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Aliases for ACSS3 Gene

Aliases for ACSS3 Gene

  • Acyl-CoA Synthetase Short-Chain Family Member 3 2 3 4
  • EC 4 63
  • EC 6.2.1 63

External Ids for ACSS3 Gene

Previous GeneCards Identifiers for ACSS3 Gene

  • GC12P079995
  • GC12P081471
  • GC12P078528
  • GC12P081331

Summaries for ACSS3 Gene

GeneCards Summary for ACSS3 Gene

ACSS3 (Acyl-CoA Synthetase Short-Chain Family Member 3) is a Protein Coding gene. Diseases associated with ACSS3 include fetal alcohol syndrome. Among its related pathways are Metabolism and ethanol degradation II. GO annotations related to this gene include acetate-CoA ligase activity. An important paralog of this gene is AACS.

UniProtKB/Swiss-Prot for ACSS3 Gene

  • Activates acetate so that it can be used for lipid synthesis or for energy generation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACSS3 Gene

Genomics for ACSS3 Gene

Regulatory Elements for ACSS3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ACSS3 Gene

80,936,414 bp from pter
81,261,205 bp from pter
324,792 bases
Plus strand

Genomic View for ACSS3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ACSS3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACSS3 Gene

Proteins for ACSS3 Gene

  • Protein details for ACSS3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Acyl-CoA synthetase short-chain family member 3, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • Q8NC66

    Protein attributes for ACSS3 Gene

    686 amino acids
    Molecular mass:
    74778 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ACSS3 Gene


neXtProt entry for ACSS3 Gene

Proteomics data for ACSS3 Gene at MOPED

Post-translational modifications for ACSS3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ACSS3 Gene

Domains for ACSS3 Gene

Gene Families for ACSS3 Gene

  • ACS :Acyl-CoA synthetase family

Protein Domains for ACSS3 Gene

Suggested Antigen Peptide Sequences for ACSS3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9H6R3
  • Belongs to the ATP-dependent AMP-binding enzyme family.
genes like me logo Genes that share domains with ACSS3: view

Function for ACSS3 Gene

Molecular function for ACSS3 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA
UniProtKB/Swiss-Prot Function: Activates acetate so that it can be used for lipid synthesis or for energy generation.

Enzyme Numbers (IUBMB) for ACSS3 Gene

Gene Ontology (GO) - Molecular Function for ACSS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0003987 acetate-CoA ligase activity IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with ACSS3: view

Animal Model Products

CRISPR Products

miRNA for ACSS3 Gene

miRTarBase miRNAs that target ACSS3

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ACSS3 Gene

Localization for ACSS3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACSS3 Gene


Subcellular locations from

Jensen Localization Image for ACSS3 Gene COMPARTMENTS Subcellular localization image for ACSS3 gene
Compartment Confidence
mitochondrion 3
cytosol 2
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ACSS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with ACSS3: view

Pathways for ACSS3 Gene

genes like me logo Genes that share pathways with ACSS3: view

Pathways by source for ACSS3 Gene

Interacting Proteins for ACSS3 Gene

Gene Ontology (GO) - Biological Process for ACSS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with ACSS3: view

Transcripts for ACSS3 Gene

Unigene Clusters for ACSS3 Gene

Acyl-CoA synthetase short-chain family member 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ACSS3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ACSS3 Gene

No ASD Table

Relevant External Links for ACSS3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ACSS3 Gene

mRNA expression in normal human tissues for ACSS3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ACSS3 Gene

This gene is overexpressed in Liver (4.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ACSS3 Gene

SOURCE GeneReport for Unigene cluster for ACSS3 Gene Hs.259559

genes like me logo Genes that share expressions with ACSS3: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ACSS3 Gene

Orthologs for ACSS3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ACSS3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ACSS3 35
  • 99.27 (n)
  • 99.56 (a)
ACSS3 36
  • 100 (a)
(Bos Taurus)
Mammalia ACSS3 35
  • 89.39 (n)
  • 91.97 (a)
ACSS3 36
  • 92 (a)
(Canis familiaris)
Mammalia ACSS3 35
  • 90.74 (n)
  • 92.54 (a)
ACSS3 36
  • 95 (a)
(Mus musculus)
Mammalia Acss3 35
  • 85.95 (n)
  • 90.31 (a)
Acss3 16
Acss3 36
  • 91 (a)
(Monodelphis domestica)
Mammalia ACSS3 36
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia ACSS3 36
  • 87 (a)
(Rattus norvegicus)
Mammalia Acss3 35
  • 84.54 (n)
  • 88.66 (a)
(Gallus gallus)
Aves ACSS3 35
  • 75.99 (n)
  • 76.62 (a)
ACSS3 36
  • 73 (a)
(Anolis carolinensis)
Reptilia ACSS3 36
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia acss3 35
  • 70.83 (n)
  • 75.2 (a)
(Danio rerio)
Actinopterygii acss3 35
  • 66.03 (n)
  • 70.27 (a)
acss3 36
  • 70 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001473 35
  • 53.51 (n)
  • 50.71 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6432 35
  • 51.55 (n)
  • 47.44 (a)
CG6432 36
  • 43 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ACS2 36
  • 32 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01417 35
  • 50.9 (n)
  • 44.4 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14056 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 54 (a)
Species with no ortholog for ACSS3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ACSS3 Gene

Gene Tree for ACSS3 (if available)
Gene Tree for ACSS3 (if available)

Paralogs for ACSS3 Gene

Paralogs for ACSS3 Gene

Selected SIMAP similar genes for ACSS3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ACSS3: view

Variants for ACSS3 Gene

Sequence variations from dbSNP and Humsavar for ACSS3 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs2805 -- 81,256,730(-) TGCAG(C/T)CTTCA utr-variant-3-prime
rs10213 -- 81,256,359(-) aaaaa(A/C)attta utr-variant-3-prime
rs10860 -- 81,256,581(+) CATTA(A/C)TATCA utr-variant-3-prime
rs769056 -- 81,143,874(+) TGATG(C/T)GTCAA intron-variant
rs769057 -- 81,144,085(+) AGATT(A/G)CTATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ACSS3 Gene

Variant ID Type Subtype PubMed ID
esv2746118 CNV Deletion 23290073

Relevant External Links for ACSS3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACSS3 Gene

Disorders for ACSS3 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for ACSS3 Gene including...

Search for ACSS3 Gene in MalaCards »

(1) University of Copenhagen DISEASES for ACSS3 Gene

Relevant External Links for ACSS3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with ACSS3: view

No data available for UniProtKB/Swiss-Prot for ACSS3 Gene

Publications for ACSS3 Gene

  1. Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome. (PMID: 17762044) Watkins P.A. … Pevsner J. (J. Lipid Res. 2007) 2 3 4
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  3. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3
  4. A genome-wide association study of a sustained pattern of antidepressant response. (PMID: 23726668) Hunter A.M. … Hamilton S.P. (J Psychiatr Res 2013) 3
  5. A genome-wide association meta-analysis of plasma AI^ peptides concentrations in the elderly. (PMID: 24535457) Chouraki V. … Lambert J.C. (Mol. Psychiatry 2014) 3

Products for ACSS3 Gene

Sources for ACSS3 Gene

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