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Aliases for ACSS1 Gene

Aliases for ACSS1 Gene

  • Acyl-CoA Synthetase Short-Chain Family Member 1 2 3 4
  • Acetate--CoA Ligase 2 3 4
  • EC 6.2.1.1 4 63
  • ACAS2L 3 4
  • ACECS1 3 6
  • Acetyl-Coenzyme A Synthetase 2-Like, Mitochondrial 3
  • Acetyl-Coenzyme A Synthetase 2 (AMP Forming)-Like 2
  • Acetyl-CoA Synthetase 2 4
  • KIAA1846 4
  • EC 6.2.1 63
  • AceCS2L 3
  • AceCS2 4

External Ids for ACSS1 Gene

Previous HGNC Symbols for ACSS1 Gene

  • ACAS2L

Previous GeneCards Identifiers for ACSS1 Gene

  • GC20M024935

Summaries for ACSS1 Gene

Entrez Gene Summary for ACSS1 Gene

  • This gene encodes a mitochondrial acetyl-CoA synthetase enzyme. A similar protein in mice plays an important role in the tricarboxylic acid cycle by catalyzing the conversion of acetate to acetyl CoA. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

GeneCards Summary for ACSS1 Gene

ACSS1 (Acyl-CoA Synthetase Short-Chain Family Member 1) is a Protein Coding gene. Among its related pathways are Regulation of Cholesterol Biosynthesis by SREBP (SREBF) and Metabolism. GO annotations related to this gene include AMP binding and acetate-CoA ligase activity. An important paralog of this gene is ACSM2B.

UniProtKB/Swiss-Prot for ACSS1 Gene

  • Important for maintaining normal body temperature during fasting and for energy homeostasis. Essential for energy expenditure under ketogenic conditions (By similarity). Converts acetate to acetyl-CoA so that it can be used for oxidation through the tricarboxylic cycle to produce ATP and CO(2).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACSS1 Gene

Genomics for ACSS1 Gene

Regulatory Elements for ACSS1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ACSS1 Gene

Start:
25,005,147 bp from pter
End:
25,058,980 bp from pter
Size:
53,834 bases
Orientation:
Minus strand

Genomic View for ACSS1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ACSS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACSS1 Gene

Proteins for ACSS1 Gene

  • Protein details for ACSS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NUB1-ACS2L_HUMAN
    Recommended name:
    Acetyl-coenzyme A synthetase 2-like, mitochondrial
    Protein Accession:
    Q9NUB1
    Secondary Accessions:
    • B3KXL2
    • B4DJZ3
    • D3DW48
    • F5H6F4
    • F8W7Y1
    • Q5TF42
    • Q8IV99
    • Q8N234
    • Q96JI1
    • Q96JX6
    • Q9NU28

    Protein attributes for ACSS1 Gene

    Size:
    689 amino acids
    Molecular mass:
    74857 Da
    Quaternary structure:
    • Interacts with SIRT3.
    SequenceCaution:
    • Sequence=BAB55390.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC03853.1; Type=Frameshift; Positions=250; Evidence={ECO:0000305}; Sequence=BAC03853.1; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ACSS1 Gene

    Alternative splice isoforms for ACSS1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ACSS1 Gene

Proteomics data for ACSS1 Gene at MOPED

Selected DME Specific Peptides for ACSS1 Gene

Post-translational modifications for ACSS1 Gene

  • Reversibly acetylated on Lys-642. The acetyl-CoA synthase activity is inhibited by acetylation and activated by deacetylation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ACSS1 Gene

Domains for ACSS1 Gene

Gene Families for ACSS1 Gene

HGNC:
  • ACS :Acyl-CoA synthetase family

Protein Domains for ACSS1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NUB1

UniProtKB/Swiss-Prot:

ACS2L_HUMAN :
  • Q9NUB1
Family:
  • Belongs to the ATP-dependent AMP-binding enzyme family.
genes like me logo Genes that share domains with ACSS1: view

Function for ACSS1 Gene

Molecular function for ACSS1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA
UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by acetylation at Lys-642 and activated by deacetylation.
UniProtKB/Swiss-Prot Function: Important for maintaining normal body temperature during fasting and for energy homeostasis. Essential for energy expenditure under ketogenic conditions (By similarity). Converts acetate to acetyl-CoA so that it can be used for oxidation through the tricarboxylic cycle to produce ATP and CO(2).

Enzyme Numbers (IUBMB) for ACSS1 Gene

Gene Ontology (GO) - Molecular Function for ACSS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0003987 acetate-CoA ligase activity IDA 16788062
GO:0005515 protein binding IPI 16788062
GO:0005524 ATP binding IEA --
GO:0016208 AMP binding IEA --
genes like me logo Genes that share ontologies with ACSS1: view
genes like me logo Genes that share phenotypes with ACSS1: view

Animal Models for ACSS1 Gene

MGI Knock Outs for ACSS1:

Animal Model Products

CRISPR Products

miRNA for ACSS1 Gene

No data available for Transcription Factor Targeting and HOMER Transcription for ACSS1 Gene

Localization for ACSS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACSS1 Gene

Mitochondrion matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ACSS1 Gene COMPARTMENTS Subcellular localization image for ACSS1 gene
Compartment Confidence
mitochondrion 5
cytosol 2
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ACSS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005759 mitochondrial matrix TAS --
genes like me logo Genes that share ontologies with ACSS1: view

Pathways for ACSS1 Gene

genes like me logo Genes that share pathways with ACSS1: view

Gene Ontology (GO) - Biological Process for ACSS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006069 ethanol oxidation TAS --
GO:0006085 acetyl-CoA biosynthetic process IDA 16788062
GO:0006805 xenobiotic metabolic process TAS --
GO:0008152 metabolic process --
GO:0019413 acetate biosynthetic process IEA --
genes like me logo Genes that share ontologies with ACSS1: view

Compounds for ACSS1 Gene

(12) HMDB Compounds for ACSS1 Gene

Compound Synonyms Cas Number PubMed IDs
Acetic acid
  • Acetate
64-19-7
Acetyl adenylate
  • 5'-O-[acetoxy(hydroxy)phosphoryl]adenosine
13015-87-7
Acetyl-CoA
  • S-Acetyl coenzyme A
72-89-9
Adenosine monophosphate
  • 5'-AMP
61-19-8
Adenosine tetraphosphate
  • Adenosine 5'-tetraphosphate
58337-43-2

(2) Drugbank Compounds for ACSS1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Adenosine monophosphate
  • 5'-Adenosine monophosphate
61-19-8 target product of
Adenosine triphosphate
  • 5'-ATP
56-65-5 target
genes like me logo Genes that share compounds with ACSS1: view

Transcripts for ACSS1 Gene

Unigene Clusters for ACSS1 Gene

Acyl-CoA synthetase short-chain family member 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ACSS1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ACSS1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c ^ 14a ·
SP1: - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - -
SP4: - - - - - - - - -
SP5: - -
SP6: - - -
SP7:
SP8: -
SP9: -
SP10: -
SP11: - - -
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:

ExUns: 14b · 14c · 14d ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b · 19c ^ 20a · 20b · 20c · 20d · 20e ^ 21 ^ 22
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - - - - - - - - - -
SP5:
SP6:
SP7: - - - - - - - - - - - -
SP8:
SP9:
SP10:
SP11:
SP12: - - - - - -
SP13: - - - -
SP14: - - -
SP15:
SP16: - - -
SP17: -
SP18:

Relevant External Links for ACSS1 Gene

GeneLoc Exon Structure for
ACSS1
ECgene alternative splicing isoforms for
ACSS1

Expression for ACSS1 Gene

mRNA expression in normal human tissues for ACSS1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ACSS1 Gene

SOURCE GeneReport for Unigene cluster for ACSS1 Gene Hs.529353

genes like me logo Genes that share expressions with ACSS1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ACSS1 Gene

Orthologs for ACSS1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ACSS1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ACSS1 35
  • 99.42 (n)
  • 99.42 (a)
ACSS1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ACSS1 35
  • 84.28 (n)
  • 85.71 (a)
ACSS1 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ACSS1 35
  • 86.73 (n)
  • 89.74 (a)
ACSS1 36
  • 69 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Acss1 35
  • 84.26 (n)
  • 87.68 (a)
Acss1 16
Acss1 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ACSS1 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ACSS1 36
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Acss1 35
  • 84.41 (n)
  • 86.66 (a)
chicken
(Gallus gallus)
Aves ACSS1 35
  • 74.84 (n)
  • 79.39 (a)
ACSS1 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ACSS1 36
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia acss1 35
  • 69.84 (n)
  • 76.86 (a)
zebrafish
(Danio rerio)
Actinopterygii acss1 35
  • 68.81 (n)
  • 74 (a)
acss1 36
  • 68 (a)
OneToOne
sbcb395 35
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL148C 35
  • 52.89 (n)
  • 47.97 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ACS1 36
  • 42 (a)
OneToMany
ACS2 35
  • 50.68 (n)
  • 48.78 (a)
ACS2 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D17336g 35
  • 51.82 (n)
  • 48.94 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06836 35
  • 57.37 (n)
  • 49.43 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC191.02c 35
  • 52.92 (n)
  • 47.99 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 55 (a)
OneToMany
CSA.5469 36
  • 41 (a)
OneToMany
Species with no ortholog for ACSS1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ACSS1 Gene

ENSEMBL:
Gene Tree for ACSS1 (if available)
TreeFam:
Gene Tree for ACSS1 (if available)

Paralogs for ACSS1 Gene

Paralogs for ACSS1 Gene

Selected SIMAP similar genes for ACSS1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ACSS1: view

Variants for ACSS1 Gene

Sequence variations from dbSNP and Humsavar for ACSS1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs3646 -- 25,058,203(+) CCTTC(C/G)GCCAC upstream-variant-2KB
rs761720 -- 25,045,430(+) GTCAC(A/G)GTGGG intron-variant
rs910526 -- 25,046,257(+) TTAGA(A/G)ACAGA intron-variant
rs910527 -- 25,046,442(+) TCCCA(C/T)GGGCA intron-variant
rs1007881 -- 25,033,749(+) GCTCA(A/G)CTTGG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ACSS1 Gene

Variant ID Type Subtype PubMed ID
nsv522873 CNV Gain 19592680
nsv912826 CNV Loss 21882294

Relevant External Links for ACSS1 Gene

HapMap Linkage Disequilibrium report
ACSS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACSS1 Gene

Disorders for ACSS1 Gene

Relevant External Links for ACSS1

Genetic Association Database (GAD)
ACSS1
Human Genome Epidemiology (HuGE) Navigator
ACSS1
genes like me logo Genes that share disorders with ACSS1: view

No data available for UniProtKB/Swiss-Prot for ACSS1 Gene

Publications for ACSS1 Gene

  1. Crystal structures of human SIRT3 displaying substrate-induced conformational changes. (PMID: 19535340) Jin L. … Perni R.B. (J. Biol. Chem. 2009) 3 4 23
  2. Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2. (PMID: 16788062) Schwer B. … Verdin E. (Proc. Natl. Acad. Sci. U.S.A. 2006) 3 4 23
  3. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T. … Ohara O. (DNA Res. 2001) 3 4
  4. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for ACSS1 Gene

Sources for ACSS1 Gene

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