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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ACSM5 Gene

protein-coding GIFtS: 51
GCID: GC16P020420

acyl-CoA synthetase medium-chain family member 5

Explore 4 diseases affiliated with
ACSM5 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Acyl-CoA Synthetase Medium-Chain Family Member 5¹ ² ³
EC 6.2.1.2³ ⁸
FLJ20581¹
Acyl-Coenzyme A Synthetase ACSM5, Mitochondrial²
MACS3³
EC 6.2.1⁸

External Ids:	HGNC: 26060¹	Entrez Gene: 54988²	Ensembl: ENSG00000183549⁷	OMIM: 614361⁵	UniProtKB: Q6NUN0³

Export aliases for ACSM5 gene to outside databases

Previous GC identifers: GC16P020329 GC16P018957

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ACSM5_HUMAN, Q6NUN0

Function: Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids

from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4-unsaturated acids (in vitro) (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000016.9 NC_018927.1 NT_010393.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ACSM5 gene promoter:
HEN1 PPAR-alpha NF-1 AP-1 NRSF form 1 Sox9 STAT3 AP-4 NRSF form 2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ACSM5 promoter sequence

Search SABiosciences Chromatin IP Primers for ACSM5

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ACSM5

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p12.3 Ensembl cytogenetic band: 16p12.3 HGNC cytogenetic band: 16p12.3

ACSM5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ACSM5 gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16P020420: view genomic region (about GC identifiers)

Start:	20,420,856 bp from pter	End:	20,452,658 bp from pter
Size:	31,803 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ACSM5_HUMAN, Q6NUN0 (See protein sequence)

Recommended Name: Acyl-coenzyme A synthetase ACSM5, mitochondrial precursor

Size: 579 amino acids; 64760 Da

Cofactor: Magnesium or manganese (By similarity)

Subcellular location: Mitochondrion matrix (By similarity)

Sequence caution: Sequence=BAA91273.1; Type=Frameshift; Positions=560;

Secondary accessions: Q96AV1 Q96CX8 Q9NWV3

Alternative splicing: 2 isoforms: Q6NUN0-1 Q6NUN0-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ACSM5: NX_Q6NUN0

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q6NUN0

4/12 DME Specific Peptides for ACSM5 (Q6NUN0) (see all 12)

GTTGAPK

VACMRTG

APYKYPR

GNVLPPG

ACSM5 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_060358.2

ENSEMBL proteins:

ENSP00000460112 ENSP00000327916 ENSP00000461752

Human Recombinant Protein Products for ACSM5:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	GenScript Custom Purified and Recombinant Proteins Services for ACSM5
	Novus Biologicals ACSM5 Protein Novus Biologicals ACSM5 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for ACSM5

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005759	mitochondrial matrix	IEA	--

ACSM5 for ontologies About GeneDecksing

ACSM5 Antibody Products:

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	Novus Biologicals ACSM5 Antibodies
	Search for Antibodies for ACSM5 at Abcam
	Uscn Antibodies for ACSM5
	Search ThermoFisher Antibodies for ACSM5

Assay Products for ACSM5:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for ACSM5
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for ACSM5

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ACSM5 for domains About GeneDecksing

3 InterPro domains/families:

IPR000873 AMP-dep_Synth/Lig

IPR020845 AMP-binding_CS

IPR025110 DUF4009

Graphical View of Domain Structure for InterPro Entry Q6NUN0

ProtoNet protein and cluster: Q6NUN0

1 Blocks protein family: IPB000873 AMP-binding signature

UniProtKB/Swiss-Prot: ACSM5_HUMAN, Q6NUN0

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: ACSM5_HUMAN, Q6NUN0

Function: Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids

from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4-unsaturated acids (in vitro) (By similarity)

Catalytic activity: ATP + a carboxylate + CoA = AMP + diphosphate + an acyl-CoA

Enzyme Numbers (IUBMB): EC 6.2.1.2¹ ² EC 6.2.1²

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003824	catalytic activity	--	--
GO:0005524	ATP binding	IEA	--
GO:0005525	GTP binding	IEA	--
GO:0046872	metal ion binding	IEA	--
GO:0047760	butyrate-CoA ligase activity	IEA	--

ACSM5 for ontologies About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ACSM5

miRNA Products:		OriGene 3'-UTR Clone: ACSM5 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ACSM5
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate ACSM5:
		hsa-miR-4303 hsa-miR-610 hsa-miR-544
		SwitchGear 3'UTR luciferase reporter plasmid: ACSM5 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ACSM5 (see all 4) OriGene shRNA RFP: ACSM5 OriGene siRNA: ACSM5
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ACSM5
		Sirion Biotech Custom design and validation of potent shRNA sequences against ACSM5

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for ACSM5
			Sirion Biotech Customized adenovirus for overexpression of ACSM5 Sirion Biotech Customized adenovirus for potent knockdown of ACSM5

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ACSM5 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ACSM5 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ACSM5 (NM_017888)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ACSM5
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACSM5

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ACSM5
		Search LifeMap BioReagents cell lines for ACSM5
		Sirion Biotech Customized stable knockdown cell line services for ACSM5 Sirion Biotech Customized inducible knockdown cell line services for ACSM5 Sirion Biotech Customized stable overexpressing cell line services for ACSM5 Sirion Biotech Customized inducible overexpressing cell line services for ACSM5

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACSM5

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

eicosapentaenoate biosynthesis II (metazoa)

eicosapentaenoate biosynthesis II (metazoa)

1.00

gamma-linolenate biosynthesis II (animals)

0.69

Valproic Acid Pathway, Pharmacokinetics

Valproic Acid Pathway, Pharmacokinetics

1.00

Metabolism

Metabolic pathways

0.38

Ketone body metabolism

Butanoate metabolism

0.17

Pathway sources
See GeneCards unified pathways
Show all pathways

2 BioSystems Pathways for ACSM5

	gamma-linolenate biosynthesis II (animals)
	eicosapentaenoate biosynthesis II (metazoa)

1 PharmGKB Pathway for ACSM5

Valproic Acid Pathway, Pharmacokinetics

2 Kegg Pathways (Kegg details for ACSM5):

	Butanoate metabolism
	Metabolic pathways

ACSM5 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ACSM5

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

2 Interacting proteins for ACSM5 (ENSP00000327916⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ACADS	ENSP00000242592⁴	STRING: ENSP00000242592
EP300	ENSP00000263253⁴	STRING: ENSP00000263253

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006631	fatty acid metabolic process	IEA	--

ACSM5 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ACSM5

10/40 HMDB Compounds for ACSM5 (see all 40) About this table

Compound	Synonyms	CAS #	PubMed Ids
(2E)-Decenoyl-CoA	(E)-S-2-decenoate Coenzyme A (see all 15)	10018-95-8	--
(2E)-Dodecenoyl-CoA	2-trans-Dodecenoyl-Coenzyme A (see all 4)	1066-12-2	--
(2E)-Hexadecenoyl-CoA	trans-2-Hexadecenoyl-CoA (see all 4)	4460-95-1	--
(2E)-Octenoyl-CoA	(E)-S-2-octenoate Coenzyme A (see all 16)	10018-94-7	--
(2E)-Tetradecenoyl-CoA	(2E)-Tetradecenoyl-Coenzyme A (see all 8)	38795-33-4	--
2-Methylbutyryl-CoA	2-methylbutanoyl-CoA (see all 11)	6712-02-3	--
2-Methylhexanoyl-CoA	2-Methylhexanoyl-CoEnzyme A (see all 5)	--	--
3Z-dodecenoyl-CoA	S-[2-[3-[[(2R)-4-[[[(2R,3R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (Z)-dodec-3-enethioate (see all 4)	2152-91-2	--
Acetyl-CoA	S-Acetyl coenzyme A (see all 13)	72-89-9	--
Acrylyl-CoA	Acryloyl coenzyme A (see all 14)	5776-58-9	--

Search CenterWatch for drugs/clinical trials and news about ACSM5

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ACSM5 gene:

NM_017888.2

Unigene Cluster for ACSM5:

Acyl-CoA synthetase medium-chain family member 5

Hs.659606 [show with all ESTs]

Unigene Representative Sequence: BC068516

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000575584(uc002dhd.1) ENST00000331849(uc002dhe.3) ENST00000575070

ENST00000570305 ENST00000574748 ENST00000573920 ENST00000577024

miRNA Products:		OriGene 3'-UTR Clone: ACSM5 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ACSM5
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate ACSM5:
		hsa-miR-4303 hsa-miR-610 hsa-miR-544
		SwitchGear 3'UTR luciferase reporter plasmid: ACSM5 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ACSM5 (see all 4) OriGene shRNA RFP: ACSM5 OriGene siRNA: ACSM5
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ACSM5
		Sirion Biotech Custom design and validation of potent shRNA sequences against ACSM5

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ACSM5 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ACSM5 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ACSM5 (NM_017888)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ACSM5
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ACSM5

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ACSM5 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ACSM5
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ACSM5
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ACSM5

Additional cDNA sequence:

AK000588.1 BC013753.1 BC016703.1 BC068516.1

7 DOTS entries:

DT.403739 DT.92429576 DT.95367603 DT.95256685 DT.92429572 DT.92429571 DT.99954204

24/49 AceView cDNA sequences (see all 49):

AA873330 BC068516 BX116869 AI436700 AV687871 NM_017888 BC013753 AK000588

BQ650371 BI459920 BI763186 AI791417 BG249440 AV652688 BI549397 BI546870

CB158491 AI733019 AV654888 AV652689 BC016703 AV699287 AV652696 BG719476

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ACSM5 (see all 6) About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	^	3	^	4a	·	4b	^	5a	·	5b	·	5c	·	5d	^	6	^	7	^	8	^	9a	·	9b	^	10	^	11	^	12	^	13	^	14
SP1:							-						-		-		-
SP2:
SP3:																							-
SP4:																									-
SP5:							-

ECgene alternative splicing isoforms for ACSM5

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ACSM5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGGAGCATCA

About this image
See ACSM5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ACSM5

SOURCE GeneReport for Unigene cluster: Hs.659606

UniProtKB/Swiss-Prot: ACSM5_HUMAN, Q6NUN0

Tissue specificity: Detected in kidney and liver

SABiosciences Expression via Pathway-Focused PCR Array including ACSM5:

Fatty Acid Metabolism in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ACSM5 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ACSM5
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ACSM5
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ACSM5

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACSM5

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the last universal common ancestor (LUCA).

Orthologs for ACSM5 gene from 5/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	ACSM5¹	acyl-CoA synthetase medium-chain family member 5	65.13(n) 62.65(a)		426992 XM_424596.3 XP_424596.3
zebrafish (Danio rerio)	Actinopterygii	acsm3⁶	acyl-CoA synthetase medium-chain family member 3	54(a)	1 → many	2(44787051-44808224)
thale cress (Arabidopsis thaliana)	eudicotyledons	AT3G48990⁶	AMP-dependent synthetase and ligase-like protein	23(a)	possible ortholog	3(18158747-18161379)
rice (Oryza sativa)	Liliopsida	--	AMP-binding domain containing protein, expressed	24(a)	possible ortholog	4(34723331-34725551)
E. coli (Escherichia coli)	Gamma proteobacteria	aas⁶	fused 2-acylglycerophospho-ethanolamine acyl trans...	13(a)	possible ortholog	Chromosome(2971877-2974036)

ENSEMBL Gene Tree for ACSM5 (if available)
TreeFam Gene Tree for ACSM5 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ACSM5 gene

C10orf129² ACSM3² ACSS2² ACSM2A² ACSM1² ACSM4² ACSS3² ACSM2B²

ACSF2² ACSS1²

7 SIMAP similar genes for ACSM5 using alignment to 2 protein entries: ACSM5_HUMAN (see all proteins):

ACSM4 ACSM3 ACSM2A ACSM1 ACSM2B ACSM6

A-923A4.2

ACSM5 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for ACSM5
PGOHUM00000248751

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs60050831^1,2	C	--	20418887(+)	`ATTCTC/TGCTTA`	1	--	us2k¹		5		WA CSA NA EA	362
rs184021651^1,2		--	20419066(+)	`GGATGA/TCTATC`	1	--	us2k¹		0	--	--	--	--
rs7185747^1,2	C,F,H	--	20419098(+)	`cacctA/Caaata`	1	--	us2k¹		5		NS EA WA	536
rs149387810^1,2		--	20419200(+)	`TTGCAG/TGCCTG`	1	--	us2k¹		0	--	--	--	--
rs186838667^1,2		--	20419312(+)	`GACCGA/GTATGG`	1	--	us2k¹		0	--	--	--	--
rs192289163^1,2		--	20419435(+)	`TGTCTC/TCCAGG`	1	--	us2k¹		0	--	--	--	--
rs184304929^1,2		--	20419473(+)	`CACTGA/CAACCT`	1	--	us2k¹		0	--	--	--	--
rs190742478^1,2		--	20419603(+)	`TAGTAC/GAGACA`	1	--	us2k¹		0	--	--	--	--
rs146331143^1,2		--	20419624(+)	`GTGTTA/GGTCAG`	1	--	us2k¹		0	--	--	--	--
rs139541940^1,2		--	20419639(+)	`GTCTCA/GATCTT`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ACSM5 (20420856 - 20452658 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ACSM5
1 CNV: 3113

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ACSM5

DNA2.0 Custom Variant and Variant Library Synthesis for ACSM5

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ACSM5 for disorders           About GeneDecksing

OMIM gene information: 614361    OMIM disorders: --

4 diseases for ACSM5:    About MalaCards

kidney disease hepatocellular carcinoma hypertension carcinoma

Human Genome Epidemiology (HuGE) Navigator: ACSM5 (1 document)

Export disorders for ACSM5 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ACSM5 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ACSM5)

Utopia: connect your pdf to the dynamic
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Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome. (PubMed id 17762044)^{1, 3} Watkins P.A.... Pevsner J. (2007)
Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)¹ Hendrickson S.L....O'Brien S.J. (2010)
New loci associated with kidney function and chronic kidney disease. (PubMed id 20383146)¹ KAPttgen A....Fox C.S. (2010)
The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)² Martin J.... Pennacchio L.A. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)² Ota T.... Sugano S. (2004)
An acyl-CoA synthetase gene family in chromosome 16p12 may contribute to multiple risk factors. (PubMed id 12654705)² Iwai N....Iwanaga Y. (2003)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver. (PubMed id 11752456)¹ Xu X.R.... Han Z.G. (2001)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 54988	HGNC: 26060	AceView: FLJ20581	Ensembl:ENSG00000183549	euGenes: HUgn54988
ECgene: ACSM5	Kegg: 54988	H-InvDB: ACSM5

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for ACSM5	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ACSM5 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for ACSM5 gene:
Search GeneIP for patents involving ACSM5

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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ACSM5 Gene

acyl-CoA synthetase medium-chain family member 5

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ACSM5 Gene

acyl-CoA synthetase medium-chain family member 5

Aliasesfor ACSM5 gene

Summariesfor ACSM5 gene

Genomic Viewsfor ACSM5 gene

Proteinsfor ACSM5 gene

Protein Domains /Familiesfor ACSM5 gene

Functionfor ACSM5 gene

Pathways & Interactionsfor ACSM5 gene

Drugs & Compoundsfor ACSM5 gene

Transcriptsfor ACSM5 gene

Expression for ACSM5 gene

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Disorders / Diseasesfor ACSM5 gene

Publicationsfor ACSM5 gene

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Genome Databases showing ACSM5 gene

Other Databases showing ACSM5 gene

Specialized Databases showing ACSM5 gene

Intellectual Propertyfor ACSM5 gene

Productsfor ACSM5 gene

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Aliases
for ACSM5 gene

Summaries
for ACSM5 gene

Genomic Views
for ACSM5 gene

Proteins
for ACSM5 gene

Protein Domains /
Families
for ACSM5 gene

Function
for ACSM5 gene

Pathways & Interactions
for ACSM5 gene

Drugs & Compounds
for ACSM5 gene

Transcripts
for ACSM5 gene

Expression
for ACSM5 gene

Orthologs
for ACSM5 gene

Paralogs
for ACSM5 gene

Genomic Variants
for ACSM5 gene

Disorders / Diseases
for ACSM5 gene

Publications
for ACSM5 gene

Intellectual Property
for ACSM5 gene

Products
for ACSM5 gene