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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ACTBL2 Gene

protein-coding   GIFtS: 40
GCID: GC05M056813

Actin, Beta-Like 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Actin, Beta-Like 21 2
ACT2
Actin-Like Protein2
Beta-Actin-Like Protein 22
kappa-actin2
Kappa-actin3

External Ids:    HGNC: 177801   Entrez Gene: 3456512   Ensembl: ENSG000001690677   OMIM: 6148355   UniProtKB: Q562R13   

Export aliases for ACTBL2 gene to outside databases

Previous GC identifers: GC00U921642 GC05M053748


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ACTBL2 Gene: 
ACTBL2 (actin, beta-like 2) is a protein-coding gene. Diseases associated with ACTBL2 include keratoconus, and hepatocellular carcinoma. GO annotations related to this gene include ATP binding. An important paralog of this gene is ACTG2.

UniProtKB/Swiss-Prot: ACTBL_HUMAN, Q562R1
Function: Actins are highly conserved proteins that are involved in various types of cell motility and are
ubiquitously expressed in all eukaryotic cells (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NT_006713.15  NC_018916.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ACTBL2 gene promoter:
         FOXF2   AML1a   Pax-5   LUN-1   Tal-1beta   AREB6   POU2F1   POU2F1a   ITF-2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for ACTBL2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ACTBL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q11.2   Ensembl cytogenetic band:  5q11.2   HGNC cytogenetic band: 5q11.2

ACTBL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ACTBL2 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M056813:  view genomic region     (about GC identifiers)

Start:
56,775,843 bp from pter      End:
56,778,636 bp from pter
Size:
2,794 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ACTBL_HUMAN, Q562R1 (See protein sequence)
Recommended Name: Beta-actin-like protein 2  
Size: 376 amino acids; 42003 Da
Subunit: Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a
two-stranded helix. Each actin can bind to 4 others (By similarity). Interacts with PFN1 and PFDN1
Subcellular location: Cytoplasm, cytoskeleton (By similarity)
Miscellaneous: In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The
alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and
gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell
motility
Secondary accessions: B2RPJ1 Q562R2 Q562S9 Q562X8

Explore the universe of human proteins at neXtProt for ACTBL2: NX_Q562R1

Explore proteomics data for ACTBL2 at MOPED 

Post-translational modifications:

  • UniProtKB: Oxidation of Met-45 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament
    depolymerization. Methionine sulfoxide is produced stereospecifically, but it is not known whether the
    (S)-S-oxide or the (R)-S-oxide is produced (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q562R1

  • ACTBL2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ACTBL2 Protein Expression
    REFSEQ proteins: NP_001017992.1  
    ENSEMBL proteins: 
     ENSP00000416706  

    Human Recombinant Protein Products for ACTBL2: 
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    OriGene Protein Over-expression Lysate for ACTBL2
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005856cytoskeleton IEA--

    ACTBL2 for ontologies           About GeneDecksing



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    Abcam antibodies for ACTBL2
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    LSBio Antibodies in human, mouse, rat for ACTBL2 

    Assay Products for ACTBL2: 
    Browse Kits and Assays available from EMD Millipore
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    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR004001 Actin_CS
     IPR004000 Actin-related
     IPR020902 Actin/actin-like_CS

    Graphical View of Domain Structure for InterPro Entry Q562R1

    ProtoNet protein and cluster: Q562R1

    UniProtKB/Swiss-Prot: ACTBL_HUMAN, Q562R1
    Similarity: Belongs to the actin family


    ACTBL2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ACTBL_HUMAN, Q562R1
    Function: Actins are highly conserved proteins that are involved in various types of cell motility and are
    ubiquitously expressed in all eukaryotic cells (By similarity)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005524ATP binding IEA--
         
    ACTBL2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ACTBL2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ACTBL2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ACTBL2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ACTBL2 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ACTBL2
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate ACTBL2:
    hsa-miR-3163 hsa-miR-520d-5p hsa-miR-101* hsa-miR-192 hsa-miR-1270 hsa-miR-620 hsa-miR-524-5p hsa-miR-215
    SwitchGear 3'UTR luciferase reporter plasmidACTBL2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for ACTBL2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ACTBL2 (NM_001017992)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ACTBL2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACTBL2
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                         Customized lentivirus expression plasmids for stable overexpression of ACTBL2 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACTBL2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ACTBL2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    5/74 Interacting proteins for ACTBL2 (Q562R13 ENSP000004167064) via UniProtKB, MINT, STRING, and/or I2D (see all 74)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP2CBP627143, ENSP000002211384I2D: score=1 STRING: ENSP00000221138
    PXKQ7Z7A43, ENSP000003484724I2D: score=1 STRING: ENSP00000348472
    MAP1LC3BQ9GZQ83, ENSP000002686074I2D: score=2 STRING: ENSP00000268607
    GABARAPO951663I2D: score=2 
    GABARAPL1Q9H0R83I2D: score=2 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ACTBL2 (ACTBL)

    Search CenterWatch for drugs/clinical trials and news about ACTBL2 / ACTBL

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ACTBL2 gene: 
    NM_001017992.3  

    Unigene Cluster for ACTBL2:

    Actin, beta-like 2
    Hs.482167
    Unigene Representative Sequence: BX648504
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000423391(uc003jrm.3)
    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ACTBL2
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate ACTBL2:
    hsa-miR-3163 hsa-miR-520d-5p hsa-miR-101* hsa-miR-192 hsa-miR-1270 hsa-miR-620 hsa-miR-524-5p hsa-miR-215
    SwitchGear 3'UTR luciferase reporter plasmidACTBL2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ACTBL2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ACTBL2
    Clone
    Products:
         
    OriGene clones in human, mouse for ACTBL2 (see all 6)
    OriGene ORF clones in mouse, rat for ACTBL2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ACTBL2 (NM_001017992)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ACTBL2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACTBL2
    Sirion Biotech Customized lentivirus for stable overexpression of ACTBL2 
                         Customized lentivirus expression plasmids for stable overexpression of ACTBL2 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ACTBL2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ACTBL2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ACTBL2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ACTBL2

    Additional mRNA sequence: 

    BC137470.1 BC137473.1 BX648504.1 

    1 DOTS entry:

    DT.101966068 

    2 AceView cDNA sequences:

    BX648504 BP872797 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ACTBL2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAATCAAGA
    ACTBL2 Expression
    About this image


    See ACTBL2 Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.482167
        SABiosciences Custom PCR Arrays for ACTBL2
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for ACTBL2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ACTBL2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ACTBL2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ACTBL2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACTBL2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ACTBL2 gene from 9/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Actbl21 , 5 actin, beta-like 21, 5 89.45(n)1
    97.07(a)1
      13 (63.10 cM)5
    2388801  NM_175497.31  NP_780706.11 
     1112550135 
    chicken
    (Gallus gallus)
    Aves ACTG11 actin, gamma 1 82.54(n)
    92.02(a)
      415296  NM_001007824.1  NP_001007825.1 
    lizard
    (Anolis carolinensis)
    Reptilia ACTB6
    Uncharacterized protein
    87(a)
    1 ↔ 1
    GL344051.1(74996-83159)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:867091 zgc:86709 78.34(n)
    88.5(a)
      570210  NM_001002066.1  NP_001002066.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Act42A1 Actin 42A 76.33(n)
    90.16(a)
      35526  NM_078901.2  NP_523625.1 
    worm
    (Caenorhabditis elegans)
    Secernentea act-26
    act-16
    (see all 4)
    Actin-1/3
    (see all 4)
    90(a)
    90(a)
    (see all 4)
    possible ortholog
    possible ortholog
    (see all 4)
    V(11076737-11078168)
    V(11079167-11082497)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ACT16
    Actin, structural protein involved in cell polariz...
    83(a)
    1 → many
    VI(53260-54696)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ACT111 actin-11 72.61(n)
    84.57(a)
      820385  NM_112046.3  NP_187818.1 
    rice
    (Oryza sativa)
    Liliopsida Os05g01066001 hypothetical protein 72.52(n)
    84.04(a)
      4337566  NM_001060954.1  NP_001054419.1 


    ENSEMBL Gene Tree for ACTBL2 (if available)
    TreeFam Gene Tree for ACTBL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ACTBL2 gene
    ACTG22  ACTA22  ACTRT22  ACTR1A2  ACTB2  ACTC12  ACTRT12  ACTG12  
    ACTL7A2  ACTL7B2  ACTR1B2  ACTA12  ACTRT32  
    18/32 SIMAP similar genes for ACTBL2 using alignment to 1 protein entry:     ACTBL_HUMAN(see all similar genes):
    PS1TP5BP1    ACTB    ACTA2    ACTC1    ACTG1    ACT
    POTEE    POTEF    POTEI    POTEJ    POTEKP    POTEM
    ACTG2    ACTR1B    ACTR1A    ACTRT3    ACTA1    ACTRT1

    ACTBL2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ACTBL2
    PGOHUM00000235509


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/178 SNPs in ACTBL2 are shown (see all 178)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1473485911,2
    --56775348(+) AATGCA/GTAGTT 1 -- ds50010--------
    rs1394193881,2
    --56775393(+) TGGGGC/TTCTAT 1 -- ds50010--------
    rs737573851,2
    C,F--56775432(+) CTGTCC/TCATTT 1 -- ds50014Minor allele frequency- T:0.10WA CSA NA 241
    rs1916994941,2
    --56775501(+) GAATGC/TTTGTG 1 -- ds50010--------
    rs1854702321,2
    --56775528(+) CAAATA/GGAATG 1 -- ds50010--------
    rs1435275481,2
    --56775555(+) TCCAAA/TATATT 1 -- ds50010--------
    rs19797251,2
    C,F,O,A,H--56775578(-) ACAACA/GTCAAC 1 -- ds500131Minor allele frequency- G:0.30MN NS EA NA WA CSA 3044
    rs1471555341,2
    --56775653(+) TGAGAA/CATCTA 1 -- ds50010--------
    rs1399241281,2
    C--56775731(+) ATGAGG/TTGCAA 1 -- ds50010--------
    rs1899464631,2
    --56775830(+) AATAAC/GAGGAA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for ACTBL2 (56775843 - 56778636 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for ACTBL2: --
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing ACTBL2
    DNA2.0 Custom Variant and Variant Library Synthesis for ACTBL2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 614835    OMIM disorders: --

    2 diseases for ACTBL2:    About MalaCards
    keratoconus    hepatocellular carcinoma


    ACTBL2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ACTBL2

    Export disorders for ACTBL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ACTBL2 gene, integrated from 9 sources (see all 36):
    (articles sorted by number of sources associating them with ACTBL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A genome-wide search for loci interacting with known p rostate cancer risk-associated genetic variants. (PubMed id 22219177)1, 4 Tao S....Sun J. (2012)
    2. Identification of a novel actin isoform in hepatocellular carcinoma. (PubMed id 16824795)1, 2 Chang K.-W.... Yeh C.-T. (2006)
    3. Interlaboratory reproducibility of large-scale human p rotein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (2013)
    4. A Proteomics Strategy for the Identification of FAT10- Modified Sites by Mass Spectrometry. (PubMed id 23862649)1 Leng L....Wang J. (2013)
    5. Sp1 phosphorylation by cyclin-dependent kinase 1/cycli n B1 represses its DNA-binding activity during mitosis in cancer cells. (PubMed id 22266860)1 Chuang J.Y....Hung J.J. (2012)
    6. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    7. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    8. Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)
    9. Downregulation of b-actin gene and human antigen R in human keratoconus. (PubMed id 22562506)1 Joseph R....Pfister R.R. (2012)
    10. Viral immune modulators perturb the human molecular ne twork by common and unique strategies. (PubMed id 22810585)1 Pichlmair A....Superti-Furga G. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 345651 HGNC: 17780 AceView: LOC345651 Ensembl:ENSG00000169067 euGenes: HUgn345651
    ECgene: ACTBL2 H-InvDB: ACTBL2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ACTBL2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ACTBL2 gene:
    Search GeneIP for patents involving ACTBL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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