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Aliases for ACSL6 Gene

Aliases for ACSL6 Gene

  • Acyl-CoA Synthetase Long-Chain Family Member 6 2 3
  • FACL6 3 4 6
  • ACS2 3 4 6
  • Fatty-Acid-Coenzyme A Ligase, Long-Chain 6 2 3
  • EC 6.2.1.3 4 64
  • LACS 6 3 4
  • LACS5 3 4
  • Long-Chain-Fatty-Acid--CoA Ligase 6 3
  • Long Fatty Acyl-CoA Synthetase 2 3
  • Long-Chain Acyl-CoA Synthetase 6 4
  • KIAA0837 4
  • EC 6.2.1 64
  • LACS2 3

External Ids for ACSL6 Gene

Previous Symbols for ACSL6 Gene

  • FACL6

Summaries for ACSL6 Gene

Entrez Gene Summary for ACSL6 Gene

  • The protein encoded by this gene catalyzes the formation of acyl-CoA from fatty acids, ATP, and CoA, using magnesium as a cofactor. The encoded protein plays a major role in fatty acid metabolism in the brain. Translocations with the ETV6 gene are causes of myelodysplastic syndrome with basophilia, acute myelogenous leukemia with eosinophilia, and acute eosinophilic leukemia. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2011]

GeneCards Summary for ACSL6 Gene

ACSL6 (Acyl-CoA Synthetase Long-Chain Family Member 6) is a Protein Coding gene. Diseases associated with ACSL6 include myelodysplastic syndrome. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include protein homodimerization activity and long-chain fatty acid-CoA ligase activity. An important paralog of this gene is ACSBG2.

UniProtKB/Swiss-Prot for ACSL6 Gene

  • Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilized exclusively for the synthesis of the brain lipid

Gene Wiki entry for ACSL6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACSL6 Gene

Genomics for ACSL6 Gene

Genomic Location for ACSL6 Gene

Start:
131,806,990 bp from pter
End:
132,012,243 bp from pter
Size:
205,254 bases
Orientation:
Minus strand

Genomic View for ACSL6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ACSL6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACSL6 Gene

Regulatory Elements for ACSL6 Gene

Proteins for ACSL6 Gene

  • Protein details for ACSL6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKU0-ACSL6_HUMAN
    Recommended name:
    Long-chain-fatty-acid--CoA ligase 6
    Protein Accession:
    Q9UKU0
    Secondary Accessions:
    • J3KPG3
    • O94924
    • O95829
    • Q108M9
    • Q108N0
    • Q4G191
    • Q86TN7

    Protein attributes for ACSL6 Gene

    Size:
    697 amino acids
    Molecular mass:
    77752 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH26161.1; Type=Erroneous termination; Positions=72; Note=Translated as Arg.; Evidence={ECO:0000305}; Sequence=BAA74860.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for ACSL6 Gene

neXtProt entry for ACSL6 Gene

Proteomics data for ACSL6 Gene at MOPED

Post-translational modifications for ACSL6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains for ACSL6 Gene

Gene Families for ACSL6 Gene

HGNC:
  • ACS :Acyl-CoA synthetase family

Protein Domains for ACSL6 Gene

UniProtKB/Swiss-Prot:

ACSL6_HUMAN
Family:
  • Belongs to the ATP-dependent AMP-binding enzyme family.:
    • Q9UKU0
genes like me logo Genes that share domains with ACSL6: view

Function for ACSL6 Gene

Molecular function for ACSL6 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA
UniProtKB/Swiss-Prot Function: Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilized exclusively for the synthesis of the brain lipid

Enzyme Numbers (IUBMB) for ACSL6 Gene

Gene Ontology (GO) - Molecular Function for ACSL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004467 long-chain fatty acid-CoA ligase activity NAS 10548543
GO:0005515 protein binding --
GO:0005524 ATP binding IEA --
GO:0019899 enzyme binding IPI 20429931
genes like me logo Genes that share ontologies with ACSL6: view

miRNA for ACSL6 Gene

miRTarBase miRNAs that target ACSL6

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ACSL6 Gene

Localization for ACSL6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACSL6 Gene

Mitochondrion outer membrane; Single-pass type III membrane protein. Peroxisome membrane; Single-pass type III membrane protein. Microsome membrane; Single-pass type III membrane protein. Endoplasmic reticulum membrane; Single-pass type III membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ACSL6 Gene COMPARTMENTS Subcellular localization image for ACSL6 gene
Compartment Confidence
endoplasmic reticulum 5
mitochondrion 5
peroxisome 5
plasma membrane 5
nucleus 2
cytosol 1

Gene Ontology (GO) - Cellular Components for ACSL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005739 mitochondrion --
GO:0005741 mitochondrial outer membrane IEA --
GO:0005777 peroxisome --
GO:0005778 peroxisomal membrane IEA --
genes like me logo Genes that share ontologies with ACSL6: view

Pathways for ACSL6 Gene

genes like me logo Genes that share pathways with ACSL6: view

Gene Ontology (GO) - Biological Process for ACSL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IEA --
GO:0001676 long-chain fatty acid metabolic process IEA --
GO:0006637 acyl-CoA metabolic process NAS 10548543
GO:0006641 triglyceride metabolic process --
GO:0007405 neuroblast proliferation IEA --
genes like me logo Genes that share ontologies with ACSL6: view

Compounds for ACSL6 Gene

(41) HMDB Compounds for ACSL6 Gene

Compound Synonyms Cas Number PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate Coenzyme A
10018-95-8
(2E)-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-CoA
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate Coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
38795-33-4

(1) Novoseek inferred chemical compound relationships for ACSL6 Gene

Compound -log(P) Hits PubMed IDs
acyl-coa 71.5 4
genes like me logo Genes that share compounds with ACSL6: view

Transcripts for ACSL6 Gene

Unigene Clusters for ACSL6 Gene

Acyl-CoA synthetase long-chain family member 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ACSL6 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b
SP1: - -
SP2: - -
SP3: - - - - -
SP4:

Relevant External Links for ACSL6 Gene

GeneLoc Exon Structure for
ACSL6
ECgene alternative splicing isoforms for
ACSL6

Expression for ACSL6 Gene

mRNA expression in normal human tissues for ACSL6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ACSL6 Gene

This gene is overexpressed in Brain - Cerebellum (5.5), Brain - Cerebellar Hemisphere (5.4), Brain - Frontal Cortex (BA9) (5.1), Brain - Anterior cingulate cortex (BA24) (4.7), and Brain - Cortex (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ACSL6 Gene

SOURCE GeneReport for Unigene cluster for ACSL6 Gene Hs.14945

mRNA Expression by UniProt/SwissProt for ACSL6 Gene

Q9UKU0-ACSL6_HUMAN
Tissue specificity: Expressed predominantly in erythrocyte precursors, in particular in reticulocytes, fetal blood cells derived from fetal liver, hemopoietic stem cells from cord blood, bone marrow and brain.
genes like me logo Genes that share expressions with ACSL6: view

Orthologs for ACSL6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ACSL6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ACSL6 36
  • 97.84 (n)
  • 98.38 (a)
ACSL6 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ACSL6 36
  • 91.15 (n)
  • 94.26 (a)
ACSL6 37
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ACSL6 36
  • 91.51 (n)
  • 95.43 (a)
ACSL6 37
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Acsl6 36
  • 88.86 (n)
  • 91.82 (a)
Acsl6 16
Acsl6 37
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ACSL6 37
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ACSL6 37
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Acsl6 36
  • 87.42 (n)
  • 90.53 (a)
chicken
(Gallus gallus)
Aves ACSL6 36
  • 77.38 (n)
  • 84.7 (a)
ACSL6 37
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ACSL6 37
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia acsl6 36
  • 71.28 (n)
  • 78.53 (a)
zebrafish
(Danio rerio)
Actinopterygii acsl1a 36
  • 65.85 (n)
  • 65.32 (a)
acsl6 37
  • 82 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG3961 37
  • 48 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea acs-13 37
  • 45 (a)
ManyToMany
acs-15 37
  • 33 (a)
ManyToMany
acs-5 37
  • 45 (a)
ManyToMany
R09E10.4 37
  • 27 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FAA2 37
  • 29 (a)
OneToMany
barley
(Hordeum vulgare)
Liliopsida Hv.10667 36
wheat
(Triticum aestivum)
Liliopsida Ta.27153 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 50 (a)
ManyToMany
CSA.10659 37
  • 50 (a)
ManyToMany
Species with no ortholog for ACSL6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for ACSL6 Gene

ENSEMBL:
Gene Tree for ACSL6 (if available)
TreeFam:
Gene Tree for ACSL6 (if available)

Paralogs for ACSL6 Gene

Paralogs for ACSL6 Gene

genes like me logo Genes that share paralogs with ACSL6: view

Variants for ACSL6 Gene

Sequence variations from dbSNP and Humsavar for ACSL6 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs30159 -- 131,970,842(+) TTTTA(C/T)TTTGG intron-variant
rs30160 -- 131,970,569(+) CACAC(C/G)TGGCT intron-variant
rs30161 -- 131,969,968(+) CAATG(C/T)CACAA intron-variant
rs30162 -- 131,967,921(+) ATGAA(C/T)GGCTA intron-variant
rs40819 -- 131,969,691(-) TGGCC(A/C)CTATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ACSL6 Gene

Variant ID Type Subtype PubMed ID
esv25745 CNV Gain 19812545
esv272200 CNV Insertion 20981092

Relevant External Links for ACSL6 Gene

HapMap Linkage Disequilibrium report
ACSL6

Disorders for ACSL6 Gene

UniProtKB/Swiss-Prot

ACSL6_HUMAN
  • Note=A chromosomal aberration involving ACSL6 may be a cause of myelodysplastic syndrome with basophilia. Translocation t(5;12)(q31;p13) with ETV6.
  • Note=A chromosomal aberration involving ACSL6 may be a cause of acute myelogenous leukemia with eosinophilia. Translocation t(5;12)(q31;p13) with ETV6.
  • Note=A chromosomal aberration involving ACSL6 may be a cause of acute eosinophilic leukemia (AEL). Translocation t(5;12)(q31;p13) with ETV6.

(1) MalaCards Diseases for ACSL6 Gene

Search for ACSL6 Gene in MalaCards »

Relevant External Links for ACSL6

Genetic Association Database (GAD)
ACSL6
Human Genome Epidemiology (HuGE) Navigator
ACSL6
genes like me logo Genes that share disorders with ACSL6: view

Publications for ACSL6 Gene

  1. Fusion of TEL/ETV6 to a novel ACS2 in myelodysplastic syndrome and acute myelogenous leukemia with t(5;12)(q31;p13). (PMID: 10502316) Yagasaki F. … Hirashima K. (Genes Chromosomes Cancer 1999) 2 3 4 23
  2. Identification and molecular characterization of acyl-CoA synthetase in human red cells and erythroid precursor. (PMID: 10548543) Malhotra K.T. … Kuypers F.A. (Biochem. J. 1999) 2 3 4 23
  3. Multiple erythroid isoforms of human long-chain acyl-CoA synthetases are produced by switch of the fatty acid gate domains. (PMID: 16834775) Soupene E. … Kuypers F.A. (BMC Mol. Biol. 2006) 3 4 23
  4. Acyl-CoA synthetase long-chain family member 6 is associated with premature ovarian failure. (PMID: 18555221) Kang H. … Kwack K. (Fertil. Steril. 2009) 3 23 49
  5. Association of haplotypes spanning PDZ-GEF2, LOC728637 and ACSL6 with schizophrenia in Han Chinese. (PMID: 18718982) Luo X.J. … Su B. (J. Med. Genet. 2008) 3 49

Products for ACSL6 Gene

Sources for ACSL6 Gene

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