clathrin dependent protein traffic0.66
    wtCFTR and delta508 traffic Clathrin coated vesicles formation norm and CF 0.35
    Transport Clathrin coated vesicle cycle0.66
    4Focal adhesion
    Focal adhesion0.65
    Focal Adhesion0.65
    5Regulation of actin cytoskeleton
    Regulation of actin cytoskeleton0.57
    Regulation of Actin Cytoskeleton0.57


    Find genes that share SuperPaths with ACTG1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ACTG1 (see all 43)
        RhoA Pathway
    Paxillin Interactions
    Antioxidant Action of Vitamin-C
    Tec Kinases Signaling
    ITK and TCR Signaling

    1 Cell Signaling Technology (CST) Pathway for ACTG1
        Cytoskeletal Signaling

    Selected GeneGo (Thomson Reuters) Pathways for ACTG1 (see all 27)
        Immune response CD16 signaling in NK cells
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
    Cell adhesion Endothelial cell contacts by non-junctional mechanisms
    Cytoskeleton remodeling Keratin filaments
    Development Slit-Robo signaling

    Selected BioSystems Pathways for ACTG1 (see all 6)
        Myometrial Relaxation and Contraction Pathways
    Focal Adhesion
    Regulation of Actin Cytoskeleton
    Striated Muscle Contraction
    Arrhythmogenic right ventricular cardiomyopathy


    Selected Reactome Pathways for ACTG1 (see all 8)
        Recycling pathway of L1
    Gap junction degradation
    Cell-extracellular matrix interactions
    Interaction between L1 and Ankyrins
    Adherens junctions interactions


    Selected Kegg Pathways  (Kegg details for ACTG1) (see all 21):
        Rap1 signaling pathway
    Phagosome
    Hippo signaling pathway
    Focal adhesion
    Adherens junction

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ACTG1
    Interactions:

        Search GeneGlobe Interaction Network for ACTG1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ACTG1 (P632611, 2, 3 ENSP000003315144) via UniProtKB, MINT, STRING, and/or I2D (see all 768)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628052, 3MINT-7899812 I2D: score=2 
    HIST1H4BP628052, 3MINT-7899812 I2D: score=2 
    HIST1H4CP628052, 3MINT-7899812 I2D: score=2 
    HIST1H4DP628052, 3MINT-7899812 I2D: score=2 
    HIST1H4EP628052, 3MINT-7899812 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001895retina homeostasis IEP--
    GO:0006928cellular component movement TAS16130169
    GO:0007411axon guidance TAS--
    GO:0034329cell junction assembly TAS--
    GO:0034332adherens junction organization TAS--

    Find genes that share ontologies with ACTG1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for ACTG1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    CK 666Arp2/3 inhibitor; inhibits actin polymerization[442633-00-3]
    Latrunculin AInhibitor of actin assembly and polymerization[76343-93-6]
    Cytochalasin DDisrupts actin filament function[22144-77-0]
    JasplakinolideStabilizes F-actin; promotes actin polymerization[102396-24-7]
    Thymosin beta4Potent actin polymerization regulator[77591-33-4]

    9 Novoseek inferred chemical compound relationships for ACTG1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    actb 95 45 18191039 (3), 16777070 (3), 15720708 (3), 19587781 (3) (see all 24)
    glyceraldehyde 3-phosphate 53.9 7 18191039 (1), 16777070 (1), 20113474 (1), 8367299 (1) (see all 7)
    jasplakinolide 50.4 1 15342343 (1)
    cytochalasin d 41 1 1577858 (1)
    hypoxanthine 38.6 4 18191039 (1), 16777070 (1), 18983665 (1), 17257226 (1)
    pip2 34.1 2 8547642 (1), 8780652 (1)
    calcium 0 2 20308063 (2)
    superoxide 0 1 8226538 (1)
    dexamethasone 0 8 18191039 (2), 16777070 (2), 7895671 (1)



    Find genes that share compounds with ACTG1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for ACTG1 gene (2 alternative transcripts): 
    NM_001199954.1  NM_001614.3  

    Unigene Cluster for ACTG1:

    Actin, gamma 1
    Hs.514581  [show with all ESTs]
    Unigene Representative Sequence: BF569066
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000331925(uc002kag.3 uc002kal.2) ENST00000573283(uc002kak.2)
    ENST00000575842 ENST00000576917 ENST00000574671 ENST00000576209 ENST00000575087
    ENST00000576544 ENST00000572105 ENST00000576214 ENST00000571691 ENST00000575994
    ENST00000575659 ENST00000571721 ENST00000570382
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ACTG1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ACTG1 (see all 16):
    hsa-miR-485-5p hsa-miR-3194-5p hsa-miR-300 hsa-miR-10b hsa-miR-624 hsa-miR-512-3p hsa-miR-103a hsa-miR-105
    SwitchGear 3'UTR luciferase reporter plasmidACTG1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ACTG1
    Predesigned siRNA for gene silencing in human, mouse, rat ACTG1
    Clone
    Products:
         
    OriGene clones in human, mouse for ACTG1 (see all 10)
    OriGene ORF clones in mouse, rat for ACTG1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ACTG1 (NM_001614)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ACTG1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACTG1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ACTG1
    OriGene qSTAR qPCR primer pairs in human, mouse for ACTG1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ACTG1
      QuantiTect SYBR Green Assays in human, mouse, rat ACTG1
      QuantiFast Probe-based Assays in human, mouse, rat ACTG1

    Additional mRNA sequence: 

    AK291937.1 AK304637.1 BC000292.2 BC001920.1 BC004223.2 BC007442.2 BC009544.1 BC009848.2 
    BC010417.2 BC010999.2 BC012050.1 BC015005.1 BC015695.2 BC015779.1 BC017450.1 BC018774.1 
    BC018861.2 BC023548.2 BC039144.1 BC053572.1 BC063495.1 BT019856.1 M16247.1 NR_037688.1 
    X04098.1 

    Selected DOTS entries (see all 239):

    DT.100750836  DT.101987720  DT.92033430  DT.100750698  DT.100750752  DT.100750646  DT.101986577  DT.100750686 
    DT.100750381  DT.91941217  DT.75154030  DT.87009547  DT.100750483  DT.100750945  DT.100750953  DT.98083489 
    DT.91960848  DT.100750615  DT.100855754  DT.100750681  DT.100750792  DT.91733472  DT.87002754  DT.100750770 

    Selected AceView cDNA sequences (see all 231):

    CR611108 CR604033 BC000292 CR602227 CR603981 CR610785 CR604825 CR612408 
    CR609271 CR602348 BC023548 CR599678 CR603085 CR625920 CR604531 X04098 
    CR622438 CR606241 CR619574 CR599830 CR614891 CR621646 CR611432 CR598395 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ACTG1 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7a · 7b
    SP1:                    -                                   -     -                       -                           
    SP2:                    -                                   -     -                                                   
    SP3:                                                        -     -                                                   
    SP4:                                                        -                             -                           
    SP5:                    -           -     -                 -     -                                                   


    ECgene alternative splicing isoforms for ACTG1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    ACTG1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTAGCCTCAC
    ACTG1 Expression
    About this image


    ACTG1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Heart (Cardiovascular System)
             Atrioventricular Canal Cells Atrioventricular Canal
     
     Inner Cell Mass (Early Embryonic Tissues)
             Inner Cell Mass Cells Inner Cell Mass
     
     Endoderm (Gastrulation Derivatives)
             Endoderm-like cells
     
     Tonsil (Hematopoietic System)
    ACTG1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ACTG1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.514581
        Custom PCR Arrays for ACTG1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ACTG1
    OriGene qSTAR qPCR primer pairs in human, mouse for ACTG1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ACTG1
    QuantiTect SYBR Green Assays in human, mouse, rat ACTG1
    QuantiFast Probe-based Assays in human, mouse, rat ACTG1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACTG1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ACTG1 gene from Selected species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Actg11 , 5 actin, gamma, cytoplasmic 11, 5 89.87(n)1
    100(a)1
      11 (84.07 cM)5
    114651  NM_009609.21  NP_033739.11 
     1203456905 
    chicken
    (Gallus gallus)
    Aves ACTG11 Actin, gamma 1 85.92(n)
    99.2(a)
      415296  NM_001007824.1  NP_001007825.1 
    lizard
    (Anolis carolinensis)
    Reptilia ACTG16
    actin, gamma 1
    100(a)
    1 ↔ 1
    2(98722875-98724624)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia BC064155.12   -- 82.68(n)    BC064155.1 
    zebrafish
    (Danio rerio)
    Actinopterygii actb21 actin, beta 2 87.56(n)
    98.67(a)
      57935  NM_181601.4  NP_853632.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta Act5C1 , 3 cytoskeleton organization and
    biogenesis structural more3
    Actin 5C1
    98(a)
    (best of 7)3
    85.83(n)1
    98.13(a)1
      5C73
    315211  NM_001014726.21  NP_001014726.11 
    worm
    (Caenorhabditis elegans)
    Secernentea act-23
    act-41
    actin3
    act-41
    97(a)
    (best of 5)3
    82.71(n)1
    97.06(a)1
      V(11079402-11080517)3
    1807671  NM_076440.61  NP_508841.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ACT11 ACT1 73.33(n)
    89.07(a)
      850504   NP_116614.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ACT21 ACT2 74.26(n)
    87.13(a)
      821411  NM_112764.3  NP_188508.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g07181001 Os03g0718100 79(n)
    90.62(a)
      4333919  NM_001057621.1  NP_001051086.1 


    ENSEMBL Gene Tree for ACTG1 (if available)
    TreeFam Gene Tree for ACTG1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for ACTG1 gene
    ACTG22  ACTA22  ACTRT22  ACTR1A2  ACTB2  ACTC12  ACTRT12  ACTBL22  
    ACTR1B2  ACTA12  ACTRT32  
    Selected SIMAP similar genes for ACTG1 using alignment to 9 protein entries:     ACTG_HUMAN (see all proteins) (see all similar genes):
    ACTB    PS1TP5BP1    POTEF    ACTC1    ACTA2    ACTBL2
    POTEE    POTEI    POTEJ    POTEM    POTEKP    ACTG2
    ACT    ACTA1    ACTR1A    ACTR1B    ACTRT3    ACTRT1

    Find genes that share paralogs with ACTG1           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for ACTG1 (see all 30)
    PGOHUM00000238830 PGOHUM00000246738 PGOHUM00000246771 PGOHUM00000246896 PGOHUM00000262297


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for ACTG1 (see all 438)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs289991121,2,,4
    CDeafness, autosomal dominant, 20 (DFNA20)4 pathogenic180591126(-) GACCAC/TCTTCA 5 T I mis1 ese30--------
    rs2676066311,2,,4
    CDeafness, autosomal dominant, 20 (DFNA20)4 pathogenic180591317(-) GCTACA/GAGCTG 5 K E mis10--------
    rs115491901,2,,4
    CBaraitser-Winter syndrome 2 (BRWS2)4 pathogenic180591634(-) CGTGGC/TCATCC 5 A V mis1 ese30--------
    rs2676066301,2,,4
    CDeafness, autosomal dominant, 20 (DFNA20)4 pathogenic180591960(-) GAGAAC/GATGAC 5 N K mis10--------
    rs289991111,2,,4
    CDeafness, autosomal dominant, 20 (DFNA20)4 pathogenic180592048(-) CCACAC/TCTTCT 5 T I mis1 ese30--------
    VAR_0324364
    Deafness, autosomal dominant, 20 (DFNA20)4--see VAR_0324362 P L mis40--------
    VAR_0324384
    Deafness, autosomal dominant, 20 (DFNA20)4--see VAR_0324382 P A mis40--------
    VAR_0324354
    Deafness, autosomal dominant, 20 (DFNA20)4--see VAR_0324352 K M mis40--------
    VAR_0324394
    Deafness, autosomal dominant, 20 (DFNA20)4--see VAR_0324392 V A mis40--------
    rs1048945471,2
    Cpathogenic180590757(-) CATCGC/TCCACC 5 A V mis10--------

    HapMap Linkage Disequilibrium report for ACTG1 (79476997 - 79490873 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ACTG1 (see all 17):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833568CNV Loss17160897
    dgv3318n71CNV Loss21882294
    nsv457973CNV Loss19166990
    dgv3331n71CNV Loss21882294
    dgv3332n71CNV Loss21882294
    dgv3324n71CNV Loss21882294
    dgv3330n71CNV Loss21882294
    nsv909105CNV Loss21882294
    nsv909000CNV Loss21882294
    nsv828128CNV Loss20364138

    Human Gene Mutation Database (HGMD): ACTG1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ACTG1
    DNA2.0 Custom Variant and Variant Library Synthesis for ACTG1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 102560   
    OMIM disorders: 604717  614583  
    UniProtKB/Swiss-Prot: ACTG_HUMAN, P63261
  • Deafness, autosomal dominant, 20 (DFNA20) [MIM:604717]: A form of non-syndromic sensorineural hearing
    loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to
    the brain, or the area of the brain that receives sound information. Note=The disease is caused by mutations
    affecting the gene represented in this entry
  • Baraitser-Winter syndrome 2 (BRWS2) [MIM:614583]: A rare developmental disorder characterized by the
    combination of congenital ptosis, high-arched eyebrows, hypertelorism, ocular colobomata, and a brain
    malformation consisting of anterior-predominant lissencephaly. Other typical features include postnatal short
    stature and microcephaly, intellectual disability, seizures, and hearing loss. Note=The disease is caused by
    mutations affecting the gene represented in this entry

  • 10 diseases for ACTG1:    
    About MalaCards
    dfna20/26 nonsyndromic hearing loss and deafness    baraitser-winter syndrome    deafness, autosomal dominant 20/26    baraitser-winter syndrome 2
    baraitser-winter syndrome 1    aland island eye disease    usher syndrome type i    deafness, autosomal dominant 4b
    charcot-marie-tooth disease type 2    glomus tumor

    3 diseases from the University of Copenhagen DISEASES database for ACTG1:
    Cancer     Acquired immunodeficiency syndrome     Vascular disease

    Find genes that share disorders with ACTG1           About GenesLikeMe

    6 Novoseek inferred disease relationships for ACTG1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hearing loss sensorineural 22.5 1 18804074 (1)
    shock 9.5 6 20479917 (1), 10882332 (1), 15910747 (1), 15989238 (1) (see all 6)
    metastasis 0 1 16867268 (1)
    tumors 0 2 9731740 (1), 10882332 (1)
    carcinoma 0 2 18540438 (1), 16867268 (1)
    cancer 0 1 9538132 (1)

    Genetic Association Database (GAD): ACTG1
    Human Genome Epidemiology (HuGE) Navigator: ACTG1 (1 document)
    Tumor Gene Database (TGDB): ACTG1

    Export disorders for ACTG1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for ACTG1 gene, integrated from 10 sources (see all 303):
    (articles sorted by number of sources associating them with ACTG1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A mutation in the gamma actin 1 (ACTG1) gene causes autosomal dominant hearing loss (DFNA20/26). (PubMed id 14684684)1, 2, 3, 9 van Wijk E.... Kremer H. (J. Med. Genet. 2003)
    2. Mutations in the gamma-actin gene (ACTG1) are associated with dominant progressive deafness (DFNA20/26). (PubMed id 13680526)1, 2, 4, 9 Zhu M.... Friderici K.H. (Am. J. Hum. Genet. 2003)
    3. Novel ACTG1 mutation causing autosomal dominant non-syndromic hearing impairment in a Chinese family. (PubMed id 18804074)1, 2, 9 Liu P.... Liu M. (J. Genet. Genomics 2008)
    4. De novo mutations in the actin genes ACTB and ACTG1 cause Baraitser- Winter syndrome. (PubMed id 22366783)1, 2 Riviere J.B....Dobyns W.B. (Nat. Genet. 2012)
    5. In vivo and in vitro effects of two novel gamma-actin (ACTG1) mutations that cause DFNA20/26 hearing impairment. (PubMed id 19477959)1, 2 Morin M.... Moreno-Pelayo M.A. (Hum. Mol. Genet. 2009)
    6. A novel missense mutation in ACTG1 causes dominant deafness in a Norwegian DFNA20/26 family, but ACTG1 mutations are not frequent among families with hereditary hearing impairment. (PubMed id 16773128)1, 2 Rendtorff N.D.... Tranebjaerg L. (Eur. J. Hum. Genet. 2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (Nat. Biotechnol. 2003)
    9. Structure, chromosome location, and expression of the human gamma- actin gene: differential evolution, location, and expression of the cytoskeletal beta- and gamma-actin genes. (PubMed id 2837653)1, 2 Erba H.P.... Gunning P. (Mol. Cell. Biol. 1988)
    10. Gamma-actin: unusual mRNA 3'-untranslated sequence conservation and amino acid substitutions that may be cancer related. (PubMed id 3472224)1, 2 Chou C.C.... Salser W.A. (Proc. Natl. Acad. Sci. U.S.A. 1987)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 71 HGNC: 144 AceView: ACTG1 Ensembl:ENSG00000184009 euGenes: HUgn71
    ECgene: ACTG1 Kegg: 71 H-InvDB: ACTG1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for ACTG1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ACTG1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for ACTG1 gene:
    Search GeneIP for patents involving ACTG1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Small Molecules at EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     EMD Millipore Kits and Assays for the Analysis of ACTG1
     EMD Millipore Mono- and Polyclonal Antibodies for the study of ACTG1
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for ACTG1   OriGene RNAi products in human, mouse, rat for ACTG1  
     OriGene qPCR primer pairs and template standards for ACTG1   OriGene Protein Over-expression Lysate for ACTG1  
     OriGene MassSpec something-or-other for ACTG1   OriGene clones in human, mouse for ACTG1  
     OriGene qSTAR qPCR primer pairs in human, mouse for ACTG1   OriGene Purified Protein for ACTG1  
     OriGene ORF clones in mouse, rat for ACTG1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ACTG1   OriGene Custom Protein Services for ACTG1  

     
     
     Block miRNA regulation of human, mouse, rat ACTG1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ACTG1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ACTG1 Predesigned siRNA for gene silencing in human, mouse, rat ACTG1
     QuantiFast Probe-based Assays in human, mouse, rat ACTG1 QuantiTect SYBR Green Assays in human, mouse, rat ACTG1
     Custom PCR Arrays for ACTG1 Search Chromatin IP Primers for ACTG1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ACTG1  Search GeneGlobe Interaction Network for ACTG1
     Regulatory tfbs in ACTG1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for ACTG1 GenScript cDNA clones with any tag delivered in your preferred vector for ACTG1
     GenScript Custom Assay Services for ACTG1 GenScript Custom overexpressing Cell Line Services for ACTG1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for ACTG1 

     Tocris compounds for ACTG1
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for ACTG1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     ACTG1 antibodies
     ACTG1 proteins
     ACTG1 lysates
     Antibodies for ACTG1
     See all of Abcam's Antibodies, Kits and Proteins for ACTG1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for ACTG1
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for ACTG1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACTG1
     SwitchGear 3'UTR luciferase reporter plasmids for ACTG1
     SwitchGear Promoter luciferase reporter plasmids for ACTG1
     ThermoFisher Antibodies for ACTG1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACTG1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ACTG1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ACTG1
     LSBio Antibodies in human, mouse, rat for ACTG1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for ACTG1
      Search eBioscience for proteins for ACTG1
      Search eBioscience for elisas for ACTG1
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ACTG1 gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4