ACTBL2 Gene
protein-coding GIFtS: 39
GCID: GC05M056813
|
|
actin, beta-like 2
| |
Aliases
for ACTBL2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Actin, Beta-Like 21 2 | | Beta-Actin-Like Protein 22 | | DKFZp686D09721 | | Kappa-Actin1 | | ACT2 | | Kappa-Actin1 | | Actin-Like Protein2 | | |
Export aliases for ACTBL2 gene to outside databasesPrevious GC identifers: GC00U921642 GC05M053748 |
Summaries
for ACTBL2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ACTBL_HUMAN, Q562R1Function: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitouslyexpressed in all eukaryotic cells (By similarity)
|
Genomic Views
for ACTBL2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_006713.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ACTBL2 gene promoter:
FOXF2 AML1a Pax-5 LUN-1 Tal-1beta AREB6 POU2F1 POU2F1a ITF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for ACTBL2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ACTBL2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q11.2 Ensembl cytogenetic band: 5q11.2 HGNC cytogenetic band: 5q11.2ACTBL2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05M056813: view genomic region
(about GC identifiers)
Start:
|
56,775,843 bp from pter |
End:
|
56,778,636 bp from pter |
Size:
|
2,794 bases |
Orientation:
|
minus strand |
|
Proteins
for ACTBL2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ACTBL_HUMAN, Q562R1 (See
protein sequence)Recommended Name: Beta-actin-like protein 2 Size: 376 amino acids; 42003 Da
Subunit: Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of atwo-stranded helix. Each actin can bind to 4 others (By similarity). Interacts with PFN1 and PFDN1
Subcellular location: Cytoplasm, cytoskeleton (By similarity)
Miscellaneous: In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alphaactins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actinscoexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility
Secondary accessions: B2RPJ1 Q562R2 Q562S9 Q562X8Explore the universe of human proteins at neXtProt for ACTBL2: NX_Q562R1
Post-translational modifications:
Oxidation of Met-45 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filamentdepolymerization. Methionine sulfoxide is produced stereospecifically, but it is not known whether the (S)-S-oxide orthe (R)-S-oxide is produced (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q562R1
ACTBL2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001017992.1
ENSEMBL proteins: ENSP00000416706
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
ACTBL2 for ontologies About GeneDecksing
ACTBL2 Antibody Products:
Assay Products for ACTBL2: |
Protein
Domains /
Families
for ACTBL2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ACTBL2 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q562R1ProtoNet protein and cluster: Q562R1 UniProtKB/Swiss-Prot: ACTBL_HUMAN, Q562R1Similarity: Belongs to the actin family |
Function
for ACTBL2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ACTBL_HUMAN, Q562R1Function: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitouslyexpressed in all eukaryotic cells (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ACTBL2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ACTBL2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ACTBL2 (NM_001017992) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ACTBL2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACTBL2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACTBL2 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005524 | ATP binding |
IEA | -- |
ACTBL2 for ontologies About GeneDecksing
|
Pathways & Interactions
for ACTBL2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ACTBL2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 12)
5/74 Interacting proteins for ACTBL2 (Q562R13 ENSP000004167064) via UniProtKB, MINT, STRING, and/or I2D (see all 74)About this table
|
Drugs & Compounds
for ACTBL2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ACTBL2
Search CenterWatch for drugs/clinical trials and news about ACTBL2 / ACTBL
|
Transcripts
for ACTBL2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ACTBL2 gene: NM_001017992.3 Unigene Cluster for ACTBL2: Actin, beta-like 2 Hs.482167 Unigene Representative Sequence: BX6485041 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000423391(uc003jrm.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ACTBL2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ACTBL2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ACTBL2 (NM_001017992) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ACTBL2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACTBL2 |
Additional cDNA sequence: BC137470.1 BC137473.1 BX648504.1 1 DOTS entry: DT.101966068 2 AceView cDNA sequences: BX648504 BP872797
GeneLoc Exon Structure
|
Expression
for ACTBL2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ACTBL2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAAATCAAGA
About this image
See ACTBL2 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.482167
SABiosciences Custom PCR Arrays for ACTBL2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ACTBL2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ACTBL2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ACTBL2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ACTBL2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACTBL2 |
Orthologs
for ACTBL2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for ACTBL2 gene from 8/25 species (see all 25) About this table
ENSEMBL Gene Tree for ACTBL2 (if available)
TreeFam Gene Tree for ACTBL2 (if available) |
Paralogs
for ACTBL2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ACTBL2 gene
- ACTG22 ACTA22 ACTB2 ACTRT22 ACTR1A2 ACTC12 ACTL92 ACTRT12
- ACTG12 ACTL7A2 ACTL7B2 ACTR1B2 ACTA12 ACTRT32
18/31 SIMAP similar genes for ACTBL2 using alignment to 1 protein entry: ACTBL_HUMAN(see all similar genes):PS1TP5BP1 ACTB ACTA2 ACTC1 ACTG1 ACT
POTEE POTEF POTEI POTEJ POTEKP ACTG2
ACTR1B ACTR1A ACTRT3 ACTA1 ACTRT1 ACTR2
ACTBL2 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for ACTBL2
PGOHUM00000235509
|
Genomic Variants
for ACTBL2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ACTBL2 (56775843 - 56778636 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ACTBL2: -- | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for ACTBL2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ACTBL2 for disorders About GeneDecksing
OMIM gene information: 614835
OMIM disorders: --
4  diseases for ACTBL2: About MalaCardshepatocellular carcinoma pharyngitis carcinoma malaria
Export disorders for ACTBL2 gene to outside databases
|
Publications
for ACTBL2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ACTBL2 gene, integrated from 9 sources (see all 23):
(articles sorted by number of sources associating them with ACTBL2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of a novel actin isoform in hepatocellular carcinoma. (PubMed id 16824795)1, 2 Chang K.-W.... Yeh C.-T. (2006)
- Downregulation of b-actin gene and human antigen R in human keratoconus. (PubMed id 22562506)1 Joseph R....Pfister R.R. (2012)
- Sp1 phosphorylation by cyclin-dependent kinase 1/cycli n B1 represses its DNA-binding activity during mitosis in cancer cells. (PubMed id 22266860)1 Chuang J.Y....Hung J.J. (2012)
- A genome-wide search for loci interacting with known p rostate cancer risk-associated genetic variants. (PubMed id 22219177)1 Tao S....Sun J. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Integrative analysis of the ubiquitin proteome isolat ed using Tandem Ubiquitin Binding Entities (TUBEs). (PubMed id 22178446)1 Lopitz-Otsoa F....Rodriguez M.S. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyc losome substrate. (PubMed id 21628590)1 Emanuele M.J....Elledge S.J. (2011)
|
External Searches for ACTBL2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ACTBL2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ACTBL2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ACTBL2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ACTBL2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ACTBL2 gene:
Search GeneIP for patents involving ACTBL2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ACTBL2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ACTBL2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ACTBL2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ACTBL2 | | | OriGene Protein Over-expression Lysate for ACTBL2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ACTBL2 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ACTBL2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ACTBL2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ACTBL2 | | OriGene Custom Protein Services for ACTBL2 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ACTBL2 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ACTBL2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ACTBL2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ACTBL2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ACTBL2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ACTBL2 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for ACTBL2 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | ACTBL2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACTBL2 |
|  |  |  | | | | Search ThermoFisher Antibodies for ACTBL2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACTBL2 |
|
|
|
|
