Aliases for ACTB Gene
Aliases for ACTB Gene
External Ids for ACTB Gene
- HGNC: 132
- Entrez Gene: 60
- Ensembl: ENSG00000075624
- OMIM: 102630
- UniProtKB: P60709
Previous GeneCards Identifiers for ACTB Gene
- GC07M005211
- GC07M005311
- GC07M005340
- GC07M005533
- GC07M005479
- GC07M005566
Summaries for ACTB Gene
-
This gene encodes one of six different actin proteins. Actins are highly conserved proteins that are involved in cell motility, structure, integrity, and intercellular signaling. The encoded protein is a major constituent of the contractile apparatus and one of the two nonmuscle cytoskeletal actins that are ubiquitously expressed. Mutations in this gene cause Baraitser-Winter syndrome 1, which is characterized by intellectual disability with a distinctive facial appearance in human patients. Numerous pseudogenes of this gene have been identified throughout the human genome. [provided by RefSeq, Aug 2017]
GeneCards Summary for ACTB Gene
ACTB (Actin Beta) is a Protein Coding gene. Diseases associated with ACTB include Dystonia, Juvenile-Onset and Baraitser-Winter Syndrome 1. Among its related pathways are Salivary secretion and Development Slit-Robo signaling. Gene Ontology (GO) annotations related to this gene include identical protein binding and RNA polymerase II proximal promoter sequence-specific DNA binding. An important paralog of this gene is ACTG1.
UniProtKB/Swiss-Prot for ACTB Gene
-
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
-
Actin is a ubiquitous globular protein that is one of the most highly-conserved proteins known. It is found in two main states: G-actin is the globular monomeric form, whereas F-actin forms helical polymers. Both G- and F-actin are intrinsically flexible structures.
Additional gene information for ACTB Gene
- Monarch Initiative
- Search for ACTB at DataMed
- Search for ACTB at HumanCyc
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACTB Gene
Genomics for ACTB Gene
GeneHancer (GH) Regulatory Elements for ACTB Gene
Promoters and enhancers for ACTB Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around ACTB on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for ACTB Gene
Genomic Locations for ACTB Gene
- chr7:5,527,148-5,563,784
- (GRCh38/hg38)
- Size:
- 36,637 bases
- Orientation:
- Minus strand
- chr7:5,566,779-5,603,415
- (GRCh37/hg19)
Genomic View for ACTB Gene
Genes around ACTB on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 7p22.1 by Ensembl
- 7p22.1 by Entrez Gene
- 7p22.1 by HGNC
ACTB Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ACTB Gene
Proteins for ACTB Gene
-
Protein details for ACTB Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P60709-ACTB_HUMAN
- Recommended name:
- Actin, cytoplasmic 1
- Protein Accession:
- P60709
- P02570
- P70514
- P99021
- Q11211
- Q64316
- Q75MN2
- Q96B34
- Q96HG5
Protein attributes for ACTB Gene
- Size:
- 375 amino acids
- Molecular mass:
- 41737 Da
- Quaternary structure:
-
- Interacts with CPNE1 (via VWFA domain) and CPNE4 (via VWFA domain) (By similarity). Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Component of the BAF complex, which includes at least actin (ACTB), ARID1A, ARID1B/BAF250, SMARCA2, SMARCA4/BRG1, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57 SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more of SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C. In muscle cells, the BAF complex also contains DPF3. Found in a complex with XPO6, Ran, ACTB and PFN1. Component of the MLL5-L complex, at least composed of KMT2E/MLL5, STK38, PPP1CA, PPP1CB, PPP1CC, HCFC1, ACTB and OGT. Interacts with XPO6 and EMD. Interacts with ERBB2. Interacts with GCSAM. Interacts with TBC1D21 (By similarity). Interacts with DHX9 (via C-terminus); this interaction is direct and mediates the attachment to nuclear ribonucleoprotein complexes (PubMed:11687588).
- Miscellaneous:
-
- In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.
Protein Expression for ACTB Gene
Post-translational modifications for ACTB Gene
- (Microbial infection) Monomeric actin is cross-linked by V.cholerae toxins RtxA and VgrG1 in case of infection: bacterial toxins mediate the cross-link between Lys-50 of one monomer and Glu-270 of another actin monomer, resulting in formation of highly toxic actin oligomers that cause cell rounding (PubMed:19015515). The toxin can be highly efficient at very low concentrations by acting on formin homology family proteins: toxic actin oligomers bind with high affinity to formins and adversely affect both nucleation and elongation abilities of formins, causing their potent inhibition in both profilin-dependent and independent manners (PubMed:26228148).
- ISGylated.
- Monomethylation at Lys-84 (K84me1) regulates actin-myosin interaction and actomyosin-dependent processes. Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration.
- Oxidation of Met-44 and Met-47 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promote actin repolymerization (By similarity).
Other Protein References for ACTB Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for ACTB (beta-Actin)
- Cell Signaling Technology (CST) Antibodies for ACTB (ACTB)
-
Custom Antibody ServicesOriGene Antibodies for ACTB
- TA353557
- TA353556
- TA349208
- TA349205
- TA349013
- TA349012
- TA348410
- TA347340
- TA346866
- TA345667
- TA336770
- TA336690
- TA336689
- TA336477
- TA313195
- TA310155
- TA308840
- TA306308
- AP23090PU-N
- AP09293PU-N
- AP08996PU-N
- AP08869PU-N
- AP07540PU-N
- AP07457PU-N
- AP07129PU-N
- AP00310PU-N
- AM33002PU-N
- AM31715PU-N
- AM26073PU-M
- AM20786PU-N
- AM20778PU-S
- AM20778PU-N
- AM20778PU-L
- AM20709PU-S
- AM20709PU-N
- AM20687PU-N
- AM11016PU-N
- AM11015SU-N
- AM06276SU-N
- Novus Biologicals Antibodies for ACTB
-
Abcam antibodies for ACTB
-
Cloud-Clone Corp. Antibodies for ACTB
- Invitrogen Antibodies for ACTB
- antibodies-online: Search results for 621 available beta Actin Antibodies ranked by validation data
- Compare Top beta Actin Antibodies
-
Recommended
- 14 IHC (p) Antibodies (anti-human)
- 12 IF (cc) Antibodies (anti-human)
- 5 FACS Antibodies (anti-human)
- 515 WB Antibodies (anti-human)
- 1 IHC Antibody (anti-rat)
- 1 IF Antibody (anti-rat)
- 1 ICC Antibody (anti-rat)
- 2 IP Antibodies (anti-rat)
- 4 IHC (p) Antibodies (anti-rat)
- 5 FACS Antibodies (anti-rat)
- 12 IF (cc) Antibodies (anti-rat)
- 267 WB Antibodies (anti-rat)
- 1 IHC Antibody (anti-mouse)
- 2 IP Antibodies (anti-mouse)
- 2 IF Antibodies (anti-mouse)
- 2 BCA Antibodies (anti-mouse)
- 4 IHC (p) Antibodies (anti-mouse)
- 5 FACS Antibodies (anti-mouse)
- 12 IF (cc) Antibodies (anti-mouse)
- 309 WB Antibodies (anti-mouse)
- 2 IP Antibodies (anti-human)
- 2 IF Antibodies (anti-human)
- 2 BCA Antibodies (anti-human)
- 4 IHC Antibodies (anti-human)
- GeneTex ACTB antibody for ACTB
-
Custom Antibody ServicesProSci Antibodies for ACTB
-
Santa Cruz Biotechnology (SCBT) Antibodies for ACTB
- Sino Biological Antibodies for ACTB
Protein Products
-
OriGene Purified Proteins for ACTB
- Search Origene for MassSpec and Protein Over-expression Lysates for ACTB
- Origene Custom Protein Services for ACTB
-
Cloud-Clone Corp. Proteins for ACTB
- Search GeneTex for Proteins for ACTB
-
ProSci Proteins for ACTB
-
Abcam proteins for ACTB
No data available for DME Specific Peptides for ACTB Gene
Domains & Families for ACTB Gene
Gene Families for ACTB Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Disease related genes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for ACTB Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for ACTB Gene
Graphical View of Domain Structure for InterPro Entry
P60709- Family:
-
- Belongs to the actin family.
Function for ACTB Gene
Molecular function for ACTB Gene
- GENATLAS Biochemistry:
- actin,beta,cytoplasmic,major constituent of microfilaments
- UniProtKB/Swiss-Prot Function:
- Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000978 | contributes_to RNA polymerase II proximal promoter sequence-specific DNA binding | HDA,IDA | 16217013 |
| GO:0000980 | contributes_to RNA polymerase II distal enhancer sequence-specific DNA binding | IDA,HDA | 16217013 |
| GO:0005200 | structural constituent of cytoskeleton | TAS | 6202424 |
| GO:0005515 | protein binding | IPI | 11687588 |
| GO:0005524 | ATP binding | IEA | -- |
Phenotypes for ACTB Gene
- MGI mutant phenotypes for ACTB:
-
inferred from 14 alleles
- nervous system phenotype
- normal phenotype
- homeostasis/metabolism phenotype
- muscle phenotype
- cardiovascular system phenotype
- mortality/aging
- immune system phenotype
- behavior/neurological phenotype
- growth/size/body region phenotype
- neoplasm
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- vision/eye phenotype
- hearing/vestibular/ear phenotype
- embryo phenotype
- hematopoietic system phenotype
- liver/biliary system phenotype
- adipose tissue phenotype
- no phenotypic analysis
- GenomeRNAi human phenotypes for ACTB:
-
- Increased vaccinia virus (VACV) infection
- Decreased viability
- Decreased shRNA abundance (Z-score < -2)
- Increased shRNA abundance (Z-score > 2)
- Decreased IL-8 secretion
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance
- Decreased cell migration
- Weakly decreased NFAT1-GFP nuclear translocation
- Decreased homologous recombination repair frequency
Animal Models for ACTB Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for ACTB
-
-
ViGene Biosciences lentiviral particle packaged cDNA for ACTB gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ACTB gene
- Search ViGene Biosciences for ACTB
CRISPR Products
-
OriGene CRISPR knockouts for ACTB
- genomics-online: gRNA clones - Search results for 163 available beta Actin gene related products
- Overview of 163 available beta Actin gene related products
- Applied Biological Materials CRISPR for ACTB
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ACTB
- GenScript: Design CRISPR guide RNA sequences for ACTB
miRNA for ACTB Gene
- miRTarBase miRNAs that target ACTB
-
- hsa-mir-644a (MIRT007163)
- hsa-mir-1-3p (MIRT024098)
- hsa-mir-1307-3p (MIRT035818)
- hsa-mir-1303 (MIRT035877)
- hsa-mir-1295a (MIRT035901)
- hsa-mir-744-5p (MIRT037388)
- hsa-mir-455-3p (MIRT037834)
- hsa-mir-93-3p (MIRT038781)
- hsa-mir-484 (MIRT041669)
- hsa-mir-324-5p (MIRT043141)
- hsa-mir-326 (MIRT043650)
- hsa-mir-378a-3p (MIRT043906)
- hsa-mir-320a (MIRT044755)
- hsa-mir-222-3p (MIRT046589)
- hsa-mir-221-3p (MIRT046843)
- hsa-mir-196a-5p (MIRT048244)
- hsa-mir-100-5p (MIRT048522)
- hsa-mir-92a-3p (MIRT049406)
- hsa-mir-16-5p (MIRT051251)
- hsa-let-7c-5p (MIRT051732)
- hsa-let-7b-5p (MIRT051913)
- hsa-let-7a-5p (MIRT052403)
- hsa-mir-3176 (MIRT052797)
- hsa-mir-145-5p (MIRT053374)
- hsa-mir-548t-3p (MIRT222253)
- hsa-mir-548aa (MIRT222255)
- hsa-mir-548ap-3p (MIRT222256)
- hsa-mir-4282 (MIRT239825)
- hsa-mir-4698 (MIRT239826)
- hsa-mir-8063 (MIRT239827)
- hsa-mir-4289 (MIRT258433)
- hsa-mir-412-3p (MIRT441278)
- hsa-mir-544a (MIRT441279)
- hsa-mir-432-3p (MIRT441280)
- hsa-mir-493-5p (MIRT441281)
- hsa-mir-127-5p (MIRT441282)
- hsa-mir-493-3p (MIRT441283)
- hsa-mir-218-5p (MIRT441284)
- hsa-mir-5572 (MIRT482506)
- hsa-mir-4260 (MIRT482507)
- hsa-mir-450a-2-3p (MIRT482508)
- hsa-mir-3611 (MIRT482509)
- hsa-mir-6803-5p (MIRT482510)
- hsa-mir-6751-5p (MIRT482511)
- hsa-mir-7109-5p (MIRT482512)
- hsa-mir-4665-5p (MIRT482513)
- hsa-mir-1275 (MIRT482514)
- hsa-mir-19b-3p (MIRT482515)
- hsa-mir-19a-3p (MIRT482516)
- hsa-mir-5010-5p (MIRT482517)
- hsa-mir-4525 (MIRT482518)
- hsa-mir-7111-5p (MIRT482519)
- hsa-mir-6870-5p (MIRT482520)
- hsa-mir-5698 (MIRT482521)
- hsa-mir-4723-5p (MIRT482522)
- hsa-mir-6876-3p (MIRT482523)
- hsa-mir-626 (MIRT482524)
- hsa-mir-520h (MIRT482525)
- hsa-mir-520g-3p (MIRT482526)
- hsa-mir-3973 (MIRT482527)
- hsa-mir-6510-3p (MIRT482528)
- hsa-mir-3529-3p (MIRT482529)
- hsa-mir-6507-3p (MIRT482530)
- hsa-mir-937-5p (MIRT482531)
- hsa-mir-1200 (MIRT482532)
- hsa-mir-5702 (MIRT482533)
- hsa-mir-544b (MIRT482534)
- hsa-mir-4324 (MIRT482535)
- hsa-mir-4328 (MIRT482536)
- hsa-mir-3613-3p (MIRT482537)
- hsa-mir-605-5p (MIRT482538)
- hsa-mir-548z (MIRT482539)
- hsa-mir-548h-3p (MIRT482540)
- hsa-mir-548d-3p (MIRT482541)
- hsa-mir-548bb-3p (MIRT482542)
- hsa-mir-548ac (MIRT482543)
- hsa-mir-5195-3p (MIRT482544)
- hsa-mir-6772-5p (MIRT503197)
- hsa-let-7i-3p (MIRT503198)
- hsa-mir-5681a (MIRT503199)
- hsa-mir-191-3p (MIRT503200)
- hsa-mir-329-5p (MIRT503201)
- hsa-mir-4464 (MIRT503202)
- hsa-mir-4748 (MIRT503203)
- hsa-mir-3912-3p (MIRT503204)
- hsa-mir-4477a (MIRT512326)
- hsa-mir-4699-5p (MIRT512327)
- hsa-mir-525-3p (MIRT512328)
- hsa-mir-524-3p (MIRT512329)
- hsa-mir-548l (MIRT512330)
- hsa-mir-548n (MIRT512331)
- hsa-mir-506-3p (MIRT512332)
- hsa-mir-124-3p (MIRT512333)
- hsa-mir-6738-3p (MIRT513074)
- hsa-mir-192-3p (MIRT543082)
- hsa-mir-6870-3p (MIRT543083)
- hsa-mir-6872-3p (MIRT543084)
- hsa-mir-216a-5p (MIRT543085)
- hsa-mir-7-2-3p (MIRT543086)
- hsa-mir-7-1-3p (MIRT543087)
- hsa-mir-3680-3p (MIRT568637)
- hsa-mir-557 (MIRT568638)
- hsa-mir-507 (MIRT568639)
- hsa-mir-450b-5p (MIRT568640)
- hsa-mir-33b-5p (MIRT568641)
- hsa-mir-33a-5p (MIRT568642)
- hsa-mir-382-3p (MIRT568643)
miRNA Products
- Search ViGene Biosciences for ACTB
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for ACTB
- Browse OriGene Inhibitory RNA Products For ACTB
- genomics-online: shRNA clones - Search results for 163 available beta Actin gene related products
- Overview of 163 available beta Actin gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for ACTB gene
Clone Products
- Sino Biological Human cDNA Clone for ACTB
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ACTB
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ACTB
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for ACTB
- Applied Biological Materials Clones for ACTB
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- Browse cDNA clones at Cloud-Clone Corp.
-
Cloud-Clone Corp. primers for ACTB
Cell Line Products
-
Horizon Cell Lines for ACTB
-
ViGene Biosciences adenoviral particle packaged cDNA for ACTB gene
-
ViGene Biosciences lentiviral particle packaged cDNA for ACTB gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ACTB gene
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Transcription Factor Targets and HOMER Transcription for ACTB Gene
Localization for ACTB Gene
Subcellular locations from UniProtKB/Swiss-Prot for ACTB Gene
- Cytoplasm, cytoskeleton. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| cytoskeleton | 5 |
| nucleus | 5 |
| cytosol | 5 |
| plasma membrane | 4 |
| mitochondrion | 2 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000790 | nuclear chromatin | HDA,IDA | 16217013 |
| GO:0005615 | extracellular space | IDA,HDA | 16502470 |
| GO:0005634 | nucleus | IDA | 11687588 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | TAS | 16130169 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for ACTB Gene
Pathways & Interactions for ACTB Gene
Pathways by source for ACTB Gene
1 Cell Signaling Technology pathway for ACTB Gene
7 BioSystems pathways for ACTB Gene
33 Reactome pathways for ACTB Gene
30 GeneGo (Thomson Reuters) pathways for ACTB Gene
6 R&D Systems pathways for ACTB Gene
- Blood-Brain Barrier and Immune Cell Transmigration: CCL2/MCP-1 Signaling Pathways
- Blood-Brain Barrier and Immune Cell Transmigration: ICAM-1/CD54 Signaling Pathways
- Blood-Brain Barrier and Immune Cell Transmigration: Pathways Overview
- Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways
- Blood-Brain Barrier and Immune Cell Transmigration: VEGF Signaling Pathways
Interacting Proteins for ACTB Gene
Selected Interacting proteins:
ENSP00000349960
P60709-ACTB_HUMAN
for ACTB Gene via
STRING
UniProtKB
MINT
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001895 | retina homeostasis | IEP,HEP | 23580065 |
| GO:0006928 | movement of cell or subcellular component | TAS | 6202424 |
| GO:0016579 | protein deubiquitination | TAS | -- |
| GO:0021762 | substantia nigra development | HEP,IEP | 22926577 |
| GO:0032091 | negative regulation of protein binding | IEA,ISS | -- |
No data available for SIGNOR curated interactions for ACTB Gene
Drugs & Compounds for ACTB Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Latrunculin A | Experimental | Pharma | Inhibitor of actin assembly and polymerization | 0 | ||
| Quercetin | Experimental, Investigational | Nutra | Target | Antitumor agent | 42 | |
| Phenethyl isothiocyanate | Investigational | Pharma | Target | 12 | ||
| CK 666 | Pharma | 0 | ||||
| CK 869 | Pharma | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
(5) Tocris Compounds for ACTB Gene
| Compound | Action | Cas Number |
|---|---|---|
| 187-1, N-WASP inhibitor | N-WASP inhibitor; inhibits actin assembly | 380488-27-7 |
| CK 666 | Arp2/3 inhibitor; inhibits actin polymerization | 442633-00-3 |
| CK 869 | Arp2/3 inhibitor; inhibits actin polymerization | 388592-44-7 |
| Latrunculin A | Inhibitor of actin assembly and polymerization | 76343-93-6 |
| Wiskostatin | N-WASP inhibitor; inhibits Arp2/3 activation | 253449-04-6 |
(8) ApexBio Compounds for ACTB Gene
| Compound | Action | Cas Number |
|---|---|---|
| CK 666 | 442633-00-3 | |
| CK 869 | 388592-44-7 | |
| Cytochalasin D | inhibitor of actin polymerization, selective | 22144-77-0 |
| Jasplakinolide | 102396-24-7 | |
| Latrunculin A | 76343-93-6 | |
| Phalloidin | 17466-45-4 | |
| SMIFH2 | 340316-62-3 | |
| Wiskostatin | 253449-04-6 |
Transcripts for ACTB Gene
mRNA/cDNA for ACTB Gene
- (1) REFSEQ mRNAs :
- (35) Additional mRNA sequences :
- (2230) Selected AceView cDNA sequences:
- (13) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for ACTB
- genomics-online: gRNA clones - Search results for 163 available beta Actin gene related products
- Overview of 163 available beta Actin gene related products
- Applied Biological Materials CRISPR for ACTB
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ACTB
- GenScript: Design CRISPR guide RNA sequences for ACTB
miRNA Products
- Search ViGene Biosciences for ACTB
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for ACTB
- Browse OriGene Inhibitory RNA Products For ACTB
- genomics-online: shRNA clones - Search results for 163 available beta Actin gene related products
- Overview of 163 available beta Actin gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for ACTB gene
Clone Products
- Sino Biological Human cDNA Clone for ACTB
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ACTB
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ACTB
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for ACTB
- Applied Biological Materials Clones for ACTB
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- Browse cDNA clones at Cloud-Clone Corp.
-
Cloud-Clone Corp. primers for ACTB
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | · | 5c | · | 5d | · | 5e | · | 5f | ^ | 6a | · | 6b | · | 6c | ^ | 7 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||
| SP4: | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||
| SP7: | - | - | |||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | |||||||||||||||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||||||||||||||||||
| SP10: | - |
Expression for ACTB Gene
mRNA differential expression in normal tissues according to GTEx for ACTB Gene
This gene is overexpressed in Whole Blood (x4.5).
This gene is overexpressed in Neutrophil (11.1), Tlymphocyte (8.7), and Lavage (7.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ACTB Gene
NURSA nuclear receptor signaling pathways regulating expression of ACTB Gene:
ACTBSOURCE GeneReport for Unigene cluster for ACTB Gene:
Hs.520640Evidence on tissue expression from TISSUES for ACTB Gene
- Blood(5)
- Eye(5)
- Intestine(5)
- Kidney(5)
- Liver(5)
- Lung(5)
- Pancreas(5)
- Skin(5)
- Stomach(5)
- Nervous system(5)
- Muscle(4.9)
- Spleen(4.9)
- Thyroid gland(4.9)
- Bone(4.8)
- Heart(4.8)
- Bone marrow(3.6)
- Lymph node(3.6)
- Adrenal gland(3.4)
- Gall bladder(3.1)
Phenotype-based relationships between genes and organs from Gene ORGANizer for ACTB Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- immune
- integumentary
- lymphatic
- nervous
- reproductive
- respiratory
- skeletal muscle
- skeleton
- urinary
Organs:
Head and neck:
- brain
- cheek
- chin
- cranial nerve
- ear
- eye
- eyelid
- face
- forehead
- head
- jaw
- lip
- mandible
- maxilla
- mouth
- neck
- nose
- outer ear
- scalp
- skull
- tongue
Thorax:
- aorta
- esophagus
- heart
- heart valve
- lung
- rib
- rib cage
- scapula
Abdomen:
- intestine
- kidney
- large intestine
- small intestine
- stomach
Pelvis:
- pelvis
- penis
- testicle
Limb:
- ankle
- arm
- digit
- elbow
- femur
- fibula
- finger
- foot
- forearm
- hand
- hip
- humerus
- knee
- lower limb
- radius
- shin
- shoulder
- thigh
- tibia
- toe
- ulna
- upper limb
- wrist
General:
- blood
- blood vessel
- hair
- peripheral nervous system
- skin
- spinal column
- vertebrae
Primer Products
-
OriGene qPCR primer pairs for ACTB
-
OriGene qPCR primer pairs and template standards for ACTB
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for ACTB Gene
Orthologs for ACTB Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| oppossum (Monodelphis domestica) |
Mammalia | ACTB 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | ACTB 34 |
|
OneToOne | |
| chimpanzee (Pan troglodytes) |
Mammalia | ACTB 34 33 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| cow (Bos Taurus) |
Mammalia | ACTB 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | ACTB 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Actb 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Actb 16 34 33 |
|
||
| chicken (Gallus gallus) |
Aves | gga-mir-3533 34 |
|
OneToOne | |
| ACTB 33 |
|
||||
| lizard (Anolis carolinensis) |
Reptilia | ACTB 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | actb 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | actb1 34 |
|
ManyToMany | |
| bactin2 33 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | Act5C 35 |
|
|
|
| Act42A 35 |
|
|
|||
| Act57B 35 34 |
|
||||
| Act88F 35 |
|
|
|||
| Act79B 35 |
|
|
|||
| Act87E 35 33 |
|
||||
| Arp53D 35 |
|
|
|||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP005095 33 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | act-2 35 34 |
|
||
| act-1 35 |
|
|
|||
| act-3 35 |
|
|
|||
| act-5 35 |
|
|
|||
| F42C5.9 35 |
|
|
|||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | ACT1 34 36 |
|
OneToMany | |
| rice (Oryza sativa) |
Liliopsida | Os05g0438800 33 |
|
||
| Os.3420 33 |
|
||||
| barley (Hordeum vulgare) |
Liliopsida | Hv.8296 33 |
|
||
| corn (Zea mays) |
Liliopsida | Zm.6944 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSCA1 34 |
|
ManyToMany |
- Species where no ortholog for ACTB was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for ACTB Gene
Paralogs for ACTB Gene
(32) SIMAP similar genes for ACTB Gene using alignment to 9 proteins:
Pseudogenes.org Pseudogenes for ACTB Gene
Variants for ACTB Gene
| SNP ID | Clin | Chr 07 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs104894003 | pathogenic, Juvenile-onset dystonia, Baraitser-Winter syndrome 1, Dystonia, juvenile-onset (DJO) [MIM:607371] | 5,528,536(-) | G/A | coding_sequence_variant, missense_variant | |
| rs11546939 | conflicting-interpretations-of-pathogenicity, benign, not specified, Baraitser-Winter syndrome 1 | 5,528,046(-) | C/T | coding_sequence_variant, synonymous_variant | |
| rs13447397 | likely-benign, benign, not specified, Baraitser-Winter syndrome 1 | 5,529,404(-) | G/A | intron_variant | |
| rs13447407 | benign, Baraitser-Winter syndrome 1 | 5,528,085(-) | G/A/T | coding_sequence_variant, synonymous_variant | |
| rs281875331 | pathogenic, not-provided, Baraitser-Winter syndrome 1, not provided, Baraitser-Winter syndrome 1 (BRWS1) [MIM:243310] | 5,529,624(-) | T/C/G | coding_sequence_variant, missense_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv3482n106 | OTHER | inversion | 24896259 |
| esv25511 | CNV | loss | 19812545 |
| esv3571585 | CNV | loss | 25503493 |
| esv3611976 | CNV | loss | 21293372 |
| nsv436904 | CNV | insertion | 17901297 |
| nsv471304 | CNV | loss | 18288195 |
| nsv517558 | CNV | loss | 19592680 |
| nsv526194 | CNV | gain | 19592680 |
| nsv830890 | CNV | loss | 17160897 |
| nsv981426 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
11.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.06;
1.44% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ACTB Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACTB Gene
Disorders for ACTB Gene
(24) MalaCards diseases for ACTB Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| dystonia, juvenile-onset |
|
|
| baraitser-winter syndrome 1 |
|
|
| acute lymphocytic leukemia |
|
|
| lymphoblastic leukemia, acute, with lymphomatous features |
|
|
| becker nevus syndrome |
|
|
Search ACTB in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
ACTB_HUMAN- Baraitser-Winter syndrome 1 (BRWS1) [MIM:243310]: A rare developmental disorder characterized by the combination of congenital ptosis, high-arched eyebrows, hypertelorism, ocular colobomata, and a brain malformation consisting of anterior-predominant lissencephaly. Other typical features include postnatal short stature and microcephaly, intellectual disability, seizures, and hearing loss. {ECO:0000269 PubMed:22366783}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Dystonia, juvenile-onset (DJO) [MIM:607371]: A form of dystonia with juvenile onset. Dystonia is defined by the presence of sustained involuntary muscle contraction, often leading to abnormal postures. Patients with juvenile-onset dystonia manifest progressive, generalized, dopa-unresponsive dystonia, developmental malformations and sensory hearing loss. {ECO:0000269 PubMed:16685646}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Genatlas disease for ACTB Gene
recurrent infection,photosensitivity and mild mental retardation associated to abnormalities in neutrophil chemotaxis,superoxide production and membrane potential response
Additional Disease Information for ACTB
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Publications for ACTB Gene
- De novo mutations in the actin genes ACTB and ACTG1 cause Baraitser-Winter syndrome. (PMID: 22366783) Rivière JB … Dobyns WB (Nature genetics 2012) 3 4 58
- Nuclear ErbB2 enhances translation and cell growth by activating transcription of ribosomal RNA genes. (PMID: 21555369) Li LY … Hung MC (Cancer research 2011) 3 4 58
- [Establishment of a multiplex ligation-dependent SNP genotyping method and its application in the detection of genes related to chemotherapeutic drugs in breast cancer]. (PMID: 19538885) Tang JH … Xu ZY (Zhonghua zhong liu za zhi [Chinese journal of oncology] 2009) 3 44 58
- Molecular composition of IMP1 ribonucleoprotein granules. (PMID: 17289661) Jønson L … Nielsen FC (Molecular & cellular proteomics : MCP 2007) 3 4 58
- HGAL, a lymphoma prognostic biomarker, interacts with the cytoskeleton and mediates the effects of IL-6 on cell migration. (PMID: 17823310) Lu X … Lossos IS (Blood 2007) 3 4 58
Products for ACTB Gene
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- AM06276SU-N
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- AP07129PU-N
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- AP07540PU-N
- AP08869PU-N
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- AP09293PU-N
- AP23090PU-N
- TA306308
- TA308840
- TA310155
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- TA336477
- TA336689
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- TA349205
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- TA353556
- TA353557
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- VectorBuilder custom plasmid, inducible vectors for ACTB
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for ACTB
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- orf clones -