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Aliases for ACTBL2 Gene

Aliases for ACTBL2 Gene

  • Actin, Beta-Like 2 2 3 5
  • Kappa-Actin 3 4
  • Actin-Like Protein 3
  • ACT 3

External Ids for ACTBL2 Gene

Previous GeneCards Identifiers for ACTBL2 Gene

  • GC00U921642
  • GC05M056813
  • GC05M053748

Summaries for ACTBL2 Gene

GeneCards Summary for ACTBL2 Gene

ACTBL2 (Actin, Beta-Like 2) is a Protein Coding gene. An important paralog of this gene is ACTRT1.

UniProtKB/Swiss-Prot for ACTBL2 Gene

  • Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACTBL2 Gene

Genomics for ACTBL2 Gene

Regulatory Elements for ACTBL2 Gene

Enhancers for ACTBL2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ACTBL2 on UCSC Golden Path with GeneCards custom track

Genomic Location for ACTBL2 Gene

57,480,016 bp from pter
57,482,809 bp from pter
2,794 bases
Minus strand

Genomic View for ACTBL2 Gene

Genes around ACTBL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACTBL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACTBL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACTBL2 Gene

Proteins for ACTBL2 Gene

  • Protein details for ACTBL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Beta-actin-like protein 2
    Protein Accession:
    Secondary Accessions:
    • B2RPJ1
    • Q562R2
    • Q562S9
    • Q562X8

    Protein attributes for ACTBL2 Gene

    376 amino acids
    Molecular mass:
    42003 Da
    Quaternary structure:
    • Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others (By similarity). Interacts with PFN1 and PFDN1.
    • In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.

neXtProt entry for ACTBL2 Gene

Proteomics data for ACTBL2 Gene at MOPED

Post-translational modifications for ACTBL2 Gene

  • Monomethylation at Lys-85 (K84me1) regulates actin-myosin interaction and actomyosin-dependent processes. Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration (By similarity).
  • Oxidation of Met-45 and Met-48 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promote actin repolymerization (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ACTBL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ACTBL2 Gene

Domains & Families for ACTBL2 Gene

Protein Domains for ACTBL2 Gene

Suggested Antigen Peptide Sequences for ACTBL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the actin family.
  • Belongs to the actin family.
genes like me logo Genes that share domains with ACTBL2: view

No data available for Gene Families for ACTBL2 Gene

Function for ACTBL2 Gene

Molecular function for ACTBL2 Gene

UniProtKB/Swiss-Prot Function:
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.

Gene Ontology (GO) - Molecular Function for ACTBL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with ACTBL2: view

Phenotypes for ACTBL2 Gene

genes like me logo Genes that share phenotypes with ACTBL2: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ACTBL2 Gene

Localization for ACTBL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACTBL2 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

Jensen Localization Image for ACTBL2 Gene COMPARTMENTS Subcellular localization image for ACTBL2 gene
Compartment Confidence
extracellular 5
cytoskeleton 4
cytosol 3

Gene Ontology (GO) - Cellular Components for ACTBL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 22664934
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with ACTBL2: view

Pathways & Interactions for ACTBL2 Gene

SuperPathways for ACTBL2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ACTBL2 Gene


No data available for Pathways by source and SIGNOR curated interactions for ACTBL2 Gene

Drugs & Compounds for ACTBL2 Gene

No Compound Related Data Available

Transcripts for ACTBL2 Gene

mRNA/cDNA for ACTBL2 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ACTBL2 Gene

Actin, beta-like 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ACTBL2 Gene

No ASD Table

Relevant External Links for ACTBL2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ACTBL2 Gene

mRNA expression in normal human tissues for ACTBL2 Gene

mRNA differential expression in normal tissues according to GTEx for ACTBL2 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x26.2), Skin - Sun Exposed (Lower leg) (x4.4), Minor Salivary Gland (x4.3), and Testis (x4.1).

Protein differential expression in normal tissues from HIPED for ACTBL2 Gene

This gene is overexpressed in Bone marrow stromal cell (16.9), Amniocyte (16.7), and Bone marrow mesenchymal stem cell (15.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ACTBL2 Gene

SOURCE GeneReport for Unigene cluster for ACTBL2 Gene Hs.482167

genes like me logo Genes that share expression patterns with ACTBL2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ACTBL2 Gene

Orthologs for ACTBL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ACTBL2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ACTBL2 35
  • 90.25 (n)
  • 96.54 (a)
  • 45 (a)
(Canis familiaris)
Mammalia ACTBL2 35
  • 90.87 (n)
  • 96.81 (a)
  • 47 (a)
(Mus musculus)
Mammalia Actbl2 35
  • 89.45 (n)
  • 97.07 (a)
Actbl2 16
Actbl2 36
  • 97 (a)
(Pan troglodytes)
Mammalia ACTBL2 35
  • 99.29 (n)
  • 99.73 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Actbl2 35
  • 89.45 (n)
  • 96.81 (a)
(Monodelphis domestica)
Mammalia ACTBL2 36
  • 94 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 52 (a)
(Anolis carolinensis)
Reptilia ACTBL2 36
  • 65 (a)
fruit fly
(Drosophila melanogaster)
Insecta Arp53D 36
  • 61 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 52 (a)
Species with no ortholog for ACTBL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ACTBL2 Gene

Gene Tree for ACTBL2 (if available)
Gene Tree for ACTBL2 (if available)

Paralogs for ACTBL2 Gene Pseudogenes for ACTBL2 Gene

genes like me logo Genes that share paralogs with ACTBL2: view

Variants for ACTBL2 Gene

Sequence variations from dbSNP and Humsavar for ACTBL2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1979725 -- 57,479,751(-) ACAAC(A/G)TCAAC downstream-variant-500B
rs13159014 -- 57,480,426(+) ACTGG(A/G)GTAAC utr-variant-3-prime
rs73757385 -- 57,479,605(+) CTGTC(C/T)CATTT downstream-variant-500B
rs11950494 -- 57,480,984(+) TGACT(G/T)TTGGG utr-variant-3-prime
rs117381729 -- 57,480,588(+) ATACT(A/G)GTAGT utr-variant-3-prime

Variation tolerance for ACTBL2 Gene

Residual Variation Intolerance Score: 89.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.60; 56.33% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for ACTBL2 Gene

Disorders for ACTBL2 Gene

Relevant External Links for ACTBL2

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ACTBL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ACTBL2 Gene

Publications for ACTBL2 Gene

  1. A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants. (PMID: 22219177) Tao S. … Sun J. (Carcinogenesis 2012) 3 48 67
  2. Proteomic discovery of MNT as a novel interacting partner of E3 ubiquitin ligase E6AP and a key mediator of myeloid differentiation. (PMID: 26506232) Kapoor I. … Trivedi A.K. (Oncotarget 2016) 3
  3. Ski regulates Hippo and TAZ signaling to suppress breast cancer progression. (PMID: 25670202) Rashidian J. … Luo K. (Sci Signal 2015) 3
  4. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for ACTBL2 Gene

Sources for ACTBL2 Gene