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Aliases for ACSS3 Gene

Aliases for ACSS3 Gene

  • Acyl-CoA Synthetase Short-Chain Family Member 3 2 3 4 5
  • EC 4 63
  • EC 6.2.1 63

External Ids for ACSS3 Gene

Previous GeneCards Identifiers for ACSS3 Gene

  • GC12P079995
  • GC12P081471
  • GC12P078528
  • GC12P081331

Summaries for ACSS3 Gene

GeneCards Summary for ACSS3 Gene

ACSS3 (Acyl-CoA Synthetase Short-Chain Family Member 3) is a Protein Coding gene. Among its related pathways are ethanol degradation IV and Metabolism. GO annotations related to this gene include acetate-CoA ligase activity. An important paralog of this gene is AACS.

UniProtKB/Swiss-Prot for ACSS3 Gene

  • Activates acetate so that it can be used for lipid synthesis or for energy generation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACSS3 Gene

Genomics for ACSS3 Gene

Regulatory Elements for ACSS3 Gene

Enhancers for ACSS3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ACSS3 on UCSC Golden Path with GeneCards custom track

Promoters for ACSS3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ACSS3 on UCSC Golden Path with GeneCards custom track

Genomic Location for ACSS3 Gene

80,936,414 bp from pter
81,261,205 bp from pter
324,792 bases
Plus strand

Genomic View for ACSS3 Gene

Genes around ACSS3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACSS3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACSS3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACSS3 Gene

Proteins for ACSS3 Gene

  • Protein details for ACSS3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Acyl-CoA synthetase short-chain family member 3, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • Q8NC66

    Protein attributes for ACSS3 Gene

    686 amino acids
    Molecular mass:
    74778 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ACSS3 Gene


neXtProt entry for ACSS3 Gene

Proteomics data for ACSS3 Gene at MOPED

Post-translational modifications for ACSS3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ACSS3 Gene

Domains & Families for ACSS3 Gene

Gene Families for ACSS3 Gene

Protein Domains for ACSS3 Gene

Suggested Antigen Peptide Sequences for ACSS3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ATP-dependent AMP-binding enzyme family.
  • Belongs to the ATP-dependent AMP-binding enzyme family.
genes like me logo Genes that share domains with ACSS3: view

Function for ACSS3 Gene

Molecular function for ACSS3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.
UniProtKB/Swiss-Prot Function:
Activates acetate so that it can be used for lipid synthesis or for energy generation.

Enzyme Numbers (IUBMB) for ACSS3 Gene

Animal Model Products

  • Taconic Biosciences Mouse Models for ACSS3

CRISPR Products

No data available for Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ACSS3 Gene

Localization for ACSS3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACSS3 Gene


Subcellular locations from

Jensen Localization Image for ACSS3 Gene COMPARTMENTS Subcellular localization image for ACSS3 gene
Compartment Confidence
mitochondrion 5
cytosol 2
extracellular 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for ACSS3 Gene

Pathways & Interactions for ACSS3 Gene

genes like me logo Genes that share pathways with ACSS3: view

Pathways by source for ACSS3 Gene

Interacting Proteins for ACSS3 Gene

Gene Ontology (GO) - Biological Process for ACSS3 Gene


No data available for SIGNOR curated interactions for ACSS3 Gene

Drugs & Compounds for ACSS3 Gene

(7) Drugs for ACSS3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
acetic acid Approved Nutra Full agonist, Agonist 97
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0
Diphosphate Experimental Pharma 0
propanoic acid Experimental Pharma Full agonist, Agonist 0

(2) Additional Compounds for ACSS3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Ac-CoA
  • Ac-Coenzyme A
  • Ac-S-CoA
  • Ac-S-Coenzyme A
  • Acetyl coenzyme-A
Propinol adenylate
  • Propionyladenylate
genes like me logo Genes that share compounds with ACSS3: view

Transcripts for ACSS3 Gene

Unigene Clusters for ACSS3 Gene

Acyl-CoA synthetase short-chain family member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ACSS3 Gene

No ASD Table

Relevant External Links for ACSS3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ACSS3 Gene

mRNA expression in normal human tissues for ACSS3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ACSS3 Gene

This gene is overexpressed in Liver (x4.9).

Protein differential expression in normal tissues from HIPED for ACSS3 Gene

This gene is overexpressed in Liver (13.4), Kidney (8.6), Gallbladder (7.5), and Salivary gland (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ACSS3 Gene

SOURCE GeneReport for Unigene cluster for ACSS3 Gene Hs.259559

genes like me logo Genes that share expression patterns with ACSS3: view

Protein tissue co-expression partners for ACSS3 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for ACSS3 Gene

Orthologs for ACSS3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ACSS3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ACSS3 35
  • 89.39 (n)
  • 91.97 (a)
ACSS3 36
  • 92 (a)
(Canis familiaris)
Mammalia ACSS3 35
  • 90.74 (n)
  • 92.54 (a)
ACSS3 36
  • 95 (a)
(Mus musculus)
Mammalia Acss3 35
  • 85.95 (n)
  • 90.31 (a)
Acss3 16
Acss3 36
  • 91 (a)
(Pan troglodytes)
Mammalia ACSS3 35
  • 99.27 (n)
  • 99.56 (a)
ACSS3 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Acss3 35
  • 84.54 (n)
  • 88.66 (a)
(Monodelphis domestica)
Mammalia ACSS3 36
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia ACSS3 36
  • 87 (a)
(Gallus gallus)
Aves ACSS3 35
  • 75.99 (n)
  • 76.62 (a)
ACSS3 36
  • 73 (a)
(Anolis carolinensis)
Reptilia ACSS3 36
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia acss3 35
  • 70.83 (n)
  • 75.2 (a)
(Danio rerio)
Actinopterygii acss3 35
  • 66.03 (n)
  • 70.27 (a)
acss3 36
  • 70 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001473 35
  • 53.51 (n)
  • 50.71 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6432 35
  • 51.55 (n)
  • 47.44 (a)
CG6432 36
  • 43 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ACS2 36
  • 32 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14056 35
bread mold
(Neurospora crassa)
Ascomycetes NCU01417 35
  • 50.9 (n)
  • 44.4 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 54 (a)
Species with no ortholog for ACSS3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ACSS3 Gene

Gene Tree for ACSS3 (if available)
Gene Tree for ACSS3 (if available)

Paralogs for ACSS3 Gene

Paralogs for ACSS3 Gene

(5) SIMAP similar genes for ACSS3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ACSS3: view

Variants for ACSS3 Gene

Sequence variations from dbSNP and Humsavar for ACSS3 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1921035 -- 81,208,670(+) TTTAC(A/G)AAACC intron-variant
rs1921036 -- 81,212,083(+) CTTTC(C/T)TGTTC intron-variant
rs1921038 -- 81,233,459(-) ATGGC(A/G)CCTGC nc-transcript-variant, reference, synonymous-codon
rs1921055 -- 81,248,302(+) tcaac(C/T)taagc intron-variant
rs1921056 -- 81,248,713(+) tggaa(C/T)gtttt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ACSS3 Gene

Variant ID Type Subtype PubMed ID
esv2746118 CNV Deletion 23290073

Variation tolerance for ACSS3 Gene

Residual Variation Intolerance Score: 13.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.07; 60.83% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ACSS3 Gene

Disorders for ACSS3 Gene

Relevant External Links for ACSS3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ACSS3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ACSS3 Gene

Publications for ACSS3 Gene

  1. Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome. (PMID: 17762044) Watkins P.A. … Pevsner J. (J. Lipid Res. 2007) 2 3 4 67
  2. A genome-wide association meta-analysis of plasma AI^ peptides concentrations in the elderly. (PMID: 24535457) Chouraki V. … Lambert J.C. (Mol. Psychiatry 2014) 3
  3. Electronic medical records and genomics (eMERGE) network exploration in cataract: several new potential susceptibility loci. (PMID: 25352737) Ritchie M.D. … McCarty C.A. (Mol. Vis. 2014) 3
  4. A genome-wide association study of a sustained pattern of antidepressant response. (PMID: 23726668) Hunter A.M. … Hamilton S.P. (J Psychiatr Res 2013) 3
  5. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3

Products for ACSS3 Gene

Sources for ACSS3 Gene