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Aliases for ACSM2B Gene

Aliases for ACSM2B Gene

  • Acyl-CoA Synthetase Medium-Chain Family Member 2B 2 3 4
  • Xenobiotic/Medium-Chain Fatty Acid-CoA Ligase HXM-A 3 4
  • Acyl-CoA Synthetase Medium-Chain Family Member 2 2 3
  • Middle-Chain Acyl-CoA Synthetase 2B 3 4
  • Butyryl-Coenzyme A Synthetase 2B 3 4
  • Butyrate--CoA Ligase 2B 3 4
  • EC 4 63
  • ACSM2 3 4
  • HXMA 3 6
  • Acyl-Coenzyme A Synthetase ACSM2B, Mitochondrial 3
  • Xenobiotic/Medium Chain Fatty Acid:CoA Ligase 2
  • Xenobiotic/Medium-Chain Fatty Acid:CoA Ligase 3
  • HYST1046 3
  • EC 6.2.1 63

External Ids for ACSM2B Gene

Previous HGNC Symbols for ACSM2B Gene

  • ACSM2

Previous GeneCards Identifiers for ACSM2B Gene

  • GC16M020457
  • GC16M019084

Summaries for ACSM2B Gene

GeneCards Summary for ACSM2B Gene

ACSM2B (Acyl-CoA Synthetase Medium-Chain Family Member 2B) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include butyrate-CoA ligase activity. An important paralog of this gene is ACSM6.

UniProtKB/Swiss-Prot for ACSM2B Gene

  • Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4-unsaturated acids (in vitro).

Gene Wiki entry for ACSM2B Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACSM2B Gene

Genomics for ACSM2B Gene

Regulatory Elements for ACSM2B Gene

Genomic Location for ACSM2B Gene

20,536,226 bp from pter
20,576,427 bp from pter
40,202 bases
Minus strand

Genomic View for ACSM2B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ACSM2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACSM2B Gene

Proteins for ACSM2B Gene

  • Protein details for ACSM2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Acyl-coenzyme A synthetase ACSM2B, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • Q86YT1

    Protein attributes for ACSM2B Gene

    577 amino acids
    Molecular mass:
    64271 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Monomer.

neXtProt entry for ACSM2B Gene

Proteomics data for ACSM2B Gene at MOPED

Selected DME Specific Peptides for ACSM2B Gene

Post-translational modifications for ACSM2B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains for ACSM2B Gene

Gene Families for ACSM2B Gene

  • ACS :Acyl-CoA synthetase family

Protein Domains for ACSM2B Gene

Suggested Antigen Peptide Sequences for ACSM2B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q68CK6
  • Belongs to the ATP-dependent AMP-binding enzyme family.
genes like me logo Genes that share domains with ACSM2B: view

Function for ACSM2B Gene

Molecular function for ACSM2B Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a carboxylate + CoA = AMP + diphosphate + an acyl-CoA
UniProtKB/Swiss-Prot EnzymeRegulation: Activated by monovalent cations, such as potassium, rubidium or ammonium.
UniProtKB/Swiss-Prot Function: Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4-unsaturated acids (in vitro).

Enzyme Numbers (IUBMB) for ACSM2B Gene

Gene Ontology (GO) - Molecular Function for ACSM2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003824 catalytic activity --
GO:0005524 ATP binding IEA --
GO:0046872 metal ion binding IEA --
GO:0047760 butyrate-CoA ligase activity IEA --
genes like me logo Genes that share ontologies with ACSM2B: view

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ACSM2B Gene

Localization for ACSM2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACSM2B Gene

Mitochondrion matrix.

Subcellular locations from

Jensen Localization Image for ACSM2B Gene COMPARTMENTS Subcellular localization image for ACSM2B gene
Compartment Confidence
mitochondrion 5
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ACSM2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion NAS 19634011
GO:0005759 mitochondrial matrix TAS --
genes like me logo Genes that share ontologies with ACSM2B: view

Pathways for ACSM2B Gene

genes like me logo Genes that share pathways with ACSM2B: view

Pathways by source for ACSM2B Gene

Interacting Proteins for ACSM2B Gene

Gene Ontology (GO) - Biological Process for ACSM2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006631 fatty acid metabolic process IEA --
GO:0006805 xenobiotic metabolic process TAS --
GO:0008152 metabolic process --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with ACSM2B: view

Compounds for ACSM2B Gene

(41) HMDB Compounds for ACSM2B Gene

Compound Synonyms Cas Number PubMed IDs
  • (E)-S-2-decenoate Coenzyme A
  • 2-trans-Dodecenoyl-Coenzyme A
  • trans-2-Hexadecenoyl-CoA
  • (E)-S-2-octenoate Coenzyme A
  • (2E)-Tetradecenoyl-Coenzyme A
genes like me logo Genes that share compounds with ACSM2B: view

Transcripts for ACSM2B Gene

Unigene Clusters for ACSM2B Gene

Acyl-CoA synthetase medium-chain family member 2B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ACSM2B Gene

No ASD Table

Relevant External Links for ACSM2B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ACSM2B Gene

mRNA expression in normal human tissues for ACSM2B Gene

mRNA differential expression in normal tissues according to GTEx for ACSM2B Gene

This gene is overexpressed in Liver (34.4) and Kidney - Cortex (18.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ACSM2B Gene

SOURCE GeneReport for Unigene cluster for ACSM2B Gene Hs.298252

mRNA Expression by UniProt/SwissProt for ACSM2B Gene

Tissue specificity: Detected in liver.
genes like me logo Genes that share expressions with ACSM2B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for ACSM2B Gene

Orthologs for ACSM2B Gene

This gene was present in the common ancestor of animals.

Orthologs for ACSM2B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ACSM2B 35
  • 98.73 (n)
  • 97.75 (a)
  • 98 (a)
(Bos Taurus)
Mammalia ACSM2A 36
  • 80 (a)
(Canis familiaris)
Mammalia -- 36
  • 78 (a)
(Mus musculus)
Mammalia Acsm2 36
  • 73 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 60 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 73 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4563 36
  • 18 (a)
(Caenorhabditis elegans)
Secernentea acs-16 36
  • 17 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 20 (a)
Species with no ortholog for ACSM2B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for ACSM2B Gene

Gene Tree for ACSM2B (if available)
Gene Tree for ACSM2B (if available)

Paralogs for ACSM2B Gene

Paralogs for ACSM2B Gene

genes like me logo Genes that share paralogs with ACSM2B: view

Variants for ACSM2B Gene

Sequence variations from dbSNP and Humsavar for ACSM2B Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs1054968 -- 20,542,973(-) TGATG(A/G)AGCAC reference, missense
rs1064029 -- 20,537,212(-) TCTTT(C/T)TTTTC utr-variant-3-prime
rs1505099 -- 20,557,773(-) agaac(C/T)taaaa intron-variant
rs1505106 -- 20,539,302(+) AATTA(C/G)CCTGT intron-variant
rs1505107 -- 20,539,042(-) TTTAC(A/C/G)GTCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ACSM2B Gene

Variant ID Type Subtype PubMed ID
nsv436835 CNV Insertion 17901297
esv1311 CNV CNV 17122850
nsv7279 OTHER Inversion 18451855
dgv827e1 CNV Complex 17122850
dgv828e1 CNV Complex 17122850
nsv1760 CNV Loss 18451855
esv27489 CNV Loss 19812545
dgv829e1 CNV Complex 17122850
essv5757 CNV CNV 17122850
nsv905572 CNV Gain+Loss 21882294
nsv905573 CNV Loss 21882294
nsv833164 CNV Loss 17160897
nsv442394 CNV CNV 18776908
nsv905574 CNV Loss 21882294
nsv905575 CNV Gain 21882294
nsv521570 CNV Gain 19592680
esv2533542 CNV Loss 19546169
nsv103483 CNV Insertion 16902084
nsv507808 CNV Insertion 20534489

Relevant External Links for ACSM2B Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACSM2B Gene

Disorders for ACSM2B Gene

Relevant External Links for ACSM2B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with ACSM2B: view

No data available for UniProtKB/Swiss-Prot for ACSM2B Gene

Publications for ACSM2B Gene

  1. Comparative analyses of disease risk genes belonging to the acyl-CoA synthetase medium-chain (ACSM) family in human liver and cell lines. (PMID: 19634011) Boomgaarden I. … Doering F. (Biochem. Genet. 2009) 3 4 23
  2. Isolation, sequencing, and expression of a cDNA for the HXM-A form of xenobiotic/medium-chain fatty acid:CoA ligase from human liver mitochondria. (PMID: 12616642) Vessey D.A. … Warren R.S. (J. Biochem. Mol. Toxicol. 2003) 2 3 4
  3. Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas. (PMID: 15221005) Yamada S. … Nakagawara A. (Oncogene 2004) 3 4
  4. The L513S polymorphism in medium-chain acyl-CoA synthetase 2 (MACS2) is associated with risk factors of the metabolic syndrome in a Caucasian study population. (PMID: 16521160) Lindner I. … Doering F. (Mol. Nutr. Food Res. 2006) 3 48
  5. Characterization of the CoA ligases of human liver mitochondria catalyzing the activation of short- and medium-chain fatty acids and xenobiotic carboxylic acids. (PMID: 10434065) Vessey D.A. … Warren R.S. (Biochim. Biophys. Acta 1999) 3 4

Products for ACSM2B Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Drug Metabolism: Phase II Enzymes in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate ACSM2B
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for ACSM2B
    • Block miRNA regulation of ACSM2B using miScript Target Protectors

    Sources for ACSM2B Gene

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