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Aliases for ACSM4 Gene

Aliases for ACSM4 Gene

  • Acyl-CoA Synthetase Medium-Chain Family Member 4 2 3 4
  • EC 6.2.1.2 4 63
  • Similar To Olfactory Specific Medium-Chain Acyl CoA Synthetase 2
  • EC 6.2.1 63

External Ids for ACSM4 Gene

Previous GeneCards Identifiers for ACSM4 Gene

  • GC12P007349
  • GC12P007456

Summaries for ACSM4 Gene

GeneCards Summary for ACSM4 Gene

ACSM4 (Acyl-CoA Synthetase Medium-Chain Family Member 4) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include butyrate-CoA ligase activity and fatty-acyl-CoA synthase activity. An important paralog of this gene is ACSM2B.

UniProtKB/Swiss-Prot for ACSM4 Gene

  • Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4-unsaturated acids (in vitro) (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACSM4 Gene

Genomics for ACSM4 Gene

Genomic Location for ACSM4 Gene

Start:
7,304,284 bp from pter
End:
7,328,724 bp from pter
Size:
24,441 bases
Orientation:
Plus strand

Genomic View for ACSM4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ACSM4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACSM4 Gene

Proteins for ACSM4 Gene

  • Protein details for ACSM4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0C7M7-ACSM4_HUMAN
    Recommended name:
    Acyl-coenzyme A synthetase ACSM4, mitochondrial
    Protein Accession:
    P0C7M7
    Secondary Accessions:
    • A8MTI6

    Protein attributes for ACSM4 Gene

    Size:
    580 amino acids
    Molecular mass:
    65703 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available

neXtProt entry for ACSM4 Gene

Proteomics data for ACSM4 Gene at MOPED

Post-translational modifications for ACSM4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ACSM4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for ACSM4 Gene

Gene Families for ACSM4 Gene

HGNC:
  • ACS :Acyl-CoA synthetase family

Protein Domains for ACSM4 Gene

Suggested Antigen Peptide Sequences for ACSM4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P0C7M7

UniProtKB/Swiss-Prot:

ACSM4_HUMAN :
  • P0C7M7
Family:
  • Belongs to the ATP-dependent AMP-binding enzyme family.
genes like me logo Genes that share domains with ACSM4: view

Function for ACSM4 Gene

Molecular function for ACSM4 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a carboxylate + CoA = AMP + diphosphate + an acyl-CoA
UniProtKB/Swiss-Prot Function: Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4-unsaturated acids (in vitro) (By similarity).

Enzyme Numbers (IUBMB) for ACSM4 Gene

Gene Ontology (GO) - Molecular Function for ACSM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004321 fatty-acyl-CoA synthase activity IEA --
GO:0005524 ATP binding IEA --
GO:0046872 metal ion binding IEA --
GO:0047760 butyrate-CoA ligase activity IEA --
genes like me logo Genes that share ontologies with ACSM4: view
genes like me logo Genes that share phenotypes with ACSM4: view

Animal Model Products

CRISPR Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ACSM4 Gene

Localization for ACSM4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACSM4 Gene

Mitochondrion matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ACSM4 Gene COMPARTMENTS Subcellular localization image for ACSM4 gene
Compartment Confidence
mitochondrion 2

Gene Ontology (GO) - Cellular Components for ACSM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005759 mitochondrial matrix IEA --
genes like me logo Genes that share ontologies with ACSM4: view

Pathways for ACSM4 Gene

genes like me logo Genes that share pathways with ACSM4: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for ACSM4 Gene

Gene Ontology (GO) - Biological Process for ACSM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006631 fatty acid metabolic process IEA --
GO:0006637 acyl-CoA metabolic process IEA --
GO:0008152 metabolic process --
genes like me logo Genes that share ontologies with ACSM4: view

Compounds for ACSM4 Gene

(40) HMDB Compounds for ACSM4 Gene

Compound Synonyms Cas Number PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate Coenzyme A
10018-95-8
(2E)-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-CoA
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate Coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
38795-33-4
genes like me logo Genes that share compounds with ACSM4: view

Transcripts for ACSM4 Gene

mRNA/cDNA for ACSM4 Gene

(0) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ACSM4 Gene

Acyl-CoA synthetase medium-chain family member 4:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ACSM4

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ACSM4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ACSM4 Gene

No ASD Table

Relevant External Links for ACSM4 Gene

GeneLoc Exon Structure for
ACSM4
ECgene alternative splicing isoforms for
ACSM4

Expression for ACSM4 Gene

mRNA expression in normal human tissues for ACSM4 Gene

mRNA differential expression in normal tissues according to GTEx for ACSM4 Gene

This gene is overexpressed in Testis (19.1).

SOURCE GeneReport for Unigene cluster for ACSM4 Gene Hs.450804

genes like me logo Genes that share expressions with ACSM4: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein expression and mRNA Expression by UniProt/SwissProt for ACSM4 Gene

Orthologs for ACSM4 Gene

This gene was present in the common ancestor of animals.

Orthologs for ACSM4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ACSM4 35
  • 99.37 (n)
  • 98.97 (a)
ACSM4 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ACSM4 35
  • 89.95 (n)
  • 91.68 (a)
ACSM4 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ACSM4 35
  • 88.63 (n)
  • 87.61 (a)
ACSM4 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Acsm4 35
  • 86.48 (n)
  • 86.83 (a)
Acsm4 16
Acsm4 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ACSM4 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 78 (a)
OneToMany
-- 36
  • 53 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Acsm4 35
  • 85.9 (n)
  • 86.31 (a)
chicken
(Gallus gallus)
Aves ACSM4 35
  • 65.62 (n)
  • 61.98 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 61 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG11659 36
  • 19 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea acs-16 36
  • 18 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 26 (a)
ManyToMany
Species with no ortholog for ACSM4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for ACSM4 Gene

ENSEMBL:
Gene Tree for ACSM4 (if available)
TreeFam:
Gene Tree for ACSM4 (if available)

Paralogs for ACSM4 Gene

Paralogs for ACSM4 Gene

Selected SIMAP similar genes for ACSM4 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for ACSM4 Gene

genes like me logo Genes that share paralogs with ACSM4: view

Variants for ACSM4 Gene

Sequence variations from dbSNP and Humsavar for ACSM4 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs4132642 -- 7,325,017(-) gctaa(A/G)gtgta intron-variant
rs4883253 -- 7,320,113(+) GGGAC(A/G)TAGTG intron-variant
rs4883254 -- 7,324,967(+) CTCCA(G/T)TTGAT intron-variant
rs6487811 -- 7,311,275(+) CCTCT(C/T)CTGCT intron-variant
rs6487838 -- 7,313,239(+) ACAAC(A/G)GATAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ACSM4 Gene

Variant ID Type Subtype PubMed ID
nsv832325 CNV Gain+Loss 17160897

Relevant External Links for ACSM4 Gene

HapMap Linkage Disequilibrium report
ACSM4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACSM4 Gene

Disorders for ACSM4 Gene

Relevant External Links for ACSM4

Genetic Association Database (GAD)
ACSM4
Human Genome Epidemiology (HuGE) Navigator
ACSM4
genes like me logo Genes that share disorders with ACSM4: view

No data available for UniProtKB/Swiss-Prot for ACSM4 Gene

Publications for ACSM4 Gene

  1. Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome. (PMID: 17762044) Watkins P.A. … Pevsner J. (J. Lipid Res. 2007) 2 3 4
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48
  3. ACSM4 polymorphisms are associated with rapid AIDS progression in HIV-infected patients. (PMID: 23982661) GuzmA!n-Fulgencio M. … Resino S. (J. Acquir. Immune Defic. Syndr. 2014) 3
  4. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer S.E. … Gibbs R.A. (Nature 2006) 4

Products for ACSM4 Gene

Sources for ACSM4 Gene

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