Aliases for ACSM4 Gene
Aliases for ACSM4 Gene
External Ids for ACSM4 Gene
- HGNC: 32016
- Entrez Gene: 341392
- Ensembl: ENSG00000215009
- OMIM: 614360
- UniProtKB: P0C7M7
Previous GeneCards Identifiers for ACSM4 Gene
- GC12P007349
- GC12P007456
Summaries for ACSM4 Gene
GeneCards Summary for ACSM4 Gene
ACSM4 (Acyl-CoA Synthetase Medium-Chain Family Member 4) is a Protein Coding gene. Among its related pathways are Conjugation of carboxylic acids and fatty acid beta-oxidation (peroxisome). GO annotations related to this gene include butyrate-CoA ligase activity and fatty-acyl-CoA synthase activity. An important paralog of this gene is ACSM5.
UniProtKB/Swiss-Prot for ACSM4 Gene
-
Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4-unsaturated acids (in vitro) (By similarity).
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACSM4 Gene
Genomics for ACSM4 Gene
Regulatory Elements for ACSM4 Gene
- Transcription factor binding sites by QIAGEN in the ACSM4 gene promoter:
Regulatory Element Products
Genomic Location for ACSM4 Gene
- Chromosome:
- 12
- Start:
- 7,304,284 bp from pter
- End:
- 7,328,724 bp from pter
- Size:
- 24,441 bases
- Orientation:
- Plus strand
Genomic View for ACSM4 Gene
- Cytogenetic band:
-
- 12p13.31 by Ensembl
- 12p13.31 by Entrez Gene
- 12p13.31 by HGNC
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ACSM4 Gene
Proteins for ACSM4 Gene
-
Protein details for ACSM4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P0C7M7-ACSM4_HUMAN
- Recommended name:
- Acyl-coenzyme A synthetase ACSM4, mitochondrial
- Protein Accession:
- P0C7M7
- A8MTI6
Protein attributes for ACSM4 Gene
- Size:
- 580 amino acids
- Molecular mass:
- 65703 Da
- Cofactor:
- Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
- Quaternary structure:
- No Data Available
Selected DME Specific Peptides for ACSM4 Gene
- P0C7M7:
-
- LPRIPEWWL
- SGYRIGP
- IKPGSMGK
- LPKTITGKI
- TAPYKYPRK
- PTVYRMLVQ
- GNVLPPG
- ESAVVSSPD
- RGEVVKAF
- LRHCLTGGE
- SRKAANVL
- APYKYPR
Post-translational modifications for ACSM4 Gene
Other Protein References for ACSM4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for ACSM4
- Novus Biologicals Antibodies for ACSM4
- Invitrogen Antibodies for ACSM4
- GeneTex ACSM4 antibody for ACSM4
Protein Products
-
OriGene Purified Proteins for ACSM4
- Search Origene for MassSpec and Protein Over-expression Lysates for ACSM4
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- Novus Biologicals proteins for ACSM4
- Search GeneTex for Proteins for ACSM4
Assay Products
Domains & Families for ACSM4 Gene
Gene Families for ACSM4 Gene
Protein Domains for ACSM4 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for ACSM4 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P0C7M7- Family:
-
- Belongs to the ATP-dependent AMP-binding enzyme family.
Function for ACSM4 Gene
Molecular function for ACSM4 Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a carboxylate + CoA = AMP + diphosphate + an acyl-CoA.
- UniProtKB/Swiss-Prot Function:
- Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4-unsaturated acids (in vitro) (By similarity).
Enzyme Numbers (IUBMB) for ACSM4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003824 | catalytic activity | IEA | -- |
| GO:0003996 | acyl-CoA ligase activity | IBA | -- |
| GO:0004321 | fatty-acyl-CoA synthase activity | IBA,IEA | -- |
| GO:0005524 | ATP binding | IEA | -- |
| GO:0015645 | fatty acid ligase activity | IBA | -- |
Phenotypes for ACSM4 Gene
- MGI mutant phenotypes for ACSM4:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for ACSM4:
Animal Model Products
-
Taconic Biosciences Mouse Models for ACSM4
- Cyagen custom Knockout/knockin (KOKI) mouse models for ACSM4
-
-
ViGene Biosciences lentiviral particle packaged cDNA for ACSM4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ACSM4 gene
- Search ViGene Biosciences for ACSM4
CRISPR Products
-
OriGene CRISPR knockouts for ACSM4
-
Santa Cruz Biotechnology (SCBT) CRISPR for ACSM4
- GenScript: Design CRISPR guide RNA sequences for ACSM4
miRNA Products
- Search ViGene Biosciences for ACSM4
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for ACSM4
- Browse OriGene Inhibitory RNA Products For ACSM4
-
ViGene Biosciences ready-to-package AAV shRNAs for ACSM4 gene
Clone Products
-
OriGene ORF clones in human for ACSM4
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- VectorBuilder custom plasmid, inducible vectors for ACSM4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ACSM4
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for ACSM4
-
ViGene Biosciences adenoviral particle packaged cDNA for ACSM4 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for ACSM4 gene
-
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Flow Cytometry Products
No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ACSM4 Gene
Localization for ACSM4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ACSM4 Gene
- Mitochondrion matrix.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005739 | mitochondrion | IEA | -- |
| GO:0005759 | mitochondrial matrix | IBA,IEA | -- |
Pathways & Interactions for ACSM4 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Conjugation of carboxylic acids | ||
| 2 | Metabolism |
.37
|
|
| 3 | Cytochrome P450 - arranged by substrate type | ||
| 4 | fatty acid beta-oxidation (peroxisome) | ||
| 5 | Butanoate metabolism | ||
Pathways by source for ACSM4 Gene
2 BioSystems pathways for ACSM4 Gene
6 Reactome pathways for ACSM4 Gene
1 PharmGKB pathway for ACSM4 Gene
2 KEGG pathways for ACSM4 Gene
Interacting Proteins for ACSM4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006629 | lipid metabolic process | IEA | -- |
| GO:0006631 | fatty acid metabolic process | IEA | -- |
| GO:0006633 | fatty acid biosynthetic process | IBA | -- |
| GO:0006637 | acyl-CoA metabolic process | IBA,IEA | -- |
| GO:0008152 | metabolic process | IEA | -- |
No data available for SIGNOR curated interactions for ACSM4 Gene
Drugs & Compounds for ACSM4 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| (2E)-Decenoyl-CoA |
|
10018-95-8 |
|
|||
| (2E)-Dodecenoyl-CoA |
|
1066-12-2 |
|
|||
| (2E)-Hexadecenoyl-CoA |
|
4460-95-1 |
|
|||
| (2E)-Octenoyl-CoA |
|
10018-94-7 |
|
|||
| (2E)-Tetradecenoyl-CoA |
|
38795-33-4 |
|
Transcripts for ACSM4 Gene
mRNA/cDNA for ACSM4 Gene
- (1) REFSEQ mRNAs :
- (0) Additional mRNA sequences :
- -
- (1) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ACSM4 Gene
- Acyl-CoA synthetase medium-chain family member 4:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for ACSM4
-
Santa Cruz Biotechnology (SCBT) CRISPR for ACSM4
- GenScript: Design CRISPR guide RNA sequences for ACSM4
miRNA Products
- Search ViGene Biosciences for ACSM4
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for ACSM4
- Browse OriGene Inhibitory RNA Products For ACSM4
-
ViGene Biosciences ready-to-package AAV shRNAs for ACSM4 gene
Clone Products
-
OriGene ORF clones in human for ACSM4
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- VectorBuilder custom plasmid, inducible vectors for ACSM4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ACSM4
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for ACSM4 Gene
mRNA differential expression in normal tissues according to GTEx for ACSM4 Gene
NURSA nuclear receptor signaling pathways regulating expression of ACSM4 Gene:
ACSM4SOURCE GeneReport for Unigene cluster for ACSM4 Gene:
Hs.450804Primer Products
-
OriGene qPCR primer pairs for ACSM4
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ACSM4 Gene
Orthologs for ACSM4 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ACSM4 34 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | ACSM4 35 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | ACSM4 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | ACSM4 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Acsm4 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Acsm4 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
OneToMany | |
| -- 35 |
|
OneToMany | |||
| chicken (Gallus gallus) |
Aves | ACSM4 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | -- 35 |
|
ManyToMany | |
| fruit fly (Drosophila melanogaster) |
Insecta | CG11659 35 |
|
ManyToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | acs-16 35 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
ManyToMany |
- Species where no ortholog for ACSM4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- zebrafish (Danio rerio)
Paralogs for ACSM4 Gene
(7) SIMAP similar genes for ACSM4 Gene using alignment to 1 proteins:
Pseudogenes.org Pseudogenes for ACSM4 Gene
Variants for ACSM4 Gene
| SNP ID | Clin | Chr 12 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000017737 | -- | 7,309,187(+) | GTTTA(A/G)GATGA | intron-variant | |
| rs1000182068 | -- | 7,311,681(+) | CTTTT(-/TTG)TTGTT | intron-variant | |
| rs1000232864 | -- | 7,312,092(+) | ACTGT(A/G)TGGCC | intron-variant | |
| rs1000234356 | -- | 7,311,973(+) | GGCAT(C/G)AGCCA | intron-variant | |
| rs1000480216 | -- | 7,306,329(+) | TGCTC(A/G)GGGAA | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1349n100 | CNV | gain | 25217958 |
| dgv448e212 | CNV | gain | 25503493 |
| esv3628416 | CNV | loss | 21293372 |
| esv3628417 | CNV | loss | 21293372 |
| nsv832325 | CNV | gain+loss | 17160897 |
Relevant External Links for ACSM4 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ACSM4
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACSM4 Gene
Disorders for ACSM4 Gene
Relevant External Links for ACSM4
No disorders were found for ACSM4 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ACSM4 Gene
Publications for ACSM4 Gene
- Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome. (PMID: 17762044) Watkins P.A. … Pevsner J. (J. Lipid Res. 2007) 2 3 4 64
- Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
- ACSM4 polymorphisms are associated with rapid AIDS progression in HIV-infected patients. (PMID: 23982661) GuzmA!n-Fulgencio M. … Resino S. (J. Acquir. Immune Defic. Syndr. 2014) 3 64
- A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene. (PMID: 19490893) Luo J. … Elledge S.J. (Cell 2009) 3 64
- The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer S.E. … Gibbs R.A. (Nature 2006) 4 64
Products for ACSM4 Gene
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- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
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- Custom Antibody ServicesOriGene Antibodies for ACSM4
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- Browse OriGene Inhibitory RNA Products For ACSM4
- OriGene qPCR primer pairs for ACSM4
- OriGene CRISPR knockouts for ACSM4
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- GenScript: Design CRISPR guide RNA sequences for ACSM4
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- CloneReady with Over 120,000 Genes
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- Novus Biologicals Antibodies for ACSM4
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- Taconic Biosciences Mouse Models for ACSM4
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- Humanized Mice
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- Horizon Cell Lines for ACSM4
- Cyagen custom Knockout/knockin (KOKI) mouse models for ACSM4
- VectorBuilder custom plasmid, inducible vectors for ACSM4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ACSM4
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for ACSM4 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer




