Aliases for ACSS1 Gene
External Ids for ACSS1 Gene
Previous HGNC Symbols for ACSS1 Gene
Previous GeneCards Identifiers for ACSS1 Gene
This gene encodes a mitochondrial acetyl-CoA synthetase enzyme. A similar protein in mice plays an important role in the tricarboxylic acid cycle by catalyzing the conversion of acetate to acetyl CoA. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
GeneCards Summary for ACSS1 Gene
ACSS1 (Acyl-CoA Synthetase Short-Chain Family Member 1) is a Protein Coding gene. Among its related pathways are Regulation of cholesterol biosynthesis by SREBP (SREBF) and Signaling events mediated by HDAC Class III. GO annotations related to this gene include AMP binding and acetate-CoA ligase activity. An important paralog of this gene is ACSS2.
UniProtKB/Swiss-Prot for ACSS1 Gene
Important for maintaining normal body temperature during fasting and for energy homeostasis. Essential for energy expenditure under ketogenic conditions (By similarity). Converts acetate to acetyl-CoA so that it can be used for oxidation through the tricarboxylic cycle to produce ATP and CO(2).