Aliases for ACSS2 Gene
External Ids for ACSS2 Gene
Previous HGNC Symbols for ACSS2 Gene
Previous GeneCards Identifiers for ACSS2 Gene
This gene encodes a cytosolic enzyme that catalyzes the activation of acetate for use in lipid synthesis and energy generation. The protein acts as a monomer and produces acetyl-CoA from acetate in a reaction that requires ATP. Expression of this gene is regulated by sterol regulatory element-binding proteins, transcription factors that activate genes required for the synthesis of cholesterol and unsaturated fatty acids. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009]
GeneCards Summary for ACSS2 Gene
ACSS2 (Acyl-CoA Synthetase Short-Chain Family Member 2) is a Protein Coding gene. Diseases associated with ACSS2 include Cystoisosporiasis. Among its related pathways are Pyruvate metabolism and ethanol degradation II. GO annotations related to this gene include AMP binding and acetate-CoA ligase activity. An important paralog of this gene is ACSS1.
UniProtKB/Swiss-Prot for ACSS2 Gene
Activates acetate so that it can be used for lipid synthesis or for energy generation.