Aliases for ACSM2A Gene
External Ids for ACSM2A Gene
Previous HGNC Symbols for ACSM2A Gene
Previous GeneCards Identifiers for ACSM2A Gene
This gene encodes a mitochondrial acyl-coenzyme A synthetase that is specific for medium chain fatty acids. These enzymes catalyze fatty acid activation, the first step of fatty acid metabolism, through the transfer of acyl-CoA. These enzymes also participate in the glycine conjugation pathway in the detoxification of xenobiotics such as benzoate and ibuprofen. Expression levels of this gene in the kidney may be correlated with kidney function. This gene and its paralog ACSM2B (Gene ID: 348158), both present on chromosome 16, likely arose from a chromosomal duplication event. [provided by RefSeq, May 2017]
GeneCards Summary for ACSM2A Gene
ACSM2A (Acyl-CoA Synthetase Medium-Chain Family Member 2A) is a Protein Coding gene. Among its related pathways are Conjugation of carboxylic acids and Valproic Acid Pathway, Pharmacokinetics. GO annotations related to this gene include butyrate-CoA ligase activity. An important paralog of this gene is ACSM2B.
UniProtKB/Swiss-Prot for ACSM2A Gene
Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4-unsaturated acids (in vitro) (By similarity).