Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ACSM3 Gene

Aliases for ACSM3 Gene

  • Acyl-CoA Synthetase Medium-Chain Family Member 3 2 3 4
  • SAH 3 4 6
  • SA (Rat Hypertension-Associated) Homolog 2 3
  • Middle-Chain Acyl-CoA Synthetase 3 3 4
  • Butyryl-Coenzyme A Synthetase 3 3 4
  • Butyrate--CoA Ligase 3 3 4
  • Protein SA Homolog 3 4
  • EC 6.2.1.2 4 63
  • Acyl-Coenzyme A Synthetase ACSM3, Mitochondrial 3
  • SA Hypertension-Associated Homolog (Rat) 2
  • SA Hypertension-Associated Homolog 3
  • EC 6.2.1 63
  • SA 3

External Ids for ACSM3 Gene

Previous Symbols for ACSM3 Gene

  • SAH

Summaries for ACSM3 Gene

GeneCards Summary for ACSM3 Gene

ACSM3 (Acyl-CoA Synthetase Medium-Chain Family Member 3) is a Protein Coding gene. Diseases associated with ACSM3 include hypertension, essential. Among its related pathways are Metabolism and stearate biosynthesis I (animals). GO annotations related to this gene include butyrate-CoA ligase activity and fatty acid ligase activity. An important paralog of this gene is ACSM2B.

UniProtKB/Swiss-Prot for ACSM3 Gene

  • Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4-unsaturated acids (in vitro) (By similarity).

Gene Wiki entry for ACSM3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACSM3 Gene

Genomics for ACSM3 Gene

Genomic Location for ACSM3 Gene

Start:
20,610,243 bp from pter
End:
20,797,581 bp from pter
Size:
187,339 bases
Orientation:
Plus strand

Genomic View for ACSM3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ACSM3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACSM3 Gene

Regulatory Elements for ACSM3 Gene

Proteins for ACSM3 Gene

  • Protein details for ACSM3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q53FZ2-ACSM3_HUMAN
    Recommended name:
    Acyl-coenzyme A synthetase ACSM3, mitochondrial
    Protein Accession:
    Q53FZ2
    Secondary Accessions:
    • O60363
    • Q13732
    • Q15425
    • Q7KYM6
    • Q9BUA2

    Protein attributes for ACSM3 Gene

    Size:
    586 amino acids
    Molecular mass:
    66153 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC31667.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA03853.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA56369.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ACSM3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ACSM3 Gene

Proteomics data for ACSM3 Gene at MOPED

Post-translational modifications for ACSM3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains for ACSM3 Gene

Gene Families for ACSM3 Gene

HGNC:
  • ACS :Acyl-CoA synthetase family

Protein Domains for ACSM3 Gene

Suggested Antigen Peptide Sequences for ACSM3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q53FZ2

UniProtKB/Swiss-Prot:

ACSM3_HUMAN
Family:
  • Belongs to the ATP-dependent AMP-binding enzyme family.:
    • Q53FZ2
genes like me logo Genes that share domains with ACSM3: view

Function for ACSM3 Gene

Molecular function for ACSM3 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a carboxylate + CoA = AMP + diphosphate + an acyl-CoA
UniProtKB/Swiss-Prot Function: Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4-unsaturated acids (in vitro) (By similarity).

Enzyme Numbers (IUBMB) for ACSM3 Gene

Gene Ontology (GO) - Molecular Function for ACSM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003824 catalytic activity --
GO:0005524 ATP binding IEA --
GO:0015645 fatty acid ligase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ACSM3: view

Phenotypes for ACSM3 Gene

MGI mutant phenotypes for ACSM3:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with ACSM3: view

Animal Models for ACSM3 Gene

MGI Knock Outs for ACSM3:

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for ACSM3 Gene

Localization for ACSM3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACSM3 Gene

Mitochondrion matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ACSM3 Gene COMPARTMENTS Subcellular localization image for ACSM3 gene
Compartment Confidence
mitochondrion 2
cytosol 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ACSM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005739 mitochondrion --
GO:0005759 mitochondrial matrix IEA --
genes like me logo Genes that share ontologies with ACSM3: view

Pathways for ACSM3 Gene

genes like me logo Genes that share pathways with ACSM3: view

Pathways by source for ACSM3 Gene

2 KEGG pathways for ACSM3 Gene

Gene Ontology (GO) - Biological Process for ACSM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006633 fatty acid biosynthetic process IEA --
GO:0008152 metabolic process --
GO:0008217 regulation of blood pressure NAS 7907320
GO:0042632 cholesterol homeostasis NAS 15361761
genes like me logo Genes that share ontologies with ACSM3: view

Compounds for ACSM3 Gene

(39) HMDB Compounds for ACSM3 Gene

Compound Synonyms Cas Number PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate Coenzyme A
10018-95-8
(2E)-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-CoA
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate Coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
38795-33-4
genes like me logo Genes that share compounds with ACSM3: view

Transcripts for ACSM3 Gene

Unigene Clusters for ACSM3 Gene

Acyl-CoA synthetase medium-chain family member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ACSM3 Gene

No ASD Table

Relevant External Links for ACSM3 Gene

GeneLoc Exon Structure for
ACSM3
ECgene alternative splicing isoforms for
ACSM3

Expression for ACSM3 Gene

mRNA expression in normal human tissues for ACSM3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ACSM3 Gene

This gene is overexpressed in Ovary (11.0), Liver (6.1), and Kidney - Cortex (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ACSM3 Gene

SOURCE GeneReport for Unigene cluster for ACSM3 Gene Hs.706754

genes like me logo Genes that share expressions with ACSM3: view

No data available for mRNA Expression by UniProt/SwissProt for ACSM3 Gene

Orthologs for ACSM3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ACSM3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ACSM3 35
  • 99.43 (n)
  • 98.98 (a)
ACSM3 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ACSM3 35
  • 89.93 (n)
  • 88.95 (a)
ACSM3 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ACSM3 35
  • 89.87 (n)
  • 87.91 (a)
ACSM3 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Acsm3 35
  • 86.77 (n)
  • 86.66 (a)
Acsm3 16
Acsm3 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ACSM3 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 74 (a)
OneToMany
-- 36
  • 73 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Acsm3 35
  • 86.19 (n)
  • 84.92 (a)
chicken
(Gallus gallus)
Aves ACSM3 35
  • 69.24 (n)
  • 66.31 (a)
ACSM3 36
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ACSM3 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia acsm3 35
  • 68.62 (n)
  • 67.36 (a)
zebrafish
(Danio rerio)
Actinopterygii acsm3 35
  • 64.91 (n)
  • 66.97 (a)
acsm3 36
  • 63 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG8834 36
  • 20 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea acs-16 36
  • 16 (a)
OneToMany
Species with no ortholog for ACSM3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ACSM3 Gene

ENSEMBL:
Gene Tree for ACSM3 (if available)
TreeFam:
Gene Tree for ACSM3 (if available)

Paralogs for ACSM3 Gene

Paralogs for ACSM3 Gene

genes like me logo Genes that share paralogs with ACSM3: view

Variants for ACSM3 Gene

Sequence variations from dbSNP and Humsavar for ACSM3 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs5709 -- 20,763,890(+) AAGAG(G/T)AACCG upstream-variant-2KB
rs5710 -- 20,763,981(+) CAGTC(C/T)TGCTC upstream-variant-2KB
rs5712 -- 20,770,008(+) AATCC(C/T)GAGTG utr-variant-5-prime
rs5713 - 20,775,918(+) GGAAC(C/T)GGGAT missense, reference
rs5714 -- 20,777,530(+) CTGAT(C/T)GTATC synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for ACSM3 Gene

Variant ID Type Subtype PubMed ID
nsv436835 CNV Insertion 17901297
nsv833165 CNV Loss 17160897
esv2582493 CNV Deletion 19546169
esv1965812 CNV Deletion 18987734
esv2793 CNV Deletion 18987735
esv2714064 CNV Deletion 23290073
esv2664545 CNV Deletion 23128226
esv1008054 CNV Deletion 20482838
esv1388215 CNV Deletion 17803354
esv9416 CNV Loss 19470904

Relevant External Links for ACSM3 Gene

HapMap Linkage Disequilibrium report
ACSM3
Human Gene Mutation Database (HGMD)
ACSM3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACSM3 Gene

Disorders for ACSM3 Gene

(1) MalaCards Diseases for ACSM3 Gene

Search for ACSM3 Gene in MalaCards »

Relevant External Links for ACSM3

Genetic Association Database (GAD)
ACSM3
Human Genome Epidemiology (HuGE) Navigator
ACSM3
genes like me logo Genes that share disorders with ACSM3: view

No data available for UniProtKB/Swiss-Prot for ACSM3 Gene

Publications for ACSM3 Gene

  1. Molecular identification and characterization of two medium-chain acyl-CoA synthetases, MACS1 and the Sa gene product. (PMID: 11470804) Fujino T. … Yamamoto T.T. (J. Biol. Chem. 2001) 2 3 23
  2. Association between SAH, an acyl-CoA synthetase gene, and hypertriglyceridemia, obesity, and hypertension. (PMID: 11772874) Iwai N. … Baba S. (Circulation 2002) 3 23 48
  3. Human SA gene polymorphisms are associated with non-high-density lipoprotein cholesterol in postmenopausal women: a pilot study. (PMID: 19108963) Lin M.W. … Ho L.T. (Maturitas 2009) 3 23 48
  4. Evaluation of the SA locus in human hypertension. (PMID: 7843754) Nabika T. … Soubrier F. (Hypertension 1995) 2 3 4
  5. Human SA gene locus as a candidate locus for essential hypertension. (PMID: 7907320) Iwai N. … Kinoshita M. (Hypertension 1994) 2 3 4

Products for ACSM3 Gene

Sources for ACSM3 Gene

Back to Top

Content