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Aliases for ACSM2A Gene

Aliases for ACSM2A Gene

  • Acyl-CoA Synthetase Medium-Chain Family Member 2A 2 3 4
  • Acyl-CoA Synthetase Medium-Chain Family Member 2 2 3
  • Middle-Chain Acyl-CoA Synthetase 2A 3 4
  • Butyryl-Coenzyme A Synthetase 2A 3 4
  • Butyrate--CoA Ligase 2A 3 4
  • EC 6.2.1.2 4 63
  • ACSM2 3 4
  • Acyl-Coenzyme A Synthetase ACSM2A, Mitochondrial 3
  • Homolog Of Rat Kidney-Specific (KS) 3
  • A-923A4.1 3
  • EC 6.2.1 63
  • MACS2 4

External Ids for ACSM2A Gene

Previous Symbols for ACSM2A Gene

  • ACSM2

Summaries for ACSM2A Gene

GeneCards Summary for ACSM2A Gene

ACSM2A (Acyl-CoA Synthetase Medium-Chain Family Member 2A) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include butyrate-CoA ligase activity. An important paralog of this gene is ACSM2B.

UniProtKB/Swiss-Prot for ACSM2A Gene

  • Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4-unsaturated acids (in vitro) (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACSM2A Gene

Genomics for ACSM2A Gene

Genomic Location for ACSM2A Gene

Start:
20,451,461 bp from pter
End:
20,487,669 bp from pter
Size:
36,209 bases
Orientation:
Plus strand

Genomic View for ACSM2A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ACSM2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACSM2A Gene

Regulatory Elements for ACSM2A Gene

Proteins for ACSM2A Gene

  • Protein details for ACSM2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q08AH3-ACS2A_HUMAN
    Recommended name:
    Acyl-coenzyme A synthetase ACSM2A, mitochondrial
    Protein Accession:
    Q08AH3
    Secondary Accessions:
    • B3KTT9
    • O75202

    Protein attributes for ACSM2A Gene

    Size:
    577 amino acids
    Molecular mass:
    64223 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Monomer.
    SequenceCaution:
    • Sequence=AAC23497.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ACSM2A Gene

neXtProt entry for ACSM2A Gene

Proteomics data for ACSM2A Gene at MOPED

Selected DME Specific Peptides for ACSM2A Gene

Post-translational modifications for ACSM2A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ACSM2A Gene

Domains for ACSM2A Gene

Gene Families for ACSM2A Gene

HGNC:
  • ACS :Acyl-CoA synthetase family

Protein Domains for ACSM2A Gene

Suggested Antigen Peptide Sequences for ACSM2A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q08AH3

UniProtKB/Swiss-Prot:

ACS2A_HUMAN
Family:
  • Belongs to the ATP-dependent AMP-binding enzyme family.:
    • Q08AH3
genes like me logo Genes that share domains with ACSM2A: view

Function for ACSM2A Gene

Molecular function for ACSM2A Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a carboxylate + CoA = AMP + diphosphate + an acyl-CoA
UniProtKB/Swiss-Prot Function: Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4-unsaturated acids (in vitro) (By similarity).

Enzyme Numbers (IUBMB) for ACSM2A Gene

Gene Ontology (GO) - Molecular Function for ACSM2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0005524 ATP binding IEA --
GO:0046872 metal ion binding IEA --
GO:0047760 butyrate-CoA ligase activity IDA 19345228
genes like me logo Genes that share ontologies with ACSM2A: view

miRNA for ACSM2A Gene

miRTarBase miRNAs that target ACSM2A

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ACSM2A Gene

Localization for ACSM2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACSM2A Gene

Mitochondrion matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ACSM2A Gene COMPARTMENTS Subcellular localization image for ACSM2A gene
Compartment Confidence
mitochondrion 4
nucleus 2
cytosol 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ACSM2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion NAS 19634011
GO:0005759 mitochondrial matrix IEA --
genes like me logo Genes that share ontologies with ACSM2A: view

Pathways for ACSM2A Gene

genes like me logo Genes that share pathways with ACSM2A: view

Pathways by source for ACSM2A Gene

Interacting Proteins for ACSM2A Gene

Gene Ontology (GO) - Biological Process for ACSM2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006631 fatty acid metabolic process IEA --
GO:0008152 metabolic process --
GO:0036112 medium-chain fatty-acyl-CoA metabolic process IDA 19345228
GO:0042593 glucose homeostasis NAS 16521160
GO:0070328 triglyceride homeostasis NAS 16521160
genes like me logo Genes that share ontologies with ACSM2A: view

Compounds for ACSM2A Gene

(40) HMDB Compounds for ACSM2A Gene

Compound Synonyms Cas Number PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate Coenzyme A
10018-95-8
(2E)-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-CoA
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate Coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
38795-33-4
genes like me logo Genes that share compounds with ACSM2A: view

Transcripts for ACSM2A Gene

Unigene Clusters for ACSM2A Gene

Acyl-CoA synthetase medium-chain family member 2A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ACSM2A Gene

No ASD Table

Relevant External Links for ACSM2A Gene

GeneLoc Exon Structure for
ACSM2A
ECgene alternative splicing isoforms for
ACSM2A

Expression for ACSM2A Gene

mRNA expression in normal human tissues for ACSM2A Gene

mRNA differential expression in normal tissues according to GTEx for ACSM2A Gene

This gene is overexpressed in Liver (34.0) and Kidney - Cortex (18.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ACSM2A Gene

SOURCE GeneReport for Unigene cluster for ACSM2A Gene Hs.656497

genes like me logo Genes that share expressions with ACSM2A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ACSM2A Gene

Orthologs for ACSM2A Gene

This gene was present in the common ancestor of animals.

Orthologs for ACSM2A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ACSM2A 35
  • 99.13 (n)
  • 98.79 (a)
ACSM2A 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ACSM2A 36
  • 80 (a)
OneToMany
ACSM2B 35
  • 83.82 (n)
  • 81.07 (a)
dog
(Canis familiaris)
Mammalia -- 36
  • 79 (a)
OneToMany
ACSM2A 35
  • 82.38 (n)
  • 79.03 (a)
mouse
(Mus musculus)
Mammalia Acsm2 35
  • 81.01 (n)
  • 76.31 (a)
Acsm2 16
Acsm2 36
  • 73 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 61 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 73 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Acsm2a 35
  • 81.88 (n)
  • 77.97 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11453 36
  • 19 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea acs-16 36
  • 17 (a)
OneToMany
Species with no ortholog for ACSM2A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for ACSM2A Gene

ENSEMBL:
Gene Tree for ACSM2A (if available)
TreeFam:
Gene Tree for ACSM2A (if available)

Paralogs for ACSM2A Gene

Paralogs for ACSM2A Gene

Selected SIMAP similar genes for ACSM2A Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with ACSM2A: view

Variants for ACSM2A Gene

Sequence variations from dbSNP and Humsavar for ACSM2A Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs1018893 -- 20,478,332(+) CTAGA(A/G)CCAAA intron-variant
rs1054977 - 20,486,625(+) AACGA(A/G)CCAAG missense, reference, nc-transcript-variant
rs1054982 -- 20,486,682(+) GAGAC(A/G)TCTAA utr-variant-3-prime, nc-transcript-variant
rs1054985 -- 20,486,687(+) ATCTA(A/G)GAGAC utr-variant-3-prime, nc-transcript-variant
rs1055007 -- 20,486,824(+) AAAAC(A/T)TTACC utr-variant-3-prime, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for ACSM2A Gene

Variant ID Type Subtype PubMed ID
nsv436835 CNV Insertion 17901297
nsv905570 CNV Gain 21882294
dgv826e1 CNV Complex 17122850
esv1311 CNV CNV 17122850
nsv905571 CNV Gain 21882294
nsv437805 CNV Loss 16327808
esv2675909 CNV Deletion 23128226
nsv7279 OTHER Inversion 18451855
nsv525413 CNV Loss 19592680
dgv346n27 CNV Loss 19166990
dgv827e1 CNV Complex 17122850
nsv516604 CNV Loss 19592680
dgv48n17 CNV Loss 16327808
dgv828e1 CNV Complex 17122850
nsv1760 CNV Loss 18451855
nsv9389 CNV Loss 18304495
esv26098 CNV Loss 19812545
nsv827582 CNV Gain 20364138

Relevant External Links for ACSM2A Gene

HapMap Linkage Disequilibrium report
ACSM2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACSM2A Gene

Disorders for ACSM2A Gene

Relevant External Links for ACSM2A

Genetic Association Database (GAD)
ACSM2A
Human Genome Epidemiology (HuGE) Navigator
ACSM2A
genes like me logo Genes that share disorders with ACSM2A: view

No data available for UniProtKB/Swiss-Prot for ACSM2A Gene

Publications for ACSM2A Gene

  1. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PMID: 10493829) Loftus B.J. … Adams M.D. (Genomics 1999) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48
  4. The L513S polymorphism in medium-chain acyl-CoA synthetase 2 (MACS2) is associated with risk factors of the metabolic syndrome in a Caucasian study population. (PMID: 16521160) Lindner I. … Doering F. (Mol. Nutr. Food Res. 2006) 3 4
  5. Structural snapshots for the conformation-dependent catalysis by human medium-chain acyl-coenzyme A synthetase ACSM2A. (PMID: 19345228) Kochan G. … Yue W.W. (J. Mol. Biol. 2009) 3 4

Products for ACSM2A Gene

Sources for ACSM2A Gene

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