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ACTC1 Gene

protein-coding GIFtS: 56

GC15M032870

actin, alpha, cardiac muscle 1
(Previous names: actin, alpha, cardiac muscle )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: ACTC)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
ACTC ^², ³
CMD1R ^¹, ², ⁵
CMH11 ^², ⁵

Descriptions
Alpha-cardiac actin ^³
actin, alpha, cardiac muscle ^¹
actin, alpha, cardiac muscle 1 ^²
cardiac muscle alpha actin 1 ^²

External Ids
HGNC: 143¹
Entrez Gene: 70²
UniProtKB: P68032³
Ensembl: ENSG00000159251⁷

Search outside databases for aliases for ACTC1 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ACTC1:

Actins are highly conserved proteins that are involved in various types of cell motility.

Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of

a two-stranded helix. Each actin can bind to four others. The protein encoded by this gene belongs

to the actin family which is comprised of three main groups of actin isoforms, alpha, beta, and

gamma. The alpha actins are found in muscle tissues and are a major constituent of the contractile

apparatus. Defects in this gene have been associated with idiopathic dilated cardiomyopathy (IDC)

and familial hypertrophic cardiomyopathy (FHC). [provided by RefSeq]

UniProtKB/Swiss-Prot: ACTC_HUMAN, P68032

Function: Actins are highly conserved proteins that are involved in various types of cell motility

and are ubiquitously expressed in all eukaryotic cells

Gene Wiki entry for ACTC1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q11-q14 Ensembl cytogenetic band: 15q14 HGNC cytogenetic band: 15q11-q14

ACTC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15M032870: (about GC identifiers)

Start:	32,867,589 bp from pter
End:	32,875,219 bp from pter
Size:	7,631 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000015.8 NT_010194.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ACTC_HUMAN, P68032 (See protein sequence)

Recommended Name: Actin, alpha cardiac muscle 1

Size: 377 amino acids; 42019 Da

Subunit: Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the

form of a two-stranded helix. Each actin can bind to 4 others

Subcellular location: Cytoplasm, cytoskeleton

Miscellaneous: In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been

identified. The alpha actins are found in muscle tissues and are a major constituent of the

contractile apparatus. The beta and gamma actins coexist in most cell types as components of the

cytoskeleton and as mediators of internal cell motility

Secondary accessions: P04270

REFSEQ proteins: NP_005150.1

ENSEMBL proteins:

ENSP00000290378

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich AQUA Peptides for ACTC1
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Pan Muscle Alpha Actin , Actin, muscle Actin, alpha sarcomeric Actin)
	Human Recombinant Proteins from Abnova (ACTC)

OriGene Purified Recombinant Human Protein: ACTC1

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--
GO:0005856	cytoskeleton	IEA	--
GO:0031674	I band	ISS	--
GO:0042643	actomyosin, actin part	IDA	16611632

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Antibodies for ACTC1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for ACTC1
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Pan Muscle Alpha Actin , Actin, muscle Actin, alpha sarcomeric Actin), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for ACTC1

Assays for ACTC1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P68032

ProtoNet protein and cluster: P68032

UniProtKB/Swiss-Prot: ACTC_HUMAN, P68032

Similarity: Belongs to the actin family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ACTC1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005159

Applied Biosystems Silencer® siRNAs for ACTC1

Sigma-Aldrich siRNA for ACTC1

Sigma-Aldrich shRNA for ACTC1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ACTC1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_005159
Myc/DDK tagged cDNA clone in CMV expression vector: NM_005159
untagged cDNA clone in CMV expression vector: NM_005159

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_005159

UniProtKB/Swiss-Prot: ACTC_HUMAN, P68032

Function: Actins are highly conserved proteins that are involved in various types of cell motility

and are ubiquitously expressed in all eukaryotic cells

7 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Actc1):

	growth/size	homeostasis/metabolism	lethality-postnatal	lethality-prenatal/perinatal
muscle	normal

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0005515	protein binding	IEA	--
GO:0005524	ATP binding	IDA	16611632
GO:0016887	ATPase activity	IDA	16611632 17765196
GO:0017022	myosin binding	IPI	16611632

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/17 Sigma-Aldrich "Your Favorite Gene" Pathways for ACTC1 (Your Favorite Gene powered by Ingenuity) (see all 17 )

Integrin Signaling
Caveolar-mediated Endocytosis
Purine Metabolism
Fc&gamma
Agrin Interactions at Neuromuscular Junction

GeneDecks ACTC1 for the pathways selected above

About GeneDecksing

5/42 Interacting proteins for ACTC1 (ENSP00000290378³ P68032²) via UniProtKB, MINT, and/or STRING (see all 42 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TRIM63	Q969Q1²	MINT-6503620
TPM1	ENSP00000350667³	STRING (score=.967)
TNNT2	ENSP00000356286³	STRING (score=.94)
MYL2	ENSP00000228841³	STRING (score=.931)
MYBPC3	ENSP00000256993³	STRING (score=.924)

About this table

5/7 Gene Ontology (GO) biological process terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006915	apoptosis	ISS	--
GO:0030048	actin filament-based movement	IDA	16611632
GO:0030240	muscle thin filament assembly	ISS	--
GO:0031032	actomyosin structure organization	ISS	--
GO:0055003	cardiac myofibril assembly	ISS	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for ACTC1

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ACTC1
10/20 Novoseek chemical compound relationships for ACTC1 gene (see all 20 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
mucicarmine	61.08	2	11211614 (1), 11858401 (1)
s 100	60.85	2	10564387 (1), 16859566 (1)
progesterone	58.35	47	10227006 (2), 9308729 (1), 9422311 (1), 12090595 (1) (see all 45)
hematoxylin	55.24	6	15307213 (1), 15807305 (1), 16883460 (1), 17240306 (1) (see all 6)
reticulin	54.05	4	11858401 (1), 14565567 (1), 15363323 (1), 18459138 (1)
nash	32.98	5	18802068 (1), 19330863 (1)
orcein	31.16	1	15363323 (1)
matrigel	15.21	1	11710645 (1)
b 723	14.91	1	7678320 (1)
glycogen	14.84	1	11048812 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ACTC1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005159

Sigma-Aldrich siRNA for ACTC1

Sigma-Aldrich shRNA for ACTC1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_005159

REFSEQ mRNAs for ACTC1 gene:

NM_005159.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_005159

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005159
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_005159
                                 untagged cDNA clone in CMV expression vector: NM_005159

Additional cDNA sequence:

AK129892.1 AK129902.1 AK290616.1 BC009978.2 CR541795.1

11 DOTS entries:

DT.75138650 DT.87009325 DT.75162336 DT.121040859 DT.97858741 DT.100785624 DT.121040827 DT.87017230

DT.92420061 DT.95214207 DT.102838330

24/241 AceView cDNA sequences (see all 241 ):

C04447 AA330934 AA330630 BM847198 AA968481 AA775604 BX502865 C04959

W78033 AA953615 AJ708424 BP375166 N70639 AJ712314 T19640 AK129902

AA347523 CA976073 BU622616 AA039993 AA346915 AK129892 AJ710388 BM848240

highest scoring ESTs for ACTC1:

AK129892 AK129902 BC009978 BF307690 BG699191 BM764026 BM845863 BM847198 BM848240 BM849456

Unigene Cluster for ACTC1:

Actin, alpha, cardiac muscle 1

Hs.118127 [show with all ESTs]

Unigene Representative Sequence: NM_005159

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000290378

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ACTC1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ACTC1

¹ / ² / ³

4 probe-sets matching ACTC1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
53330_at²^{, 3}	U95-C	1	1.00	1.00	0.59	0.98	AI222203	0.40	1.00	0.76	1
39063_at²^{, 3}	U95-A	2	1.00	0.97	0.99	1.07	J00073	0.20	1.00	0.72	1
205132_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_005159	0.60	1.00	0.82	1
205132_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks ACTC1 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.118127

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ACTC1 gene from 5/14 species (see all 14 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ACTC1¹	--	actin, alpha, cardiac muscle 1	92.4(n) 100(a)	478250 XM_535424.2 XP_535424.1
chimpanzee (Pan troglodytes)	ACTC1¹	--	actin, alpha, cardiac muscle 1	99.65(n) 100(a)	453307 XM_001135141.1 XP_001135141.1
cow (Bos taurus)	ACTC1¹	--	actin, alpha, cardiac muscle 1	93.19(n) 100(a)	533219 NM_001034585.1 NP_001029757.1
rat (Rattus norvegicus)	Actc1¹	--	actin, alpha, cardiac muscle 1	90.8(n) 100(a)	29275 NM_019183.1 NP_062056.1
mouse (Mus musculus)	Actc1^{1, 5}	2 (64.00 cM)⁵	actin, alpha, cardiac muscle 1^{1, 5}	92.31(n)¹ 100(a)¹	11464¹ NM_009608.2¹ NP_033738.1¹ AK014303⁵ AK014307⁵ (see all 24)

About this table Species with no ortholog for ACTC1

ENSEMBL Gene Tree for ACTC1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ACTC1 gene

ACTA2² ACTG2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/58 NCBI SNPs in ACTC1 are shown (see all 58 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 65)

AB	SNP ID	Valid	Chr 15 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs670957^1,2	A,C,F,H,O	32876724(+)	`GTCTCA/GTGAAA`	1	--	ng3¹		21		NS EU EA WA NA	1570
	rs533021^1,2	A,C,F,H,O	32868223(+)	`AACTCT/CAAACT`	1	--	ut3¹		5		MN EU EA WA	602
	rs1370154^1,2	A,C,F,H	32869517(-)	`TTAAGG/ATTTAG`	1	--	ut3¹		8		EA EU WA NA	782
	rs496394^1,2	A,C,F	32875495(+)	`AGGGCA/GGCAGG`	1	--	ng3¹		2		MN EA	356
	rs589759^1,2	A,C,F	32868866(+)	`ATTCTC/TTAAGA`	1	--	ut3¹		2		EA	180
	rs525720^1,2	C,F,H	32876426(-)	`AACTGG/AAGGAA`	1	--	ng3¹ trp³		14		EA EU WA	1438
	rs533115^1,2	C,F,H	32877217(+)	`AATGGG/AGGTCT`	1	--	ng3¹		4		EU EA WA	414
	rs746216^1,2	C,F,H	32875584(+)	`AAAGGG/AGCACC`	1	--	ng3¹		6		EA EU WA	598
--	rs8037241^1,2	A,C	32868460(+)	`TGATAC/GAATGG`	1	--	ut3¹		0	--	--	--	--
	rs3759834^1,2	F,H	32875997(-)	`TTGTCT/CCCACC`	1	--	ng3¹		5		EA EU WA	1896

About this table

HapMap Linkage Disequilibrium images for ACTC1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 102540

UniProtKB/Swiss-Prot: ACTC_HUMAN, P68032

Defects in ACTC1 are the cause of cardiomyopathy dilated type 1R (CMD1R) [MIM:102540].

Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic

function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature

death

Defects in ACTC1 are the cause of cardiomyopathy familial hypertrophic type 11 (CMH11)

[MIM:612098]. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by

ventricular hypertrophy, which is usually asymmetric and often involves the interventricular

septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be

readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from

benign to malignant forms with high risk of cardiac failure and sudden cardiac death

10/93 Novoseek disease relationships for ACTC1 gene (see all 93 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
myoepithelioma	85.47	7	9431536 (2), 15619979 (1), 15717758 (1), 7542546 (1) (see all 6)
leiomyosarcoma	84.46	19	14576480 (2), 9298873 (2), 8872438 (1), 8140724 (1) (see all 17)
smooth muscle tumor	83.69	4	12090595 (1), 12296754 (1), 16400320 (1), 8190481 (1)
stromal tumors	83.36	1	7688213 (1)
gastrointestinal stromal tumor	82.73	6	18996821 (1), 18976023 (1), 15232741 (1), 12483251 (1)
leiomyoma	79.02	19	15307213 (1), 18208801 (1), 14576480 (1), 16293183 (1) (see all 18)
angiomyolipoma	77.64	6	11485907 (1), 11033464 (1), 11914628 (1), 18620999 (1) (see all 6)
tumors	77.16	288	9237180 (2), 15692950 (2), 15295674 (2), 7773942 (2) (see all 99)
rhabdoid tumor	74.63	1	11468564 (1)
histiocytoma fibrous	71.97	2	9236835 (1), 16740036 (1)

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GeneTests: ACTC1

Familial Hypertrophic Cardiomyopathy

Human Gene Mutation Database: ACTC1
Human Genome Epidemiology Navigator: ACTC1 (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/817 PubMed articles for ACTC1 gene (see all 817 ):

Alpha-cardiac actin mutations produce atrial septal defects. (PubMed id 17947298)^{1, 3, 4} Matsson H....Dahl N. (2008)
Alpha-cardiac actin is a novel disease gene in familial hypertrophic cardiomyopathy. (PubMed id 10330430)^{1, 3, 4} Mogensen J.... Boerglum A.D. (1999)
Inherited and de novo mutations in the cardiac actin gene cause hypertrophic cardiomyopathy. (PubMed id 10966831)^{1, 3, 4} Olson T.M....Fananapazir L. (2000)
Shared genetic causes of cardiac hypertrophy in children and adults. (PubMed id 18403758)^{1, 3, 4} Morita H....Seidman C.E. (2008)
Actin mutations in dilated cardiomyopathy, a heritable form of heart failure. (PubMed id 9563954)^{1, 3, 4} Olson T.M.... Keating M.T. (1998)
Regional localization of the gene for cardiac muscle actin (ACTC) on chromosome 15q. (PubMed id 1639426)^{1, 2, 3} Kramer P.L....Litt M. (1992)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Molecular structure and evolutionary origin of human cardiac muscle actin gene. (PubMed id 6310553)^{3, 4} Hamada H.... Kakunaga T. (1982)
Overexpression of cardiac actin with baculovirus is promoter dependent. (PubMed id 17765196)^{1, 3} Yates S.P....Dawson J.F. (2007)
Dual roles of Gln137 of actin revealed by recombinant human cardiac muscle alpha-actin mutants. (PubMed id 18515362)^{1, 3} Iwasa M....Oda T. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 70	HGNC: 143	AceView: ACTC	Ensembl:ENSG00000159251	euGenes: HUgn70
ECgene: ACTC1	H-InvDB: ACTC1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
Familial hypertrophic cardiomyopathy mutation database	http://www.angis.org.au/Databases/Heart/heartbreak.html
GeneReviews	http://www.genetests.org/query?gene=ACTC1

Licensable Technologies for ACTC1
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ACTC1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ACTC1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ACTC1		Antibodies for ACTC1
	Explore super-pooled esiRNAs		Proteins for ACTC1
	Lentivirus-delivered shRNAs for ACTC1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (ACTC)
	Search for Antibodies
	Search for Chimera RNAi
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (Pan Muscle Alpha Actin , Actin, muscle Actin, alpha sarcomeric Actin)
	Antibodies (Pan Muscle Alpha Actin , Actin, muscle Actin, alpha sarcomeric Actin)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for ACTC1

	Drugs for ACTC1
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for ACTC1

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ACTC1 Gene

protein-coding GIFtS: 56

Aliases &
Descriptions
for ACTC1

Summaries
for ACTC1

Genomic Location
for ACTC1

Proteins
for ACTC1

Protein Domains/
Families
for ACTC1

Gene Function
for ACTC1

Pathways & Interactions
for ACTC1

Drugs & Compounds
for ACTC1

Transcripts
for ACTC1

Expression
for ACTC1

Orthologs
for ACTC1

Paralogs
for ACTC1

SNPs/Variants
for ACTC1

Disorders & Mutations
for ACTC1

Medical News
for ACTC1

Publications
for ACTC1

Search for ACTC1

Genome Databases showing ACTC1

Other Databases showing ACTC1

Specialized Databases showing ACTC1

Licensable Technologies
for ACTC1

Services
for ACTC1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ACTC1 Gene

protein-coding GIFtS: 56

Aliases & Descriptionsfor ACTC1

Summariesfor ACTC1

Genomic Locationfor ACTC1

Proteinsfor ACTC1

Protein Domains/Familiesfor ACTC1

Gene Functionfor ACTC1

Pathways & Interactionsfor ACTC1

Drugs & Compoundsfor ACTC1

Transcriptsfor ACTC1

Expression for ACTC1

Orthologsfor ACTC1

Paralogsfor ACTC1

SNPs/Variantsfor ACTC1

Disorders & Mutationsfor ACTC1

Medical Newsfor ACTC1

Publicationsfor ACTC1

Search for ACTC1

Genome Databases showing ACTC1

Other Databases showing ACTC1

Specialized Databases showing ACTC1

Licensable Technologiesfor ACTC1

Servicesfor ACTC1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ACTC1

Summaries
for ACTC1

Genomic Location
for ACTC1

Proteins
for ACTC1

Protein Domains/
Families
for ACTC1

Gene Function
for ACTC1

Pathways & Interactions
for ACTC1

Drugs & Compounds
for ACTC1

Transcripts
for ACTC1

Expression
for ACTC1

Orthologs
for ACTC1

Paralogs
for ACTC1

SNPs/Variants
for ACTC1

Disorders & Mutations
for ACTC1

Medical News
for ACTC1

Publications
for ACTC1

Licensable Technologies
for ACTC1

Services
for ACTC1