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Aliases for ACSM4 Gene

Aliases for ACSM4 Gene

  • Acyl-CoA Synthetase Medium-Chain Family Member 4 2 3 4 5
  • EC 4 63
  • Similar To Olfactory Specific Medium-Chain Acyl CoA Synthetase 2
  • EC 6.2.1 63

External Ids for ACSM4 Gene

Previous GeneCards Identifiers for ACSM4 Gene

  • GC12P007349
  • GC12P007456

Summaries for ACSM4 Gene

GeneCards Summary for ACSM4 Gene

ACSM4 (Acyl-CoA Synthetase Medium-Chain Family Member 4) is a Protein Coding gene. Among its related pathways are Phase II conjugation and Butanoate metabolism. GO annotations related to this gene include butyrate-CoA ligase activity and fatty-acyl-CoA synthase activity. An important paralog of this gene is ACSM2B.

UniProtKB/Swiss-Prot for ACSM4 Gene

  • Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4-unsaturated acids (in vitro) (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACSM4 Gene

Genomics for ACSM4 Gene

Regulatory Elements for ACSM4 Gene

Enhancers for ACSM4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ACSM4 on UCSC Golden Path with GeneCards custom track

Genomic Location for ACSM4 Gene

7,304,284 bp from pter
7,328,724 bp from pter
24,441 bases
Plus strand

Genomic View for ACSM4 Gene

Genes around ACSM4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACSM4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACSM4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACSM4 Gene

Proteins for ACSM4 Gene

  • Protein details for ACSM4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Acyl-coenzyme A synthetase ACSM4, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • A8MTI6

    Protein attributes for ACSM4 Gene

    580 amino acids
    Molecular mass:
    65703 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available

neXtProt entry for ACSM4 Gene

Proteomics data for ACSM4 Gene at MOPED

Post-translational modifications for ACSM4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ACSM4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for ACSM4 Gene

Gene Families for ACSM4 Gene

Protein Domains for ACSM4 Gene

Suggested Antigen Peptide Sequences for ACSM4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ATP-dependent AMP-binding enzyme family.
  • Belongs to the ATP-dependent AMP-binding enzyme family.
genes like me logo Genes that share domains with ACSM4: view

Function for ACSM4 Gene

Molecular function for ACSM4 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a carboxylate + CoA = AMP + diphosphate + an acyl-CoA.
UniProtKB/Swiss-Prot Function:
Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4-unsaturated acids (in vitro) (By similarity).

Enzyme Numbers (IUBMB) for ACSM4 Gene

genes like me logo Genes that share phenotypes with ACSM4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ACSM4

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ACSM4 Gene

Localization for ACSM4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACSM4 Gene

Mitochondrion matrix.

Subcellular locations from

Jensen Localization Image for ACSM4 Gene COMPARTMENTS Subcellular localization image for ACSM4 gene
Compartment Confidence
mitochondrion 4

No data available for Gene Ontology (GO) - Cellular Components for ACSM4 Gene

Pathways & Interactions for ACSM4 Gene

genes like me logo Genes that share pathways with ACSM4: view

Pathways by source for ACSM4 Gene

Interacting Proteins for ACSM4 Gene

Gene Ontology (GO) - Biological Process for ACSM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006631 fatty acid metabolic process IEA --
genes like me logo Genes that share ontologies with ACSM4: view

No data available for SIGNOR curated interactions for ACSM4 Gene

Drugs & Compounds for ACSM4 Gene

(11) Drugs for ACSM4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0
butyric acid Experimental Pharma Full agonist, Agonist 348
Diphosphate Experimental Pharma 0
Heptanoic acid Experimental Pharma 0

(33) Additional Compounds for ACSM4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • (E)-S-2-decenoate
  • (E)-S-2-decenoate CoA
  • (E)-S-2-decenoate Coenzyme A
  • (E)-S-2-decenoic acid
  • 2-trans-Decenoyl-CoA
  • (2E)-Dodec-2-enoyl-CoA
  • (2E)-Dodec-2-enoyl-Coenzyme A
  • 2-trans-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
  • (2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-Coenzyme A
  • trans-2-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-Coenzyme A
  • (E)-S-2-octenoate
  • (E)-S-2-octenoate CoA
  • (E)-S-2-octenoate Coenzyme A
  • (E)-S-2-octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
  • (2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
  • Trans-tetra-dec-2-enoyl-CoA
  • Trans-tetra-dec-2-enoyl-CoA.
  • Trans-tetra-dec-2-enoyl-Coenzyme A
genes like me logo Genes that share compounds with ACSM4: view

Transcripts for ACSM4 Gene

mRNA/cDNA for ACSM4 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ACSM4 Gene

Acyl-CoA synthetase medium-chain family member 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ACSM4 Gene

No ASD Table

Relevant External Links for ACSM4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ACSM4 Gene

mRNA expression in normal human tissues for ACSM4 Gene

mRNA differential expression in normal tissues according to GTEx for ACSM4 Gene

This gene is overexpressed in Testis (x19.1).

SOURCE GeneReport for Unigene cluster for ACSM4 Gene Hs.450804

genes like me logo Genes that share expression patterns with ACSM4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ACSM4 Gene

Orthologs for ACSM4 Gene

This gene was present in the common ancestor of animals.

Orthologs for ACSM4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ACSM4 35
  • 89.95 (n)
  • 91.68 (a)
ACSM4 36
  • 91 (a)
(Canis familiaris)
Mammalia ACSM4 35
  • 88.63 (n)
  • 87.61 (a)
ACSM4 36
  • 87 (a)
(Mus musculus)
Mammalia Acsm4 35
  • 86.48 (n)
  • 86.83 (a)
Acsm4 16
Acsm4 36
  • 86 (a)
(Pan troglodytes)
Mammalia ACSM4 35
  • 99.37 (n)
  • 98.97 (a)
ACSM4 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Acsm4 35
  • 85.9 (n)
  • 86.31 (a)
(Monodelphis domestica)
Mammalia ACSM4 36
  • 90 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 78 (a)
-- 36
  • 53 (a)
(Gallus gallus)
Aves ACSM4 35
  • 65.62 (n)
  • 61.98 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 61 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11659 36
  • 19 (a)
(Caenorhabditis elegans)
Secernentea acs-16 36
  • 18 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 26 (a)
Species with no ortholog for ACSM4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for ACSM4 Gene

Gene Tree for ACSM4 (if available)
Gene Tree for ACSM4 (if available)

Paralogs for ACSM4 Gene

Paralogs for ACSM4 Gene

(7) SIMAP similar genes for ACSM4 Gene using alignment to 1 proteins: Pseudogenes for ACSM4 Gene

genes like me logo Genes that share paralogs with ACSM4: view

Variants for ACSM4 Gene

Sequence variations from dbSNP and Humsavar for ACSM4 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
VAR_061010 -
rs7137120 -- 7,303,001(+) TACAA(A/G)GTAGA upstream-variant-2KB
rs7137372 -- 7,322,406(+) CAACT(A/C)TGTCT intron-variant
rs7137603 -- 7,303,403(+) TTAGC(A/T)AGGCA upstream-variant-2KB
rs7294678 -- 7,313,345(+) GGAGT(A/G)TCATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ACSM4 Gene

Variant ID Type Subtype PubMed ID
nsv832325 CNV Gain+Loss 17160897

Variation tolerance for ACSM4 Gene

Residual Variation Intolerance Score: 85.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.27; 76.41% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ACSM4 Gene

Disorders for ACSM4 Gene

Relevant External Links for ACSM4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ACSM4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ACSM4 Gene

Publications for ACSM4 Gene

  1. Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome. (PMID: 17762044) Watkins P.A. … Pevsner J. (J. Lipid Res. 2007) 2 3 4 67
  2. ACSM4 polymorphisms are associated with rapid AIDS progression in HIV-infected patients. (PMID: 23982661) GuzmA!n-Fulgencio M. … Resino S. (J. Acquir. Immune Defic. Syndr. 2014) 3
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3
  4. A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene. (PMID: 19490893) Luo J. … Elledge S.J. (Cell 2009) 3

Products for ACSM4 Gene

Sources for ACSM4 Gene