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Aliases for ACSS2 Gene

Aliases for ACSS2 Gene

  • Acyl-CoA Synthetase Short-Chain Family Member 2 2 3 4
  • ACS 3 4 6
  • Acetyl-Coenzyme A Synthetase 2 (ADP Forming) 2 3
  • Acyl-Activating Enzyme 3 4
  • EC 6.2.1.1 4 63
  • ACECS 3 4
  • ACAS2 3 4
  • Acetyl-Coenzyme A Synthetase, Cytoplasmic 3
  • Cytoplasmic Acetyl-Coenzyme A Synthetase 3
  • Acetyl-CoA Synthetase 4
  • Acetate--CoA Ligase 4
  • Acetate Thiokinase 3
  • Acetate-CoA Ligase 3
  • DJ1161H23.1 3
  • EC 6.2.1 63
  • ACSA 3

External Ids for ACSS2 Gene

Previous HGNC Symbols for ACSS2 Gene

  • ACAS2

Previous GeneCards Identifiers for ACSS2 Gene

  • GC20P032927
  • GC20P033459
  • GC20P030241

Summaries for ACSS2 Gene

Entrez Gene Summary for ACSS2 Gene

  • This gene encodes a cytosolic enzyme that catalyzes the activation of acetate for use in lipid synthesis and energy generation. The protein acts as a monomer and produces acetyl-CoA from acetate in a reaction that requires ATP. Expression of this gene is regulated by sterol regulatory element-binding proteins, transcription factors that activate genes required for the synthesis of cholesterol and unsaturated fatty acids. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009]

GeneCards Summary for ACSS2 Gene

ACSS2 (Acyl-CoA Synthetase Short-Chain Family Member 2) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include AMP binding and acetate-CoA ligase activity. An important paralog of this gene is ACSM2B.

UniProtKB/Swiss-Prot for ACSS2 Gene

  • Activates acetate so that it can be used for lipid synthesis or for energy generation

Gene Wiki entry for ACSS2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACSS2 Gene

Genomics for ACSS2 Gene

Regulatory Elements for ACSS2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ACSS2 Gene

Start:
34,872,146 bp from pter
End:
34,927,966 bp from pter
Size:
55,821 bases
Orientation:
Plus strand

Genomic View for ACSS2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ACSS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACSS2 Gene

Proteins for ACSS2 Gene

  • Protein details for ACSS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NR19-ACSA_HUMAN
    Recommended name:
    Acetyl-coenzyme A synthetase, cytoplasmic
    Protein Accession:
    Q9NR19
    Secondary Accessions:
    • A6NE90
    • Q5QPH2
    • Q5QPH3
    • Q8N238
    • Q96EL0
    • Q9NQP7
    • Q9UJ15

    Protein attributes for ACSS2 Gene

    Size:
    701 amino acids
    Molecular mass:
    78580 Da
    Quaternary structure:
    • Monomer

    Alternative splice isoforms for ACSS2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ACSS2 Gene

Proteomics data for ACSS2 Gene at MOPED

Post-translational modifications for ACSS2 Gene

  • Ubiquitination at Lys418
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ACSS2 (ACSS2)

Domains for ACSS2 Gene

Gene Families for ACSS2 Gene

HGNC:
  • ACS :Acyl-CoA synthetase family

Protein Domains for ACSS2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NR19

UniProtKB/Swiss-Prot:

ACSA_HUMAN :
  • Q9NR19
Family:
  • Belongs to the ATP-dependent AMP-binding enzyme family.
genes like me logo Genes that share domains with ACSS2: view

Function for ACSS2 Gene

Molecular function for ACSS2 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA
UniProtKB/Swiss-Prot Function: Activates acetate so that it can be used for lipid synthesis or for energy generation

Enzyme Numbers (IUBMB) for ACSS2 Gene

Gene Ontology (GO) - Molecular Function for ACSS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0003987 acetate-CoA ligase activity IDA 10843999
GO:0005524 ATP binding IEA --
GO:0016208 AMP binding IC 10843999
genes like me logo Genes that share ontologies with ACSS2: view

Phenotypes for ACSS2 Gene

genes like me logo Genes that share phenotypes with ACSS2: view

Animal Model Products

CRISPR Products

miRNA for ACSS2 Gene

miRTarBase miRNAs that target ACSS2

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for ACSS2 Gene

Localization for ACSS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACSS2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ACSS2 Gene COMPARTMENTS Subcellular localization image for ACSS2 gene
Compartment Confidence
cytosol 4
nucleus 4
mitochondrion 2
peroxisome 2
chloroplast 1
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ACSS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with ACSS2: view

Pathways for ACSS2 Gene

genes like me logo Genes that share pathways with ACSS2: view

Gene Ontology (GO) - Biological Process for ACSS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006069 ethanol oxidation TAS --
GO:0006085 acetyl-CoA biosynthetic process --
GO:0006805 xenobiotic metabolic process TAS --
GO:0008152 metabolic process --
GO:0008610 lipid biosynthetic process IMP 10843999
genes like me logo Genes that share ontologies with ACSS2: view

Compounds for ACSS2 Gene

(11) HMDB Compounds for ACSS2 Gene

Compound Synonyms Cas Number PubMed IDs
Acetic acid
  • Acetate
64-19-7
Acetyl adenylate
  • 5'-O-[acetoxy(hydroxy)phosphoryl]adenosine
13015-87-7
Acetyl-CoA
  • S-Acetyl coenzyme A
72-89-9
Adenosine monophosphate
  • 5'-AMP
61-19-8
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5

(2) Drugbank Compounds for ACSS2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Adenosine monophosphate
  • 5'-Adenosine monophosphate
61-19-8 target product of
Adenosine triphosphate
  • 5'-ATP
56-65-5 target

(23) Novoseek inferred chemical compound relationships for ACSS2 Gene

Compound -log(P) Hits PubMed IDs
acetyl-coa 92.2 75
acyl-coa 79.1 10
pyruvate 59.6 3
propionate 54 2
fatty acid 53 5
genes like me logo Genes that share compounds with ACSS2: view

Transcripts for ACSS2 Gene

Unigene Clusters for ACSS2 Gene

Acyl-CoA synthetase short-chain family member 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ACSS2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ACSS2 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a ·
SP1: - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - -
SP4: - - - - - - - - - - - - -
SP5: - - - - - - - - - - - - - - - - - - - -
SP6: -
SP7: -
SP8:
SP9:
SP10: - - - - - -
SP11:
SP12:

ExUns: 19b · 19c ^ 20 ^ 21 ^ 22 ^ 23a · 23b · 23c
SP1:
SP2:
SP3:
SP4:
SP5: -
SP6:
SP7:
SP8: -
SP9:
SP10:
SP11:
SP12:

Relevant External Links for ACSS2 Gene

GeneLoc Exon Structure for
ACSS2
ECgene alternative splicing isoforms for
ACSS2

Expression for ACSS2 Gene

mRNA expression in normal human tissues for ACSS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ACSS2 Gene

SOURCE GeneReport for Unigene cluster for ACSS2 Gene Hs.517034

genes like me logo Genes that share expressions with ACSS2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ACSS2 Gene

Orthologs for ACSS2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ACSS2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ACSS2 35
  • 99.77 (n)
  • 99.58 (a)
ACSS2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ACSS2 35
  • 91.16 (n)
  • 94.01 (a)
ACSS2 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ACSS2 35
  • 91.46 (n)
  • 93.42 (a)
ACSS2 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Acss2 35
  • 90.58 (n)
  • 93.58 (a)
Acss2 16
Acss2 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ACSS2 36
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Acss2 35
  • 90.58 (n)
  • 93.72 (a)
chicken
(Gallus gallus)
Aves ACSS2 35
  • 74.55 (n)
  • 79.25 (a)
ACSS2 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ACSS2 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia acss2 35
  • 71.15 (n)
  • 77.78 (a)
zebrafish
(Danio rerio)
Actinopterygii acss2 36
  • 74 (a)
OneToOne
Dr.14648 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006569 35
  • 63.73 (n)
  • 64.19 (a)
fruit fly
(Drosophila melanogaster)
Insecta AcCoAS 35
  • 62.96 (n)
  • 64.18 (a)
AcCoAS 36
  • 63 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea acs-19 35
  • 55.67 (n)
  • 54.14 (a)
acs-19 36
  • 52 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ACS1 36
  • 42 (a)
OneToMany
soybean
(Glycine max)
eudicotyledons Gma.1473 35
thale cress
(Arabidopsis thaliana)
eudicotyledons ACS 35
  • 58.24 (n)
  • 59.84 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.487 35
corn
(Zea mays)
Liliopsida Zm.3669 35
rice
(Oryza sativa)
Liliopsida Os.8565 35
Os02g0525900 35
  • 59.66 (n)
  • 59.04 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.16490 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2696 36
  • 65 (a)
OneToOne
Species with no ortholog for ACSS2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for ACSS2 Gene

ENSEMBL:
Gene Tree for ACSS2 (if available)
TreeFam:
Gene Tree for ACSS2 (if available)

Paralogs for ACSS2 Gene

Paralogs for ACSS2 Gene

genes like me logo Genes that share paralogs with ACSS2: view

Variants for ACSS2 Gene

Sequence variations from dbSNP and Humsavar for ACSS2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs9547 -- 34,927,635(-) AAATT(A/G)TTCCT utr-variant-3-prime
rs926734 -- 34,903,897(-) ACCCC(A/C)CAACT intron-variant
rs1013677 -- 34,880,990(+) gttac(A/G)gttct intron-variant
rs1060615 -- 34,890,578(+) TTCTG(A/G)TCATT intron-variant
rs1062891 -- 34,927,884(+) ACATT(C/T)TCAGA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ACSS2 Gene

Variant ID Type Subtype PubMed ID
nsv912860 CNV Gain 21882294
esv271518 CNV Insertion 20981092
esv2520076 CNV Deletion 19546169
esv2722357 CNV Deletion 23290073
esv2743305 CNV Deletion 23290073
esv2671024 CNV Deletion 23128226
dgv95n6 CNV Loss 16902084
nsv833962 CNV Loss 17160897

Relevant External Links for ACSS2 Gene

HapMap Linkage Disequilibrium report
ACSS2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACSS2 Gene

Disorders for ACSS2 Gene

Relevant External Links for ACSS2

Genetic Association Database (GAD)
ACSS2
Human Genome Epidemiology (HuGE) Navigator
ACSS2
genes like me logo Genes that share disorders with ACSS2: view

No data available for UniProtKB/Swiss-Prot for ACSS2 Gene

Publications for ACSS2 Gene

  1. Molecular characterization of human acetyl-CoA synthetase, an enzyme regulated by sterol regulatory element-binding proteins. (PMID: 10843999) Luong A. … Goldstein J.L. (J. Biol. Chem. 2000) 2 3 4 23
  2. Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2. (PMID: 16788062) Schwer B. … Verdin E. (Proc. Natl. Acad. Sci. U.S.A. 2006) 3 23
  3. Identification of type 2 diabetes-associated combination of SNPs using support vector machine. (PMID: 20416077) Ban H.J. … Park K.J. (BMC Genet. 2010) 3 48
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48
  5. The importance of acetyl coenzyme A synthetase for 11C-acetate uptake and cell survival in hepatocellular carcinoma. (PMID: 19617323) Yun M. … Lee J.D. (J. Nucl. Med. 2009) 3 23

Products for ACSS2 Gene

Sources for ACSS2 Gene

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