Aliases for ACTB Gene
External Ids for ACTB Gene
Previous GeneCards Identifiers for ACTB Gene
This gene encodes one of six different actin proteins. Actins are highly conserved proteins that are involved in cell motility, structure, and integrity. This actin is a major constituent of the contractile apparatus and one of the two nonmuscle cytoskeletal actins. [provided by RefSeq, Jul 2008]
GeneCards Summary for ACTB Gene
ACTB (Actin, Beta) is a Protein Coding gene. Diseases associated with ACTB include short stature - intellectual disability - eye anomalies - cleft lip/palate and developmental malformations - deafness - dystonia. Among its related pathways are Immune System and Signaling by GPCR. GO annotations related to this gene include identical protein binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is ACTRT1.
UniProtKB/Swiss-Prot for ACTB Gene
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells
Actin is a ubiquitous globular protein that is one of the most highly-conserved proteins known. It is found in two main states: G-actin is the globular monomeric form, whereas F-actin forms helical polymers. Both G- and F-actin are intrinsically flexible structures.