Aliases for ACSS2 Gene
External Ids for ACSS2 Gene
Previous HGNC Symbols for ACSS2 Gene
Previous GeneCards Identifiers for ACSS2 Gene
This gene encodes a cytosolic enzyme that catalyzes the activation of acetate for use in lipid synthesis and energy generation. The protein acts as a monomer and produces acetyl-CoA from acetate in a reaction that requires ATP. Expression of this gene is regulated by sterol regulatory element-binding proteins, transcription factors that activate genes required for the synthesis of cholesterol and unsaturated fatty acids. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009]
GeneCards Summary for ACSS2 Gene
ACSS2 (Acyl-CoA Synthetase Short-Chain Family Member 2) is a Protein Coding gene. Among its related pathways are Amino Acid conjugation and Signaling events mediated by HDAC Class III. GO annotations related to this gene include AMP binding and acetate-CoA ligase activity. An important paralog of this gene is ACSS1.
UniProtKB/Swiss-Prot for ACSS2 Gene
Activates acetate so that it can be used for lipid synthesis or for energy generation.