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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ACSM2B Gene

protein-coding   GIFtS: 55
GCID: GC16M020547

acyl-CoA synthetase medium-chain family member 2B

(Previous name: acyl-CoA synthetase medium-chain family member 2 )
(Previous symbol: ACSM2)
 Explore 2 diseases affiliated with
ACSM2B via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ACSM2B    

Aliases
for ACSM2B gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Acyl-CoA Synthetase Medium-Chain Family Member 2B1 2 3     Xenobiotic/Medium-Chain Fatty Acid-CoA Ligase HXM-A2 3
ACSM21 2 3     EC 6.2.1.23 8
HXMA1 2     HYST10461
Acyl-CoA Synthetase Medium-Chain Family Member 21 2     Acyl-Coenzyme A Synthetase ACSM2B, Mitochondrial2
Butyrate--CoA Ligase 2B2 3     Xenobiotic/Medium-Chain Fatty Acid:CoA Ligase2
Butyryl-Coenzyme A Synthetase 2B2 3     EC 6.2.18
Middle-Chain Acyl-CoA Synthetase 2B2 3     

External Ids:    HGNC: 309311   Entrez Gene: 3481582   Ensembl: ENSG000000668137   OMIM: 6143595   UniProtKB: Q68CK63   

Export aliases for ACSM2B gene to outside databases

Previous GC identifers: GC16M020457 GC16M019084


Summaries
for ACSM2B gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: ACS2B_HUMAN, Q68CK6
Function: Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids
from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4-unsaturated acids (in vitro)

Gene Wiki entry for ACSM2B


Genomic Views
for ACSM2B gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.1  NT_010393.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ACSM2B gene promoter:
         AML1a   Pax-2a   NF-kappaB   GATA-2   E47   RORalpha1   NF-kappaB2   c-Myb   SEF-1 (1)   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ACSM2B promoter sequence
   Search SABiosciences Chromatin IP Primers for ACSM2B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ACSM2B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p12.3   Ensembl cytogenetic band:  16p12.3   HGNC cytogenetic band: 16p12.3

ACSM2B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ACSM2B gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M020547:  view genomic region     (about GC identifiers)

Start:
 20,547,548 bp from pter      End:
 20,587,749 bp from pter
Size:
 40,202 bases      Orientation:
 minus strand

Proteins
for ACSM2B gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ACS2B_HUMAN, Q68CK6 (See protein sequence)
Recommended Name: Acyl-coenzyme A synthetase ACSM2B, mitochondrial precursor  
Size: 577 amino acids; 64271 Da
Cofactor: Magnesium or manganese
Subunit: Monomer
Subcellular location: Mitochondrion matrix
Secondary accessions: Q86YT1

Explore the universe of human proteins at neXtProt for ACSM2B: NX_Q68CK6

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q68CK6

    • 4/7 DME Specific Peptides for ACSM2B (Q68CK6) (see all 7)
     APYKYPR  SGYRIGP  GNVLPPG  DILYRLQ 

    ACSM2B Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001098539.1  NP_872423.3  

    ENSEMBL proteins: 
     ENSP00000327453   ENSP00000457377   ENSP00000454995   ENSP00000456378   ENSP00000455137  
     ENSP00000454887   ENSP00000456369   ENSP00000455190   ENSP00000454247   ENSP00000455658  
     ENSP00000390378  
    Reactome Protein details: Q68CK6
    Human Recombinant Protein Products: 
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    OriGene Purified Proteins (see all 2): ACSM2B
    OriGene Protein Over-expression Lysate (see all 2): ACSM2B
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    Uscn Proteins for ACSM2B

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion NAS19634011
    GO:0005759mitochondrial matrix TAS--


    ACSM2B for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for ACSM2B

    Protein Domains /
    Families
    for ACSM2B gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ACSM2B for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR000873 AMP-dep_Synth/Lig
     IPR020845 AMP-binding_CS
     IPR025110 DUF4009

    Graphical View of Domain Structure for InterPro Entry Q68CK6

    ProtoNet protein and cluster: Q68CK6

    1 Blocks protein family: IPB000873 AMP-binding signature

    UniProtKB/Swiss-Prot: ACS2B_HUMAN, Q68CK6
    Similarity: Belongs to the ATP-dependent AMP-binding enzyme family


    Function
    for ACSM2B gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ACS2B_HUMAN, Q68CK6
    Function: Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids
    from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4-unsaturated acids (in vitro)
    Catalytic activity: ATP + a carboxylate + CoA = AMP + diphosphate + an acyl-CoA
    Enzyme regulation: Activated by monovalent cations, such as potassium, rubidium or ammonium

    Enzyme Numbers (IUBMB): EC 6.2.1.21 2 EC 6.2.12

    miRNA
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    Inhib. RNA
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    Gene Editing
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    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for ACSM2B

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACSM2B

    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0003824catalytic activity ----
    GO:0005524ATP binding IEA--
    GO:0046872metal ion binding IEA--
    GO:0047760butyrate-CoA ligase activity IEA--


    ACSM2B for ontologies           About GeneDecksing



    Pathways & Interactions
    for ACSM2B gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Amino Acid conjugation
    		Conjugation of carboxylic acids1.00
    		Conjugation of salicylate with glycine0.67
    		Amino Acid conjugation1.00
    		Conjugation of phenylacetate with glutamine0.67
    		Conjugation of benzoate with glycine1.00
    2Metabolism
    		Metabolism1.00
    		Metabolic pathways0.38
    3Biological oxidations
    		Biological oxidations1.00
    		Phase II conjugation0.52
    4Valproic Acid Pathway, Pharmacokinetics
    		Valproic Acid Pathway, Pharmacokinetics1.00
    5Ketone body metabolism
    		Butanoate metabolism0.17

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5/8        Reactome Pathways for ACSM2B (see all 8)
        Conjugation of carboxylic acids
    Conjugation of phenylacetate with glutamine
    Conjugation of benzoate with glycine
    Metabolism
    Biological oxidations

    1 PharmGKB Pathway for ACSM2B
        Valproic Acid Pathway, Pharmacokinetics

    2         Kegg Pathways  (Kegg details for ACSM2B):
        Butanoate metabolism
    Metabolic pathways


    ACSM2B for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ACSM2B

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for ACSM2B (Q68CK63 ENSP000003274534) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ESR2Q927313, ENSP000003439254I2D: score=1 STRING: ENSP00000343925
    ACADSENSP000002425924STRING: ENSP00000242592
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006631fatty acid metabolic process IEA--
    GO:0006805xenobiotic metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--


    ACSM2B for ontologies           About GeneDecksing



    Drugs & Compounds
    for ACSM2B gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ACSM2B

    10/41 HMDB Compounds for ACSM2B (see all 41)    About this table
    CompoundSynonyms CAS #PubMed Ids
    (2E)-Decenoyl-CoA(E)-S-2-decenoate Coenzyme A (see all 15)10018-95-8--
    (2E)-Dodecenoyl-CoA2-trans-Dodecenoyl-Coenzyme A (see all 4)1066-12-2--
    (2E)-Hexadecenoyl-CoAtrans-2-Hexadecenoyl-CoA (see all 4)4460-95-1--
    (2E)-Octenoyl-CoA(E)-S-2-octenoate Coenzyme A (see all 16)10018-94-7--
    (2E)-Tetradecenoyl-CoA(2E)-Tetradecenoyl-Coenzyme A (see all 8)38795-33-4--
    2-Methylbutyryl-CoA2-methylbutanoyl-CoA (see all 11)6712-02-3--
    2-Methylhexanoyl-CoA2-Methylhexanoyl-CoEnzyme A (see all 5)----
    3Z-dodecenoyl-CoAS-[2-[3-[[(2R)-4-[[[(2R,3R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (Z)-dodec-3-enethioate (see all 4)2152-91-2--
    Acetyl-CoAS-Acetyl coenzyme A (see all 13)72-89-9--
    Acrylyl-CoAAcryloyl coenzyme A (see all 14)5776-58-9--
    Search CenterWatch for drugs/clinical trials and news about ACSM2B / ACS2B 

    Transcripts
    for ACSM2B gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ACSM2B gene (2 alternative transcripts): 
    NM_001105069.1  NM_182617.3  

    Unigene Clusters for ACSM2B:

    Acyl-CoA synthetase medium-chain family member 2B
    Hs.298252  [show with all ESTs], Hs.567879  [show with all ESTs]
    Unigene Representative Sequences: NM_001010845, NM_182617
    18/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000329697(uc002dhj.4 uc002dhk.4) ENST00000566998 ENST00000565322
    ENST00000565232 ENST00000567001 ENST00000568098 ENST00000564849 ENST00000569131
    ENST00000569364(uc010bwf.1) ENST00000563943 ENST00000567288 ENST00000569327
    ENST00000569163 ENST00000568882 ENST00000566384 ENST00000569344 ENST00000562026
    ENST00000564855

    miRNA
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    Inhib. RNA
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    OriGene shRNA RFP: ACSM2B
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AK129944.1 AK309601.1 BC026010.1 

    14 DOTS entries:

    DT.95213309  DT.111109  DT.100794152  DT.92429486  DT.120715984  DT.92068161  DT.86855341  DT.86840851 
    DT.40209231  DT.91671853  DT.100023997  DT.100023998  DT.40274534  DT.91836818 

    24/71 AceView cDNA sequences (see all 71):

    AW051750 CB162130 AI763277 AW300484 AW772619 AV720328 AA886200 AA923512 
    AW511916 BG429560 CB147210 AA865601 CB163791 AA894912 BV205427 AK129944 
    BI765323 AV653859 AI733070 BF115066 NM_182617 AA001337 BG192354 AB073604 

    GeneLoc Exon Structure


    Expression
    for ACSM2B gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ACSM2B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ACSM2B expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Human kidney epithelial cell spheroids (Kidney spheroids for...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ACSM2B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ACSM2B

    SOURCE GeneReport for Unigene clusters: Hs.298252 Hs.567879

    UniProtKB/Swiss-Prot: ACS2B_HUMAN, Q68CK6
    Tissue specificity: Detected in liver

        SABiosciences Expression via Pathway-Focused PCR Array including ACSM2B: 
              Drug Metabolism: Phase II Enzymes in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for ACSM2B gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for ACSM2B gene from 4/14 species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    zebrafish
    (Danio rerio)    		 Actinopterygii acsm36
    		 acyl-CoA synthetase medium-chain family member 3
    		 50(a)
    		 1 → many
    		 2(44787051-44808224)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT3G489906
    		 AMP-dependent synthetase and ligase-like protein
    		 22(a)
    		 possible ortholog
    		 3(18158747-18161379)
    rice
    (Oryza sativa)    		 Liliopsida --
    		 AMP-binding domain containing protein, expressed
    		 21(a)
    		 possible ortholog
    		 4(34723331-34725551)
    E. coli
    (Escherichia coli)    		 Gamma proteobacteria aas6
    		 fused 2-acylglycerophospho-ethanolamine acyl trans...
    		 12(a)
    		 possible ortholog
    		 Chromosome(2971877-2974036)


    ENSEMBL Gene Tree for ACSM2B (if available)
    TreeFam Gene Tree for ACSM2B (if available) 

    Paralogs
    for ACSM2B gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ACSM2B gene
    C10orf1292  ACSM52  ACSM32  ACSS22  ACSM2A2  ACSM12  ACSM42  ACSS32  
    ACSF22  ACSS12  
    10 SIMAP similar genes for ACSM2B using alignment to 8 protein entries:     ACS2B_HUMAN (see all proteins):
    ACSM2A    C10orf129    ACSM4    ACSM3    61E3.4    NPIPL3
    ACSM1    ACSM5    A-923A4.2    ACSM6

    ACSM2B for paralogs           About GeneDecksing



    Genomic Variants
    for ACSM2B gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/932 NCBI SNPs in ACSM2B are shown (see all 932)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 16 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1481368611,2
    		Cother20570625(+) CACACG/AATCCC 4 /R /C mis11Minor allele frequency- A:0.00NA 4532
    rs99329931,2
    		C,A,--19084590(+) TTTTAA/CAATTt 1 -- us2k10--------
    rs620350521,2
    		--19084858(+) TCCCTG/AACTTA 1 -- us2k11Minor allele frequency- A:0.50NA 2
    rs1148219601,2
    		C,F,--19084949(+) AGTAAT/GGTTTT 1 -- us2k11Minor allele frequency- G:0.06WA 118
    rs620350531,2
    		--19085317(+) TAGCCG/TCCCTG 1 -- us2k11Minor allele frequency- T:0.50NA 2
    rs1118262181,2
    		C,F--19085608(+) TGGACC/AAAAGG 1 -- us2k12Minor allele frequency- A:0.50NA 4
    rs1129711131,2
    		C,F--19085634(+) AGTTAC/TTGGTA 1 -- us2k12Minor allele frequency- T:0.50NA 4
    rs1135565881,2
    		C,F--19085638(+) ATTGGC/TATGGA 1 -- us2k12Minor allele frequency- T:0.50NA 4
    rs75000641,2
    		C,H--19085803(+) AATTTC/TACTAT 1 -- us2k16Minor allele frequency- T:0.00NS EA NA 424
    rs1131908861,2
    		--19085824(+) TAAAAG/AGAATG 1 -- us2k13Minor allele frequency- A:0.28CSA WA 121

    HapMap Linkage Disequilibrium report for ACSM2B (20547548 - 20587749 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 5 variations for ACSM2B
         5 CNVs: 3113 102226 38881 66954 35364
    Human Gene Mutation Database (HGMD): ACSM2B

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ACSM2B
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    Disorders / Diseases
    for ACSM2B gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ACSM2B for disorders           About GeneDecksing

    OMIM gene information: 614359    OMIM disorders: --

    2 diseases for ACSM2B:    About MalaCards
    hepatoblastoma    hypertension

    Human Genome Epidemiology (HuGE) Navigator: ACSM2B (2 documents)

    Export disorders for ACSM2B gene to outside databases

    Publications
    for ACSM2B gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ACSM2B gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with ACSM2B)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation, sequencing, and expression of a cDNA for the HXM-A form of xenobiotic/medium-chain fatty acid:CoA ligase from human liver mitochondria. (PubMed id 12616642)1, 2, 3 Vessey D.A.... Warren R.S. (2003)
    2. Comparative analyses of disease risk genes belonging to the acyl-CoA synthetase medium-chain (ACSM) family in human liver and cell lines. (PubMed id 19634011)1, 2, 9 Boomgaarden I.... Doering F. (2009)
    3. Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas. (PubMed id 15221005)1, 2 Yamada S....Nakagawara A. (2004)
    4. Characterization of the CoA ligases of human liver mitochondria catalyzing the activation of short- and medium-chain fatty acids and xenobiotic carboxylic acids. (PubMed id 10434065)1, 2 Vessey D.A.... Warren R.S. (1999)
    5. Characterization of triacsin C inhibition of short-, medium-, and long-chain fatty acid: CoA ligases of human liver. (PubMed id 15122652)1, 9 Vessey D.A....Warren R.S. (2004)
    6. Pharmacogenetic analysis of lipid responses to rosuva statin in Chinese patients. (PubMed id 20679960)1 Hu M....Tomlinson B. (2010)
    7. The L513S polymorphism in medium-chain acyl-CoA synthetase 2 (MACS2) is associated with risk factors of the metabolic syndrome in a Caucasian study population. (PubMed id 16521160)1 Lindner I.... Doering F. (2006)
    8. The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)2 Martin J.... Pennacchio L.A. (2004)
    9. Characterization of the reaction mechanism for the XL-I form of bovine liver xenobiotic/medium-chain fatty acid:CoA ligase. (PubMed id 11415461)1 Vessey D.A. and Kelley M. (2001)
    10. Interaction of salicylate and ibuprofen with the carboxylic acid: CoA ligases from bovine liver mitochondria. (PubMed id 8884467)1 Vessey D.A....Kelley M. (1996)

    External Searches for ACSM2B gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
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    Genome Databases showing ACSM2B gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 348158 HGNC: 30931 AceView: HXMA Ensembl:ENSG00000066813 euGenes: HUgn348158
    ECgene: ACSM2B Kegg: 348158 H-InvDB: ACSM2B

    Other Databases showing ACSM2B gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ACSM2B gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ACSM2B Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ACSM2B gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ACSM2B gene:
    Search GeneIP for patents involving ACSM2B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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