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Aliases for ACSM6 Gene

Aliases for ACSM6 Gene

  • Acyl-CoA Synthetase Medium-Chain Family Member 6 2 3 4 5
  • EC 4 63
  • C10orf129 3 4
  • Chromosome 10 Open Reading Frame 129 2
  • AMP-Binding Enzyme 3
  • BA310E22.3 3
  • EC 6.2.1 63

External Ids for ACSM6 Gene

Previous HGNC Symbols for ACSM6 Gene

  • C10orf129

Summaries for ACSM6 Gene

GeneCards Summary for ACSM6 Gene

ACSM6 (Acyl-CoA Synthetase Medium-Chain Family Member 6) is a Protein Coding gene. Among its related pathways are Butanoate metabolism and gamma-linolenate biosynthesis. GO annotations related to this gene include GTP binding and butyrate-CoA ligase activity. An important paralog of this gene is ACSM2B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACSM6 Gene

Genomics for ACSM6 Gene

Regulatory Elements for ACSM6 Gene

Enhancers for ACSM6 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ACSM6 on UCSC Golden Path with GeneCards custom track

Genomic Location for ACSM6 Gene

95,194,200 bp from pter
95,228,929 bp from pter
34,730 bases
Plus strand

Genomic View for ACSM6 Gene

Genes around ACSM6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACSM6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACSM6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACSM6 Gene

Proteins for ACSM6 Gene

  • Protein details for ACSM6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Acyl-coenzyme A synthetase ACSM6, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • A4FU95
    • A4IF38
    • Q5VZX2
    • Q6ZTX1

    Protein attributes for ACSM6 Gene

    480 amino acids
    Molecular mass:
    53585 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Monomer.
    • Sequence=AAI04211.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI04212.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI12989.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAH72344.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ACSM6 Gene


neXtProt entry for ACSM6 Gene

Proteomics data for ACSM6 Gene at MOPED

Selected DME Specific Peptides for ACSM6 Gene

Post-translational modifications for ACSM6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ACSM6 Gene

Domains & Families for ACSM6 Gene

Protein Domains for ACSM6 Gene


Suggested Antigen Peptide Sequences for ACSM6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ATP-dependent AMP-binding enzyme family.
  • Belongs to the ATP-dependent AMP-binding enzyme family.
genes like me logo Genes that share domains with ACSM6: view

No data available for Gene Families for ACSM6 Gene

Function for ACSM6 Gene

Molecular function for ACSM6 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a carboxylate + CoA = AMP + diphosphate + an acyl-CoA.

Enzyme Numbers (IUBMB) for ACSM6 Gene

Phenotypes for ACSM6 Gene

genes like me logo Genes that share phenotypes with ACSM6: view

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ACSM6 Gene

Localization for ACSM6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACSM6 Gene


No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for ACSM6 Gene

Pathways & Interactions for ACSM6 Gene

genes like me logo Genes that share pathways with ACSM6: view

Pathways by source for ACSM6 Gene

2 KEGG pathways for ACSM6 Gene

Interacting Proteins for ACSM6 Gene

Gene Ontology (GO) - Biological Process for ACSM6 Gene


No data available for SIGNOR curated interactions for ACSM6 Gene

Drugs & Compounds for ACSM6 Gene

(11) Drugs for ACSM6 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0
butyric acid Experimental Pharma Full agonist, Agonist 348
Diphosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0

(34) Additional Compounds for ACSM6 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • (E)-S-2-decenoate
  • (E)-S-2-decenoate CoA
  • (E)-S-2-decenoate Coenzyme A
  • (E)-S-2-decenoic acid
  • 2-trans-Decenoyl-CoA
  • (2E)-Dodec-2-enoyl-CoA
  • (2E)-Dodec-2-enoyl-Coenzyme A
  • 2-trans-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
  • (2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-Coenzyme A
  • trans-2-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-Coenzyme A
  • (E)-S-2-octenoate
  • (E)-S-2-octenoate CoA
  • (E)-S-2-octenoate Coenzyme A
  • (E)-S-2-octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
  • (2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
  • Trans-tetra-dec-2-enoyl-CoA
  • Trans-tetra-dec-2-enoyl-CoA.
  • Trans-tetra-dec-2-enoyl-Coenzyme A
genes like me logo Genes that share compounds with ACSM6: view

Transcripts for ACSM6 Gene

mRNA/cDNA for ACSM6 Gene

(2) REFSEQ mRNAs :
(7) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for ACSM6 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11
SP2: - -
SP3: -

Relevant External Links for ACSM6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ACSM6 Gene

mRNA expression in normal human tissues for ACSM6 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ACSM6 Gene

genes like me logo Genes that share expression patterns with ACSM6: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ACSM6 Gene

Orthologs for ACSM6 Gene

This gene was present in the common ancestor of animals.

Orthologs for ACSM6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C10H10orf129 35
  • 99.24 (n)
  • 98.12 (a)
C10orf129 36
  • 93 (a)
(Ornithorhynchus anatinus)
Mammalia C10orf129 36
  • 61 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 37 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11391 36
  • 15 (a)
(Caenorhabditis elegans)
Secernentea acs-16 36
  • 13 (a)
Species with no ortholog for ACSM6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for ACSM6 Gene

Gene Tree for ACSM6 (if available)
Gene Tree for ACSM6 (if available)

Paralogs for ACSM6 Gene

Paralogs for ACSM6 Gene

(7) SIMAP similar genes for ACSM6 Gene using alignment to 1 proteins: Pseudogenes for ACSM6 Gene

genes like me logo Genes that share paralogs with ACSM6: view

Variants for ACSM6 Gene

Sequence variations from dbSNP and Humsavar for ACSM6 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs7090248 - 95,210,718(+) CACCA(A/G)GGGTA reference, missense
rs591157 - 95,194,541(+) ATTTG(A/G)AGCCT reference, missense, utr-variant-5-prime
rs11188225 - 95,194,603(+) CCAGG(A/T)GCCTA reference, missense, utr-variant-5-prime
rs16872 -- 95,210,604(-) GGTTC(A/G/T)CTGAT intron-variant
rs1681759 -- 95,197,512(+) ctgga(C/T)gtgca intron-variant

Variation tolerance for ACSM6 Gene

Gene Damage Index Score: 5.81; 73.75% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for ACSM6 Gene

Disorders for ACSM6 Gene

Relevant External Links for ACSM6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ACSM6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ACSM6 Gene

Publications for ACSM6 Gene

  1. An integrated clinico-metabolomic model improves prediction of death in sepsis. (PMID: 23884467) Langley R.J. … Kingsmore S.F. (Sci Transl Med 2013) 2 3 67
  2. High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy. (PMID: 24270810) Hasson S.A. … Youle R.J. (Nature 2013) 3
  3. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for ACSM6 Gene

Sources for ACSM6 Gene