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Aliases for ACSS3 Gene

Aliases for ACSS3 Gene

  • Acyl-CoA Synthetase Short Chain Family Member 3 2 3 5
  • EC 6.2.1.1 4 58
  • Acyl-CoA Synthetase Short-Chain Family Member 3 4
  • EC 6.2.1 58

External Ids for ACSS3 Gene

Previous GeneCards Identifiers for ACSS3 Gene

  • GC12P079995
  • GC12P081471
  • GC12P078528
  • GC12P081331

Summaries for ACSS3 Gene

GeneCards Summary for ACSS3 Gene

ACSS3 (Acyl-CoA Synthetase Short Chain Family Member 3) is a Protein Coding gene. Among its related pathways are Ketone body metabolism and ethanol degradation IV. GO annotations related to this gene include acetate-CoA ligase activity. An important paralog of this gene is ACSS2.

UniProtKB/Swiss-Prot for ACSS3 Gene

  • Activates acetate so that it can be used for lipid synthesis or for energy generation.

Additional gene information for ACSS3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACSS3 Gene

Genomics for ACSS3 Gene

Regulatory Elements for ACSS3 Gene

Enhancers for ACSS3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12H081076 1 ENCODE 19.6 +142.2 142216 3 PKNOX1 FOXA2 ATF1 ZFP64 ARID4B SIN3A YY1 ATF7 SP5 KAT8 ACSS3 ENSG00000258026 LIN7A
GH12H081080 0.8 Ensembl ENCODE 19.8 +144.4 144400 0 JUND GATA3 TAF1 HNF4A REST RAD21 TCF7L2 ACSS3 ENSG00000258026 LIN7A
GH12H081095 0.4 ENCODE 11.4 +158.7 158723 0 BCL6B ACSS3 ENSG00000258026 LIN7A
GH12H081387 0.4 dbSUPER 8.8 +451.5 451505 0 CEBPG ACSS3 ENSG00000258162 GC12P081435
GH12H081409 0.2 dbSUPER 6.5 +473.7 473676 0 ACSS3 GC12P081435 ENSG00000258162
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ACSS3 on UCSC Golden Path with GeneCards custom track

Promoters for ACSS3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000054588 886 2201 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 GLIS2 ZNF143 SP3 REST

Genomic Location for ACSS3 Gene

Chromosome:
12
Start:
80,936,414 bp from pter
End:
81,261,205 bp from pter
Size:
324,792 bases
Orientation:
Plus strand

Genomic View for ACSS3 Gene

Genes around ACSS3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACSS3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACSS3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACSS3 Gene

Proteins for ACSS3 Gene

  • Protein details for ACSS3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H6R3-ACSS3_HUMAN
    Recommended name:
    Acyl-CoA synthetase short-chain family member 3, mitochondrial
    Protein Accession:
    Q9H6R3
    Secondary Accessions:
    • Q8NC66

    Protein attributes for ACSS3 Gene

    Size:
    686 amino acids
    Molecular mass:
    74778 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ACSS3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ACSS3 Gene

Selected DME Specific Peptides for ACSS3 Gene

Q9H6R3:
  • DPERFWGKAAEQISWYKPWTKTLE
  • MLACARIGA
  • ILYTSGTTG
  • VADCAVVGKED
  • RIGAIHS
  • YKEVLEQVSKLAGVLVK
  • GDKIAIIYDSPVT
  • SVTDPERFW
  • VPGYNVMILDDNMQKLKAR
  • RVDDVINV
  • VLEEIVKHVRQ
  • VVIYMPM

Post-translational modifications for ACSS3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for ACSS3 Gene

Gene Families for ACSS3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Protein Domains for ACSS3 Gene

Suggested Antigen Peptide Sequences for ACSS3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H6R3

UniProtKB/Swiss-Prot:

ACSS3_HUMAN :
  • Belongs to the ATP-dependent AMP-binding enzyme family.
Family:
  • Belongs to the ATP-dependent AMP-binding enzyme family.
genes like me logo Genes that share domains with ACSS3: view

Function for ACSS3 Gene

Molecular function for ACSS3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.
UniProtKB/Swiss-Prot Function:
Activates acetate so that it can be used for lipid synthesis or for energy generation.

Enzyme Numbers (IUBMB) for ACSS3 Gene

Phenotypes From GWAS Catalog for ACSS3 Gene

Gene Ontology (GO) - Molecular Function for ACSS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
GO:0003987 acetate-CoA ligase activity TAS --
GO:0005524 ATP binding IEA --
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with ACSS3: view

Phenotypes for ACSS3 Gene

GenomeRNAi human phenotypes for ACSS3:
genes like me logo Genes that share phenotypes with ACSS3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ACSS3

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ACSS3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ACSS3 Gene

Localization for ACSS3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACSS3 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ACSS3 gene
Compartment Confidence
mitochondrion 5
cytosol 2
extracellular 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ACSS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005759 mitochondrial matrix TAS --
genes like me logo Genes that share ontologies with ACSS3: view

Pathways & Interactions for ACSS3 Gene

genes like me logo Genes that share pathways with ACSS3: view

Gene Ontology (GO) - Biological Process for ACSS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
GO:0046951 ketone body biosynthetic process TAS --
genes like me logo Genes that share ontologies with ACSS3: view

No data available for SIGNOR curated interactions for ACSS3 Gene

Drugs & Compounds for ACSS3 Gene

(6) Drugs for ACSS3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
acetic acid Approved Nutra Full agonist, Agonist 115
Adenosine monophosphate Approved Nutra 0
propanoic acid Experimental Pharma Full agonist, Agonist 0
Propanoyl-CoA Experimental Pharma 0
ATP Nutra Agonist 0

(3) Additional Compounds for ACSS3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
acetyl-coa
  • Ac-CoA
  • Ac-Coenzyme A
  • Ac-S-CoA
  • Ac-S-Coenzyme A
  • Acetyl coenzyme-A
72-89-9
Propinol adenylate
  • Propionyladenylate
pyrophosphate
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
14000-31-8
genes like me logo Genes that share compounds with ACSS3: view

Transcripts for ACSS3 Gene

Unigene Clusters for ACSS3 Gene

Acyl-CoA synthetase short-chain family member 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ACSS3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ACSS3 Gene

No ASD Table

Relevant External Links for ACSS3 Gene

GeneLoc Exon Structure for
ACSS3
ECgene alternative splicing isoforms for
ACSS3

Expression for ACSS3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ACSS3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ACSS3 Gene

This gene is overexpressed in Liver (x4.9).

Protein differential expression in normal tissues from HIPED for ACSS3 Gene

This gene is overexpressed in Liver (13.4), Kidney (8.6), Gallbladder (7.5), and Salivary gland (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ACSS3 Gene



Protein tissue co-expression partners for ACSS3 Gene

NURSA nuclear receptor signaling pathways regulating expression of ACSS3 Gene:

ACSS3

SOURCE GeneReport for Unigene cluster for ACSS3 Gene:

Hs.259559

Evidence on tissue expression from TISSUES for ACSS3 Gene

  • Liver(4.4)
  • Muscle(4.2)
genes like me logo Genes that share expression patterns with ACSS3: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ACSS3 Gene

Orthologs for ACSS3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ACSS3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ACSS3 33 34
  • 99.27 (n)
dog
(Canis familiaris)
Mammalia ACSS3 33 34
  • 90.74 (n)
cow
(Bos Taurus)
Mammalia ACSS3 33 34
  • 89.39 (n)
oppossum
(Monodelphis domestica)
Mammalia ACSS3 34
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ACSS3 34
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Acss3 33 16 34
  • 85.95 (n)
rat
(Rattus norvegicus)
Mammalia Acss3 33
  • 84.54 (n)
chicken
(Gallus gallus)
Aves ACSS3 33 34
  • 75.99 (n)
lizard
(Anolis carolinensis)
Reptilia ACSS3 34
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia acss3 33
  • 70.83 (n)
zebrafish
(Danio rerio)
Actinopterygii acss3 33 34
  • 66.03 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001473 33
  • 53.51 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG6432 33 34
  • 51.55 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ACS2 34
  • 32 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 54 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU01417 33
  • 50.9 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14056 33
Species where no ortholog for ACSS3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ACSS3 Gene

ENSEMBL:
Gene Tree for ACSS3 (if available)
TreeFam:
Gene Tree for ACSS3 (if available)

Paralogs for ACSS3 Gene

Paralogs for ACSS3 Gene

(5) SIMAP similar genes for ACSS3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ACSS3: view

Variants for ACSS3 Gene

Sequence variations from dbSNP and Humsavar for ACSS3 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000012872 -- 81,109,449(+) CACTA(A/G)GAAAC intron-variant, upstream-variant-2KB
rs1000024891 -- 81,150,623(+) CTCTC(A/G)AATAC intron-variant
rs1000028720 -- 81,233,825(+) GGATT(A/T)AACAT intron-variant
rs1000031933 -- 81,233,564(+) AATTA(C/T)CACAC intron-variant
rs1000037375 -- 81,249,370(+) TTAAG(G/T)GTAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ACSS3 Gene

Variant ID Type Subtype PubMed ID
esv2746118 CNV deletion 23290073
esv3630129 CNV loss 21293372
esv3630130 CNV loss 21293372
esv3892231 CNV gain 25118596
nsv559465 CNV loss 21841781
nsv559466 CNV loss 21841781
nsv559467 CNV gain 21841781

Variation tolerance for ACSS3 Gene

Residual Variation Intolerance Score: 13.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.07; 60.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ACSS3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ACSS3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACSS3 Gene

Disorders for ACSS3 Gene

Relevant External Links for ACSS3

Genetic Association Database (GAD)
ACSS3
Human Genome Epidemiology (HuGE) Navigator
ACSS3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ACSS3

No disorders were found for ACSS3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ACSS3 Gene

Publications for ACSS3 Gene

  1. Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome. (PMID: 17762044) Watkins PA … Pevsner J (Journal of lipid research 2007) 2 3 4 60
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  3. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y … Zou H (Journal of proteomics 2014) 4 60
  4. A genome-wide association meta-analysis of plasma Aβ peptides concentrations in the elderly. (PMID: 24535457) Chouraki V … Lambert JC (Molecular psychiatry 2014) 3 60
  5. Electronic medical records and genomics (eMERGE) network exploration in cataract: several new potential susceptibility loci. (PMID: 25352737) Ritchie MD … McCarty CA (Molecular vision 2014) 3 60

Products for ACSS3 Gene

Sources for ACSS3 Gene

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