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ACSS2 Gene

protein-coding   GIFtS: 62
GCID: GC20P033459

Acyl-CoA Synthetase Short-Chain Family Member 2

(Previous name: acetyl-Coenzyme A synthetase 2 (ADP forming))
(Previous symbol: ACAS2)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Acyl-CoA Synthetase Short-Chain Family Member 21 2 3     Acetate-CoA Ligase2
ACAS21 2 3     Acetyl-Coenzyme A Synthetase, Cytoplasmic2
ACS2 3 5     Cytoplasmic Acetyl-Coenzyme A Synthetase2
Acetyl-Coenzyme A Synthetase 2 (ADP Forming)1 2     dJ1161H23.12
Acyl-Activating Enzyme2 3     AceCS3
EC 6.2.1.13 8     Acetate--CoA Ligase3
ACECS2     Acetyl-CoA Synthetase3
ACSA2     EC 6.2.18
Acetate Thiokinase2     

External Ids:    HGNC: 158141   Entrez Gene: 559022   Ensembl: ENSG000001310697   OMIM: 6058325   UniProtKB: Q9NR193   

Export aliases for ACSS2 gene to outside databases

Previous GC identifers: GC20P032927 GC20P030241


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ACSS2 Gene:
This gene encodes a cytosolic enzyme that catalyzes the activation of acetate for use in lipid synthesis and
energy generation. The protein acts as a monomer and produces acetyl-CoA from acetate in a reaction that requires
ATP. Expression of this gene is regulated by sterol regulatory element-binding proteins, transcription factors
that activate genes required for the synthesis of cholesterol and unsaturated fatty acids. Alternative splicing
results in multiple transcript variants. (provided by RefSeq, Jul 2009)

GeneCards Summary for ACSS2 Gene:
ACSS2 (acyl-CoA synthetase short-chain family member 2) is a protein-coding gene. GO annotations related to this gene include acetate-CoA ligase activity and AMP binding. An important paralog of this gene is C10orf129.

UniProtKB/Swiss-Prot: ACSA_HUMAN, Q9NR19
Function: Activates acetate so that it can be used for lipid synthesis or for energy generation

Gene Wiki entry for ACSS2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NT_011362.11  NC_018931.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ACSS2 gene promoter:
         c-Fos   AP-1   Lmo2   C/EBPalpha   ATF6   c-Ets-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ACSS2 promoter sequence
   Search Chromatin IP Primers for ACSS2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ACSS2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q11.22   Ensembl cytogenetic band:  20q11.22   HGNC cytogenetic band: 20q11.22

ACSS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ACSS2 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P033459:  view genomic region     (about GC identifiers)

Start:
33,459,949 bp from pter      End:
33,515,769 bp from pter
Size:
55,821 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ACSA_HUMAN, Q9NR19 (See protein sequence)
Recommended Name: Acetyl-coenzyme A synthetase, cytoplasmic  
Size: 701 amino acids; 78580 Da
Subunit: Monomer
Secondary accessions: A6NE90 Q5QPH2 Q5QPH3 Q8N238 Q96EL0 Q9NQP7 Q9UJ15
Alternative splicing: 2 isoforms:  Q9NR19-1   Q9NR19-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ACSS2: NX_Q9NR19

Explore proteomics data for ACSS2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys418
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for ACSS2 (Q9NR19) (see all 18)
     AEAAVVG  YGPLANG  VAEAAVV  SGKIMRR 


    See ACSS2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001070020.2  NP_001229322.1  NP_061147.1  

    ENSEMBL proteins: 
     ENSP00000417783   ENSP00000418152   ENSP00000420105   ENSP00000353804   ENSP00000419167  
     ENSP00000418608   ENSP00000418812   ENSP00000419925   ENSP00000418362   ENSP00000420351  
     ENSP00000253382   ENSP00000337190  
    Reactome Protein details: Q9NR19

    ACSS2 Human Recombinant Protein Products:

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    Novus Biologicals ACSS2 Proteins
    Novus Biologicals ACSS2 Lysates
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    Cloud-Clone Corp. Proteins for ACSS2

     
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    antibodies-online proteins for ACSS2 (6 products) 

     
    antibodies-online peptides for ACSS2

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    ACSS2 Assay Products:

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    Cloud-Clone Corp. ELISAs for ACSS2
    Cloud-Clone Corp. CLIAs for ACSS2
    Search eBioscience for ELISAs for ACSS2 
    antibodies-online kits for ACSS2 (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ACS: Acyl-CoA synthetase family

    4 InterPro protein domains:
     IPR025110 AMP-bd_C
     IPR020845 AMP-binding_CS
     IPR011904 Ac_CoA_lig
     IPR000873 AMP-dep_Synth/Lig

    Graphical View of Domain Structure for InterPro Entry Q9NR19

    ProtoNet protein and cluster: Q9NR19

    1 Blocks protein domain: IPB000873 AMP-binding signature

    UniProtKB/Swiss-Prot: ACSA_HUMAN, Q9NR19
    Similarity: Belongs to the ATP-dependent AMP-binding enzyme family


    Find genes that share domains with ACSS2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ACSA_HUMAN, Q9NR19
    Function: Activates acetate so that it can be used for lipid synthesis or for energy generation
    Catalytic activity: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA

         Enzyme Numbers (IUBMB): EC 6.2.1.11 2 EC 6.2.12

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0003987acetate-CoA ligase activity IDA10843999
    GO:0005524ATP binding IEA--
    GO:0016208AMP binding IC10843999
         
    Find genes that share ontologies with ACSS2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ACSS2:
     Increased number of cells in m 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ACSS2

    miRNA
    Products:
        
    miRTarBase miRNAs that target ACSS2:
    hsa-mir-335-5p (MIRT018274)

    Block miRNA regulation of human, mouse, rat ACSS2 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate ACSS2:
    hsa-miR-3685 hsa-miR-485-5p hsa-miR-328 hsa-miR-631 hsa-miR-155* hsa-miR-452* hsa-miR-3661
    SwitchGear 3'UTR luciferase reporter plasmidACSS2 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat ACSS2

    Gene Editing
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ACSS2 (NM_018677)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACSS2

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACSS2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ACSA_HUMAN, Q9NR19: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus4
    mitochondrion2
    peroxisome2
    chloroplast1
    extracellular1
    plasma membrane1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0043231intracellular membrane-bounded organelle IDA--

    Find genes that share ontologies with ACSS2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ACSS2 About   (see all 13)  
    See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    2ethanol degradation II
    ethanol degradation II0.57
    oxidative ethanol degradation III0.57
    ethanol degradation IV0.57
    acetate conversion to acetyl-CoA0.00
    3Cytochrome P450 - arranged by substrate type
    Phase 1 - Functionalization of compounds0.75
    Ethanol oxidation0.00
    4Biological oxidations
    Biological oxidations0.56
    5Glycolysis and gluconeogenesis short map
    Glycolysis / Gluconeogenesis0.46


    Find genes that share SuperPaths with ACSS2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for ACSS2
        Glucose / Energy Metabolism

    Selected BioSystems Pathways for ACSS2 (see all 8)
        oxidative ethanol degradation III
    ethanol degradation IV
    ethanol degradation II
    acetate conversion to acetyl-CoA
    Fatty Acid Beta Oxidation

    1 Reactome Pathway for ACSS2
        Ethanol oxidation


    5 Kegg Pathways  (Kegg details for ACSS2):
        Glycolysis / Gluconeogenesis
    Pyruvate metabolism
    Propanoate metabolism
    Metabolic pathways
    Carbon metabolism

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ACSS2
    Interactions:

        Search GeneGlobe Interaction Network for ACSS2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ACSS2 (Q9NR191, 3 ENSP000003538044) via UniProtKB, MINT, STRING, and/or I2D (see all 57)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UPF1Q929001, 3, ENSP000002628034EBI-372879,EBI-373471 I2D: score=2 STRING: ENSP00000262803
    VAMP7P518093I2D: score=2 
    ACADMENSP000004096124STRING: ENSP00000409612
    ACAT1ENSP000002658384STRING: ENSP00000265838
    ACAT2ENSP000003560154STRING: ENSP00000356015
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006069ethanol oxidation TAS--
    GO:0006085acetyl-CoA biosynthetic process ----
    GO:0006805xenobiotic metabolic process TAS--
    GO:0008152metabolic process ----
    GO:0008610lipid biosynthetic process IMP10843999

    Find genes that share ontologies with ACSS2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ACSS2 (ACSA)

    Selected HMDB Compounds for ACSS2 (see all 11)    About this table
    CompoundSynonyms CAS #PubMed Ids
    Acetic acidAcetate (see all 12)64-19-7--
    Acetyl adenylate5'-O-[acetoxy(hydroxy)phosphoryl]adenosine (see all 5)13015-87-7--
    Acetyl-CoAS-Acetyl coenzyme A (see all 13)72-89-9--
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Coenzyme AAcetoacetyl coenzyme A sodium salt (see all 21)85-61-0--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Propinol adenylatePropionyladenylate ----
    Propionic acidAdofeed (see all 23)79-09-4--
    Propionyl-CoAPropionyl-CoA (see all 8)317-66-8--

    2 DrugBank Compounds for ACSS2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Adenosine monophosphate5'-Adenosine monophosphate (see all 15)61-19-8targetproduct of17303131 17497934 17350930 16981708
    Adenosine triphosphate5'-ATP (see all 8)56-65-5target--17139284 17016423 12493915 14704009

    Selected Novoseek inferred chemical compound relationships for ACSS2 gene (see all 23)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    acetyl-coa 92.2 96 10859180 (5), 12722651 (4), 20232292 (4), 10681568 (4) (see all 49)
    acyl-coa 79.1 11 20105319 (1), 1684180 (1), 1455165 (1), 18375835 (1) (see all 10)
    pyruvate 59.6 4 11171136 (1), 10859180 (1), 14665385 (1)
    propionate 54 3 12618394 (1), 12700259 (1)
    fatty acid 53 5 1684180 (1), 10859180 (1), 18375835 (1), 10843999 (1) (see all 5)
    atp 51.5 7 12493915 (1), 12627952 (1), 11007993 (1), 1390767 (1) (see all 7)
    pyrophosphate 50.9 2 8854380 (1), 8954523 (1)
    nad+ 47.9 1 15023335 (1)
    lysine 42.5 3 12493915 (1), 15019790 (1)
    acetaldehyde 40.5 3 12722651 (2), 11171136 (1)



    Find genes that share compounds with ACSS2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ACSS2 gene (4 alternative transcripts): 
    NM_001076552.2  NM_001242393.1  NM_018677.3  NM_139274.1  

    Unigene Cluster for ACSS2:

    Acyl-CoA synthetase short-chain family member 2
    Hs.517034  [show with all ESTs]
    Unigene Representative Sequence: NM_001076552
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 25):
    ENST00000490046 ENST00000481971 ENST00000497927 ENST00000488172 ENST00000481284(uc002xbc.2)
    ENST00000475459 ENST00000461051 ENST00000360596(uc010zum.1 uc010gey.2 uc002xbd.2 uc002xbe.2)
    ENST00000484354 ENST00000480274 ENST00000493805 ENST00000473172 ENST00000477932
    ENST00000480978 ENST00000467019 ENST00000253382 ENST00000476922 ENST00000464399

    miRNA
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    7 qRT-PCR Assays for microRNAs that regulate ACSS2:
    hsa-miR-3685 hsa-miR-485-5p hsa-miR-328 hsa-miR-631 hsa-miR-155* hsa-miR-452* hsa-miR-3661
    SwitchGear 3'UTR luciferase reporter plasmidACSS2 3' UTR sequence
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    GenScript: all cDNA clones in your preferred vector (see all 2): ACSS2 (NM_018677)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACSS2
    Primer
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      QuantiFast Probe-based Assays in human, mouse, rat ACSS2

    Additional mRNA sequence: 

    AF263614.1 AK000162.1 AK000188.1 AK022608.1 AK025990.1 AK092281.1 AK098026.1 AK293634.1 
    AL359946.1 BC010141.2 BC012172.1 BC073846.1 BC098422.1 CR749716.1 

    Selected DOTS entries (see all 28):

    DT.117903  DT.92435403  DT.95144125  DT.100027348  DT.100027349  DT.100823046  DT.92435401  DT.120806401 
    DT.120806345  DT.100674175  DT.100823050  DT.120806369  DT.91727585  DT.100669576  DT.100823049  DT.120806362 
    DT.120806376  DT.120806398  DT.120806443  DT.87078860  DT.92435405  DT.92435406  DT.92435409  DT.95148030 

    Selected AceView cDNA sequences (see all 270):

    BI909907 BU521906 BM928542 AA564041 BX103848 BC073846 AA877172 AF263614 
    AI942249 BM824237 BI711796 CB161732 BE048767 BM557823 BM826260 BM684262 
    AI827164 BI768876 BM984830 AI480383 CB306420 BU069804 BM830892 BU689470 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ACSS2 (see all 12)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a ·
    SP1:                                      -     -                             -                                               -                             -   
    SP2:        -     -     -     -           -     -                             -                       -                       -                             -   
    SP3:                                      -     -                             -                       -                       -                             -   
    SP4:                                      -     -     -     -     -     -     -     -     -     -     -                       -                             -   
    SP5:                                      -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -   

    ExUns: 19b · 19c ^ 20 ^ 21 ^ 22 ^ 23a · 23b · 23c
    SP1:                                                
    SP2:                                                
    SP3:                                                
    SP4:                                                
    SP5:                    -                           


    ECgene alternative splicing isoforms for ACSS2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ACSS2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACTTGCCCT
    ACSS2 Expression
    About this image


    ACSS2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     NULL (Uncategorized)
             Definitive endoderm-like cells
     
     Yolk Sac (Extraembryonic Tissues)
             Definitive Hematopoietic Stem Cells Definitive Yolk Sac
     
     Blood (Cardiovascular System)
             Definitive Hematopoietic Stem Cells Definitive Yolk Sac
     
     Colon (Gastrointestinal Tract)
    ACSS2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ACSS2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.517034
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ACSS2 gene from Selected species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Acss21 , 5 acyl-CoA synthetase short-chain family member 21, 5 90.58(n)1
    93.58(a)1
      2 (77.26 cM)5
    605251  NM_019811.31  NP_062785.21 
     1555179485 
    chicken
    (Gallus gallus)
    Aves ACSS21 acyl-CoA synthetase short-chain family member 2 74.55(n)
    79.25(a)
      419158  XM_417342.4  XP_417342.4 
    lizard
    (Anolis carolinensis)
    Reptilia ACSS26
    acyl-CoA synthetase short-chain family member 2
    78(a)
    1 ↔ 1
    4(135304943-135364816)
    African clawed frog
    (Xenopus laevis)
    Amphibia AW641033.12   -- 76.66(n)    AW641033.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.146482 Transcribed sequence with weak similarity to protein more 78.75(n)    BI897382.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta AcCoAS1 Acetyl Coenzyme A synthase 62.96(n)
    64.18(a)
      40348  NM_001014599.2  NP_001014599.2 
    worm
    (Caenorhabditis elegans)
    Secernentea acs-191 acs-19 55.67(n)
    54.14(a)
      175500  NM_001026034.3  NP_001021205.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ACS16
    Acetyl-coA synthetase isoform which, along with Ac...
    42(a)
    1 → many
    I(42881-45022) YAL054C
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ACS1 ACS 58.24(n)
    59.84(a)
      833655  NM_001036897.2  NP_001031974.2 
    rice
    (Oryza sativa)
    Liliopsida Os.85652 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 76.58(n)    AK066073.1 


    ENSEMBL Gene Tree for ACSS2 (if available)
    TreeFam Gene Tree for ACSS2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ACSS2 gene
    C10orf1292  ACSM52  ACSM32  ACSM2A2  ACSM12  ACSM42  ACSM2B2  ACSS12  
    ACSF22  
    7 SIMAP similar genes for ACSS2 using alignment to 15 protein entries:     ACSA_HUMAN (see all proteins):
    DKFZp762G026    FLJ00013    DKFZp666B209    ACSS3    DKFZp666G0810    ACSS1
    A-923A4.2

    Find genes that share paralogs with ACSS2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ACSS2 (see all 1150)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2007560551,2
    C--30245780(+) CCCCCA/CAAAAA 3 -- int10--------
    rs345782381,2
    C--30254338(+) AAAAAAA/-GCCTG 3 -- int11Minor allele frequency- -:0.50NA 2
    rs114250791,2
    C--30268228(+) CTTTTC/-CCCCA 3 -- int11Minor allele frequency- -:0.50CSA 2
    rs1431685211,2
    C--30285707(+) GGCAA-/GTG   
       TGTGT
    GTGTG
    3 -- int10--------
    rs1406019561,2
    C--30290809(+) TTTTT-/TTGTTGTT 3 -- int10--------
    rs2013493631,2
    C--30290829(+) TGTTGG/TTTGTT 3 -- int10--------
    rs20644531,2
    C,F,O,A,H--33464139(+) GTGCGC/TGTAGA 1 -- us2k116Minor allele frequency- T:0.35NA EA WA CSA 738
    rs1824828261,2
    --33464171(+) CAGGGG/TCGAGG 1 -- us2k10--------
    rs1870572001,2
    --33464227(+) CAGCTC/TAGGGA 1 -- us2k10--------
    rs1165088091,2
    F--33464238(+) CCAAAC/TCCCTT 1 -- us2k11Minor allele frequency- T:0.01WA 118

    HapMap Linkage Disequilibrium report for ACSS2 (33459949 - 33515769 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for ACSS2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2722357CNV Deletion23290073
    esv2520076CNV Deletion19546169
    esv2671024CNV Deletion23128226
    esv2743305CNV Deletion23290073
    esv271518CNV Insertion20981092
    nsv833962CNV Loss17160897
    dgv95n6CNV Loss16902084
    nsv912860CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605832    OMIM disorders: --


    Find genes that share disorders with ACSS2           About GenesLikeMe

    Genetic Association Database (GAD): ACSS2
    Human Genome Epidemiology (HuGE) Navigator: ACSS2 (5 documents)

    Export disorders for ACSS2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ACSS2 gene, integrated from 10 sources (see all 92):
    (articles sorted by number of sources associating them with ACSS2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular characterization of human acetyl-CoA synthetase, an enzyme regulated by sterol regulatory element-binding proteins. (PubMed id 10843999)1, 2, 3, 9 Luong A.... Goldstein J.L. (J. Biol. Chem. 2000)
    2. Identification of type 2 diabetes-associated combination of SNPs using support vector machine. (PubMed id 20416077)1, 4 Ban H.J....Park K.J. (BMC Genet. 2010)
    3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    4. Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. (PubMed id 18660489)1, 4 Lu Y....Boer J.M. (J. Lipid Res. 2008)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    8. Biochemical and crystallographic analysis of substrate binding and conformational changes in acetyl-CoA synthetase. (PubMed id 17497934)7, 9 Reger A.S....Gulick A.M. (Biochemistry 2007)
    9. The importance of acetyl coenzyme A synthetase for 11C-acetate uptake and cell survival in hepatocellular carcinoma. (PubMed id 19617323)1, 9 Yun M....Lee J.D. (J. Nucl. Med. 2009)
    10. Sir2-dependent activation of acetyl-CoA synthetase by deacetylation of active lysine. (PubMed id 12493915)7, 9 Starai V.J....Escalante-Semerena J.C. (Science 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55902 HGNC: 15814 AceView: ACAS2 Ensembl:ENSG00000131069 euGenes: HUgn55902
    ECgene: ACSS2 Kegg: 55902 H-InvDB: ACSS2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ACSS2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ACSS2 gene:
    Search GeneIP for patents involving ACSS2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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