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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ACSL6 Gene

protein-coding GIFtS: 61
GCID: GC05M131147

acyl-CoA synthetase long-chain family member 6

(Previous names: fatty-acid-Coenzyme A ligase, long-chain 6 )
(Previous symbol: FACL6)

Explore 13 diseases affiliated with
ACSL6 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Acyl-CoA Synthetase Long-Chain Family Member 6¹ ²		LACS 6² ³
ACS2¹ ² ³ ⁵		EC 6.2.1.3³ ⁸
FACL6¹ ² ³ ⁵		Long Fatty Acyl-CoA Synthetase 2²
LACS5¹ ² ³		Long-Chain-Fatty-Acid--CoA Ligase 6²
LACS2¹ ²		Long-Chain Acyl-CoA Synthetase 6³
Fatty-Acid-Coenzyme A Ligase, Long-Chain 6¹ ²		EC 6.2.1⁸
KIAA0837¹ ³

External Ids:	HGNC: 16496¹	Entrez Gene: 23305²	Ensembl: ENSG00000164398⁷	OMIM: 604443⁵	UniProtKB: Q9UKU0³

Export aliases for ACSL6 gene to outside databases

Previous GC identifers: GC05M131366 GC05M131170 GC05M126481 GC05M131144 GC05M131145 GC05M131146

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ACSL6:

The protein encoded by this gene catalyzes the formation of acyl-CoA from fatty acids, ATP, and CoA, using magnesium as

a cofactor. The encoded protein plays a major role in fatty acid metabolism in the brain. Translocations with the ETV6

gene are causes of myelodysplastic syndrome with basophilia, acute myelogenous leukemia with eosinophilia, and acute

eosinophilic leukemia. Several transcript variants encoding different isoforms have been found for this gene.(provided

by RefSeq, Apr 2011)

UniProtKB/Swiss-Prot: ACSL6_HUMAN, Q9UKU0

Function: Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via

beta-oxidation. Plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilized

exclusively for the synthesis of the brain lipid

Gene Wiki entry for ACSL6

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000005.9 NC_018916.1 NT_034772.6

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ACSL6 gene promoter:
NRSF form 1 AP-2gamma NRSF form 2 FAC1 FOXO1a AP-2alpha FOXO1 AP-2alphaA
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ACSL6 promoter sequence

Search SABiosciences Chromatin IP Primers for ACSL6

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ACSL6

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31 Ensembl cytogenetic band: 5q31.1 HGNC cytogenetic band: 5q31

ACSL6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ACSL6 gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05M131147: view genomic region (about GC identifiers)

Start:	131,142,683 bp from pter	End:	131,347,936 bp from pter
Size:	205,254 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ACSL6_HUMAN, Q9UKU0 (See protein sequence)

Recommended Name: Long-chain-fatty-acid--CoA ligase 6

Size: 697 amino acids; 77752 Da

Cofactor: Magnesium

Subcellular location: Mitochondrion outer membrane; Single-pass type III membrane protein (By similarity). Peroxisome

membrane; Single-pass type III membrane protein (By similarity). Microsome membrane; Single-pass type III membrane

protein (By similarity). Endoplasmic reticulum membrane; Single-pass type III membrane protein (By similarity)

Developmental stage: Expression is low at earlier stages of erythroid development but is very high in reticulocytes

Sequence caution: Sequence=BAA74860.1; Type=Erroneous initiation;

Secondary accessions: O94924 O95829 Q108M9 Q108N0 Q86TN7

Alternative splicing: 8 isoforms: Q9UKU0-4 Q9UKU0-1 Q9UKU0-2 Q9UKU0-3 Q9UKU0-5 Q9UKU0-6 Q9UKU0-7 Q9UKU0-8

(No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ACSL6: NX_Q9UKU0

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9UKU0

4/13 DME Specific Peptides for ACSL6 (Q9UKU0) (see all 13)

YGQTECT

KGAMLTH

LPLAHMFE

VPLYDTLG

ACSL6 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (6 alternative transcripts):

NP_001009185.1 NP_001192176.1 NP_001192177.1 NP_001192179.1 NP_001192180.1 NP_056071.2

ENSEMBL proteins:

ENSP00000415140 ENSP00000368566 ENSP00000368557 ENSP00000296869 ENSP00000368548

ENSP00000368546 ENSP00000368542 ENSP00000413329 ENSP00000397507 ENSP00000398423

ENSP00000388424 ENSP00000398381 ENSP00000394810 ENSP00000389189 ENSP00000368551

ENSP00000368574 ENSP00000349608 ENSP00000442124 ENSP00000445154

Reactome Protein details: Q9UKU0
Human Recombinant Protein Products:

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	GenScript Custom Purified and Recombinant Proteins Services for ACSL6
	Novus Biologicals ACSL6 Protein
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for ACSL6

Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005739	mitochondrion	--	--
GO:0005741	mitochondrial outer membrane	IEA	--
GO:0005778	peroxisomal membrane	IEA	--
GO:0005789	endoplasmic reticulum membrane	TAS	--

ACSL6 for ontologies About GeneDecksing

ACSL6 Antibody Products:

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	Novus Biologicals ACSL6 Antibodies
	Search for Antibodies for ACSL6 at Abcam
	Uscn Antibodies for ACSL6
	ThermoFisher Antibodies for ACSL6

Assay Products for ACSL6:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for ACSL6
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for ACSL6

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ACSL6 for domains About GeneDecksing

2 InterPro domains/families:

IPR000873 AMP-dep_Synth/Lig

IPR020845 AMP-binding_CS

Graphical View of Domain Structure for InterPro Entry Q9UKU0

ProtoNet protein and cluster: Q9UKU0

1 Blocks protein family: IPB000873 AMP-binding signature

UniProtKB/Swiss-Prot: ACSL6_HUMAN, Q9UKU0

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ACSL6_HUMAN, Q9UKU0

Function: Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via

beta-oxidation. Plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilized

exclusively for the synthesis of the brain lipid

Catalytic activity: ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA

Enzyme Numbers (IUBMB): EC 6.2.1.3¹ ² EC 6.2.1²

miRNA Products:		OriGene 3'-UTR Clone (see all 2): ACSL6 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ACSL6
		8/91 QIAGEN miScript miRNA Assays for microRNAs that regulate ACSL6 (see all 91):
		hsa-miR-548j hsa-miR-140-5p hsa-miR-579 hsa-miR-520e hsa-miR-3653 hsa-miR-374a hsa-miR-3613-3p hsa-miR-548a-5p

		SwitchGear 3'UTR luciferase reporter plasmid: ACSL6 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ACSL6 (see all 7) OriGene shRNA RFP: ACSL6 OriGene siRNA: ACSL6
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ACSL6

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for ACSL6

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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		GenScript: all cDNA clones in your preferred vector (see all 6): ACSL6 (NM_015256)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ACSL6
		Search LifeMap BioReagents cell lines for ACSL6

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACSL6

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003824	catalytic activity	--	--
GO:0004467	long-chain fatty acid-CoA ligase activity	NAS	10548543
GO:0005515	protein binding	--	--
GO:0005524	ATP binding	IEA	--
GO:0019899	enzyme binding	IPI	--

ACSL6 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Metabolism

	Metabolism	1.00			Metabolism of lipids and lipoproteins	0.34
	Metabolic pathways	0.38

Fatty Acyl-CoA Biosynthesis

	Fatty Acyl-CoA Biosynthesis	1.00			Triglyceride Biosynthesis	0.47
	Synthesis of very long-chain fatty acyl-CoAs	0.78

fatty acid alpha-oxidation II

fatty acid alpha-oxidation II

1.00

fatty acid beta-oxidation I

0.39

Fatty Acid Beta Oxidation

Fatty Acid Beta Oxidation

1.00

Fatty acid metabolism

0.32

Fatty Acid Biosynthesis

Fatty Acid Biosynthesis

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

4 BioSystems Pathways for ACSL6

	fatty acid alpha-oxidation II
	Fatty Acid Beta Oxidation
	fatty acid beta-oxidation I
	Fatty Acid Biosynthesis

5/6 Reactome Pathways for ACSL6 (see all 6)

	Metabolism
	Synthesis of very long-chain fatty acyl-CoAs
	Triglyceride Biosynthesis
	Fatty Acyl-CoA Biosynthesis
	Fatty acid, triacylglycerol, and ketone body metabolism

5 Kegg Pathways (Kegg details for ACSL6):

	Fatty acid metabolism
	Metabolic pathways
	PPAR signaling pathway
	Peroxisome
	Adipocytokine signaling pathway

ACSL6 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for ACSL6

STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

5/23 Interacting proteins for ACSL6 (Q9UKU0³ ENSP00000296869⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 23)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PHYH	O14832³, ENSP00000263038⁴	I2D: score=2 STRING: ENSP00000263038
YWHAB	P31946³	I2D: score=1
ACADVL	ENSP00000325395⁴	STRING: ENSP00000325395
ACOX1	ENSP00000293217⁴	STRING: ENSP00000293217
CPT1A	ENSP00000265641⁴	STRING: ENSP00000265641

About this table

Gene Ontology (GO): 5/19 biological process terms (GO ID links to tree view) (see all 19): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001666	response to hypoxia	IEA	--
GO:0001676	long-chain fatty acid metabolic process	IDA	--
GO:0006631	fatty acid metabolic process	--	--
GO:0006637	acyl-CoA metabolic process	NAS	10548543
GO:0007405	neuroblast proliferation	IEA	--

ACSL6 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

ACSL6 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ACSL6

10/41 HMDB Compounds for ACSL6 (see all 41) About this table

Compound	Synonyms	CAS #	PubMed Ids
(2E)-Decenoyl-CoA	(E)-S-2-decenoate Coenzyme A (see all 15)	10018-95-8	--
(2E)-Dodecenoyl-CoA	2-trans-Dodecenoyl-Coenzyme A (see all 4)	1066-12-2	--
(2E)-Hexadecenoyl-CoA	trans-2-Hexadecenoyl-CoA (see all 4)	4460-95-1	--
(2E)-Octenoyl-CoA	(E)-S-2-octenoate Coenzyme A (see all 16)	10018-94-7	--
(2E)-Tetradecenoyl-CoA	(2E)-Tetradecenoyl-Coenzyme A (see all 8)	38795-33-4	--
2-Methylbutyryl-CoA	2-methylbutanoyl-CoA (see all 11)	6712-02-3	--
2-Methylhexanoyl-CoA	2-Methylhexanoyl-CoEnzyme A (see all 5)	--	--
20-COOH-leukotriene E4	20-COOH-LTE4 (see all 3)	--	--
3Z-dodecenoyl-CoA	S-[2-[3-[[(2R)-4-[[[(2R,3R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (Z)-dodec-3-enethioate (see all 4)	2152-91-2	--
6,9,12,15,18,21-Tetracosahexaenoic acid	all-cis-6,9,12,15,18,21-tetracosahexaenoate (see all 8)	--	--

1 Novoseek chemical compound relationship for ACSL6 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
acyl-coa	71.5	5	10548543 (2), 16834775 (1), 18555221 (1)

Search CenterWatch for drugs/clinical trials and news about ACSL6

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ACSL6 gene (6 alternative transcripts):

NM_001009185.2 NM_001205247.1 NM_001205248.1 NM_001205250.1 NM_001205251.1 NM_015256.3

Unigene Cluster for ACSL6:

Acyl-CoA synthetase long-chain family member 6

Hs.14945 [show with all ESTs]

Unigene Representative Sequence: NM_001009185

18/25 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 25):

ENST00000413683(uc003kvv.1) ENST00000379264(uc003kvw.2 uc010jdn.2 uc003kwb.3 uc003kvx.2 uc003kvy.2 uc003kvz.2 uc010jdo.2 uc021ydh.1 uc003kwa.2)

ENST00000379255 ENST00000296869 ENST00000493861 ENST00000379246 ENST00000379244

ENST00000379240 ENST00000431707(uc010jdp.1) ENST00000492156 ENST00000484870

ENST00000434099 ENST00000489047 ENST00000430403 ENST00000419502 ENST00000416557

ENST00000414078(uc003kwd.1) ENST00000441995(uc003kwc.1)

miRNA Products:		OriGene 3'-UTR Clone (see all 2): ACSL6 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ACSL6
		8/91 QIAGEN miScript miRNA Assays for microRNAs that regulate ACSL6 (see all 91):
		hsa-miR-548j hsa-miR-140-5p hsa-miR-579 hsa-miR-520e hsa-miR-3653 hsa-miR-374a hsa-miR-3613-3p hsa-miR-548a-5p

		SwitchGear 3'UTR luciferase reporter plasmid: ACSL6 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ACSL6 (see all 7) OriGene shRNA RFP: ACSL6 OriGene siRNA: ACSL6
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ACSL6

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ACSL6 (see all 7) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ACSL6 (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 6): ACSL6 (NM_015256)
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ACSL6
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ACSL6

Additional cDNA sequence:

AB020644.1 AF102845.1 AF129166.1 AK122702.1 AK294291.1 AK314452.1 AL390168.1 BC026161.1

BC047453.1 DQ083030.1 DQ083031.1 DQ655980.2 DQ655981.2

14 DOTS entries:

DT.114429 DT.97802307 DT.101979938 DT.95335733 DT.91729677 DT.100740408 DT.100745250 DT.95303299

DT.120830163 DT.95157759 DT.97781490 DT.100683394 DT.100717679 DT.91933626

24/146 AceView cDNA sequences (see all 146):

R11709 AA701011 AI658711 BM709686 BM704515 AI924268 W91993 AA243861

AA843570 AA059164 F10555 BE326767 N49244 BU734183 AL041092 AK122702

BM992189 CR606980 AA426087 BQ184700 AA707814 AL707192 BF438057 CR600821

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for ACSL6 About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12a	·	12b	·	12c	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^	20	^	21a	·	21b
SP1:																							-		-
SP2:																					-				-
SP3:			-																		-		-		-		-
SP4:

ECgene alternative splicing isoforms for ACSL6

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ACSL6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

ACSL6 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Blood Brain Barrier

Postnatal Endothelial Cells

Blood Brain Barrier, Endothelium

Neural Tube

Telencephalon

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ACSL6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ACSL6

SOURCE GeneReport for Unigene cluster: Hs.14945

UniProtKB/Swiss-Prot: ACSL6_HUMAN, Q9UKU0

Tissue specificity: Expressed predominantly in erythrocyte precursors, in particular in reticulocytes, fetal blood

cells derived from fetal liver, hemopoietic stem cells from cord blood, bone marrow and brain

SABiosciences Expression via Pathway-Focused PCR Array including ACSL6:

Fatty Acid Metabolism in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ACSL6 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ACSL6

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ACSL6

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for ACSL6 gene from 8/29 species (see all 29) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Acsl6^{1 , 5}	acyl-CoA synthetase long-chain family member 6^{1, 5}	88.41(n)¹ 91.55(a)¹		11 (32.13 cM)⁵ 216739¹ NM_001033597.1¹ NP_001028769.1¹ 54303798⁵
chicken (Gallus gallus)	Aves	ACSL6¹	acyl-CoA synthetase long-chain family member 6	77.81(n) 85.73(a)		416324 XM_414641.3 XP_414641.3
lizard (Anolis carolinensis)	Reptilia	ACSL6⁶	--	85(a)	1 ↔ 1	2(128431076-128476847)
zebrafish (Danio rerio)	Actinopterygii	acsl6¹	acyl-CoA synthetase long-chain family member 6	70.59(n) 75.52(a)		566863 XM_001920904.4 XP_001920939.3
fruit fly (Drosophila melanogaster)	Insecta	CG3961⁶	--	47(a)	1 → many	3L(18871350-18883583)
worm (Caenorhabditis elegans)	Secernentea	acs-13⁶ acs-5⁶ (see all 6)	fatty Acid CoA Synthetase family member (acs-14) (see all 6)	45(a) 43(a) (see all 6)	many ↔ many many ↔ many (see all 6)	I(511051-516459) III(13540037-13543433)
thale cress (Arabidopsis thaliana)	eudicotyledons	LACS7⁶ LACS6⁶ (see all 7)	long-chain acyl-CoA synthetase 6 (see all 7)	40(a) 39(a) (see all 7)	possible ortholog possible ortholog (see all 7)	5(9742576-9747005) 3(1786318-1791802)
rice (Oryza sativa)	Liliopsida	AK065216.1²	--	73.59(n)		AK065216.1

ENSEMBL Gene Tree for ACSL6 (if available)
TreeFam Gene Tree for ACSL6 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for ACSL6 gene

ACSBG1² ACSL3² ACSL4² ACSBG2² ACSL1² ACSL5²

6 SIMAP similar genes for ACSL6 using alignment to 12 protein entries: ACSL6_HUMAN (see all proteins):

ACSL5 FACL5 ACSL1 ACSL3 ACSL4 FACL4

ACSL6 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs58886402^1,2	C,	--	126478103(+)	`AAGTAT/CACTGA`	6	--	ds500¹		2		WA	120
rs11749245^1,2	C,H	--	126478822(+)	`TATACG/AGTTAT`	6	--	ut3¹ ese³		4		NS EA	418
rs17132127^1,2	C,F,H,	--	126479488(+)	`ATAGAT/ACCAAT`	6	--	ut3¹		23		NA NS EA WA CSA	2459
rs76060563^1,2		--	126480902(+)	`AATCTA/GTAGCT`	6	--	ut3¹		0	--	--	--	--
rs17132129^1,2	C,F,H,	--	126480914(+)	`GGAACT/CTAATT`	6	--	ut3¹ ese³		11		NA NS EA WA	1350
rs79565098^1,2	C,F,	--	126480999(+)	`TGCAAG/TAAAGG`	6	--	ut3¹		1		WA	118
rs73264073^1,2	C,	--	126481098(+)	`AAAGTT/CTTCTT`	6	--	ut3¹		2		WA	120
rs78190514^1,2		--	126481263(+)	`GCATGC/GGCACA`	6	--	ut3¹		0	--	--	--	--
rs73264074^1,2	C,	--	126483733(+)	`CAAGGG/TAGACG`	6	--	int¹		2		WA	120
rs80057975^1,2	F,	--	126484128(+)	`AAACTA/GAAAAA`	6	--	int¹		1		WA	118

HapMap Linkage Disequilibrium report for ACSL6 (131142683 - 131347936 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ACSL6
1 CNV: 69200

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ACSL6

DNA2.0 Custom Variant and Variant Library Synthesis for ACSL6

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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ACSL6 for disorders About GeneDecksing

OMIM gene information: 604443 OMIM disorders: --

UniProtKB/Swiss-Prot: ACSL6_HUMAN, Q9UKU0

Note=A chromosomal aberration involving ACSL6 may be a cause of myelodysplastic syndrome with basophilia.

Translocation t(5;12)(q31;p13) with ETV6

Note=A chromosomal aberration involving ACSL6 may be a cause of acute myelogenous leukemia with eosinophilia.

Translocation t(5;12)(q31;p13) with ETV6

Note=A chromosomal aberration involving ACSL6 may be a cause of acute eosinophilic leukemia (AEL).

Translocation t(5;12)(q31;p13) with ETV6

13 diseases for ACSL6: About MalaCards

myelodysplastic syndrome eosinophilia leukemia polycythemia vera

premature ovarian failure gestational choriocarcinoma polycythemia placental cancer

choriocarcinoma schizophrenia malaria prostatitis

neuronitis

Human Genome Epidemiology (HuGE) Navigator: ACSL6 (7 documents)

Export disorders for ACSL6 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for ACSL6 gene, integrated from 9 sources (see all 26):
(articles sorted by number of sources associating them with ACSL6)

Utopia: connect your pdf to the dynamic
world of online information

Fusion of TEL/ETV6 to a novel ACS2 in myelodysplastic syndrome and acute myelogenous leukemia with t(5;12)(q31;p13). (PubMed id 10502316)^{1, 2, 3, 9} Yagasaki F.... Hirashima K. (1999)
Identification and molecular characterization of acyl-CoA synthetase in human red cells and erythroid precursor. (PubMed id 10548543)^{1, 2, 3, 9} Malhotra K.T.... Kuypers F.A. (1999)
Multiple erythroid isoforms of human long-chain acyl-CoA synthetases are produced by switch of the fatty acid gate domains. (PubMed id 16834775)^{1, 2, 9} Soupene E. and Kuypers F.A. (2006)
Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)^{1, 2} Nagase T....Ohara O. (1998)
Acyl-CoA synthetase long-chain family member 6 is associated with premature ovarian failure. (PubMed id 18555221)^{1, 9} Kang H....Kwack K. (2009)
A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci. (PubMed id 22412388)¹ Kenny E.E....Peter I. (2012)
ACSL6 is associated with the number of cigarettes smok ed and its expression is altered by chronic nicotine exposure. (PubMed id 22205969)¹ Chen J....Chen X. (2011)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
Activity of the acyl-CoA synthetase ACSL6 isoforms: r ole of the fatty acid Gate-domains. (PubMed id 20429931)¹ Soupene E....Kuypers F.A. (2010)
Association of haplotypes spanning PDZ-GEF2, LOC728637 and ACSL6 with schizophrenia in Han Chinese. (PubMed id 18718982)¹ Luo X.J....Su B. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 23305	HGNC: 16496	AceView: ACSL6	Ensembl:ENSG00000164398	euGenes: HUgn23305
ECgene: ACSL6	Kegg: 23305	H-InvDB: ACSL6

(According to HUGE)
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HUGE: KIAA0837

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for ACSL6	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for ACSL6	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for ACSL6 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for ACSL6 gene:
Search GeneIP for patents involving ACSL6

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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ACSL6 Gene

acyl-CoA synthetase long-chain family member 6

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ACSL6 Gene

acyl-CoA synthetase long-chain family member 6

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