Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



ACTBL2 Gene

protein-coding   GIFtS: 41
GCID: GC05M056813

Actin, Beta-Like 2

  Search for ACTBL2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Actin, Beta-Like 21 2
ACT2
Actin-Like Protein2
Beta-Actin-Like Protein 22
kappa-actin2
Kappa-actin3

External Ids:    HGNC: 177801   Entrez Gene: 3456512   Ensembl: ENSG000001690677   OMIM: 6148355   UniProtKB: Q562R13   

Export aliases for ACTBL2 gene to outside databases

Previous GC identifers: GC00U921642 GC05M053748


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for ACTBL2 Gene:
ACTBL2 (actin, beta-like 2) is a protein-coding gene. An important paralog of this gene is ACTG2.

UniProtKB/Swiss-Prot: ACTBL_HUMAN, Q562R1
Function: Actins are highly conserved proteins that are involved in various types of cell motility and are
ubiquitously expressed in all eukaryotic cells (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000005.10  NC_018916.2  NT_034772.7  
Regulatory elements:
   Regulatory transcription factor binding sites in the ACTBL2 gene promoter:
         FOXF2   AML1a   Pax-5   LUN-1   Tal-1beta   AREB6   POU2F1   POU2F1a   ITF-2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for ACTBL2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ACTBL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q11.2   Ensembl cytogenetic band:  5q11.2   HGNC cytogenetic band: 5q11.2

ACTBL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ACTBL2 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M056813:  view genomic region     (about GC identifiers)

Start:
56,775,843 bp from pter      End:
56,778,636 bp from pter
Size:
2,794 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: ACTBL_HUMAN, Q562R1 (See protein sequence)
Recommended Name: Beta-actin-like protein 2  
Size: 376 amino acids; 42003 Da
Subunit: Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a
two-stranded helix. Each actin can bind to 4 others (By similarity). Interacts with PFN1 and PFDN1
Miscellaneous: In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The
alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and
gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell
motility
Secondary accessions: B2RPJ1 Q562R2 Q562S9 Q562X8

Explore the universe of human proteins at neXtProt for ACTBL2: NX_Q562R1

Explore proteomics data for ACTBL2 at MOPED

Post-translational modifications: 

  • Oxidation of Met-45 and Met-48 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin
    filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by
    MSRB1 and MSRB2, which promote actin repolymerization (By similarity)1
  • Monomethylation at Lys-85 (K84me1) regulates actin-myosin interaction and actomyosin-dependent processes.
    Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow
    ingression during cytokinesis and cell migration (By similarity)1
  • Ubiquitination2 at Lys192, Lys329
  • Modification sites at PhosphoSitePlus

  • See ACTBL2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001017992.1  
    ENSEMBL proteins: 
     ENSP00000416706  

    ACTBL2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for ACTBL2
    OriGene Custom MassSpec
    OriGene Custom Protein Services for ACTBL2
    GenScript Custom Purified and Recombinant Proteins Services for ACTBL2
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for ACTBL2 

    ACTBL2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for ACTBL2
    OriGene Custom Antibody Services for ACTBL2
    Abcam antibodies for ACTBL2
    Browse Antibodies at Cloud-Clone Corp.
    Search ThermoFisher Antibodies for ACTBL2
    LSBio Antibodies in human, mouse, rat for ACTBL2

    ACTBL2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ACTBL2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ACTBL2
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for ACTBL2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    3 InterPro protein domains:
     IPR020902 Actin/actin-like_CS
     IPR004001 Actin_CS
     IPR004000 Actin-related

    Graphical View of Domain Structure for InterPro Entry Q562R1

    ProtoNet protein and cluster: Q562R1

    UniProtKB/Swiss-Prot: ACTBL_HUMAN, Q562R1
    Similarity: Belongs to the actin family


    Find genes that share domains with ACTBL2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ACTBL_HUMAN, Q562R1
    Function: Actins are highly conserved proteins that are involved in various types of cell motility and are
    ubiquitously expressed in all eukaryotic cells (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005524ATP binding IEA--
         
    Find genes that share ontologies with ACTBL2           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ACTBL2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ACTBL2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ACTBL2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ACTBL2

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat ACTBL2 using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate ACTBL2:
    hsa-miR-3163 hsa-miR-520d-5p hsa-miR-101* hsa-miR-192 hsa-miR-1270 hsa-miR-620 hsa-miR-524-5p hsa-miR-215
    SwitchGear 3'UTR luciferase reporter plasmidACTBL2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ACTBL2
    Predesigned siRNA for gene silencing in human, mouse, rat ACTBL2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ACTBL2

    Clone
    Products:
         
    OriGene clones in human, mouse for ACTBL2 (see all 6)
    OriGene ORF clones in mouse, rat for ACTBL2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ACTBL2 (NM_001017992)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ACTBL2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACTBL2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ACTBL2
    Browse ESI BIO Cell Lines and PureStem Progenitors for ACTBL2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACTBL2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    ACTBL_HUMAN, Q562R1: Cytoplasm, cytoskeleton (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    cytoskeleton2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA--
    GO:0005737cytoplasm IEA--
    GO:0005856cytoskeleton IEA--
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with ACTBL2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ACTBL2
    Interactions:

        Search GeneGlobe Interaction Network for ACTBL2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ACTBL2 (Q562R13 ENSP000004167064) via UniProtKB, MINT, STRING, and/or I2D (see all 88)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP2CBP627143, ENSP000002211384I2D: score=1 STRING: ENSP00000221138
    PXKQ7Z7A43, ENSP000003484724I2D: score=1 STRING: ENSP00000348472
    MAP1LC3BQ9GZQ83, ENSP000002686074I2D: score=2 STRING: ENSP00000268607
    LRRK2Q5S0073, ENSP000002989104I2D: score=1 STRING: ENSP00000298910
    GABARAPO951663I2D: score=2 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--

    Find genes that share ontologies with ACTBL2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ACTBL2 (ACTBL)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for ACTBL2 gene: 
    NM_001017992.3  

    Unigene Cluster for ACTBL2:

    Actin, beta-like 2
    Hs.482167
    Unigene Representative Sequence: BX648504
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000423391(uc003jrm.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ACTBL2 using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate ACTBL2:
    hsa-miR-3163 hsa-miR-520d-5p hsa-miR-101* hsa-miR-192 hsa-miR-1270 hsa-miR-620 hsa-miR-524-5p hsa-miR-215
    SwitchGear 3'UTR luciferase reporter plasmidACTBL2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ACTBL2
    Predesigned siRNA for gene silencing in human, mouse, rat ACTBL2
    Clone
    Products:
         
    OriGene clones in human, mouse for ACTBL2 (see all 6)
    OriGene ORF clones in mouse, rat for ACTBL2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ACTBL2 (NM_001017992)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ACTBL2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACTBL2
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ACTBL2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ACTBL2
      QuantiTect SYBR Green Assays in human, mouse, rat ACTBL2
      QuantiFast Probe-based Assays in human, mouse, rat ACTBL2

    Additional mRNA sequence: 

    BC137470.1 BC137473.1 BX648504.1 

    1 DOTS entry:

    DT.101966068 

    2 AceView cDNA sequences:

    BX648504 BP872797 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    ACTBL2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAATCAAGA
    ACTBL2 Expression
    About this image

    ACTBL2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ACTBL2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.482167
        Custom PCR Arrays for ACTBL2
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for ACTBL2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ACTBL2
    QuantiTect SYBR Green Assays in human, mouse, rat ACTBL2
    QuantiFast Probe-based Assays in human, mouse, rat ACTBL2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACTBL2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for ACTBL2 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Actbl21 , 5 actin, beta-like 21, 5 89.45(n)1
    97.07(a)1
      13 (63.10 cM)5
    2388801  NM_175497.31  NP_780706.11 
     1112550135 
    lizard
    (Anolis carolinensis)
    Reptilia ACTBL26
    actin, beta-like 2
    65(a)
    1 ↔ 1
    GL343721.1(262913-264040)
    fruit fly
    (Drosophila melanogaster)
    Insecta Arp53D6
    Actin-related protein 53D
    61(a)
    1 → many
    2R(12661811-12663179)


    ENSEMBL Gene Tree for ACTBL2 (if available)
    TreeFam Gene Tree for ACTBL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for ACTBL2 gene
    ACTG22  ACTA22  ACTRT22  ACTR1A2  ACTB2  ACTC12  ACTRT12  ACTG12  
    ACTR1B2  ACTA12  ACTRT32  
    Selected SIMAP similar genes for ACTBL2 using alignment to 1 protein entry:     ACTBL_HUMAN(see all similar genes):
    PS1TP5BP1    ACTB    ACTA2    ACTC1    ACTG1    ACT
    POTEE    POTEF    POTEI    POTEJ    POTEKP    POTEM
    ACTG2    ACTR1B    ACTR1A    ACTRT3    ACTA1    ACTRT1

    Find genes that share paralogs with ACTBL2           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for ACTBL2
    PGOHUM00000235509


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for ACTBL2 (see all 178)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1473485911,2
    --56775348(+) AATGCA/GTAGTT 1 -- ds50010--------
    rs1394193881,2
    --56775393(+) TGGGGC/TTCTAT 1 -- ds50010--------
    rs737573851,2
    C,F--56775432(+) CTGTCC/TCATTT 1 -- ds50014Minor allele frequency- T:0.10WA CSA NA 241
    rs1916994941,2
    --56775501(+) GAATGC/TTTGTG 1 -- ds50010--------
    rs1854702321,2
    --56775528(+) CAAATA/GGAATG 1 -- ds50010--------
    rs1435275481,2
    --56775555(+) TCCAAA/TATATT 1 -- ds50010--------
    rs19797251,2
    C,F,O,A,H--56775578(-) ACAACA/GTCAAC 1 -- ds500131Minor allele frequency- G:0.30MN NS EA NA WA CSA 3044
    rs1471555341,2
    --56775653(+) TGAGAA/CATCTA 1 -- ds50010--------
    rs1399241281,2
    C--56775731(+) ATGAGG/TTGCAA 1 -- ds50010--------
    rs1899464631,2
    --56775830(+) AATAAC/GAGGAA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for ACTBL2 (56775843 - 56778636 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for ACTBL2: --
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing ACTBL2
    DNA2.0 Custom Variant and Variant Library Synthesis for ACTBL2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 614835    OMIM disorders: --


    Find genes that share disorders with ACTBL2           About GenesLikeMe

    Genetic Association Database (GAD): ACTBL2

    Export disorders for ACTBL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for ACTBL2 gene, integrated from 10 sources (see all 39):
    (articles sorted by number of sources associating them with ACTBL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants. (PubMed id 22219177)1, 4 Tao S....Sun J. (Carcinogenesis 2012)
    2. Identification of a novel actin isoform in hepatocellular carcinoma. (PubMed id 16824795)1, 2 Chang K.-W.... Yeh C.-T. (Hepatol. Res. 2006)
    3. A Proteomics Strategy for the Identification of FAT10-Modified Sites by Mass Spectrometry. (PubMed id 23862649)1 Leng L....Wang J. (J. Proteome Res. 2014)
    4. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    5. Genome-wide association study of orthostatic hypotension and supine-standing blood pressure changes in two korean populations. (PubMed id 24124408)1 Hong K.W....Kim Y. (amp 2013)
    6. Profiling of Parkin-binding partners using tandem affinity purification. (PubMed id 24244333)1 Zanon A....Pichler I. (PLoS ONE 2013)
    7. Sp1 phosphorylation by cyclin-dependent kinase 1/cyclin B1 represses its DNA-binding activity during mitosis in cancer cells. (PubMed id 22266860)1 Chuang J.Y....Hung J.J. (Oncogene 2012)
    8. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    9. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)
    10. Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (J. Proteome Res. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 345651 HGNC: 17780 AceView: LOC345651 Ensembl:ENSG00000169067 euGenes: HUgn345651
    ECgene: ACTBL2 H-InvDB: ACTBL2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for ACTBL2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for ACTBL2 gene:
    Search GeneIP for patents involving ACTBL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for ACTBL2   OriGene RNAi products in human, mouse, rat for ACTBL2  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for ACTBL2  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for ACTBL2  
     OriGene qSTAR qPCR primer pairs in human, mouse for ACTBL2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for ACTBL2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ACTBL2   OriGene Custom Protein Services for ACTBL2  

     
     
     Block miRNA regulation of human, mouse, rat ACTBL2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ACTBL2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ACTBL2 Predesigned siRNA for gene silencing in human, mouse, rat ACTBL2
     QuantiFast Probe-based Assays in human, mouse, rat ACTBL2 QuantiTect SYBR Green Assays in human, mouse, rat ACTBL2
     Custom PCR Arrays for ACTBL2 Search Chromatin IP Primers for ACTBL2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ACTBL2  Search GeneGlobe Interaction Network for ACTBL2
     Regulatory tfbs in ACTBL2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for ACTBL2 GenScript cDNA clones with any tag delivered in your preferred vector for ACTBL2
     GenScript Custom Assay Services for ACTBL2 GenScript Custom overexpressing Cell Line Services for ACTBL2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for ACTBL2 (ACTBL)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Biologicals
     Novus Tissue Slides
     Antibodies for ACTBL2
     See all of Abcam's Antibodies, Kits and Proteins for ACTBL2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for ACTBL2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACTBL2
     SwitchGear 3'UTR luciferase reporter plasmids for ACTBL2
     Browse SwitchGear Promoter luciferase reporter plasmids for ACTBL2
     Search ThermoFisher Antibodies for ACTBL2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACTBL2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ACTBL2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ACTBL2
     LSBio Antibodies in human, mouse, rat for ACTBL2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for ACTBL2
      Search eBioscience for proteins for ACTBL2
      Search eBioscience for elisas for ACTBL2
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ACTBL2 gene at Home site.
    Version: 3.12.202 14 Sep 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4